LOCUS       NZ_CP070499            23042 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Natronosporangium hydrolyticum strain DSM 106523 chromosome,
            complete genome.
ACCESSION   NZ_CP070499
VERSION     NZ_CP070499.1
KEYWORDS    RefSeq.
SOURCE      Natronosporangium hydrolyticum
  ORGANISM  Natronosporangium hydrolyticum
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Natronosporangium.
REFERENCE   1  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Natrosporangium hydrolyticum gen. nov., sp. nov, a haloalkaliphilic
            actinobacterium from a soda solonchak soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) Bioinformatics, Leibniz Institute DSMZ,
            Inhoffenstr. 7B, Braunschweig 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-MAY-2020
            Assembly Method                   :: HGAP v. 4
            Assembly Name                     :: 999_Micromonospora_sp_DSM106523
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 580.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016925615.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 06:45:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,188
            CDSs (total)                      :: 5,131
            Genes (coding)                    :: 5,046
            CDSs (with protein)               :: 5,046
            Genes (RNA)                       :: 57
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 85
            CDSs (without protein)            :: 85
            Pseudo Genes (ambiguous residues) :: 0 of 85
            Pseudo Genes (frameshifted)       :: 18 of 85
            Pseudo Genes (incomplete)         :: 72 of 85
            Pseudo Genes (internal stop)      :: 4 of 85
            Pseudo Genes (multiple problems)  :: 8 of 85
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:11:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3649703
            Orig. end                         :: 3672745
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070499.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23042
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="17"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23042
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23042
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13042](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13042)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(502..1029)
                     /locus_tag="JQS43_RS16300"
                     /old_locus_tag="JQS43_16235"
     CDS             complement(502..1029)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS16300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_16235"
                     /product="hypothetical protein"
                     /protein_id="WP_239675252.1"
                     /transl_table=11
                     /translation="MTTPPDRPGPPPGPGVQPPFVAAPIEGRRLRIGVGLGVAGALVAA
                     CCGVGAVAGGGLLVLGQQVINEQAQRPVGEFVGALADQDWETAYDQRCAADRNTEPLSQ
                     FSSRMQALPAIDDYQVGDLEIEPGDDVFGTGDMRVPVDVAYVDGTDTVLDIPVEQNVET
                     GEFEVCGTFTPE"
     gene            complement(1013..1357)
                     /locus_tag="JQS43_RS16305"
                     /old_locus_tag="JQS43_16240"
     CDS             complement(1013..1357)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287942.1"
                     /locus_tag="JQS43_RS16305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16240"
                     /product="antibiotic biosynthesis monooxygenase family
                     protein"
                     /protein_id="WP_239675253.1"
                     /transl_table=11
                     /translation="MLALNRFVVPPERTAEFTAQAQQALAVFAARPGYQGGELTRALDD
                     PAHWCLLTRWASVGAYRRALGHFDVKMYATPLLASAEPDPAGFEVLAEAAPEGPVTRYD
                     SDRAEHDHAA"
     misc_feature    1403..1416
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.07"
                     /tool="antismash"
     gene            1440..1721
                     /locus_tag="JQS43_RS16310"
                     /old_locus_tag="JQS43_16245"
     CDS             1440..1721
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287943.1"
                     /locus_tag="JQS43_RS16310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16245"
                     /product="hypothetical protein"
                     /protein_id="WP_239675254.1"
                     /transl_table=11
                     /translation="MTPNPDDDRPATSDLLARLNRANPTLVVFGALAIFLGILFLPDLW
                     GALLVLVLVGALGWLLSRTWPVLTPAARGIRLAVIALLLLVALLKLTT"
     misc_feature    1750..1765
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.69"
                     /tool="antismash"
     misc_feature    complement(1752..1766)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.55"
                     /tool="antismash"
     misc_feature    complement(1753..1768)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.7"
                     /tool="antismash"
     misc_feature    1756..1771
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.32"
                     /tool="antismash"
     gene            1788..2882
                     /locus_tag="JQS43_RS16315"
                     /old_locus_tag="JQS43_16250"
     CDS             1788..2882
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1252: cation ABC
                     transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018815423.1"
                     /locus_tag="JQS43_RS16315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16250"
                     /product="metal ABC transporter substrate-binding protein"
                     /protein_id="WP_239675255.1"
                     /transl_table=11
                     /translation="MLRRSLAYASTGLLLGAATACAADAEEGSDEAAVDVVAAFYPLEF
                     VADRVGGERVSVTGLAPPGVEAHDLELTPSQVAEISQSDLVVFLTDFQPAVDAAVAEHA
                     DDRGFDVAEVVPLLDNPDGHDHDHGHSHDDEDAREDDHDHDHDHDHDDDHDHDDDDHGH
                     DDDHGHEDDEDGHEEDDEHGDDDHGHDHGDQDPHVWQDPDRLATIADELAVELGALDAD
                     YADEYAANAAALREELDTLDQEYADGLAQCERREIVVSHAAFGYLSDRYDLRQIAISGL
                     SPEDEPSPQRLAEVIREAEAHGATTIFFEVLVSPAVAEVIATEVGAETAVLDPIEGLAP
                     GSEEDYFSLMRANLDTLRGALDCT"
     gene            2879..3670
                     /locus_tag="JQS43_RS16320"
                     /old_locus_tag="JQS43_16255"
     CDS             2879..3670
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019869094.1"
                     /locus_tag="JQS43_RS16320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16255"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_239675256.1"
                     /transl_table=11
                     /translation="MSTPVLELAHGVVGYHGRPVLPGVSLRVNAGEVVAILGANGSGKS
                     TLIKAALGLLPLTAGSARLFDTPLGRFRQRYRLGYVPQRAGAGSGVPATVTELVSAGRL
                     PRRRLPWPRWSADRAAVTHAIAVVGLTEKRREPVGTLSGGQQQRALIARALACEPELLV
                     LDEPTAGVDAASQVAFAGALRHFVDAGGTVVLVAHELGPLAPLITRTVVLHEGRVVQDT
                     AGAAVATDSTTASDPGTGHHDEPPAPSPVGWQPSLIQELPR"
     gene            3667..4542
                     /locus_tag="JQS43_RS16325"
                     /old_locus_tag="JQS43_16260"
     CDS             3667..4542
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_process="GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1245: ABC transporter
