LOCUS       NZ_CP070499            22985 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Natronosporangium hydrolyticum strain DSM 106523 chromosome,
            complete genome.
ACCESSION   NZ_CP070499
VERSION     NZ_CP070499.1
KEYWORDS    RefSeq.
SOURCE      Natronosporangium hydrolyticum
  ORGANISM  Natronosporangium hydrolyticum
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Natronosporangium.
REFERENCE   1  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Natrosporangium hydrolyticum gen. nov., sp. nov, a haloalkaliphilic
            actinobacterium from a soda solonchak soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) Bioinformatics, Leibniz Institute DSMZ,
            Inhoffenstr. 7B, Braunschweig 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-MAY-2020
            Assembly Method                   :: HGAP v. 4
            Assembly Name                     :: 999_Micromonospora_sp_DSM106523
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 580.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016925615.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 06:45:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,188
            CDSs (total)                      :: 5,131
            Genes (coding)                    :: 5,046
            CDSs (with protein)               :: 5,046
            Genes (RNA)                       :: 57
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 85
            CDSs (without protein)            :: 85
            Pseudo Genes (ambiguous residues) :: 0 of 85
            Pseudo Genes (frameshifted)       :: 18 of 85
            Pseudo Genes (incomplete)         :: 72 of 85
            Pseudo Genes (internal stop)      :: 4 of 85
            Pseudo Genes (multiple problems)  :: 8 of 85
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:11:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3907046
            Orig. end                         :: 3930031
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070499.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22985
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="18"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22985
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22985
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12985](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12985
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(556..570)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     CDS             complement(782..934)
                     /gene="allorf_3907828_3907980"
                     /locus_tag="allorf_3907828_3907980"
                     /protein_id="allorf_3907828_3907980"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRRALLTRLGGLSGARLARYDPLQRPSGSPLNPPRAGGRAVALPR
                     LLRLC"
     CDS_motif       complement(890..934)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRRALLTRLGGLSGA"
                     /locus_tag="allorf_3907828_3907980_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(782..889)
                     /prepeptide="core"
                     /locus_tag="allorf_3907828_3907980_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.20"
                     /molecular_weight="3802.5"
                     /monoisotopic_mass="3800.2"
                     /core_sequence="RLARYDPLQRPSGSPLNPPRAGGRAVALPRLLRLC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRRALLTRLGGLSGA"
                     /leader_location="[889:934](-)"
                     /alternative_weights="3820.5"
     gene            complement(945..3443)
                     /gene="ptsP"
                     /locus_tag="JQS43_RS17495"
                     /old_locus_tag="JQS43_17430"
     CDS             complement(945..3443)
                     /EC_number="2.7.3.9"
                     /GO_function="GO:0008965 - phosphoenolpyruvate-protein
                     phosphotransferase activity [Evidence IEA]"
                     /GO_process="GO:0006808 - regulation of nitrogen
                     utilization [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /gene="ptsP"
                     /inference="COORDINATES: protein motif:HMM:TIGR01417.1"
                     /locus_tag="JQS43_RS17495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17430"
                     /product="phosphoenolpyruvate--protein phosphotransferase"
                     /protein_id="WP_239675472.1"
                     /transl_table=11
                     /translation="MVGIVVVAHSYPLAQAAVGLAREMAPGDEVAIAVAAGLDETTLGT
                     DATQIQAAIESVAGPAGVLVLMDLGSAVLSAELALELLDPEVREQVLLCPAPLVEGLVV
                     AVVAAAGGAALAEVAAEATGALAGKQEHLAGPAPAAGEQRAEEPAVVETFTVTNPHGLH
                     ARPAARLVAELRDVAAQVTLRNLTTGAGPVPANSLSRVSTLGALPDHEVEVAASGPEAP
                     TAVERVLALAARGFDDPAPPAPPAGATEPVAEPAAAGPSAAEPAAAEPLTAGSGGPLPA
                     SPGIGIGPIWTPEPPPLTLPDRPAGDPASEADRLREAVGQVRRETQEVRDRTARELGEQ
                     DAAIFDAHVALLDDAELLDQVREQIEAGAPVERAWAEVLGGLAEQFAALPDPYQRARAA
                     DVQAVTEQVLRALLGVASGFVSHDGVLVAADLTPGEVSQLDADLVAGIVLAHGSPTAHS
                     AILARSRRIPMLVAVGAGVLDLPVRTVVALDGQRGELVVDPDPATRERFAGRAREWAER
                     EATARAAAGAPANTRDGVTIEVAANLGTVTDAAEAAAAGADAAGLVRTEFLFVNRAEPP
                     SVSEQERAYRELAEGLGHRPLTLRTLDVGGDKPVPFLPTGQEANPFLGLRGIRLSLARP
                     EILRDQLVAACRVAHDSPVRLMFPMVATRDEVTAALALLDEAITVVGAGRPAGLEVGIM
                     VEVPAAALRVAAFAPLVDFVSIGTNDLTQYTLAAERGNPSVAALADPLDPAVLRLIDEV
                     CRAAPSSVRVAVCGELAADEVAVPVLVGLGVRELSVVPAAVPMVKQAVRQVDLAAAVPL
                     AARAVTLPSAAEVRTLLAGD"
     gene            complement(3474..4109)
                     /gene="dhaL"
                     /locus_tag="JQS43_RS17500"
                     /old_locus_tag="JQS43_17435"
     CDS             complement(3474..4109)
                     /EC_number="2.7.1.121"
                     /GO_function="GO:0047324 - phosphoenolpyruvate-glycerone
                     phosphotransferase activity [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dhaL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015622556.1"
                     /locus_tag="JQS43_RS17500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17435"
                     /product="dihydroxyacetone kinase subunit DhaL"
                     /protein_id="WP_239675473.1"
                     /transl_table=11
                     /translation="MSSDITVSDLTGWLTEFGRLIKAHKEELTALDAAIGDADHGTNMD
                     RGMTAVAEALAADPPQTPAGLGKQVGMTLVSKVGGASGPLFGTFFLRLGAALGEATEVT
                     PDQFAAGLSAGLAGVVARGKAEPGDKTMVDALTPAVAALESAVGQDQPLADGLAAAAQA
                     AADGRDATVPMLARKGRASYLGERSIGHQDPGATTVALLLAAAATAMS"
     misc_feature    4134..4149
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.42"
                     /tool="antismash"
     CDS             complement(4162..4242)
                     /gene="allorf_3911208_3911288"
                     /locus_tag="allorf_3911208_3911288"
