LOCUS       NZ_CP070499            10375 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Natronosporangium hydrolyticum strain DSM 106523 chromosome,
            complete genome.
ACCESSION   NZ_CP070499
VERSION     NZ_CP070499.1
KEYWORDS    RefSeq.
SOURCE      Natronosporangium hydrolyticum
  ORGANISM  Natronosporangium hydrolyticum
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Natronosporangium.
REFERENCE   1  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Natrosporangium hydrolyticum gen. nov., sp. nov, a haloalkaliphilic
            actinobacterium from a soda solonchak soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) Bioinformatics, Leibniz Institute DSMZ,
            Inhoffenstr. 7B, Braunschweig 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-MAY-2020
            Assembly Method                   :: HGAP v. 4
            Assembly Name                     :: 999_Micromonospora_sp_DSM106523
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 580.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016925615.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 06:45:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,188
            CDSs (total)                      :: 5,131
            Genes (coding)                    :: 5,046
            CDSs (with protein)               :: 5,046
            Genes (RNA)                       :: 57
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 85
            CDSs (without protein)            :: 85
            Pseudo Genes (ambiguous residues) :: 0 of 85
            Pseudo Genes (frameshifted)       :: 18 of 85
            Pseudo Genes (incomplete)         :: 72 of 85
            Pseudo Genes (internal stop)      :: 4 of 85
            Pseudo Genes (multiple problems)  :: 8 of 85
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:11:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2544208
            Orig. end                         :: 2554583
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070499.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10375
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="11"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10375
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10375
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5375](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5375
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    192..205
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            503..1348
                     /locus_tag="JQS43_RS11220"
                     /old_locus_tag="JQS43_11160"
     CDS             503..1348
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013722.4"
                     /locus_tag="JQS43_RS11220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11160"
                     /product="MaoC/PaaZ C-terminal domain-containing protein"
                     /protein_id="WP_239679020.1"
                     /transl_table=11
                     /translation="MSAQPTLADRSASFPCDVGDVADYRRAVRAPLGITVAADGHASPL
                     HPFVLAHPRFEQVVEGFSTQSAPARPIHLSQELTMSRLVRGGEQVTVTIEVPGARREPR
                     GVRVALRGLLTGADGAPVAELATAVLLAGAVTPEPFGTIPARPAPRPPGPVIGQTTLRH
                     AITMDSVRRYAAASGDRNPIHLDPQAARQAGFPGVIVHGMSLLALVCEEVIDRYGDGDP
                     ARIQGIGCRFSSPVSPAATIQTTLADHGGVVRFSSATDQGAALKSGWVALTTAGRERSG
                     "
     misc_feature    839..841
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1345..2886
                     /locus_tag="JQS43_RS11225"
                     /old_locus_tag="JQS43_11165"
     CDS             1345..2886
                     /NRPS_PKS="Domain: AMP-binding (28-409). E-value: 2.2e-61.
                     Score: 199.6. Matches aSDomain:
