Select genomic region:
Overview
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### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP070499.1 (Natronosporangium hydrolyticum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | hydrogen-cyanide | 78,391 | 92,391 |  |
Region 2 | T3PKS | 269,808 | 310,875 | Medium | loseolamycin A1/loseolamycin A2 | PKS
Region 3 | phosphonate | 479,378 | 509,386 | Low | phosphonoglycans | saccharide
Region 4 | resorcinol | 699,351 | 741,222 |  |
Region 5 | lanthipeptide-class-iii | 758,896 | 781,484 |
Region 6 | T2PKS | 1,324,413 | 1,396,892 | High | SEK90/pentangumycin | PKS
Region 7 | t3nrps-iterative,T1PKS,oligosaccharide | 1,453,667 | 1,584,173 | High | vicenistatin | PKS+NRPS:Type I+other:other
Region 8 | terpene-precursor | 1,812,217 | 1,833,293 |
Region 9 | NRPS-like,NRPS,T1PKS,T2PKS | 1,866,520 | 1,980,978 | Low | formicamycin A/formicamycin B/formicamycin C/formicamycin D/formicamycin E/formicamycin F/formicamycin G/formicamycin H/formicamycin I/formicamycin J/formicamycin K/formicamycin L/formicamycin M/fasamycin C/fasamycin D/fasamycin E | PKS:Type II aromatic
Region 10 | lanthipeptide-class-iv | 2,324,537 | 2,347,260 |  |
Region 11 | ectoine | 2,544,209 | 2,554,583 |  |
Region 12 | RiPP-like | 2,565,925 | 2,578,192 |
Region 13 | RiPP-like | 2,844,977 | 2,856,212 |
Region 14 | azole-containing-RiPP | 3,030,572 | 3,053,977 |  |
Region 15 | NI-siderophore | 3,169,163 | 3,198,932 | Low | FW0622 | other:other
Region 16 | lanthipeptide-class-i | 3,223,045 | 3,248,160 |
Region 17 | lanthipeptide-class-ii | 3,649,704 | 3,672,745 |
Region 18 | lanthipeptide-class-ii | 3,907,047 | 3,930,031 |
Region 19 | terpene | 4,428,672 | 4,451,691 |  |
Region 20 | NRPS,T1PKS | 4,652,958 | 4,734,842 | Medium | holomycin | NRPS:Type I
Region 21 | lanthipeptide-class-i | 4,871,698 | 4,896,879 |

NZ_CP070499.1 - Region 1 - hydrogen-cyanide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 78,391 - 92,391 nt. (total: 14,001 nt) Show pHMM detection rules used
hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase reductase
JQS43_RS00410: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

JQS43_RS00425: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

Isomerases: mutase
JQS43_RS00450: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hydrogen-cyanide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002345.2 |  | 0.63 | other (other) | hydrogen cyanide | Pseudomonas fluorescens
BGC0000906.3 |  | 0.33 | other (other) | heme D1 | Heliophilum fasciatum
BGC0000905.5 |  | 0.33 | other (other) | heme D1 | Heliobacillus mobilis
BGC0002285.2 |  | 0.30 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0002448.2 |  | 0.27 | NRPS | Q6402A | Streptomyces violaceusniger
BGC0000696.5 |  | 0.25 | saccharide | gentamicin | Micromonospora echinospora
BGC0001514.5 |  | 0.23 | other (other) | aristeromycin | Streptomyces citricolor

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002345.2 |  | 0.63 | other (other) | hydrogen cyanide | Pseudomonas fluorescens
BGC0000906.3 |  | 0.33 | other (other) | heme D1 | Heliophilum fasciatum
BGC0000905.5 |  | 0.33 | other (other) | heme D1 | Heliobacillus mobilis
BGC0002285.2 |  | 0.30 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0002448.2 |  | 0.27 | NRPS | Q6402A | Streptomyces violaceusniger
BGC0000696.5 |  | 0.25 | saccharide | gentamicin | Micromonospora echinospora
BGC0001514.5 |  | 0.23 | other (other) | aristeromycin | Streptomyces citricolor

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 25.20 out of 29.72
Confidence: medium
Additional weak hits (1):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.96 out of 26.33
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
NtrC | Nitrogen regulatory protein C

NZ_CP070499.1 - Region 2 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 269,808 - 310,875 nt. (total: 41,068 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
JQS43_RS01395: Hydroxylation

MITE
  MITE0000081Hydroxylation (identity: 74.80%)
smcogs
  SMCOG1006: acyl-CoA dehydrogenase

JQS43_RS01445: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: methyltransferase
JQS43_RS01390: Methylation

MITE
  MITE0000082Methylation (identity: 60.90%)
smcogs
  SMCOG1089: methyltransferase

Hydrolases: deformylase
JQS43_RS01355: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

Ligases: synthase
JQS43_RS01400: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001077.4 |  | 0.68 | PKS | 6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone | Actinoplanes missouriensis 431
BGC0002362.3 |  | 0.65 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0002332.2 |  | 0.45 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001224.5 |  | 0.41 | other (other) | reductasporine | uncultured bacterium
BGC0000255.5 |  | 0.40 | PKS | pederin | Uncultured bacterium
BGC0001521.3 |  | 0.38 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0001591.4 |  | 0.38 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000700.5 |  | 0.36 | saccharide | istamycin | Streptomyces tenjimariensis
BGC0001387.5 |  | 0.36 | other (other) | nucleocidin | Streptomyces calvus
BGC0000716.5 |  | 0.35 | saccharide | spectinomycin | Streptomyces netropsis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001077.4 |  | 0.68 | PKS | 6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone | Actinoplanes missouriensis 431
BGC0002362.3 |  | 0.65 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0002332.2 |  | 0.45 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001224.5 |  | 0.41 | other (other) | reductasporine | uncultured bacterium
BGC0000255.5 |  | 0.40 | PKS | pederin | Uncultured bacterium
BGC0001521.3 |  | 0.38 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0001591.4 |  | 0.38 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000700.5 |  | 0.36 | saccharide | istamycin | Streptomyces tenjimariensis
BGC0001387.5 |  | 0.36 | other (other) | nucleocidin | Streptomyces calvus
BGC0000716.5 |  | 0.35 | saccharide | spectinomycin | Streptomyces netropsis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.39 out of 25.31
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.52 out of 29.72
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.58 out of 23.05
Confidence: strong
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.28 out of 19.52
Confidence: medium
Additional weak hits (12):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.75 out of 23.43
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.68 out of 28.14
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.27 out of 29.51
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.57 out of 20.97
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.83 out of 32.74
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.30 out of 21.55
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.83 out of 24.78
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.78 out of 29.65
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.32 out of 29.65
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.35 out of 26.06
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
AfsR | Pleiotropic regulatory for antibiotic production
CatR | H2O2-responsive repressor
NtrC | Nitrogen regulatory protein C

NZ_CP070499.1 - Region 3 - phosphonate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 479,378 - 509,386 nt. (total: 30,009 nt) Show pHMM detection rules used
phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidase
JQS43_RS02325: dehydrogenase

smcogs
  SMCOG1181: dehydrogenase

JQS43_RS02345: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

JQS43_RS02400: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phosphonate | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000897.5 |  | 0.48 | other (other) | dehydrophos | Streptomyces luridus
BGC0000938.5 |  | 0.48 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0001739.3 |  | 0.45 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0002670.2 |  | 0.44 | other (other) | fosfonochlorin | Fusarium oxysporum f. sp. lycopersici 4287
BGC0000904.5 |  | 0.44 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0000937.5 |  | 0.40 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0000926.5 |  | 0.40 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000806.5 |  | 0.40 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0000807.3 |  | 0.38 | saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0000936.5 |  | 0.37 | other (other) | pyocyanine | Pseudomonas aeruginosa PAO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000897.5 |  | 0.48 | other (other) | dehydrophos | Streptomyces luridus
BGC0000938.5 |  | 0.48 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0001739.3 |  | 0.45 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0002670.2 |  | 0.44 | other (other) | fosfonochlorin | Fusarium oxysporum f. sp. lycopersici 4287
BGC0000904.5 |  | 0.44 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0000937.5 |  | 0.40 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0000926.5 |  | 0.40 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000806.5 |  | 0.40 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0000807.3 |  | 0.38 | saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0000936.5 |  | 0.37 | other (other) | pyocyanine | Pseudomonas aeruginosa PAO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.39 out of 29.72
Confidence: medium
Additional weak hits (6):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.08 out of 32.74
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.41 out of 25.75
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.21 out of 27.04
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.91 out of 20.01
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.21 out of 31.73
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.92 out of 28.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
NtrC | Nitrogen regulatory protein C