                     /protein_id="allorf_3911208_3911288"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGGPLLYRSFVSLPYARIDQTVTCHQ"
     CDS_motif       complement(4195..4242)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGGPLLYRSFVSLPYA"
                     /locus_tag="allorf_3911208_3911288_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(4162..4194)
                     /prepeptide="core"
                     /locus_tag="allorf_3911208_3911288_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.20"
                     /molecular_weight="1164.3"
                     /monoisotopic_mass="1163.6"
                     /core_sequence="RIDQTVTCHQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGGPLLYRSFVSLPYA"
                     /leader_location="[4194:4242](-)"
                     /alternative_weights="1182.3"
     CDS             complement(4274..4453)
                     /gene="allorf_3911320_3911499"
                     /locus_tag="allorf_3911320_3911499"
                     /protein_id="allorf_3911320_3911499"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MERRSVEDPGVRLEDREWPGRVAAGTHITVSGYRVRARLTSAGDT
                     GHVLDDYCWVGMTD"
     CDS_motif       complement(4391..4453)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MERRSVEDPGVRLEDREWPGR"
                     /locus_tag="allorf_3911320_3911499_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(4274..4390)
                     /prepeptide="core"
                     /locus_tag="allorf_3911320_3911499_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="3926.3"
                     /monoisotopic_mass="3923.9"
                     /core_sequence="VAAGTHITVSGYRVRARLTSAGDTGHVLDDYCWVGMTD"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MERRSVEDPGVRLEDREWPGR"
                     /leader_location="[4390:4453](-)"
                     /alternative_weights="3944.3"
                     /alternative_weights="3962.4"
                     /alternative_weights="3980.4"
                     /alternative_weights="3998.4"
                     /alternative_weights="4016.4"
                     /alternative_weights="4034.4"
     gene            4609..5355
                     /locus_tag="JQS43_RS17505"
                     /old_locus_tag="JQS43_17440"
     CDS             4609..5355
                     /EC_number="2.1.1.-"
                     /NRPS_PKS="Domain: oMT (29-131). E-value: 2.4e-19. Score:
                     60.6. Matches aSDomain: nrpspksdomains_JQS43_RS17505_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="JQS43_RS17505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17440"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_239675474.1"
                     /transl_table=11
                     /translation="MRPTPDEAADTVNRLVLERLQGHLPPDGGRLLDLGCGVGATMVRL
                     AQATQAQVTGVTISRVQAEVGEKRLATAGVADRCEIICLDFAELPTEPRYHAMVGIESI
                     VHSPSVADLVMTLASRLHPGGRLILCDDWATDKDRGVAARERCLAQFRAGWRIGSLHTV
                     AEFAGLAERAGLRLREDLDLTSYLRLGRPRDRLVNVALGAVRALPRVRDRVVDIPFWAN
                     MIGGSALQQGLSRRWLEYRLLLLERV"
     aSDomain        4696..5001
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQS43_RS17505_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.40E-19"
                     /label="JQS43_RS17505_oMT.1"
                     /locus_tag="JQS43_RS17505"
                     /protein_end="131"
                     /protein_start="29"
                     /score="60.6"
                     /tool="antismash"
                     /translation="RLLDLGCGVGATMVRLAQATQAQVTGVTISRVQAEVGEKRLATAG
                     VADRCEIICLDFAELPTEPRYHAMVGIESIVHSPSVADLVMTLASRLHPGGRLILCD"
     gene            5385..7058
                     /locus_tag="JQS43_RS17510"
                     /old_locus_tag="JQS43_17445"
     CDS             5385..7058
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042625.2"
                     /locus_tag="JQS43_RS17510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17445"
                     /product="DUF6541 family protein"
                     /protein_id="WP_239675475.1"
                     /transl_table=11
                     /translation="MSWPRPARLVAWTLLLAAAVGQVRVWSSDRGFWLDELSVAINLRE
                     RAWSELPGGLEYYQVAPVGWLAVTKALREWVGEAEVVLRLPSLVAGVALLVLTMVIARR
                     AVGEWASAVAVGLVGFSPTLLYYSGELKQYAVETAVALGLLLLGDELLRRDPQRRQGAE
                     QENGWRWPVLAAGAGLVAVAVTLSYSALIVLAGVTAGLAAIFAARRQWPAMAVLFLAAA
                     PAAALGVGLAWYRRLYPLAPNQDTWFAHGMPVPGAGVGDVVAWLPQTWTGFVASPLGWR
                     SGWWTLGLVAIGLVALLRRGRGHWAAMAAGVLAMAMVAAVLRGYPLADRVALYLVTPVI
                     LLVVAGVDGVARGVRWVARQIQLVPATAAGTAAAVVAAVAVVMPGPPVGDGVQQMLAPP
                     DRDRGREVLADLAGRVRPGDVVIANWFAEQLGRWYGLEVAGLVRMAPAEDPQLCRPDSV
                     DALLAGASRAWYLHGAPPGSEPADHTVRVAAQLAQRGRIVDAWTLGEDGLSNEPGWILL
                     DLTAGPDPTPPTVEPHPDFACLTETEGVANEHQLTRGGRS"
     gene            7145..8350
                     /locus_tag="JQS43_RS17515"
                     /old_locus_tag="JQS43_17450"
     CDS             7145..8350
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018727566.1"
                     /locus_tag="JQS43_RS17515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17450"
                     /product="amino acid deaminase/aldolase"
                     /protein_id="WP_239675476.1"
                     /transl_table=11
                     /translation="MSRSTDQALRRRLDRATAALDPPFAVVDLAAFDANADALTSAAAG
                     TPIRVASKSVRCRALLRRVLSRPGWRGVLAYTLAEALWLSRTGVSDDVLVGYPSADHGS
                     LVDLVGDPAALATVTLMIDDQAQLDLIDALAPPATRAAPVRLCLDLDASWRPLRRLHVG
                     VRRSPLHTPAQAGALAAAIAARPGYVLTGVMAYEAQIAGVPDAGASPRAAAVRLMQRRS
                     DRELRARRGAVVAEVRRHAQLRFVNGGGTGSLARTVADPAVTEVTAGSGLYGPALFDGY
                     RAWRPTPAALFALPVVRRPSPRIATVAGGGWIGSGATGRSRQPLPWLPAGLRLLGTEGA
                     GEVQTPVTGAAAAGLAPGDRVWFRHAKAGELCEHVTALHLIDGDEIVETVETYRGEGAA
                     FG"
     gene            8347..9660
                     /locus_tag="JQS43_RS17520"
                     /old_locus_tag="JQS43_17455"
     CDS             8347..9660
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0003885 - D-arabinono-1,4-lactone oxidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788788.1"
                     /locus_tag="JQS43_RS17520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17455"
                     /product="D-arabinono-1,4-lactone oxidase"
                     /protein_id="WP_239675477.1"
                     /transl_table=11
                     /translation="MSLPPLTRRRWRNWAGNQRTAGELARPRTVAELAALLRYAGAAGR
                     QVTVVGSGHSFTSIARGADIQIALSGMAGAITRGPTPRTVRVPAGTTLRQLNRWLAAHQ
                     LALPNLGDIDAQTVGGAIATGTHGTGARFGGLASQVVELTLVGADGEVRRCSATEQPDL
                     FAAATVGLGALGVVTEVTLRCVAAFVLHADERPVPLAQTLAEFDEYCADNEHVEFYWLP
                     YTEATLVKRNNRAATDSRPMTRLRAWWENDVLQNVALGGVCKAGRAVPAAAPALARLMA
                     RAFTPVSYTNRSDRIFTTPRRVRFVELEYALPRAALPAAFAELRRIVARSPQRVLLPVE