                     nrpspksdomains_JQS43_RS11225_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="JQS43_RS11225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11165"
                     /product="AMP-binding protein"
                     /protein_id="WP_239679021.1"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-62, bitscore:
                     209.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPQSADLRPRNGAEPGRPAPTEIGLLVAAQAEHRPTAVAIQYGD
                     TAVTYRDLAALATQAQQRLAAAALAPAEPICLSATKTPQTIATILACLLTGRPVLLAAA
                     ALPDDVAEQLAAVAGCRTSWDDRTFRRVAAAPDTPPSPPPAGTSFMLTTSGSTGLPKVV
                     PLPSTAVARFVEWAAATFGIDAGSTVLNYAPINFDLCLLDVWTTLAQGGRVVLVDPDRA
                     ANGRYLADLLRRHRPQVVQAVPIYFHLLAEAESGAAASGEPGFDSVQQVMVTGDAPTEQ
                     VLAELPCLFPDARRWNVYGCTETNDSFCHEIRDDTTVPVPIGDPLPGVAAEIVTGDGAV
                     LAGPGIGELWVCTPFQSSGYLTAGHAGRFAARPGGADGRQWFRTGDLVQRGPAGELTLV
                     GRTDHQVKIRGVAVNTAQVEQVLLAHPKVREAAVVAVPDPVTGHRLLAGVRPHPDARLN
                     SLTLRKHCASRVSPAAVPSTLRIIGDPLPRTTTGKVDRRAVSALLHPPITKGHPA"
     aSDomain        1429..2571
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQS43_RS11225_AMP-binding.1"
                     /evalue="2.20E-61"
                     /label="JQS43_RS11225_AMP-binding.1"
                     /locus_tag="JQS43_RS11225"
                     /protein_end="409"
                     /protein_start="28"
                     /score="199.6"
                     /specificity="substrate consensus: Ala"
                     /tool="antismash"
                     /translation="AAQAEHRPTAVAIQYGDTAVTYRDLAALATQAQQRLAAAALAPAE
                     PICLSATKTPQTIATILACLLTGRPVLLAAAALPDDVAEQLAAVAGCRTSWDDRTFRRV
                     AAAPDTPPSPPPAGTSFMLTTSGSTGLPKVVPLPSTAVARFVEWAAATFGIDAGSTVLN
                     YAPINFDLCLLDVWTTLAQGGRVVLVDPDRAANGRYLADLLRRHRPQVVQAVPIYFHLL
                     AEAESGAAASGEPGFDSVQQVMVTGDAPTEQVLAELPCLFPDARRWNVYGCTETNDSFC
                     HEIRDDTTVPVPIGDPLPGVAAEIVTGDGAVLAGPGIGELWVCTPFQSSGYLTAGHAGR
                     FAARPGGADGRQWFRTGDLVQRGPAGELTLVGRTDHQVKIR"
     CDS_motif       1789..1839
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQS43_RS11225_0001"
                     /evalue="7.90E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="JQS43_RS11225"
                     /protein_end="165"
                     /protein_start="148"
                     /score="12.5"
                     /tool="antismash"
                     /translation="FMLTTSGSTGLPKVVPL"
     misc_feature    1819..1821
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       2539..2601
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQS43_RS11225_0002"
                     /evalue="1.50E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="JQS43_RS11225"
                     /protein_end="419"
                     /protein_start="398"
                     /score="20.7"
                     /tool="antismash"
                     /translation="VGRTDHQVKIRGVAVNTAQVE"
     gene            2883..3143
                     /locus_tag="JQS43_RS11230"
                     /old_locus_tag="JQS43_11170"
     CDS             2883..3143
                     /NRPS_PKS="Domain: PP-binding (18-76). E-value: 9.8e-11.
                     Score: 33.8. Matches aSDomain:
                     nrpspksdomains_JQS43_RS11230_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1147: putative acyl carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.4"
                     /locus_tag="JQS43_RS11230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11170"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_239679022.1"
                     /sec_met_domain="PP-binding (E-value: 4.1e-09, bitscore:
                     35.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 0.011, bitscore:
