LOCUS       NZ_CP070499            22589 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Natronosporangium hydrolyticum strain DSM 106523 chromosome,
            complete genome.
ACCESSION   NZ_CP070499
VERSION     NZ_CP070499.1
KEYWORDS    RefSeq.
SOURCE      Natronosporangium hydrolyticum
  ORGANISM  Natronosporangium hydrolyticum
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Natronosporangium.
REFERENCE   1  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Natrosporangium hydrolyticum gen. nov., sp. nov, a haloalkaliphilic
            actinobacterium from a soda solonchak soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) Bioinformatics, Leibniz Institute DSMZ,
            Inhoffenstr. 7B, Braunschweig 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-MAY-2020
            Assembly Method                   :: HGAP v. 4
            Assembly Name                     :: 999_Micromonospora_sp_DSM106523
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 580.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016925615.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 06:45:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,188
            CDSs (total)                      :: 5,131
            Genes (coding)                    :: 5,046
            CDSs (with protein)               :: 5,046
            Genes (RNA)                       :: 57
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 85
            CDSs (without protein)            :: 85
            Pseudo Genes (ambiguous residues) :: 0 of 85
            Pseudo Genes (frameshifted)       :: 18 of 85
            Pseudo Genes (incomplete)         :: 72 of 85
            Pseudo Genes (internal stop)      :: 4 of 85
            Pseudo Genes (multiple problems)  :: 8 of 85
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:11:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 758895
            Orig. end                         :: 781484
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070499.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22589
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="5"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22589
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22589
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12589](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12589)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            268..1845
                     /locus_tag="JQS43_RS03465"
                     /old_locus_tag="JQS43_03450"
     CDS             268..1845
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024108.4"
                     /locus_tag="JQS43_RS03465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03450"
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_239677610.1"
                     /transl_table=11
                     /translation="MTWLRGGSGRRGTGTPWSFLHSEYPAAASTLDQLLAHRALSDVDV
                     ARIGRLLTHAQADPARISAAAAEVMTAGAAAGLHRSAQHDLPGERLAQHNLEYGQVRLG
                     RVVPTAAGGFGATRDFGIDRDVLRTSLLVVGPPGSGKTRSFGLPVVEHLVLTALTNQAS
                     VLVVDPKGDDFAYAGWFDVTLDPLAPTAGLSLYGGSPAPEVAADRLASALLPPTTSDDV
                     AYFMDASRNALYACLAPFRLAFDRWPTVRELLALLRVEQGTVDKVRAALKGRDSGESRR
                     LLASRAAQRDARLDPAASMIERLGLLDRPRLVQLLDHQQPRFEMAQLNSPVRVRVALPE
                     SEYPDASRILARLLVSQFVQLTSAANTNRSIFKGLVIDEAGRFVDDYVARGVQKLRSNN
                     AGLVLIAQTLSDFPGHVRGTVLGSVGCKAVFGGVDPADAAVFSRWFGDHWVDEVTHGQQ
                     RSYSHSESRQGEQEGYRLGDSVSTRRVERPRWSVSEIVSGLPAGHCVVALSRSTGERSP
                     PFLVDLRG"
     gene            1954..2823
                     /locus_tag="JQS43_RS03470"
                     /old_locus_tag="JQS43_03455"
     CDS             1954..2823
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS03470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_03455"
                     /product="hypothetical protein"
                     /protein_id="WP_239677611.1"
                     /transl_table=11
                     /translation="MEDVVSAAADRLYAVPPRRFVAERTAAAATARASGDRAAASAITK
                     LRRPTVAAWLVNLLALRRPELVDGLVELAESLRGAQRRLDGAALRELAGQRRAAVSALV
                     SEARTLAVAADRESAAGALPLGEVETTLHAALAEPAVAEQVRSGRLLKGVAPTGFGAAA
                     PRLRLVTGAGAEEPPSDEPRSDEPPSGGSAAESSTVRRERAEAALGAARAAASQAEAAL
                     AARLAEQQAAQTAVAELDAALAELTARRQRAAEQLTDAEAAVFVARREEADARQRVAAA
                     AAELTGPD"
     misc_feature    2449..2451
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2868..3818
                     /locus_tag="JQS43_RS03475"
                     /old_locus_tag="JQS43_03460"
     CDS             2868..3818
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018745078.1"
                     /locus_tag="JQS43_RS03475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03460"
                     /product="YafY family protein"
                     /protein_id="WP_239677612.1"
                     /transl_table=11
                     /translation="MLESSARLLRLLSLLQSRRDWSGPELAQRLSVDVRTVRRDVDKLR
                     RLGYPIDATAGVAGGYRLGAGAALPPLLLDDEEAVAVAVGLRTAANGTVAGMAETSVRA
                     LAKLEQVLPVRLRQRVAAVQSVTVPMASGGPLVPAEVLTAVAAACRDEQQLRFDYRSFG
                     DTESVRNVEPYRLVHTGRRWYLLAWDLDRDDWRTFRLDRLRPWTPPGPRFAPRELPAAD
                     LAAFMSHQVSTAVYQLRATITVQASVAEVTERVPPTVGVVEPIDSASCRLTLGASHVDT
                     LVLHLGLLDFEFRVEDPPELAQRVRELSERLRRAA"
     gene            complement(3894..4178)
                     /locus_tag="JQS43_RS03480"
                     /old_locus_tag="JQS43_03465"
     CDS             complement(3894..4178)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012181201.1"
                     /locus_tag="JQS43_RS03480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03465"
                     /product="adhesin"
                     /protein_id="WP_239677613.1"
                     /transl_table=11
                     /translation="MLTVTDNAAAAIRSLTTQPDVPDGAGLRIATDASAGALQLSVSAG
                     PHEGDQVVDESGARLFLDGDAALLLDDKALDATVDDQGSVQFALAEQPQ"
     gene            complement(4500..6029)
                     /locus_tag="JQS43_RS03485"
                     /old_locus_tag="JQS43_03470"
     CDS             complement(4500..6029)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000030 - mannosyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006493 - protein O-linked glycosylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012180949.1"
                     /locus_tag="JQS43_RS03485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03470"
                     /product="phospholipid carrier-dependent