                     VRVGAGDDSWLSPAYQRNCAYLAIHQYVGAPYQGYFQAVERACAGLDGRPHWGKLHWRD
                     AESLATAYPRFADFLAVRDRLDPGRVFGNPYLARVLGP"
     gene            9792..9998
                     /locus_tag="JQS43_RS17525"
                     /old_locus_tag="JQS43_17460"
     CDS             9792..9998
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040361.3"
                     /locus_tag="JQS43_RS17525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17460"
                     /product="DUF6229 family protein"
                     /protein_id="WP_239675478.1"
                     /transl_table=11
                     /translation="MSTLAPERTAAETVDAWRRGLDDSWENPAGPRFLGDYTESEITLT
                     GGQTNDPATMGSLCTGGICTACC"
     gene            10001..12985
                     /locus_tag="JQS43_RS17530"
                     /old_locus_tag="JQS43_17465"
     CDS             10001..12985
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="JQS43_RS17530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17465"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_239675479.1"
                     /sec_met_domain="DUF4135 (E-value: 9.4e-74, bitscore:
                     247.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 7.8e-29, bitscore:
                     98.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDAVEVALRGDVDRMLSRLVEPPLATLAAQLRSLGTLSEPEQQ
                     VLIAGVRDGLTQVAWRRVSRVVLLELNAARVTGQLTADDADGRWREWVARLAEPDGWER
                     VAAPYPPLLPQLWTLIGNRCAAALRMADRFGRDRGRLGQLVGGALGELQAISTDAGDSH
                     RGGESVTILRCTGGSVVYKPRSVRVDAALDRFLRQVLPDEPEPSRIRVPAVLPSPEDRY
                     GWAEYVPHVYCADQEQLGTFYRNLGHWLAVMRALAGSDLHNENVVACGPVPVVVDCETL
                     FTPPDTSRPSGFGEALDLAAAQTRQSLLRTGLLPGRQALLGWRGVDPSAAGFLPSEQPT
                     VQVPTIADPGTDRARLTLTTGELPASANLPSPEPDLGGYWQAVVGGFSELTEVLHARDA
                     HGELAPLLAEFADCPVRVVVRDTTAYTELGRMLWHPASLHDPPPARRRAAELLVQHAEN
                     RPGAPDAAAVVEAEIDELLDGDVPVFTTTPGTGVLTGPRGTTFGEPRDLVAETLHRWRQ
                     MRPEAERRVIRAAMVGAYLNDGWRPGQDRLPSVTPRADGLDRRRREQAATIVARIATEA
                     IWGRDGSVTWVAPVRSSAGWAVQPLPTDLYGGGFGVAVVLAGYLREVSQSRADPVPGLT
                     ELLAAVVHTIRLAEDQQRRQQADAAALDIRIRPDPPGGYLGIGSRIWGWLLLHQLGVVP
                     GDEARRRASGLAELLPAAAAADREHDLVTGSAGAIVPLLALADQVDAAPADAGAGTDSD
                     SGPRLRALAGQLGDRLQASASRAGAGAGWPTDAYPDGIGGLSHGATGIGWALRRLADAT
                     GRAEFAELAEAAFTREASYFDPDEGAWRDAREGKRHGAAWCHGSVGIGIAADDLLGRRG
                     SGRWEGVLRHAAAHAWADGFGWTHTLCHGDLGAWELLARASARGLGPPGVTAELVAARL
                     LTTLEEHGPMSGMARDAFAPGLLAGEGGVAYQLLRLHPECDLPSVLLPVPASPGRPTGR
                     PTGRS"
     gene            complement(13049..13384)
                     /locus_tag="JQS43_RS17535"
     CDS             complement(13049..13384)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS17535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_239675480.1"
                     /transl_table=11
                     /translation="MAMRRSWRVIAGAGTAAAIVGLGATAALADGIPLQDRSEPGQVEN
                     VNLTGVDDSANSVDSPDSPDSPDSPDSPDSPNSPDSPFDSPDSPDSPDSPDSPDSPDSP
                     DSPDSVD"
     gene            complement(13485..14717)
                     /locus_tag="JQS43_RS17540"
                     /old_locus_tag="JQS43_17475"
     CDS             complement(13485..14717)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.4"
                     /locus_tag="JQS43_RS17540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17475"
                     /product="phosphotransferase"
                     /protein_id="WP_239675481.1"
                     /sec_met_domain="APH (E-value: 2.6e-11, bitscore: 42.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVTAAPQAPGQPWRELLTGPDAGDILQTALVGVGGHLLSWRAHQ
                     VEHRRNGSTAAYRVQVRWPTGEETEERFGAWAGAGPPPPDTLVIGDGTDRVAVWRFPHD
                     PYLPGLATAYDPAAVAGLLRSFDLARAGDEPPRLRVRAYRPHRRAVIEAIGATGHRLFL
                     KVVPPAQAATLHRQHTRFTDAGVPVPPSLGHSADGVVALAALPGHSLRQELRAEAAELP
                     TGAAILALLDRLPAGLADAPVRRSWRDRAGHYATAVASVLPREAERVRELAAAIYAEGG
                     TGPIVPVHGDFYENQVWVAGGRITGLLDLDTAGAGDRLDDLACLLGHLSVLTQLNPAQA
                     ATVSRAGARYLAAFEQRVDPADLRYRVAAVVLSLATGPYRVQESGWQRSTRYRVELAER
                     WLTSARAVRRG"
     gene            complement(14803..15480)
                     /locus_tag="JQS43_RS17545"
                     /old_locus_tag="JQS43_17480"
     CDS             complement(14803..15480)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015622633.1"
                     /locus_tag="JQS43_RS17545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17480"
                     /product="response regulator transcription factor"
                     /protein_id="WP_239675482.1"
                     /transl_table=11
                     /translation="MRWGRDVNRVLIAEDEPRIAAFLEKGLRAAGYVTTVVTSGVDAAG
                     YARSDDFDLMILDLGLPGQDGLAVLTQVRARGERLPVIVLTARDGVRDRVAGLDQGADD
                     YLTKPFSFEELLARVRARLRDQGQAATTTLAVGPIQLDLVRRTVSVDGTEVELTAREFL
                     LAETLARHPGQVLSREQLLDRVWGLGHDPGSNVVDVYIGYLRRKLGADVIQTVRGMGYR
                     FAA"
     gene            complement(15464..16924)
                     /locus_tag="JQS43_RS17550"
                     /old_locus_tag="JQS43_17485"
     CDS             complement(15464..16924)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="JQS43_RS17550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17485"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_239675483.1"
                     /transl_table=11
                     /translation="MTTTDRHQRWRPVVSLRLRLLGWALLLLAVASLGSVVVVRQVLLN
                     QLENRTTADLQQEVSEFRLLAGGRDPTTGEPFGTDLGRIADTYLERNEPQEGEAVFIFV
                     NGAFYGASPDPPFDLTTDPALTNSWTSLRSSQYGEIEQSPAGGARWLAVPVTIEDELQG
                     HVVVVQFTAERRAEIDRAVQLMAFACLLVIVVVAAGGYLAMGRALRPLRTVTEAAREIE
                     ESDLSRRIEVSGSDEVAHLGRTFNGMLGRLERAFAAQQDFLSDVGHELRTPITIVRGHL
                     EVMGDDPQERRETVALVTDELDRMNRMVDDLLMLARAERPDFLQLAQVDVAAVLSEVYT
                     KATALGDRDWQLGRVDAVVTLADRHRLTQALMQLVQNAVQFTEAGDRITLAAEAYYGEL
                     ALSVSDTGIGISPADREMIFERFGRADSSGIRGGRGADGVGLGLAIVTAIATAHRGSVT
                     VASELGVGSTFTLLLPLTRPPGPDEMGA"
     misc_feature    complement(15506..15508)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16911..17228)
                     /locus_tag="JQS43_RS17555"
                     /old_locus_tag="JQS43_17490"
     CDS             complement(16911..17228)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS17555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_17490"
                     /product="hypothetical protein"
                     /protein_id="WP_239675484.1"
                     /transl_table=11
                     /translation="MSAQKVATAVALAALAALFLSVGIPTLVPPAPVGEISLSTGEDDE
                     STGTPDPVPRGRPEPGTVGTPGDPDDSPDSPDSSDSEGDHDSPDTSADVSPDDDGVDDD
                     D"