                     14.3, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEIDVIKAFIIDEFLPDVSPDEFGPDDDLLADGVIDSLGLLKLI
                     AWLEDRFAVAIDDAALDPNNFRSVSAMASFIVQSRLQTSRS"
     aSDomain        2937..3110
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQS43_RS11230_PP-binding.1"
                     /evalue="9.80E-11"
                     /label="JQS43_RS11230_PP-binding.1"
                     /locus_tag="JQS43_RS11230"
                     /protein_end="76"
                     /protein_start="18"
                     /score="33.8"
                     /tool="antismash"
                     /translation="VSPDEFGPDDDLLADGVIDSLGLLKLIAWLEDRFAVAIDDAALDP
                     NNFRSVSAMASFI"
     gene            3145..4185
                     /locus_tag="JQS43_RS11235"
                     /old_locus_tag="JQS43_11175"
     CDS             3145..4185
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012800.4"
                     /locus_tag="JQS43_RS11235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11175"
                     /product="hypothetical protein"
                     /protein_id="WP_239679023.1"
                     /transl_table=11
                     /translation="MHETLHRLLQDRTPVDLDGWRRLWDDLEAGALDRAEAMALLASLT
                     SRLPNIETLRNLVVSLRERSSPMTQLLPGAVNVVGTGGGPRTFNISTAAAFVAAAAGVP
                     VVKTGSRAYTSQYGSVDLLDRLGIRLTSSSEQTAESLDRFGIAFAGAVVYPRVLTQLAR
                     LLVPVGMAPFGRFLNGVGPLLAAVPVTAQLTGVSAAGSLDQLRVLADDLPHEVWLVSND
                     AGADELLGFADNLICTNRGDVHRIRPGQFTAGDGGLSDLRPVARRHELIPHFLAVLAGD
                     CGPAEAEAVCLNAAALAMAGGQAASWGQAVEAAYRVIRDGTARTLAEQLRESAGARPGT
                     LEARGG"
     gene            4178..4990
                     /gene="trpA"
                     /locus_tag="JQS43_RS11240"
                     /old_locus_tag="JQS43_11180"
     CDS             4178..4990
                     /EC_number="4.2.1.20"
                     /GO_function="GO:0004834 - tryptophan synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="trpA"
                     /inference="COORDINATES: protein motif:HMM:NF012511.4"
                     /locus_tag="JQS43_RS11240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11180"
                     /product="tryptophan synthase subunit alpha"
                     /protein_id="WP_239679024.1"
                     /transl_table=11
                     /translation="MADFFPGRADGQPGLALFLNAGDPPLEVLVDVLVALDALGVDCVE
                     LAVPFPDSVTDGPVIRRSAARALAGGVGLPETLAFVARTRQLLRRTRIALLADWRFSLK
                     DGAPDELARRVADSGVDGLLVHGLPPRLRPAWQAAVEAVGLPVVGTCYQGVSTPQTMAM
                     AARQATAYLYLVAHYGRSGTRASNGFASLAATITSLRGLTNAPIAVGFGVTSRADVAAV
                     AAAGADAAIVGSATVATVERSLANRSDVAAEISEFVCSLQQPAPATNS"
     gene            5001..5375
                     /locus_tag="JQS43_RS11245"
                     /old_locus_tag="JQS43_11185"
     CDS             5001..5375
                     /GO_function="GO:0033990 - ectoine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF018088.4"
                     /locus_tag="JQS43_RS11245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11185"
                     /product="ectoine synthase"
                     /protein_id="WP_239679025.1"
                     /sec_met_domain="ectoine_synt (E-value: 6.2e-31, bitscore:
                     105.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIRNIADVKTVEWGNGLSRRFLLRSDGMGYSVTDTIVRSGSKSR
                     LEYRNHLEACYCIGGRGEVIAMDGTSHPITPGTLYALDQHDPHYLVADPYQDLRLVCVF
                     SPALRGDEVHRLDEPDFSHY"
     gene            5408..6544
                     /locus_tag="JQS43_RS11250"
                     /old_locus_tag="JQS43_11190"
     CDS             5408..6544
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.4"
