LOCUS       NZ_CP070499            25116 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Natronosporangium hydrolyticum strain DSM 106523 chromosome,
            complete genome.
ACCESSION   NZ_CP070499
VERSION     NZ_CP070499.1
KEYWORDS    RefSeq.
SOURCE      Natronosporangium hydrolyticum
  ORGANISM  Natronosporangium hydrolyticum
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Natronosporangium.
REFERENCE   1  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Natrosporangium hydrolyticum gen. nov., sp. nov, a haloalkaliphilic
            actinobacterium from a soda solonchak soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) Bioinformatics, Leibniz Institute DSMZ,
            Inhoffenstr. 7B, Braunschweig 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-MAY-2020
            Assembly Method                   :: HGAP v. 4
            Assembly Name                     :: 999_Micromonospora_sp_DSM106523
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 580.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016925615.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 06:45:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,188
            CDSs (total)                      :: 5,131
            Genes (coding)                    :: 5,046
            CDSs (with protein)               :: 5,046
            Genes (RNA)                       :: 57
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 85
            CDSs (without protein)            :: 85
            Pseudo Genes (ambiguous residues) :: 0 of 85
            Pseudo Genes (frameshifted)       :: 18 of 85
            Pseudo Genes (incomplete)         :: 72 of 85
            Pseudo Genes (internal stop)      :: 4 of 85
            Pseudo Genes (multiple problems)  :: 8 of 85
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:11:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3223044
            Orig. end                         :: 3248160
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070499.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25116
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="16"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25116
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25116
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15116](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15116
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(267..698)
                     /locus_tag="JQS43_RS14320"
                     /old_locus_tag="JQS43_14250"
     CDS             complement(267..698)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013970.4"
                     /locus_tag="JQS43_RS14320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14250"
                     /product="type II toxin-antitoxin system VapC family toxin"
                     /protein_id="WP_239674886.1"
                     /transl_table=11
                     /translation="MIGYLDTSAYVPLLIDEPTSEVCRRFWDDPDEVVSSRLLYVETAA
                     ALAQARRLGRLTDPAHRRSLQLLDQMWSEIDVAEVDELVVGRAASLADRLELRGYDAVH
                     CASAEQLRSDDLVAASGDRRLLAAWTELGLATYDSNRQH"
     misc_feature    complement(324..326)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            910..1167
                     /locus_tag="JQS43_RS14325"
                     /old_locus_tag="JQS43_14255"
     CDS             910..1167
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013561.4"
                     /locus_tag="JQS43_RS14325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14255"
                     /product="CopG family transcriptional regulator"
                     /protein_id="WP_239674887.1"
                     /transl_table=11
                     /translation="MTRTNIYLEERQTAILDRIAGEEGVSRAEVIRRLIDRALAGRDDD
                     LTADLAAIDESFGALGELDVPARGASDREAHLSRMWQVAA"
     gene            1164..1547
                     /locus_tag="JQS43_RS14330"
                     /old_locus_tag="JQS43_14260"
     CDS             1164..1547
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013970.4"
                     /locus_tag="JQS43_RS14330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14260"
                     /product="type II toxin-antitoxin system VapC family toxin"
                     /protein_id="WP_239674888.1"
                     /transl_table=11
                     /translation="MILIDSDVLIAHLRGVEPARDWLRKARTTGPLAVSVVSIAELTGG
                     MRSAERREVFALLGALRAEPVTELVARRAGEFMRQYRRSHNGIGIADYLIAATAELHGQ
                     QLATLNVRHFPMFADLRPPFEVP"
     gene            complement(1915..2172)
                     /locus_tag="JQS43_RS14335"
                     /old_locus_tag="JQS43_14265"
     CDS             complement(1915..2172)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS14335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_14265"
                     /product="hypothetical protein"
                     /protein_id="WP_239674889.1"
                     /transl_table=11
                     /translation="MILRVFHQTRTRPTGVTRRVVSDIQLIIDGEDLTEQVAGQLDRAL
                     GLMSPVFAQSPPPPAAPPPRQVPTGPSNAVRERRHSVIRQ"
     misc_feature    complement(2164..2166)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2231..2467)
                     /locus_tag="JQS43_RS14340"
                     /old_locus_tag="JQS43_14270"
     CDS             complement(2231..2467)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS14340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_14270"
                     /product="hypothetical protein"
                     /protein_id="WP_239674890.1"
                     /transl_table=11
                     /translation="MDSPLQTWITGWLAFLELALPLAFAVVVLAHGCYRVVMRRGGWPW
                     KTMVFGLGAALVFLLLTNVVSVADWFVEELPIN"
     gene            complement(2467..2724)
                     /locus_tag="JQS43_RS14345"
                     /old_locus_tag="JQS43_14275"
     CDS             complement(2467..2724)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS14345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_14275"
                     /product="hypothetical protein"
                     /protein_id="WP_239674891.1"
                     /transl_table=11
                     /translation="MRGLAEATTEPAAAADSLAVYNPPTDVDIAAAELELMAPYVGPAP
                     IGGLERQRVAQMIATLEGAGAVPPGVTPGDVVAFDLLPGA"
     gene            complement(2678..3316)
                     /locus_tag="JQS43_RS14350"
                     /old_locus_tag="JQS43_14280"
     CDS             complement(2678..3316)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020650.4"
                     /locus_tag="JQS43_RS14350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14280"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_239674892.1"
                     /transl_table=11
                     /translation="MLPPQRRLPRRTVLAAGMAAAAAAPAGALLSACGSGQTSVTRTIR
                     DEITYLDGVGPFGREAYVHLTVERGYFADEGLVVNVEPGGAGANAATLLAGGRVQFAAV
                     DAAGVIIRHGLGEDTDTVIVSAVQQQTTAAILSLTADRPRDLEGATIGGLEGSVIETLF
                     PTYAELSDVRHGACDHPRYRFAGARPGSALQRGDHAWAGGGDHRAGGGC"
     gene            complement(3475..3939)
                     /locus_tag="JQS43_RS14355"
                     /old_locus_tag="JQS43_14285"
     CDS             complement(3475..3939)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS14355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_14285"