                     glycosyltransferase"
                     /protein_id="WP_239679294.1"
                     /transl_table=11
                     /translation="MPEITQRRLTPLVPPHDPWSWVVAAVVTTIAAIVRLVDLSRPGHI
                     VFDETYYAPNAWALVQYGVEWEVAEGGANPVDGAPVLGDGPAFVVHPPLGKWLIGLGEW
                     AFGYTPFGWRIAAALAGIISVLLVARIARRLFGSTMLGAAAGLLVALDGMHVVMSRTAL
                     LDIFLLLFVVAGFGALLLDRDQRRSRWLAALAAGRDRPGFGVPWWRLAAGALLGCALAV
                     KWSAVAFIPVFLGLALWWEVSARRTAGVRRPWRDTVAGQWRGFVAATVLIPVVYLATWI
                     GWFTSDHGFYRHAPVDAQGEPWPARVVAALRNLYEYHAQALTFHSGLDATHPYESPAWQ
                     WLLLARPIAFHYSDQGGCGAEHCASAVLLLGTPLLWWSFLPALAALVWLGVARRDWRAG
                     AILLGVAAGIGPWFLFDDRVMFYFYALPAQPFLVLAVVYVLGAVMSSARPRSTGDTGTI
                     LGVDRRTFGAVLVGGYVILVALTFAYFYPVYSAQLIPYESWQARMWLDTWI"
     gene            complement(6131..7120)
                     /locus_tag="JQS43_RS03490"
                     /old_locus_tag="JQS43_03475"
     CDS             complement(6131..7120)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014447093.1"
                     /locus_tag="JQS43_RS03490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03475"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_239677614.1"
                     /transl_table=11
                     /translation="MTYGITLPLPDVSLADHRELVAALPELGYTGVWSAEAGGADAFTP
                     LALASAWAPQLRLGTAIVPAFTRGAATLAQSCAALADAAPGRVAIGLGTSTEVIVSGWN
                     GLPFEQPYARVRDTVRFLRTALTGEKVTQRYESFEVSGFRLQLVPATPPALLVAALRPG
                     MLKLAGREADGAILNWLSVDDVATVAGQVHAAAPTGAAREIVARIFVVVDDDPVRARDT
                     ARPLLAGYLTVGVYRKFHEWLGRGELLAPLWEKWAAGDRRGAVAAIPDQVVDELVVHGS
                     PEQCRAHLRRYAAAGITTPVAALVPPRSGAPVSELVPALAPAADQQPG"
     misc_feature    7129..7146
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.64"
                     /tool="antismash"
     gene            7172..7975
                     /locus_tag="JQS43_RS03495"
                     /old_locus_tag="JQS43_03480"
     CDS             7172..7975
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (6-172). E-value: 9.6e-12. Score:
                     37.1. Matches aSDomain:
                     nrpspksdomains_JQS43_RS03495_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475993.1"
                     /locus_tag="JQS43_RS03495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03480"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_239679295.1"
                     /transl_table=11
                     /translation="MTLTGSVAVVTGGGSGIGAALARRFAAAGAATVVVADRDPAAAAT
                     VAAELPGAGAPLALDVADEAAVAAAVDQLESEVGPIDLWCSNAGVAGSEGLGDDADWQR
                     CWSLHVHAHVLAARHVLPRMLARDRGHLLVTASAAGLLTEPDSAPYAVTKHASVALAEW
                     LAIQHGGAGVSFSCLCPQAVRTPMVAGLPDTSGTLAAGEIISPEQVADSVMAALAEQRF
                     LILPHPEVAAYEQRRAAQRERWLAGMRKVRARLRRPPEQPAPPRR"
     aSDomain        7190..7687
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQS43_RS03495_PKS_KR.1"
                     /evalue="9.60E-12"
                     /label="JQS43_RS03495_PKS_KR.1"
                     /locus_tag="JQS43_RS03495"
                     /protein_end="172"
                     /protein_start="6"
                     /score="37.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGGGSGIGAALARRFAAAGAATVVVADRDPAAAATVAAELP
                     GAGAPLALDVADEAAVAAAVDQLESEVGPIDLWCSNAGVAGSEGLGDDADWQRCWSLHV
                     HAHVLAARHVLPRMLARDRGHLLVTASAAGLLTEPDSAPYAVTKHASVALAEWLAIQHG
                     GAG"
     CDS_motif       7196..7285
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQS43_RS03495_0001"
                     /evalue="1.20E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="JQS43_RS03495"
                     /protein_end="38"
                     /protein_start="8"
                     /score="24.4"
                     /tool="antismash"
                     /translation="VVTGGGSGIGAALARRFAAAGAATVVVADR"
     CDS_motif       7541..7666
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQS43_RS03495_0002"
                     /evalue="4.10E+00"
                     /label="PKSI-KR_m1"
                     /locus_tag="JQS43_RS03495"
                     /protein_end="165"
                     /protein_start="123"
                     /score="0.2"
                     /tool="antismash"
                     /translation="MLARDRGHLLVTASAAGLLTEPDSAPYAVTKHASVALAEWLA"
     gene            8019..9812
                     /gene="metG"
                     /locus_tag="JQS43_RS03500"
                     /old_locus_tag="JQS43_03485"
     CDS             8019..9812
                     /EC_number="6.1.1.10"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004825 - methionine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006431 - methionyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018221224.1"
                     /locus_tag="JQS43_RS03500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03485"
                     /product="methionine--tRNA ligase"
                     /protein_id="WP_239677615.1"
                     /transl_table=11
                     /translation="MAHVLAAVAWPYANGPRHIGHVSGFGVPSDVFARYQRMAGNDVLM
                     VSGTDEHGTPILVQAEQEGASARELADRYNRVIVEDLAALGLSYDLFTRTTTGNHYAVA
                     QELFATLHRNGYMVERKTHGAISPSTGRTLPDRYIEGTCPLCGYDGARGDQCDNCGNQL
                     DPTDLINPRSRVNGEVPKFIETEHFFLDLPALGEALGDWLRGRADWRPNVLKFSLNLLD
                     DLKPRAMTRDIDWGVPVPLPGWRENPNKRLYVWFDAVIGYLSASIEWARRSGDPEAWRR
                     WWSDPAARQYYFMGKDNITFHSQIWPAELLGYNGQGARGGEPGRFGELHLPTEVVSSEF
                     LTMEGAKFSSSRRVVIYVRDFLARYDPDALRYFIAVAGPENNDTDFTWSEFLRRNNDEL
                     VAGWGNLVNRSISMAAKNFGSVPEVGAAGLTDADQRLLATAREGFGTVGGLIERHRQKA
                     AITEAMQVVGEANKYLSDQAPWKLKETDRQRMGTVLNVALQVVNDCNAMLSPFLPHSAQ
                     KVYEQLGGAGRFAPMPEIQEVEDLDGGAGYPVLAGDYQTGASWAPQSLPPGRELAPPKP
                     VFKKLDAGIVDEELARLAGDQ"
     CDS             complement(9864..10001)
                     /gene="allorf_0768759_0768896"
                     /locus_tag="allorf_0768759_0768896"
                     /protein_id="allorf_0768759_0768896"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MNNVLALQQLPAEPEEPAGPHTGPSYPWSVYSIPIPGNPTRICED
                     "
     CDS_motif       complement(9936..10001)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNNVLALQQLPAEPEEPAGPHT"
                     /locus_tag="allorf_0768759_0768896_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9864..9935)
                     /prepeptide="core"
                     /locus_tag="allorf_0768759_0768896_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-2.90"