                     /locus_tag="JQS43_RS11250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11190"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_239679026.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 7e-19, bitscore:
                     66.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 9.7e-22, bitscore:
                     75.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 7.5e-32, bitscore:
                     108.9, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEWNADQVALRDGVVAAASALRADGPVDDEASRFQENWQLLSKL
                     GLLGLPFEETYGGLGQDLVTTMYVLEGLGEACRDGGLSFAATTAICSVGVPLNRFGTAA
                     QKQRYLPRICAGAVIGAHAITESVGGSDALKMRTRARRDGDHFVLDGAKTFVSNGPVAD
                     LLMIYAATRPGGGALGVTAFLVERDTPGLTVGQPIAKMGLATSPLSDVYLDQVRVPASQ
                     VVGRVGGGFLVLDYVMKREVLFSFIVNVGEMRHRVERCIGYARSREQFGQPIGSYQSVA
                     NRIVDMKIQTETARKWLYDAALTVAADRVATSDIAIAKLIASEANLETAVSAVRIFGGN
                     GYMTEFGLERDVRNAVAGPIYSGTNEIQYNRIAAMLGL"
     gene            6622..7290
                     /locus_tag="JQS43_RS11255"
                     /old_locus_tag="JQS43_11195"
     CDS             6622..7290
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012900.4"
                     /locus_tag="JQS43_RS11255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11195"
                     /product="hypothetical protein"
                     /protein_id="WP_239679027.1"
                     /transl_table=11
                     /translation="MTHHHEGELLADAGVDLVGLWWAVPGGHAELSSDRVAELATTVRG
                     TGQLAPVLVTFSADIERIVSTMRETGISWLQLHAYQPPAVVRELRRRLGSPATIVKVLH
                     VGAGGCVEQRFVPAYTRAGADLFLVDGATPDGRLGSTGVPLDPAVVLPLVDSLDQGFLL
                     AGGLTAANAGEYAGIAGHPRMCGIDVDTGARGSDGRFDSGQVGGLARQWRVGRREERDD
                     "
     gene            7283..7996
                     /locus_tag="JQS43_RS11260"
                     /old_locus_tag="JQS43_11200"
     CDS             7283..7996
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012444.4"
                     /locus_tag="JQS43_RS11260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11200"
                     /product="hypothetical protein"
                     /protein_id="WP_239679028.1"
                     /transl_table=11
                     /translation="MTSAFVTAIQRAPRPLVMEVKRRDGHGRDLLAGRSVAAHVRGFDG
                     AAACLSVVTGRWFGGDLELLQEVRRLTDRPLLQKDFITRRDQLRTARDLGASAVLLTAG
                     LLPRSSLGNLVDACLSLGLTPFVEVTTADEVAAIPDPGGCVVAVNNKDIRNRERGPGDP
                     GRSLALLPQLRRAGVDCRVSASGIDQPAVAVGLLQAGFSALLIGTSLLRAERLSDWLAE
                     FDRGWSADQAVLSSG"
     gene            complement(7972..8961)
                     /locus_tag="JQS43_RS11265"
                     /old_locus_tag="JQS43_11205"
     CDS             complement(7972..8961)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018728818.1"
                     /locus_tag="JQS43_RS11265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11205"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_239679029.1"
                     /transl_table=11
                     /translation="MDAFGELLGQLRARGAFVLRSILTPPWSLRVVDRAPLCLVTMVHG
                     HAWILPDGGEPARLSRGDVALFRGPDCYTLADEPDREVQIVIHPGQRCTTPQGRDMAEA
                     MRLGVRTWGDAQEGAAVMLSGTYQLDGDVSQRLLRILPPVLTGRTKPSDAPRIALLSQE
                     IARDEPGQELILDRLLDLLLVSALRQWLSSSDAPDTGWYRAQHDPIVGPAIRLLHANPA
                     YPWTVANLAARVGVSRAALARRFTSLVGEGPMTYLSSWRLDLAADMLRESDATVASVAR
                     QVGYSSAYALSAAFKRVRGVSPSEHREVGQAVPAEPRVNGAQPLLSTA"
     misc_feature    9031..9049
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 22.92"
                     /tool="antismash"
     gene            9098..9568
                     /locus_tag="JQS43_RS11270"
                     /old_locus_tag="JQS43_11210"
     CDS             9098..9568