                     protein, integral membrane"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019869095.1"
                     /locus_tag="JQS43_RS16325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16260"
                     /product="metal ABC transporter permease"
                     /protein_id="WP_239675257.1"
                     /transl_table=11
                     /translation="MSIFSLPFMQYALIGALITGLVAPALGTYLVQRRLALIGDGIGHV
                     ALTGVAVGLLLAQSPVITAMVVAAAGAIAIELVRERGKTSGDVALAVLFYGGIAGGVFL
                     VNLSASHTNANLMAYLFGSPLTTSPADLRIMAILGGAVLLVTLGLRPWLFAICHDEEHA
                     RVSGLPVRALNLLLAVTTAVTITVAMRAVGLLLVSALMVVPVATAQLVARGFRATQLLA
                     MAIGVAAAAAGIWFAGVYDTAPGATIVLLAIAGFAVVTVVTAGWRWLRRGRDRRPGEPV
                     VPPPEVTLAR"
     gene            4559..4897
                     /locus_tag="JQS43_RS16330"
                     /old_locus_tag="JQS43_16265"
     CDS             4559..4897
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014646.1"
                     /locus_tag="JQS43_RS16330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16265"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_239675258.1"
                     /transl_table=11
                     /translation="MGGNEAYEAAGELLRALAAPIRIAIVTELADGQRCVHELVDALGV
                     AQPLVSQHLRVLRGAGVVKGARRGREIAYTLVDEHIAHIVADAISHAGEQRPGEVPTVE
                     MAREVRAP"
     gene            4894..5298
                     /locus_tag="JQS43_RS16335"
                     /old_locus_tag="JQS43_16270"
     CDS             4894..5298
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1266: hydrogen
                     peroxide sensitive repressor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020512691.1"
                     /locus_tag="JQS43_RS16335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16270"
                     /product="Fur family transcriptional regulator"
                     /protein_id="WP_239675259.1"
                     /transl_table=11
                     /translation="MTATTDTPGVRHTRQRAAVSTLLNEVEGFHSAQELHAMLRERGER
                     VGLTTVYRTLQGLADGGEVDVMRPPGGEHLYRRCSEGHHHHLVCRACGRTVEVEGPAVE
                     TWASKVAASNGFTEVSHTLEIFGTCPACAG"
     CDS             5384..5599
                     /gene="allorf_3655087_3655302"
                     /locus_tag="allorf_3655087_3655302"
                     /protein_id="allorf_3655087_3655302"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVLRECLLCVRNAIGRAVGLQDRRADRLTRLGGSSGAWFANMNLV
                     CRRSGSPLNRPSGRRCDSRRQGGAPS"
     CDS_motif       5384..5494
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MVLRECLLCVRNAIGRAVGLQDRRADRLTRLGGSSGA"
                     /locus_tag="allorf_3655087_3655302_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       5495..5599
                     /prepeptide="core"
                     /locus_tag="allorf_3655087_3655302_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.20"
                     /molecular_weight="3700.1"
                     /monoisotopic_mass="3697.9"
                     /core_sequence="WFANMNLVCRRSGSPLNRPSGRRCDSRRQGGAPS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVLRECLLCVRNAIGRAVGLQDRRADRLTRLGGSSGA"
                     /leader_location="[5383:5494](+)"
                     /alternative_weights="3718.2"
                     /alternative_weights="3736.2"
                     /alternative_weights="3754.2"
     CDS             complement(5541..5645)
                     /gene="allorf_3655244_3655348"
                     /locus_tag="allorf_3655244_3655348"
                     /protein_id="allorf_3655244_3655348"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MARVLGSYAQGHQAAIRKGPLPVAGCHTVGRLVG"
     CDS_motif       complement(5625..5645)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MARVLGS"
                     /locus_tag="allorf_3655244_3655348_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(5541..5624)
                     /prepeptide="core"
                     /locus_tag="allorf_3655244_3655348_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.20"
                     /molecular_weight="2739.2"
                     /monoisotopic_mass="2737.5"
                     /core_sequence="YAQGHQAAIRKGPLPVAGCHTVGRLVG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MARVLGS"
                     /leader_location="[5624:5645](-)"
     CDS             complement(5778..5912)
                     /gene="allorf_3655481_3655615"
                     /locus_tag="allorf_3655481_3655615"
                     /protein_id="allorf_3655481_3655615"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MWTSHSARLGGLGGAWFASMNLVCRLSGSPLNPPRQLAGLAQVG"
     CDS_motif       complement(5868..5912)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MWTSHSARLGGLGGA"
                     /locus_tag="allorf_3655481_3655615_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(5778..5867)
                     /prepeptide="core"
                     /locus_tag="allorf_3655481_3655615_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.20"
                     /molecular_weight="3029.5"
                     /monoisotopic_mass="3027.6"
                     /core_sequence="WFASMNLVCRLSGSPLNPPRQLAGLAQVG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MWTSHSARLGGLGGA"
                     /leader_location="[5867:5912](-)"
                     /alternative_weights="3047.5"
                     /alternative_weights="3065.6"
     CDS             5898..6032
                     /gene="allorf_3655601_3655735"
                     /locus_tag="allorf_3655601_3655735"
                     /protein_id="allorf_3655601_3655735"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTSPHRTLPRSMCKYCCSRRNNCSSFGGAVRQALLRHHLTCGDA"
     CDS_motif       5898..5981
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTSPHRTLPRSMCKYCCSRRNNCSSFGG"
                     /locus_tag="allorf_3655601_3655735_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       5982..6032
                     /prepeptide="core"
                     /locus_tag="allorf_3655601_3655735_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.30"
                     /molecular_weight="1743.0"
                     /monoisotopic_mass="1741.9"
                     /core_sequence="AVRQALLRHHLTCGDA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTSPHRTLPRSMCKYCCSRRNNCSSFGG"
                     /leader_location="[5897:5981](+)"
     gene            complement(6075..7415)
                     /locus_tag="JQS43_RS16340"
                     /old_locus_tag="JQS43_16275"
     CDS             complement(6075..7415)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024816.4"
                     /locus_tag="JQS43_RS16340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16275"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_239675260.1"
                     /transl_table=11
                     /translation="MSQPSQHEFASRLRGWRRARGLTQRELAGDALSVSYVSLLEAGRR
                     TPTPETVRSLAAALGCAPEELWAGAAGEVARPAALTLKFGQLALEAGKVAEAHALFESV
                     LAAAEVEPLVQVEARTGIAQALAAQGRLREAATAYEALVQEAIRSPRYLSSLSVVIRWC
                     RCLYELGELSRVVEVGTGAMRELDRLDAWQSETAIRLLATVAAAHFELGEVTQAERLLR