NZ_CP070499.1 - Region 4 - resorcinol
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 699,351 - 741,222 nt. (total: 41,872 nt) Show pHMM detection rules used
resorcinol: DarB

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
JQS43_RS03320: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: methyltransferase
JQS43_RS03175: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | resorcinol | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.5 |  | 0.46 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000503.5 |  | 0.44 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0001526.4 |  | 0.44 | other (other) | bartoloside E, bartoloside F, bartoloside G, bartoloside H, bartoloside I, bartoloside J, bartoloside K | Synechocystis salina LEGE 06099
BGC0001525.3 |  | 0.43 | other (other) | bartoloside B, bartoloside C, bartoloside D | Synechocystis salina LEGE 06155
BGC0001374.5 |  | 0.42 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0000874.5 |  | 0.42 | other (other) | blasticidin S | Streptomyces griseochromogenes
BGC0001210.5 |  | 0.41 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002733.3 |  | 0.41 | other (other) | sinapigladioside | Burkholderia gladioli
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.5 |  | 0.46 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000503.5 |  | 0.44 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0001526.4 |  | 0.44 | other (other) | bartoloside E, bartoloside F, bartoloside G, bartoloside H, bartoloside I, bartoloside J, bartoloside K | Synechocystis salina LEGE 06099
BGC0001525.3 |  | 0.43 | other (other) | bartoloside B, bartoloside C, bartoloside D | Synechocystis salina LEGE 06155
BGC0001374.5 |  | 0.42 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0000874.5 |  | 0.42 | other (other) | blasticidin S | Streptomyces griseochromogenes
BGC0001210.5 |  | 0.41 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002733.3 |  | 0.41 | other (other) | sinapigladioside | Burkholderia gladioli
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (10):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.89 out of 30.25
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.17 out of 39.62
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.89 out of 39.62
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.20 out of 31.73
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.38 out of 32.74
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.93 out of 28.19
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.18 out of 33.14
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.71 out of 27.18
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.33 out of 29.65
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.45 out of 26.85
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP070499.1 - Region 5 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 758,896 - 781,484 nt. (total: 22,589 nt) Show pHMM detection rules used
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
JQS43_RS03490: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

JQS43_RS03495: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002700.2 |  | 0.48 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0001226.4 |  | 0.46 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000551.5 |  | 0.46 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000563.4 |  | 0.46 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0002111.3 |  | 0.45 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002701.2 |  | 0.40 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0000546.3 |  | 0.36 | ribosomal | SAL-2242 | Streptomyces albidoflavus
BGC0000625.5 |  | 0.29 | ribosomal | thioviridamide | Streptomyces olivoviridis
BGC0000874.5 |  | 0.29 | other (other) | blasticidin S | Streptomyces griseochromogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002700.2 |  | 0.48 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0001226.4 |  | 0.46 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000551.5 |  | 0.46 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000563.4 |  | 0.46 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0002111.3 |  | 0.45 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002701.2 |  | 0.40 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0000546.3 |  | 0.36 | ribosomal | SAL-2242 | Streptomyces albidoflavus
BGC0000625.5 |  | 0.29 | ribosomal | thioviridamide | Streptomyces olivoviridis
BGC0000874.5 |  | 0.29 | other (other) | blasticidin S | Streptomyces griseochromogenes

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for JQS43_RS03505

allorf_0768759_0768896
Leader:
MNNVLALQQLPAEPEEPAGPHT
Core:
G P S Y P W S V Y S I P I P G N P T R I C E D
Core with dehydrations:
G P Dha Y P W Dha V Y Dha I P I P G N P Dhb R I Cys E D

#### antiSMASH-DB 4.0 matches for allorf_0768759_0768896

100.0%
NZ_CP070499.1:
Lanthipeptides: allorf_0768759_0768896_lanthipeptide
1
G P S Y P W S V Y S I P I P G N P T R I C E D
23
G P S Y P W S V Y S I P I P G N P T R I C E D
1
G P S Y P W S V Y S I P I P G N P T R I C E D
23
22.2%
NZ_CP029560.1 and 1 other:
NZ_JADOZM010000015.1 Lanthipeptides: I4U92_RS06525_lanthipeptide
Lanthipeptides: DLJ51_RS10415_lanthipeptide
1
G P S Y P W S V Y S I P I P G
15
G + W S +S I G
13
G G C H N W S T F S I G A C G
27
20.7%
NZ_JACHOW010000006.1 and 1 other:
NZ_JACHOW010000006.1 Lanthipeptides: FHS01_RS11995_lanthipeptide
Lanthipeptides: FHS01_RS11995_lanthipeptide
13
I P G N P T R I C E
22
I P T R+C E
16
I D A C P T R L C E
25
with 1 more sequence matches
11.4%
NZ_LIPG01000002.1 and 1 other:
NZ_LIPG01000002.1 Lanthipeptides: AMK10_RS08930_lanthipeptide
Lanthipeptides: AMK10_RS08930_lanthipeptide
1
G P S Y P W S V Y S I P I
13
G P P W+ +++P+
32
G P D L P W T T F T V P M
44

#### MIBiG 4.0 matches for allorf_0768759_0768896

17.4%
BGC0000580.3 (EGD17354.1):
Lasso peptide: xanthomonin II or xanthomonin I
1
G P S Y P W S V Y S I P I P G
15
G P + +P G
2
G P L A G E E I G G F N V P G
16

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (1):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.64 out of 21.55
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_0768759_0768896 - Class III
  Cleavage pHMM score: -2.90
  RODEO score: 0
  Monoisotopic mass: 2475.2 Da
  Molecular weight: 2476.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2494.8 Da N = 1
    2512.8 Da N = 2
    2530.8 Da N = 3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP070499.1 - Region 6 - T2PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,324,413 - 1,396,892 nt. (total: 72,480 nt) Show pHMM detection rules used
T2PKS: (t2ks and t2clf)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
JQS43_RS06230: monooxygenase FAD-binding

smcogs
  SMCOG1050: monooxygenase FAD-binding

JQS43_RS06235: monooxygenase FAD-binding

smcogs
  SMCOG1050: monooxygenase FAD-binding

JQS43_RS06245: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

JQS43_RS06280: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

JQS43_RS06295: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

JQS43_RS06325: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Transferases: acetyltransferase aminotransferase carboxylase methyltransferase sulfotransferase transferase
JQS43_RS06110: Sulfotransferase domain

extras
  Sulfotransfer_3: Sulfotransferase domain

JQS43_RS06185: acetyl-CoA acetyltransferase

smcogs
  SMCOG1124: acetyl-CoA acetyltransferase

JQS43_RS06225: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

JQS43_RS06270: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

JQS43_RS06310: O-methyltransferase

smcogs
  SMCOG1042: O-methyltransferase

JQS43_RS06315: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Lyases: cyclase
JQS43_RS06240: cyclase/dehydrase

smcogs
  SMCOG1128: cyclase/dehydrase

JQS43_RS06265: Polyketide synthesis cyclase

smcogs
  SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase
JQS43_RS06255: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