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020177.4"
                     /locus_tag="JQS43_RS11270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11210"
                     /product="anthrone oxygenase family protein"
                     /protein_id="WP_239679030.1"
                     /transl_table=11
                     /translation="MSGLALIVAVVTTGLVAGIFLGFSISVMPALARTGDRTFVEVMQR
                     INAAIQNPLFGLVFLGAVVSIGVAGWLHASREEMFSWILAGAVGYGLTLLITFAINIPL
                     NNRLDRAGPAGGLANPRSPRRAFERLWVGAHHVRTLTCVAAFGCLTLALAEL"
     misc_feature    9107..9109
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9347..9349
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9565..10308
                     /locus_tag="JQS43_RS11275"
                     /old_locus_tag="JQS43_11215"
     CDS             9565..10308
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (131-194). E-value: 5.6e-18. Score:
                     57.1. Matches aSDomain:
                     nrpspksdomains_JQS43_RS11275_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1060: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018786489.1"
                     /locus_tag="JQS43_RS11275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_11215"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_239679031.1"
                     /transl_table=11
                     /translation="MTAYSPVGGARPAEADRLSPPPTPSGGSLLAQILPPQAHGVEAYH
                     DAPAGSLYPEEAALLARSGAGDKRRREFTTVRACARAALHELGVPPAPVLPGPGRAPNW
                     PAGVTGSMTHCDGYRAAAVAATADLRSLGIDAEPAGPLPAGVLGLIGSRAERAQVAHLA
                     RERPEVPWDRLLFCAKEAAYKAWYPVTGQWVALADIAVEVGPEDGRLRARPPGGGALRE
                     LPGRWAVAGQRDRAGLLLVAVTVRV"
     aSDomain        9958..10146
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQS43_RS11275_ACPS.1"
                     /evalue="5.60E-18"
                     /label="JQS43_RS11275_ACPS.1"
                     /locus_tag="JQS43_RS11275"
                     /protein_end="194"
                     /protein_start="131"
                     /score="57.1"
                     /tool="antismash"
                     /translation="LGIDAEPAGPLPAGVLGLIGSRAERAQVAHLARERPEVPWDRLLF
                     CAKEAAYKAWYPVTGQWV"
ORIGIN
        1 gcgctcgtga tgcgcgggct cggggggtgc gggggcgcgc ggtgctggcg ggctacgccg
       61 ctaccaccga tgcccaccac ctgagtatgc cggcgcccga cggcatcggg gcgatcgccg
      121 cgattcgggg cgcgctcgct gacgccagct tgacccccgg cgacatcgcc cacgtcaacg
      181 cccatgggac gtcgacgccg ctcaacgacc ggatcgaagc cgccgcgctc cgcgaggtct
      241 tcggtgatcg cgtgccgccg gtgaccgccg ctaagggggt caccggccac ctgatcggag
      301 ccgctggggc ggttgagctg atcgcgaccg tacttgcggt ggagtacggg ctggtgccgc
      361 ccaccgccaa ccatcaggaa acggagcctg ggatggagat cgacgtggta cacggcagac
      421 cccgccagct cgcgcccggt ccggcgctgt ccgaatcgtt cggcttcggt ggccacaacg
      481 cctgcctcgt ggtggtgccg agatgagcgc ccaacccacg ctggcggacc ggtcggcgtc
      541 tttcccgtgc gacgtcggcg acgtggccga ctatcggcgg gcggtccggg caccgttggg
      601 gattacggtc gcggccgacg gtcacgcctc cccgctgcac ccgttcgtgc tcgcgcaccc
      661 ccgcttcgaa caggtggttg aagggttcag cactcagagc gcaccggctc gcccgatcca
      721 cctcagccag gagctgacca tgtcccggct ggtccgggga ggcgaacagg tcacggtcac
      781 gatcgaggtg ccgggtgctc gccgggagcc ccgcggagtc cgggtcgcgc tgcgggggtt
      841 actgaccggg gcggacgggg cgccggtggc ggagctggcc acggcggtcc tgttggcagg
      901 ggcggtgacg ccggaaccat tcgggaccat cccggcgcgg ccggcgccgc ggccaccggg
      961 cccggtgatc ggccagacca cgcttcgcca cgccatcacg atggacagcg tgcgccgcta
     1021 cgcggccgcc tccggcgatc gaaatccgat ccacctggac ccgcaagcag cgcggcaagc
     1081 cggcttccca ggcgtcatcg tgcacggcat gagcctgctc gcactggtgt gtgaggaggt
     1141 catcgaccgg tacggagacg gtgaccccgc ccggatccag ggtatcggct gccgcttctc
     1201 ctccccggtg tcgccggcgg ccaccatcca aacaacgctc gcggaccacg gcggcgtcgt