                     EGLRRAEELQSPPARATVLWNASHLASEDGRHREALELAEEALTYFRRSGQQRQVGRLL
                     SQYGLLLLRQEPPRVDEAQQLLEEGLHLLHQVGHGYDRGYLLTELARAHLLKGEPQAAS
                     ELADRALAELGPEAALERARADTVLAAALAAAGEWERAVTGFDRAAGALRQLGASRQAA
                     RAWVELGNLLDQAGDSARAVRAFREAAAAVNLVPTAGSAEPLSSRPG"
     misc_feature    7435..7450
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.27"
                     /tool="antismash"
     CDS             7463..7633
                     /gene="allorf_3657166_3657336"
                     /locus_tag="allorf_3657166_3657336"
                     /protein_id="allorf_3657166_3657336"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MQGETMMKFSSLTAAALLTLSLAIAPVIAGGVAISAATPGFGAEN
                     LSMGGATCCVD"
     CDS_motif       7463..7555
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MQGETMMKFSSLTAAALLTLSLAIAPVIAGG"
                     /locus_tag="allorf_3657166_3657336_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       7556..7633
                     /prepeptide="core"
                     /locus_tag="allorf_3657166_3657336_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.10"
                     /molecular_weight="2270.5"
                     /monoisotopic_mass="2269.0"
                     /core_sequence="VAISAATPGFGAENLSMGGATCCVD"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQGETMMKFSSLTAAALLTLSLAIAPVIAGG"
                     /leader_location="[7462:7555](+)"
                     /alternative_weights="2288.6"
                     /alternative_weights="2306.6"
     gene            7766..8614
                     /locus_tag="JQS43_RS16345"
                     /old_locus_tag="JQS43_16280"
     CDS             7766..8614
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="JQS43_RS16345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16280"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_239675261.1"
                     /transl_table=11
                     /translation="MPTVGITVLGPVQAWRDDQELPLGPPQQRSVLALLAVVGGQPITT
                     REIVEALWDSQPPRSAVNVVQTYLKRLRRILEPERPPRSASTLLPARHGGYALRAEPEA
                     VDLWRFRGLLGRARELHRIGDHRRVTTLLADALRQWHGPPGADLPALAQHHRVRAVVEE
                     YGAVVRWYAQASLVTGAPGEAVPVVAQAATGRPFDEPLHAQLIRLYHAAGQRSEAVRVF
                     QSCRRRLHDELGLDPGPELTGAFGELLRDQRPWSRAVPPELKPAPTTVRTGRPPLGRTG
                     P"
     gene            complement(8553..9974)
                     /locus_tag="JQS43_RS16350"
                     /old_locus_tag="JQS43_16285"
     CDS             complement(8553..9974)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013714.4"
                     /locus_tag="JQS43_RS16350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16285"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_239675262.1"
                     /transl_table=11
                     /translation="MEISTTAVTALAQRMRGDVVLPDAPEFPRLRKPFACGLGEVTPQA
                     VVRCAGVADVAEAVAFARAQRLPFALRSGGHSFADLSTSDGLVIDLAGLRSIEVGPETV
                     TVGPGVRLGELADRLAEVGRVVAVGWNPTVAVGGAVLGGGYGMLGRYFGLGCDQLLAAQ
                     VVLADGRQVTVDEHREPELFWALRGAGWAGFGAVTSLTLRTHPAPRVSTFVHCWPWEQA
                     AAVIDAWQHWAPVAPEEVNGELVLQSATPTGSGPRLVLFGAVVGGANDARPLVEEFLAE
                     VDLSAELGELAELSPVVAARRHTYAGMPVSTVAQPGPPAGQRPWLRAVKSDFFDAPMPA
                     EVIDALLAAFDPEPPAGQYREVELVPWGGAYARVAPAETAFVHRRAQFLIGHHGTALPH
                     LDDVARKAATDWVQQSWRAVRPAASGAVYPNYPDAELPEWASAYFGVNLPRLRQVKARY
                     DPAEVFRFGQSLAPA"
     misc_feature    complement(9417..9419)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..13042)
                     /locus_tag="JQS43_RS16355"
                     /old_locus_tag="JQS43_16290"
     CDS             complement(10001..13042)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018586211.1"
                     /locus_tag="JQS43_RS16355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16290"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_338037121.1"
                     /sec_met_domain="DUF4135 (E-value: 6.7e-78, bitscore:
                     260.7, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.1e-33, bitscore:
                     113.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAGISEVDASVTMDDADTPESPSRRTADIDRMLDAVVGPARSRL
                     AVELRSVPGLSTADGESLLASATLSLRDVGWRRVSRVLLLELHAARLAGRLTAADEAGR
                     WAEWVETVHRPDFWETLTEHYPPLLTRLRTVIDHRRAAALRLARRFARDRAMLSALAGH
                     ELGALQGIRFGAGDSHCGGETVAALHCESGKMLYKPRSLAVDAVLGRVLPALLPASAAP
                     HPIRVPRVLERSDRDGTYGWCDYVAHRYCADQGELATFYRNLGHWLAVMRLLGGSDLHA
                     ENVIAAGPVPVVVDCETLFTPHFPTRPSGYGAATDLAADLLNDSVMRTGLLPGRGGGLG
                     FRGIDPSAAGALPGQQATVSVPVIVDEGTDRARVGSADLPPPPTVNHPSPEPELGRHWP
                     QVVAGFAELTEHLHRLDQRGELAPRLAEFADCPTRVVLRDTIVYSELGRMLWHPSSLHR
                     PDRAAERAADLLARHADRRPGAPSDRAVIEAEVAALQEGDVPIFTTTPGRGELTGPGGT
                     RCGEPLDLVDDAVRRWRALDPATDQRVVQAALVGAYLNDGWLPPPQRLPVTGPRLDDLD
                     RQRREQAAAIMRDLVAYAITGPDETATWVAPVLNATGWSVQPLPADLYGGVAGVAVLLA
                     AYQREVAAGRAEEVAGAAELLPATLATLRAAEAAHAADLADARERGVAVRPEACGGYIG
                     LGSRIWSWLLLWQLGAVPGDQALAHATALAAELPAAVAADESHDLLLGAAGSIVPLLRL
                     AEASGEARWQETAVQIGHRLAAHAEPANEGHGGLRWLTPLFPAGVGGLSHGSTGIGWAL
                     ARLAVATAEPSFAGLAEEAFDFESSLYDPALGGWRDLRSPEPTTAAAWCHGAVGIGIAA
                     ADLRHRAQPERWREVLAQAAAVAWPGGVGWNHTLCHGDFGAWELFEHAWAAKVGSTLPA
                     REEVLAALLGSLAEHGAVSGLARDVFAPGLLPGQGGIVYQLLRMHPEAELPSVSLPDPG
                     PPPAGPLPSRQDDPATIPGSGSTG"
     gene            complement(13047..13271)
                     /locus_tag="JQS43_RS16360"
                     /old_locus_tag="JQS43_16295"
     CDS             complement(13047..13271)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040361.3"
                     /locus_tag="JQS43_RS16360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16295"
                     /product="DUF6229 family protein"
                     /protein_id="WP_239675263.1"
                     /transl_table=11
                     /translation="MPTLTIEQVDEIIDGWRNGEEQDGLENPAGPLFSSSGYAESEITL
                     TGTGYPGLSCGTGCSGSYDPATGMHYFCC"
     gene            complement(13426..15438)
                     /locus_tag="JQS43_RS16365"
                     /old_locus_tag="JQS43_16300"
     CDS             complement(13426..15438)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072454.1"
                     /locus_tag="JQS43_RS16365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16300"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_239675264.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.8e-22, bitscore:
                     77.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 7.4e-22, bitscore:
                     75.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 9e-31, bitscore:
                     105.3, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTQRTPETEAPKPAAGQGAGAAGASGPAQVSEAQARAVAESAR
                     ETTWRRPSFGKELFSGRLRLDLLHPWPTEDPAAAERYETFAGRLHEFLTTQVDGAQIER
                     DAQIPDQVFQGLAELGAFGMKIDEKYGGVGLSHLHYARALTLVGSANPAVGALLSAHQS
                     IGVPQPLKLFGTDEQRQTFLPRLAAGEVSAFLLTEPDVGSDPARLSTTAQPLPDGSGYL
                     LNGVKLWATNGTVATLLVVMAQVPPGEGNRGGISAFVVEGDAAGITVERRNAFMGLRGL