                     /molecular_weight="2476.7"
                     /monoisotopic_mass="2475.2"
                     /core_sequence="GPSYPWSVYSIPIPGNPTRICED"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNVLALQQLPAEPEEPAGPHT"
                     /leader_location="[9935:10001](-)"
                     /alternative_weights="2494.8"
                     /alternative_weights="2512.8"
                     /alternative_weights="2530.8"
     gene            complement(10001..12589)
                     /gene="lanKC"
                     /locus_tag="JQS43_RS03505"
                     /old_locus_tag="JQS43_03490"
     CDS             complement(10001..12589)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="JQS43_RS03505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03490"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_239677616.1"
                     /sec_met_domain="micKC (E-value: 7.4e-142, bitscore: 472.3,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.2e-08, bitscore: 32.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3e-10, bitscore: 37.7,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLTTVSYTLADPDYYEPRHRHQDNSRPLRPSSPPVGWRSSRHDV
                     WLSWEPPSGPPLPAQGWKIHVSATLPGASRVLDSVTAACATATVSFKHLASEFAFLLMG
                     HKHGVRSQAGKFCTLYPATESAARQLLTELAGALVDEPGPYILSDRRFGDSRTVHYRYG
                     AFQARTRVTLDGRAVPLLTNGSGQWVEDLRSHQFMLPEGVTDPFLAKAPAPAQTDGGVM
                     IGGYRATAALAQSNAGGAYRAVAASGRPVFLKEARAHTGFHWDGSTASQRLHREHRVLG
                     DLHTRAPGLAPEPIELFREWEHDFLVTELVPGSSLFGYAARRNPYLQEGSPAEFESYFH
                     ACLDYLAQLNRALQRLHELGYRFGDVNPRNVLITDDGQVRLIDFESCNRLDQPPIDLGA
                     PGYLPPDPHARAGTGADDYGLSAVALTMLAPVHQQLVRNPAAVAHLAAHLNRRHPVPPS
                     LWQLATRHLPTPGGNAGGAPVTPAPVELAADPIRHLRRLRDAIGRELVATAAPDDPDRI
                     WPTVPEGYTTNTWNLAHGAAGVLHALHHAGLPADPRSVARFRSEALARRAEFPPGLHYG
                     LAGIAAVLGEYGQLDEALTLVEAARTHHLTRTAGSWSGGSAGVGTALLTLHARTGEAAL
                     LAQAVELGDQLVMAEAAELLGPDNPTGLLNGRSGMALFLHQLWRATDAKHYLEVGRQLL
                     VDELGRGVEIRGHLMFPDDDATPRMMPYLGIGSAGVALVLTRYRHADDTDERLATASAA
                     VLAGAHQPVTVESGLYLGLAGLVFAHAEHADLAGASDPSAGATAQRLAAGLVAYAAPGP
                     AGRSRVLGSGRLRFSCDLGTGAAGVLLALHRILAGPTGQLFISTTTREVN"
     gene            12897..13241
                     /locus_tag="JQS43_RS03510"
                     /old_locus_tag="JQS43_03495"
     CDS             12897..13241
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS03510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_03495"
                     /product="hypothetical protein"
                     /protein_id="WP_239677617.1"
                     /transl_table=11
                     /translation="MRPHIAGWRTPLALLLSLALTATLIGPAVGAPGAADAALTVGSVA
                     AAQLWISYDDGGSWSPQSVQPSGEGSFHTNLPTPPLDHSGFGSIRVVASDVEGNQIDQE
                     VIRAWRVPAP"
     gene            13325..13675
                     /locus_tag="JQS43_RS03515"
                     /old_locus_tag="JQS43_03500"
     CDS             13325..13675
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS03515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_03500"
                     /product="hypothetical protein"
                     /protein_id="WP_239677618.1"
                     /transl_table=11
                     /translation="MSFLSVLPGVVGAAGSRTAMTAGDWSGWAQHSETMLRNAGGGCRS
                     GKLSSAFDSYLAQLRPCLQNQAVRASALGGNAASAASAVDQADGDSSGVLGGQVGNLVS
                     QASVLARQINFG"
     gene            13708..14943
                     /locus_tag="JQS43_RS03520"
                     /old_locus_tag="JQS43_03505"
     CDS             13708..14943
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS03520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_03505"
                     /product="hypothetical protein"
                     /protein_id="WP_239677619.1"
                     /transl_table=11
                     /translation="MEPFEKHQADVGELHAASSGLLADASQAGDNVSLTTHAYQPVIDD
                     WQGLGAGEAQGAPQPLRAGADQASTSLAWAAVVTEFWAGKVETFNSEVDKIVERYESQG
                     PRYGVTGDDPDDDEIEQARLDALAKAREQWWEAYNTHILDGEDQAAAMLADGPTEANLS
                     VAKRFFDGMDWFTRNIGPAMPWIMSELFFGGRWAHHRWWTRHYLIWAQRYVDGRWAGGV
                     PDAKGAARLVTTALRESGHGQRMRQMATWASRLSLVTAGGAAAGFQWYDDRNTGYTTEY
                     RVARAGIAGGMTAGFAAAGGLLGAAAGAGLGPKGVVVGSVVGSTLGGIAGGWASDRAID
                     SLDYVIDHAAGSAPGSSGGVRDGAAAYVGAAAGNLTELSNLGRWAVPGSSGTPEADPTQ
                     VRDDVTNWLAGR"
     gene            14962..15444
                     /locus_tag="JQS43_RS03525"
                     /old_locus_tag="JQS43_03510"
     CDS             14962..15444
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS03525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_03510"
                     /product="hypothetical protein"
                     /protein_id="WP_239677620.1"
                     /transl_table=11
                     /translation="MHAAKAEEMVQYKHPRAGFSVPVPREWERAVDTAEVPLIVAAPPD
                     PPWRFRANLIVTVDQLGPEVTVAARHAANIEGLHRALTRFRLLDQEESRLRGCPLLRTL
                     GHHAAEAGAVTFEQWIYIGEEHCFALTASVGTLEYPAYREIFAAMVYEFRLPQEVS"
     gene            15441..16292
                     /locus_tag="JQS43_RS03530"
                     /old_locus_tag="JQS43_03515"
     CDS             15441..16292
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025377.4"
                     /locus_tag="JQS43_RS03530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03515"
                     /product="ESX secretion-associated protein EspG"
                     /protein_id="WP_239677621.1"
                     /transl_table=11
                     /translation="MTVSFDPVNGRLRLDDVSFAVLRDLVRQDSTEQLDGHHLAELRDS
                     GVVRGCIPHPSLAYGLDAVAVPVCRLTLRVDTPETDVLRTRHVAGWLGRDAMAVLRDDD
                     DGLREFRTQPVTLLPELVATETEFGPRPRPPELFFAVPADVWEELVTTVNGRAEREQAM
                     LRFVDAAAEAGPAAADAARRLVTSLRRRWEVAVRWRPAPGAVGERSLQVVDAQVGLWRV
                     TTGPGAVTLSATTPTVVWQEIIGLLPQDDELAAPESEPARAGSAAAGGGLESWQGEWSG
                     RG"
     gene            16270..17151
                     /locus_tag="JQS43_RS03535"
                     /old_locus_tag="JQS43_03520"
     CDS             16270..17151
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014694735.1"
                     /locus_tag="JQS43_RS03535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03520"
                     /product="TatD family hydrolase"
                     /protein_id="WP_239677622.1"
                     /transl_table=11