JQS43_RS06260: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T2PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.5 |  | 0.83 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000231.5 |  | 0.82 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0002070.3 |  | 0.77 | PKS | SEK90, pentangumycin | Saccharothrix espanaensis DSM 44229
BGC0001723.5 |  | 0.75 | PKS | oviedomycin | Streptomyces antibioticus
BGC0002047.2 |  | 0.60 | PKS | brasiliquinone A, brasiliquinone B | Nocardia brasiliensis
BGC0002712.2 |  | 0.59 | PKS | WS-5995 D, WS-5995 B, WS-5995 C, SEK 43 | Streptomyces yanglinensis
BGC0002369.2 |  | 0.59 | PKS | maduralactomycin A, maduralactomycin B, actinospirol A, actinospirol B | Actinomadura rubteroloni
BGC0002276.2 |  | 0.58 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0000253.4 |  | 0.57 | PKS | oviedomycin | Streptomyces antibioticus
BGC0000197.5 |  | 0.57 | PKS, saccharide | aranciamycin | Streptomyces echinatus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.5 |  | 0.83 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000231.5 |  | 0.82 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0002070.3 |  | 0.77 | PKS | SEK90, pentangumycin | Saccharothrix espanaensis DSM 44229
BGC0001723.5 |  | 0.75 | PKS | oviedomycin | Streptomyces antibioticus
BGC0002047.2 |  | 0.60 | PKS | brasiliquinone A, brasiliquinone B | Nocardia brasiliensis
BGC0002712.2 |  | 0.59 | PKS | WS-5995 D, WS-5995 B, WS-5995 C, SEK 43 | Streptomyces yanglinensis
BGC0002369.2 |  | 0.59 | PKS | maduralactomycin A, maduralactomycin B, actinospirol A, actinospirol B | Actinomadura rubteroloni
BGC0002276.2 |  | 0.58 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0000253.4 |  | 0.57 | PKS | oviedomycin | Streptomyces antibioticus
BGC0000197.5 |  | 0.57 | PKS, saccharide | aranciamycin | Streptomyces echinatus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47
Confidence: medium
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 25.01 out of 30.22
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 32.33 out of 36.53
Confidence: strong
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52
Confidence: medium
Additional weak hits (21):
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.77 out of 27.78
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.42 out of 21.55
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.12 out of 29.38
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.01 out of 27.78
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.91 out of 39.62
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.84 out of 36.54
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.22 out of 27.78
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.68 out of 27.78
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.08 out of 35.63
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.57 out of 29.65
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.76 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.71 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.63 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.25 out of 26.06
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.44 out of 36.53
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.02 out of 36.53
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.35 out of 29.65
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Type II PKS
TFBS Finder
Type II PKS gene cluster prediction details
Predictions of starter units, elongations, product classes, and potential molecular weights for type II PKS clusters.
More detailed information is available here.

Cluster section:
  1324412 to 1396892
Starter unit(s):
  acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:
  8|9 (Score: 678.1; E-value: 8.1e-207)
Product class(es):
  angucycline
Product molecular weight(s):
  acetyl-CoA_8: 382 Da
  acetyl-CoA_9: 424 Da

JQS43_RS06230
  OXY (Score: 560.2; E-value: 9.6e-171)
JQS43_RS06235
  OXY (Score: 535.1; E-value: 3.8e-163)
JQS43_RS06240
  CYC C7-C12 (Score: 474.6; E-value: 2.5e-145)
JQS43_RS06245
  KR C9 (Score: 461.8; E-value: 1.4e-141)
JQS43_RS06250
  ACP (Score: 119.0; E-value: 1.6e-37)
JQS43_RS06255
  CLF 8|9 (Score: 678.1; E-value: 8.1e-207)
JQS43_RS06260
  KS (Score: 760.7; E-value: 8.3e-232)
JQS43_RS06265
  CYC C4-C17/C2-C19 (Score: 187.6; E-value: 5.2e-58)
JQS43_RS06280
  KR (Score: 41.7; E-value: 2.4e-13)
JQS43_RS06310
  MET (Score: 293.8; E-value: 3.9e-90)

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
ClgR | Caseinolytic protease gene regulator
DmdR1 | Iron(II)-dependent repressor
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP070499.1 - Region 7 - T1PKS,oligosaccharide,t3nrps-iterative
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,453,667 - 1,584,173 nt. (total: 130,507 nt) Show pHMM detection rules used
t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
oligosaccharide: (repeatable(3, [DUF1205, Glyco_transf_28, Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT, 150))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
JQS43_RS06775: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

JQS43_RS06905: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

JQS43_RS06910: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

JQS43_RS06960: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase aminotransferase glycosyltransferase methyltransferase sulfotransferase transferase
JQS43_RS06715: Sulfotransferase domain

extras
  Sulfotransfer_1: Sulfotransferase domain

JQS43_RS06740: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

JQS43_RS06850: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

JQS43_RS06855: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

JQS43_RS06860: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

JQS43_RS06865: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

JQS43_RS06900: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

JQS43_RS06920: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

JQS43_RS06930: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

JQS43_RS06965: methyltransferase

smcogs
  SMCOG1248: methyltransferase

Hydrolases: amidase esterase hydrolase protease
JQS43_RS06665: amidase

smcogs
  SMCOG1105: amidase

JQS43_RS06680: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

JQS43_RS06730: thioesterase

smcogs
  SMCOG1004: thioesterase

JQS43_RS06735: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

Lyases: decarboxylase dehydratase
JQS43_RS06760: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

JQS43_RS06845: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

JQS43_RS06925: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase
JQS43_RS06750: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

JQS43_RS06755: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

JQS43_RS06935: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

JQS43_RS06940: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

JQS43_RS06955: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

JQS43_RS26020: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

JQS43_RS26025: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

JQS43_RS26030: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | t3nrps-iterative | T1PKS | oligosaccharide | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001273.3 |  |  |  |  | 1.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001275.3 |  |  |  |  | 1.59 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001244.3 |  |  |  |  | 1.54 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001276.3 |  |  |  |  | 1.46 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0000041.3 |  |  |  |  | 1.31 | PKS | oronofacic acid | Pseudomonas syringae
BGC0002191.2 |  |  |  |  | 1.21 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0002154.2 |  |  |  |  | 1.17 | PKS | 1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene | Pyricularia oryzae 70-15
BGC0001258.3 |  |  |  |  | 1.17 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Glarea lozoyensis
BGC0001257.3 |  |  |  |  | 1.17 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245
BGC0001160.5 |  |  |  |  | 1.16 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001273.3 |  | 0.76 | PKS | asperlactone | Aspergillus ochraceus
BGC0001276.3 |  | 0.76 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001275.3 |  | 0.75 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001244.3 |  | 0.74 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0002191.2 |  | 0.64 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0001160.5 |  | 0.64 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001258.3 |  | 0.64 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Glarea lozoyensis
BGC0000018.5 |  | 0.64 | PKS | angolamycin | Streptomyces eurythermus
BGC0002154.2 |  | 0.64 | PKS | 1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene | Pyricularia oryzae 70-15
BGC0001257.3 |  | 0.64 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.11 out of 27.55
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.79 out of 23.79
Confidence: medium
Additional weak hits (21):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.73 out of 23.43
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.41 out of 31.73
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.35 out of 27.78
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.78 out of 27.78
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.35 out of 28.14
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.63 out of 36.54
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.52 out of 31.73
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.57 out of 36.54
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.59 out of 30.97
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.90 out of 29.25
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.09 out of 31.73
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.50 out of 24.78
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.40 out of 32.93
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.89 out of 23.43
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.54 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.12 out of 36.54
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.36 out of 32.93
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.81 out of 33.14
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.34 out of 28.19
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.48 out of 27.18
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 1453666 - 1584173:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ccmal - ccmal - ccmal) + (ccmal) + (ccmal) + (ohmal) + (ccmal - ccmal) + (ccmal - mal)
Non-colinear ordering:
  JQS43_RS26020 + JQS43_RS26025 + JQS43_RS26030 + JQS43_RS06940 + JQS43_RS06955 + JQS43_RS06960

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 1453666 - 1528705:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ccmal - ccmal - ccmal) + (ccmal) + (ccmal)
Non-colinear ordering:
  JQS43_RS26020 + JQS43_RS26025 + JQS43_RS26030

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 10, location 1518691 - 1584173:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal) + (ccmal - ccmal) + (ccmal - mal)
Non-colinear ordering:
  JQS43_RS06940 + JQS43_RS06955 + JQS43_RS06960

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
JQS43_RS06740: pk
PKS_AT (10..279): pk
ATSignature: (unknown)
No matches above 50%
minowa: trans-1,2-CPDA

Prediction, score:
  trans-1,2-CPDA: 0.0
  inactive: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Methylmalonyl-CoA: 0.0
  Methoxymalonyl-CoA: 0.0
  Malonyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

JQS43_RS06750: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (30..434): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    YVLFFDCAMFDCFSFFAGEENLYGPTELTITISG
  Nearest Stachelhaus code(s):
    Ala DCFFFALITK (91% 8Å match)
    bMe-Asp DCFFFALITK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

JQS43_RS06755: X
AMP-binding (19..412): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    AAIFWDYGLYKLPVTNTGAVRQFGQTECKRVSIM
  Nearest Stachelhaus code(s):
    3S-Abu DYYPTTQRIK (85% 8Å match)
    Asp DYYPTTMRVK (74% 8Å match)
  Stachelhaus code match:
    90% (moderate)

