LOCUS       NZ_CP070499            23406 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Natronosporangium hydrolyticum strain DSM 106523 chromosome,
            complete genome.
ACCESSION   NZ_CP070499
VERSION     NZ_CP070499.1
KEYWORDS    RefSeq.
SOURCE      Natronosporangium hydrolyticum
  ORGANISM  Natronosporangium hydrolyticum
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Natronosporangium.
REFERENCE   1  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Natrosporangium hydrolyticum gen. nov., sp. nov, a haloalkaliphilic
            actinobacterium from a soda solonchak soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) Bioinformatics, Leibniz Institute DSMZ,
            Inhoffenstr. 7B, Braunschweig 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-MAY-2020
            Assembly Method                   :: HGAP v. 4
            Assembly Name                     :: 999_Micromonospora_sp_DSM106523
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 580.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016925615.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 06:45:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,188
            CDSs (total)                      :: 5,131
            Genes (coding)                    :: 5,046
            CDSs (with protein)               :: 5,046
            Genes (RNA)                       :: 57
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 85
            CDSs (without protein)            :: 85
            Pseudo Genes (ambiguous residues) :: 0 of 85
            Pseudo Genes (frameshifted)       :: 18 of 85
            Pseudo Genes (incomplete)         :: 72 of 85
            Pseudo Genes (internal stop)      :: 4 of 85
            Pseudo Genes (multiple problems)  :: 8 of 85
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:11:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3030571
            Orig. end                         :: 3053977
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070499.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23406
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="14"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23406
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23406
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13406](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13406)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            168..1721
                     /locus_tag="JQS43_RS13455"
                     /old_locus_tag="JQS43_13395"
     CDS             168..1721
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0009410 - response to xenobiotic stimulus
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00711.1"
                     /locus_tag="JQS43_RS13455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13395"
                     /product="DHA2 family efflux MFS transporter permease
                     subunit"
                     /protein_id="WP_239674734.1"
                     /transl_table=11
                     /translation="MSPPASPAGPVSPLPPRRLIRTVVAGLLTAVFLAALDATVMATAL
                     PTIVGGFGGLDQYAWVVSAYLLTSTAVMPLYGALSDRYGRRAVLRLAVLLFLLGSLLCA
                     GAQEMSQLIAFRGVQGLGAGGLLVLATTIISDLVPPRERARYQGLIGAVFGLASLAGPV
                     LGGVLAEYEWRLIFLLNLPLGLLALLVTERVLRRVPSPPRSARRINYFGALLLVGGVAC
                     LLLTATWGGRTYPWRSTEIVALAGSGVLLLGCWALKERWSREPLLPVSLFGRPTFAIGG
                     LISCCFGAAMFGAITYLPIYLQVVQGHPPIAAGVLLLPLMGGIVLASLIGGRLITRFGR
                     YKWVTVTGATLMSGGTLATLTLRVESAPEQLAGILALLGAGIGLLLQPLIVTMQHGLAR
                     TQLGVATAAGTFLRQLGGVFGVAALGAVLTGWLSQTVGAQVVGLLREPQRIATLPEPLL
                     TEVRVAVVDGLHAAFAVATGFGLLCLLLTLALPDRQIGPRRAEPAPSTPAPAPANTGGN
                     "
     misc_feature    438..440
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1820..2497
                     /locus_tag="JQS43_RS13460"
                     /old_locus_tag="JQS43_13400"
     CDS             1820..2497
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015623150.1"
                     /locus_tag="JQS43_RS13460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13400"
                     /product="response regulator transcription factor"
                     /protein_id="WP_239679430.1"
                     /transl_table=11
                     /translation="MSTAAKPVRVLLADDQPLLRTGFRMVLGGESGLDIVGEASDGAEA
                     VELARRLLPDVVLMDIRMPRLDGVSATRAIVSSRLPVRVLILTTFDLDEYVVGALQAGA
                     SGFLAKDVPAEDLVAAIQTVAAGEAVVAPRILRRLLDRFAAALPEPATETPRGLEILTE
                     REREVLVHIARGESNSEIAQALSVSETTIKTHVGNVLTKLGLRDRVQAVVLAYESGLVR
                     PRQ"
     misc_feature    2432..2434
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2656..3471
                     /locus_tag="JQS43_RS13465"
                     /old_locus_tag="JQS43_13405"
     CDS             2656..3471
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018352629.1"
                     /locus_tag="JQS43_RS13465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13405"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_239674735.1"
                     /transl_table=11
                     /translation="MTKHDTVPAARAEDVWKVYGSGEAQVVALRGVNLNLTKGQFTAIM
                     GPSGSGKSTLMHCLAGLDTVTRGTVYIDQTPLNGLRDNTLTKLRRDQIGFIFQQFNLLP
                     TLTAKENILLPLNIAGRKPDPHWYDTIINTVGLTNRLHHRPTQLSGGQQQRVACARALI
                     TKPHVIFADEPTGNLDSHSGAEILTFLQQSVHQHQQTIVMVTHDPVAAAYADRVIFLAD
                     GNIVDELANPTAEAVLDQLKRLEVAVVNAPAPEQAAGAPAAQRTQVGDA"
     gene            3471..6014
                     /locus_tag="JQS43_RS13470"
                     /old_locus_tag="JQS43_13410"
     CDS             3471..6014
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018800667.1"
                     /locus_tag="JQS43_RS13470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13410"
                     /product="ABC transporter permease"
                     /protein_id="WP_239674736.1"
                     /transl_table=11
                     /translation="MLRATLKSLLSRKLRLMLSGLAVVLGVMFVAGSLVLTDTIGRSFN
                     SMLATAYDEVDVVVTGASSTMPQTGMVETEPIPTEVLDQVQSVAGVGEAVGLITADGAR
                     VVDDRTGQVIGDFGAARLGGNWPDATDSEFMELRDGRGPTAADEIAINQQLADSGDIAV
                     GDRVEVLTLAAGQEFTVVGIWGYSGDRGSLFGETHVAFTTEVAQELMLGIPDVYTDIDV
                     IADGVSPEELRDAISAEIGPEYEVKTGDEAADEQAEQLQEALSFFNYILLGFAGVALFV
                     GVFLILNTFSIIVAQRLRELALLRAIGASRRQMIGSVMLEATVIGAIASLLGLGLGIGV
                     GAGLGWLITSAFGGMPLAGIGIPASAVIGSLTTGMVITLFAALFPALRASRVPPVAAMQ
                     EAGTPDRPLTKLSITGAVITIGGAAALAASLTGNAPLGVLLLGVLLAFVGVALLTPLVA
                     RPVTSLLGRIFAWSTPGDLGRRNTGRNPRRTAITAAALMVGVALVTAISTIFSSLNSSI