     1261 ccggttcagc tcggcgaccg accagggcgc ggcgctgaag agcggctggg tcgccctgac
     1321 caccgcggga agggagcggt cgggatgacc ccacaatcgg ctgacctccg gccaaggaac
     1381 ggcgccgagc cggggcgacc cgcacccacc gagatcggtc tactcgtcgc cgcccaggcc
     1441 gaacaccgcc cgaccgcggt ggccatccag tacggggata ccgctgtcac ctaccgcgac
     1501 cttgccgcgc tggccaccca ggcccaacag cggttggcgg ccgccgcgct cgcgcccgcc
     1561 gagccgatct gtctgtcggc gaccaagacg ccgcagacca tcgcgaccat cctcgcctgt
     1621 ctgctcaccg gccgaccggt tctcctggcc gccgccgccc tacccgacga cgtggccgag
     1681 cagctggcgg ccgtcgcggg ctgccggacc agctgggacg accggacttt ccgccgggtg
     1741 gccgccgccc cggacacccc gccgtcgccg ccgccggccg gcacctcctt catgctgacg
     1801 acctccggct ccaccgggtt accgaaggtc gtgccactgc cgtcgacggc ggtggcgcgg
     1861 ttcgtcgaat gggccgccgc aacattcggc atcgacgccg ggagcaccgt gctgaactat
     1921 gccccgatca acttcgacct ttgtctgctg gacgtctgga ccaccctggc ccagggtggt
     1981 cgggtagtgc tggtcgaccc ggaccgggcg gccaacggtc ggtacctggc agacctgctg
     2041 cgacggcacc ggccacaggt ggtgcaggca gtcccgatct actttcatct gctcgccgag
     2101 gcggagtctg gtgcggctgc gtcgggcgag cccggtttcg actccgtcca gcaggtaatg
     2161 gtgaccggag acgcgcctac cgagcaggtt ctcgccgagt tgccgtgcct gtttccggac
     2221 gctcgacggt ggaacgtcta cggttgcacg gagaccaacg acagcttctg ccacgagatc
     2281 cgcgacgaca ccacggttcc ggtcccgatc ggcgatccgt tgccgggcgt ggcggcggag
     2341 atcgtcaccg gcgatggggc ggtgctggcc ggcccgggca tcggtgagct atgggtgtgc
     2401 acgccgttcc agagcagcgg atacctcacg gcgggccatg ctggccggtt cgccgcccga
     2461 cccggcggtg ccgacggccg gcaatggttc cgcaccggtg acctggtcca gcgcggccca
     2521 gccggtgagt tgactctggt agggcgaacc gaccatcagg tcaaaatccg tggcgtcgca
     2581 gtgaacaccg cacaagtgga gcaggtgctg ctggcgcacc cgaaggttcg ggaagcagcg
     2641 gtggtcgcgg tgccggaccc ggtcaccggt caccgcctgc tcgccggcgt ccggccccac
     2701 ccggatgccc ggctgaacag cctcaccctt cgcaaacact gtgccagccg agtctccccg
     2761 gcagcggtac ccagcacgct gcggatcatc ggcgatccgt tgccccgaac cactaccgga
     2821 aaggtcgacc gacgcgccgt cagtgccctg ttgcatcccc ccattacgaa aggtcatcca
     2881 gcatgaacga gatcgatgtc atcaaggcct tcatcatcga cgagttcctt cccgatgtca
     2941 gtccggacga gttcggaccg gatgatgatc tgctcgccga cggagtgatc gacagcctcg
     3001 gcctgctgaa gctgatcgcc tggttggaag accggttcgc agtagcgatc gacgacgcgg
     3061 cattggaccc gaacaacttc cgaagtgtgt cggcgatggc ctcgttcatt gtccagagcc
     3121 ggctgcagac atcgaggagc tgaggtgcac gagaccctcc accggttgct ccaggaccgg
     3181 acgccggtcg acctcgacgg ctggcgccgg ctctgggacg acctggaggc gggcgccctg
     3241 gaccgggctg aggcgatggc gttgctcgcc tcgctcacga gcaggctgcc gaacatcgag
     3301 acacttcgta acctggtcgt ctcgttgcgg gagcggagct cgccgatgac gcagttgctg
     3361 cctggcgcgg tcaatgtcgt cggcacgggc ggagggccac gcaccttcaa catctccacc
     3421 gctgccgcct tcgtcgccgc ggctgccgga gtgccggtgg tcaagaccgg ctcgcgcgca
     3481 tacaccagcc agtacggatc ggtagatctg ttggaccggc tggggattcg gctgacgagt
     3541 tcatcggagc agacggccga atcgctggac cggttcggaa tcgcgttcgc cggtgcggtg
     3601 gtgtacccgc gggtgctgac ccagttggcc cggttgctgg taccggtcgg catggctccg
     3661 ttcgggaggt tcctcaatgg tgtcggtccg ctgctggcgg cggtgccagt taccgcgcag
     3721 ctgaccgggg tctcggccgc cgggtcgctg gaccaactcc gggtcctggc cgacgacctt
     3781 ccgcatgagg tttggctggt ttcgaacgat gccggcgcgg acgaactgct gggcttcgcc
     3841 gacaacctga tctgcaccaa tcgtggcgac gtgcaccgga tccgtccggg ccagttcacg
     3901 gccggcgacg gtgggctatc agacctgcgg ccggtggcgc ggcggcacga gttgatcccg
     3961 cattttctcg ccgtactggc gggtgactgc gggccggccg aggccgaggc ggtgtgtctg
     4021 aacgcggccg cccttgccat ggccggcggg caggccgcca gctggggtca ggcggtcgag
     4081 gccgcctacc gggtgatccg cgacggtacg gcccgcacgt tggcagagca gctgcgcgag
     4141 tcggcgggcg cgagaccggg cacactggag gcgcgcggtg gctgacttct tccccggccg
     4201 ggcggatggg caaccggggt tggcgttgtt cctgaacgcc ggcgacccgc cgctggaggt
     4261 gctggtcgac gtattggtgg cgctggacgc gctcggtgtc gactgcgtgg agctggctgt