JQS43_RS26020: mal - mal - mal
PKS_AT (662..953): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 205.2
  inactive: 112.9
  Methoxymalonyl-CoA: 73.0
  Methylmalonyl-CoA: 60.3
  Propionyl-CoA: 36.0
  Isobutyryl-CoA: 29.8
  Ethylmalonyl-CoA: 20.3
  2-Methylbutyryl-CoA: 19.0
  Acetyl-CoA: 16.7
  Benzoyl-CoA: 13.9
  CHC-CoA: 13.0
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  3-Methylbutyryl-CoA: 0.0

PKS_AT (2441..2644): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 70.8%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 82.4
  inactive: 29.8
  Methylmalonyl-CoA: 25.4
  Methoxymalonyl-CoA: 22.5
  fatty_acid: 15.3
  Benzoyl-CoA: 14.1
  Isobutyryl-CoA: 13.8
  CHC-CoA: 12.7
  Propionyl-CoA: 12.1
  2-Methylbutyryl-CoA: 9.6
  Ethylmalonyl-CoA: 8.2
  trans-1,2-CPDA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

PKS_AT (4146..4349): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 70.8%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 82.4
  inactive: 29.8
  Methylmalonyl-CoA: 25.4
  Methoxymalonyl-CoA: 22.5
  fatty_acid: 15.3
  Benzoyl-CoA: 14.1
  Isobutyryl-CoA: 13.8
  CHC-CoA: 12.7
  Propionyl-CoA: 12.1
  2-Methylbutyryl-CoA: 9.6
  Ethylmalonyl-CoA: 8.2
  trans-1,2-CPDA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

JQS43_RS26025: mal
PKS_AT (574..858): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 70.8%
  2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 151.8
  inactive: 71.5
  Methoxymalonyl-CoA: 43.6
  Methylmalonyl-CoA: 37.3
  Ethylmalonyl-CoA: 16.9
  fatty_acid: 16.8
  Propionyl-CoA: 16.5
  Benzoyl-CoA: 14.4
  Isobutyryl-CoA: 14.1
  Acetyl-CoA: 10.9
  CHC-CoA: 10.2
  2-Methylbutyryl-CoA: 9.3
  trans-1,2-CPDA: 0.0
  3-Methylbutyryl-CoA: 0.0

JQS43_RS26030: mal
PKS_AT (1385..1670): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 70.8%
  2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 151.8
  inactive: 71.5
  Methoxymalonyl-CoA: 43.6
  Methylmalonyl-CoA: 37.3
  Ethylmalonyl-CoA: 16.9
  fatty_acid: 16.8
  Propionyl-CoA: 16.5
  Benzoyl-CoA: 14.4
  Isobutyryl-CoA: 14.1
  Acetyl-CoA: 10.9
  CHC-CoA: 10.2
  2-Methylbutyryl-CoA: 9.3
  trans-1,2-CPDA: 0.0
  3-Methylbutyryl-CoA: 0.0

JQS43_RS06940: mal
PKS_AT (573..858): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 70.8%
  2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 151.8
  inactive: 71.5
  Methoxymalonyl-CoA: 43.6
  Methylmalonyl-CoA: 37.3
  Ethylmalonyl-CoA: 16.9
  fatty_acid: 16.8
  Propionyl-CoA: 16.5
  Benzoyl-CoA: 14.4
  Isobutyryl-CoA: 14.1
  Acetyl-CoA: 10.9
  CHC-CoA: 10.2
  2-Methylbutyryl-CoA: 9.3
  trans-1,2-CPDA: 0.0
  3-Methylbutyryl-CoA: 0.0

JQS43_RS06955: mal - mal
PKS_AT (579..782): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 70.8%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 82.4
  inactive: 29.8
  Methylmalonyl-CoA: 25.4
  Methoxymalonyl-CoA: 22.5
  fatty_acid: 15.3
  Benzoyl-CoA: 14.1
  Isobutyryl-CoA: 13.8
  CHC-CoA: 12.7
  Propionyl-CoA: 12.1
  2-Methylbutyryl-CoA: 9.6
  Ethylmalonyl-CoA: 8.2
  trans-1,2-CPDA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

PKS_AT (2229..2518): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 95.8%
  inactive: 79.2%
  Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 191.0
  inactive: 91.7
  Methoxymalonyl-CoA: 69.9
  Methylmalonyl-CoA: 64.4
  Propionyl-CoA: 29.4
  Isobutyryl-CoA: 23.7
  Ethylmalonyl-CoA: 21.5
  Benzoyl-CoA: 20.6
  Acetyl-CoA: 20.6
  CHC-CoA: 19.7
  fatty_acid: 17.0
  2-Methylbutyryl-CoA: 14.7
  trans-1,2-CPDA: 9.4
  3-Methylbutyryl-CoA: 0.0

JQS43_RS06960: mal - mal
PKS_AT (551..830): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 70.8%
  Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 196.1
  inactive: 89.3
  Methoxymalonyl-CoA: 73.1
  Methylmalonyl-CoA: 64.4
  Propionyl-CoA: 30.8
  Isobutyryl-CoA: 24.5
  Acetyl-CoA: 20.1
  Ethylmalonyl-CoA: 19.3
  2-Methylbutyryl-CoA: 13.4
  trans-1,2-CPDA: 13.2
  Benzoyl-CoA: 12.4
  CHC-CoA: 11.3
  fatty_acid: 9.7
  3-Methylbutyryl-CoA: 0.0

PKS_AT (2280..2570): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 66.7%
  inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 110.1
  inactive: 44.8
  Methylmalonyl-CoA: 41.5
  Methoxymalonyl-CoA: 40.1
  2-Methylbutyryl-CoA: 21.5
  Isobutyryl-CoA: 20.9
  Propionyl-CoA: 20.3
  Ethylmalonyl-CoA: 20.2
  CHC-CoA: 17.6
  Benzoyl-CoA: 17.4
  fatty_acid: 15.4
  Acetyl-CoA: 14.0
  trans-1,2-CPDA: 12.8
  3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism

NZ_CP070499.1 - Region 8 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,812,217 - 1,833,293 nt. (total: 21,077 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
JQS43_RS08235: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Ligases: synthetase
JQS43_RS08270: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.5 |  | 0.51 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.46 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000501.3 |  | 0.45 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001555.4 |  | 0.41 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000584.5 |  | 0.40 | ribosomal | colicin V | Escherichia coli
BGC0002447.3 |  | 0.40 | ribosomal | cerecyclin | Bacillus cereus
BGC0000504.5 |  | 0.40 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.5 |  | 0.51 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.46 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000501.3 |  | 0.45 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001555.4 |  | 0.41 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000584.5 |  | 0.40 | ribosomal | colicin V | Escherichia coli
BGC0002447.3 |  | 0.40 | ribosomal | cerecyclin | Bacillus cereus
BGC0000504.5 |  | 0.40 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
JQS43_RS08270: PT_FPPS_like
Domain 1 (43 - 337): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 27.04
Confidence: medium
Additional weak hits (1):
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.42 out of 20.97
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
DasR | N-acetylglucosamine dependent repressor

NZ_CP070499.1 - Region 9 - NRPS,NRPS-like,T1PKS,T2PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,866,520 - 1,980,978 nt. (total: 114,459 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
T2PKS: (t2ks and t2clf)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
JQS43_RS08545: flavin reductase domain protein FMN-binding

smcogs
  SMCOG1160: flavin reductase domain protein FMN-binding

JQS43_RS08555: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

JQS43_RS08655: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

JQS43_RS08690: acyl-CoA dehydrogenase type 2

smcogs
  SMCOG1191: acyl-CoA dehydrogenase type 2

JQS43_RS08695: acyl-CoA dehydrogenase type 2

smcogs
  SMCOG1191: acyl-CoA dehydrogenase type 2

Transferases: carboxylase halogenase methyltransferase transferase
JQS43_RS08450: methyltransferase

smcogs
  SMCOG1089: methyltransferase

JQS43_RS08540: conventional flavin-dependent halogenase

halogenases
  conventional flavin-dependent halogenase
smcogs
  SMCOG1119: halogenase