     misc_feature    17277..17288
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.47"
                     /tool="antismash"
     gene            complement(17491..17886)
                     /locus_tag="JQS43_RS17560"
                     /old_locus_tag="JQS43_17495"
     CDS             complement(17491..17886)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS17560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_17495"
                     /product="hypothetical protein"
                     /protein_id="WP_239675485.1"
                     /transl_table=11
                     /translation="MLERGDLTALHEPFSNLADYGETDLDGRTFESPASLLTWLAGQPP
                     EVGLFLPFIPQALSWEPGERPEWRRSARWHTDVNASSGFQHRDRRYPHTTENSDQLARF
                     AARHRPFYEQLHSQRLIVAPREPMTGP"
     gene            complement(17958..19415)
                     /locus_tag="JQS43_RS17565"
     CDS             complement(17958..19415)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016840.4"
                     /locus_tag="JQS43_RS17565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DinB family protein"
                     /protein_id="WP_239675486.1"
                     /transl_table=11
                     /translation="MTAARLGRVLDPATRAWWRLVGRRVSLAGDHRWLAAPVCGPGPVG
                     ASWLAAEAARTGGAVREDVPTGGLLSSMSVLDGATFRANDLDPGVRDFYEQTACWRMEV
                     WAQWSTLFQPGGELVGRCFGRRVQQLALPTRPLDVAHGMDSRVVHVVDANGDQLSAGWL
                     RTLSATGEFVYSGCYSARLLPGSDQPSVHVTFPLQSGNVQVFLRPSVQADGSLVLSSPA
                     GAFGSEGAYVVVQGSRLAYAARVPIHERFHVYRDGHGVLRTDHELRLYRALVLRLHYRL
                     EPAPAMSAPSRVDRPTPMAGPAKISGDQVARGCRPCEAPSMSSLPAVSAEDVIGQSPRA
                     QFEAFLDQHRRALHDCVAGLTEEQARRSLVSSRTLLGLVKHATFVEKVWFDEAITCRPR
                     AENGIPETPEESFILGDDDTIATVQQAYREACEASRILTASLELDDMVHGNRRGPLPLH
                     WVYLHVLRELAQHCGHADILREQLLDP"
     gene            complement(19444..20214)
                     /locus_tag="JQS43_RS17570"
                     /old_locus_tag="JQS43_17505"
     CDS             complement(19444..20214)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="JQS43_RS17570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17505"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_239675487.1"
                     /transl_table=11
                     /translation="MTEAIGTAPDDYDATHTALHDGALMRLLYAEGMGDQYPAEVEPFS
                     SCTWWLLGQLVSTLRLQPDDLLVDLGCGRGGPGLWLARALSLRLIGVDFSPAAVELAKR
                     RVAAFVPPGRAEFRVATFDQTGLPDGSAAGVVSIDALPIAEDRPAALREVHRILAAGGR
                     CALTVRSRPGVVGKDWQAMALAAGLVVEDALPNPYHDQHWQRLYAIWLANADELRSELG
                     DRAADNLLAEARAGQRRRWDGLPPPLLLVLRRPE"
     CDS             20259..20435
                     /gene="allorf_3927305_3927481"
                     /locus_tag="allorf_3927305_3927481"
                     /protein_id="allorf_3927305_3927481"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSLDDQVLPEDVRRDSQAGWPPRPVGEGSPFEPFGWYASCLSTSS
                     VSTSSGCGHMPTT"
     CDS_motif       20259..20315
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSLDDQVLPEDVRRDSQAG"
                     /locus_tag="allorf_3927305_3927481_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       20316..20435
                     /prepeptide="core"
                     /locus_tag="allorf_3927305_3927481_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.40"
                     /molecular_weight="3872.2"
                     /monoisotopic_mass="3869.8"
                     /core_sequence="WPPRPVGEGSPFEPFGWYASCLSTSSVSTSSGCGHMPTT"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSLDDQVLPEDVRRDSQAG"
                     /leader_location="[20258:20315](+)"
                     /alternative_weights="3890.2"
                     /alternative_weights="3908.3"
                     /alternative_weights="3926.3"
                     /alternative_weights="3944.3"
                     /alternative_weights="3962.3"
                     /alternative_weights="3980.3"
                     /alternative_weights="3998.4"
                     /alternative_weights="4016.4"
                     /alternative_weights="4034.4"
                     /alternative_weights="4052.4"
     misc_feature    20731..20744
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.23"
                     /tool="antismash"
     gene            20763..21959
                     /locus_tag="JQS43_RS17575"
                     /old_locus_tag="JQS43_17515"
     CDS             20763..21959
                     /GO_function="GO:0008452 - RNA ligase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457560.1"
                     /locus_tag="JQS43_RS17575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_17515"
                     /product="RNA ligase RtcB family protein"
                     /protein_id="WP_239679474.1"
                     /transl_table=11
                     /translation="MHSRQQQSLPHSTPATDSATVTVFAASTSWIESDAVAQCHQVAGF
                     DGMIHVAAMPDLHPGKGAPIGAAMTSTVLYPSLVGSDIGCGIAVFPIQLKRAVPERLAA
                     RFPDLDRALDPERDADDPAWEVVDSDIPTGHVEGLGTVGRGNHFVELARIDTAFEPDHA
                     DRLGIAAGDLVLIVHSGSRGLGERILRAHTEVHSAGPAPDPAAYLTMHDHAVRWGSLNR
                     RLMAARVAHALGAEPTEPIVDQCHNLVEVRDGVYLHRKGAAPGNGQDVLIAGTRGTPSY
                     LVAGHAGPEANFSVAHGAGRKMSRADALRRGRAKHTVAELRRTPVGSLVVCGDRQLLFE
                     EAPGAYKRIEQVIADLVSHDLATPVATTVPLVTYKTADVASKPRGDRRDHRRSRGGRR"
     misc_feature    complement(22032..22046)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.02"
                     /tool="antismash"
     gene            22205..22462
                     /locus_tag="JQS43_RS26180"
                     /old_locus_tag="JQS43_17520"
     CDS             22205..22462
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS26180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_17520"
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_338037125.1"
                     /transl_table=11
                     /translation="MIERRQYTEHGDREIALGGEILRTVVGSGVHGIAIAGTDDHDEMG
                     VFVEPPEAVIGVRPPVDHYVYRTQPEGARSGPGDVDLVMY"
ORIGIN
        1 aaggtacggt cgccacctgc gactacgtca aggcgaagcg caagtcgtca aagagcatcc
       61 agatctcctt tgatgaatgg aacgtctggt atatgcatga ctcgccgcac ccaacaccgg
      121 agccgtggac ggaggcgccg cggctgctgg aggatgtcta ctcggtcacc gacgcggtgg
      181 tcttcggcag cctgctgatt gcgatgctgc gccactgcga ccgggtcacc gccgcctgcc
      241 tggcgcagct ggtgaacgtg atcgcgccga tcatgaccga gccgggcggg ccggcgtggc
      301 ggcagaccac cttctacccg ttcgcgcagg cggcccggta tggacgcggc caggtgctgc
      361 ggctggcgat cgacagcccg acgtatgaca ccgccaagca cggtacggtg ccggtgctgc
      421 acgccaccgc ggtcaccggc gaggacgggg tgaccacgct gttcgcggtc aaccgggaca
      481 ccgaccggcc gctgaagctg gtggtggacc tgcgggagct ggcgccccct gacggcccgg
      541 cgcaccactc ggcgctggcc gacccggacc ggcacgcccg caacaccagc gcagagccgg
      601 accgggtgac cccccggcag ctctccggcg cagtgatcga gggcggcaca ctccgcgcca
      661 ccctcccccc gctctcctgg aacaccatcc gcctgagcgc ctgaactcgc tgagtgcccg