                     /translation="MSGADADERRQRAAGRGEHEAPPAPEPLPLPVVDSHTHLDLVSDA
                     GGGDPAAQLAAAAAVGVDRVVQVGVDLPSSRWASQLAAEHPQVLATVGVHPNEAPRLGD
                     GLDEALREVERLAAAPRVRGVGETGLDTFRTGPEGAAAQEASFRGHIAIAKRFGKALII
                     HDREAHAEVLRVLDDEGAPDRVVMHCFSGDAEFADECLRRGFVLSFAGTVTFRNARSLR
                     EAARRCPPDRLLVETDAPYLTPHPYRGRRNGPYLIPVTVRGLAEARGVELAPLCRAISD
                     TGEWVFGGWGGA"
     gene            17148..18011
                     /gene="rsmA"
                     /locus_tag="JQS43_RS03540"
                     /old_locus_tag="JQS43_03525"
     CDS             17148..18011
                     /EC_number="2.1.1.182"
                     /GO_function="GO:0000179 - rRNA
                     (adenine-N6,N6-)-dimethyltransferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsmA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018729488.1"
                     /locus_tag="JQS43_RS03540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03525"
                     /product="16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-
                     dimethyltransferase RsmA"
                     /protein_id="WP_239677623.1"
                     /transl_table=11
                     /translation="MTGLLGPAQLRELADRLGVRPTKQRGQNFVVDANTIRRIVTAAGL
                     DPADVVLEVGPGLGSLTLGLLPACRHVHTVEVDPVLAAALPETVHGWAPEYADRFTGHL
                     ADALTLSELPEPAPTALVANLPYNVAVPVVLHLLAVVPTLRHGLVMVQQEVADRLTAGP
                     GSRVYGVPSAKLAWYAQARPAGRVPRTVFWPAPNVDSGLVAFARREPPAGPARTAVFAV
                     VDAAFGQRRKMLRTALAGWAGGAARAEALLDIAGVPAQARAESLTIEQFAAIAAAATTA
                     AEGTTQ"
     gene            18020..18967
                     /locus_tag="JQS43_RS03545"
                     /old_locus_tag="JQS43_03530"
     CDS             18020..18967
                     /EC_number="2.7.1.148"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0050515 - 4-(cytidine
                     5'-diphospho)-2-C-methyl-D-erythritol kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011904694.1"
                     /locus_tag="JQS43_RS03545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03530"
                     /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
                     kinase"
                     /protein_id="WP_239679296.1"
                     /transl_table=11
                     /translation="MWADDEYDQPKPAGTGAVRVRVPAKVNLHLGVGEVRPDNYHELQT
                     VYHAISLFDEVTARPGDTLALTMAGEGAGELALDDSNLVLRAARALAEHADVPAHARLH
                     LRKQIPLAGGLAGGSADAAATLVACDALWDLGLSREELAGLAAGLGADVPFLIYGGTAL
                     GIGRGEQVSPVLARPGVWHWVVGFHDGGLATPEVYQELDRLRAADAAPAPLPEPAGLLA
                     ALRQRDPEVLGAALGNDLAAAARSLRPELSAVLAAGEAAGALAGLISGSGPTCVFLARH
                     AEHAAEVAAALTGAEVCRAVRTCHGPVPGARVQH"
     gene            complement(19005..22061)
                     /locus_tag="JQS43_RS03550"
                     /old_locus_tag="JQS43_03535"
     CDS             complement(19005..22061)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020515971.1"
                     /locus_tag="JQS43_RS03550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_03535"
                     /product="AAA family ATPase"
                     /protein_id="WP_239677624.1"
                     /transl_table=11
                     /translation="MPGLATGTPEPTTPGFAAPALVGREAEVAALLRTLTEPALVLVEG
                     EAGIGKSRLLREFAAASGDRRLLWCACPPHPEPLLLAPLVDALQRHRAEVPDLPLSALA
                     GALRPLFPRWADRLPPPPEPLPDLKATRHRLFRALAELLGQLSFQAIVVEDVHWADVAT
                     LEFLLFLAGRAATAHRLTGTGGTPGPPGQAASLIVSYRPADVPPDSLLLRLSSRPSAGN
                     RQLRIPVPALDTAGTARLASSMLPGEPISEDLADFLHQHTEGVPLAVEESVRLLRDRGD
                     LVRRGGEWVRQRLPELTVPPTIRDTVLARIPRLSASAQQVLAAAAVLAAPATEAVIARV
                     AAADTQPDPDAQSDPDAWFDQVRRGLGEAIAGGLLREEGDQRSSFRHVLMGQAVYESLP
                     AARRRALHLAAGTALAEAGTAPPAALARHFKQARQPARWMRYAELAADQAGESGDYDAA
                     VALLLDALAAPNRSIDDQVRLGRRLALAASYRREAVDELHQRAVETLRRLLADTTLSPT
                     EDAELRSGFGRLLAQLGEFGPARAEIGRAVSQLDHHPVEAARAMRFLGLPFVGDEPATV
                     HRRWLQRAAGVDLARLPAAERLALTVDRAAGLLQLGDPAGWAVADELPATVLGAAGRTA
                     EERRQVARGYLNIGAAAILWGRYRHAEQLLNQAAELADADRYLRLGPLIRISQAQLEWY
                     TGQWAGLTEHVTTAADPSSDEPLALLGAVRVGLWHLAQGSHRRAEAALRQALAEVARIG
                     TVDDGLEPAAALGRLALSRGQVDDALAYTERPMATVAGKGIWIWATELAPVRVAALLAA
                     GRLSEAEELVNAYQRGMRRCPAPAGRAALATCRALLAAATGPAPAAAGRFAVAARAWEE
                     LPRPYEALLAREQQAVAELAGDRQAAALTRLGTTFQALSELGARGDAERVGELLRAHGV
                     DARREWRRGRRGYGDRLSPRELDVVRLVATGATNREVAAALSRSPKTVAGQLSSAMRKL
                     GVTSRTELAVDTVRNRLLPDPPVPDQAEP"
     misc_feature    complement(19041..19043)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(20868..20870)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gctgccggtg gtggcgatgg cgccgttcct ggtgctggcc ggccgccgcg tcggcggcgc
       61 cgagcgacgg gcggatgaga tcgcggtggt cctcggctat ggggccgaac tgttggccgc
      121 attggccgat tcggcgcccg ccaatcagga ggcgagtcgc tggcgcgtag cgacgccgca
      181 gcagtccgcg atcgcggcac gtcgccgccg gttggcgcag cggctcgggg cgcgagggtg
      241 aggcgagggg gaggcgaggg tgaggcgatg acctggctac gaggaggctc cgggcgtcgc
      301 ggtaccggga cgccgtggag tttcctgcat agcgagtacc cagcggccgc gagcacgctc
      361 gaccagctgc tggcgcatcg agcgctctcc gacgttgatg tcgcgcggat cggcagacta
      421 ctgacgcacg cgcaggcgga tcccgctcgg atcagcgcgg cggcggccga ggtgatgacg
      481 gccggggcgg ccgccgggct gcaccgttca gcccagcatg acctgccggg cgagcggctt
      541 gcccagcaca atctggagta cggtcaggtc cggctggggc gggtggtgcc caccgcggct
      601 ggtgggttcg gggcgactcg cgatttcggt atcgaccggg atgtactccg aacctcgctg
      661 ctggtggtgg ggccgcccgg ctccggaaag acccggagct tcgggctgcc ggtcgtcgag
      721 catctggtcc tcaccgcgtt gacgaaccag gccagtgtgc tggtggtgga cccgaagggt
      781 gacgacttcg cgtatgcagg ctggttcgat gtcacgctcg acccgctggc gccgaccgcc
      841 gggctgagcc tctacggcgg ctccccggcg cccgaggtcg cggctgatcg gctcgccagc
      901 gccttgttgc caccgacgac atctgacgat gtcgcctact tcatggatgc ctcccgcaac
      961 gctctgtacg cgtgcctggc gccgtttcgg ctggccttcg accggtggcc gaccgtacgg
     1021 gaactgttgg cgttgctgcg cgtggagcag ggcacagtgg acaaagttcg agctgccttg
     1081 aagggccggg acagcggcga gagccgtcgg ctgctggcca gccgcgccgc ccaacgggac
     1141 gcccggctgg atccggccgc atcgatgatc gaacggctcg gcctgctgga ccgccctcgg
     1201 ctggtgcagc tccttgacca ccagcaaccc cggtttgaga tggcgcagct gaactccccg
     1261 gtccgggtgc gggtggcgct gccggagtcg gagtacccgg acgcctcgcg gatcttggcg
     1321 cggttgctgg tctcccagtt cgttcagctc acgtcggccg cgaacaccaa ccggtcgatc
     1381 ttcaagggcc tggttatcga cgaggccggc cggtttgtgg acgactatgt ggcccgcggc