     4321 cccgttcccg gactcggtca cggacggacc ggtgattcgg cggtcggcgg cccgggccct
     4381 cgcgggtggg gtcgggctgc ccgagacgct ggcgttcgtg gcccggacgc gccaattgct
     4441 gcggcgaacc cggatcgccc tgctcgcgga ttggcggttc agcctcaagg acggcgcgcc
     4501 ggacgagcta gcccggcggg tggccgacag cggggtcgat ggcttgctgg tgcacgggct
     4561 gccgccgcgg ttgcggccgg cctggcaggc ggcggtcgaa gcggtcggcc taccggtcgt
     4621 gggtacctgt taccagggtg tgtcgacgcc gcagacgatg gcgatggctg cccggcaggc
     4681 taccgcctac ctctatctgg tcgcacatta tggccgcagc ggcacccggg cgagtaacgg
     4741 gttcgccagt ctggccgcaa ccattacgtc gttgcgtggc ctcaccaatg cgccgatcgc
     4801 ggtggggttc ggggtcacca gccgggcgga cgtcgcggca gtagccgccg ccggggccga
     4861 cgccgcgatc gtcgggtcgg ccacggtcgc cacggtcgag cggtcgctcg cgaaccgaag
     4921 cgatgtggcg gccgagatat ctgagttcgt ttgttctctg cagcagccag caccggccac
     4981 gaacagctaa gggagttgac atgatcattc gcaacatcgc ggacgtgaag accgtggagt
     5041 ggggtaacgg gctgagccgg aggttcctgc tgcgctcgga cggcatgggt tactcggtca
     5101 ccgacacgat cgtccgttcc gggagcaagt cccggcttga gtaccggaac catctcgagg
     5161 cctgctactg catcggtggt aggggcgaag tgatcgctat ggacggcacc tcccatccga
     5221 tcacgccggg cacgctctac gcgctggacc agcacgaccc gcactacctc gtcgcggacc
     5281 cgtaccagga cctccggttg gtctgcgtct tctcgccggc gctgcggggc gacgaggtac
     5341 accggctcga cgagccggac ttctcccact actgagttgg gccgggccgg gatcggagag
     5401 gaacgcgatg attgagtgga acgccgacca ggtcgcactc cgggatggag tcgtcgccgc
     5461 cgccagcgcg ctgcgcgccg acggccccgt cgacgacgag gcgtcgcgat ttcaggagaa
     5521 ttggcagctg ctgagcaaac tgggtctgct cgggctgccg ttcgaggaga cctacggcgg
     5581 cctcggtcag gacctcgtca ccacgatgta cgtcctagag ggactcggcg aggcgtgccg
     5641 ggacggcggc ctcagctttg cggcgacgac ggcgatatgc agtgtcggcg tcccgctcaa
     5701 ccggttcggc accgcggcgc agaaacaacg gtacctgccg aggatctgcg ccggagcggt
     5761 gatcggtgcg catgcgatca ccgagtccgt cgggggatcg gacgcgctca agatgcgtac
     5821 ccgggcccgc cgagacgggg accacttcgt gctcgatggg gccaagacct tcgtcagcaa
     5881 cgggccagta gcggatctgc tcatgatcta cgcggcgacc cgcccgggcg gtggtgcgct
     5941 cggcgtcacc gcgttcctcg tggagcggga cacgcccggg ctgacggtgg ggcagccgat
     6001 cgccaagatg gggctggcga cctcgccgtt gagcgatgtc tacctggacc aggttcgggt
     6061 ccccgcgagt caggtcgtcg gccgggtagg tggtgggttt ctggtcctgg actatgtcat
     6121 gaagcgggag gtgctcttct cgttcatcgt caacgtcggc gagatgcggc accgggtcga
     6181 gcgttgcata gggtacgcac gttcgcgtga gcagttcggc caaccgatcg gctcgtacca
     6241 gtcggtcgcc aaccggatcg tcgacatgaa gatccagacc gagacggctc gaaagtggct
     6301 gtacgacgcg gcgctgacgg tagccgccga ccgggtcgcg accagcgaca tcgccatcgc
     6361 caagctgata gctagtgagg cgaacctgga gaccgcggtg tccgcggtcc ggatcttcgg
     6421 tggcaacggt tacatgaccg agttcgggtt ggagcgtgac gttcggaacg ccgtggcggg
     6481 gccgatctac tcgggcacga acgagatcca gtacaaccgg atcgccgcga tgctgggtct
     6541 gtgatggcgg ctaccgcggg catccggccg taccggcagc gagctggtgc gcccggtcgc
     6601 ggcctgttga aggtgtgcgg catgacccac caccacgagg gtgagctgct agccgacgcg
     6661 ggcgtcgacc tagtgggcct gtggtgggcg gtacctggtg gccacgccga gctgtcgagt
     6721 gaccgggtcg cggagttggc caccaccgtg cgggggaccg gtcagttggc gccggtgctg
     6781 gtcaccttca gcgcggacat cgagcggatc gtctcgacca tgcgggagac cgggatcagt
     6841 tggctacagc tgcacgcgta ccaaccaccc gccgtggttc gggagctgcg tcggcggctg
     6901 ggatcgccgg ccacgatcgt caaggtgcta cacgtcggtg ccggtggctg cgtggagcag
     6961 cggttcgtgc ccgcatatac ccgagcgggc gccgacctgt ttcttgtcga cggcgcgacc
     7021 ccggatggcc ggctcggcag caccggggtg ccgctggacc ccgcggtggt gctccccctc
     7081 gtcgactcgc tcgaccaagg tttcctgctg gcgggcggcc tgaccgcggc gaacgccggc
     7141 gagtatgccg ggattgccgg ccacccgcgg atgtgcggga tcgacgtcga caccggggcg
     7201 cgggggagcg atggccggtt cgattccggg caggttggcg gcctagcccg gcagtggcgg
     7261 gttggccgcc gggaggagag agatgactag cgcttttgtc acggccatcc agcgggcgcc