      721 ggagggcttg ctccctcccg ggcaggtcaa ccgaggtccg ctacgtggcc tacgagaact
      781 gctagcacaa acggagcagt ctcggtagcg ccacggcgcg cccgccggcc cttggtgggt
      841 tgagtggtga tccactagga cgctgtaacg ggtcatacct ggcaagtcgg gcgccactca
      901 gcccaccaag ccgggtaagg agggctctcc gcaccgagcc ccgtctagtc tccggcgagc
      961 agtgtccgga cctcggcagc gctgggcagg gttaccgccc gggcggcgag cgggacggcc
     1021 gcggccaggt cgacctgccg taccgcctgc ttcaccatcg gcaccgcggc cgggaccacg
     1081 ctcaactctc gcacccccag cccgaccagc accggcaccg cgacctcgtc ggcggcgagt
     1141 tcgccgcaga ccgccacccg gaccgacgac ggggccgctc ggcacacctc gtcgatgagc
     1201 cgcaacaccg ccgggtccaa cggatcggcg agcgcggcca ccgaagggtt gccccgttcg
     1261 gccgcgagcg tgtactgggt caggtcattg gtaccgatgc tgacgaagtc gaccagcggc
     1321 gcgaaggccg ccacccgcag cgccgcggcc ggcacctcca ccatgatccc gacctcgagc
     1381 ccggccggcc gaccggcacc gactacggtg atcgcctcgt cgaggagcgc cagtgcggcg
     1441 gtcacctcat cccgggtggc gaccatcggg aacatcagcc gcaccggcga gtcgtgcgcc
     1501 acccgacagg ccgcgaccag ctggtcgcgc agaatctccg gccgggccag cgagagccgg
     1561 ataccccgta gcccgaggaa cgggttggcc tcttgcccgg tgggcaggaa gggcaccggt
     1621 ttgtccccgc ccacgtccag ggtgcgcagg gtcagtggac ggtggcccaa gccttcggcg
     1681 agctcccggt atgcccgctc ctgttcggac acgctcggcg gctcggcccg gttgacgaag
     1741 aggaactcgg tgcgcaccag cccagcagcg tcggcacccg ccgcagcggc ctcggccgcg
     1801 tcagtcaccg taccgaggtt ggcggcgacc tcaatggtca caccgtcgcg ggtgttggcc
     1861 ggggccccgg cggcggcccg agccgtggcc tcccgctccg cccactcccg tgcccggccg
     1921 gcgaaccgtt cccgggtggc cgggtccggg tcgaccacca gctccccgcg ctgcccgtcc
     1981 agcgctacca ccgtccggac cggcaggtcg agcacgcccg cgccgaccgc gaccagcatc
     2041 ggaatcctcc ggctgcgggc gaggatggcg ctgtgggcgg tcgggctgcc gtgggcgagc
     2101 acaatcccgg cgaccagatc ggcgtcgagc tggctcacct cgcccggggt gaggtcggcg
     2161 gcgaccaaca ccccgtcgtg cgacacgaac ccgctcgcca ccccgagcag ggcgcgcagc
     2221 acctgctcgg tgaccgcctg cacgtcggcg gcgcgggccc gctggtacgg gtcgggcagg
     2281 gcggcgaact gctccgccaa cccgccgagc acctcggccc acgcccgttc gacgggcgcc
     2341 ccggcctcga tctgctcgcg gacctggtcg agcagctccg cgtcgtcgag cagggccacg
     2401 tgcgcatcga agatcgccgc gtcctgctcc cccagctcgc gggcggtacg gtcgcgtacc
     2461 tcctgggttt cccggcggac ctgcccgacc gcttcccgca gccggtcggc ctcggatgcc
     2521 gggtcgccgg ccggccggtc gggcagcgtc agcggcggcg gctcgggcgt ccagatcgga
     2581 ccgatgccga tccctggcga ggcgggcagc ggcccaccgc tgcccgccgt cagcggttcg
     2641 gcggcagctg gctcggccgc cgacggcccg gccgcagcag gctcggcaac gggttcggtc
     2701 gcccccgctg gtggcgccgg cggggccgga tcgtcgaagc ctcgagcggc cagggccaac
     2761 acccgctcga ccgccgtggg cgcctccgga ccgctcgccg ccacctccac ctcatggtcg
     2821 ggcagcgccc ccagcgtcga gacccggctc aggctgttcg ccggcaccgg cccggcgccg
     2881 gtggtgaggt tgcgcagggt cacctgcgcc gccacgtccc gcagctccgc caccagccga
     2941 gccgccggcc gggcatgcag accatgcggg ttggtcacgg tgaacgtctc gaccaccgcc
     3001 ggctcctcag ccctctgctc cccagctgcc ggcgccggcc cggccagatg ctcctgcttg
     3061 ccagccagcg ccccggtcgc ctccgcggcc acctccgcca gcgccgcccc gcccgcggcc
     3121 gccaccaccg ccaccaccag cccctcgacc agcggcgccg ggcagagcag cacctgctcg
     3181 cgtacctctg ggtcgagcag ctccagggcc agctcggcgc tgagcaccgc gctgcccagg
     3241 tccatcagca ccagcacccc ggctggcccg gcaaccgatt cgatcgcagc ctggatctgc
     3301 gtggcgtcgg tgccgagcgt agtctcgtcc aatccggccg cgaccgcgat cgccacctcg
     3361 tcgcccggtg ccatctcccg ggccaacccc accgccgcct gcgccagcgg atagctgtgg
     3421 gcgaccacca cgatgccgac catgccccac tccccccgtt cgtggctgcc gcgtcagctc
     3481 atggccgtcg ccgcggcggc cagcagcagg gccacggtgg tggcccccgg atcctggtgt
     3541 ccgatgctcc gttcacccag gtagctcgcc cgacccttgc gcgccaacat cggcacggtc
     3601 gcgtcccggc cgtcggcggc ggcctgcgcc gctgccgcca acccgtcagc gagcggctgg
     3661 tcctgcccca ccgccgactc cagcgccgcc accgcgggcg tgagcgcgtc gaccatggtc
     3721 ttgtcgccgg gttcggcctt gccccgggcc accacccctg ccaacccggc ggagaggccc
     3781 gcggcgaact ggtccggcgt cacctcggtc gcctcgccca gcgccgcccc gagccgcagg
     3841 aagaaggtgc cgaagagcgg gccggaggcg ccgccgacct tgctgaccag cgtcatcccc
     3901 acctgcttac ccagccccgc cggggtctgc ggcgggtcgg cggcgagcgc ctccgccacc
     3961 gcggtcatgc cgcggtccat gttcgtgccg tggtcggcgt cgccgatagc ggcgtcgagc
     4021 gcggtcagct cctccttatg cgccttgatc aaccggccga actcggtcag ccagccggtc
     4081 aggtcactca cggtgatgtc gctactcatg gtcacactcc cggtcacggt ggtccgcacg
     4141 actgttcgag atcacgatgt gctactggtg gcaggttacg gtttgatcaa tccttgcgta
     4201 tgggagtgac acgaagctcc gatatagcaa gggtcctccc acagaatcgc ctcaccccgg
     4261 agctttctat ggtctagtct gtcatgccca cccagcagta gtcgtcaaga acatggccgg
     4321 tgtcgccagc gctggtgagc cgagcccgga cccggtagcc ggacaccgtg atgtgagtgc
     4381 cggccgctac cctcccaggc cattcacgat cctcgagcct tacaccagga tcttcaaccg
     4441 accgtcgctc catgatgtag catgcgtcaa tgaattctcc ctccccggag gacgcaaggg
     4501 ccgggcatgt cgatcgggta gccgactatt acgacgccaa tactcgaagg ttcctacttg
     4561 tcaatgagtc ggatgccggc gctattcacc gctgcgtgtg gaccccggat gcggccaacc
     4621 cccgacgaag ctgcggacac cgtcaatcgc ctggtgctag aacgcttgca gggtcacctg
     4681 ccgccggacg gagggcggtt gctcgacctc ggctgcggcg tgggcgcgac catggtccgc
     4741 ttggcgcagg cgacgcaggc gcaggtgacg ggggtgacga tcagccgcgt tcaggccgag
     4801 gtcggcgaga agcggttggc gactgctggg gtggctgatc gctgcgagat catctgcctg
     4861 gactttgccg agctgcccac cgagcctcgc taccacgcca tggtgggcat tgaatcaatc
     4921 gtgcactcac cgtcggtggc cgatctagtt atgaccctgg cctcgcgtct tcacccgggc
     4981 ggccgcctta tcctgtgcga cgactgggcg accgacaagg accgtggcgt ggcggctcgg
     5041 gaacgttgct tggcacagtt ccgggccggt tggcgcatcg gtagcctgca cacggtggcg
     5101 gagttcgccg gtctggccga gcgcgccggc ctacgcctgc gtgaggactt ggacctcacc
     5161 tcgtacctgc gcctggggcg gccacgcgac cgcctagtca atgtggcact gggcgccgtt
     5221 cgggccctgc cgagggttcg cgatcgcgtg gtcgacattc cattttgggc caacatgatc
     5281 ggcggctcgg cgttgcagca ggggttgtcg cggcgttggc tggagtaccg tctgctgctt
     5341 cttgagcggg tataacgtca cctggtgttg gcgcagataa gctgatgagc tggccacgcc
     5401 cggcacgcct ggtcgcttgg acgctcttgc tggcggccgc cgttggccag gttcgggtct
     5461 ggtcctccga tcggggcttc tggctcgacg agttgtcggt cgccatcaac ctgcgcgagc
     5521 gggcgtggtc ggagctaccc ggcgggctgg agtactacca ggttgccccg gtgggttggt
     5581 tggcggtcac caaggcgttg cgagagtggg tgggcgaggc agaggtcgtg ctacgactgc
     5641 cgtcgctggt ggcaggggta gcgctgctcg tccttaccat ggtgatcgca cggcgggcgg
     5701 taggtgagtg ggcgtcggcc gtggcggtgg gtttggtggg tttctcacct acgctgctgt
     5761 actactcagg tgagctcaag cagtatgccg tggagacggc ggtcgcgctc ggtctcctac
     5821 tcctcggcga cgagttgctt cggcgggacc cgcagcgccg gcagggcgcg gagcaggaga
     5881 acggctggcg gtggccggtc ttggccgccg gtgctgggct ggttgcggtg gcggtgacat
     5941 tgagctacag cgcactgatt gtgctggccg gggtcaccgc agggctggct gcgatctttg
     6001 cggcgcggcg gcagtggccg gccatggcag tgctgttcct ggccgcggcg ccggccgcgg
     6061 cgctcggcgt tgggctggcg tggtaccgac ggctataccc gctggccccc aatcaggaca
     6121 cctggtttgc gcacggcatg ccagtgccgg gagccggcgt gggcgacgtc gtagcctggc
     6181 tgccgcagac ctggaccggt ttcgtcgcgt cgccgctggg ctggcgaagt ggctggtgga
     6241 ctctcgggct ggtggcgatc gggctggtcg cgctgctgcg acggggtcgg ggacactggg