                     EQLVADDLQADLVVAGEWLGATPPTFEADVLEQTRQLPEVESVAGFWYDFVEVEGGSGF
                     LLATDDLGAWAAMSNVETVDGSIRALAGGEVAIDDRLAEEQALQVGDTIPITLPRGDGE
                     RQFEVVGVYERNPILQGHIIGAADAEAFRSANPVEAFIQLNPDADADAVRGQVEQLLAG
                     SPEVVVQDQSGYLEQQTQIFDQLLVFIQILLVLAMLIAVLGVINTLVLSVIERTRELGL
                     LRAVGLTRGATARMVTVESVVISLFGALLGIGVGAALGSAVVYALRDEGLNQLTLPTGL
                     MVTYVILGAIVGVIAAIIPAIRAARLNVLNAISYE"
     gene            complement(6041..6859)
                     /locus_tag="JQS43_RS13475"
                     /old_locus_tag="JQS43_13415"
     CDS             complement(6041..6859)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00027.1"
                     /locus_tag="JQS43_RS13475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13415"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_239674737.1"
                     /transl_table=11
                     /translation="MAPRVDPGVQATAFLAAACRAVEQDRPQPRLRDPFAASFVAARGP
                     AQPGYRGLLEAGGDEVVTRTLLVDQLLAAELAGPTAPLVVNLGSGFCARPYRLDLSAAQ
                     LVLELDSPELHRLKSEVLGEAPATCPVRRIGADLRDQSALREVLAAECGAASRVVVVSE
                     GLLPYLPPPALTALAGTLADALPPGTVWLTDVVSADSARQMAALAGGVGARVELHGLVS
                     LDPFTEVGWEPADYRILPVARRGPIGRPGGAGHRSSHQIVDGVLALTRRR"
     gene            complement(6862..7599)
                     /locus_tag="JQS43_RS13480"
                     /old_locus_tag="JQS43_13420"
     CDS             complement(6862..7599)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="JQS43_RS13480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13420"
                     /product="ABC transporter permease"
                     /protein_id="WP_239674738.1"
                     /transl_table=11
                     /translation="MFGKVLSFESRRMLRNVPPLFFALAFPVMILAIFGGIYGNDPSDQ
                     FDGQGTVDVSTPAYVALVLAVAGLMSFPLGMVEYRSRGFLRRLRATPARPIVFLIAQLL
                     VNGLLCLVGIAILLAAGAVFFDLAAPAHPVAFAGLVVLAGAATFGLGMLIASLARSETS
                     AVVLANLVYFPMIFLTGATIPREIMPDTMQQISDLLPLSYAVRALQWAWLDSGGDELPL
                     ALGVLAGTVVASAAVAARLFRWE"
     gene            complement(7589..8542)
                     /locus_tag="JQS43_RS13485"
                     /old_locus_tag="JQS43_13425"
     CDS             complement(7589..8542)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="JQS43_RS13485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13425"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_239674739.1"
                     /transl_table=11
                     /translation="MDGGIEGVGVEVRGLTVRYGSLTAVDGVDLTVAPGEVVGLIGPNG
                     AGKTSLLECVEGLRTAAAGQIRVAGLDPASDRTRLAGLVGVQLQHSAFPSRAKVAEVCS
                     LFASFYPDPADPAELLAQFGLTAAAGQLVSKLSGGQQQRLSLVLALLGRPRLVVLDELT
                     TGLDPAARRSVWEGLRARNDAGLTVLITSHHMDEVEYLCDRVLVLVSGRLVAQGTVSEL
                     ISTHASDVERLVVEDAADQQELRRELAELGPAVRLTPAGNRLRIEVAEPPLREQVTRLL
                     ARYAVTSRSLPASLEDVYLSLTGEQASAKEETSGVR"
     gene            complement(8552..9298)
                     /locus_tag="JQS43_RS13490"
                     /old_locus_tag="JQS43_13430"
     CDS             complement(8552..9298)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="JQS43_RS13490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13430"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_239674740.1"
                     /sec_met_domain="Abi (E-value: 1.1e-07, bitscore: 30.5,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGSAWGFAAVASVAAASWLAVYRLPLARRRTRQRFRLAVSSLTG
                     LDPRYVFPVVGTAIYLVAGLLAITAVTWWSGLDLWAVVSWRPTLVEVALTALVALGAAA
                     STGFAMSLVYAVRPQVDVPGAVAGVGWIREILVLPAHWRWVVPMSSAAVEEFFFRGVFL
                     LGLLASGASVPMAVLLSGAVFILGQVVLTERGLAALVLGVSSVVLSVLCGLLVVVTGSV
                     LPAIVVHASFAGFYTNLGTGRPVRTA"
     gene            complement(9295..10026)
                     /locus_tag="JQS43_RS13495"
                     /old_locus_tag="JQS43_13435"
     CDS             complement(9295..10026)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="JQS43_RS13495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13435"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_239674741.1"
                     /sec_met_domain="Abi (E-value: 6.9e-14, bitscore: 50.3,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSRTLSLSLLVLLCAAFPAQLFRVGLAMTLGPAPGAGKILAQLR
                     RLWLPGAFLLVAGLVWYVAPASGVLAAPVAWWWCAVAVAVGLAAPGVEVGVGAATALAR
                     GRRPVRVRLHERWQRGGAAGGLAVTTALLVAVAEEVIFRGVGLYLLRHELAMPAVLAVA
                     VAALVYALNHLYFGWLTVGQKLVTGVLFGWLFLASGGSVLVPVLAHVAQNVLVVAVLPR
                     WFGGGSAGRPAADQQPQRVPQ"
     gene            complement(10001..11362)
                     /locus_tag="JQS43_RS13500"
                     /old_locus_tag="JQS43_13440"
     CDS             complement(10001..11362)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="JQS43_RS13500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13440"
                     /product="YcaO-like family protein"
                     /protein_id="WP_239674742.1"
                     /sec_met_domain="YcaO (E-value: 2.7e-47, bitscore: 160.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.6e-72, bitscore:
                     242.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRLSHYPSMPHLLRRYQHLAGNQAGILPGYFVAVTDIPGEPLMR
                     AMTATMPAYHRFIMDDPHLQVQYHLSGYGLANEEALVKLMGESVERYAAMAAIRLVDDE
                     FRYATRRELAAEGRCLPLEYLGILDPAQQSALGNRLHRYSDRPPTEDDVIAWVRCPSLL
                     EPGEQLWVPAQLFFLGFTTSVEHRDLLFTPSFSTGTAAHVSLAKALRNALIEAVQIDAF
                     ILNWYTDTPAPAVVIDDDDLLRTFTGMHLGPDSAYTLRANHLTRPELPLPNFGVFLERK
                     TDSLPRLSFGVQGDADPRYAMLRGTMESAAILSLGMYSAIFDTASVHAAVNTSPYLDLD
                     TNVLYYASPQDAARKEEVVAGRFQGSVKLSEIAPLAESDEQALAELLRMVAGVSEWATY
                     LDITPPELADTDWKVVRVLIPEVLSMCLPGLPPKAHPRMVQYGGVTNEFPHPLP"
     gene            complement(11359..12453)
                     /locus_tag="JQS43_RS13505"
                     /old_locus_tag="JQS43_13445"
     CDS             complement(11359..12453)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytolysin_C_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03882.1"
                     /locus_tag="JQS43_RS13505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13445"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_239674743.1"
                     /sec_met_domain="Cytolysin_C_RRE (E-value: 3e-13, bitscore:
                     48.2, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATPHESDPATFALASTARVMEDGSGRFRIRTGVWNFEEAVIDVS
                     AEPPAVAATVQSALRALADGVTILTDHLDPQLLPIERANVERLFADLAQAGVVVAAQDR