JQS43_RS08625: O-methyltransferase

smcogs
  SMCOG1042: O-methyltransferase

JQS43_RS08705: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

JQS43_RS08715: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: esterase
JQS43_RS08505: thioesterase

smcogs
  SMCOG1004: thioesterase

Lyases: cyclase
JQS43_RS08685: cyclase/dehydrase

smcogs
  SMCOG1128: cyclase/dehydrase

JQS43_RS08700: Polyketide synthesis cyclase

smcogs
  SMCOG1225: Polyketide synthesis cyclase

Ligases: ligase synthase
JQS43_RS08495: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

JQS43_RS08500: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

JQS43_RS08510: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

JQS43_RS08515: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

JQS43_RS08520: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

JQS43_RS08670: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

JQS43_RS08675: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

JQS43_RS08830: pseudouridine synthase

smcogs
  SMCOG1279: pseudouridine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | NRPS | T1PKS | T2PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001249.5 |  |  |  |  | 1.23 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001132.4 |  |  |  |  | 1.09 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002164.2 |  |  |  |  | 1.08 | NRPS | peramine | Epichloe festucae
BGC0001128.4 |  |  |  |  | 1.07 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3 |  |  |  |  | 1.06 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  |  |  |  | 1.04 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002286.3 |  |  |  |  | 1.04 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  |  |  |  | 1.01 | NRPS | enniatin | Fusarium equiseti
BGC0001758.4 |  |  |  |  | 0.99 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002135.2 |  |  |  |  | 0.99 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.73 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0000272.3 |  | 0.71 | PKS | spore pigment | Streptomyces collinus
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002164.2 |  | 0.69 | NRPS | peramine | Epichloe festucae
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0002286.3 |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0001135.5 |  | 0.69 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.54 out of 23.79
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.94 out of 23.79
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.94 out of 23.79
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47
Confidence: medium
Additional weak hits (18):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.63 out of 31.73
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.81 out of 39.62
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.04 out of 29.25
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.71 out of 20.97
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.04 out of 29.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.04 out of 29.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.04 out of 29.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.04 out of 29.25
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.59 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.79 out of 26.06
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.34 out of 29.51
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.67 out of 29.38
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.19 out of 28.19
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.63 out of 35.63
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.12 out of 36.53
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.85 out of 28.19
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.67 out of 32.93
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Type II PKS
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 12, location 1866519 - 1980978:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X) + (ccmal) + (Gly - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 13, location 1866519 - 1908688:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X) + (ccmal) + (Gly - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 14, location 1873045 - 1930949:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X) + (ccmal) + (Gly - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 15, location 1908465 - 1980978:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
JQS43_RS08495: X
AMP-binding (121..479): X
nrpys: Orn, Lys, Arg

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    GNHTYDMSVSDGHSLLGGEVNGYGATEVSFTVQL
  Nearest Stachelhaus code(s):
    Hpg DALHLGLFCK (38% 8Å match)
    Phe DMSEVGCFCK (35% 8Å match)
  Stachelhaus code match:
    60% (weak)

JQS43_RS08510: X
AMP-binding (13..405): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGCNFDAATFDVVVLSGGDFDVYGPTEATVCQVV
  Nearest Stachelhaus code(s):
    Phe DAFVLSAVCK (53% 8Å match)
    ndmHex DAMVLGVVAK (47% 8Å match)
  Stachelhaus code match:
    80% (moderate)

JQS43_RS08515: mal
PKS_AT (532..813): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 87.5%
  2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 172.6
  inactive: 95.2
  Methoxymalonyl-CoA: 67.3
  Methylmalonyl-CoA: 62.2
  Propionyl-CoA: 50.5
  2-Methylbutyryl-CoA: 38.4
  Isobutyryl-CoA: 36.1
  Ethylmalonyl-CoA: 35.7
  fatty_acid: 25.3
  Acetyl-CoA: 22.7
  CHC-CoA: 19.5
  Benzoyl-CoA: 19.5
  trans-1,2-CPDA: 16.0
  3-Methylbutyryl-CoA: 8.8

JQS43_RS08520: Gly - X
Search NORINE for peptide: strict or relaxed
AMP-binding (944..1316): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWFTFDIAVLELQALCGGEWNVYGPTETTVWSAA
  Nearest Stachelhaus code(s):
    Gly DILQLGVVWK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2040..2446): X
nrpys: Tyr, bOH-Tyr

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSFPFDASVGDPDAMVGGEVNHYGPTEATVCATT
  Nearest Stachelhaus code(s):
    N6-ohLys DALHPGHVCK (65% 8Å match)
    CysA DATKMGHVGK (62% 8Å match)
  Stachelhaus code match:
    70% (weak)

Link to PARAS substrate predictor
Type II PKS gene cluster prediction details
Predictions of starter units, elongations, product classes, and potential molecular weights for type II PKS clusters.
More detailed information is available here.

Cluster section:
  1908465 to 1980978
Starter unit(s):
  acetyl-CoA (Score: 0.0; E-value: 0)
Product class(es):
  pentangular polyphenol
  tetracenomycin

JQS43_RS08525
  OXY (Score: 76.4; E-value: 5.2e-24)
JQS43_RS08625
  MET (Score: 163.0; E-value: 2.3e-50)
JQS43_RS08665
  CYC C5-C18 (Score: 205.3; E-value: 6.2e-64)
JQS43_RS08670
  KS (Score: 704.4; E-value: 1e-214)
JQS43_RS08675
  CLF (Score: 537.4; E-value: 4.8e-164)
JQS43_RS08680
  ACP (Score: 53.2; E-value: 5.3e-17)
JQS43_RS08685
  CYC C9-C14 (Score: 244.0; E-value: 1.1e-75)
JQS43_RS08700
  CYC C4-C21/C2-C23|C2-C19 (Score: 139.0; E-value: 1.2e-43)
JQS43_RS08725
  MET (Score: 34.7; E-value: 2.3e-11)

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
IolR | Regulator of the inositol catabolism
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP070499.1 - Region 10 - lanthipeptide-class-iv
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,324,537 - 2,347,260 nt. (total: 22,724 nt) Show pHMM detection rules used
lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase
JQS43_RS10360: FAD linked oxidase domain protein

smcogs
  SMCOG1138: FAD linked oxidase domain protein

Isomerases: racemase
JQS43_RS10385: mandelate racemase/muconate lactonizing enzyme

smcogs
  SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Translocases: transporter
JQS43_RS10405: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iv | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000563.4 |  | 0.53 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001226.4 |  | 0.53 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0002700.2 |  | 0.49 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000519.4 |  | 0.48 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0002111.3 |  | 0.46 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0002701.2 |  | 0.43 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0000518.3 |  | 0.42 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000495.5 |  | 0.36 | ribosomal | actagardine | Actinoplanes garbadinensis
BGC0001582.4 |  | 0.36 | NRPS | ecumicin | Nonomuraea sp. MJM5123
BGC0002657.2 |  | 0.35 | NRPS, PKS | deoxyhangtaimycin | Streptomyces spectabilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000563.4 |  | 0.53 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001226.4 |  | 0.53 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0002700.2 |  | 0.49 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000519.4 |  | 0.48 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0002111.3 |  | 0.46 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0002701.2 |  | 0.43 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0000518.3 |  | 0.42 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000495.5 |  | 0.36 | ribosomal | actagardine | Actinoplanes garbadinensis
BGC0001582.4 |  | 0.36 | NRPS | ecumicin | Nonomuraea sp. MJM5123
BGC0002657.2 |  | 0.35 | NRPS, PKS | deoxyhangtaimycin | Streptomyces spectabilis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lanthipeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47
Confidence: medium
Additional weak hits (2):
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.60 out of 21.84
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.93 out of 28.19
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP070499.1 - Region 11 - ectoine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,544,209 - 2,554,583 nt. (total: 10,375 nt) Show pHMM detection rules used
ectoine: ectoine_synt

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
JQS43_RS11250: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: PPTase
JQS43_RS11275: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1060: 4'-phosphopantetheinyl transferase

Ligases: ligase
JQS43_RS11225: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ectoine | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.5 |  | 0.53 | other (other) | showdomycin | Streptomyces showdoensis
BGC0000859.3 |  | 0.49 | other (other) | ectoine | Methylomicrobium alcaliphilum
BGC0000857.3 |  | 0.49 | other (other) | ectoine | Methylophaga alcalica
BGC0000854.3 |  | 0.46 | other (other) | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000343.5 |  | 0.45 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0000706.3 |  | 0.45 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000131.5 |  | 0.45 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0002097.3 |  | 0.43 | NRPS, PKS, saccharide | kosinostatin | Micromonospora sp. 28ISP2-46
BGC0001073.5 |  | 0.42 | NRPS, PKS | kosinostatin | Micromonospora sp. TP-A0468
BGC0001517.3 |  | 0.40 | NRPS | asperphenamate | Aspergillus terreus NIH2624