     6301 cggcgatggc ggccggagtg ctggcgatgg cgatggtggc ggcggtgctg cgtggctacc
     6361 ccctcgccga ccgggtcgcc ctctacctgg tgacaccggt gatcttgctg gtcgtggccg
     6421 gcgtcgacgg cgtcgctcga ggggtccgct gggtcgccag gcagatccag ctggtgcccg
     6481 ccaccgccgc cggcaccgcg gcggcggtgg tggcggccgt tgctgtggtg atgcccgggc
     6541 cgccggtcgg cgacggggta cagcagatgc tggcgccacc cgaccgggac cgcggccgcg
     6601 aggtgctagc cgacctcgcc ggccgggtgc gcccgggcga tgtggtgatc gccaactggt
     6661 tcgccgaaca gctggggcgc tggtacgggc tggaggtcgc gggtctggtg cggatggcgc
     6721 cggccgagga tccgcagttg tgccgccctg actcggttga cgccctgctg gcgggcgcat
     6781 ctcgggcctg gtatctgcac ggcgccccgc ccggctccga gccggccgac cacacggtac
     6841 gagtggcggc gcagctcgcc cagcgcgggc gaatcgtgga cgcgtggacc ctgggcgagg
     6901 acgggttgag caacgaaccc ggctggatcc tgctggatct caccgccgga ccggacccca
     6961 ccccaccaac ggtcgagccg caccccgact tcgcctgcct caccgagacc gagggggtcg
     7021 cgaatgagca ccagctgacc cgcggcggcc gaagctagca ccaccggcgc gccggggctc
     7081 cgccactccc gccccgccga gttcgtgggg tgcgcggcgg gtacgccggc agtacagtac
     7141 gggcatgtcc cggtcgacgg accaggcgct gcggcggcgg ctggaccgtg ccaccgctgc
     7201 cctcgacccc ccgttcgcgg tggtcgacct ggccgccttc gatgccaacg ccgacgcgct
     7261 caccagcgcc gccgccggta ctccgatccg ggtggcgagc aagtcggtcc ggtgccgggc
     7321 gctgctgcgc cgggtgctgt cccgccccgg ctggcggggc gtgctcgcgt acacgctcgc
     7381 cgaagcgctg tggctgagcc gcaccggggt cagcgacgac gtgctggtcg gctacccgag
     7441 cgcagaccac ggctcgctgg tcgacctggt cggcgaccca gctgcactgg cgacggtcac
     7501 gctcatgatc gacgaccagg cccagctcga cctgatcgat gcgctggccc cgcccgccac
     7561 ccgggccgcg ccggtccggc tctgcctcga cctggacgcc tcctggcggc cactgcgccg
     7621 gctgcacgtc ggggtgcgcc gctccccgct ccacaccccg gcgcaggcgg gcgcgctcgc
     7681 cgcggccatc gctgcccgcc ccggctacgt actcaccggc gtcatggcct atgaagcaca
     7741 gatcgccggg gtgccggacg ccggggccag tccgcgggcg gccgcggtcc ggctgatgca
     7801 gcgccgctcc gaccgggaac tgcgggcccg tcggggcgcg gtggtcgctg aggtacgccg
     7861 gcacgcccag ctccggttcg tcaacggcgg cggcaccggc agcctggccc ggaccgtcgc
     7921 cgatccggcg gtcaccgagg tcaccgccgg ctccgggctc tacgggccgg cgctcttcga
     7981 cggctaccgg gcctggcggc cgacgccggc ggcgctgttc gcgctgccgg tggtgcgccg
     8041 gccttcgccg cggatcgcga ccgtcgccgg tggcggctgg atcggttccg gggcaaccgg
     8101 ccgcagccgg caaccgttgc cgtggctgcc ggccgggctc cggctgctcg gcaccgaagg
     8161 cgccggggag gtgcagacgc cggtgaccgg cgcggcggct gccgggctcg cccccggcga
     8221 ccgggtctgg ttccggcacg ccaaggccgg ggagctctgc gagcacgtca ccgcgctgca
     8281 cctgatcgac ggcgacgaga tcgtcgagac ggtcgagacc taccgcggtg agggggctgc
     8341 gttcggatga gcctcccgcc gctgacccgg cgccgctggc gcaactgggc cggcaaccag
     8401 cgcaccgccg gcgagctggc ccggccccgg acagtggcgg agctggccgc actgctccgg
     8461 tacgcgggtg cggcgggccg gcaggtgacg gtggtcggca gcggccactc gttcactagc
     8521 atcgctcgcg gcgccgacat ccaaatagca ctgtcgggga tggccggtgc catcacccgc
     8581 gggccgaccc cccggacggt gcgggtgccc gccggcacca ccctgcgcca gctcaaccgc
     8641 tggctcgccg cccaccagct cgcgctgccg aacctcggcg acatcgacgc ccagacggtc
     8701 ggcggcgcga tcgccaccgg cacccacggc accggcgccc ggttcggcgg gctcgccagc
     8761 caagtggtcg agctgaccct ggtcggtgcc gatggtgagg tgcggcgctg ctcggccacc
     8821 gagcagccgg acctgttcgc cgccgccacg gtcgggctcg gcgccctggg cgtggtgacc
     8881 gaggtgacgc tgcgctgcgt ggccgcgttc gtgctgcacg ccgacgaacg gccggtgccg
     8941 ctggcgcaga cgctggccga gttcgacgag tactgcgccg acaacgagca cgtcgagttc
     9001 tactggctgc cctacacaga ggcgacgctg gtcaagcgga acaaccgcgc cgccaccgac
     9061 agccggccga tgacccggct ccgggcgtgg tgggagaacg acgtcctgca gaacgtcgcg
     9121 ctgggcggag tgtgcaaagc ggggcgggcg gtgccagcgg ccgccccggc gctggcccgg
     9181 ctgatggcgc gggccttcac cccggtcagc tacaccaacc gctcggaccg gatcttcacc
     9241 acgccccgcc gggtccgctt cgtcgaactt gagtacgccc tgccgcgggc agcgctgcca
     9301 gcggccttcg ccgagctgcg gcggatcgtg gcccggtcgc cgcagcgggt gctgttgccg
     9361 gtggaggtgc gggtcggggc gggcgacgac agctggctgt cgccggccta ccagcgcaac
     9421 tgcgcgtacc tggcgatcca ccagtatgtc ggcgccccgt accagggcta ttttcaggcg
     9481 gtggagcgcg cctgtgccgg gctcgacggc cggccccact ggggcaagct gcactggcgc
     9541 gacgcggaat cgctcgccac cgcctacccg cgcttcgccg acttcctggc ggtaagggat
     9601 cggctcgacc ccggtcgggt cttcggcaac ccgtacctgg cccgggtgct cggcccctga
     9661 cgctgctcgg cccctgaccc gcctggccag gtcgtccagt cgccgtccag caccgggtga
     9721 tagtcagagg gcggccggac acccccggcc acagtgaggg aacccctcag gacctgaagg
     9781 gagtggtaga gatgagcacg ctggctccgg aacgcaccgc ggcagagacg gtcgacgcct
     9841 ggcggcgcgg cctcgacgac agctgggaga acccggccgg gccccggttc ctcggtgact
     9901 acaccgaatc ggagatcacc ctcaccggtg gtcagaccaa cgaccccgcc accatgggca
     9961 gtctctgcac cgggggcatc tgcaccgcct gctgctgacg atgacgaccg acgcggtcga
    10021 ggtggccctg cggggcgatg tcgaccggat gctgagccgc ctggtggagc cgccgctggc
    10081 gaccctggcg gcccagctcc ggtcgttggg caccctgagc gaacccgagc agcaggtgct
    10141 catcgccggg gtccgggatg gcctgaccca ggtggcctgg cgccgagtca gccgggtggt
    10201 gctgctggag ctcaacgccg cccgggtgac cggccagctc accgccgacg acgccgacgg
    10261 ccgctggcgg gagtgggtgg cccggctcgc tgaacccgac gggtgggaac gcgtcgccgc
    10321 gccgtacccg ccgctgctgc cgcagctgtg gacgctgatc ggcaaccggt gcgccgccgc
    10381 gctgcggatg gccgaccggt tcgggcgcga ccgcggacgg ctcgggcagc tggtcggcgg
    10441 cgccctcggc gagctgcagg cgatctccac cgacgccggc gacagccacc gcggtggcga
    10501 gtcggtcacc atcctccgct gcaccggcgg cagtgttgtc tacaagccac gttcggtccg
    10561 ggtggacgcg gcgctcgacc ggttcctccg gcaggtcctc cccgacgagc ccgaaccgag
    10621 ccggatccga gtgccggcgg tgctgcccag ccccgaggat cggtacggct gggccgagta
    10681 cgtcccccac gtctactgtg ccgaccagga gcagctgggc accttctacc gcaaccttgg
    10741 ccactggttg gcggtgatgc gggcgttggc cggcagcgac ctgcacaacg agaacgtcgt
    10801 agcgtgcggc ccggtgccgg tcgtggtgga ctgcgagacg ctcttcaccc cgccggacac
    10861 ctcccgcccc tccgggttcg gcgaggccct tgacctggcc gccgcccaga cccgacagtc
    10921 gctgctgcgc accgggctgc tgccgggacg gcaggcgttg ctgggttggc ggggcgtgga
    10981 cccctcggcg gccgggttcc tccccagcga acaacccacg gtgcaggtcc ccaccatcgc
    11041 cgacccgggc actgaccggg cccggctcac gctcaccact ggggaactgc cggcgagcgc
    11101 caacctgccc agcccggaac cggacctggg cgggtactgg caggcggtag tgggtggatt
    11161 cagcgaactc acggaggtgc tgcacgcccg cgacgcacac ggggagctgg caccactgct
    11221 ggccgagttc gccgactgtc cggtccgggt ggtggtgcgg gacaccaccg cgtacaccga
    11281 actgggtcgg atgctgtggc acccggcctc gctgcacgac ccgccgccgg cccgccgccg
    11341 ggcggccgaa ctactggtcc aacacgcgga gaaccggccg ggcgcccccg acgcggcggc
    11401 ggtggtcgaa gcggagatcg acgagctgct cgacggtgat gtgccggtct tcaccaccac
    11461 accgggcacc ggggtactca ccggcccccg gggcaccacc ttcggggaac cccgcgatct
    11521 ggtcgccgag acgctgcacc gatggcggca gatgcgaccc gaggcggaac gccgggtgat
    11581 ccgggccgcg atggtcgggg cctacctgaa cgacggctgg cgccccggcc aggaccggct
    11641 cccgtcggtc acgccccgcg ccgacgggtt ggaccggcga cgacgggagc aggcggccac
    11701 gatcgtggcg aggatcgcca cggaggcgat ctggggtcgc gacggctcgg tcacctgggt
    11761 ggccccggta cgctccagcg ccggctgggc ggtccaacca ctgcccaccg acctgtacgg