                     ENSVTRFHDVFVPKENLIGGEGQGLRIALTTLNTGRLSLPAHCVGAGKYSLAVARQWAQ
                     ERVQWGRPVAEHEAIGKKLAFIAASTYGMSAMLDLSCLLADDDHNDIRIEAALVKLYSS
                     ELAWQVGDELVQVRGGRGYETADSLAARGERPIATEQLLRDLRINRIFEGSTEIMHLLI
                     AREAVDVHLSVAGDLIDPKAGLGRKARAAGRAALFYARWLPGLLVGRGQLPGGYAEFGP
                     LARHLRWAERRSRRLARATFRGMARWQGRLERKQAFLARLVEIGAELYAVTAACVRARA
                     ERETRPESTALADTFCWQARRRTDAHFAALWRNTDASDRELARAVTEGRFEFLEAGILP
                     PAGDGAWVAGWEPGEAVVDDLRRRPLPAAADRASD"
     gene            complement(15531..18296)
                     /locus_tag="JQS43_RS16370"
                     /old_locus_tag="JQS43_16305"
     CDS             complement(15531..18296)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014444448.1"
                     /locus_tag="JQS43_RS16370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16305"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_239675265.1"
                     /transl_table=11
                     /translation="MRTSRAESPLMIGRDQELRRLRELAAVGASRVALLAGEPGIGKTR
                     LVQELLGGLPAATQVLLGHAEPESLARPYEVLLDALGAGPGAFPADDPELLVVTDQAAA
                     PVERLHAGLAVVERLLGDVPAVIVFEDLHWIDSESAALFERLADRDAPQLLVGTYRPDE
                     ITNRHPLAGLLARLERRHAVTHLRLSGLHQADTAALLASVAGRPVPHRSAAVLYDRTGG
                     NPFFLEELLRGCEGGDPARLGEQPLPWSLAEVLRRQVDELPPVGRRVAEAAAVLGHRVP
                     FDLFTAVTGTDESALVEALRELVERGLLVESGPDEFAFRHALVREALTSRMLGRERRRL
                     HETALEALLASGDPDPALVAHHAHGAGRYQELVDAARRGAPRYLEMGSAYQALQLAELG
                     LAEAGDDLALLAAATRSAWLAGLGEEAVEYARQWRRLATAPAERVDALTVALRLAWEAD
                     EVAEMVELTEQLAQLLPDLPAGPERARALTALAESSMLRGSTEAAVAWADAALELAASF
                     ELPRVRLAASVEKGCALMMQPHTRRRSRELLTAVAAESEHRREWTLAARACYALLQLGP
                     DPAAGDEQAALTGQAGILARMGVAAERANFESLLDTAFFQARAQVAIREGDLPAAIAAL
                     QEGRSRDRGYQVRGRRAHDYAVFLAGLYLEAGELDRVAELAAPLATSAARDRPALPGID
                     FHLACRRGDLAAAERYLDELLALRGRGVTFWGQLAHDLVSAGLAVGVALPRLRQLVGGG
                     DSQEDQRRLMTLVEAQLAEAAGEPATALAGFRAVAELPTGPPPVRGVAHTGAARCLLVL
                     GEKEAALGHAEAATTALARWGGWRVAQLAQLRAQLGMMPSAGPAAPTGPAALTAREREV
                     AVLVADGLTNAELARRLYISPRTAAVHVSHILRKLEVGSRTEVAAVLRPG"
     gene            complement(18263..18487)
                     /locus_tag="JQS43_RS16375"
                     /old_locus_tag="JQS43_16310"
     CDS             complement(18263..18487)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS16375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_16310"
                     /product="hypothetical protein"
                     /protein_id="WP_239675266.1"
                     /transl_table=11
                     /translation="MFTHPEMIFMMATEARHGIVHEVEDHRARRRHRRAGLGTRLRARL
                     RAGGRRATAQSGSGSSLAACVPAGPRARS"
     CDS_motif       complement(18296..18487)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MFTHPEMIFMMATEARHGIVHEVEDHRARRRHRRAGLGTRLRARLRAGGRRATAQSGSG
                     SSLAA"
                     /locus_tag="JQS43_RS16375_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(18263..18295)
                     /prepeptide="core"
                     /locus_tag="JQS43_RS16375_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.00"
                     /molecular_weight="995.2"
                     /monoisotopic_mass="994.5"
                     /core_sequence="CVPAGPRARS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MFTHPEMIFMMATEARHGIVHEVEDHRARRRHRRAGLGTRL
                     RARLRAGGRRATAQSGSGSSLAA"
                     /leader_location="[18295:18487](-)"
     gene            complement(18640..18978)
                     /locus_tag="JQS43_RS16380"
                     /old_locus_tag="JQS43_16315"
     CDS             complement(18640..18978)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024061.4"
                     /locus_tag="JQS43_RS16380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16315"
                     /product="RNHCP domain-containing protein"
                     /protein_id="WP_239675267.1"
                     /transl_table=11
                     /translation="MSFTRMVEDFVCEHCATRNVGNGYTNHCAHCLHSKHVDVDPGDRA
                     ADCQGLMVPVGVDTAGGGTSLLHRCDRCGAERRCKTAPEDDQDAIVAVATQPPPPIPRQ
                     RPRRRRHP"
     misc_feature    complement(19033..19047)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            complement(19080..20198)
                     /locus_tag="JQS43_RS16385"
                     /old_locus_tag="JQS43_16320"
     CDS             complement(19080..20198)
                     /EC_number="3.5.1.28"
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0009253 - peptidoglycan catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020520778.1"
                     /locus_tag="JQS43_RS16385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16320"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_239675268.1"
                     /transl_table=11
                     /translation="MHAPDDYCDGAPPGVGRRSLLRGAVLLGVGAAAGATALTTAAPAL
                     AQVSAPTIHNRAAWNARPPSSAVTIRNHRPNKIVIHHTATANQADTSLARAFSLSRGIQ
                     NHHMDTNGWIDAGQQFTISRGGHIMEARHQSLPTLQGGTSFPHGAHAGVQNSESIGIEN
                     EGTYTSVAPPAALYDALVHFCAYTCQQYQIPPSQIFGHRDFSATACPGNVFYGMLSQLR
                     NDVADAIDGGGNGGGGDFEAIVDSTSGNFTASGNWGTSSWSSQAYATPYHFAEPVLSSD
                     AAWFRANIPSAGTYQVDAWWPADPGYNNNTPFVVAASGGSETVHVNQRTNGGRWVSLGS
                     FSLSAGTYNVVGVSRWTTGSGYVLADAVRIRN"
     misc_feature    complement(20121..20123)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(20173..20186)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.3"
                     /tool="antismash"
     gene            complement(20278..22326)
                     /locus_tag="JQS43_RS16390"
                     /old_locus_tag="JQS43_16325"
     CDS             complement(20278..22326)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020520744.1"
                     /locus_tag="JQS43_RS16390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_16325"
                     /product="family 10 glycosylhydrolase"
                     /protein_id="WP_239675269.1"
                     /transl_table=11
                     /translation="MPSPLRASRAPALTGRIIAVAALLLVSGAVSVSSAGAVTTDPADV
                     ADPAAADAGSSQCATDPALPKRQLRAMWIASVANLDWPSSSGLSAAQQQAEYRAQLDLA
                     EEHQLNTVIVQVRPTADAFWPSPYEPWSHWLTGSQGSDPGYDPLEFMIDETHARGLEFH
                     AWFNPYRVATHDDLSQLHPEHPARQHDDWVFSYGGQLYYDPGVPAVREHVTAAMMHAVS
                     NYDLDGVHWDDYFYPYPSGSTPIPDQDTFAEYGGDFTDIDDWRRDNVDQLVAEMGAQIS
                     AEKSHVKFGVSPFGIWRNQSTDPLGSATNGLQSYDAIYADTRRWVVEEWVDYVVPQIYW
                     PIGFAAADYSVLVPWWSDVVAGTQVQLFIGQATYRAGAAGEDPAWQQPSVLSDLLAFNR
                     DHPEVLGDVHFSAKDVQADRIGAMSQLVADHYARPALVPVAPHLGGAAPAAPSGLTATT
                     AGGDIEVSWQAVSGASSYAVYRLDGAASGVDPCDFADARHLLGTTTDTSFADATAAGAT
                     YTYHVAALDRLHHESDPSAGVVVDGENGGGDFQTIIDSTSDRFHASSDWGSSSYSPQAY
                     GDTYRFAEPVAASDPAWYQIDVPGTGDYRVEVWYPADPGYHGATPYLVSTVDGLQTVPV
                     DQRIDGGQWVELGTFTLAEGDYDVIGVSRWANGSGYVIADAVRITQV"
     misc_feature    complement(22357..22372)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    22402..22417