                     LDQQAITAALLGRLVSPYPGGGDPPEREVRFWSDSPGAVAQAERLAEDLRLRLVPLPEA
                     TVTQLERADLTSNIEAYQTSNTVAELRGQLAGAAAVVTCFLRPSVPVLRNLNRVLEGQD
                     VPWVSALVDGPFLSAVGVKSPHSGCFECFEQRSLARLEDHVAYHEFTRTAIGAPPPRGS
                     DAPVMHLLASLAVTEGYLHAATGSSRLSGRAVSVHLPTFEIQTQDLLRMPNCPACGRVS
                     KQRLREINFNSRAAVDRIVSAALQ"
     misc_feature    complement(11974..11976)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(12160..12417)
                     /aSDomain="Cytolysin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing discrete C protein in a
                     SLS/cytolysin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JQS43_RS13505_Cytolysin_C_RRE.1"
                     /evalue="1.60E-15"
                     /identifier="RREFam014.1"
                     /label="JQS43_RS13505"
                     /locus_tag="JQS43_RS13505"
                     /protein_end="98"
                     /protein_start="12"
                     /score="48.2"
                     /tool="antismash"
                     /translation="ALASTARVMEDGSGRFRIRTGVWNFEEAVIDVSAEPPAVAATVQS
                     ALRALADGVTILTDHLDPQLLPIERANVERLFADLAQAGVV"
     gene            complement(12456..13406)
                     /locus_tag="JQS43_RS13510"
                     /old_locus_tag="JQS43_13450"
     CDS             complement(12456..13406)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="JQS43_RS13510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13450"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_239674744.1"
                     /sec_met_domain="PF00881 (E-value: 3.8e-21, bitscore: 74.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPYQRTKDEVEAALADHDYLRAVGSFAMQHSLVSIYSTSTVVRTP
                     DTVLRGRWAGAGDDLAGESLLLNYRTDNARHGFQLGIGRFYEPDAVLTSCHADLEEDLR
                     ETVPLPAPKKLRTGLTAAVTTRRSSRELTGEPVSLAELATLLHHAQGNTGELPYGNPAD
                     PHGMIKLRTAPSGGGLYPVTLFVQALNVTGLPAGAYEYFPYSHSLKPVRPPGADPVDPL
                     ALYRSPDLAIDQAAVVFTFVYNLHHNSRKYGDGGVVFGLIEVGAILQNLHLTRTALALA
                     GCDQGGYDKQRIEQALGLDGHTRHVVHVSIIGQEG"
     gene            complement(13858..14532)
                     /locus_tag="JQS43_RS13515"
                     /old_locus_tag="JQS43_13455"
     CDS             complement(13858..14532)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015622894.1"
                     /locus_tag="JQS43_RS13515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13455"
                     /product="response regulator transcription factor"
                     /protein_id="WP_239674745.1"
                     /transl_table=11
                     /translation="MDETNPRTRVLLVDDDALVRTGLKLMLGGAPDLTVVGEVSDGGEV
                     VEAVARLVPDVVLMDIRMPVRDGIDATRALRSESSAPPAVIVLTTFDSDANVLASIRAG
                     AAGFLLKHTSPDEIVAAVRRAAVGEPVLSPDVTRTLMAHVAGSVEPDGRGVRARARLGQ
                     LSEKEREVAVTVARGLSNAEISEQLFMSVGTVKAHVSSALTKLDLANRIQLAVLAHDAG
                     EA"
     gene            complement(14489..15799)
                     /locus_tag="JQS43_RS26060"
                     /old_locus_tag="JQS43_13460"
     CDS             complement(14489..15799)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.4"
                     /locus_tag="JQS43_RS26060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13460"
                     /product="histidine kinase"
                     /protein_id="WP_275580891.1"
                     /transl_table=11
                     /translation="MRQSEGRGVPVWALPGELAAVDGRTSSGRTVRDWLVDTVLFLFAV
                     ALWLNESRSLTTGSADPAYVAAVPDWMLAMDPWVGGLACLSLWWRRRYPLAIAIAMVPV
                     LAVSGAAMGAVLVMIFTVAIHRGWLPAVAVTAPQLVQGLGFALTYQPPGLSLGVYVGWV
                     VGMFGLPLAWGLVVRFRRQVLLGLRREARQERQEQQLRLARARQSERERIAREMHDVLA
                     HRISLLSVHAGALAYRSERAQAGAAQPLSGAEVAEAVRVIRENAHQALTELGEVLTVLR
                     GTEPAATERAEPPPSLGDVAELVAEARAAGQPVTLQLDPSLVTGSLRPQEQRTIYRVVQ
                     EGLTNARKHAPAAPVAVRVGGSPGAEVAVAVSNPVPAGRTAEIPGTGAGLAGLSERVAL
                     DGGTLEHGAMGGIFQLSARLPWHGGRDEPADQGVAGR"
     misc_feature    complement(14543..14545)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15928..16431
                     /locus_tag="JQS43_RS13530"
                     /old_locus_tag="JQS43_13465"
     CDS             15928..16431
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082774.1"
                     /locus_tag="JQS43_RS13530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13465"
                     /product="PH domain-containing protein"
                     /protein_id="WP_239674746.1"
                     /transl_table=11
                     /translation="MKLLAREPIRLRSPAHPVHPRARWWWTLRAVALVVPLLAAAVVAT
                     FVVPGAAWLRPLLPVAGLLAMAYLVVMPLWRYQVHRWEVTEQAVYAATGWVVREWRISP
                     ISRIQTVDTRRGPLEQLLGLAAVAVTTASAHGTVYIVGLDHETAQRTADRLTEITEATP
                     GDAT"
     gene            16428..18065
                     /locus_tag="JQS43_RS13535"
                     /old_locus_tag="JQS43_13470"
     CDS             16428..18065
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015648.4"
                     /locus_tag="JQS43_RS13535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13470"
                     /product="PH domain-containing protein"
                     /protein_id="WP_239674747.1"
                     /transl_table=11
                     /translation="MTSREPAAPAISEVTDPPPRSPSPEPPWRRLDSRMILVDAVQTLL
                     ALTPAVAAVTIFGVEPSLGTLWPALAVAAWGVVSAGTDALRWIKTRYRITDEYVEGRTG
                     LLVRQYRSVRRDRIRSVDTTATLRHRLGGLRVVSIGAGQQANTGEAALALDAISRSDAE
                     RLRRDLLGEAAPAAAATGDQQRPEPPSDPVLAELRWSWIGYNLFSVWAYLAAAGVLWGA
                     MWLGGSVGLDLVGWVTGLLDWRSLGWFWSVMIGFAAISLLGVGVLATGFVTEYWRFRLT
                     RVPRPEGSALRTSQGLFKTRQIDRDEGRIRGIQISEPVLWRWLGVADTNVISTGLNEGG
                     LSPASTILPRGPVTVARRVAAEVLRAAPNPLTAPLRPHPAAAGRRRYWWGIAIAAAVVA
                     AAGIAATTIEPVPNWAPLLASALLPLTLLAAAVAYRALGHTLAGSYLVVRSGLVSRATV
                     ALHGGAIVGWRLRQSLWQRRLGLLSLTATTAAGYGAYEATDLAADDALALADQAAPGLL
                     RPFLLTDHEPGGDRSGDPPPGSKEINDG"
     misc_feature    17550..17552
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18058..18762
                     /locus_tag="JQS43_RS13540"
                     /old_locus_tag="JQS43_13475"
     CDS             18058..18762
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS13540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_13475"
                     /product="hypothetical protein"
                     /protein_id="WP_239674748.1"
                     /transl_table=11
                     /translation="MVEPRRTVVADPSWVSLLFWVGFPVLGGALGAALRWLVPWLLSLP