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.5 |  | 0.53 | other (other) | showdomycin | Streptomyces showdoensis
BGC0000859.3 |  | 0.49 | other (other) | ectoine | Methylomicrobium alcaliphilum
BGC0000857.3 |  | 0.49 | other (other) | ectoine | Methylophaga alcalica
BGC0000854.3 |  | 0.46 | other (other) | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000343.5 |  | 0.45 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0000706.3 |  | 0.45 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000131.5 |  | 0.45 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0002097.3 |  | 0.43 | NRPS, PKS, saccharide | kosinostatin | Micromonospora sp. 28ISP2-46
BGC0001073.5 |  | 0.42 | NRPS, PKS | kosinostatin | Micromonospora sp. TP-A0468
BGC0001517.3 |  | 0.40 | NRPS | asperphenamate | Aspergillus terreus NIH2624

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (2):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.57 out of 26.33
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.92 out of 32.93
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP070499.1 - Region 12 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,565,925 - 2,578,192 nt. (total: 12,268 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: methyltransferase
JQS43_RS11360: methyltransferase

smcogs
  SMCOG1248: methyltransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.46 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002144.3 |  | 0.41 | ribosomal | phazolicin | Rhizobium sp. Pop5
BGC0001555.4 |  | 0.41 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002584.2 |  | 0.40 | ribosomal | azolemycin B, azolemycin A, azolemycin D, azolemycin C | Streptomyces sp. FXJ1.264
BGC0000584.5 |  | 0.40 | ribosomal | colicin V | Escherichia coli
BGC0001928.2 |  | 0.39 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002488.3 |  | 0.39 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002568.2 |  | 0.39 | other (other) | Ethylenediaminesuccinic acid hydroxyarginine | Streptomyces scabiei 87.22
BGC0000589.5 |  | 0.38 | ribosomal | microcin M | Escherichia coli Nissle 1917
BGC0000588.5 |  | 0.38 | ribosomal | microcin L | Escherichia coli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.46 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002144.3 |  | 0.41 | ribosomal | phazolicin | Rhizobium sp. Pop5
BGC0001555.4 |  | 0.41 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002584.2 |  | 0.40 | ribosomal | azolemycin B, azolemycin A, azolemycin D, azolemycin C | Streptomyces sp. FXJ1.264
BGC0000584.5 |  | 0.40 | ribosomal | colicin V | Escherichia coli
BGC0001928.2 |  | 0.39 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002488.3 |  | 0.39 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002568.2 |  | 0.39 | other (other) | Ethylenediaminesuccinic acid hydroxyarginine | Streptomyces scabiei 87.22
BGC0000589.5 |  | 0.38 | ribosomal | microcin M | Escherichia coli Nissle 1917
BGC0000588.5 |  | 0.38 | ribosomal | microcin L | Escherichia coli

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.31 out of 28.19
Confidence: medium
Additional weak hits (6):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.88 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.12 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.20 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.82 out of 29.38
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.60 out of 20.97
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.52 out of 28.19
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ZuR variant 1 | Zinc-responsive repressor

NZ_CP070499.1 - Region 13 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,844,977 - 2,856,212 nt. (total: 11,236 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001485.4 |  | 0.42 | other (other) | chuangxinmycin | Actinoplanes tsinanensis
BGC0000598.5 |  | 0.39 | ribosomal | polytheonamide A, polytheonamide B | Candidatus Entotheonella factor
BGC0000468.5 |  | 0.38 | ribosomal | bottromycin A2 | Streptomyces bottropensis DSM40262
BGC0001157.6 |  | 0.38 | ribosomal | bottromycin A2 | Streptomyces scabiei 87.22
BGC0000470.6 |  | 0.37 | ribosomal | bottromycin D | Streptomyces sp. WMMB272
BGC0000469.6 |  | 0.36 | ribosomal | bottromycin A2 | Streptomyces sp. BC16019
BGC0001753.3 |  | 0.31 | ribosomal | radamycin, globimycin | Streptomyces globisporus subsp. globisporus
BGC0001148.5 |  | 0.30 | NRPS, ribosomal | pheganomycin | Streptomyces cirratus
BGC0001797.3 |  | 0.29 | ribosomal | telomestatin | Streptomyces anulatus
BGC0000986.5 |  | 0.24 | NRPS, PKS | dkxanthene 530, dkxanthene 556, dkxanthene, dkxanthene 504, dkxanthene 508, dkxanthene 518, dkxanthene 520, dkxanthene 534, dkxanthene 544, dkxanthene 548, dkxanthene 560, dkxanthene 574, dkxanthene 586 | Stigmatella aurantiaca DW4/3-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001485.4 |  | 0.42 | other (other) | chuangxinmycin | Actinoplanes tsinanensis
BGC0000598.5 |  | 0.39 | ribosomal | polytheonamide A, polytheonamide B | Candidatus Entotheonella factor
BGC0000468.5 |  | 0.38 | ribosomal | bottromycin A2 | Streptomyces bottropensis DSM40262
BGC0001157.6 |  | 0.38 | ribosomal | bottromycin A2 | Streptomyces scabiei 87.22
BGC0000470.6 |  | 0.37 | ribosomal | bottromycin D | Streptomyces sp. WMMB272
BGC0000469.6 |  | 0.36 | ribosomal | bottromycin A2 | Streptomyces sp. BC16019
BGC0001753.3 |  | 0.31 | ribosomal | radamycin, globimycin | Streptomyces globisporus subsp. globisporus
BGC0001148.5 |  | 0.30 | NRPS, ribosomal | pheganomycin | Streptomyces cirratus
BGC0001797.3 |  | 0.29 | ribosomal | telomestatin | Streptomyces anulatus
BGC0000986.5 |  | 0.24 | NRPS, PKS | dkxanthene 530, dkxanthene 556, dkxanthene, dkxanthene 504, dkxanthene 508, dkxanthene 518, dkxanthene 520, dkxanthene 534, dkxanthene 544, dkxanthene 548, dkxanthene 560, dkxanthene 574, dkxanthene 586 | Stigmatella aurantiaca DW4/3-1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52
Confidence: medium
Additional weak hits (1):
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.34 out of 29.51
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production

NZ_CP070499.1 - Region 14 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,030,572 - 3,053,977 nt. (total: 23,406 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001171.5 |  | 0.51 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0001170.5 |  | 0.51 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.5 |  | 0.50 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0000566.5 |  | 0.50 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0002115.3 |  | 0.49 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0000569.5 |  | 0.47 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0001173.5 |  | 0.46 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0002447.3 |  | 0.45 | ribosomal | cerecyclin | Bacillus cereus
BGC0002656.2 |  | 0.44 | PKS | oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B | Streptacidiphilus oryzae TH49
BGC0000528.5 |  | 0.44 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001171.5 |  | 0.51 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0001170.5 |  | 0.51 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.5 |  | 0.50 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0000566.5 |  | 0.50 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0002115.3 |  | 0.49 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0000569.5 |  | 0.47 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0001173.5 |  | 0.46 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0002447.3 |  | 0.45 | ribosomal | cerecyclin | Bacillus cereus
BGC0002656.2 |  | 0.44 | PKS | oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B | Streptacidiphilus oryzae TH49
BGC0000528.5 |  | 0.44 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (3030571...3053977)
JQS43_RS13505
  RRE type: Cytolysin_C_RRE
  Location: 12 - 98
  Score: 48.2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CP070499.1 - Region 15 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,169,163 - 3,198,932 nt. (total: 29,770 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
JQS43_RS14110: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