                     /product="hypothetical protein"
                     /protein_id="WP_239674893.1"
                     /transl_table=11
                     /translation="MSQLAGLVWSVVRATWPIPLPLDVRRAAASEAIQAMLTAGHPPAS
                     PSELVSVGIRGVALAQRRHTPSPALLVPSDLANWALSSAAPDTSEQRLVDLITLAQVWA
                     MLPEADQEAVAAVVEHRELPPAAEALGVDVPELQRRLSQARRRFATLLGQ"
     gene            complement(4085..4717)
                     /locus_tag="JQS43_RS14360"
                     /old_locus_tag="JQS43_14290"
     CDS             complement(4085..4717)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS14360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_14290"
                     /product="hypothetical protein"
                     /protein_id="WP_239674894.1"
                     /transl_table=11
                     /translation="MNDHPMHELVALARESSTSGLAAAIHEQQLTDPQSIAEITVAALV
                     TLAGAPRIDTPELLAHLDRIGPRQRVVGRAGPRLSGNPRRWDRSGAACRPNGPDLSAVP
                     EFRRCYRGARCAEVGPPVIDLREHLGNHMPRQPDWHCESDGFDWPCPLARYRLAQAFDH
                     APGDLAAEMTLWMEAAIVARLTDDPEQLWDRFLAWTPGTDRRQRAAP"
     misc_feature    complement(4481..4483)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4932..5120)
                     /locus_tag="JQS43_RS14365"
                     /old_locus_tag="JQS43_14295"
     CDS             complement(4932..5120)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS14365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_14295"
                     /product="hypothetical protein"
                     /protein_id="WP_239674895.1"
                     /transl_table=11
                     /translation="METNHLRPVPDGDQVLAPGVPHWSDLLRPGAAAIDPPTQQLPALA
                     PLLTRAARHRSRQVGNP"
     gene            complement(5439..6635)
                     /locus_tag="JQS43_RS14370"
                     /old_locus_tag="JQS43_14300"
     CDS             complement(5439..6635)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="JQS43_RS14370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14300"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_239674896.1"
                     /transl_table=11
                     /translation="MPRRTFTDPRFPAMLREIRQQRGMSLRDLYNASYVGRSTISQLET
                     GKTQPTPSTVRALDSALEAKGQLMALVSEREETEPATGLWETAELMNRLRASDVSPAVV
                     EGIHATVYAMCCDYGWQDAQQLRAEGLRWLREVDRLLRSPVGLRAHRELLVAAGWLALL
                     VGCIEYDLQMRASAEATRTAALELATEVGHGEIAAWAWEMSSWFALTQGRYRDVVTAAD
                     AGMGAAGEHTAAVQLAGQAAKAHARMGDPAAVEQALTVGRQLLDRHQPPSRPDHHFVVD
                     PDKWDFYAMDAYRLVRRDDLAAHHALRVIELGTAADGTEKAPMRMAEARLTLSTVAARA
                     GELEQAVAVGLEAFQSRRRSMPTLLMVAQEVGQELQRQHREGRPVQDFRAALRDLSNS"
     misc_feature    complement(5541..5543)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7089..8288
                     /gene="fxlM"
                     /locus_tag="JQS43_RS14375"
                     /old_locus_tag="JQS43_14305"
     CDS             7089..8288
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="JQS43_RS14375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14305"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_275580899.1"
                     /sec_met_domain="PCMT (E-value: 1.3e-42, bitscore: 144.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHAMVDGINSWQPLSEPVAAAMRQVPRHLFVPDASLEEAYSNST
                     VVTRRDQDGIATSSSTGPGLMGAMLDQLQLRPGMPVLEIGAGTGYNAALLAALVGPAGH
                     VTAVEITPEVADDARAALTAAGVTNAEIVCGDGEYGHRPNAPYDRIIATAGAWELPQSW
                     GDQLAEGGVLVAPLRIKGLTRSVALTRDPSGVWRSHSALNCGFMPIRGRGAMPERNIRL
                     AEDLTVRFDDGQDVDADELRRVASPPGEVRWSRVLIDRPLDLLDLYLAELDGFCRVLAS
                     ASVTERGLIEPVAGWGSMGAATRQALGYLTKRTSLDNQYLDELGVCAYGPAAASMLDQL
                     TERVDRWRRTREAIAGVRIEIHPPGRGEVADALMTVEKRHSRVVVRPRQESERRAPQPG
                     "
     misc_feature    8300..8317
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.14"
                     /tool="antismash"
     gene            8372..9643
                     /gene="fxlM"
                     /locus_tag="JQS43_RS14380"
                     /old_locus_tag="JQS43_14310"
     CDS             8372..9643
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="JQS43_RS14380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14310"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_275580900.1"
                     /sec_met_domain="PCMT (E-value: 1e-41, bitscore: 141.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSANHTRQTEDFSALRASMVDDLRELEMVTTEPVAAALLAVPRHL
                     FAAGEPPETVHDVNATLAPKLAPDGTKLSVISAPHIQAAMLEQAQIKPGMNVLEVGSGG
                     YNAALLAELVGPNGAVTTVDIDPEICELARSRLDIAGYRHVRVLQADAEHGVPERAPYD
                     RIIVTVGAADLPPAWIHQLHPEGRMVVPLQFAGITRLVAFDHNGAGGLISRSYRLGSFV
                     PMQGDGAQDEHLVPINGAVTLRVDQAATAETLDVAALRKAVHTPRIARWSGTAFDFPDE
                     LDLFLLTCEPEIPMYVLYAGESLVEQEVFTPAALRGAPTLVDGGSFGYRSKRTNNQIGA
                     APGSGGGRRYEEQTAGFESGVVAYGPNAETVADQYLQLLRRWARDYRRRCAARIEYHPN
                     SSDVGHVNGWRTNKKHGTVTVNWP"
     misc_feature    complement(9653..9667)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            9692..9889
                     /locus_tag="JQS43_RS14385"
                     /old_locus_tag="JQS43_14315"
     CDS             9692..9889
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="JQS43_RS14385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14315"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_239674899.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 5.3e-14, bitscore:
                     50.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNALDQTDTTKSHPARDGEQAGADDWELDIKFIEAGDAVKHLIY
                     MTNDQCGTTCQSACTNTCPS"
     CDS_motif       9692..9739
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSNALDQTDTTKSHPA"
                     /locus_tag="JQS43_RS14385_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9740..9889
                     /prepeptide="core"
                     /locus_tag="JQS43_RS14385_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-12.30"
                     /molecular_weight="5197.6"
                     /monoisotopic_mass="5194.3"
                     /core_sequence="RDGEQAGADDWELDIKFIEAGDAVKHLIYMTNDQCGTTCQSAC
                     TNTCPS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSNALDQTDTTKSHPA"
                     /leader_location="[9691:9739](+)"
                     /alternative_weights="5215.7"
                     /alternative_weights="5233.7"
                     /alternative_weights="5251.7"
     gene            10001..13027
                     /locus_tag="JQS43_RS14390"
                     /old_locus_tag="JQS43_14320"
     CDS             10001..13027
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="JQS43_RS14390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14320"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_275581093.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.7e-185,
                     bitscore: 616.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.9e-15,
                     bitscore: 55.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.1e-27, bitscore:
                     94.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGPTGRQLPHWPDLTGQQGLTAWPQWLRQVLAQPEFSAALEHASP
                     VLAARARAVSAGGPLSDRGTRRVVFSVMRYLLRASGRATPYGLFAGVAPGAVAASGVAH