     1441 gtgcagaaac tgcgatcgaa caacgccggc ctggtgttga ttgcccagac cctcagcgac
     1501 ttccctggcc atgtccgggg gaccgtactc gggtcagtgg ggtgcaaggc ggtattcggt
     1561 ggggtcgacc ccgccgacgc cgcggtgttc tcccgatggt tcggcgacca ctgggtcgac
     1621 gaggttaccc atggtcagca gcgttcctac agccacagcg agtcgcggca gggtgagcag
     1681 gagggctacc gcctgggcga cagcgtcagc acgcggcggg tggagcggcc gcgctggagc
     1741 gtctcggaga tcgtgagcgg gctgccggcg gggcactgcg tggtggcgct gagccgctcc
     1801 accggcgaac ggagcccgcc gttcctggtc gacctgcgcg gctgaggacg gcccagcggc
     1861 gcgcggtggg ccgtcctgtc cggggggagg gctcagccgg cgcgcggtgg gtcgcaccgc
     1921 tcgcgccgcg tcctggtgcg gcaccatgaa ggggtggaag acgtggtgtc cgcagccgcg
     1981 gaccggttgt acgcggtgcc gccgcgccga ttcgtagcgg agcggaccgc ggcggcggcg
     2041 accgcccgag ccagcggcga ccgggccgcg gcctccgcca tcaccaagct gcgccggccc
     2101 acggtggcgg cgtggttggt gaacctgctg gcgctgcgcc gccccgagct ggtcgacggg
     2161 ctggtggagc tggccgagtc gctgcggggg gcgcagcgca ggttggacgg cgccgctctg
     2221 cgggagctgg ccggtcagcg ccgcgcggcg gtcagcgccc tggtgtccga ggcgcgcacc
     2281 ctggcggtgg ccgccgaccg ggagtcggcg gccggcgcgt tgccgttggg tgaggtggag
     2341 acgacgctgc acgcggcgtt ggccgagccg gccgtggccg agcaggtgcg ctccggtcgg
     2401 ctgttgaagg gggtggcgcc gaccgggttc ggtgcggcgg ccccgcggtt acggctggtc
     2461 accggcgccg gggcggagga gccaccctcg gacgagccac gttcggacga gccgccctcg
     2521 ggcgggtcgg cggcggagtc gagcaccgtc cgccgggagc gggccgaggc ggcgttgggc
     2581 gcggcgcggg cggccgcgtc gcaggccgag gcggcgctgg ccgcgcggct ggcagagcag
     2641 caggcggccc agacggcggt ggcggagctc gacgccgcgc tggcggagct caccgcccgc
     2701 cggcagcgag ctgccgagca gctgaccgac gccgaggcgg cggtcttcgt cgcccggcgc
     2761 gaggaggcag acgcccggca gcgggtcgcc gccgcggcgg cggagctgac cgggccggac
     2821 tagacccgcg ggccggaact gtcctggtcc ccgggcagaa tggtggtgtg ctggagagct
     2881 ctgcccggtt gctgcggctg ctgtcgttgc tgcagagccg ccgggactgg tccggccccg
     2941 agttggcgca gcggctgtcg gtggatgtgc gcacggtgcg gcgcgacgtg gacaagctcc
     3001 ggcggctggg ctatccgatc gacgcgaccg ccggggtggc gggtggctac cggttgggcg
     3061 cgggcgccgc cctgccgccg ctgctgctcg acgacgagga ggcggtggcg gtcgcggtgg
     3121 ggctgcggac cgcggccaac ggcacggtcg ccggcatggc cgagacttcg gtacgggcac
     3181 tggccaaatt ggagcaggtg ctgccggtgc ggctgcggca gcgagtggcc gcggtgcaat
     3241 cggtgacggt gccgatggct agtggcggac cgttggtgcc ggccgaggtg ctgaccgctg
     3301 tcgccgcggc gtgccgggat gagcagcagc tccggttcga ttaccggagc ttcggcgata
     3361 ccgagtcggt tcgcaatgtg gagccgtacc ggttggtcca caccgggcga cggtggtatc
     3421 tgctggcgtg ggatctagac cgcgacgatt ggcggacctt ccggctggat cggctgcgac
     3481 cttggactcc gccggggccc aggttcgctc cgcgggagct gcccgccgcc gatctggccg
     3541 ccttcatgtc ccaccaagtg tccactgcgg tctatcagct gcgggctacg atcactgtgc
     3601 aggcttcggt ggcggaggtc accgagcggg ttcccccgac ggtcggagtg gtggagccga
     3661 tcgactcagc gagctgccgg ctgacgctcg gggccagtca tgtcgacacc ctcgtcttgc
     3721 acttgggctt gttggacttc gagttccggg tagaggaccc gcccgagttg gcgcagcggg
     3781 tccgggaact ctccgaacgg ttgcgtcggg ccgcgtaacc ggccagccgg tgggtcaccg
     3841 actggccggt gtgccgccgc ggcgggctca cccggcggtg gcccaccgcc gtcctactgg
     3901 ggttgttcgg cgagcgcgaa ctgcacgctg ccctggtcat cgacggtggc gtcgagggcc
     3961 ttgtcgtcga gcagcagcgc ggcgtccccg tcgaggaaca gccgggcgcc ggactcgtcg
     4021 acgacctggt ccccctcgtg tgggccggcc gagacgctca gctgcagcgc ccccgccgaa
     4081 gcgtcggtgg cgatgcgcag gccagcgccg tccggtacgt ccggctgagt ggtcagcgaa
     4141 cggatcgcgg cggcggcatt gtcagtcact gtaagcatgg cggattgctc ctccggttgc
     4201 gattgatggc acgggaccct ccaacccctg atacccactg cggcacgtgg ctacgcaagt
     4261 cagtgggcag gttgtggatc cgttctgggc acggccgaac caccactggt ggccagtgcc
     4321 cgcgacggca aagaactcct ctcggcacgt cgacccgaac tcggcacgcg tggcctcaca
     4381 gcccacacgt gtctagtcga cgcgcacgcg ttgacagccg taccgtccca ccctgcctgc
     4441 tcggcccggc ctgcgtcaag ccgacatgcg accacaagcc gacagtcgtc gcggggtggt
     4501 cagatccacg tgtccaacca cattcgggcc tgccagctct cgtaaggaat gagctgggcg
     4561 gagtagaccg gatagaagta cgcgaaggta agcgcgacca ggattacgta cccgcccacc
     4621 agtaccgccc cgaacgtgcg acggtccact cccagaatcg tgccggtgtc accggtcgaa
     4681 cgtggccggg ccgacgacat caccgcaccc aacacataga ccacggcgag caccaggaac
     4741 ggttgtgcgg gcagggcgta gaagtagaac atcacccggt cgtcgaagag gaaccatggt
     4801 ccgatccccg ccgccacgcc gagcaggatc gcccctgccc gccagtcccg gcgcgccacc
     4861 ccgagccaga ccaacgccgc caacgccggc aggaatgacc accacagcag cggcgtaccc
     4921 agtagcagca ccgccgaggc acagtgctcc gcgccgcagc caccctgatc ggagtagtgg
     4981 aaggcgatcg ggcgcgccaa caacagccac tgccacgccg gcgactcgta cgggtgagta
     5041 gcgtcgaggc cagagtggaa cgtcaacgcc tgggcgtgat actcgtagag gttgcgcagc
     5101 gccgcgacca cccgcgccgg ccacggctcg ccctgcgcgt cgaccggcgc gtgccggtag
     5161 aagccgtgat cactggtgaa ccagccgatc caggtcgcca gatacaccac cggtatgagg
     5221 accgtcgcgg cgacgaaacc gcgccactgc ccggcgacgg tgtcccgcca cggccggcgt
     5281 accccggcgg tacgtcgggc cgaaacctcc caccacagcg cgagccccag gaagaccggg
     5341 atgaacgcga ctgcgctcca cttcaccgcc agcgcgcagc cgagcagggc accggccgcc
     5401 agccgccacc acggcacccc gaacccgggc cggtcccggc ccgccgccag cgccgccagc
     5461 caccgggagc ggcgctgatc ccggtccagc agcagcgccc cgaacccagc cacgacgaag
     5521 agcagcagga agatgtcgag cagcgcggtc cgcgacatca ccacatgcat gccgtccagc
     5581 gcgaccagca ggccggcggc ggccccgagc atggtggagc cgaacagtcg ccgggcgatc
     5641 cgggccacca gcagcaccga gatgattccg gcgagcgcgg cggcgatccg ccagccgaac
     5701 ggggtgtagc cgaaagccca ctcgcccagt ccgatcagcc acttacccag cggcggatgg
     5761 accacgaagg cgggcccgtc gccgagcacc ggggcgccgt cgaccgggtt ggccccaccc
     5821 tcggcgacct cccactccac gccgtactgc accagtgccc aggcgttcgg ggcatagtag
     5881 gtctcgtcga agacgatatg gccggggcgg ctcagatcga ccagccgcac gatcgcggcg
     5941 atcgtggtga ccaccgcggc gaccacccac gaccagggat cgtgcggcgg gaccagtggg
     6001 gtcagccgcc gctgggtgat ctccggcacc ggttcatccg ccgggctcgg ccccgcctcg
     6061 gtcgccaccg tactcaccgg tgcatcgtag gccgtcagtc gcccccgtgg tgacggcgcg
     6121 tacccgatcg ttagccgggc tgctggtcag cggcgggggc gagcgccggc acgagttcgg
     6181 agaccggggc gcccgaccgg ggcggcacca gcgccgccac cggggtggtg atccccgccg
     6241 cggcgtatcg tcgcaggtgc gcgcggcact gctccggcga accgtgcacc actagctcgt
     6301 ccaccacctg gtctgggatc gccgcgaccg cgccgcgccg gtcgccggcg gcccacttct
     6361 cccacagcgg cgcgagcagt tcgccgcgcc ctagccactc gtggaacttc cggtacaccc
     6421 cgacggtcag gtagccggcg agcagcggcc gggccgtgtc ccgggcccgg accgggtcgt
     6481 cgtcgaccac cacgaagatc cgggcgacga tctcccgcgc ggcgccggtc ggcgcggcgg
     6541 cgtggacctg accggcgacc gtggccacgt catcgacgct gagccagttc aggatcgccc
     6601 cgtcggcctc ccggccggcc agcttcaaca tgcccggccg cagcgccgcg accagcagcg
     6661 ccggcggggt ggccggcacc aactggagcc ggaaaccgga gacctcaaag ctctcgtacc