                     WTPLPGPLRLVENTPSPWGTVVAVALGVLAGLGLAYSAANDQLRVVVTDHQIAVTRAGA
                     TTEFARHRVQGVFRDGKQLVLLGTEAQELAREASDLPEPALRAAFVGHGYRWHADGDPY
                     FDDFRRWVPGLPELPPGADALFTAREKALHDEDYSDARQLRDELDALGVVVRDDQTRQF
                     WRRHRANGAPHD"
     gene            18872..19813
                     /locus_tag="JQS43_RS13545"
                     /old_locus_tag="JQS43_13480"
     CDS             18872..19813
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020524783.1"
                     /locus_tag="JQS43_RS13545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13480"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_239674749.1"
                     /transl_table=11
                     /translation="MTEPVLECKHLRKAYGQLTAVDDISFSIREGETYGLLGPNGAGKT
                     TTISMVVGILARDGGEVTVAGQPHGVNRTATKAMIGYVPQDLALYPDLTALENLRFFGN
                     LYGLHGGAQKRRVAEVVELVGLSDRASDRVDKFSGGMARRLHIAVGLLNQPRLLILDEP
                     TAGVDPQSRNAILASVQQLAEEGLAVLYTTHYMEEAERLCDRVGIIDEGQLKAEGTRRE
                     LVRLVGSQDEIVLTTEGDPAAAADALGKLPEVGTLTREESRIRLMVGEAAPLLPTVLAA
                     ATGTGTTVRSVEVRQPNLEAVFLHLTGKALRD"
     gene            19821..20987
                     /locus_tag="JQS43_RS13550"
                     /old_locus_tag="JQS43_13485"
     CDS             19821..20987
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024091.4"
                     /locus_tag="JQS43_RS13550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13485"
                     /product="ABC transporter permease"
                     /protein_id="WP_239674750.1"
                     /transl_table=11
                     /translation="MRTIIHLTAKDLRQQLRNGTLLLFAVVLPLGLAFMFNSLMAPGDP
                     QLNVSYGVVDEDGGELATVFTNEVLTAIATDSSFEIEPVTDRETAHRLLDDQDQDAVFI
                     LPAGFTDQVNAGQEARIDVIGHPDAGIAVQIAREIAQAFAAELRGVQLAVAVGGADDPD
                     ADPAHLAEQAAELAAPVVLAVDDSVDDRELSSNTHYSAGMAVFFLFFTAMLSVSGLLEE
                     RSQGTMARLLAAPSGRPAILAGKLLSSVVVGVAAMTVLIGASTLLLGASWGDLRGVAVL
                     VVAVVLAAVAIMALLCSFANTAEQASNWMSVLAVLFGLFGGSFVPLAQFGGLAVISYAT
                     PHRWFLQGLSELTGAGPAAAIVPALVLTGIAAVAFAVTLLRIDKVVRA"
     gene            20984..22144
                     /locus_tag="JQS43_RS13555"
                     /old_locus_tag="JQS43_13490"
     CDS             20984..22144
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024110.4"
                     /locus_tag="JQS43_RS13555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13490"
                     /product="ABC transporter permease"
                     /protein_id="WP_239674751.1"
                     /transl_table=11
                     /translation="MKMLAIAGLNLRRLFRYRPNVFFVIIGPLLFLLVLGMLFGGSQPV
                     RIGVVDGGGPLAERLTDALAEDDRVELTRFDDHAELQTELERGLLNAGVVIPDDYDQVV
                     GDGEQAAVRYLARADDPLAADLGVWVRSVIPQEAALLRAAQFGAQEHGAPVDQHLRAAE
                     SAAATMPGIEVAVTTTGEAQIPEGLSQFAPMAPSLLLLFVFFTSLMAALGLVEARRLGV
                     ITRMTATPTPIRTLVAGEALGRFAVALTQGLIVLLGSALLFGVDWGDPIGAAAVLVLFC
                     LVGSGAAMLLGALFRNEGAAMGVGMGLGLGLAALGGTMLPLELLSDQVQTIAKATPHAW
                     GYEAYSELVRHGGTVTDILPQLGALAGFAAVLFTLGAWQLQRSLTR"
     misc_feature    22340..22351
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            22344..23144
                     /locus_tag="JQS43_RS13560"
                     /old_locus_tag="JQS43_13495"
     CDS             22344..23144
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011906114.1"
                     /locus_tag="JQS43_RS13560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_13495"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_239674752.1"
                     /transl_table=11
                     /translation="MNAAQRTAHNRAGGGAFAARAEDVWKVYGSGEAQVVALRGVNLNL
                     TKGQFTAIMGPSGSGKSTLMHCLAGLDTVTRGTVYIDQTPLNGLRDNTLTKLRRDQIGF
                     IFQQFNLLPTLTAKENILLPLNIAGRKPDPHWYDTIINTVGLTNRLHHRPTQLSGGQQQ
                     RVACARALITKPHVIFADEPTGNLDSHSGAEILTFLQQSVHQHQQTIVMVTHDPVAAAY
                     ADRVIFLADGNIVDELANPTAEAVLDTMKRLDTLVATDAAEAVA"
ORIGIN
        1 ccgctgttgc cggactgagc ggcggctcag ctcacccaac gggcgccgcc cccggccact
       61 cccaccacac accgggctaa atgtcggctt tgcccataac tcaccccggc ctggcgggtt
      121 tcccactggg gcgctccagc gcgcctagct cgatcgggag gagtgacatg tctccgccag
      181 cctcgcccgc cgggccggtg tcgcccctgc caccgcgccg gctgatccgc accgtggtcg
      241 ccggcctgtt gaccgcagtg ttcctcgccg cgctcgacgc caccgtgatg gcgaccgcgc
      301 tgccgacgat cgtgggaggt ttcggcgggc tcgaccagta cgcctgggtg gtcagcgcct
      361 acctgctgac ctcaacggcg gtgatgccgc tctacggcgc gctcagcgac cggtacggac
      421 ggcgggcggt gctgcggtta gcggtgctgc tgttcctgct cggttcgttg ctgtgcgcgg
      481 gcgcccagga gatgtcgcag ctgatcgcct tccggggcgt ccagggcctc ggagccggcg
      541 ggctgctggt cctggcgacc acgatcatct cggacctggt cccgccccgg gaacgggctc
      601 gctatcaggg actgatcggt gcggtcttcg ggctggccag cctcgccggc ccggttctcg
      661 gcggggtgct ggccgagtac gaatggcggc tgattttcct gctcaacctg ccgctgggac
      721 tgctggcgct actggtgacc gagcgggtgc tccgtcgggt cccgagcccg ccccgctccg
      781 cccggcggat caactacttc ggtgcgctgc tgctggtggg cggggtggca tgcctgctgt
      841 tgaccgccac ctggggaggc cgcacgtacc cgtggcgctc gaccgagatc gtcgcgctgg
      901 ccggcagcgg cgtcctactc ctcggctgct gggcgctcaa ggaacggtgg tcgcgggagc
      961 cgctgctacc agtgtcgctg ttcggtcggc ctaccttcgc gatcggcggg ctgatcagct
     1021 gctgcttcgg cgcggccatg ttcggggcca tcacctacct cccgatctac ctgcaggtgg
     1081 tgcagggcca cccgccgatc gccgctggcg tgctgctgct gccgttgatg ggcgggatcg
     1141 tgctcgcctc gctgatcggc ggacggttga tcacacggtt cgggcggtac aagtgggtca
     1201 cggttaccgg cgcgacgctg atgagcggcg gcacgctcgc cacgctcacg ctgcgggtgg
     1261 agagtgcgcc ggagcagctg gcaggcatcc tggcgctgct gggcgcagga atcggcctac
     1321 tgctgcagcc gttgatcgtc accatgcagc acgggctggc ccggacccaa ctcggagtcg
     1381 ccaccgccgc cggcaccttc ctccggcagt tgggcggggt cttcggcgtc gccgcgctcg
     1441 gcgccgtgct gaccgggtgg ttgtcccaga cggtcggggc gcaggtcgtg gggcttctcc
     1501 gggagccaca gcggatcgcc acgcttccgg aaccgctgct gaccgaggtc cgggtggcgg
     1561 tggtcgacgg gctccacgcg gcgttcgcgg tggccaccgg attcgggctg ctctgcctgc
     1621 tcctgaccct ggcgctcccg gaccggcaga tcggcccccg gcgggcggag ccggcaccgt
     1681 cgacccccgc gccagcgccc gccaacaccg gcgggaactg agcggccacc cggccgcgcg
     1741 gatggttgcc ggcatgggcg aagatttccc ggcgggccct tcccgcgcca tcgaccacga
     1801 ccgacgggac accgaccaga tgagcaccgc cgcgaagccc gtccgcgtcc tgctcgcgga
     1861 cgaccagccg ctgctccgca ccggcttccg gatggtgctc ggcggagagt ccggcctcga
     1921 catcgtgggt gaggccagcg acggtgcgga ggcggtcgaa ctcgcccggc ggctgctgcc
     1981 cgacgtcgtg ttgatggata tccggatgcc ccggttggat ggcgtctccg cgacccgggc