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.81"
                     /tool="antismash"
     misc_feature    22437..22451
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.67"
                     /tool="antismash"
ORIGIN
        1 tgcttggcct cgaacgcctc ctccagctgg tcggagcgga accgccggtg gcacgactgg
       61 cactcggtga gcggatcgac gaaggcgtcg acatggccgg aggcgaccca cacgtcccgg
      121 ttcagcacca cggcggagtc caggccgacc acatcatcgc gctgctggac catcgtgctc
      181 caccactgcc ggcggacgtt ttccttcagc tccacgccga gcggaccgta gtcccaggcg
      241 gatcgactcc ccccgtaaat ctcgctggag gggtacacga agccccgccg cttggcgagg
      301 ccgacgacgg cgtcgatccg atctgcagcc acactggctc cttcagtcac aggcggccgg
      361 ctggctgccg gcgcggcgtc aagattgggc accttgaagt cagcccctca aggtttggta
      421 cgtccagcgt acggccggcg ccggggcggt cgcagcctgg ttttccggcg cgggcgtccg
      481 cgtcgtgacc tgagggctgc cctactccgg cgtgaaggtg ccgcacactt cgaactcccc
      541 ggtctccacg ttctgctcca ccgggatgtc gagcaccgta tcagtcccgt cgacgtacgc
      601 cacgtcgacc ggcacccgca tgtcaccggt gccgaagacg tcgtcgccgg gctcaatctc
      661 caggtcaccg acctggtagt cgtcgatggc cggcagggcc tgcatccggc tgctgaactg
      721 gctcagcggc tccgtgttgc ggtcggccgc acaccgctgg tcgtaggcgg tctcccaatc
      781 ctggtcggcg agcgcaccga cgaactcgcc caccggccgc tgcgcctgct cgttgatcac
      841 ctgctgacct agcaccagca gcccaccgcc ggcgaccgcc ccgaccccgc agcacgccgc
      901 gaccagcgcc cccgccacgc ccagaccaac gccgatccgc aatcgtcgac cctcgatcgg
      961 agcggcgacg aacggtggct gaacgccagg cccaggcggc ggaccaggcc ggtcaggcgg
     1021 cgtggtcatg ctcggcccga tcactgtcgt agcgggtcac cgggccctcg ggggcggcct
     1081 cggcgagcac ttcaaacccg gccgggtccg gctcggcgct ggcgagcagc ggggtcgcgt
     1141 acatcttgac gtcgaagtga ccgagcgccc gccggtatgc cccgaccgag gcccaccggg
     1201 tgagcaggca ccaatgagct ggatcgtcga gcgcccgcgt gagttcgccg ccctggtagc
     1261 cggggcgagc ggcgaagacc gccagcgcct gctgcgcttg ggcggtgaac tcggcggtac
     1321 gctcaggcgg taccacaaac cggttgagcg cgagcaccgc gagcctccct actgcgactg
     1381 ccgggatgtg tcgaccccag tctggaacga gcctaacgaa ccgtggcgag tgaagcagaa
     1441 tgacaccgaa ccctgacgac gaccggccgg cgacctccga ccttctggcc cggctcaatc
     1501 gagccaatcc gacgctagtg gtcttcggcg cgctggcgat ctttctcggg atcctcttcc
     1561 tccccgacct gtggggggcg ctgctggtgc tggtgctggt cggcgcgctg ggctggttgc
     1621 tgagccggac ctggccggtg ctgaccccgg cggcccgggg gatccgactg gcggtgatcg
     1681 cgctactgct gctggtagcg ctgctcaagc tcaccacctg acccggcagc ccgggccgac
     1741 ccatgcagag ttggcaatga ttgtcgttaa ccggcagggt ggtcctcatg ctgagacgat
     1801 ccctggccta cgccagcacc gggctactgc tgggcgccgc gaccgcctgt gccgccgacg
     1861 ccgaggaagg cagtgacgaa gctgcggtgg acgtggtggc ggccttctac ccactggagt
     1921 tcgtcgctga ccgggtcggc ggcgaacggg tctcggtgac cgggctggct ccgcccggcg
     1981 tcgaggcgca cgacctggag ctgacaccgt cccaggtcgc cgagatcagc cagtccgacc
     2041 tggtggtctt cctcaccgac ttccagccgg cggtcgacgc tgcggtggcc gagcacgccg
     2101 acgaccgcgg cttcgacgtc gccgaggtgg tgccgctgct ggacaatccg gacggccacg
     2161 accacgacca cggacacagc cacgatgacg aggatgcccg cgaagacgac cacgatcatg
     2221 accatgatca cgaccatgat gatgatcatg accacgatga cgacgaccac gggcacgacg
     2281 acgaccacgg ccacgaggac gacgaagacg ggcacgagga ggacgacgag cacggcgacg
     2341 acgaccacgg acatgaccac ggcgaccagg acccgcacgt gtggcaggac ccggaccggc
     2401 tagccaccat cgccgacgaa ctcgccgtgg agctgggcgc actcgacgcc gactacgccg
     2461 acgagtacgc cgccaacgcc gcagcgctgc gggaggagct ggacacgctc gaccaggagt
     2521 acgccgacgg gttggcccag tgcgaacggc gtgagatcgt ggtcagccac gccgccttcg
     2581 gctacctgtc ggaccggtat gatctccggc agatcgccat cagcgggctc tctcccgagg
     2641 acgagcccag cccgcaacgg ctcgcggagg tcatccggga ggcggaggcg cacggtgcca
     2701 ccaccatctt cttcgaggtg ctggtgagcc cggcggtagc ggaggtgatc gccaccgagg
     2761 tcggtgccga gaccgcggtg ctggacccga tcgaagggct cgcgcccggc agcgaggagg
     2821 attacttttc ccttatgcgc gccaacctcg acacactccg gggagcactg gactgcacgt
     2881 gagcaccccg gtcctggaac tcgcgcacgg ggtggtcggc taccacggcc gccccgtgct
     2941 gccgggcgtc tccctgcggg tcaacgccgg tgaggtggtg gcgatcctgg gcgccaacgg
     3001 ctccggcaag tccaccctga tcaaggcggc gctgggcctg ctgcccctga ccgccggctc
     3061 agcccggctc ttcgacaccc cgctggggcg gttccggcag cgctaccggc tcggctacgt
     3121 gccgcagcgc gccggggccg gcagcggcgt gccggccacc gtcaccgagt tggtcagcgc
     3181 gggccggctg ccgcgccgcc ggctgccgtg gccgcgctgg tcggccgacc gggcggcggt
     3241 gacgcacgcg atcgccgtgg tcgggctgac cgagaagcgg cgggagccgg tgggcacgct
     3301 ctccggcggc cagcagcagc gcgccctgat cgcccgggcc ctggcctgcg aaccagagct
     3361 gctggtgctc gacgaaccga ccgccggcgt ggacgcggcc agccaggtcg ccttcgccgg
     3421 cgcgctgcgg cacttcgtcg acgccggcgg gacggtggtg ctggtcgccc acgagctggg
     3481 cccactagcg ccgctgatca cccggaccgt ggtgttgcac gagggtcggg tggtgcagga
     3541 caccgccggg gcggccgtcg ctaccgactc gaccaccgcc tcggaccccg gcacgggcca
     3601 ccacgacgag ccgccggcgc cctccccggt cgggtggcag ccctcgctca tccaggagct
     3661 gccccggtga gcatcttctc gctgccgttc atgcagtacg ccctgatcgg cgcgctgatc
     3721 accgggctgg tcgcgccggc gctcggcacc tacctggtgc agcgccggct ggcattgatc
     3781 ggcgacggga tcggccacgt cgcgttgacc ggtgtcgcgg tcgggctgct gttggcgcag
     3841 tccccggtga tcaccgccat ggtggtggcc gccgccggcg cgatcgccat cgagctggtc
     3901 cgcgagcgcg gaaagacctc cggcgatgtg gcgctagcgg tcctgttcta cggcggcatc
     3961 gccggcggtg tgttcctggt caacctctcg gccagccaca ccaacgccaa cctgatggcg
     4021 tacctgttcg gttcaccgct caccacctcc cctgccgacc tgcggattat ggcgatactc
     4081 ggcggcgcgg tgctgctggt gacgctgggg ctgcggccgt ggctgttcgc gatctgccac
     4141 gacgaggagc acgcccgggt cagcgggttg ccggtgcggg cactgaacct gctgctggcg
     4201 gtgaccaccg cggtgacgat cacggtggcg atgcgggcgg tcgggctgct gctggtcagc
     4261 gccctgatgg tggtcccggt ggcgaccgcg cagctggtcg cccgcggttt ccgggccacc
     4321 cagctgttgg cgatggcgat cggagtggcc gccgcggcgg ccggcatctg gttcgccggg
     4381 gtctacgaca ccgcgcccgg cgccaccatc gtgctgctgg cgatcgccgg gttcgcggtc
     4441 gtcaccgtgg tcacggccgg gtggcggtgg ctccgccggg ggcgcgaccg gcgacccggt
     4501 gagccggtag tgccgccgcc cgaggtaacg ttggcccgct agaggctacg gttaggacgt
     4561 gggcggaaac gaagcgtacg aggcggccgg tgaacttctg cgtgcgctcg ccgcaccgat
     4621 ccgaatcgcc atcgtcaccg agttggccga cggccaacgc tgtgtgcacg agctggtcga
     4681 cgcactcggg gtggcgcagc cgttggtgag ccaacacctg cgggtgctcc ggggggccgg
     4741 ggtggtcaaa ggcgcccgcc gcgggcggga gatcgcgtac acactggtcg acgagcacat
     4801 cgcccacatc gtcgccgacg ccatcagcca cgctggtgag caacgtcccg gcgaggtccc
     4861 cactgtcgag atggcaaggg aggttagggc gccatgacgg cgaccaccga caccccaggc
     4921 gtacgccaca cccgccagcg cgctgcggtc agcactctgc tcaacgaggt cgagggtttc
     4981 cactccgctc aggagctgca cgcgatgctg cgagaacggg gcgagcgggt aggcctgacc
     5041 accgtctacc gcaccctgca ggggttggct gacggcggcg aggtggacgt catgcgcccg
     5101 cccggcggtg agcacctcta ccgccggtgc agcgagggcc atcaccacca tctggtgtgc
     5161 cgcgcctgcg gccgtaccgt cgaggtcgaa gggcccgcgg tcgagacctg ggcgagcaag
     5221 gtcgcggcga gcaacgggtt caccgaggtg agccacacac tggagatctt cggcacctgc
     5281 ccggcctgcg ccggctagcg gcggcgccgt cgttttcgtg gcgccgtcgt tttcgtggcg
     5341 cacacctggc gagacgtgat catcttcccc gccgcagcct agggtggtgc tgcgggagtg
     5401 tttgctctgc gtacgtaacg ccatcggccg ggcggtcggg ctgcaagatc ggcgggcaga
     5461 tcgtctcacc cgacttggtg ggtcgagtgg cgcctggttt gccaatatga acctggtttg
     5521 tcgccgtagt ggatcaccac tcaaccgacc aagcggccga cggtgtgaca gccggcgaca