     6721 gttgcgtgac cttctcgccg gtgagcgcgg tacgcaggaa gcggaccgtg tcgcggaccc
     6781 gggcgtacgg ctgctcgaag gggaggccgt tccacccgct gacgatcacc tcagtggagg
     6841 tgccgagccc gatcgcgacc cggcccgggg ccgcgtcggc gagcgcggcg cagctctgcg
     6901 ccagcgtcgc ggcaccgcgg gtgaaggccg ggacgatcgc ggtgccgagc cggagctgcg
     6961 gtgcccacgc actggcgagc gcgagcgggg tgaaggcgtc ggcgccgccg gcctcagccg
     7021 accacacccc ggtgtagccg agctcgggca gcgccgcgac cagctctcgg tggtcggcca
     7081 acgagacatc ggggagcggg agggtgatgc cgtaggtcat acggcggtat gttaccagtc
     7141 agtagccagt ttgggaggtg tgcgcgggat ggtgacattg accggctcgg tggcggtggt
     7201 gaccggcggc ggcagcggca tcggggcggc gttggcccgg cggttcgcgg cggccggcgc
     7261 cgccacggtg gtggtcgccg accgcgaccc ggccgcagcg gccacggtcg ccgccgagtt
     7321 gcccggcgcc ggggcgccgc tggcgttgga cgtcgccgac gaggcggcgg tcgccgccgc
     7381 cgtcgaccag ctcgagtcgg aggtcggccc gatcgacctg tggtgctcga acgccggcgt
     7441 ggccggctcg gaggggctgg gcgacgacgc ggactggcag cggtgctggt cgctgcacgt
     7501 gcacgcgcac gtgctggcgg cgcgccatgt gcttccccgg atgctcgccc gcgaccgcgg
     7561 ccatctactg gtcaccgcct cagccgccgg cctactgacc gagccggaca gcgccccgta
     7621 cgcggtgacc aagcacgcca gcgtcgccct cgccgagtgg ctggcgatcc agcacggcgg
     7681 tgccggcgtg agcttctcct gcctgtgccc gcaggcggtg cggaccccga tggtcgccgg
     7741 cctgcccgac acctccggaa ccctcgccgc gggcgagatc atctcaccgg agcaggtggc
     7801 cgactcggtc atggccgccc tggccgagca gcggtttctg atcctgccgc acccggaggt
     7861 ggccgcgtac gagcagcgtc gggcggcgca acgggaacgc tggctggccg gtatgcgtaa
     7921 ggtccgggcc cggctgcgcc ggcccccgga gcaacccgcc ccgccgcgcc ggtaaccgga
     7981 gtgcgccctg gcgggggtag tcactacgct tgggctccat ggcccacgtt ctagctgccg
     8041 tcgcctggcc gtacgccaac ggcccgcgac acatcggtca cgtctccggc ttcggggtgc
     8101 cctccgacgt cttcgctcgc tatcagcgaa tggccggtaa cgatgtgctg atggtctccg
     8161 gcaccgacga acacggcacg ccgatcctgg tgcaggccga gcaggagggc gccagcgccc
     8221 gggagctggc cgaccggtac aaccgggtga tcgtggagga cctggcggcg ctggggctgt
     8281 catacgacct gttcacccgg accaccaccg gcaaccacta cgcggtggcg caggagctct
     8341 tcgccaccct gcaccgcaac ggctacatgg tggagcgcaa gacccacggg gcgatctcgc
     8401 cgtccaccgg gcggacgctg cccgaccgct acatcgaggg cacctgcccg ctctgcggct
     8461 acgacggggc ccgcggcgac cagtgcgaca actgcggcaa ccagctcgat ccgaccgatc
     8521 tgatcaaccc tcggtcccgg gtcaacgggg aggtgccgaa gttcatcgaa accgagcatt
     8581 tcttcctgga tctgcccgcg ctgggggagg cgttgggcga ctggctgcgc ggccgcgccg
     8641 actggcggcc gaacgtgctg aaattctcgc tgaacctgct cgacgacctg aagccacggg
     8701 cgatgacccg cgacatcgac tggggcgtgc cggtgccgct gccagggtgg cgggagaacc
     8761 ccaacaagcg gctgtacgtg tggttcgacg cggtcatcgg ctatctttcg gcgtcgatcg
     8821 agtgggcccg ccgttccggg gacccggagg cgtggcgccg gtggtggtcg gacccggccg
     8881 cccggcagta ctacttcatg ggcaaggaca acatcacctt ccactcccag atctggccgg
     8941 cggagctgct cggctacaac ggccagggcg cccgcggcgg cgagccgggc cggttcggtg
     9001 agctgcacct gccgaccgag gtggtctcca gcgagttcct caccatggag ggggcgaagt
     9061 tctcctcgtc gcggcgagta gtcatctacg tccgcgactt cctggcccgc tacgacccgg
     9121 acgcgctgcg ctacttcatc gccgtcgccg gccccgaaaa caacgacacc gacttcacct
     9181 ggtcggagtt cctccgccgg aacaacgacg agctggtcgc cggctggggc aacctggtca
     9241 accggtcgat ctcgatggcg gcgaaaaatt tcggctcggt gccggaggtc ggtgcggccg
     9301 gtctcaccga cgccgaccag cggctgctcg cgaccgcccg ggagggtttc ggcacggtcg
     9361 gcgggctgat cgagcggcac cggcagaagg ccgcgatcac cgaggcgatg caggtggtgg
     9421 gcgaggccaa caagtacctc tccgaccagg caccctggaa gctcaaggag accgaccggc
     9481 agcggatggg caccgtgctc aatgtcgcgc tgcaggtggt gaacgactgc aacgcgatgc
     9541 tctcgccctt cctgccccac tccgcccaga aggtgtacga gcagctgggc ggggccggcc
     9601 ggtttgcgcc gatgccggag atccaggagg tcgaggacct cgacggcggc gccggctatc
     9661 cggtcctcgc cggcgactac cagaccggcg cttcgtgggc tccccagtcg ctgccgcccg
     9721 gtcgcgagtt ggcgcccccg aagccggtct tcaagaagct ggatgcgggc atcgtcgacg
     9781 aggagctggc ccggctggcc ggcgatcagt aacccgccgc ccagccggcg ccggccttgc
     9841 gggaccggcg ccggggaggc cggtcagtct tcgcagatgc gggtggggtt acccggtatt
     9901 gggatgctgt agacactcca cgggtagctc gggccggtat gcgggcccgc tggttcttcc
     9961 ggctcggccg gaagttgttg gagcgcgagc acgttgttca tcagttcacc tccctagttg
    10021 ttgtcgaaat gaacagctgg ccggtcggac cggccaggat ccggtggagc gccagcagta
    10081 cgccggctgc gcccgtacct aggtcgcagc tgaatcgcag tcgaccggag ccgagtaccc
    10141 ggctacgtcc ggcggggccg ggggcggcat aggcgaccag tccggcggcc agccgctgcg
    10201 cggtcgcccc cgccgaaggg tcgctggcgc ccgcgaggtc ggcgtgttcg gcgtgggcga
    10261 agacgagacc ggccagtcca aggtagagtc cggactcgac ggtaaccggc tggtgtgcgc
    10321 cggccagcac agccgcgctg gcggtggcga gtcgctcgtc ggtgtcgtcg gcgtggcggt
    10381 agcgggtcag caccagggcc accccggccg agccgatccc aaggtagggc atcatgcgtg
    10441 gggtggcgtc gtcgtcgggg aacatgagat ggccgcggat ctcgaccccg cgaccgagtt
    10501 cgtccacgag tagctggcgt ccgacttcga ggtagtgctt cgcatcggtg gcgcgccaaa
    10561 gctggtgcag gaagagcgcc atgcccgaac gtccgttgag gagtccggtg gggttgtccg
    10621 gcccgaggag ttcagccgct tccgccatga ccagctggtc gcccaattcg acggcctgag
    10681 ccagcagcgc ggcctcgccg gttcgggcat gcagcgtcaa cagtgcggtt ccgaccccgg
    10741 cgctgccgcc gctccacgag ccggcggtac gggtgaggtg gtgcgtgcgg gcggcctcca
    10801 ctagggtgag tgcctcgtcg agctggccat actcgcccag cacggcggcg atcccggcga
    10861 ggccgtagtg gagccccggt gggaactctg cccgccgggc aagcgcttcg gaccggaacc
    10921 gggcgacgct acgcgggtcg gcgggtagcc cggcgtggtg cagagcgtgg aggacgccgg
    10981 cggccccgtg cgcgaggttc caggtgttgg tggtgtaccc ctcggggacg gtcggccaga
    11041 tccggtccgg gtcgtcgggc gctgcggtgg cgaccagttc gcgtccgatc gcgtcccgca
    11101 gtcgacgtag gtggcgaatc gggtcggcgg cgagctctac cggggcgggt gtgaccgggg
    11161 cgccgccggc gttgccaccg ggggtgggaa ggtgccgggt ggcgagctgc cagagcgacg
    11221 ggggcaccgg gtgtcgccgg ttcaggtggg ctgccaggtg ggccacggcg gccgggttgc
    11281 ggaccagctg ctggtgtact ggtgccagca tggtcagcgc aaccgcgctc agaccgtagt
    11341 cgtcggcccc ggttcctgcc ctggcgtggg ggtcgggcgg caggtagccg ggtgcgccga
    11401 ggtcgatcgg cggctggtcc agtcggttgc acgactcgaa gtcgatcagg cgtacctggc
    11461 cgtcgtcggt gatcaggacg ttgcgcgggt tgacgtcgcc gaaccggtag ccgagctcgt
    11521 gcagccgctg tagcgcccgg ttcagctggg cgaggtagtc gagacaggcg tggaagtacg
    11581 actcgaactc ggccgggctg ccctcctgca ggtacgggtt gcggcgggcg gcgtagccga
    11641 acagtgagct acccggcacc agttcggtga cgagaaagtc atgctcccac tcccggaaca
    11701 gttcgatcgg ctccggagcc aggccggggg cgcgggtgtg gaggtcgccg agcacccggt
    11761 gctcgcggtg gagccgctgc gacgcggtgc tgccgtccca gtggaagccg gtgtgcgccc
    11821 gggcctcttt caggaagacg ggccggccgc tggcggctac ggctcggtaa gccccgccgg
    11881 cgttgctctg tgccagcgcg gcggtcgccc ggtagccacc gatcatcacg ccgccgtcgg
    11941 tctgcgccgg tgccggggct ttggcgagga acgggtcggt gactccctcg ggcagcatga