                     VGHGHRAVVRVRAEWMAALIDRLEADPDLQPLLRVRANNLLAERGGRFVLANPAGQTPD
                     RVPTQQLVRATGPVRAALQLAHNPRVVYELVGKLVDEFEVAATTAGDLLAQMVRHRLLV
                     TSLRPPMTVTDPLGWITAEVEKLLADAASSTAAPARDLMDGLGTAADQVSHRETSVSWA
                     NSRRRQVVDALNTVNPASEASVAVDLRLDATVAVPHTVMDEAARAAGLLVRLARPTTAG
                     WVDWHGRFLERYGPRGVVPVLQAVDPDTGLGYPAGYHGTPPVPAATVTDRDRVLLAIAQ
                     QAALTGRHEIELDETTIGELAGAKPVTSIQPSTELTVGIHAPTIRAVEQGEFRLAIVGV
                     SRRAGTTTGRFLDMLETGDRERIADQYSALPTLTRGALLAQVSAATPYTVTEDVARAPQ
                     VMSHLIPVGEYHDNRGDIIALDDLAVTADEQRLYLVSMSRRRVVEPVVLNAVELVHHTL
                     PIVRFLVEIPTAVSTPCVAFDWGPAAARLPFLPGLRHGRTILSPARWLLPAAALPAPGG
                     TWQEWSRSLAAWRAETTCPATVYLGDGDQRIRLDLAEPAHQALLRDHLARHGTAAFRAA
                     PAEDAAGWIGGRPHEIVIPLVVDVEPTPPPQLADPIEPVTVRDHGHLPGCGGRVYAKLY
                     GHPDRQTTILTEYLPLLLDQLGGGCRWWFLRYGDPEPHLRLRVTGPADPATVGAWAQRL
                     RRAGLASRVVFDTDYPETARFGGTDALAAAEEVFAADSAAAIAQLTAADNRQGPDAAAL
                     TAASLLDLIIAFIGDGTEAMRWAIDHTRAHRPAPPRAVYDQAVLLANPHNQAELAGFPG
                     GARVLASWQQRRRALTAYRDRLRTCGAFPPEVLLPDLLHLHHTRMAGPDLEAERRCLHL
                     VRAAALSWTIRSSNGHDPT"
     aSDomain        10415..10684
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JQS43_RS14390_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.00E-17"
                     /identifier="RREFam001.1"
                     /label="JQS43_RS14390"
                     /locus_tag="JQS43_RS14390"
                     /protein_end="228"
                     /protein_start="138"
                     /score="55.6"
                     /tool="antismash"
                     /translation="VRANNLLAERGGRFVLANPAGQTPDRVPTQQLVRATGPVRAALQL
                     AHNPRVVYELVGKLVDEFEVAATTAGDLLAQMVRHRLLVTSLRPP"
     gene            13014..14258
                     /locus_tag="JQS43_RS14395"
                     /old_locus_tag="JQS43_14325"
     CDS             13014..14258
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="JQS43_RS14395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14325"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_239674900.1"
                     /sec_met_domain="LANC_like (E-value: 2.9e-37, bitscore:
                     126.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPPNPAALAAAEQVADAFAQPRHVRYLTTSGRARPQSLAGGAVG
                     IALLHLERLCSGHGDETTAHTWLSHAAAEPVSAGDNANLFHGAPALAFALHVAAALSGR
                     YHRTLAALDDKTIAITRGRLAAARSRINRGDRLPMREFDLVHGLTGLGAYHLAQHPDHP
                     VTREVLTYLVRITQPSATARKPGGDDLPAWWLASGLNGNPDPQAYPQGHGNLGVAHGIS
                     AVVALLSLAILRGLPVPGARQALADLCGWIDRWCQDSETAPWWPGFVTTSQVHGSQPPA
                     RPRPSWCYGIAGTARAQQLAGMAMADTTRQHLAEAAMLATLRDPHQLAQLPEIGLCHGK
                     AGLLQAGWRMAADAEDPHLATTLGSLTDELITQLSGQVDDPDLMDGTTGAALALHTIGT
                     GTGPSSGWDTFLLLT"
     misc_feature    14187..14189
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14277..15116
                     /locus_tag="JQS43_RS14400"
                     /old_locus_tag="JQS43_14330"
     CDS             14277..15116
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018909377.1"
                     /locus_tag="JQS43_RS14400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14330"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_239674901.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.9e-32, bitscore:
                     111.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPPLWRQFDIEFPDYSRAEPAAVTHLAPLLTTTEADGLIDGWWF
                     IRKRPCWRMRYLPTDNPPTIQEHLRAALGRLQQAQHITRATEVIYEPETRAFGGPEAMA
                     VAHQLWHRDSRNLLAHLAATTDEPARHRRELPLLLYSTMLRAAGLDWYEQGDVWARVAR
                     SRPPAAVGDRPNLTATMRRLLTVDTDDLTRSSRATAGLADWTAAYADAGRNLARLNAGG
                     FLERGLRHVLAHHIVFAFNRIGLPAATQAVLAATASEVFFDDPPQPQHPRSASAGLS"
     gene            15344..16255
                     /locus_tag="JQS43_RS14405"
                     /old_locus_tag="JQS43_14335"
     CDS             15344..16255
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS14405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_14335"
                     /product="hypothetical protein"
                     /protein_id="WP_239674902.1"
                     /transl_table=11
                     /translation="MLLRRPPQNPKQAIASLEPIVNLARLRTRAGDGPGAWSLLETLHQ
                     AITTRTDINIDGIHIPAACLTRTPDLHRELSTWLWTVLLADGGRALTLAGRWAEAHRRL
                     EQHRGVGRRMLDGRQIAVLAHAVAGDHDTALTLLEDTERGEAWEAAVTTCLTMLCRPSS
                     AGPADLRTVRQQLEPPPAELVVFHTRLGLCLLDALPSNALSAVPYIAAGLLRHAVTDGY
                     AARDLLNHPLCRSIATGQQLQALTDVVGACGLDAGAIPADSLGDITAALDQAGTLLAGP
                     GHGNQIAATLPARSALTNRATS"
     misc_feature    15419..15421
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16376..17572
                     /locus_tag="JQS43_RS14410"
                     /old_locus_tag="JQS43_14340"
     CDS             16376..17572
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013315.4"
                     /locus_tag="JQS43_RS14410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14340"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_239674903.1"
                     /sec_met_domain="PCMT (E-value: 9e-35, bitscore: 118.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDINWQPHAANLAKDLTDIGAIRDPDWAVTFAATPRHVFVPRFY
                     QMDEFNQPRTLVDSADSVEQDRPLETIYSDQVLVTHYQVLDGKMPDGQEIRTATSSASM
                     PSIVATMLDRLTVQVGQRVLEIGTGTGYNAALLANRLGDEHVTSIEVEPETAAEAAEHL
                     HTAGLRPALVVGDGAAGHPARAPYDRIIATCAADRIPSAWIDQLADGGIIVAPLAVGGM
                     LVVLHKTSLGTVSGRVDAQPVGFMPLRPAGQHMPDGWVADIPNTRLEHHTTTCVEPQAW
                     ADPNFQLWLGLHRPGMQTSLWLDDAGGYYASGVYTATGRATVDYTAGASGDWPVTQDSE
                     RVWDTVEAAWVTWQQHGRPDRTRIGITAQVDGDQYAWIDDQDGPMRWPLPTPKPCYGT"
     misc_feature    17249..17251
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17613..17628)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 21.03"
                     /tool="antismash"
     gene            17654..17830
                     /locus_tag="JQS43_RS14415"
                     /old_locus_tag="JQS43_14345"
     CDS             17654..17830
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS14415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_14345"
                     /product="hypothetical protein"
                     /protein_id="WP_239674904.1"
                     /transl_table=11
                     /translation="MRTPLVRPPALRPCETVAIVSTSSPVPADELARLRRPVLLGAATV
                     MDRIFAELPAGKA"
     misc_feature    17868..17884
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.33"
                     /tool="antismash"
     tRNA            complement(17904..17978)
                     /anticodon=(pos:complement(3240988..3240990),aa:Val,
                     seq:gac)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="JQS43_RS14420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="JQS43_14350"
                     /product="tRNA-Val"
     gene            complement(17904..17978)
                     /locus_tag="JQS43_RS14420"
                     /old_locus_tag="JQS43_14350"
     tRNA            complement(18000..18070)
                     /anticodon=(pos:complement(3241080..3241082),aa:Cys,