     2041 gatcgtcagc tcccggctgc cggtacgggt tctgatcttg accaccttcg atctggacga
     2101 gtatgtcgtc ggcgcactcc aggccggtgc gagtggtttc ctcgccaagg acgtgcccgc
     2161 cgaagacctg gtcgcggcga tccagacggt cgcggccggg gaggcggtgg tcgcgcctcg
     2221 gatcctgcgg cggttgttgg accggttcgc ggccgcgcta ccggagccgg ccaccgagac
     2281 cccccgcggg ctggagattc tcaccgagcg ggagcgggaa gtgctggtcc acatcgctcg
     2341 cggtgaatcg aacagcgaga tcgcacaggc actatcggtg agcgagacca ccatcaagac
     2401 ccacgtcggt aacgtgctga ccaaattggg gttacgggat cgggtccaag cggtggtgct
     2461 ggcttacgaa tcggggctgg tccgcccgcg gcaatgaccc gacgaccgcc ggaactgtcc
     2521 ttccccagac ggacacctcc tcctaccgga ggagacgaag tgactccgaa agcaggagcg
     2581 cgcagtggcg tagagggtct agggttgcgc tggcttacga cagttggacg ggatccgaac
     2641 ggagcagtag cgcagatgac caagcatgac accgtgccgg cggctcgggc agaggacgta
     2701 tggaaggtct acgggtcagg tgaagcccag gtcgtcgccc tccgcggcgt caacctcaac
     2761 ctcaccaaag gccagttcac cgccatcatg ggcccctccg gctccggcaa atccaccctc
     2821 atgcactgcc tcgccggcct cgacaccgtc acccgcggca ccgtctacat cgaccaaacc
     2881 ccactcaacg gcctccgcga caacaccctc accaaactcc gccgcgacca aatcggcttc
     2941 atcttccaac aattcaacct cctccccacc ctcaccgcca aagaaaacat cctcctcccc
     3001 ctcaacatcg ccggccgcaa acccgacccc cactggtacg acaccatcat caacaccgtc
     3061 ggcctcacca accgcctcca ccaccgaccc acccaactat ccggcggcca acaacaacgc
     3121 gtcgcctgcg cccgcgccct catcaccaaa ccccacgtca tcttcgccga cgaacccacc
     3181 ggcaacctcg acagccacag cggcgccgaa atcctcacct tcctccaaca aagcgtccac
     3241 caacaccaac aaaccatcgt catggtcacc cacgaccccg tcgccgccgc ctacgccgac
     3301 cgcgtcatct tcctcgccga cggcaacatc gtcgacgaac tcgccaaccc caccgccgaa
     3361 gccgtcctgg atcaactgaa gcgactcgag gtggccgtgg tcaacgcgcc agcgcccgag
     3421 caggctgctg gagcaccggc ggcgcagcgc acccaggtgg gagacgcctg atgctgcgcg
     3481 ccaccctgaa gagcctgctc tcccgcaaac tgcggttgat gctctccggg ctcgccgtcg
     3541 tgctcggggt catgttcgtc gccggcagcc tggtcctcac cgacaccatc ggccgctcat
     3601 tcaacagcat gctcgccacc gcgtacgacg aggtcgatgt cgtggtcacc ggcgcgtcga
     3661 gcaccatgcc gcagaccggc atggtcgaga ccgagccgat cccgaccgaa gttttggatc
     3721 aggtgcagtc ggtggccggg gtcggtgagg cggtcggcct gatcaccgcc gacggggccc
     3781 gggtcgtcga tgaccgcacc gggcaggtga tcggcgactt tggtgcggcc cgcctcggcg
     3841 gcaactggcc ggacgctacc gacagcgagt tcatggagct ccgggacggc cggggcccca
     3901 ccgccgccga cgagatcgcg atcaaccaac agctcgccga ttcgggcgat atcgcggtcg
     3961 gagaccgggt cgaggtgctc accttggcgg ccggccaaga gttcaccgtg gtgggcatct
     4021 ggggctacag cggtgaccgg ggctcactgt tcggcgagac ccatgtcgcc ttcaccaccg
     4081 aggtcgcaca agagctgatg ctcggcattc cggacgtcta caccgacatc gacgtgatcg
     4141 ccgacggcgt atccccggaa gagctacgcg acgccatctc cgccgagatc ggcccggagt
     4201 acgaagtaaa gacaggcgac gaggcagccg acgaacaagc cgaacaactt caagaggcgc
     4261 tgtcgttctt caactacatt ctgctcggct tcgcgggggt ggcgctgttc gtcggcgtct
     4321 tcctgatcct caacaccttc tcgatcatcg tcgcgcagcg gctgcgcgag ctggcactgc
     4381 tccgggcgat cggcgccagt cgccggcaga tgatcgggtc ggtgatgctg gaggccaccg
     4441 tgatcggcgc gatcgcgtcg ctgctcggcc tggggctcgg catcggcgtc ggcgcggggc
     4501 tcggctggct catcaccagt gccttcggcg ggatgccgct ggccgggatc ggcatccccg
     4561 ccagcgccgt catcggctcg ctcaccaccg gtatggtgat cacgctgttc gcggcgctct
     4621 tcccggcgct gcgcgcctcc cgggtgccgc cggtcgcggc catgcaggaa gccggcacac
     4681 cggaccggcc gctgaccaag ctcagcatca ccggggcggt catcaccatc ggcggcgcgg
     4741 cggcgttggc cgcctccctc accggcaacg cccccctcgg cgtcctgctc ctgggggtgc
     4801 tcctcgcctt cgtcggcgtc gcgttgctga ccccgctggt ggcccggccg gtcacctcgc
     4861 tactcgggcg catcttcgcc tggtccacac cgggcgatct cggccgtcgc aacaccgggc
     4921 ggaacccgcg ccgcaccgcc atcaccgccg ccgcattgat ggtcggggtg gcgctggtca
     4981 ccgcgatcag caccatcttc agctccctca actccagcat cgaacagctg gtcgcggacg
     5041 acctccaggc cgacctggtg gtcgccggcg agtggctggg cgccactccc cccaccttcg
     5101 aagctgacgt gctggagcag acccggcagc tgccggaggt cgagtcggtc gccgggttct
     5161 ggtacgactt cgtcgaggtc gagggcggca gcggattctt gctggccacc gacgatctgg
     5221 gcgcctgggc cgcgatgtcg aacgtcgaga ctgtggacgg ctcgatccgg gcgctggccg
     5281 gcggcgaggt agccatcgac gaccggctcg ccgaggagca ggcgctccag gtcggggaca
     5341 cgatcccgat cacgttgccc cgcggcgacg gagaacgcca gttcgaggtg gtcggcgtct
     5401 acgagcgcaa cccgatcctg cagggtcaca tcatcggcgc cgcggacgcg gaagctttcc
     5461 ggtccgccaa tccggtcgag gcgttcattc agttgaatcc cgacgccgac gccgacgccg
     5521 tccgcgggca ggtggagcag ctcctcgcgg gcagccccga agtggtggtc caggatcaga
     5581 gcggttatct ggagcagcag acacagatct tcgatcaact gctggtcttc atccagatcc
     5641 tgctcgtgtt ggcgatgctc atcgcagtcc tcggagtgat caacaccctg gtgctgtcgg
     5701 tgatcgaacg tacccgggag ctcggtctgc tgcgggcggt cggattgacc cgtggcgcca
     5761 ccgcgcgaat ggtcaccgtc gagtcggtgg tgatctcact cttcggcgcc ctgctcggca
     5821 tcggagtcgg cgcggccctc gggtcggcgg tggtctatgc cctccgcgat gagggtctca
     5881 accagctgac gctgcccacc ggcctgatgg tcacctacgt gatcctcggg gcgatcgtcg
     5941 gcgtgatcgc ggcgatcatt ccggcgatcc gggccgcccg gctgaatgtg ttgaacgcta
     6001 tctcctacga gtgacctcgc cgctgacgcg gcggcggtga ctaccgccgc cgcgtcagcg
     6061 caaggacgcc atcgacgatt tggtgactgc tgcggtgccc ggccccacca gggcgaccaa
     6121 tcgggccccg cctcgccacc ggcaagatcc ggtagtcggc cggctcccag ccaacctccg
     6181 tgaacgggtc caggctgacc agaccgtgca gctccacccg cgcgcccacc ccgccggcca
     6241 gggccgccat ctgccgagcg gaatcggccg agaccacatc ggtcagccag accgtccccg
     6301 gggggagggc atcggcgagc gtaccggcga gggccgtcaa cgccggcggc ggtaggtacg
     6361 gcagcagccc ttcactcacc accaccaccc gcgacgcggc accgcactcg gccgccagca
     6421 cctcccgcaa cgccgactga tcccgcaggt cggcgccgat ccgccggacc gggcaggtcg
     6481 ctggcgcctc ccccagcacc tcggacttga gccggtgcag ctcgggtgag tccagctcca
     6541 gcacgagctg ggcggcggag aggtcgagcc ggtacgggcg ggcgcagaac ccagaaccca
     6601 gattcaccac cagcggcgcc gtcggcccgg ccaactcggc ggcgagtagc tgatccacga
     6661 gcagcgtacg ggtcaccacc tcgtcgccgc cggcctcgag caaccctcgg tagccgggct
     6721 gcgccgggcc gcgggccgcg acgaagctcg ccgcgaacgg gtcccgcagc cgcggctgcg
     6781 gccggtcctg ctccaccgcg cggcacgcgg cggccagaaa cgcggtcgcc tgaactcctg
     6841 ggtccacccg cggcgccacg cctactccca ccggaacagc cgggcggcca ctgccgcgct
     6901 ggccaccacg gtgccggcga gcacccccaa tgccagcggc agttcgtcgc cgcccgagtc
     6961 caaccaggcc cactgcagcg cccgaaccgc gtacgacaat ggcaacaggt cgctgatctg
     7021 ctgcatcgtg tcgggcatga tctcccgtgg gatggtggca ccggtcagga agatcatcgg
     7081 gaagtagacc aggttggcca gcaccaccgc cgacgtttcg ctccgcgcca gcgacgcgat
     7141 cagcatgccg aggccgaagg tcgcggcacc ggcaagcacc accagcccgg cgaacgcgac
     7201 cgggtgcgcc ggcgccgcca agtcgaagaa gaccgccccg gcggcgagca gaatggcgat
     7261 tcccaccaga catagcaacc cgttgaccag cagttgggcg atgaggaaga cgatcggacg
     7321 cgccggagtg gcgcgcaacc ggcgcaggaa tccccgggac cggtactcca ccatccccag