JQS43_RS14140: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Lyases: decarboxylase
JQS43_RS14105: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000941.3 |  | 0.74 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2 |  | 0.68 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0001478.5 |  | 0.66 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0001572.3 |  | 0.66 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000940.5 |  | 0.61 | other (other) | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001453.5 |  | 0.61 | other (other) | desferrioxamine | Streptomyces argillaceus
BGC0002464.3 |  | 0.59 | other (other) | alcaligin | Bordetella pertussis Tohama I
BGC0002690.2 |  | 0.55 | other (other) | FW0622 | Verrucosispora sp. FIM060022
BGC0002620.2 |  | 0.52 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0001531.5 |  | 0.49 | other (other) | bisucaberin B | Tenacibaculum mesophilum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000941.3 |  | 0.74 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2 |  | 0.68 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0001478.5 |  | 0.66 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0001572.3 |  | 0.66 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000940.5 |  | 0.61 | other (other) | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001453.5 |  | 0.61 | other (other) | desferrioxamine | Streptomyces argillaceus
BGC0002464.3 |  | 0.59 | other (other) | alcaligin | Bordetella pertussis Tohama I
BGC0002690.2 |  | 0.55 | other (other) | FW0622 | Verrucosispora sp. FIM060022
BGC0002620.2 |  | 0.52 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0001531.5 |  | 0.49 | other (other) | bisucaberin B | Tenacibaculum mesophilum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.52 out of 19.26
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 34.36 out of 36.53
Confidence: strong
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.80 out of 27.04
Confidence: medium
Additional weak hits (2):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.08 out of 21.55
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.07 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
DasR | N-acetylglucosamine dependent repressor
DmdR1 | Iron(II)-dependent repressor

NZ_CP070499.1 - Region 16 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,223,045 - 3,248,160 nt. (total: 25,116 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase dehydratase
JQS43_RS14390: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

JQS43_RS14395: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0001289.5 |  | 0.47 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000560.5 |  | 0.45 | ribosomal | subtilomycin | Bacillus subtilis
BGC0002635.2 |  | 0.44 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0000541.5 |  | 0.44 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0001727.3 |  | 0.42 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0002120.3 |  | 0.40 | ribosomal | nocathioamide A | Nocardia terpenica IFM 0706
BGC0000529.5 |  | 0.38 | ribosomal | microbisporicin A2 | Microbispora corallina
BGC0000204.5 |  | 0.36 | PKS | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0002064.2 |  | 0.36 | ribosomal | felipeptin A2, felipeptin A1 | Amycolatopsis sp. YIM 10

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0001289.5 |  | 0.47 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000560.5 |  | 0.45 | ribosomal | subtilomycin | Bacillus subtilis
BGC0002635.2 |  | 0.44 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0000541.5 |  | 0.44 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0001727.3 |  | 0.42 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0002120.3 |  | 0.40 | ribosomal | nocathioamide A | Nocardia terpenica IFM 0706
BGC0000529.5 |  | 0.38 | ribosomal | microbisporicin A2 | Microbispora corallina
BGC0000204.5 |  | 0.36 | PKS | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0002064.2 |  | 0.36 | ribosomal | felipeptin A2, felipeptin A1 | Amycolatopsis sp. YIM 10

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for JQS43_RS14390

JQS43_RS14385
Leader:
MSNALDQTDTTKSHPA
Core:
R D G E Q A G A D D W E L D I K F I E A G D A V K H L I Y M T N D Q C G T T C Q S A C T N T C P S
Core with dehydrations:
R D G E Q A G A D D W E L D I K F I E A G D A V K H L I Y M Dhb N D Q Cys G Dhb Dhb Cys Q Dha A Cys Dhb N Dhb Cys P Dha

#### antiSMASH-DB 4.0 matches for JQS43_RS14385

100.0%
NZ_CP070499.1 and 1 other:
NZ_CP070499.1 Lanthipeptides: JQS43_RS14385_lanthipeptide
Lanthipeptides: JQS43_RS14385_lanthipeptide
1
R D G E Q A G A D D W E L D I K F I E A G D A V K H L I Y M T N D Q C G T T C Q S A C T N T C P S
49
R D G E Q A G A D D W E L D I K F I E A G D A V K H L I Y M T N D Q C G T T C Q S A C T N T C P S
1
R D G E Q A G A D D W E L D I K F I E A G D A V K H L I Y M T N D Q C G T T C Q S A C T N T C P S
49
59.2%
NZ_LT607413.1 and 1 other:
NZ_LT607413.1 Lanthipeptides: GA0070618_RS10945_lanthipeptide
Lanthipeptides: GA0070618_RS10945_lanthipeptide
10
D W E L D I K F I E A G D A V K H L I Y M T N D Q C G T T C Q S A C T N T C P S
49
D W E L D I F I E+G++V L I Y M T N D C G T C Q S A C+ T C P+
1
D W E L D I T F I E S G E S V D K L I Y M T N D G C G K T C Q S A C S T T C P A
40
38.8%
NC_007777.1 and 1 other:
NC_007777.1 Lanthipeptides: FRANCCI3_RS09160_lanthipeptide
Lanthipeptides: FRANCCI3_RS09160_lanthipeptide
24
V K H L I Y M T N D Q C G T T C Q S A C T N T C P
48
V+ L I M T+D C G T T C Q S A C N T C P
2
V E E L I R M T D D G C G T T C Q S A C P N T C P
26
with 177 more sequence matches
Only the first 10 are displayed here.
34.7%
NZ_BMMN01000001.1 and 1 other:
NZ_BMMN01000001.1 Lanthipeptides: IEY80_RS02165_lanthipeptide
Lanthipeptides: IEY80_RS02165_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G T T C Q S A C+ T C P
1
K L I R M T D D G C G T T C Q S A C S T T C P
23
34.7%
NZ_JACHGT010000013.1 and 1 other:
NZ_JACHGT010000013.1 Lanthipeptides: HNR73_RS27205_lanthipeptide
Lanthipeptides: HNR73_RS27205_lanthipeptide
27
L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I+M T N D C G T C Q S A C+ T C P
2
L I H M T N D G C G Q T C Q S A C S T T C P
23
32.7%
NZ_CP026652.1 and 1 other:
NZ_CP026652.1 Lanthipeptides: C4B68_RS00400_lanthipeptide
Lanthipeptides: C4B68_RS00400_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I +T N D C G+T C Q S A C T +C P
1
Q L I R L T N D G C G S T C Q S A C T-S C P
22
32.7%
NZ_CP054916.1 and 1 other:
NZ_CP054916.1 Lanthipeptides: HUT19_RS32830_lanthipeptide
Lanthipeptides: HUT19_RS32830_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G T C Q S A C+ T C P
1
R L I R M T D D G C G Q T C Q S A C S T T C P
23
32.7%
NZ_CP119145.1 and 1 other:
NZ_CP119145.1 Lanthipeptides: PZB75_RS00285_lanthipeptide
Lanthipeptides: PZB75_RS00285_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G+T C Q S A C+ T C P
1
R L I Q M T D D G C G S T C Q S A C S T T C P
23
32.7%
NZ_JABBWZ010000004.1 and 4 others:
NZ_JABBWZ010000004.1 Lanthipeptides: HHX40_RS10860_lanthipeptide NZ_JABBWZ010000004.1 Lanthipeptides: HHX40_RS10860_lanthipeptide NZ_VYTZ01000008.1 Lanthipeptides: F5972_RS22705_lanthipeptide NZ_VYTZ01000008.1 Lanthipeptides: F5972_RS22705_lanthipeptide
Lanthipeptides: HHX40_RS10860_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G T+C Q S A C T C P
1
K L I R M T D D G C G T S C Q S A C P A T C P
23
32.7%
NZ_WBMT01000015.1 and 1 other:
NZ_WBMT01000015.1 Lanthipeptides: F8566_RS30065_lanthipeptide
Lanthipeptides: F8566_RS30065_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C
47
L I M T+D C G T C Q S A C N T C
1
R L I R M T D D G C G K T C Q S A C P N T C
22
30.6%
NC_007777.1 and 1 other:
NC_007777.1 Lanthipeptides: FRANCCI3_RS10225_lanthipeptide
Lanthipeptides: FRANCCI3_RS10225_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G T T C++A C+ T C P
1
R L I R M T D D G C G T T C E T A C S T T C P
23
30.6%
NZ_AP024745.1 and 1 other:
NZ_AP024745.1 Lanthipeptides: L3i22_RS11845_lanthipeptide
Lanthipeptides: L3i22_RS11845_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T
44
H+I M T D C G T T C Q S A C T
1
H I I K M T G D N C G T T C Q S A C T
19
30.6%
NZ_CM000913.1 and 7 others:
NZ_CM000913.1 Lanthipeptides: SCLAV_RS11700_lanthipeptide NZ_CP016559.1 Lanthipeptides: BB341_RS16135_lanthipeptide NZ_CP016559.1 Lanthipeptides: BB341_RS16135_lanthipeptide NZ_CP042266.1 Lanthipeptides: FQU76_RS24360_lanthipeptide NZ_CP042266.1 Lanthipeptides: FQU76_RS24360_lanthipeptide NZ_CP070379.1 Lanthipeptides: JVE63_RS07215_lanthipeptide NZ_CP070379.1 Lanthipeptides: JVE63_RS07215_lanthipeptide
Lanthipeptides: SCLAV_RS11700_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G T C+S A C+ T C P
1
R L I R M T D D G C G V T C E S A C S T T C P
23