                     seq:gca)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="JQS43_RS14425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="JQS43_14355"
                     /product="tRNA-Cys"
     gene            complement(18000..18070)
                     /locus_tag="JQS43_RS14425"
                     /old_locus_tag="JQS43_14355"
     tRNA            complement(18106..18178)
                     /anticodon=(pos:complement(3241187..3241189),aa:Gly,
                     seq:gcc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="JQS43_RS14430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="JQS43_14360"
                     /product="tRNA-Gly"
     gene            complement(18106..18178)
                     /locus_tag="JQS43_RS14430"
                     /old_locus_tag="JQS43_14360"
     gene            18523..19392
                     /locus_tag="JQS43_RS14435"
                     /old_locus_tag="JQS43_14365"
     CDS             18523..19392
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014444911.1"
                     /locus_tag="JQS43_RS14435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14365"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_239674905.1"
                     /transl_table=11
                     /translation="MNLAEPTPDPGLIGVTGATGGVGGRVARRLAAAGARQRLVVRDLT
                     RAPDLPGAEAVQASYEDLPGMRQALAEVDTLLLVSASEHPDRVALHRTAVDAAVVTGVT
                     RVVYLSFLAAAADATFTFARDHWHTEQYLRGTGLPCTFLRDSLYQDVLPYFPDRAGVIR
                     GPAGDGRFAPVARDDVAAVAATVLLAGDGRHDGQSYDLTGPELLTMAAVAAELSRATGR
                     DISYHPETLPEAYESRARFGAPEWEVTGWVTSYAAIAAGELDLLADDVARVTGRPPTRF
                     ADYLAAGA"
     gene            complement(19371..21704)
                     /locus_tag="JQS43_RS14440"
                     /old_locus_tag="JQS43_14370"
     CDS             complement(19371..21704)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025851.4"
                     /locus_tag="JQS43_RS14440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14370"
                     /product="glycoside hydrolase family 95 protein"
                     /protein_id="WP_239674906.1"
                     /transl_table=11
                     /translation="MRLWYEQPATDWEREALPIGNGALGAMVFGGVAAERLQLNEKTLW
                     TGGPGSAEGYQHGDWPPPGRPGVLPELRRRLDEVGELPPDEVAELLGQPRLGYGAYQPL
                     ADLWLHFPEPAGQVTGYRRELDLTDAVARVRYTADGVTHHREYLASHPAGVIAGRVWAD
                     QPGSVTLTVRLAAGPLGAATTVGQRGIRLRGELPDNRLRYEAQLRLHVVGGAVTEAAGE
                     IRVSGADEVILWLAAGTDYAATYPDYRGEDPAPRVGRTIEAAAGQPYPTLRGAHLADYQ
                     QLAGRVSLDLDAPPPNLPTDELVRRHGDHTADPAAERALAALHFAYGRYLLISSSRVGS
                     LPANLQGVWNDSATPAWSADYHLNINLQMCYWPAEVTNLAETAPPLHEFIDALRAPGRV
                     TAREMFDSDGWVVHDETTPWGFTGVHDWPTAFWFPEAGAWLCRHLWEHYLFTHDSEFLR
                     HRAWPVLAETVEFWLANLHIDATTDTLLVSPSYSPEHGPYTAGAAMSQQLVADLFRATL
                     AAAAELAIDPPAGLADAAGRLAPGLRIGAWGQLQEWRADRDDPADEHRHVSHLYALHPA
                     DQISPLAEPELARAAEVSLDARGDGGTGWSKAWKISFWARLRDGDRAHRMLTALLRECT
                     LPNLFDIHPPYQLDGNLGAVAGVAEQLLQSHRGVLDILPALPTAWPAGRVTGLRARGGV
                     TVDIAWRDGAPTEVTLLPDRTGALTIRCPLLPEQPLRRLDTGEQVPLRPGELGGWRGTV
                     EAGRRYRIGGPATPPPADQAPAAR"
     gene            complement(21719..24541)
                     /locus_tag="JQS43_RS14445"
                     /old_locus_tag="JQS43_14375"
     CDS             complement(21719..24541)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="JQS43_RS14445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_14375"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_239674907.1"
                     /transl_table=11
                     /translation="MISIALLGPVAVHDGERDLTPGPAKHRALLAGLALNVGSLTTVER
                     LVAVIWGDAPPRSAESVLRVYVSALRRLLGADLIKTVPGGYQLLADPEQVDVWRFEQLL
                     GQARQCAPDQPAAASALLADALALWRGEPVADLDSDELRRGDAARLTELRLAAIAERID
                     LDLRIGRHQELTGELRRLVAEQPLRERAWAQLVIALHRSGRRSEALATYQQARQTLVTE
                     LGLEPGVELRQAHDQVLADTGEQAAPAAPEQPELRVPRELPPDINDFTGRGQALAWVAG
                     ALATAETAPVHLVLHGPGGVGKSTVAIRAARSLADRFPGGALYVDLLGGGDGPLPPASA
                     LASLLRSLLGPHATLPDELADRAQLFRTLLDGRRALVLLDQAHDETQVRPLLAAAPGCA
                     TLITSRSGLAGLAAAAAYQLDTLPTKESMTLLAQVAGAQRVAAEPAAAEQIVELCGGLP
                     LAVRIAGARLARRAGWSLGYLAGRLADEHRRLDELAAGDLAVRGSIALGYHGLAEPEQQ
                     LFRRLGLLSAPDLAPWTAAVLLAGAEPTPAVETRAEQILETLVDSGLLQPLGVDVAGQP
                     RYRCHDLTRLFAREQSTDEPADPLWRALSRRVLRLSRRARAQLLPAEPGSGETTRLAEP
                     ALQVGSRQIREAADWLTAERGLLVATVADLHQAGWHEAAWRLAFYLAPYLASRSQLEEW
                     RRTHELGLAAARAAEHRRGMALMLRGIGDLHRVERRLPEAADALRESLHRLTELGDRAE
                     EARTRCRLGWAELAAAELVGAEVCFEGAVETFVRHNDLRGCADAWRGLAEVQRRRRQLW
                     EAADFLQRSVDGYRQLGDPRGEAETLRELADVQLEQGSPGQARVSVERAAATLRRLGDP
                     LAEARVAVTRARLCLAESDAEAARVAAGHARQIFADHSDQAGLAAVAELGLVDATAPGG
                     AQEQQLAAPD"
     misc_feature    complement(24914..24927)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.36"
                     /tool="antismash"
     misc_feature    24938..24954
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.16"
                     /tool="antismash"
     misc_feature    complement(24970..24985)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.68"
                     /tool="antismash"
ORIGIN
        1 cggacatacg agccgcaaca ccgctggtgt ggcctggact cgcgctgttc gcgtacctcg
       61 cggcgcttag cgtccgcacc tacgccgagg cggctggggc gctggtggct cacctccgcg
      121 ccgcaacaac gaccacgacg ccgacctttc gtgcagcgcg cggatggtca ggtggatgga
      181 cgccgccgtc atcccgctcg ccctcctcgg cccgtgcaat cgcacgccag gcgaccgccc
      241 caggtgaggg cgcctcgccg gatgggctaa tgctggcggt ttgagtcgta ggtagcgagg
      301 ccgagttcag tccaggcggc gagtaatcgt cgatcgcccg aggctgccac gaggtcatcg
      361 cttctgagct gctctgccga cgcacagtgc acggcatcgt agccgcgcag ctcaagccgg
      421 tctgccagcg acgcggcccg gccgacaacc agctcatcga cctcagccac gtcgatctcc
      481 gaccacatct ggtccaacaa ctgcaggctc cgccggtgcg ccgggtcggt gagccggccc
      541 agtcgccggg cctgggccag agcggcagcg gtctccacgt acagaagccg actcgacacc
      601 acctcgtcgg ggtcgtccca gaagcgccgg cacacctcgc tggtcggctc gtcgatcaac
      661 agtggcacgt aggcggaggt gtccaggtag ccgatcaccg ccgctgctca tcaaccaggt
      721 cgctgactgg ctaccgccat ggttcgagta ggtagagaaa gtgggccgaa ctatccacaa
      781 tccgaatcgc gcacagatag cacgcgggcc ggtcgtgacc ggcatcgtcg gggctacggc
      841 ccaagggcgg ggtcggtagg cggcagttag ctcggcctag ttcgtgcccg ccggtgtatg
      901 atgtggtgta tgacgcgcac caacatctac ctcgaggagc ggcagaccgc gattcttgac
      961 cggatcgctg gcgaggaagg tgtgtcccgt gccgaggtca tccgccggct gatcgatcga
     1021 gcgctggccg gccgcgacga tgatctcacc gcggacttgg ctgccatcga cgagtcattc
     1081 ggcgccctcg gcgagctgga tgtgccggcc cgcggcgcca gcgatcggga ggcgcacctg
     1141 tcgcgcatgt ggcaggtagc cgcgtgatcc tgatcgacag cgatgtgctc atcgcccacc
     1201 ttcgaggagt cgagccggca cgtgactggc tccggaaggc ccggaccacc ggaccgctcg
     1261 cggttagtgt cgtctcgatc gccgaactca ctggcggtat gcggtcggcc gaacggcggg
     1321 aggtgtttgc cttgctcgga gcacttcgcg cggagccggt caccgagttg gttgcccggc
     1381 gtgcgggcga gttcatgcgc cagtatcgtc gcagccacaa cggtatcggc atcgccgact
     1441 acctgatcgc cgccactgcg gagctgcatg gacaacagct cgccaccctg aacgtgcggc
     1501 acttcccgat gttcgccgac ctgcggccac cgttcgaagt tccgtaacta cgctgcggtg