     7381 cgggaagctc atcaacccgg cgacggcgag taccagcgcc acgtaggccg gtgtcgaaac
     7441 atccacagtg ccctggccgt cgaactggtc ggacggatcg ttaccgtaga tgccgccgaa
     7501 gatggcgagg atcatcaccg ggaacgccag cgcgaagaag agcggcggca cgttccgcag
     7561 catccgccgg ctctcgaagc tgagcacctt accgaacacc gctcgtctcc tccttcgcgc
     7621 tggcctgctc accggtcagg ctcaggtaga cgtcctccag cgacgccggc agcgacctgc
     7681 tggtcaccgc atatcgcgcc agcagccggg tgacctgttc ccgcagcggc ggctccgcca
     7741 cctcgatccg cagccggttg ccggccgggg tgagccggac cgccggcccc agctcggcca
     7801 gctcccgccg gagttcttgc tggtcggccg cgtcctccac caccaaccgc tcgacgtcgc
     7861 tggcgtgggt ggagatcagc tcgctcaccg tgccctgcgc caccagccgg cccgagacca
     7921 gcaccagcac ccggtcacag aggtactcga cttcatccat gtgatggctg gtgatcagca
     7981 cggtcagtcc ggcgtcgttg cgtgcccgca acccttccca caccgaccgc cgcgccgccg
     8041 ggtccaggcc agtggtcagt tcgtcgagca ccaccagccg gggccgaccg agcagcgcca
     8101 gcaccagcga cagccgctgc tgctgccctc cggagagctt gctgaccagc tgccccgctg
     8161 ccgcggtgag gccgaactgg gccagcaact cggccgggtc ggccgggtcg gggtagaagc
     8221 tcgcgaacaa ggagcagacc tccgccacct tggcccgcga cgggaacgcg gagtgctgga
     8281 gctggacgcc gaccagacca gccagccggg tccggtcgga cgccgggtcg aggccggcca
     8341 cccggatctg ccccgcggcg gcggtgcgca gcccttccac acactccagc agcgaggtct
     8401 tgccggcgcc gttcggcccg atgagcccca ccacctcccc cggggcgacg gtcagatcta
     8461 ccccgtcgac cgcggtcagg ctgccatacc ggacggtcag cccacgtacc tcgacgccga
     8521 cgccctcgat gccaccgtcc atcatgtctc cttacgctgt ccggaccggc cggccggtac
     8581 ccaggttcgt gtagaagccg gcgaacgatg cgtgcaccac gatcgccgga agaacgctgc
     8641 cggtcaccac caccaacagc ccgcacagca ccgagagcac cacgctggag acccccaaca
     8701 ccagcgcggc caggccgcgc tcggtcagca ccacctggcc gaggatgaag accgcgccgc
     8761 tgagcagcac cgccatcggc accgaagccc cggatgccaa cagcccgagc aggaacacgc
     8821 cgcggaagaa gaactcctcc accgccgcgc tgctcatcgg gaccacccac cgccagtgcg
     8881 cgggcagcac caggatctcc cggatccacc ccacgcccgc caccgcgccc ggcacatcca
     8941 cctgcggccg caccgcgtac accagcgaca tcgcgaagcc ggtgctggcc gccgcgccca
     9001 gcgccaccaa cgcggtgagc gccacctcaa ccagggtcgg ccgccagctc accaccgccc
     9061 acaggtcgag ccccgaccac caggtcaccg ccgtgatcgc cagcaggccc gcgaccaggt
     9121 agatcgcggt gccgaccacc gggaagacgt agcgcgggtc gagccccgta agcgaggaga
     9181 ccgcgagccg gaaccgctgc cgggtccgcc gccgggccag cggcagccgg tagaccgcca
     9241 gccagctcgc ggcggccacg ctcgcgaccg cggcgaaccc ccaggcggag ccggtcactg
     9301 cggcacccgc tgcggctgct ggtccgccgc cgggcgaccg gccgacccgc cgccgaacca
     9361 ccgcggcaag accgccacca ccagcacatt ctgggccacg tgggcgagca ccggcaccag
     9421 cacactgccg ccgctggcga gaaacagcca gccgaagagc accccggtga ccagcttctg
     9481 acccaccgta agccagccga agtagaggtg gttgagcgcg tagaccagcg ccgccaccgc
     9541 caccgccagc acggccggca tcgccaactc atgccgcagc aggtacaggc ccaccccgcg
     9601 gaagatcacc tcctccgcga cggcgaccag tagcgcggtc gtcaccgcca gcccgccggc
     9661 ggcaccgccg cgctgccacc gctcgtgcag ccgcacccgc accggccggc ggcctcgggc
     9721 cagcgccgtc gccgcgccca cgcctacctc taccccggga gcggccagcc cgaccgccac
     9781 cgcaaccgcg caccaccacc acgccaccgg ggcggccagc accccgctgg ccggcgccac
     9841 gtaccagacc agcccggcga cgagcaggaa cgctccgggt agccagagtc gccgcagctg
     9901 cgcgaggatc ttcccggctc cgggggcggg gccgagcgtc atcgccaggc ctacccgaaa
     9961 cagttgcgcc gggaaggcag cgcagagcag caccagcaga ctaagggaga gggtgcggga
    10021 actcattggt cactccgccg tactgcacca tccgcgggtg ggccttcggc ggtaggccgg
    10081 gcaggcacat gctcagcacc tccgggatga gcacccgcac caccttccag tcggtgtcgg
    10141 ccagctccgg cggggtgatg tccaggtagg tcgcccactc actgaccccg gcgaccatcc
    10201 ggagcagctc cgccagcgcc tgctcatccg attcggccag cggggcgatc tcggacagct
    10261 tcaccgagcc ctggaaccgg cccgccacga cttcttcctt ccgggccgcg tcctgcggac
    10321 tggcgtagta gaggacgttg gtgtccagat ccaggtaggg cgaggtgttg accgcggcgt
    10381 ggacactcgc ggtgtcgaag atcgcgctgt acatgccgag gctcaggatc gccgcgctct
    10441 ccatggtgcc ccgcagcatc gcgtaccgcg ggtccgcgtc gccctgcact ccgaagctga
    10501 gccggggcag cgagtcggtc ttccgttcca ggaagacgcc gaagttcggc agcggcagct
    10561 ccggccgggt gaggtgattg gcccgcaggg tgtaggcgga gtccggcccc aggtgcatgc
    10621 cggtgaaggt ccgcaacagg tcgtcgtcgt cgatcaccac tgccggggct ggggtgtcgg
    10681 tgtaccagtt gaggatgaac gcgtcgatct ggaccgcctc gatcagcgcg ttgcgcagcg
    10741 ccttggccag cgagacgtgg gcggcggtgc cggtggagaa cgacggggtg aagagcaggt
    10801 cgcggtgctc gacgctggtg gtgaatccga ggaagaacaa ctgcgccggc acccacagct
    10861 gttcgcccgg ctccagcagc gaagggcagc gtacccacgc gatcacgtcg tcctcggtgg
    10921 gcggccggtc gctgtagcgg tgcagccggt tgcccagcgc ggattgttgg gcaggatcga
    10981 gaatgccgag atactccagc ggcaggcagc gaccctcggc ggcgagctcc cgccgggtgg
    11041 cgtaccggaa ctcgtcgtcg accagccgga tcgccgccat cgcggcgtac cgctcgacgc
    11101 tctcgcccat cagcttgacc agcgcttctt cgttggccag gccgtagcca ctgaggtggt
    11161 actgcacctg caggtgtggg tcgtccatga tgaaccggtg gtaagccggc atggtggcgg
    11221 tcatggcccg catcaacggc tcgcccggga tgtcggtgac cgccacgaag tatcccggca
    11281 ggatgccggc ctggttaccg gcgaggtgct ggtaccgccg caacaggtgc ggcatcgagg
    11341 ggtagtggga cagccgggtc attgcagcgc cgccgagacg atccggtcca ccgcggcccg
    11401 gctgttgaag ttgatctcac gcagtcgctg cttggagacc cgcccgcagg ctggacagtt
    11461 cggcattcgc agcaggtcct gggtctggat ctcgaaggtc ggtaggtgca cgctgaccgc
    11521 ccgcccagac agccgggacg agccggtggc cgcatgcaga tagccttcgg tcaccgccaa
    11581 gctcgccagc aggtgcatga ccggcgcgtc actgcctcgc ggcggcggcg ccccgatcgc
    11641 ggtacgggtg aactcgtggt aggcgacgtg gtcctcgagc ctggccaacg accgctgctc
    11701 gaagcactcg aagcagccgg agtgcggtga cttcacaccg accgccgaga ggaacgggcc
    11761 gtccacaagg gcgctgaccc acggcacgtc ctgcccctcc aacacccggt tgaggttgcg
    11821 cagcaccggc acgctggggc gcaggaaaca ggtcaccact gcggccgcgc cagcgagctg
    11881 gccccgcagc tcggcgacgg tgttactggt ctggtaagcc tcgatgttgg aggtcagatc
    11941 ggcgcgctcc agctgggtca ccgtggcctc gggtaacggc accaaccgca gccggagatc
    12001 ttcggcgagc cgctcggcct gggccaccgc gcccgggctg tccgaccaga accgcacctc
    12061 ccgctccggc gggtcgccgc cgcccgggta cggcgagacc agccggccca gcagcgcggc
    12121 ggtgatcgcc tgctggtcga gccggtcctg ggcggcgacc accaccccgg cctgggcgag
    12181 gtcggcgaag agtcgctcga cgttggcgcg ttcgatcggc aacaactgcg ggtccaggtg
    12241 gtcggtcagg atcgtgaccc cgtcggcgag cgcccgcagc gccgactgca cagtggccgc
    12301 gaccgccggc ggctcggcgc tgacgtcgat gacggcttct tcgaagttcc agaccccagt
    12361 gcggatccgg aaccggccgc tgccgtcctc catcacccgc gcggtgctgg ccagcgcgaa
    12421 cgtcgccgga tccgattcgt gtggtgtcgc caccgtcatc cctcctgacc gatgatgctg
    12481 acgtggacga cgtgccgggt gtgcccgtcg agccccagcg cctgttcgat ccgttgtttg
    12541 tcgtagccac cctggtcgca cccggccagc gccagggcgg tccgggtgag gtgcaggttc
    12601 tgcaggatcg ccccgacctc gatcagcccg aacaccaccc cgccgtcgcc gtacttgcga
    12661 gagttgtggt gcaggttgta gacgaaggtg aacaccaccg ccgcctggtc gatcgccagg