    11821 gggcgggttc ggggtggcgg tggtgctcgc cggctatcta cgggaagttt cccagagccg
    11881 ggccgacccg gtgcccgggc tcaccgaact gctcgccgcc gtggtccaca ccatccgcct
    11941 cgccgaagac cagcagcggc gacagcaggc cgacgcggcg gcgctcgaca tccggatccg
    12001 ccccgacccg cccggcgggt acctcggcat cggctcccgc atctggggct ggctactgct
    12061 gcaccagctc ggcgtggtgc cgggcgacga ggcgcggcgg cgggccagcg ggttggcgga
    12121 gctgctgccg gcggcggccg ccgccgatcg ggaacatgac ctggtgaccg gttcggccgg
    12181 ggcgatcgtg ccgctgctgg cgctggccga ccaggttgac gcggctcccg ccgacgccgg
    12241 agccggcacc gatagcgact ccggtccgcg gctgcgggcg ctcgccggcc aactgggcga
    12301 ccggctgcag gcttcggcca gccgggccgg cgccggtgcc ggctggccca ccgacgcgta
    12361 cccggacggc atcggtggtc tgtcgcacgg tgccaccggc atcggttggg cgctgcgccg
    12421 gctcgccgac gcgaccgggc gggccgagtt cgccgagctc gccgaagcgg cgttcacccg
    12481 ggaagcgtcc tacttcgacc ccgacgaggg tgcgtggcgg gacgcccggg agggcaaacg
    12541 gcacggcgcg gcgtggtgcc acggttcggt ggggatcggc atcgccgccg atgacctgct
    12601 gggtcggcgg ggctccggcc ggtgggaagg ggtgctccgg cacgccgccg cgcacgcctg
    12661 ggccgacggc ttcggctgga cccacacgct ctgccacggc gacctcgggg cgtgggagtt
    12721 gctggcccgc gcgtcggcgc gagggctcgg cccacccggc gtcaccgcgg agctggtggc
    12781 cgcccgactg ttgaccactc tggaggaaca cggcccgatg agcggcatgg ctcgggacgc
    12841 tttcgcgccc gggctgctag ccggcgaggg tggtgtcgcc taccagctgc tgcggctgca
    12901 tccggagtgc gacctgccct cggtgctgct accggtcccc gcttcccccg gccgacccac
    12961 cggccgaccc accggccgat catgagcctg tgaaccgaca cgccgggtgt gtcgggttca
    13021 tccgctcatg atcgaccgta gggctgggtc agtcgaccga gtctgggctg tcgggcgaat
    13081 ccggggaatc cggactgtcc ggcgagtcag gcgagtccgg agaatcgggc gagtcgaatg
    13141 gcgaatccgg actattcggc gagtccgggg aatccggcga gtccggggaa tccggcgaat
    13201 ctggtgagtc gaccgagttg gccgagtcgt ccacgccggt caggttgacg ttctcgacct
    13261 gacccggctc cgaccggtcc tgcaggggga tcccgtcagc gagggcagcg gtcgccccca
    13321 acccgacgat cgccgccgca gtgccggcgc ccgcgatcac ccgccaggat ctacgcatag
    13381 ccatcgttgt tccctcctca atcgctccgc gaccgttcgc ggtgcgtggg atccagcttc
    13441 gccaaccgcc atgaggagcg gctgaggtcg gcatgagagt ggcctcatcc ccgccttact
    13501 gcccgggcac tggtcagcca gcgctccgcc aactcgaccc ggtacctggt gctgcgctgc
    13561 cagcccgact cctgcacccg atagggcccg gtggccagcg acaacaccac cgccgccacc
    13621 cggtagcgca gatccgccgg gtccacccgc tgctcgaagg cggccaggta gcgcgccccc
    13681 gcccggctca ccgtcgccgc ctgcgccgga ttgagctgcg tcaacaccga caggtggccc
    13741 agcaggcagg ccaggtcgtc gagccggtcc ccggccccgg cggtgtccag atcgaggagc
    13801 ccggtgatcc gaccacccgc cacccacacc tgattctcgt agaagtcgcc gtgcaccggc
    13861 acaatcggac cggtgccgcc ctcggcgtag atcgccgcgg ccagctcccg cacccgctct
    13921 gcctcccggg gcagcaccga ggccacggcc gtggcgtagt ggccggcccg atcccgccac
    13981 gaacggcgta ccggcgcgtc ggccaacccg gccggcagcc ggtccaacag cgccaggatg
    14041 gcggcgccgg tcggcagctc cgctgcctcc gcccgcagct cctgccgcag cgagtggccg
    14101 ggcagcgcgg cgagcgccac caccccgtcg gcgctgtggc cgaggctcgg cggcaccggc
    14161 acgccggcgt cggtgaacct ggtgtgctgc cggtgcagcg tcgctgcctg cgccggcggg
    14221 acgaccttga ggaacagccg gtggccggtg gcgccgatcg cctcgatcac cgcgcgccgg
    14281 tgcggccggt aggcgcgcac ccgcagccgg ggtggctcat ccccggccct cgccaggtcg
    14341 aacgagcgca gtaggccggc caccgccgcc gggtcgtagg cggtggccaa ccccggcagg
    14401 tacgggtcgt gcgggaaccg ccacaccgcc acccggtcgg tcccgtcgcc gatcaccaac
    14461 gtgtcgggtg ggggcggacc ggcgccggcc caggcgccga agcgctcctc ggtctcctcg
    14521 ccggtcggcc accggacctg gacccggtac gcggcggtgc tgccgttgcg gcggtgctcc
    14581 acctggtggg cgcgccagga gagcaggtgc ccaccgaccc cgaccaacgc ggtctgcaga
    14641 atgtcccccg cgtcggggcc ggtcagcagc tcacgccagg gctgcccggg ggcttgcggt
    14701 gctgcggtca cgggcatgcg gccgagtctg tcggaggcag atgagcgcac ggtaagccgt
    14761 acctgagaat cttctcatct ggcctgcgta cgcggatcga gcttaggcgg cgaagcggta
    14821 acccatcccg cggaccgtct ggatcacgtc ggcgccgagc ttgcgccgca gatagccgat
    14881 gtatacatcg accacgttgg agcctgggtc gtggcccaag ccccagaccc ggtcgagcag
    14941 ctgctcccgg ctgagcacct gccccgggtg ccgggcgagg gtctcggcga gcaggaactc
    15001 ccgggcggtc agctccacct ccgtaccgtc gacgctcacc gtacggcgga ccaggtcgag
    15061 ctggatcggg cccaccgcca gcgtggtggt ggcggcctgg ccctggtcgc gtagccgggc
    15121 acggacccgg gcgagcagct cctcgaagct gaacggcttg gtcaggtagt cgtcggcgcc
    15181 ctggtcgagc ccggccaccc gatcccggac cccgtcccgg gcggtgagca cgatcaccgg
    15241 caacctttca ccgcgcgccc ggacctgggt cagcaccgcc aacccgtcct gcccgggcag
    15301 gcccaggtcc agaatcatca ggtcgaagtc gtcgctgcgg gcgtaaccgg cggcgtccac
    15361 cccgctggtc accaccgtgg tgacgtaccc ggcggcgcgg agcccctttt cgaggaacgc
    15421 cgcgatccgc ggttcgtcct cggcgatcag cacccggttc acgtcacgcc cccatctcat
    15481 ccggcccagg tggccgggtc agcggtaaca gcaaggtgaa ggtggagccc actcccagct
    15541 cgctcgccac cgtgacgcta ccccggtggg cggtcgcgat cgcggtcacg atcgccagcc
    15601 ccagcccgac cccgtcggcg ccccgaccac cgcggatacc ggacgagtcc gcccgaccga
    15661 accgctcgaa gatcatctcc cggtccgccg gggagatgcc gatgccggtg tccgagaccg
    15721 acagcgccaa ctcgccgtaa tacgcctcgg cggcgagcgt aatccggtcc ccggcctcgg
    15781 tgaactggac cgcattctgc accagctgca tcagcgcctg ggtcagccga tgccggtcgg
    15841 cgagcgtcac caccgcgtcg acccggccga gctgccagtc gcggtcgccc aacgcggtcg
    15901 ccttggtgta gacctcggag agcacggcgg ccacatcaac ctgggcaagc tggaggaagt
    15961 cgggccgctc cgcccgggcg agcatcagca gatcgtcgac catccggttc atccggtcca
    16021 gctcgtcggt gaccagtgcc accgtctccc ggcgctcctg cgggtcgtcg cccatcacct
    16081 ccagatgccc ccggacgatg gtgatcgggg tgcgcagctc gtgcccgaca tcgctcagga
    16141 agtcctgctg ggcggcgaac gcacgctcca gccgccccaa catcccgttg aaggtccggc
    16201 ccagatgcgc cacctcatcc gagccgctga cctcgatccg ccgggaaagg tcgctctcct
    16261 cgatctcccg ggccgcctcg gtcaccgtcc gcagcggccg caacgcccgc cccatcgcga
    16321 gatagccgcc ggccgcaacc accacgatca ccagcaggca ggcgaaggcc atcagctgca
    16381 ccgcccggtc gatctcggcc cggcgctcgg cggtgaactg gaccaccacc acgtgtccct
    16441 gcaactcgtc ctcgatcgtc accggcaccg ccagccagcg ggccccgccc gccgggctct
    16501 gctcaatctc gccgtactgg ctgctgcgca gcgacgtcca agagttggtc agcgccgggt
    16561 cggtggtcag gtcgaacggg gggtccgggc tggcgccgta gaaggcaccg ttgacgaaga
    16621 tgaagaccgc ctcaccctcc tgtggctcgt tccgttccag gtaggtgtcg gcgatccggc
    16681 cgagatcggt cccgaacggc tcaccggtgg tcggatcccg cccaccggcg agcagccgaa
    16741 actcggacac ctcctgttgc aggtcggcgg tggtccggtt ctccagctgg ttgagcagca
    16801 cctgccggac gacgaccacg gaccccaggc tggcgaccgc gagcagcagc agcgcccagc
    16861 cgagcagccg cagccgcagg ctcaccaccg ggcgccaccg ctggtggcgg tcagtcgtcg
    16921 tcatccaccc catcgtcgtc cggactcacg tctgcgctgg tatcggggct gtcgtgatcc
    16981 ccctcactgt cgctgctgtc ggggctgtcg gggctgtcat ccgggtcgcc gggggtgccg
    17041 acggtgccgg gctcgggtcg tccccggggc accgggtcgg gggttccggt cgactcatcg
    17101 tcctctcccg tcgacagcga gatctccccc accggcgccg gcggcaccag cgtagggatc
    17161 cccacgctca gaaacagcgc ggcgagcgcg gccagtgcga cggcggtggc caccttctgc
    17221 gcactcatcc ggagagcatc accgaccggc atgccgcccc gatgagggcc acatgagaaa
    17281 acccttaccg ccgccgcgcg ccggctgtca tgctcgccga gtcactaccg acggaggcac
    17341 ccgcggatga gccggtttct gaccgagatc ccgctggcct cctccgggcc gtgggagccc