     1561 ctcgatgctg tccgggatct tcgtcggccc cgagcatgtc cgctgccaca tggtcggggc
     1621 ctcagtgatc gccgttgacg acgcagaagc cgttgccttc cggatcccgc atccagacat
     1681 ggtcctcgga ccgaaaacta tggtgggccg aacttgccag aatacgaacc ggactcccgt
     1741 tcggcggtca cggttggggc cgtccggagt cggtcgacga cgcgctcact gagatgatct
     1801 tgcgtttgcg tcgccgcgcg acactgttta aacagccgac atctgccctg cctggagggc
     1861 aatcccatgc ttgtcgattc gcgaggagtg cttttgtggt tggtttgctg cgtatcactg
     1921 ccggattacc gaatgccgtc gctcccgcac cgcgttgctg ggcccggtcg gtacctgtcg
     1981 aggcggcggt gcggccggcg gcggaggaga ctgggcgaac acagggctca tcaaccccaa
     2041 tgcgcggtcg agctgacccg cgacctgttc agtcaggtcc tccccgtcga tgatcagctg
     2101 gatatcggag accacccggc gtgtaactcc ggtggggcgg gtccgggtct ggtggaagac
     2161 tcgtaagatc acccggggac tttccacagc gatgcaccag gagccgtgat cgtcacggcc
     2221 caggcacgcg tcagttgatc ggaagctcct cgacgaacca atcggccacc gagacgacgt
     2281 tagtcagcag taggaacacc aacgcggccc ccagcccgaa gaccatcgtt ttccagggcc
     2341 agccgccgcg tcgcatgact acccggtagc agccgtgggc caacaccacc acggcgaagg
     2401 ccagcggcag ggccagttca aggaaggcca gccatccggt gatccatgtc tgcagcgggc
     2461 tgtccactac gcgccgggca gcaggtcgaa cgccaccacg tcccccgggg taacccccgg
     2521 cggcaccgcg ccagcacctt ccagagtggc gatcatttgc gccacccgtt gccgctcaag
     2581 gcccccgatg ggcgctgggc cgacgtaggg agccatcagc tccaactcgg cggctgcgat
     2641 gtcaacatca gtcggtgggt tatacacggc caacgaatca gcagccgccg ccggctcggt
     2701 ggtcgcctcc gccagcccac gcatgatcgc cgcgttgaag cgccgaacca ggtcgggctc
     2761 ctgcaaagcg atatcgcggg tggtcacatg caccgtgccg aacatctgac agctcagcgt
     2821 aggtgggaaa aagcgtctcg atcacgcttc cctccagacc gccgatcgtg gcgccctcaa
     2881 ggtcgcgagg gcggtcggcg gtcagtgaca gtatcgcggc ggttgtctgc tgctggacgg
     2941 cagacacgat cacggtgtcg gtgtcctcac ccagcccgtg gcggatgatt accccggccg
     3001 cgtcaacagc ggcgaactga acccgcccgc cagcgagcaa cgtggccgcg ttcgccccgg
     3061 ccccgccggg ttcgacgtta acgaccaagc cctcgtcggc gaagtatcca cgctcgaccg
     3121 tcaggtggac ataggcttcg cggccgaacg gtccaacgcc gtccaagtag gtgatctcgt
     3181 cccggatggt tcgggtgacg ctggtctgcc cgctgccgca ggcgctgagt agcgccccag
     3241 cgggggcggc ggcagcagcg gccatcccgg cggcgagcac ggtgcggcgc ggtaggcgtc
     3301 gctgtggagg cagcatagaa agcaccttcc tcatggttgt tcggggtggg tcgggcccgg
     3361 ggcagcacgt ggaggcgggc gccccgggcc cggttgtgca cctgccgtcg acgatgcggg
     3421 agcacagcaa cggcggcagc aggtggtctt ggcgggcatt gctcggcggg ccgcctactg
     3481 gcccagcagc gtcgcgaacc ggcgccgggc ctggctgagg cgccgctgca gctccggtac
     3541 atcgacgccg agggcctctg ccgcaggcgg cagctctcgg tgctccacca ccgcggccac
     3601 cgcctcctgg tcggcctctg gcagcatcgc ccatacctgg gcgagggtga tcaggtccac
     3661 tagacgctgc tcggaggtgt cgggagctgc cgacgagagc gcccagttgg ccagatctga
     3721 cggcaccaaa agcgcagggc tcggtgtgtg tcgccgctgc gctagggcta ccccgcggat
     3781 gccgacggat accagctcac tgggcgatgc tggcgggtga ccggccgtca gcatcgcctg
     3841 gatcgcctcg ctggcggctg cacggcggac gtcgaggggc aacggtatcg gccaggtcgc
     3901 ccggaccacg ctccacacca gccctgcgag ctgactcatc gggctacacg cagcatatga
     3961 agtccattcc tcacaatggt gggggctggg cccgggcagt acatggaggc gggcgtcccg
     4021 ggcccgggct tgtacaccta ccgccgccgc tggagggggt tcagcaacgg cgacggcagg
     4081 cggtctaggg ggcggcgcgc tgcctccggt cggtaccggg cgtccaggcc agaaacctgt
     4141 cccacagttg ctcggggtcg tcagtgagcc gggcgacgat cgccgcctcc atccataggg
     4201 tcatctccgc ggcgagatcg ccgggggcgt ggtcgaatgc ttgggcgagg cggtagcggg
     4261 caagcgggca tggccagtcg aagccgtcgg actcgcagtg ccagtccggc tggcggggca
     4321 tatggttgcc gaggtgttcg cgcaggtcga tcactggcgg gccaacttca gcacagcgtg
     4381 cgccgcgata gcagcggcga aactcgggga cagcagatag atccgggcca tttggtcgac
     4441 aagccgcgcc ggatctatcc catcgtcgag ggttgcccga taaacgcgga cctgcccgtc
     4501 caacgactcg ttgtcgcggg ccaatacggt caaggtgagc cagcagctcc ggagtgtcaa
     4561 tcctcggtgc gcctgccagc gtcaccaatg cggcgaccgt aatctcggcg atgctctgcg
     4621 ggtcggtcag ctgctgctcg tggatcgccg cggccagccc tgaggtgctg ctctcgcggg
     4681 cgagcgccac cagttcatgc atcgggtggt cgttcatgat ctagcctgcc ttgaccgcat
     4741 tggccggcct gggcggcgcc gcggccaccg cgctgtcgct gccttgccgg gggttgggtg
     4801 gaggggtgcg gcgggatcga tcggacgagc gatcgccgga gacccgatcc ggcttccgtc
     4861 gcacccctcc ggtctgaggg ggtgtcgggc gaggttgacc ggctcaccga tcacgtttga
     4921 cttggggtcg gtcacggatt gcctacctgt cgtgaacggt gccgagcggc gcgggtgagc
     4981 agcggcgcca gcgccggcag ctgctgggtg ggcgggtcga tagctgccgc cccggggcgg
     5041 agcaggtccg accagtgcgg caccccggga gcgaggacct ggtcgccgtc gggcaccggg
     5101 cgcaggtggt tcgtttccat cggccggtct gggtctgggc gtcgccaggg ccaccacatc
     5161 gctgcctccg cacggttgag ggtgggggaa gcgagagcct ttcgcccgct accccggttc
     5221 cggggggagg ggccgcgccc ctccggcttg ggaccggagc cgcggcgagc ggtgcctgtc
     5281 gctaaccgcg cccccgggga gggttgggtc gtacggcgcc ccttgtggag gcggcgaacg
     5341 acccatgcct gagcttcacc cgcaagggtc gatgattgga agaggttcgc cgtccggtgg
     5401 atgtccgcca ctgcgtccgt tggcgacgga caggcatgtc agctgtttga caggtcgcgt
     5461 agcgcagctc ggaaatcctg caccggccga ccttctcggt gttgccgctg cagttcctga
     5521 ccaacctcct gagcgaccat taacagcgtg ggcatcgacc gccgccggga ctgaaatgcc
     5581 tccaacccga ccgcgaccgc ctgctccagc tcaccggctc gggcggccac ggtgctaagg
     5641 gtgagtctgg cctcagccat ccgcataggt gccttctcgg tgccgtccgc tgcggttccc
     5701 agttcgatga cccgcagagc gtggtgtgcg gccaggtcgt cgcggcgcac cagccggtag
     5761 gcgtccatcg cgtagaagtc ccacttgtcg gggtccacga cgaaatggtg atcgggcctt
     5821 gatgggggct ggtgccggtc caggagttgc cgtccgaccg tcagcgcctg ctcaaccgcg
     5881 gccgggtcgc ccatccgtgc atgtgccttg gccgcttgcc cggccagctg caccgcggcg
     5941 gtgtgttccc cggctgcccc catacccgcg tcggcggcgg tgaccacgtc ccggtagcgt
     6001 ccctgcgtca gcgcgaacca ggaagacatc tcccacgccc acgcggcgat ctcgccatgg
     6061 ccgacctcag tggccaactc caaggcagcc gtccgggtgg cttccgccga ggcgcgcatc
     6121 tgcaggtcgt actcgatgca gccgaccagc aatgccagcc agcctgcagc caccagcaac
     6181 tctcggtgtg cccgaagccc caccgggctg cggagaagtc gatctacctc ccgcagccac
     6241 cgcagccctt ctgcccgtag ctgttgggcg tcctgccagc cgtagtcgca gcacatggcg
     6301 tagacggtgg cgtgtatccc ttccaccaca gcgggcgaca cgtcggaggc gcggaggcgg
     6361 ttcatcagct cggcggtttc ccacagacca gtagccggct cagtctcctc tctttcggag
     6421 acgagtgcca tcagctgtcc ctttgcctcg agggccgagt caagcgcgcg cactgtgctg
     6481 ggggtcggtt gggtcttgcc ggtctccagc tgactaatcg tcgagcggcc cacgtagcta
     6541 gcgttgtaga ggtccctcag cgacatgccg cgttgctgtc gaatctcacg cagcatggct
     6601 gggaatcgag ggtcggtgaa ggtccggcgt ggcatcttgc ctccctgctg acggtcaggg
     6661 cggtggaacc ggccgtccgt caggtccggc cggcccaccg ataagttgac cgtagctgat
     6721 gtcgcccatt gtggccgtca cttgttcaac tgtcgcaacg atggtgtcgg gtcgccccgc
     6781 atgctgcggg ctggcgccgg gtggtgcggt ggtggcgcca tgaagaggtg gtccagagtg
     6841 cgttccgcag tgtccgggat ctgtccgtcg cagcagcgga cagaacacgt ctagcgatca
     6901 gagggttacg gctcgtatgc tttgacgcag gcctatctgg ctgcccagcg ccgaccgcca
     6961 agacaccgcc ccccttgtaa ccaagtccgc ggagcgcagg cgcccaggat cctcccagac
     7021 acgaaagggc gagaccgatc accaccgtca acgaaccatc cacccgtccg ggcggcgacg
     7081 ccgagcggtt gcgtcatgcc atggtcgacg ggattaactc ttggcagccg ctgtcggagc
     7141 cggttgctgc tgcgatgcgt caagtcccgc gacacctgtt cgtccccgac gcctctcttg
     7201 aggaggccta ctccaacagc accgtggtca cgcgccgtga ccaggacggg atcgccacca
     7261 gctcgtcaac cggtcccgga ttgatggggg cgatgctgga ccagctccag ctgcggccgg
     7321 gcatgccggt gctggagatc ggcgccggga ccggctacaa cgccgccctg ctggccgcgt
     7381 tggtcggccc ggccggtcac gtgaccgccg tggagatcac gcccgaggtg gccgacgatg