    12721 tccggcgaac gatagagcgc cagcgggtcg accggatcgg ccccgggtgg tcggaccggc
    12781 ttgagtgagt gggagtaggg gaagtattcg taggccccgg cgggcagacc ggtcacgttg
    12841 agcgcctgga cgaacagggt gaccgggtag aggccgccgc cggagggggc ggtacgaagt
    12901 ttgatcatgc cgtgcgggtc ggcggggttg ccgtagggca gttcgccggt gttgccctgg
    12961 gcgtggtgga gcagggtcgc cagctcggcc aggctcaccg gctcaccggt gagttcccgg
    13021 ctgctgcgcc gggtagtgac cgcggcggtc agcccggtgc ggagcttctt aggcgccggc
    13081 agcggcaccg tctcccgcag gtcctcttcc aggtctgcgt ggcaggaggt gagcaccgcg
    13141 tcgggttcgt agaaccggcc gatgcccagc tggaagccgt gccgggcgtt gtcggtgcgg
    13201 tagttcagca gcagcgactc cccggccagg tcgtcgccgg cgccggccca ccggccccgg
    13261 agcaccgtgt ccggggtacg caccacagta gatgtcgagt agatggatac caggctgtgc
    13321 tgcatcgcga agctgcccac agcccgtagg tagtcgtggt cggcgagcgc cgcctcgacc
    13381 tcgtctttcg tgcgttggta aggcacggtc ctccaccggt caggtcggga aacgggcgaa
    13441 agcacgacac aagggaggcc cgcagcgatc ggagcctccc ttgtgcgccg ctgttaccag
    13501 gagcagcagc tagtgcagca gcagttgccg ccgccgcagg tggtggaagc gcccggcgcg
    13561 accgtaacgg taagaccgcc ggtcgccgtg ctgccaacgt ggccagagaa gctcagcata
    13621 gctcctccct ttcctggtta gggcccgatc acgtgctacc ggagccacct cggtggggga
    13681 cgcgcgaacg cgcctgaaag gacgttagca acgtcacagc gaatgggtca aggtggagag
    13741 tgccaaccaa atccgcacgt cactgtgggt attccaggat cgaccagcga ctacgtagtc
    13801 cgttcggtca atctggtacg tcggtcgttc ggccggccgg cggagccgac tccggcgtca
    13861 tgcttctccc gcgtcgtgcg cgagcaccgc cagctgaatc cggttcgcca ggtcgagctt
    13921 tgtcaatgcg ctcgacacgt gcgctttgac cgtgccgacc gacatgaaca gctgctccga
    13981 gatctcggcg ttcgacaaac cccgcgcgac cgtgaccgcc acctctcgct ccttctccga
    14041 cagctggccg agccgggccc gggcccgcac cccccgaccg tccggctcca cgctcccggc
    14101 cacgtgggcc atcagcgtcc gggtcacgtc cggcgagagc accggctccc cgaccgccgc
    14161 ccggcgcacc gccgccacga tctcgtccgg cgaagtgtgc ttgagcagga aacccgccgc
    14221 cccggcccgg atcgaggcga gcacgttggc gtcgctgtcg aaggtggtga gcacgatcac
    14281 cgcgggtggg gcgctcgact ccgaccgcag cgcccgggtg gcgtcgatgc cgtcacgcac
    14341 cggcatccgg atatccatca gcacgacatc cggcaccagc cgagccaccg cctcgaccac
    14401 ctcaccgccg tcgctcacct caccgaccac ggtcaggtcc ggcgccccgc ccagcatcag
    14461 cttcagaccg gtgcgcacca gtgcgtcgtc atcgaccagc aacaccctgg tccgcgggtt
    14521 cgtctcgtcc accgtgccac ggtaaccggg ccgagagctg gaagatccca cccatcgcac
    14581 cgtgctccag ggtgccgccg tcgagggcga cccgttcgct gagcccggcc agcccggcac
    14641 cggtgccggg gatctcggcc gtccggccag ccggcaccgg attacttacc gccaccgcca
    14701 cctcggcgcc gggtgaacca ccgacccgta ccgccaccgg cgccgccggc gcgtgcttgc
    14761 gggcgttggt caacccttcc tgcaccaccc ggtagatggt gcgctgctcc tgcggccgca
    14821 gcgagccggt gaccaacgac ggatccagtt gcagcgtcac cggctgaccc gccgcccggg
    14881 cctcggctac cagctccgcc acatccccca gcgagggcgg tggctccgcc cgctcggtgg
    14941 cggccggctc ggtgccgcgc agcacggtga gcacctcccc cagctcggtc agcgcctggt
    15001 gggcgttctc ccggatcacc cgtaccgcct cggcgacctc ggcgccgctc aacggctgcg
    15061 ccgccccggc ctgtgctcgt tcgctgcggt acgccaacgc gcccgcgtgc accgagagca
    15121 gcgagatccg gtgcgccagc acatcgtgca tctcccgggc gatccgttcc cgctcggact
    15181 ggcgggcccg ggcgagccgc agctgctgct cctgccgctc ctgccgagcc tcccgccgca
    15241 ggcccagcag cacctgccgg cggaaccgca ccaccagccc ccaggccagc ggcaacccga
    15301 acatccccac gacccagccc acgtagaccc cgagcgacaa cccgggtggc tggtaggtga
    15361 gtgcgaaccc cagcccctga acgagctgcg gcgcggtcac cgcgaccgcc ggcaaccagc
    15421 cgcggtggat ggcgacggtg aagatcatca ccaggacggc ccccatcgct gcgccggaga
    15481 ccgcgagcac cggcaccatc gcgatcgcga tcgccagcgg ataccgccgc cgccaccaca
    15541 ggctcaaaca cgccaggcca cccacccagg ggtccatcgc cagcatccag tcgggcacgg
    15601 ccgcgacgta cgccggatct gccgatccgg tcgtcaggct ccgcgactcg ttgagccaga
    15661 gcgccacggc gaacagaaag agcaccgtat cgaccagcca gtcgcggacg gtacgcccgc
    15721 tgctggtgcg gccgtcgacc gccgccagct cgccgggcag cgcccagact ggcacccccc
    15781 tgccctcgct ctgccgcatc ccccgagcgt acgggcgtca gctcaacgtc gacgttcgcc
    15841 ggtcggccag gaactctggc cgcccgacca gctccggtag tcacccggca gatgtccgca
    15901 ggtccgccga gaccggaaga ttccggcatg aagttgctgg cccgggagcc gatccgcctc
    15961 cgctcacccg cccatccggt gcatccgcgc gctcgctggt ggtggacgct gcgcgcagtc
    16021 gcactggtgg tgccgctgct cgccgctgcc gtggtagcca ccttcgtggt ccccggggcg
    16081 gcgtggctgc ggccgctgct gccggtggcc gggctactcg cgatggccta cctggtggtg
    16141 atgccgctgt ggcgctacca ggtccaccgg tgggaggtta ccgagcaggc cgtctacgcc
    16201 gccaccggct gggtggtgcg ggaatggcgg atcagtccga tctcccggat ccagaccgtg
    16261 gacacccgcc gcgggccgct ggagcaactg ctggggctgg ccgcggtggc ggtgaccacc
    16321 gcgtcggcgc acggcacggt ctacatcgtc ggactcgacc acgagaccgc ccagcgcacc
    16381 gccgaccggc tcacggagat caccgaggcg accccgggag acgcgacgtg accagtcggg
    16441 aacctgccgc acccgcgatt tcggaggtca ccgacccgcc accccggtcc ccttcaccgg
    16501 agccgccgtg gcggcggttg gactcccgca tgatcctggt ggacgcggta cagacgctgc
    16561 tcgccctgac cccggcggtg gcggctgtga ccatcttcgg ggtggagccg agcctcggca
    16621 cgctctggcc ggcgctggcg gtcgcggcgt ggggcgtcgt cagcgccggc accgacgcgc
    16681 tgcgctggat caagacccgg taccggatca ctgacgagta cgtcgaaggc cgcaccggcc
    16741 tgctggtgcg gcagtaccgg tcggtccgcc gcgaccggat ccgcagcgtg gacaccaccg
    16801 cgacgctccg gcaccgactg ggtggcctac gagtagtgtc gatcggcgct gggcagcagg
    16861 ccaacaccgg cgaggcagcg ctggcgctgg acgcgatctc tcgatccgac gccgagcggc
    16921 tacggcgaga cctactcggc gaggcggcgc cggcagcggc cgcgaccggc gatcagcagc
    16981 ggcccgagcc accgtccgac ccggtcctcg ccgagctgcg ctggtcctgg atcggctaca
    17041 acctgttcag cgtctgggcg tacctcgccg ccgccggggt gctgtggggc gcgatgtggc
    17101 tcggtggcag cgtcgggctg gacctggtcg gctgggttac cgggctgctc gactggcggt
    17161 cactcggctg gttctggtcg gtcatgatcg ggttcgcggc gatcagcctg ctcggcgtcg
    17221 gggtgctggc cacgggcttc gtcaccgaat actggcggtt ccggctcacc cgagtgcccc
    17281 gccccgaggg ctcggcgctg cggaccagcc aggggctgtt caagacccgg cagatcgatc
    17341 gggacgaggg gcggatccgc ggcatccaga tcagcgaacc ggtgctgtgg cgctggctcg
    17401 gcgtcgccga caccaacgtg atcagcaccg ggctgaacga ggggggtctc agcccggcca
    17461 gcaccatcct gccccggggg ccggtgacgg tcgcccgccg ggtggccgcc gaggtgctcc
    17521 gcgccgcgcc gaacccgttg acggcgccgt tacggccgca cccggccgcc gccggccgcc
    17581 gccgctactg gtgggggatc gcgatcgccg ccgcggtggt ggcggcggcc ggcatcgccg
    17641 ccaccaccat cgagccggtc ccgaactggg caccgctgct agcgtcggcg ctgctcccac
    17701 tgaccctgct cgcagccgcg gtcgcctacc gggcactcgg ccacaccctc gccgggtcgt
    17761 acctggtggt ccgttccggc ctggtcagcc gcgccacggt cgcgctgcac gggggtgcga
    17821 tcgtgggttg gcgcctccgg cagtcgctgt ggcagcggcg gctcggactc ctctcgctca
    17881 ccgccaccac cgccgccggc tacggcgcat acgaggcgac cgacctggcc gccgacgacg
    17941 cactcgccct cgccgaccag gcggcgcccg ggctcctccg gccgttcctg ctcaccgacc
    18001 acgagcccgg cggcgaccgg tccggagacc cgccgccggg cagcaaggag atcaacgatg