     5581 gggaggggcc ccttcctgat cgccgcttga tgaccttgag cgtagctgcc gaggacccgc
     5641 gccaagccgc tgcgccaaag ccgctgcgcc cagagcctac gagagctgcc ggcacagacg
     5701 gagcagcggc gagggcgcca cggtaggaag gcgcccggcg ccgcctgcgg gtcgccgcgt
     5761 gacctagccc tcctgagcta gcccacctga gctagcccgg cgagctgcct tggtgggttg
     5821 agtggtgatc cactaaggcg acaaaccagg ttcatactgg caaaccaggc gccacccaac
     5881 ccaccaagcc gagcactgtg actagtccac accgaactct gccacgaagt atgtgcaaat
     5941 attgctgttc ccgccgcaac aactgctcaa gcttcggcgg cgcggtcagg caagcgctcc
     6001 tgcggcacca cctgacctgc ggggacgcat gatggtcagg cgcgttggac cggcggagag
     6061 ccccgcggag ctggtcagcc aggtcgggag ctgagcggct cggcggagcc cgcggtgggc
     6121 accagattca ccgcggcggc cgcctcccgg aacgcgcgca ccgcgcgggc gctgtcaccg
     6181 gcctggtcca gcaggtttcc gagctcgacc caggcccggg cggcctgccg ggaggcgccc
     6241 agttgccgga gcgccccggc ggcccggtcg aagccggtca ccgctcgctc ccactcgcca
     6301 gcggcggcca gcgcggcggc gagcaccgta tcggcgcggg cgcgctccag ggcagcctcc
     6361 gggcccaact cggccaacgc ccgatcggcc agctccgagg cggcctgcgg ctcgcccttc
     6421 agcaggtggg cgcgggccag ttcggtgagc aggtaacccc ggtcgtagcc gtggcccacc
     6481 tgatggagca ggtgcaggcc ttcttccagc agctgttggg cttcgtccac ccggggcggt
     6541 tcctgtcgca gtagcagcag cccgtactgg ctgagcagcc ggccgacctg ccgctgctgg
     6601 ccgctgcgcc gaaagtaggt gagcgcctcc tcggccagct ccaacgcttc ccgatgccgt
     6661 ccgtcctcac tggccaagtg gcttgcgttc cagagcaccg tcgcccgcgc cggtggtgat
     6721 tggagctctt cggcgcggcg caggccttcc cggagcagcc gctcggcctg ggtgacctcc
     6781 ccgagttcga agtgggcggc ggcgaccgtc gccagcaacc ggatcgccgt ctccgactgc
     6841 caggcgtcga gccggtcgag ttcacgcatc gccccggtgc ccacctccac cacccgggag
     6901 agctccccca gctcatacag gcaccggcac catcggatga ccacgctcaa cgacgagagg
     6961 taacggggcg accggatcgc ctcctgcacc aacgcctcat aggcggtggc ggcttcgcgt
     7021 agccgaccct gggccgccag cgcctgggcg atccccgtcc gggcctcgac ctgcaccagg
     7081 ggctccactt cggccgcggc gaggacgctc tcgaacagcg cgtgcgcctc ggcgaccttg
     7141 ccggcctcca gcgcgagctg gccaaacttg agggtgagcg cggccggccg ggcaacctca
     7201 ccggcagccc cggcccacag ctcttccggg gcgcagccaa gcgctgcggc gaggctgcgc
     7261 accgtctccg gggtgggggt gcggcggccc gcttcgagca gcgagacgta gctgaccgac
     7321 agcgcgtcgc cggccagctc ccgctgggtc agaccacgcg cccgccgcca acctcgaagc
     7381 cggctagcaa actcatgttg actcggttga ctcatagtaa tcccccgctc tacaatctac
     7441 actagaatac ccacgccgat ctatgcaagg ggagacaatg atgaaattct cgtccctgac
     7501 cgccgccgct ctgctcaccc tcagcttggc gatcgcgccg gtcattgctg gcggcgttgc
     7561 tatttcagcc gcaactcccg gtttcggtgc ggagaattta tcaatgggcg gagccacctg
     7621 ctgcgtagat tagtcgacac gcgacaatcg cccgattcac acactcctgt gaccactcgt
     7681 agcgagttct gttgacggag ttagtcaact agttgactgt tccggcacga cgctccgagc
     7741 tgcgtccaac cccgacagga ggatcatgcc caccgtcggc atcaccgtgc tcgggccggt
     7801 tcaggcctgg cgtgacgacc aggaactccc ccttggaccg ccgcagcaac gcagcgtcct
     7861 ggcgctactg gccgtggtcg gcggccagcc gatcaccacc cgcgagatcg tcgaagcgct
     7921 gtgggattcc cagccgccgc gcagcgccgt caacgtcgtc cagacatatc tgaaacggct
     7981 ccgccggatc ctggagcccg agcgaccccc acgcagcgcc agcactctgc tcccggcccg
     8041 ccacggtggt tacgcgctgc gggcggagcc cgaggcggtc gacctgtggc gcttccgagg
     8101 gttgctcggc cgcgcccggg agctacaccg catcggcgac caccgtcgcg tcaccacact
     8161 gctcgccgac gcgctgcggc agtggcacgg cccgcccggc gccgacctgc cggcgctcgc
     8221 ccagcaccat cgggtacgcg cggtcgtcga ggagtacggc gcggtggtgc gctggtacgc
     8281 ccaggccagc ctggtcaccg gcgcccccgg ggaagcggtg ccggtggtcg cccaagccgc
     8341 caccggacgg cccttcgacg aaccgctcca cgcccagctg atccggctct accacgccgc
     8401 tggccaacgc agtgaggcgg ttcgggtgtt tcagagctgc cgccgccgac tgcatgacga
     8461 actcggactc gaccccggcc cggagctcac cggcgccttc ggtgaactcc tccgtgacca
     8521 gcgcccctgg tcgcgcgctg tgcccccgga gctcaagccg gcgccaacga ctgtccgaac
     8581 cggaagacct ccgctgggtc gtaccgggcc ttgacctgcc ggagccgcgg caggtttaca
     8641 ccgaagtacg ccgacgccca ctccggcagc tcggcatcgg ggtagttcgg gtagaccgcc
     8701 ccgctcgccg ccggccgtac cgcccgccat gactgctgga cccaatcggt cgccgctttg
     8761 cgggcgacgt cgtcgaggtg cggcagcgcg gtgccgtggt gtccgatcag gaactgagcc
     8821 cggcggtgga cgaacgcggt ctccgctggc gccacccggg cgtaggcgcc gccccacggc
     8881 accagctcca cctcccggta ctgccccgcg ggcggctccg ggtcgaacgc cgccagcagc
     8941 gcgtcgatca cctcggccgg catcggcgcg tcgaagaagt ctgacttcac cgcccgcagc
     9001 caggggcgtt gcccggccgg cggacccggc tgggcgacag tcgacaccgg catcccggcg
     9061 taggtgtggc gccgggccgc caccaccggg gacagctcgg ccagctcccc cagctcggcc
     9121 gagagatcca cctccgctag gaactcctcc acgagcggcc gggcgtcgtt cgcgcctccc
     9181 accaccgctc cgaagagcac cagccgcggg ccgctgccgg tcggggtcgc cgactgcagc
     9241 accagctcgc cgttgacctc ctcgggtgcg accggcgccc agtgctgcca cgcgtcgatc
     9301 accgccgccg cctgctccca cggccagcag tggacgaagg tgctcacccg aggggccggg
     9361 tgggtgcgga gcgtcaacga ggtgactgcg ccgaacccgg cccaaccggc accgcgtaac
     9421 gcccagaaca gctccggctc acggtgttcg tccacggtga cctgtcggcc gtcggcgagc
     9481 accacctggg ctgcgagcag ctggtcgcac ccgaggccga agtagcggcc gagcatgccg
     9541 tagccgcccc cgagcaccgc accgccgacc gcgaccgtcg ggttccagcc gaccgccacc
     9601 acccggccca cctcggcgag tcgatcggcc agctccccga gccgtacccc gggcccgacc
     9661 gtcacggtct ccgggccgac ctcgatcgac cgcagccccg ccaggtcgat cacgagcccg
     9721 tcgctggtgc tgaggtcggc gaagctgtga ccaccactgc gcagcgcgaa cggcaaccgt
     9781 tgggcgcggg cgaaggctac cgcttcggcg acatcggcga cgcccgcgca gcggaccacc
     9841 gcctgcggtg tcacctcacc caacccgcac gcgaacggct tccgcagccg agggaactcc
     9901 ggtgcgtccg gcagcaccac gtcgccgcgc atccgctgcg ccagtgcagt taccgcggtg
     9961 gtgctgatct ccatcgtgat cctccagagt gcccgcggtc tcagccggtg ctgccgctgc
    10021 ccgggatcgt agcgggatcg tcctgtctgg agggaagcgg gcccgcgggt ggcggaccag
    10081 ggtcgggcag cgacaccgag ggtagctctg cctcgggatg catccgcagc agctggtaga
    10141 cgataccgcc ctggcccggc aacaggcccg gagcgaagac gtctctcgcc aacccgctga
    10201 cggcgccgtg ctcggccaga ctgcccagca gcgcagccag cacctcctcc cgggccggca
    10261 atgtcgaccc caccttcgcc gcccacgcgt gttcaaacag ctcccaggcg ccgaagtcgc
    10321 cgtgacacag ggtgtggttc cagccgactc cgcccggcca ggcgaccgcc gctgcctggg
    10381 cgagcacctc gcgccagcgc tccggctggg cgcggtgacg caggtcggcg gcggcgatgc
    10441 cgatcccgac cgcgccgtgg caccacgctg cggcggtggt cggctctgga gaacgcagat
    10501 cccgccagcc acccagcgcc gggtcgtaga gggacgattc aaagtcgaac gcttcctccg
    10561 ctaggccggc gaaggagggt tccgcggtag ccaccgccaa ccgggccaac gcccaaccga
    10621 tgccggtgct gccgtgggag agcccgccca cgcccgccgg gaagagcggc gtcagccagc
    10681 ggagaccacc gtggccctcg ttggcaggtt cggcgtgcgc cgccaaccgg tggccgatct
    10741 gcaccgccgt ctcctgccac cgcgcttcac cgctcgcctc cgccaaccgc agtagcggca
    10801 cgatcgagcc ggccgcgccg aggagcagat cgtgcgactc gtcggccgcc acggcggccg
    10861 gcaactcggc cgccagcgcg gtggcgtgcg ccagtgcctg gtcgcccggc accgccccta
    10921 gttgccacag cagcagccag ctccagatcc gcgaacctag tccgatgtat ccaccacaag
    10981 cctccggccg caccgccaca ccgcgctccc gcgcatccgc gaggtcggca gcgtgggcag
    11041 cctccgccgc ccgcagcgtc gccaacgtcg ccggcagcag ctccgccgcc ccggcgacct
    11101 cctcggcgcg ccccgccgcc acctcgcgct ggtaggcggc gagcagcacc gctaccccgg
    11161 cgacgccgcc gtagaggtca gccggcagcg gctgcaccga ccagccagtg gcgttgagca
    11221 ccggcgccac ccaggtggcg gtctcatccg gaccggtgat cgcgtacgcc accagatctc
    11281 tcatgatcgc ggcggcctgc tcgcggcgct ggcggtcaag gtcgtcaagg cgtgggccgg
    11341 taaccggcag ccgctgcggc ggcggcagcc aaccatcgtt caggtacgcg ccgaccagcg