     7441 ctcgcgcagc cctcaccgcg gctggtgtga ccaacgcgga gattgtctgc ggggatggcg
     7501 agtacggcca ccggccgaac gcgccttatg accggatcat cgccacagcc ggagcgtggg
     7561 agctgcccca atcatgggga gatcagctcg ccgaaggtgg tgtcctggtc gcgccgctgc
     7621 ggatcaaggg gttgacccga tcggtggcgc tgacccgcga cccgtccggg gtgtggcgca
     7681 gccacagcgc cctcaactgc gggttcatgc cgatccgcgg ccgcggcgcg atgcccgaac
     7741 gcaacatccg cctcgcggag gacctgacgg tccgtttcga tgacggccag gacgtggatg
     7801 cggacgagct acggcgggtt gcctctcctc caggcgaggt caggtggtca cgagtcctca
     7861 tagaccgccc gcttgatctg ctggaccttt acctggccga gctggacggt ttctgccgcg
     7921 tgctcgcttc agcatcggtg acagaacgcg gattgatcga accagtggcc ggctggggaa
     7981 gcatgggcgc cgccaccaga caggcgctgg ggtacctgac gaaacgcacc agtctcgata
     8041 atcagtacct ggatgagctg ggcgtttgcg cctacgggcc agccgccgca tcaatgctcg
     8101 accagttgac cgagcgggtt gaccggtgga ggcggacccg cgaagcgatc gccggggtgc
     8161 gcatcgagat ccacccaccc ggccggggcg aggtcgccga cgcgctcatg accgttgaga
     8221 agcggcactc gcgggtcgtt gttcgccctc ggcaggagtc cgagagaagg gccccgcaac
     8281 ctgggtgaga cggacccgta ggttgtcgcc tcgttaagaa ccgggagccc cgatgagtag
     8341 cctcccgcac cttcgaccca atggagcaca gatgagcgca aaccacactc gacagacgga
     8401 ggacttctcc gcactgagag catcgatggt tgacgacctc cgcgaactgg agatggtcac
     8461 caccgaaccg gttgccgcgg cgctgcttgc cgtcccccgg cacctgttcg ccgccggcga
     8521 gccgcccgag acggtgcacg atgtgaacgc cacactggcg ccgaaactcg cgcccgacgg
     8581 tacgaagctc agcgtgatct cggcaccgca catccaggca gcaatgctgg agcaggcgca
     8641 gatcaagcct ggaatgaacg ttcttgaggt cggaagcggc ggctacaacg cggcgttgct
     8701 ggccgaactg gtcggcccaa acggggctgt aaccaccgtt gacattgatc cggagatctg
     8761 cgaactggca cggtcccggc tcgacatcgc cgggtaccgg cacgtgcggg tgctacaagc
     8821 ggacgcggag catggcgtac ccgaacgggc accctacgac cgcatcatcg tcaccgtcgg
     8881 cgcggcggac cttccgccag cctggatcca ccagctgcac ccggaaggca ggatggtggt
     8941 gccactgcaa ttcgccggga tcacccgcct ggtcgccttc gaccacaacg gcgcaggcgg
     9001 gctgattagc cgaagctacc ggctcggcag cttcgtgccg atgcagggcg acggcgccca
     9061 ggatgagcac ctggtaccga tcaacggtgc tgtgacgctc cgggtggacc aggccgcgac
     9121 ggcggaaaca ctcgatgtgg ctgcgctgcg caaggcagtt catacgccga ggatcgcccg
     9181 ctggtccggg accgcattcg acttcccgga cgaactcgac ctgttcctgc tcacctgtga
     9241 gccggagatt ccgatgtatg tgctgtacgc aggcgagagc ctggtggagc aggaggtttt
     9301 cactcccgcg gccctacggg gtgcgcccac gctggtcgat ggtggaagct tcggctaccg
     9361 cagcaagcgc acgaacaacc agatcggggc cgcccccggc tccggcggcg gcaggcgtta
     9421 cgaggagcag accgctgggt tcgaaagcgg agtggtcgcc tacggcccca acgcggagac
     9481 ggtcgcagac cagtacctgc agctgctgcg ccgctgggcg cgagactacc ggcgccgctg
     9541 cgccgcacgc atcgagtatc accccaacag ctcagacgtc ggccacgtca acgggtggcg
     9601 gaccaacaag aagcacggca ccgtcaccgt caactggccc taaccatcta ataacgacgt
     9661 tcgtgatccc gtctgccttg aggaggtagt catgtcgaat gcgctcgacc agacagatac
     9721 cacgaagagt catcccgcca gggacggcga gcaagctgga gccgacgact gggagcttga
     9781 catcaagttc atcgaagcag gcgatgctgt caaacacctc atctacatga ccaacgatca
     9841 gtgcggcacg acctgccagt cggcctgcac taacacctgc ccgtcttagg aaggacgatg
     9901 cgggctgggg tgcctggacg gcggctaccg cccaggcgcc ccagcagggg aaggagcggt
     9961 ggtgtatcgg tacctcgacg cgttggttgt tcgctgcgcg gtgggcccga ctggtcgcca
    10021 gctaccccac tggcctgacc tgaccgggca gcaaggattg acagcgtggc cgcagtggct
    10081 tcggcaggtc ctggcgcagc ccgaattctc agcggcgctg gagcacgcca gcccggtgct
    10141 cgctgctcgg gcacgggcgg tgagtgccgg cggtccgctg tctgaccggg gcacccgccg
    10201 cgtggtgttt tcggtcatgc gttacctgct acgcgccagc ggccgagcga ccccatacgg
    10261 cctgtttgcc ggggtggccc ccggggcggt ggctgccagc ggggtagcgc acgttggcca
    10321 cggtcaccgt gcggttgtgc gtgtgcgtgc cgaatggatg gctgcactga tcgaccggct
    10381 ggaggccgac cctgatctgc agccgctgtt gcgggtgcgc gccaacaacc tgctggccga
    10441 acgcggcggc cggtttgtgc tggcgaaccc ggcggggcaa accccggacc gagtaccgac
    10501 ccagcagctg gtgcgcgcca ctggcccggt ccgggcggcg ttgcagctcg cccacaatcc
    10561 gagggttgtg tatgagctgg tgggcaagct cgttgacgag ttcgaggtgg ccgctaccac
    10621 cgccggagac ctgctggctc agatggttcg gcaccgtctg ctggtgacca gtctgaggcc
    10681 gccgatgacg gtcaccgatc cgctaggttg gatcaccgcc gaggtggaga aactgctggc
    10741 tgacgcggct tcaagcaccg cggcgccggc cagggatctc atggacgggc tgggcactgc
    10801 cgcagaccag gtttcccacc gtgagacgtc ggtgagctgg gcaaattctc ggcggcggca
    10861 ggtcgtcgat gcgctcaaca cggtgaaccc ggccagcgag gcatccgtag cggttgacct
    10921 gcggctggac gccaccgtgg cggtgccgca caccgtgatg gatgaggcag ctcgtgcggc
    10981 ggggctgctg gtccgcctcg cccgccccac cactgccggc tgggttgatt ggcatggccg
    11041 gttcctcgag cgctacggcc ctcgcggggt cgtccccgtt ctgcaggcgg tcgaccccga
    11101 taccggactc ggctacccgg ccggctacca cggcaccccg cccgtgccgg cggccactgt
    11161 gaccgaccgg gaccgcgtcc tgctggcgat cgcacagcag gccgccctca ccggccggca
    11221 cgagatcgag ttggacgaga ccaccatcgg cgaactcgcc ggggcgaagc cggtgacctc
    11281 gatccagccc agcaccgaac tgaccgtcgg catacacgcc cccacgatcc gggcggtgga
    11341 gcagggcgag tttcggctgg cgatcgtggg agtgtcccgc cgagcgggca ccaccacagg
    11401 ccggttcctg gacatgctcg agacgggcga ccgtgagcgg atcgccgacc agtattcggc
    11461 gctgccgacg ctcacccgcg gcgcgctgct ggcacaggtc tcggccgcga ccccgtacac
    11521 ggtcaccgag gacgttgccc gcgccccgca ggtgatgtcg cacctgatcc cggttggcga
    11581 gtaccacgac aaccggggcg acatcatcgc gttggatgac ctcgcggtca ccgccgacga
    11641 gcagcgtctc tacctggtgt cgatgtcgcg ccgtcgggtt gtcgaaccgg tcgtgctcaa
    11701 cgcggtcgag ctggtgcatc acaccctgcc gattgtgcgg ttcctggtcg agatccccac
    11761 cgcagtgtcc accccgtgtg tcgcgttcga ctggggcccg gctgctgcga ggttgccgtt
    11821 cctgcccggg ctgcggcatg ggcgaacgat cctgtccccg gcccggtggc tcctaccggc
    11881 agccgcgctg cccgccccgg gcgggacgtg gcaggagtgg agccgctcgc tggccgcctg
    11941 gcgggcggag acaacctgcc cggccacggt gtacctcggc gacggggacc agcgcatccg
    12001 gctggacctg gccgaaccag cgcaccaggc gctgctacgc gaccacctgg ctcgtcacgg
    12061 caccgcggcg tttcgggccg ccccggccga ggatgctgct gggtggatcg gcgggcgtcc
    12121 gcacgagatc gtcatccccc tggtggttga cgtcgagccg acgccgccgc cgcagcttgc
    12181 ggacccgatc gagccggtga ccgtccgcga ccacgggcat ctgcccggct gcggcggccg
    12241 cgtctacgcc aagctctacg gtcaccccga ccggcagacc accatcctca ccgagtacct
    12301 gccgttgctg ctcgaccagc tcggcggcgg ctgccggtgg tggttcctgc gctatggcga
    12361 cccggaaccc cacctgcgac tacgggtaac cggccctgcc gacccggcca cggtcggggc
    12421 ctgggcgcag cggttgcgcc gcgccggtct cgcgagccgg gtcgtgttcg acaccgacta
    12481 ccccgaaacc gcccggttcg gcggcaccga cgccctcgcc gcagctgagg aggtcttcgc
    12541 cgccgactcc gccgccgcga tcgcccagct gacggccgcc gacaaccggc agggccctga
    12601 tgctgcggcg ttgacggcag cgagcttgct cgacctcatc atcgccttca tcggcgacgg
    12661 taccgaggcg atgcggtggg ctatcgacca cacgcgggcg caccggccgg cgccgccgcg
    12721 agctgtctac gaccaggcag ttctgctggc caacccccac aaccaagccg aactcgccgg
    12781 gtttcccgga ggtgcacgcg ttctggcgag ctggcagcag cggcggcggg cgctgaccgc
    12841 ctaccgcgac aggctgcgga cctgcggcgc cttccctccc gaagtgctgt tgccggatct
    12901 gctgcacctg caccacaccc gaatggcagg ccccgacctg gaagccgaac gccgctgcct
    12961 gcacctggta cgcgccgccg cgctgagctg gaccatccga agcagcaacg gccatgaccc
    13021 cacctaaccc ggccgcgcta gccgcagccg aacaagtcgc cgacgccttc gcccaacccc
    13081 gccacgtccg ctacctcacc accagcggcc gggcacggcc gcagtcgctt gccggcggcg
    13141 cggtcggcat cgccctgcta cacctcgaac gcctatgctc cggccacggc gacgagacca
    13201 ccgcacacac ttggttgtcc cacgccgccg ccgaacccgt gagcgcgggc gacaacgcga
    13261 acctgttcca cggcgccccg gccctcgcgt tcgccctcca cgtcgccgcg gccctcagcg
    13321 gccggtacca ccgcaccctc gcagcactcg acgacaagac cattgccatc acccgaggcc