    18061 gttgaacctc gccgaaccgt cgtggccgac cccagctggg tcagcctgct gttctgggta
    18121 ggcttcccgg tcttgggtgg cgccctcggg gccgcgctgc gctggctggt cccctggttg
    18181 ctctccctgc cgtggacgcc gttgccgggc ccgctgcggt tggtcgagaa cacaccgagc
    18241 ccatggggca ccgtggtggc ggtggcgcta ggcgtgctcg ctggcctcgg attggcttat
    18301 tcggcagcca acgaccagct ccgggtggtg gtcaccgacc atcagatcgc ggtcacccgg
    18361 gccggtgcca ccaccgagtt tgcccggcac cgcgtccagg gggtgttccg cgacggcaag
    18421 caactggtcc tactcggcac cgaggcccag gagctggcgc gggaggcctc cgacctaccc
    18481 gagccggcgc tccgagcggc ctttgtgggc cacggctacc gttggcacgc cgatggtgac
    18541 ccgtacttcg acgattttcg ccggtgggta cccgggcttc ccgagttgcc gcccggcgcg
    18601 gacgccctct tcaccgcccg ggagaaggca ttgcacgacg aggactacag cgacgcccgg
    18661 caactacgcg acgaactcga cgcgctcggc gtcgtggtgc gggatgacca gaccagacag
    18721 ttctggcggc ggcaccgagc caacggtgcg ccgcacgact agccagtcgg tgcccggcgc
    18781 tagccagccg accgatgcga ccgaacggac gtcgtgggca ggcttgcccc gcgtcgaggg
    18841 caacccgacc aaccaaggta aggagcaggt tgtgacagaa ccggtgctgg agtgcaagca
    18901 cctgcgtaag gcgtacgggc agctgacagc ggtcgacgac atcagcttca gcatccgcga
    18961 aggtgagacc tacggcttgc tgggacccaa cggcgcggga aagaccacca ccatctcgat
    19021 ggtcgtgggc atcctcgccc gcgacggggg cgaggtcacg gtcgccgggc agccgcacgg
    19081 ggtcaaccgg accgccacca aggcgatgat cgggtatgtc ccgcaagacc tcgccctcta
    19141 cccggacctc accgcgctag agaacctgcg gttcttcggc aatctctacg ggctgcacgg
    19201 aggtgcgcaa aagcggcggg tcgccgaggt ggtcgagctg gtcgggctca gcgaccgggc
    19261 tagcgaccgg gtcgacaaat tctccggcgg gatggcacgc cggctccaca tcgccgtcgg
    19321 gctgctgaac cagccgcggc tactgatcct cgacgagccc accgccggcg tcgatccgca
    19381 gagccgcaac gcgatcctcg ccagcgtgca acagctcgcc gaggaggggc tggcggtcct
    19441 ctacaccacc cactacatgg aggaggccga acggctctgc gaccgggtag gtatcatcga
    19501 cgaaggtcaa ctcaaggctg aaggcacccg gcgggagctg gtccgcctgg tcggcagcca
    19561 ggacgagatc gtcctgacca ccgagggtga tccggccgcg gccgccgacg cgctcggcaa
    19621 gctgcccgag gtcggcaccc tcacccggga agagtcccgg atccggctga tggtcggcga
    19681 ggcggcgccg ctgctgccga cggtgctggc ggccgccacc ggcaccggca ccacggtccg
    19741 gtcagtggag gtccgccaac ccaacctcga agcggtcttc ctgcacctga ccggcaaggc
    19801 gctgagggac tgatcaaccc atgcggacga taatccacct caccgccaag gacctacggc
    19861 aacaactgcg caacggcacc ctgctgctgt tcgcagtggt cctgccgcta ggcctggcgt
    19921 tcatgttcaa cagcctgatg gcgccgggcg acccccagct caacgtctcc tatggagtcg
    19981 tcgacgagga cggtggtgaa ctcgccaccg tcttcaccaa cgaggtcctc accgcgatcg
    20041 cgaccgacag cagcttcgag atcgagccag tcaccgaccg ggagaccgct caccggctcc
    20101 tcgacgatca ggaccaggac gcggtcttca tcctgccggc cggcttcacc gaccaggtca
    20161 acgccggcca ggaggcgcgg atcgacgtga tcggtcatcc cgacgccggg atcgccgtcc
    20221 agatcgcgcg ggagatcgcc caggcattcg ccgccgagct gcgcggcgtc cagctggccg
    20281 tggcggtcgg cggcgccgac gacccggacg cggaccccgc acacctggcc gaacaggccg
    20341 ccgagctggc cgcaccggtg gtgcttgcgg tagacgactc ggtcgacgat cgggagctct
    20401 ccagcaacac ccactactcg gccggcatgg cggtcttctt tctgttcttc accgccatgc
    20461 tcagcgtaag tgggctcttg gaggagcgta gccagggcac catggcccgg ctgctggccg
    20521 ccccgagcgg ccgccccgcg atcctggccg gcaagctgct cagctcggtc gtggtcggtg
    20581 tggccgcgat gaccgtcctg atcggcgcct ccaccctgct cctcggcgcc agctggggtg
    20641 acctgcgcgg ggtggcggta ctggtggtcg cggtcgtcct cgccgcggtc gcgatcatgg
    20701 cgctgctctg ttccttcgcg aacaccgccg aacaggccag caactggatg tcggtactgg
    20761 cggtcctgtt cggtctattc ggcgggtcgt tcgtgccgct ggcccagttt ggcggattgg
    20821 cggtcatcag ctacgccacc ccacaccgct ggttcttgca aggcctgtcc gaactcaccg
    20881 gcgccggacc ggccgcggcc atagtgcccg cgctggtgct gacgggcatc gccgcagtgg
    20941 ccttcgcggt cacgctcctg cgtatcgaca aggtggtgag agcatgaaga tgctggcgat
    21001 cgccgggctg aacctacgcc ggctcttccg gtaccggccg aacgtcttct tcgtgatcat
    21061 tggaccgctc ctcttcctgc tggtgttggg gatgctcttc ggcggctccc aaccggtacg
    21121 catcggagta gtcgacggcg gcgggccact ggccgagcgg ctcaccgacg ctctcgccga
    21181 ggacgaccgg gtcgagctca cccgcttcga cgaccatgcc gagctgcaga cggagctgga
    21241 gcggggcctg ctcaacgccg gggtcgtcat ccccgacgac tacgaccagg tggtcggcga
    21301 cggcgagcag gcagcggtcc gctatctggc ccgcgccgac gatccgctcg ccgccgacct
    21361 cggagtctgg gtgcggtcgg tgatcccgca ggaggccgcg ctgctccggg ccgcccagtt
    21421 cggggcgcag gagcatggcg cgccggtcga ccaacacctg cgtgcggccg agtccgcggc
    21481 ggcgaccatg cccggcatcg aggtcgcggt gaccaccacc ggggaggcgc agatcccgga
    21541 agggctcagc cagttcgcgc cgatggcgcc ctcgctgctg ctgctgttcg tcttcttcac
    21601 ctcgctgatg gcggcgctcg ggctggtgga ggcgcgccgg ctgggcgtca tcacccggat
    21661 gaccgccacc cctaccccga tccgaaccct ggtcgctggc gaagcgctcg gccggttcgc
    21721 ggtcgcgctc acccaagggc tcatcgtcct gctcggatcg gcgttgctgt tcggagtgga
    21781 ctggggcgac ccgatcggcg ccgccgccgt acttgtgctg ttctgtctgg tcggcagcgg
    21841 cgcggcgatg ctgctcggcg cgctgttccg caacgaggga gccgcgatgg gcgtcgggat
    21901 ggggctcggg ctggggctgg ccgcgctcgg cggcaccatg ctgccgctgg agctgctctc
    21961 cgatcaggtg cagacgatcg cgaaggcgac cccccacgcc tgggggtacg aggcctacag
    22021 cgaactggtc cggcacggcg gcaccgtcac cgacatcctg ccgcagctgg gggcgctggc
    22081 cggcttcgcc gcggtgctct tcaccctcgg ggcctggcag ctgcagcgca gcctcacccg
    22141 atgaccaccg tcgacaccgc cggtccgccg gcgcaccggg gagctccggg tttgccctga
    22201 gccggcatcg gggtcgtccc gcagcgggaa atccgccccc actccgcctc gggtgggagg
    22261 gaaaccacaa cgggatggct gacgatgggt ggtgccggcc gatgaacgcg ccggccggca
    22321 ccaccaccga atcaggagta aaaatgaacg cagcccagcg aaccgcgcac aaccgggccg
    22381 gcggcggggc gttcgccgcc cgggcggagg acgtatggaa ggtctacggg tcaggtgaag
    22441 cccaggtcgt cgccctccgc ggcgtcaacc tcaacctcac caaaggccag ttcaccgcca
    22501 tcatgggccc ctccggctcc ggcaaatcca ccctcatgca ctgcctcgcc ggcctcgaca
    22561 ccgtcacccg cggcaccgtc tacatcgacc aaaccccact caacggcctc cgcgacaaca
    22621 ccctcaccaa actccgccgc gaccaaatcg gcttcatctt ccaacaattc aacctcctcc
    22681 ccaccctcac cgccaaagaa aacatcctcc tccccctcaa catcgccggc cgcaaacccg
    22741 acccccactg gtacgacacc atcatcaaca ccgtcggcct caccaaccgc ctccaccacc
    22801 gacccaccca actatccggc ggccaacaac aacgcgtcgc ctgcgcccgc gccctcatca
    22861 ccaaacccca cgtcatcttc gccgacgaac ccaccggcaa cctcgacagc cacagcggcg
    22921 ccgaaatcct caccttcctc caacaaagcg tccaccaaca ccaacaaacc atcgtcatgg
    22981 tcacccacga ccccgtcgcc gccgcctacg ccgaccgcgt catcttcctc gccgacggca
    23041 acatcgtcga cgaactcgcc aaccccaccg ccgaagccgt cctggacacg atgaagcggc
    23101 tggacacgct ggtcgccacg gatgccgccg aggcggtggc ctgatgctcc gcaccaccct
    23161 gcgcagcatg ctgcaccgca agctgcggct attgctctcc ggattagcgg tgatcctcgg
    23221 tgtgatgttc gtcgccggca gtctcattct gaccgacacc ctcggtcgct cattcgacac
    23281 catcttcgcc gacgcctacg ccgagaccga cgtgctggtc caaggtgaag cagccatcca
    23341 ggtctcggag ttggagggtg agcaggtacc agccaacatc cccgccgaca ccgccgacac
    23401 ggtggc
//