    17401 ggcgtacagg aggcaatccg cgccgggctc gcggcggccg acgcccaccg atagcccgct
    17461 tcgcggcagc gccgtggtcg gttgccctcg tcaggggccg gtcatgggtt cccggggggc
    17521 cacgatgagc cgctgggaat ggagttgttc gtagaagggc cggtgacggg cggcgaaccg
    17581 cgccagctgg tcggagttct ctgtggtgtg cgggtacctg cggtcgcggt gctggaatcc
    17641 ggagctggcg ttgacgtcgg tgtgccagcg tgctgaccgt cgccactcag ggcgctcacc
    17701 aggttcccaa ctgagcgcct gcgggatgaa cggcagaaac aggccaacct caggcggctg
    17761 tccggccagc caggtgagca gcgacgcggg cgactcgaag gtccggccgt cgagatctgt
    17821 ttcgccgtag tccgccaggt tgctgaacgg ttcatggagg gcggtcaggt caccgcgctc
    17881 gagcatcgag cggaagaaaa ccgtcgagcg tgctcgtggt gcgctccaca atgcgtatac
    17941 cggcagcaac gttggcccta cggatccagc agctgttccc gcaggatgtc cgcgtgcccg
    18001 cagtgctgag cgagctcccg caacacgtgc agatacaccc agtgcagcgg gagcgggcca
    18061 cgccggttgc cgtggaccat gtcgtccagt tcgagcgatg cggtcaggat ccgggaagcc
    18121 tcgcacgctt cccggtacgc ttgctggacg gtggcgatgg tgtcgtcgtc ccccaggatg
    18181 aaggactctt cgggtgtctc ggggatgccg ttctcggccc gcggccggca cgtgattgcc
    18241 tcgtcgaacc agaccttctc aacaaacgtg gcgtgcttga ccagaccgag cagcgtccgg
    18301 gaggagacca gggagcgacg agcctgttcc tcggtcagcc cggccacaca gtcatgaagc
    18361 gcccgccgat gctggtcgag gaaggcttcg aactgggctc gtggcgactg gccgatgacg
    18421 tcttcggcgg agacggctgg cagggaagac atgctgggag cttcgcaagg ccggcacccg
    18481 cgagcaactt gatcgccact gatcttcgct ggcccggcca ttggagtcgg acgatcgact
    18541 cgggagggcg ccgacatcgc cggtgccggc tccagccgat aatgcaggcg cagcacgagc
    18601 gcccgataga gccgcagctc gtggtcggtg cgcagcacgc catggccatc tcggtagacg
    18661 tggaagcgct catggatggg gacccgggcg gcgtaggcca accgggagcc ctgaaccacg
    18721 acataggctc cctcgctgcc gaaggccccg gccggcgacg acagcaccaa cgagccgtcg
    18781 gcctggacac tgggccggag gaagacctgc acgttgccgg attgcaacgg gaacgtgacg
    18841 tgcaccgagg gctggtcgga acccggcaac agccgcgctg agtagcagcc gctgtagacg
    18901 aactcgccgg tggcggacaa ggttcgcagc cagccggcgg agagctgatc gccgttcgcg
    18961 tcgaccacat gcacgacgcg cgagtccatg ccgtgcgcga cgtcgagggg acgggtgggc
    19021 agcgcgagct gctggacacg acgcccgaag caccgaccta ccagctcccc gcccggctgg
    19081 aacagggtcg accactgcgc ccagacctcc atccgccagc atgcggtctg ctcgtagaag
    19141 tcccgaaccc ccgggtccag atcgttggca cgaaacgtcg cgccgtccag caccgacatc
    19201 gacgacaaca gcccaccggt ggggacgtcc tcacgcacgg caccaccggt ccgcgcagcc
    19261 tcagcagcga gccacgaggc ccccaccggg ccaggtccgc acaccggcgc ggctagccat
    19321 cgatggtcgc cggcgagact cacccggcgg ccgaccagtc gccaccaggc acgtgtggcc
    19381 gggtccagca ctctgcccaa ccgcgcggcg gtcacgtggt ctcctccctt gaccttcgca
    19441 gccctactcc gggcggcgca ggaccagcaa caacggcggc ggaagaccgt cccaccgccg
    19501 cctttgaccg gcgcgcgcct cggccagcag gttgtcggcg gcacggtcgc ccaactcgct
    19561 gcgcagctcg tcggcgttcg ccaaccagat cgcgtagagc cgctgccagt gctggtcgtg
    19621 atacgggttc ggcagcgcgt cctccaccac gaggcccgcg gccagcgcca tggcttgcca
    19681 gtccttgccg acgacacccg gccggctgcg taccgtcagc gcgcaccgtc cgcccgccgc
    19741 caggatccgg tgcacctcac gcagcgcggc cggccggtcc tcggcgatcg gcagcgcatc
    19801 gatgctgacc accccggcgg cgctgccgtc tggcaggccg gtctggtcga acgtggccac
    19861 ccggaactca gcccgacccg gtgggacgaa ggccgccacc cgccgcttcg caagctccac
    19921 tgcggccggg ctgaagtcga ccccgatcag ccgcagcgac agcgcccggg ccaaccacag
    19981 acccggtccg ccgcggccgc aacccaggtc gaccagcagg tcatctggct gcagccgtag
    20041 cgtcgagacg agctggccca gcagccacca ggtacatgag ctgaatggct caacctccgc
    20101 ggggtactgg tcgcccatcc cttcggcgta cagaagccgc atcagtgcgc catcgtggag
    20161 cgcggtgtgg gtggcgtcgt agtcatccgg cgcggtgccg atagcctcgg tcatccggcc
    20221 attctgccga caacgctccg cgaacccaag gagtctcgat gtccctcgat gaccaggtgc
    20281 tccccgagga tgtccggcgc gatagccaag ctggctggcc gccgcggccc gtgggcgagg
    20341 gctcgccctt cgagcccttc ggctggtatg ccagctgtct ttcgaccagc tcggtctcga
    20401 ccagctccgg ctgtggacac atgccgacaa cgtagcctcc cggcgggtcg ccgaacgagc
    20461 cggcttccat cgtgatcccg aacgtgacca gcggaagcag ctcaaacggg ccgtctggga
    20521 gacggtcggc tacgccctcg ggtccccgcg ccggcaagaa aagtaggcca ttgaagggcc
    20581 cgcgcgaggc tgggccgtcc cgccaaaaat tgcttgtcgc gcaccgggta ttgcgagacc
    20641 ctggtctcca tgacgttctg acggcagtgc ccactcgctt cgaatccgcc accgcgccga
    20701 cctgcgcagt gctgcggctg cccgttatcc ttctttcacc ataagagagc gtcgtgtctc
    20761 agttgcactc ccggcagcag cagtcgctgc cgcactccac cccggccacc gattcggcaa
    20821 ccgtcaccgt gttcgccgcc tccaccagct ggatcgagtc cgatgccgtc gcccaatgcc
    20881 accaggtggc cggcttcgac ggcatgatcc atgttgccgc catgccggat ctgcaccccg
    20941 gcaagggcgc ccccatcggc gccgccatga cctcgaccgt gctgtacccc tccctggtgg
    21001 gctccgacat cggttgcggc atcgcggtgt tccccatcca actcaagcgc gccgtgccgg
    21061 agaggctggc cgcccggttc cccgacctcg accgggcgct cgaccccgag cgggacgccg
    21121 acgacccggc ctgggaggtg gtggacagcg acatccccac cgggcatgtc gagggccttg
    21181 ggacagtcgg ccggggcaac cacttcgttg agctggcgcg gatcgacacg gccttcgaac
    21241 cggaccacgc ggaccggctt ggcatcgccg ccggcgacct cgtactcatc gtccacagcg
    21301 gatcccgcgg gttgggcgag cggatcctgc gggcgcacac cgaggtccac agtgccgggc
    21361 cggcgccgga tcccgccgcc tacctcacca tgcatgatca cgccgtacgc tgggggtcgc
    21421 tcaaccggcg gctgatggcc gcccgggtcg cccacgccct gggcgccgaa cccaccgaac
    21481 cgatcgtcga ccagtgccac aacctggtcg aggtccgcga tggggtctac ctgcaccgca
    21541 agggggcggc gccgggtaat ggccaggacg tgctcatcgc cggcacccgc ggcacccctt
    21601 cctacctcgt cgccggtcac gccggcccgg aggccaactt ttcggtggca cacggcgcgg
    21661 gccgcaagat gtcccgcgcc gacgccctgc gccgaggccg ggccaagcac accgtcgccg
    21721 agctgcggcg cacaccggtg ggctcgctgg tggtctgcgg cgaccggcag ctgctcttcg
    21781 aagaggcgcc tggggcgtac aaacgcatcg agcaggtgat cgccgacctg gtcagccacg
    21841 acctggccac ccccgtcgcg acgacggtcc ccctggtcac gtacaagacg gcggatgttg
    21901 cgtccaagcc acggggcgac cgaagggacc accgacgcag ccggggcggc cggcggtgag
    21961 ctcacagact gcaccacctt atggccgacc acgggccgca ggtgtacgta ccacgtacga
    22021 ccagtcggag gcgaccatga tgttcaagag cgaggacgac gcatggcggg agaccgagta
    22081 cctgtcccgt ggcgccaacg gccgggaact tcgccggcgg atggcggcgg tggaagcggg
    22141 ccggcgctcg accgagggca gtaatggggc tgatcaaacg cgagggtcat gccatgatcg
    22201 cccggtgatc gaacgacggc agtacaccga acacggcgat cgggaaatcg cactgggtgg
    22261 agagatcctc cgcacggtgg tgggttccgg cgtgcacggc atcgcgatcg ccggcaccga
    22321 cgaccacgac gagatggggg tcttcgtgga gccaccggag gcggtcatcg gcgtgcgccc
    22381 acccgtggat cattacgttt accggacgca gccggaggga gcccggtccg ggccgggcga
    22441 tgtcgacctg gtgatgtact agctgcgcaa gtatctgcgt ctggcggcca agggcaatcc
    22501 gacggttctg ctgctgctgt acgcgccgcc cgaatcggta ctggtctgcc agccgctcgg
    22561 ccgacagttg cgggagttgg cgccggccct gctgtcacgc agggcggtcc accggttcgt
    22621 cggctacctg ggttcacagc gccagcggct gctggggcag ggcaagcagg gccgggtacc
    22681 gaatcgacca gagctggtgg cgaggtatgg ctacgacgtc aagtacgcct cgcacgcgct
    22741 gcggctggcg tatcagggct tggagatcgt ccgggacggc cggctgaccc tgccgatgcc
    22801 cgagcgggag cgggagcggg tgctgcgggt caaacgcggc gacgtgccgg tcatgaccga
    22861 cgtgttggag gagatcgacg ctgtacagcg ggagatcgaa acccggctgg ccgacggccg
    22921 tacgccgttg cccgcccagc ccgactgggc cgccgtctcc gcgtggtcgg tcgacgcgca
    22981 ccggc
//