    13381 gcctggccgc cgcccgctcc cgcatcaacc gcggcgaccg gctcccgatg cgtgagttcg
    13441 accttgtcca cggtctcacc ggactcggcg cctaccacct ggcccaacac cccgaccacc
    13501 ccgtcacccg cgaagtgctc acatacctcg tccggatcac ccagccctcg gcaacggcac
    13561 gcaaacccgg cggcgacgat ctccctgcgt ggtggctggc cagcggcctc aacggcaacc
    13621 cggatccgca ggcgtatccg caggggcacg gcaacctcgg cgtcgcgcac ggcatcagcg
    13681 cggtcgtcgc cctgctctcc ctggcaatcc tgcgtgggct gccggtaccc ggcgctcggc
    13741 aggcgctcgc cgacctgtgc ggttggatcg accggtggtg ccaggacagt gaaaccgccc
    13801 cctggtggcc cggctttgtg acgaccagcc aggtccacgg ctcccagccg ccggcccggc
    13861 cccggccgtc gtggtgctac ggcatcgccg gcaccgcccg cgcgcagcaa ctggccggca
    13921 tggctatggc cgacaccaca cgccagcacc tggccgaggc ggcgatgctg gccacgctgc
    13981 gtgacccgca tcagctggcc cagcttcccg aaatcgggct gtgccacgga aaagctggcc
    14041 tcctccaggc cggatggcgt atggccgccg acgccgaaga ccctcacctc gccaccacac
    14101 tcggcagtct caccgacgaa ctcatcaccc aactgtcggg ccaggtcgac gaccccgacc
    14161 tcatggacgg caccaccggc gccgccttag ccctgcacac catcggcacc ggaaccggcc
    14221 catcctccgg ctgggacaca ttcctcctgc tgacctaaca ccccttcgga gcgaccgtga
    14281 ccccacccct gtggcgccag ttcgacatcg aattccccga ctacagccgc gccgaacccg
    14341 ccgccgtcac ccacctggcc ccgcttctca ccaccaccga agcagacggg ctgatcgacg
    14401 gatggtggtt catccgcaaa cgaccgtgct ggcggatgcg ctacctgccc accgacaacc
    14461 ccccaaccat tcaggaacac cttcgcgccg ctctcggccg cctccagcag gcacaacaca
    14521 tcacccgggc aaccgaggtc atctacgaac ccgaaacccg cgcattcggc ggccctgaag
    14581 cgatggccgt cgcccaccag ctgtggcacc gcgacagccg aaacctactg gcccacctcg
    14641 ccgcaaccac cgacgaaccc gcacgccacc gccgggaact gccgctgctg ctgtacagca
    14701 cgatgctgcg cgccgccggc ctcgactggt acgagcaggg cgacgtctgg gcgagagtcg
    14761 cccgcagccg cccaccggcc gctgtcggcg accgtcccaa cctcacagcg acgatgcgac
    14821 gcctcttgac cgtcgacaca gacgatctca cccgatccag cagggccacc gcagggcttg
    14881 ctgactggac ggccgcctac gccgacgccg gccgcaacct cgcccggctc aacgccggag
    14941 ggttccttga acgcggccta cgccacgttc tcgcccacca catcgtgttc gcattcaacc
    15001 ggatcggcct gcccgccgcc acacaagccg tcctcgccgc aaccgcctcc gaagtgttct
    15061 tcgacgaccc gccgcagcca cagcatcccc ggtcggcttc ggcagggttg tcgtgatcga
    15121 cccaaccggg ccgaccgccc gcaggttccc gatcgtcgcc cggccccggc cggcgtgcca
    15181 acccctaatt cgaagggtcc gcgacctgcg ccaccgagcc gccgccgcgg ttgaccagca
    15241 ggaccgcacc gcggcgaccg tggtgttcaa cctctccgcg cttctagcct cagactgcgg
    15301 gcaaccagcc ctggcgtacc ggtggtgcca acaccttgcc cacatgctgc ttcgccgacc
    15361 gccgcagaat cccaagcaag ccatcgctag cctcgaaccc atcgtgaacc tcgccaggtt
    15421 acgcacccgc gccggcgacg ggcccggcgc atggtcgctg ctggaaaccc tgcaccaagc
    15481 catcaccacc cgcaccgaca tcaacatcga cggcatccac attcccgcag cctgcctcac
    15541 ccggaccccc gacttgcacc gggaactgtc cacctggctt tggacggtgc tgctcgcaga
    15601 cggcggccgt gccctcaccc tggccggccg atgggctgag gcccaccggc ggctcgaaca
    15661 acaccgaggc gtcggaaggc gcatgctcga cggccgccaa atcgctgtcc tcgctcacgc
    15721 ggtcgcaggc gaccacgaca ccgcgctcac acttctggaa gacactgagc gcggggaagc
    15781 ctgggaggcc gcggtcacca cttgcctaac catgctgtgc cgacccagca gcgccggccc
    15841 cgccgatcta cgcactgtca ggcagcagct cgaaccgcca ccggcggaac tggtggtctt
    15901 ccacacccgc ctgggcctgt gcctactcga tgcactgccg tccaacgcac tctcggccgt
    15961 cccctacatc gccgccggcc tgctccgcca tgccgtcacc gacggatatg ccgcacgcga
    16021 cctgctgaac catcctctat gccgcagcat cgccaccggc cagcaacttc aagctctcac
    16081 cgacgtggtg ggtgcatgcg ggctcgacgc cggcgcgatc cccgccgatt cactcggcga
    16141 catcaccgcc gccctcgacc aagcaggaac gctgctggcc ggcccgggtc acggaaacca
    16201 gatagcagcg acgctgccag cgcgcagcgc ccttacaaac cgagccactt cgtgacgact
    16261 gccctggttc cagccggtgt atccaccagc caatgtctgc tccgccgaca gccatcatcc
    16321 agccgaccac ggacggcgtt ccacatcgcc tgtaccgact ccagagaggc caaccttgga
    16381 cgacatcaac tggcagccgc acgcggcgaa cctcgccaag gacctcaccg acataggcgc
    16441 gatccgcgac ccggactggg cggtgacgtt cgccgccacc ccccgacatg tgttcgtacc
    16501 acgcttctac cagatggacg agttcaacca gccccggacg ctcgtcgaca gcgcagactc
    16561 cgttgagcag gatcgcccgc tggagacgat ctacagcgat caggtcctcg tcacccacta
    16621 tcaagtgctt gacgggaaga tgcccgacgg gcaggaaatc cgtaccgcga ccagctccgc
    16681 ctccatgccg agcatcgtcg ccacgatgct cgaccgcctc acagtccagg ttgggcagcg
    16741 ggtgctggag atcggcaccg gcaccggcta caacgccgcg ctgctcgcga accgactcgg
    16801 tgatgaacat gtcacgagca tcgaggttga accagagacc gccgccgagg ccgccgaaca
    16861 cctccacacc gccgggctcc ggccggcgct tgtcgtcggc gacggcgcgg ccggtcaccc
    16921 agcacgggcc ccgtatgacc ggatcattgc cacctgcgct gccgaccgca tcccgtcggc
    16981 gtggatcgac cagctcgccg atggcgggat catcgtcgct ccactcgccg tcggcgggat
    17041 gctggtggtg ctgcataaga ccagcctggg gacggtgtct ggccgggtag atgcgcagcc
    17101 cgtaggtttc atgccgctgc ggccagccgg gcaacacatg cccgacggct gggtcgccga
    17161 catccccaac acgcggctcg agcaccacac aacgacgtgc gttgagcccc aagcctgggc
    17221 cgaccccaac tttcagctgt ggctgggttt acaccggccc gggatgcaga cctcgctctg
    17281 gctggatgat gccggcggct actacgccag cggcgtgtac accgcaaccg gccgggcaac
    17341 agtcgactac accgcaggag ccagcggaga ctggccggtt acgcaggaca gcgagcgggt
    17401 gtgggacacg gtcgaggcag catgggtcac ctggcagcag cacggccgac cggaccgcac
    17461 ccggatcggg atcaccgcac aggtcgacgg cgaccagtac gcgtggatcg acgaccagga
    17521 cggtccgatg cgttggccac tgcccacacc caaaccctgc tacggcacgt aatctcgcta
    17581 gccgagccgc ctacccgggg cgaggtgatc ccgctggacg agaccagtga gccgtgagga
    17641 ggattgcccg cccatgcgaa caccacttgt ccggccaccg gcgctccggc cctgcgaaac
    17701 cgtggcgatc gtatcgacct cgtcgccggt cccggccgac gagcttgccc ggctacgccg
    17761 cccggtactc ctgggtgcgg ccaccgtgat ggatcggatc tttgccgagc taccggccgg
    17821 gaaggcgtag tcactcagtt ggacacgcag ggatgcaagg aggccatatc caccgatggg
    17881 atatggcctc tgaccgaaaa ctatggtggg cgatactggg atcgaaccag tgacctcttc
    17941 cgtgtcaagg aagcgcgctc ccgctgcgcc aatcgcccaa gggatgaacc ctgttaccga
    18001 ggtggggacg ggatttgaac ccgcgtacac ggctttgcag gccgttgcct cgcctctcgg
    18061 ccaccccacc gaggtgaggc ctcggtagcc tcggcagact ctccgagcgg gcgacggggc
    18121 tcgaacccgc gaccttcacc ttggcaaggt gacgcgctac caactgcgct acgcccgcat
    18181 gactccggct gttccccggt gccgagagag aactctagcc cagttccatc cgagacgcca
    18241 acccggggtc gctttcccgg cgtttcctcg cgactccgac gcccgcccca ttcgtcacct
    18301 ccgtgacctg ccgttgccgg accgaggtat ccccctgggc gccgccgttg cgtagggccg
    18361 ccagcctggt cggctggcgg ccctaccgtt ggcgtggagc gtcaggtcag gcggtgaagc
    18421 tcacccgccg gcgccgcgcc accaggaaga gaccgccgcc gagcgccagc agcgccaacg
    18481 cgccgcaacc gctgcgggag cggcggccga tagggtggcg ggatgaacct ggcggagccg
    18541 acgcctgacc ccgggctgat cggggtgacc ggcgccaccg gtggggtcgg gggccgggtg
    18601 gcccgccggt tggccgccgc cggggcccgg cagcggctgg tggtccggga cctgacccgc
    18661 gcccccgacc tgccgggggc cgaggcggtg caggccagct acgaagatct gccggggatg
    18721 cggcaggcgt tggccgaggt cgacaccctg ctgctggtca gcgcgagcga gcacccggac
    18781 cgggtggcgc tgcaccgcac cgcggtcgac gccgcggtcg tcaccggggt gacccgggtg
    18841 gtctaccttt ccttcctcgc cgccgccgcg gacgcgacct tcaccttcgc ccgcgaccac
    18901 tggcataccg agcagtatct gcgcggcacc ggcctgccct gcacctttct gcgcgacagt
    18961 ctttaccagg atgtcctgcc gtacttcccg gaccgggccg gggtgatccg gggcccggcc
    19021 ggggatggcc ggttcgcgcc ggtggcgcgc gacgatgtcg ccgcggtcgc ggcgacggtg
    19081 ctactcgccg gcgacggccg gcacgacggc cagagctatg acctgaccgg gccggagctg
    19141 ctgaccatgg ctgcggtcgc cgcggagctg tcccgggcga ccggccggga catcagctac
    19201 cacccggaga ccctgccgga ggcgtacgag tcacgggccc gcttcggggc accggagtgg