    11401 ccgcctggac cacccgctga tcggtcgccg gatccagcgc acgccaccgc cgtacggcgt
    11461 cgtcgaccag gtcgagcggc tcgccgcacc gagtgccccc ggggccggtc agctcgccgc
    11521 ggccgggcgt cgtggtgaag atcgggacgt cgccctcctg cagcgctgcc acctccgcct
    11581 cgatcaccgc ccggtcgctc ggcgcacccg gccggcggtc ggcgtgccgg gccagcagat
    11641 cggcggcgcg ctcggcggcg cggtccggcc gatgcaacga actggggtgc cacagcatcc
    11701 ggcccagttc ggagtagacg atagtgtccc gcagcaccac ccgggtgggg cagtcggcga
    11761 actcggccag ccggggggcc agctctcctc gctgatccaa cctgtgcagg tgttcggtga
    11821 gctcggcgaa gcccgccacc acctgcggcc agtgccggcc cagctccggc tccgggctgg
    11881 gatggttgac ggtcggcggg ggcggcaggt cggcgctgcc gactcgggcc cggtcggtgc
    11941 cttcgtccac gatcaccggc accgagaccg tcgcctgctg gccaggcagg gctccggcgg
    12001 ccgacgggtc gatgccccgg aaccccagcc caccgccgcg ccccggcagc agcccggtgc
    12061 gcatcacgga gtcgttgagc aggtcagcgg cgaggtcggt ggcggcgccg tacccgctgg
    12121 gccgggtcgg gaagtgcggc gtaaacagcg tctcgcagtc caccaccacc ggcaccgggc
    12181 cggccgcgat gacgttctcc gcgtgcagat cgctgccgcc gagcaaccgc atcaccgcca
    12241 gccagtggcc gaggttgcgg tagaaggtcg ccaactcgcc ctggtcggcg cagtagcggt
    12301 gggccacata gtcgcaccaa ccgtaggtgc cgtcacggtc ggaccgttca agcacccgcg
    12361 gcacccggat cgggtgcggt gcggccgacg ccggcagcag cgccggcaac acccgaccca
    12421 gcactgcgtc caccgccagc gaccgtggtt tgtagagcat cttcccggac tcacagtgca
    12481 gcgccgcgac cgtctcgccg ccgcagtggc tgtcgccggc gccgaaccgg atcccctgca
    12541 gggcgccgag ttcgtgcccg gccagcgccg acagcatcgc ccggtcccgg gcgaaccgac
    12601 gagccagccg cagggcggcc gcccgacgat ggtcgatgac ggtacgcagc cgggtcagca
    12661 acggtggata gtgctcggtg agcgtctccc agaaatcggg ccggtgcaca gtctcgaccc
    12721 actcggccca gcggcccgct tcatcggccg cggtgagccg gcccgccagc cgcgccgcgt
    12781 gcagctccag cagcagcacc cggctgaccc gccgccagcc gacgtcccgc agcgagagcg
    12841 tggcgctggc gagcagcgac tcgccgtcgg ccgttgacag gccgggcacc gaccggagct
    12901 caacggcgag gcgggagcgc gccggcccca ccactgcgtc gagcatccgg tcgatgtccg
    12961 cggtccgccg ggacgggctc tccggggtgt cagcgtcgtc catggtgacc gaggcgtcga
    13021 cctcggagat cccagcagtc atcggctcag cagcagaagt agtgcatgcc ggtggccggg
    13081 tcgtaggacc cgctgcagcc ggtaccgcag ctcaggcccg ggtagccggt gcccgtgagc
    13141 gtaatctccg attccgcgta cccgctgctg ctgaagagcg ggccggcggg gttctccagc
    13201 ccgtcctgct cctcgccgtt gcgccagccg tcgatgatct cgtcgacctg ttcgatggtg
    13261 agagtcggca tccacgtgct cccttctggg tgtctgggac acgtacgaga ttgccgactc
    13321 gcattggaca actgctggat gacgactgga caccgggccc gacccggcca gtccgactgg
    13381 ctggccgggt cggatgggct gcccggtcgg gtaagccgtg ccccctcagt cgctggctcg
    13441 gtcagccgcc gcgggcaacg gccggcggcg aagatcgtcg accaccgcct cgccgggttc
    13501 ccagcccgcc acccaggcgc catccccggc tggcggaagg atgccggcct ccaggaactc
    13561 gaaccggcct tcggtgaccg cccgggccag ctcccggtcg gacgcgtcgg tgttgcgcca
    13621 cagcgcggcg aagtgggcat cggtgcggcg gcgcgcctgc cagcagaacg tgtccgccag
    13681 cgccgtcgac tccggtcggg tctcccgctc ggcgcgggcc cggacacagg cggcggtgac
    13741 cgcatacagc tcggcaccga tctccaccag ccgggccagg aacgcctgct tgcgctccag
    13801 ccggccctgc cagcgcgcca tcccccggaa ggtggcccgg gccagccgcc ggctgcggcg
    13861 ctccgcccag cgcagatgcc gggcgagcgg accgaactcg gcgtacccgc cggggagctg
    13921 cccccggccc accagcagcc ccggcagcca acgggcgtag aacagcgctg cccgtccggc
    13981 tgcccgggcc ttccgcccca gcccggcctt gggatcgatc aggtccccgg cgaccgagag
    14041 gtgcacgtcg accgcctccc gggcgatcaa cagatgcatg atctcggtgg aaccttcaaa
    14101 gatgcggttg atccgcagat cccgcagcag ctgctcggtc gcgatcggcc gttcgccgcg
    14161 ggcagccagc gaatctgcgg tctcgtagcc ccgcccaccg cgtacctgca ccagttcgtc
    14221 gccgacctgc caggccagct cggaggagta gagcttgacc agggccgctt cgatccggat
    14281 gtcgttgtgg tcatcgtcgg cgagtaggca gctcaggtcg agcatcgccg acatgccgta
    14341 ggtgctggcc gcgatgaagg cgagcttctt gccgatcgcc tcgtgctcgg ccaccggccg
    14401 tccccactgc acccgttctt gcgcccactg ccgggccacc gccaggctgt acttgccggc
    14461 gcccacacag tgcgccggta gcgagagccg gccggtgttg agggtggtca gggcgatccg
    14521 taggccctgc ccctccccac cgatcaggtt ttctttcggg acgaagacat cgtggaaccg
    14581 ggtgacgctg ttttccaggc cgcgcaggcc catgaaggcg ttgcgccgct ccaccgtgat
    14641 gcccgccgca tcgccctcga ccacgaacgc ggagataccg ccccggttac cctcaccggg
    14701 cggcacctgc gccatcacca ccagcagggt cgccacggtg ccgttggtgg cccacagctt
    14761 caccccgttt agcagatagc cggagccgtc gggcagaggc tgggcggtgg tggagagccg
    14821 cgccgggtcg gagccgacgt ccggctcggt gagcaggaac gctgacacct cccccgcggc
    14881 cagccggggt aggaaggtct gccgctgctc gtcggtgccg aacagtttta gcggctgcgg
    14941 caccccgatc gactggtggg cgctcagcag cgccccgacc gccgggttcg ccgaccccac
    15001 cagggtgagc gcgcgggcgt agtgcaggtg actcaaaccc acgccgccgt acttctcgtc
    15061 gatcttcatc ccgaaggcgc cgagctcggc gagcccttgg aacacctgat caggaatctg
    15121 ggcatcccgc tcgatctggg cgccatccac ctgggtggtg aggaattcgt gtagtcggcc
    15181 ggcgaaggtc tcataccgct cggcggcggc cgggtcctcg gtcggccacg ggtggagcag
    15241 gtcgagccgg agccgaccgc tgaacagttc cttgccgaag ctcggtcgcc gccaggtggt
    15301 ttcccgcgcg gactccgcga ctgctctggc ttgcgcctcg ctgacctgtg ccggaccact
    15361 cgccccggcg gcgccagcgc cctggccggc cgccggcttc ggggcctcgg tctctggtgt
    15421 gcgctgtgtc gtcgtcacga tgcacccctt agtcgcctcg tggctctccc acccaggtta
    15481 ctagcgagta agccagcatg cagcacactt gcgggcgatc ggtcagcccc tcagcctggc
    15541 cgcaacaccg ccgcgacctc ggtacgcgac cccacctcaa gcttgcgcag gatgtgcgag
    15601 acgtgcaccg cggcggtgcg cggcgagatg tagagccggc gtgccagctc ggcgttggtc
    15661 agcccgtccg cgaccagcac cgccacctcc cgctcccggg cggtcaacgc ggccgggccg
    15721 gtcggcgccg ccggccccgc cgacggcatc atccccaact gcgcccggag ctgcgccaac
    15781 tgggccaccc gccaaccacc ccaccgggcc aacgcggtgg tcgccgcctc ggcgtgcccg
    15841 agcgcggcct ccttctcgcc cagcacgagc aggcagcggg cggcgccggt gtgcgccaca
    15901 ccacgcaccg gcggcggccc cgtcggcaac tcggctaccg cccggaaccc ggccagcgcc
    15961 gtcgccggtt cccccgccgc ctccgcaagc tgagcctcga ccagggtcat caaccgacgc
    16021 tgatcctcct ggctatcacc gccgccgacc agctgacgca gccgcggcag cgccactccc
    16081 accgccaacc cggcggagac cagatcgtgc gccagctgcc cccagaacgt gacgccgcgc
    16141 ccccgcaacg ccaatagctc gtccaggtag cgctccgccg ccgccaggtc gccgcggcga
    16201 caggcgagat ggaagtcgat acccggcaac gcgggccggt cccgggccgc actggtcgcc
    16261 aacggcgcgg ccagctccgc cacccggtcc agctcacccg cctccagata gaggccggcc
    16321 agaaacaccg cataatcgtg cgcccgccgc ccccgtacct ggtagccacg gtcgcgcgac
    16381 cgcccttcct gcaacgccgc gatcgctgcc ggcagatctc cctcccggat cgccacctgc
    16441 gccctagcct gaaagaaagc ggtgtccaga agcgattcaa agttggcgcg ctcggcggcc
    16501 acccccatcc gggccaggat cccggcctgc ccggtcaggg ccgcctgttc gtcgccggcc
    16561 gccgggtccg gccccagttg cagcagcgca taacaggccc gggccgccag cgtccactcc
    16621 cggcggtgct cggactccgc ggcaacggcg gtcaacagct cgcgcgaacg gcgccgcgta
    16681 tgcggctgca tcatcagcgc acagcccttc tcgaccgagg ccgccaaccg gaccctcggc
    16741 aactcgaagg acgccgccaa ctccagcgcc gcgtccgccc acgccaccgc ggcctcggtc
    16801 gagccgcgca acatcgacga ctccgccaac gcggtcaggg cgcgggctcg ctccggcccc
    16861 gccggaaggt ccggcaacaa ctgggcgagc tgctcggtga gctcgaccat ctccgcgacc
    16921 tcgtcggcct cccacgccag ccggagagcc accgtaagtg cgtccacccg ctccgccggc
    16981 gcggtcgcca gccggcgcca ctgccgggca tactcgacgg cctcctcacc caggccggcc
    17041 aaccaggccg agcgggtcgc cgccgccagc agtgccagat catcgccggc ctcggccagc
    17101 cccagctccg ccagctgcag cgcctggtag gccgacccca tctccagata gcgcggggcg
    17161 ccccggcggg ccgcgtcgac cagctcctgg tagcggccgg cgccgtgggc atggtgcgcc