    12001 actggtggct gcggaggtcc tccacccatt ggccggagcc gttggtgagc agtggcaccg
    12061 cgcgaccatc gagcgtgact cgggtccggg cctggaaggc tccgtaccgg tagtgcactg
    12121 tgcgggagtc gccgaaccgt cggtcgctga ggatatacgg gcccggttcg tcgaccagcg
    12181 ccccggcgag ctctgtcaac agctgccggg ccgcggactc agttgctggg tagagggtgc
    12241 agaactttcc ggcctgggac cggacgccgt gcttgtgtcc catgagtaga aacgcgaact
    12301 cgctggccag gtgcttgaac gagacggtgg cggtagcaca ggcggcggtc acgctgtcga
    12361 ggactcggga ggcgccgggg agcgtggccg agacgtggat cttccatccc tgcgccggca
    12421 gcggcggacc ggagggcggc tcccagctca gccagacgtc gtgccggctg ctccgccagc
    12481 caaccggcgg gctgctgggg cgcagcggtc ggctgttgtc ctggtgtcgg tggcggggtt
    12541 cgtagtagtc aggatcggcc aaggtatatg agaccgtggt caaatccacg atgagcgccg
    12601 tggtcgggaa tgcacgaggg acctcccagg atggaaaggc gcccccgtcc cacctattcg
    12661 gaactctccg gagtcatcct attccgctgc gcccacctta ggcaaggtgt cacctccgag
    12721 cgccgccccg tgtccgggtt gaccgatttc gggccatgaa ctagatttag atccctagat
    12781 gccacgtcgg tggtgtcgcg ggagcgtccg gggatccgct gacgtcgggg cgcgcaggtg
    12841 cgccagcggg aggccgcagc tcacacccgc ctactctcct gagttgggag ttccacatgc
    12901 gaccccatat cgccggctgg cgtacgccac tggctctcct cctgtcgttg gcgctcaccg
    12961 ccacgctgat cggtccggcg gtgggggcgc cgggggccgc cgacgccgcg ctgaccgtcg
    13021 gctcggtggc ggcggcgcag ctgtggatct cctatgacga cggtgggagc tggtcgccac
    13081 agtcggtgca gccgtcgggc gaaggcagct tccacaccaa cctgcctact ccgccgttgg
    13141 atcactctgg gttcgggtcg atccgggtgg tcgcgagtga cgtcgagggg aaccagatcg
    13201 accaggaggt gatccgcgcc tggcgggttc cggcgccgtg acctggataa accccgacta
    13261 tgcggattct gaatcgccgg tggttagcgt cgtcctcgtc aatgcgagac gagggggtgt
    13321 caccatgtcg ttcttgagcg tgctgccggg ggtggtcggt gcggccggga gccgtaccgc
    13381 catgaccgct ggggactggt ctggttgggc gcagcacagc gaaaccatgc tgcgcaacgc
    13441 gggtggcggc tgccgatcgg gcaaactcag ctccgccttc gacagctacc tggcccagct
    13501 acggccgtgc ctgcagaacc aggcggtacg ggcgagcgcg ctgggtggca acgcggctag
    13561 tgcggcgagc gccgtggacc aggcggacgg cgacagctca ggggtgctcg gcggccaggt
    13621 cgggaacctg gtgtcgcagg cctcggtgct ggcgcggcag atcaacttcg gctgaccgcc
    13681 gccgagggaa gcggaggacc tgtcgtcatg gaaccctttg agaagcacca ggcggacgtc
    13741 ggcgagctgc acgcggccag ctccggcctg ctcgccgacg cctcgcaggc cggcgacaac
    13801 gtgtcgctga ccacccacgc atatcagccg gtgatcgacg actggcaggg gctcggtgcg
    13861 ggcgaggcgc agggggcgcc gcagccgctg cgggccggcg ccgaccaggc cagcacgtcc
    13921 ctggcgtggg cggcggtggt gaccgagttc tgggccggca aggtggagac cttcaactct
    13981 gaagtggaca aaattgtcga acggtacgag agccaggggc ctcgctacgg ggtgaccggt
    14041 gacgacccgg atgacgacga gatcgagcag gcccgcctgg atgcgctcgc caaggcgcgt
    14101 gagcagtggt gggaggcgta caacacgcac atcctcgacg gcgaggacca ggccgccgcc
    14161 atgctcgccg acggccccac cgaggcgaac ctgtcggtgg cgaaacggtt ctttgatgga
    14221 atggactggt tcacccggaa catcggtccg gcgatgccgt ggatcatgtc ggagctcttc
    14281 ttcggcggca gatgggcgca tcacaggtgg tggacgcggc attacctgat ctgggcacaa
    14341 cggtacgtgg acggacgctg ggctggcggt gttccggatg ccaaaggggc ggcgcggctg
    14401 gtaacgaccg ccctccgaga gagcggccat ggtcagcgga tgcggcagat ggcgacctgg
    14461 gcctcccgct tgagcttggt caccgccggc ggggccgccg ccggattcca gtggtacgac
    14521 gatcggaaca ccggatacac caccgaatac cgggtagcgc gcgccggtat cgccggtggg
    14581 atgacggctg gcttcgccgc cgcgggtggg ctgctcggcg ccgcggcggg cgccggcctt
    14641 ggcccgaaag gggtggtagt tggctcggtg gtcgggagca cgctcggcgg catcgcgggt
    14701 ggttgggcgt ccgaccgtgc gatcgacagc ctcgattatg tcatcgacca cgcggccggt
    14761 tcggcgcccg gctcctcagg cggtgtcagg gacggtgccg ccgcatacgt cggtgccgcc
    14821 gccggcaacc ttaccgagct gagcaacctt ggccggtggg cggttcccgg cagcagcggg
    14881 acgcccgagg cggacccgac gcaggtacgc gacgacgtga cgaactggtt ggcggggcgc
    14941 tagatgagag gggacgcaac tgtgcatgca gcgaaggccg aggagatggt ccaatacaaa
    15001 cacccgcggg cgggtttctc ggtgcccgtc ccccgcgaat gggagcgcgc agtagatact
    15061 gcggaagtgc cgctgatcgt ggcggcacca cctgatccgc cctggcggtt ccgggcgaac
    15121 ctgattgtca ccgtcgacca gctcgggcca gaggtgacgg ttgccgcgcg gcacgcggcg
    15181 aacatcgaag ggctgcatcg ggcgcttacg cggtttcgtc tgcttgatca ggaggagagt
    15241 cggctgcggg ggtgcccact gctccggacc ctcggtcatc atgcggcgga ggcaggagcg
    15301 gtgacgttcg aacaatggat ctacattggt gaggagcact gcttcgcgct gaccgcctcg
    15361 gtaggcacat tggaatatcc cgcctatcgc gagatattcg ccgcgatggt ttacgagttc
    15421 cggcttccgc aggaggtttc gtgacagtct catttgaccc ggtcaatggg cggctacggc
    15481 tagacgatgt aagcttcgca gttcttaggg acctggttcg tcaagactcc accgagcagc
    15541 tggacgggca tcaccttgcc gagctacgtg acagcggtgt ggtgcgcggc tgcataccgc
    15601 atccttctct ggcgtacggg cttgacgcgg tggccgtgcc cgtgtgccgg ctcacgttgc
    15661 gagtcgacac cccggagacg gatgtactgc gcacccggca cgtggctggc tggttgggcc
    15721 gggacgcgat ggcggtgctt cgggacgacg acgacggtct ccgggagttt cggacacaac
    15781 cagtgacgct cttgccagag ctggtcgcca ccgagaccga gttcgggccg cgaccgcgac
    15841 cgccggagct gttcttcgcc gtgccggcgg atgtgtggga ggagctggtc accacggtca
    15901 acggcagggc tgagcgggag caggcgatgc tgcggtttgt cgatgccgcg gccgaggccg
    15961 gcccggcggc ggccgatgcg gcccggcggc tggtgacgag cctaaggcgg cggtgggagg
    16021 tggcggtgcg ctggcggccg gcgcccggcg cggtaggtga acggtcgctg caggtagtcg
    16081 acgcgcaggt cggcctgtgg cgggtgacaa cgggccccgg tgcggtcacc ctttcggcga
    16141 ccaccccgac cgtggtctgg caggagatca tcggtctgct cccgcaggac gacgagcttg
    16201 cggcgcccga atcggagccc gcccgggctg gctccgctgc tgcgggcggc ggcctggaat
    16261 catggcaggg tgagtggagc ggacgcggat gaacggcggc agcgggcggc ggggcggggc
    16321 gagcacgagg cgccgccggc cccggagccg ttgccgttgc cggtggtgga cagccacacc
    16381 cacctggacc tggtgagcga cgccggtggc ggcgatccgg cggcgcagct cgccgccgcc
    16441 gccgcggtgg gggtggaccg ggtggtccag gtcggcgtcg acttgccgtc gtcccggtgg
    16501 gccagccagc tcgccgccga gcacccgcag gtgctcgcca cggtcggggt gcacccgaac
    16561 gaagcgcccc ggctcggcga cgggctcgac gaggcgctgc gggaggtgga gcggctggcc
    16621 gcggcaccgc gggtgcgggg ggtcggggag accggcctgg acacgttccg gaccggcccg
    16681 gagggggctg cggcgcagga ggccagcttc cggggccata tcgcgatcgc gaagcggttc
    16741 ggcaaagcct tgatcattca cgatcgggag gcgcacgccg aggtgctgcg ggtgctcgac
    16801 gacgagggcg cccccgaccg ggtggtgatg cactgcttct cgggcgacgc tgagttcgcc
    16861 gacgagtgtc tccggcgcgg gttcgtgctc agcttcgccg gcaccgtgac cttccgtaac
    16921 gccaggtcgc tgcgggaggc ggcgcgtcgt tgcccgccgg accggttgct ggtggagacc
    16981 gatgcgccgt acctcactcc gcacccgtac cgagggcgcc ggaacgggcc gtatctgatc
    17041 ccggtgaccg tccgcgggtt ggccgaggcg cggggagtgg agctggcccc gttgtgtagg
    17101 gcgatcagcg acaccgggga gtgggtcttc ggtggctggg gcggggcgtg accgggttgt
    17161 tgggcccggc gcagctgcgg gagctcgcgg accggctggg ggtgcggccg accaagcagc
    17221 gggggcagaa cttcgtggtc gacgccaaca ccatccggcg gatcgtcacc gccgccgggt