    19261 gaggtgaccg gttgggtcac ctcgtacgcc gcgatcgccg ctggtgagct ggatctgctc
    19321 gccgacgatg tcgcccgggt caccgggcgg ccgccgaccc gcttcgccga ctacctcgcc
    19381 gcgggcgcct gatcggccgg tggcggcgtg gccgggccac cgatccggta gcggcgcccc
    19441 gcctcgaccg tgccccgcca gccacccagc tcgcccggcc gaaggggcac ctgctcaccg
    19501 gtgtcgagcc gccgcagcgg ctgctccggc aggagcgggc agcggatggt cagcgccccg
    19561 gtccggtcgg gcagcaacgt cacctcggtc ggcgcgccgt cgcgccaggc gatgtctaca
    19621 gttaccccac cccgggcgcg gagcccggtg acccgaccgg ccggccacgc cgtcggcagc
    19681 gccggcagga tgtccagcac tccccggtgg ctctgtagca gctgttcggc gacgcccgcc
    19741 accgcgccga ggttgccgtc gagctggtag ggcgggtgga tgtcgaacag gttgggcagg
    19801 gtgcactcgc ggagcagcgc ggtgagcatc cggtgcgccc ggtcgccgtc gcgcaaccgg
    19861 gcccagaagc tgatcttcca ggccttgctc cagccggtcc cgccgtcccc gcgggcgtcg
    19921 agcgacacct ccgccgcccg cgccagctcc ggctcggcca gcggggagat ctggtcggcc
    19981 gggtggagcg cgtaaaggtg ggagacgtgc cgatgctcgt cggccgggtc gtcccggtcg
    20041 gcccgccact cttgcagctg accccaggcg ccgatccgca gacccggcgc cagccggccg
    20101 gcagcgtccg cgaggccggc cggcgggtcg atcgccaact cggcggcggc cgccagcgtg
    20161 gcccggaaca gatcggccac cagctgctgc gacatcgccg ccccggcggt gtacgggccg
    20221 tgttcgggag agtagctggg cgagacgagc agggtgtcgg tggtggcgtc gatgtggagg
    20281 ttggcgagcc agaactccac tgtctcagcc agcaccggcc aggcccggtg ccggaggaac
    20341 tcactgtcgt gagtaaacag atagtgctcc cacaggtgcc ggcacagcca cgcccccgcc
    20401 tccgggaacc agaacgcggt gggccagtcg tggactccgg tgaagcccca cggggtggtc
    20461 tcgtcgtgca ccacccagcc gtcgctgtcg aacatctccc gggcggtgac ccggcccggc
    20521 gcccgcagcg cgtcgatgaa ctcgtgcagc ggcggcgcgg tctccgcgag gttcgtgacc
    20581 tcggccggcc agtaacacat ctgcaggttg atgttgaggt ggtagtcggc gctccaggcg
    20641 ggggtggcgg agtcgttcca caccccctgc aggttcgccg gcagcgagcc gacacgcgac
    20701 gacgagatca acaggtagcg gccgtacgcg aagtggagag cggcgagcgc ccgctcggcc
    20761 gccgggtcgg cggtgtggtc gccgtgccgc cgcaccagct cgtcggtggg caggttgggc
    20821 ggcggcgcgt cgaggtcgag gctgacccgg ccggcgagct gctggtagtc ggcgagatgg
    20881 gcgccgcgca gcgtcgggta cggctgcccg gcggcggcct cgatcgtccg gccgacccgg
    20941 ggggccggat cctcgccccg atagtcgggg taggtggccg cgtagtcggt gccggcggcc
    21001 aaccacagga tcacctcgtc ggctccgctg acccggatct cgcccgccgc ctcggtgacc
    21061 gcgccgccga ccacgtgcag gcgcagctgt gcttcgtacc ggagccggtt gtcggggagt
    21121 tccccccgca gccggatgcc ccgttggccg acggtggtgg cggcgccgag cggccccgcg
    21181 gcgagccgca cggtcagggt caccgaccct ggctggtcgg cccagacccg gccggcgatc
    21241 accccggcgg ggtggctggc gagatactcc cgatggtggg tgaccccatc ggcggtatac
    21301 cggacccggg ccaccgcgtc ggtgaggtcc agctcgcgcc ggtagccggt gacctgcccg
    21361 gccggctcgg ggaagtggag ccacaggtcg gcgaggggct ggtaggcgcc gtagccgagg
    21421 cggggctggc cgagcagttc ggcgacctcg tccggcggga gctcacccac ctcgtcgagg
    21481 cggcggcgga gctcggggag cacccctggc cgcccgggcg gcggccagtc gccgtgctga
    21541 taaccctcgg ccgaaccggg gccgccggtc cacagtgtct tctcgttgag ctgcagccgt
    21601 tcggcagcta cgccaccgaa gaccatcgcg ccgagcgcgc cgttgccgat cggcagcgcc
    21661 tcccgctccc agtcggtggc cggctgctca taccagaggc gcacagtcgc cgaccttatc
    21721 agtccggcgc cgcgagctgc tgctcctgcg caccgccggg agcggtggcg tcgacgaggc
    21781 cgagctccgc caccgcggcc agcccagcct ggtcactgtg gtcggcgaag atctgccggg
    21841 cgtgaccggc cgcgacccgg gcggcctcgg cgtcgctctc ggcgaggcag agccgggcgc
    21901 gggtcaccgc cacgcgggcc tcggcgagcg ggtcgccgag ccggcgcaac gtggccgccg
    21961 cgcgctccac actgacccgc gcctgccccg gcgacccctg ctcgagctgc acatcggcga
    22021 gttcccgcag cgtctcggcc tccccccggg gatcccccag ctgccggtag ccgtcgacac
    22081 tgcgctgcag gaagtcggcc gcttcccaca gttgccgccg gcgccgctgc acctccgcca
    22141 ggcctcgcca ggcatcggcg cagccgcgga ggtcgttgtg gcggacgaag gtctccaccg
    22201 cgccctcgaa gcacacctca gcgccgacca gctcggcggc ggccagctcg gcccacccca
    22261 gccggcaccg ggtgcgcgcc tcctctgccc ggtcgccgag ctcagtcaac cggtgcaggc
    22321 tctcccgcag cgcgtcggcc gcctccggca gccgccgctc gacccggtgc aggtcgccga
    22381 tgccgcgcag catcagcgcc atcccccggc ggtgctccgc cgcccgggca gccgccaacc
    22441 ccagctcatg ggtgcgccgc cactcctcca gctgcgaccg ggaggcgagg tacggcgcca
    22501 ggtagaacgc cagccgccag gccgcctcgt gccaccccgc ctgatgcagg tcggccacgg
    22561 tggccaccag cagcccccgc tctgcggtca gccagtccgc ggcctcccgg atctgccggc
    22621 tgccgacctg cagcgccggt tcggcgagcc gggtggtctc gccgctgccg ggttcggcgg
    22681 gcagcagctg ggcccgggcc cggcgactaa gccgcaacac ccgccgggac aacgcccgcc
    22741 acaacgggtc cgccggctcg tcggtggact gttcccgggc gaacaagcgg gtcaggtcgt
    22801 gacagcggta ccggggctgc ccggccacgt cgaccccgag cggctgcagc agcccggagt
    22861 cgaccagcgt ctccaggatc tgttcggcgc gcgtctcgac ggctggcgtg ggctcggcac
    22921 cggcgagcag gaccgcggcg gtccaggggg cgagatcggg cgcgctgagc agccccagcc
    22981 ggcggaacag ctgctgctcc ggctcggcga gaccgtgata gccgagcgcg atgctgccgc
    23041 ggaccgcgag gtcgccggct gccagctcgt cgagccggcg atgctcatcg gctagccggc
    23101 cggccaggta acccaggctc cagcccgccc ggcgggccag ccgggcaccg gctatccgca
    23161 ccgcgagcgg caggccgccg cagagttcga cgatctgctc ggccgccgcc ggctccgccg
    23221 ccacccgctg cgccccggct acctgcgcca gcagggtcat cgactccttg gtgggcaggg
    23281 tgtccagctg gtaggcggct gcggcggcga gcccggccag gccggaccgg ctggtgatca
    23341 gcgtggcgca gccaggagct gcggccagca gcggccggac ctgggtctcg tcgtgagcct
    23401 ggtccagcag caccagggcc cgacggccat ccagcagggt ccggaacagc tgggcccggt
    23461 cggccaattc gtccggcagg gtggcgtgcg ggccgagcag cgatcgcagc aggctcgcca
    23521 gcgcgctcgc cggcggcagc ggaccgtccc cgcccccgag caggtcgacg tagagcgccc
    23581 cgcccgggaa ccggtcggcg agcgaccggg ccgcccggat cgccacggtg gacttgccga
    23641 caccgccggg accgtgcaac accagatgca ccggcgccgt ttcggccgtg gcgagggccc
    23701 cggccaccca ggccagcgcc tggccccgac ccgtgaagtc gttgatgtcg ggcggaagct
    23761 cccgcggcac ccggagctca ggttgctccg gggccgccgg cgccgcctgc tcgccggtgt
    23821 cggcgagcac ctggtcgtgc gcctgccgca gctccacgcc cggctccaac cccagctcgg
    23881 tgacgagggt ctgccgggcc tgctggtaag tggccaacgc ctcggaacgc cgacccgacc
    23941 ggtgcagggc gatcaccaac tgcgcccacg cccgctcccg cagcggctgc tcggcgacca
    24001 gccggcgcag ctcaccggtg agctcctggt ggcgcccgat ccgcaggtcg aggtcgatcc
    24061 gctcggcgat ggccgcgagc cgcagctcgg tcaggcgcgc cgcatcgccg cggcgcagct
    24121 cgtcggagtc gagatcggcc accggctcgc cgcgccacag cgccagcgcg tcggccagca
    24181 gcgcactcgc cgccgccggc tggtcggggg cgcactggcg cgcctggcct agcagctgtt
    24241 cgaaccgcca cacgtcgacc tgctccgggt cggccagtag ctgatagccg ccgggcaccg
    24301 tcttgatcag atccgcgccg agcagccggc gcagcgcgct gacatacacc cggagcaccg
    24361 actcggccga gcgcggcgga gcgtcgcccc agatcactgc caccagacgc tccacagtcg
    24421 tcagtgaccc gacgttgagc gccagcccgg ccaacaacgc tcggtgcttc gcggggccag
    24481 gggtgaggtc acgctcgccg tcgtgcaccg ccaccggccc caacagggcg atcgagatca
    24541 cgcccgggcc gtttcaccgt gtgtagacac caccgccgaa cgatagaaca caatatctac
    24601 tcgcagccac caccccagcc tggcgggtca gctacccgac actggtgcgc tcaccgtcga
    24661 cgtcagcggg gtgtccccta cgttgcggcc gaccgacaat gtgaactcac ccggctcggt
    24721 cacccaccga tgctgcgcca ctgaccagta gccgaagccg tacgggtcca gcggcacctc
    24781 caccgagacc tgctgacccg gctcggcgtt cgccaccgcg aacccggcga gccagcggac
    24841 cggccgctcc accgaactat ctggacggga cagatacgcc tggacgactt ccttgccggc
    24901 gcgccggccg gtgttgcgca gcgtcaccac cgccgtcgtg cccaccaccc gcaacgactc
    24961 atactcccaa ctggtgtagc ccaggccgta cccgaacggg aaggccggct cgcggccgga
    25021 ccgcagccac gcccgatatc cgatgtggat gccctcgggg tagggcagct gaccctgctc
    25081 cggggtggtg gtcagcaccg gcacatccgc ctcggt
//