     7321 acggccgctg gtgatggagg tcaaacgtcg ggatgggcac ggtcgcgacc tgctcgccgg
     7381 ccgcagcgtg gccgcccacg tgcgggggtt cgacggtgcg gcggcctgcc tctcggtcgt
     7441 taccggacgc tggttcggcg gggaccttga gctactccag gaggtgcgcc ggttgactga
     7501 ccggccgttg ctccagaagg acttcatcac ccgtcgagat caactgcgta cggctcggga
     7561 cctcggcgcc tcggcggtgc tgctgacggc tgggctgttg ccccggagtt cgctcggcaa
     7621 cctcgtggat gcctgcctgt cgctcggact cacccccttc gtggaggtca cgacagcgga
     7681 cgaggtggcg gctatcccgg atcctggcgg ctgtgtcgta gccgtcaaca acaaggacat
     7741 ccggaaccgg gaacggggcc cgggcgaccc cggtcgcagc ctggcgctgc tgccgcagct
     7801 gcgccgggct ggcgtggact gccgggtgag cgcgagcggg atcgaccagc cggcggtggc
     7861 ggtcggactg ctccaggcgg ggttcagcgc cctgctgatc ggcacatcgt tgctgcgggc
     7921 ggagcggctg tcggattggc tggcggagtt cgaccggggc tggtccgccg atcaggccgt
     7981 gctgagcagc ggctgagccc cgttcacccg aggttcggcc ggcacggcct ggccgacctc
     8041 ccggtgctcg ctggggctga ccccgcgcac ccgcttgaag gcggcgctca gcgcgtatgc
     8101 gctgctgtac ccgacctgtc gcgccaccga ggccaccgtg gcatcgctct cccggagcat
     8161 gtcggcggcg aggtccagtc gccagctgct gaggtaggtc atcgggcctt ctcccaccag
     8221 cgatgtgaac ctccgggcca aggcggcccg cgacacgccg accctcgccg ccaggttcgc
     8281 gaccgtccag gggtaggccg ggttcgcgtg gagaagccgg atcgcgggcc cgacgatcgg
     8341 gtcatgctgg gcgcggtacc agccggtgtc cggcgcatcc gaactggaca accattgccg
     8401 caacgcgctc accagcagta ggtcgagcag gcggtccagg atcagctcct ggccgggctc
     8461 gtcccttgcg atctcttggc tcaacagcgc gatccgtggt gcgtcgctcg gtttggtgcg
     8521 gccggtaagc accggcggga ggatgcggag caagcgctgg ctgacatcac catccagctg
     8581 gtaggtgccg ctgagcatga ccgcggcgcc ttcctgcgca tccccccagg tgcggacacc
     8641 cagtcgcatc gcctcggcca tgtctcgacc ttgcggcgta gtgcagcgct gtccagggtg
     8701 gatgacaatc tggacctcgc ggtccggctc gtcggccagg gtgtagcagt cggggccacg
     8761 gaagagcgcg acatcgcctc gggagagtct cgcgggttcg ccgccgtccg gcagaatcca
     8821 ggcatggccg tgcaccatcg tcacgaggca cagcggagcg cggtcgacca cccgcagcga
     8881 ccatggcggg gtgaggatcg agcgaagcac gaacgcccct ctcgcgcgaa gctggccgag
     8941 gagctctccg aacgcatcca tgctcttatc ctagacgctg gcatatggaa tcgagcgtga
     9001 gaacgatggc tcagttctcg gtggcgacaa tactgtgtag gcaaccagct cggcgcctac
     9061 ccaccacccg ctcggcgggc gccggaagga gggaaaagtg tcgggcttag cgcttattgt
     9121 ggcggtcgtt accactggtc tggtggcggg gattttcctc gggttctcga tatcggtcat
     9181 gcccgccctg gcccgcaccg gtgaccggac gttcgtcgag gtcatgcagc ggatcaacgc
     9241 cgcgattcag aatccactgt ttggcctggt gtttctgggg gcggtggtga gcatcggagt
     9301 cgctgggtgg cttcatgcct cccgggagga gatgttcagc tggattttag cgggagccgt
     9361 agggtacggc ctcaccctgc tgattacttt cgcgatcaac attccgctca acaaccgcct
     9421 tgatcgggcc gggccggcgg gtgggttggc gaatccacgc tcgccccgcc gagcgttcga
     9481 acgcctatgg gtcggtgccc accacgtccg gacgttgacc tgcgtcgccg ccttcggctg
     9541 tctgacactc gcgctcgcgg agctatgacc gcgtactcgc cggttggcgg agcgcgcccc
     9601 gccgaagccg accggttgtc gccgccgccg accccgagtg gcggcagcct actcgcgcag
     9661 attctgccgc cgcaggccca cggggtggag gcgtaccacg atgccccggc ggggtcgctg
     9721 tatcccgaag aggcagcgct gctggcccgg tccggcgccg gcgacaaacg gcgccgcgag
     9781 ttcacgacgg tccgcgcctg tgcccgggcc gccctgcacg agctgggcgt gccgccggcg
     9841 ccggtgttgc cgggccccgg gcgagccccc aactggccgg ccggcgtgac cggaagcatg
     9901 actcactgcg acggctaccg ggcggccgca gttgccgcca cggcggacct ccgcagcctg
     9961 gggatcgacg ccgagccggc cggcccgctg ccggccgggg tcctcggcct gatcggttcg
    10021 cgggcagagc gtgcgcaggt ggctcacctg gctcgggagc ggcccgaggt gccgtgggac
    10081 cggctgctct tctgcgccaa ggaggccgcc tacaaggctt ggtatccggt gaccgggcag
    10141 tgggtcgcgc tggccgacat cgcggtcgag gtcggcccgg aagatgggcg gctgcgagcc
    10201 cgcccacccg gaggcggcgc cctgcgcgag ttgcccggcc ggtgggcggt cgccgggcag
    10261 cgagaccgcg ccgggctgtt gctcgtcgcg gtgacggtgc gggtatgaac cagctccgga
    10321 gacggagacc ctcagcgagc cgccggctcg tcggctggct ggaccagcgg cacca
//