    17221 accagcgccg ggtccgggtc gccgctagcc agcaacgcct ccagcgcggt ctcgtgcaac
    17281 cgccgccgct cccggccgag catccggctg gtcaacgcct ccctgaccag cgcatgccgg
    17341 aaagcgaact cgtcggggcc gctctccacc agcaagcctc gctcgaccag ctcgcgcagc
    17401 gcctccacca gcgcggattc atcggtaccg gtgaccgcgg tgaacaggtc gaacggaacc
    17461 cggtgaccga gcacagcagc cgcctcggcg acccgacggc ccaccggtgg cagctcgtcc
    17521 acctgccggc gcaacacctc ggcgaggctc cacggcaacg gctgctcgcc cagccgtgcc
    17581 ggatcgccgc cctcgcaccc ccgcagcaac tcctccagaa agaacgggtt gccgccggtg
    17641 cggtcataga ggaccgccgc gctgcggtgt ggcaccggcc ggccggcgac gctggccagc
    17701 agcgcggcgg tgtcggcctg gtgcaacccg gacaaccgaa gatgggtcac cgcatgccga
    17761 cgctccagcc gggccagcaa cccggcgagc gggtgccgat ttgtgatctc atccggccgg
    17821 taggtgccga ccagcaactg tggcgcgtcc cggtcagcga gccgctcgaa gagcgcggcg
    17881 ctctccgagt cgatccagtg cagatcctcg aagacgatca ccgccggaac gtccccgagt
    17941 agccgctcca ccaccgccag cccggcatgc agccgctcca ccggcgccgc ggcctggtcg
    18001 gtcaccacca acagctccgg gtcgtctgcc ggaaacgcgc cgggcccggc ccccaaggcg
    18061 tccagcaaca cctcgtaggg tcgggccagc gactccggct cggcgtgccc gagcagcacc
    18121 tgcgtggcgg ccggcagccc gcccagcagc tcctgcacca accgggtctt gccgatgccg
    18181 ggctcgccag cgagcagcgc gacccgggac gcgccgacgg cggccaactc ccgcagccgg
    18241 cgcagctctt ggtcgcgtcc gatcatgagc gggctctcgg cccggctggt acgcacgcgg
    18301 ccaggctact cccggacccc gactgggccg tcgcacgccg gccaccggcc cgcagccggg
    18361 cccgcagccg ggtccccagc ccggcccgcc ggtgccgccg tcgcgcccgg tgatcctcga
    18421 cctcgtggac gatcccgtgc cgtgcctcag tcgccatcat gaagatcatc tctgggtggg
    18481 tgaacattgc ccctcctcga agctggtgcc agctcacggg gtcaatgctt cgccggcccg
    18541 gttggcacgg catcggtacc ggcggcgtat cttcaccggc cacccgacgt acccgggcgg
    18601 cgccgggccc actacgtatg cgtacgtcgc gggggggtgt tacggatgcc tgcgtcggcg
    18661 gggacgctgt cgcggtatcg gcggcggcgg ttgggttgcg accgcgacga tggcgtcctg
    18721 gtcgtcctcc ggcgcggtct tgcagcggcg ctctgccccg caccggtcgc agcggtgcag
    18781 cagcgaggtg ccgccaccgg ccgtatcgac cccgaccggc accatcagcc cctgacagtc
    18841 ggcggcgcgg tcacccggat ctacatctac gtgcttggag tgcaggcagt gagcgcagtg
    18901 gttggtgtag ccgtttccga cattccgggt ggcacagtgc tcacagacga agtcttcgac
    18961 catccgcgtg aagctcatcc gggccacccc ctctaccgga aactagcacg cggtgaccgg
    19021 acgcgccggc gatggccgag gccatcgccg gcgcacccag ccagctgtag ctggcgcgat
    19081 cagttgcgga tccgcaccgc gtcggcgagg acgtacccgc tgccggtggt ccaccggctc
    19141 accccgacca cgttgtaggt gccggccgac agcgagaagg aaccgagact cacccaacgg
    19201 ccgccgttgg tgcgctggtt cacatgcacc gtctcgctac cgccgctcgc cgccaccacg
    19261 aacggcgtgt tgttgttgta accgggatcc gccggccacc aggcgtccac ctggtacgtg
    19321 ccggcgctcg gaatgttcgc ccggaaccac gccgcgtcgc tgctgagcac cggctccgca
    19381 aagtggtacg gcgttgcgta ggcctggctc gaccaggacg aggtccccca gtttccgctg
    19441 gcagtgaagt tgccggaggt ggagtcgacg atcgcctcga agtccccacc gccgccgttg
    19501 ccgccgccgt cgatcgcgtc ggcgacatcg ttacgcagct gcgagagcat gccgtagaac
    19561 acgttgcctg ggcaggcggt cgcgctgaag tcccggtgcc cgaagatctg actcggcggg
    19621 atctgatact gctggcaggt gtaggcacag aaatgcacca acgcgtcgta gagcgccgct
    19681 ggcggggcga ccgaagtgta ggtgccctcg ttctcgatgc cgatcgactc gctgttctgg
    19741 accccggcgt gcgcaccgtg cgggaagctg gtgccgccct gcagcgtcgg caggctctga
    19801 tgccgagcct ccatgatgtg gccaccacgg ctgatcgtga actgctgacc cgcgtcgatc
    19861 caaccgttgg tgtccatgtg atggttctgg atgccacggg agagcgagaa ggcgcgcgcg
    19921 agtgaggtgt cggcctggtt cgcggtagcg gtgtggtgaa tgacgatctt gttcgggcgg
    19981 tggttccgga tagtcaccgc cgagctgggc ggccgggcgt tccacgccgc ccggttgtgg
    20041 atggtcggcg cgctgacctg cgccagcgcc ggagccgcag tggtcagggc ggtggcgccg
    20101 gcggctgcgc cgacgccgag taacaccgcg ccgcgcaata gcgaccggcg tcctaccccg
    20161 ggtggggcac cgtcgcaata atcatcgggt gcgtgcatcg tgggggtctc ctctcgagca
    20221 tgaagccgat aaggggggtg gggggggtgt ggtcaggccg gtcggtgtgg ccgccggcta
    20281 gacctgggtg atgcgaaccg catcggcgat gacgtagccg gagccgttgg cccaccgact
    20341 gacgccgatc acgtcgtagt cgccctcggc gagggtgaag gtgccgagct ctacccactg
    20401 gccgccgtcg atccgctggt cgaccggtac ggtctggagc ccatcgacgg tgctaaccag
    20461 gtaaggggtg gcaccgtggt agccagggtc ggctggatac cagacctcga cgcggtagtc
    20521 gccggtgccg ggcacgtcga tctggtacca ggccggatcg ctggcggcta ccggctcggc
    20581 aaaccggtat gtgtccccat atgcctgagg tgagtaggag gaggaccccc agtcgctgct
    20641 ggcgtggaac cggtcgctcg tactgtctat aatggtttgg aagtcaccgc cgccgttctc
    20701 gccgtcgacc accacacccg cgctggggtc gctctcgtga tgcagccgat ccagggcggc
    20761 gacgtggtag gtgtacgtgg cgccggcggc ggtggcgtcg gcgaacgagg tgtcggtggt
    20821 ggtgccgagc agatgccggg cgtcggcgaa gtcgcacgga tccactccgc tggccgcgcc
    20881 gtcgagccga tagacggcgt acgagctggc cccgctgacc gcctgccaac tcacctcgat
    20941 gtcgccgccg gcggtggtgg cggtcaggcc gctcggcgca gccggcgcgg cgccgccgag
    21001 gtggggtgcg accgggacca gggcgggccg ggcatagtgg tcggcgacga gctgactcat
    21061 cgcgccgatc cgatccgcct gcacgtcctt ggcgctgaag tggacgtcac ccagcacctc
    21121 ggggtggtcc cggttgaacg ccagcagatc cgacaggacc gacggctgtt gccaggccgg
    21181 gtcctcgcca gcggcaccgg cccggtaggt cgcctggccg atgaacagct gcacctgggt
    21241 gccggcgacc acgtcggacc accagggtac gagcaccgag tagtccgccg cggcgaaccc
    21301 gatcggccag tagatctggg gtacgacgta gtcgacccac tcttcgacga cccagcggcg
    21361 ggtgtcggcg tagatggcgt cgtacgactg gagtccgttg gtggccgagc cgagcgggtc
    21421 ggtggactgg ttacgccaga tcccgaatgg gctcaccccg aacttgacgt gcgacttctc
    21481 cgcgctgatc tgggcgccca tctccgcgac caattggtcc acattgtcgc gacgccagtc
    21541 gtcgatgtcg gtgaagtcgc cgccgtactc ggcgaaggtg tcctgatcag ggatcggcgt
    21601 gctgcccgac gggtacgggt agaagtagtc atcccaatgc actccgtcga gatcataatt
    21661 actcacagca tgcatcatgg cggctgtgac gtgctcacgc acggccggca cgccggggtc
    21721 gtaatacagc tggcccccgt acgagaaaac ccagtcgtcg tgctgccggg ccgggtgctc
    21781 cgggtggagc tgactcaggt cgtcatgggt cgccacccgg tacgggttga accaagcgtg
    21841 aaactccagg ccacgagcgt gcgtctcgtc gatcatgaac tccagcgggt cgtacccggg
    21901 gtcgctgccc tgactcccgg tcaaccagtg cgaccacggc tcgtacggcg agggccagaa
    21961 cgcgtcggcg gtcgggcgaa cctggacgat gaccgtgttg agctggtgtt cctcggcgag
    22021 atcgagctgc gcccggtact ccgcctgttg ttgcgcggcg ctgagcccgg agctactcgg
    22081 ccagtcgaga ttagccacgc tcgcgatcca catcgcgcgc agttgccgtt tcggcagcgc
    22141 cggatcggtg gcacactggg agctaccagc gtcggctgcg gccgggtcgg ccacatcggc
    22201 cgggtcggtg gtgacggcac cggcggagct gacgctgacc gcgccgctga ccagcagcaa
    22261 tgcggcgacc gcgatgatcc gtccagtgag ggcgggggcg cgcgaggcgc ggagggggct
    22321 gggcacaggg gctcccgggg ggtggggggc taacggggtg ggctagacct cacacgcggg
    22381 acgctaagcc atccgcgcga catatgtcta gaccactatg aaagattttc cccggtattt
    22441 atctgtaaag ctctatgcca atgcgctctg acctcactcg acaaccgagg gtcaccccgg
    22501 tcactcatat ggccggtccg gcggcggcac cacttcccac gtctccacct caatgtaggg
    22561 aatggtcgcc tcgttgatcg gatccaccgt ggtctgctcg acgtacgtcc cgatcaccgc
    22621 cacccaggta tcgtcggcca accccaccgg agcctccgcc cccaccatcc cgaccttgat
    22681 cggccgagcg tccgcggcgc aacacgagag caccagccga gccaagaact gctcctgctc
    22741 cccctcgtcc gccccgcccc gccggtcact ggtgaggaaa ccggtgagct gaatccgacg
    22801 gtcggccaac gaccggccct cgtcccagac cgcccgcgag gcgtagtcca acaccggcag
    22861 ctccaccagg ctcacctccg gcaacggggg aaagtctgcc ggccgctgat cgatcgagag
    22921 cgcggtgccg gtggtgccgg ccgagtagga gcccaacgcc ggcggcgaga ccagcagcag
    22981 ccccagcacc ggcgccacca gcagccaagc gacccgcggc tcccggtggc cgtggccatg
    23041 gc
//