    17281 tggatccggc cgatgtggta ctggaggtcg gtccgggttt gggttcgttg acgctggggt
    17341 tgcttccggc ctgtcgccac gtccacacgg tggaggtcga cccggtgctg gccgccgccc
    17401 tgccggagac ggtgcacggc tgggccccgg agtacgctga ccggttcacc ggccacctgg
    17461 cggacgcgtt gacgctgtcc gagctgccgg aaccggcccc gaccgcgctg gtggcgaacc
    17521 tgccgtacaa cgtggcggtg ccggtggtgc tgcatctgct ggcggtggtg ccgacactgc
    17581 ggcacggcct ggtgatggtg cagcaggagg tggcggaccg gttgaccgcc ggtccgggtt
    17641 cccgggtgta tggggtgccg tcggcgaagc tcgcctggta tgcgcaggcg cggccggcgg
    17701 gccgggtgcc ccggacagtc ttctggccgg cgccgaacgt cgactccggg ctggtggcct
    17761 ttgcccggcg ggagcccccg gccggtccgg cccggacggc ggtcttcgcg gtggtcgacg
    17821 ctgcgttcgg gcagcggcgc aagatgctgc gaacggcgct ggcgggctgg gccggcggcg
    17881 ccgcgcgggc ggaggcgctg ctcgacatcg cgggggtgcc tgcgcaggcg cgggccgagt
    17941 cgctcaccat agagcagttc gcggcgatcg ccgccgcggc cactaccgcc gccgagggga
    18001 cgacccagtg accaggccgt tgtgggcaga cgacgagtat gaccagccga agccggccgg
    18061 caccggcgcg gtgcgggtcc gggttcccgc gaaggtgaac ctgcacctcg gggtgggcga
    18121 ggttcggccc gacaactatc acgaactcca gaccgtctac catgcgatct cgctcttcga
    18181 cgaggtgacg gcccggccgg gggacacgtt ggccctcact atggccggtg agggcgccgg
    18241 tgagctggcc ctggacgatt cgaacctggt gctgcgggcg gcccgggcgc tggcggagca
    18301 cgccgacgtg ccggcccacg cgcggctgca cctgcgcaaa cagatcccgc tggcgggtgg
    18361 cttggccggc ggcagcgccg acgccgcggc caccctggtg gcctgcgacg cgctgtggga
    18421 cctcgggttg tcgcgggagg agctggccgg gttggcggcc gggctcggcg ccgacgtgcc
    18481 gttcctgatc tacggcggca cggcgctcgg gatcggccgg ggtgagcagg tgagtccggt
    18541 gctggcccgg ccgggggtgt ggcactgggt ggtggggttc cacgatggtg gcctggccac
    18601 ccccgaggtt taccaggagc tggaccggtt gcgggcggcg gacgcggcgc cggcgccatt
    18661 gccggagccg gcggggctgt tggcggcgct gcggcagcgg gacccggaag tgctcggtgc
    18721 ggcgctcggc aacgacctgg cggcggcggc ccggtcgctg cggccggagc tgtcggcggt
    18781 gctcgccgcg ggggaggcgg ccggggcgtt ggccgggttg atctctggct cgggcccgac
    18841 ctgtgtcttc ctcgcccggc acgccgaaca cgccgccgag gtggcggcgg cgttgaccgg
    18901 tgcggaggta tgccgggcgg tgcggacctg tcacgggccg gtgccgggcg cccgggtgca
    18961 gcactgagtg gccggcgctc gcgcgcgccg gctcaggtcg tacctcaggg ctcggcctga
    19021 tccgggaccg gggggtcggg taacagccgg ttgcggaccg tgtcgaccgc caactcggtc
    19081 cgggaggtga caccgagttt ccgcatcgcg gagctgagct gcccggcgac cgtcttcggg
    19141 gatcgggaca gcgcggcggc gacctcccgg ttggtggcgc cggtggcgac cagccgcacc
    19201 acatctagct cccgcggcga aagccggtcg ccgtagccgc gccgaccgcg gcgccactcc
    19261 cggcgggcgt ccaccccgtg ggcccgcagc agctcaccga cccgctcggc gtcgccccgg
    19321 gcgcccagct cggacagcgc ctggaaggtg gtgccgagcc gggtcagcgc ggcagcctgg
    19381 cggtcgccgg ccagctcggc gacggcctgc tgttcgcgcg ccaacagcgc ctcgtacggg
    19441 cgggggagtt cttcccaggc acgcgccgcg accgcgaacc ggccggccgc cgccggagcc
    19501 gggccggtgg ccgcggccag cagcgcccgg caggtcgcca gcgccgcccg cccggccggc
    19561 gccgggcagc ggcgcatccc ccgctggtac gcgttgacga gctcctcggc ctcggatagt
    19621 cgcccggcgg cgagcagtgc ggcgacgcgt accggggcga gttcggtagc ccagatccag
    19681 atgcccttgc cggccaccgt cgccatcgga cgctcggtat acgccaacgc atcgtcgacc
    19741 tggccccgcg acaacgcgag ccggccgagc gcggcggccg gttcgagacc atcgtcgacc
    19801 gtgccgatcc gggcgacctc ggcgagcgct tggcgtagcg ccgcctcggc tcgccggtgg
    19861 ctgccttggg cgaggtgcca caggccgact cggaccgcgc cgagcagcgc tagcggctcg
    19921 tcggagctgg ggtcggcggc ggtggtcacg tgctcggtga gccctgccca ctggccggtg
    19981 taccactcca actgtgcctg ggagatccgg atcagcggcc cgagccgcag gtagcggtcg
    20041 gcgtcggcga gttcggcggc ctggttgagg agctgttcgg cgtgccggta gcgcccccac
    20101 aggatggcgg cggcgccgat gttgaggtag ccgcgggcga cctgccgccg ctcctcggcg
    20161 gtgcggccgg ccgcccccag cacggtggcg ggtagttcgt cggcgaccgc ccagccggct
    20221 gggtcgccca gctgcagcag cccggcggcg cggtcgacgg tcaacgcgag ccgctcggcg
    20281 gcgggcagcc gggccaggtc cacgcctgct gcccgctgca accaccggcg gtggacggtg
    20341 gcgggttcgt cgccgacgaa gggcaatccg aggaagcgca tcgcgcgggc ggcctcgacc
    20401 gggtggtgat cgagctggct gaccgcccgc ccgatctcgg cccgggccgg gccgaactcg
    20461 cctagctggg ccagcagccg gccgaagccg ctgcgcagtt cggcgtcctc ggtcggggag
    20521 agcgtggtgt ccgccagcag ccggcgcagc gtctcgaccg cccgctgatg cagctcgtcc
    20581 acggcttcgc ggcggtagct ggcggcgagc gcgaggcggc ggccgagcct gacctggtcg
    20641 tcgatgctgc ggttaggtgc ggcgagggcg tcgaggagca gcgctaccgc ggcgtcgtag
    20701 tcgcccgatt cgccggcctg gtcggcggct agttcggcgt agcgcatcca gcgtgcgggc
    20761 tgccgggctt gtttgaagtg tcgggccagg gccgcgggcg gggcggtgcc cgcttcggcg
    20821 agcgcggtac cggcggccag gtgcagggcg cgccgccggg ccgccggtaa tgattcgtag
    20881 accgcctggc ccatcagcac gtgccggaag ctgctgcgtt ggtcgccctc ttcccggagc
    20941 aggccgccgg ctatggcctc accgagaccg cgccggacct ggtcgaacca tgcgtcgggg
    21001 tctgattggg cgtcggggtc cggctgggtg tcggccgccg cgacgcgggc gatcaccgcc
    21061 tcggtggccg gggccgctag cacggcggct gcggccagca cctgctgggc cgaggccgac
    21121 aggcggggga tcctggccag caccgtgtcc cggatggtcg gcgggacggt gagctcgggc
    21181 agccgttgcc gcacccattc gccgccgcgg cgcaccaggt cgccccggtc gcgcagcagc
    21241 cgcaccgact cctccaccgc cagcggtacg ccctcggtgt gctggtggag gaagtccgcg
    21301 agatcctccg agatcggctc gccgggcagc atcgacgacg cgagccgggc ggtgccggcg
    21361 gtgtccagcg cgggcacggg tatccgcagc tgccggttgc cggccgaggg tcgggacgag
    21421 agccgcagca gcagcgagtc gggcggaacg tcggcgggcc ggtagctgac gatcaggctg
    21481 gcggcctggc cgggagggcc gggtgttccg ccggtgccgg tgagccggtg ggcggtggcg
    21541 gcccgaccgg cgaggaacag caggaactcg agggtggcga cgtcagccca gtgcacgtcc
    21601 tctaccacga tcgcttggaa gctgagctgc ccgagcagct ccgccagggc ccggaagagc
    21661 cggtggcggg tcgctttcag gtcgggcagc ggctcgggcg gcggcggcag ccggtcggcc
    21721 caccggggga agagcggccg cagcgcaccg gcgagcgcgc tgagcggcag gtcggggacc
    21781 tcggcccggt gccgctggag ggcgtcgacc agcggcgcca gcagcagcgg ctccgggtgg
    21841 ggtgggcagg cacaccacag cagccgccgg tcgccgctgg cggcggcgaa ctcgcgcagc
    21901 aaccggctct tgccgatccc ggcttcgccc tcaacgagga ccagcgcggg ttcggtcagg
    21961 gtccggagca gcgcggcgac ctccgcttcc cgccccacca gcgcgggtgc ggcgaagccg
    22021 ggggtggtcg gttctggcgt tccggtggcg agtccgggca acgtcgccct cctcacgctg
    22081 tctttcagcg gtgatcgctg ggtggaatcc tacgggtacg ggggtggcgc agcgcagtga
    22141 tcggggtgcg ggacaattcg gtagtgcgca ctgaccggcg ccgcccccga gcgaccttgg
    22201 cccctggaga cccctgatgt cacacattcc cgtcaatcat ccgttgcgcc ccttgtaccg
    22261 cggtgtcgcc atcgtgatcg ctggctggct ggtgaccttc ggtgtggtcg gcctcgtcca
    22321 gacgcagggg gaggactggc tgggtcgggg cgattggagt gcgctcggca tccccacgaa
    22381 tggcggattt tcggtggtct gcctcgtggc tggtgtagtg atcctgctca cctcagtgat
    22441 cgggcgcaac ctggaccgca tggccaactt ctggctgggc ggcggcttcc tggtgatcgg
    22501 gaccgcgatg atggcgctgg tcgccaccga ggggaacgtc ttcaacttct ccagcgtcac
    22561 caccagcatg gcgtacctgg tgggggtcg
//