#### MIBiG 4.0 matches for JQS43_RS14385

26.5%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
L D I K F I E A G D A V K H L I Y M T N D Q C G T T-C Q S A C
43
L I I+A G A V ++ C T T C S C
10
L G I V A I Q A G V A V G----V S A A F C P T T K C T S R C
37

#### Lanthipeptide(s) for JQS43_RS14400

JQS43_RS14385
Leader:
MSNALDQTDTTKSHPA
Core:
R D G E Q A G A D D W E L D I K F I E A G D A V K H L I Y M T N D Q C G T T C Q S A C T N T C P S
Core with dehydrations:
R D G E Q A G A D D W E L D I K F I E A G D A V K H L I Y M Dhb N D Q Cys G Dhb Dhb Cys Q Dha A Cys Dhb N Dhb Cys P Dha

#### antiSMASH-DB 4.0 matches for JQS43_RS14385

100.0%
NZ_CP070499.1 and 1 other:
NZ_CP070499.1 Lanthipeptides: JQS43_RS14385_lanthipeptide
Lanthipeptides: JQS43_RS14385_lanthipeptide
1
R D G E Q A G A D D W E L D I K F I E A G D A V K H L I Y M T N D Q C G T T C Q S A C T N T C P S
49
R D G E Q A G A D D W E L D I K F I E A G D A V K H L I Y M T N D Q C G T T C Q S A C T N T C P S
1
R D G E Q A G A D D W E L D I K F I E A G D A V K H L I Y M T N D Q C G T T C Q S A C T N T C P S
49
59.2%
NZ_LT607413.1 and 1 other:
NZ_LT607413.1 Lanthipeptides: GA0070618_RS10945_lanthipeptide
Lanthipeptides: GA0070618_RS10945_lanthipeptide
10
D W E L D I K F I E A G D A V K H L I Y M T N D Q C G T T C Q S A C T N T C P S
49
D W E L D I F I E+G++V L I Y M T N D C G T C Q S A C+ T C P+
1
D W E L D I T F I E S G E S V D K L I Y M T N D G C G K T C Q S A C S T T C P A
40
38.8%
NC_007777.1 and 1 other:
NC_007777.1 Lanthipeptides: FRANCCI3_RS09160_lanthipeptide
Lanthipeptides: FRANCCI3_RS09160_lanthipeptide
24
V K H L I Y M T N D Q C G T T C Q S A C T N T C P
48
V+ L I M T+D C G T T C Q S A C N T C P
2
V E E L I R M T D D G C G T T C Q S A C P N T C P
26
with 177 more sequence matches
Only the first 10 are displayed here.
34.7%
NZ_BMMN01000001.1 and 1 other:
NZ_BMMN01000001.1 Lanthipeptides: IEY80_RS02165_lanthipeptide
Lanthipeptides: IEY80_RS02165_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G T T C Q S A C+ T C P
1
K L I R M T D D G C G T T C Q S A C S T T C P
23
34.7%
NZ_JACHGT010000013.1 and 1 other:
NZ_JACHGT010000013.1 Lanthipeptides: HNR73_RS27205_lanthipeptide
Lanthipeptides: HNR73_RS27205_lanthipeptide
27
L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I+M T N D C G T C Q S A C+ T C P
2
L I H M T N D G C G Q T C Q S A C S T T C P
23
32.7%
NZ_CP026652.1 and 1 other:
NZ_CP026652.1 Lanthipeptides: C4B68_RS00400_lanthipeptide
Lanthipeptides: C4B68_RS00400_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I +T N D C G+T C Q S A C T +C P
1
Q L I R L T N D G C G S T C Q S A C T-S C P
22
32.7%
NZ_CP054916.1 and 1 other:
NZ_CP054916.1 Lanthipeptides: HUT19_RS32830_lanthipeptide
Lanthipeptides: HUT19_RS32830_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G T C Q S A C+ T C P
1
R L I R M T D D G C G Q T C Q S A C S T T C P
23
32.7%
NZ_CP119145.1 and 1 other:
NZ_CP119145.1 Lanthipeptides: PZB75_RS00285_lanthipeptide
Lanthipeptides: PZB75_RS00285_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G+T C Q S A C+ T C P
1
R L I Q M T D D G C G S T C Q S A C S T T C P
23
32.7%
NZ_JABBWZ010000004.1 and 4 others:
NZ_JABBWZ010000004.1 Lanthipeptides: HHX40_RS10860_lanthipeptide NZ_JABBWZ010000004.1 Lanthipeptides: HHX40_RS10860_lanthipeptide NZ_VYTZ01000008.1 Lanthipeptides: F5972_RS22705_lanthipeptide NZ_VYTZ01000008.1 Lanthipeptides: F5972_RS22705_lanthipeptide
Lanthipeptides: HHX40_RS10860_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G T+C Q S A C T C P
1
K L I R M T D D G C G T S C Q S A C P A T C P
23
32.7%
NZ_WBMT01000015.1 and 1 other:
NZ_WBMT01000015.1 Lanthipeptides: F8566_RS30065_lanthipeptide
Lanthipeptides: F8566_RS30065_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C
47
L I M T+D C G T C Q S A C N T C
1
R L I R M T D D G C G K T C Q S A C P N T C
22
30.6%
NC_007777.1 and 1 other:
NC_007777.1 Lanthipeptides: FRANCCI3_RS10225_lanthipeptide
Lanthipeptides: FRANCCI3_RS10225_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G T T C++A C+ T C P
1
R L I R M T D D G C G T T C E T A C S T T C P
23
30.6%
NZ_AP024745.1 and 1 other:
NZ_AP024745.1 Lanthipeptides: L3i22_RS11845_lanthipeptide
Lanthipeptides: L3i22_RS11845_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T
44
H+I M T D C G T T C Q S A C T
1
H I I K M T G D N C G T T C Q S A C T
19
30.6%
NZ_CM000913.1 and 7 others:
NZ_CM000913.1 Lanthipeptides: SCLAV_RS11700_lanthipeptide NZ_CP016559.1 Lanthipeptides: BB341_RS16135_lanthipeptide NZ_CP016559.1 Lanthipeptides: BB341_RS16135_lanthipeptide NZ_CP042266.1 Lanthipeptides: FQU76_RS24360_lanthipeptide NZ_CP042266.1 Lanthipeptides: FQU76_RS24360_lanthipeptide NZ_CP070379.1 Lanthipeptides: JVE63_RS07215_lanthipeptide NZ_CP070379.1 Lanthipeptides: JVE63_RS07215_lanthipeptide
Lanthipeptides: SCLAV_RS11700_lanthipeptide
26
H L I Y M T N D Q C G T T C Q S A C T N T C P
48
L I M T+D C G T C+S A C+ T C P
1
R L I R M T D D G C G V T C E S A C S T T C P
23

#### MIBiG 4.0 matches for JQS43_RS14385

26.5%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
L D I K F I E A G D A V K H L I Y M T N D Q C G T T-C Q S A C
43
L I I+A G A V ++ C T T C S C
10
L G I V A I Q A G V A V G----V S A A F C P T T K C T S R C
37

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (7):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.14 out of 21.55
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.03 out of 27.04
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.33 out of 32.93
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.36 out of 23.43
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.16 out of 30.98
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.68 out of 27.04
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

JQS43_RS14385 - Class I
  Cleavage pHMM score: -12.30
  RODEO score: 21
  Monoisotopic mass: 5194.3 Da
  Molecular weight: 5197.6 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5215.7 Da N = 1
    5233.7 Da N = 2
    5251.7 Da N = 3
JQS43_RS14385 - Class I
  Cleavage pHMM score: -12.30
  RODEO score: 21
  Monoisotopic mass: 5194.3 Da
  Molecular weight: 5197.6 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5215.7 Da N = 1
    5233.7 Da N = 2
    5251.7 Da N = 3

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (3223044...3248160)
JQS43_RS14390
  RRE type: Lanthipeptide_LanB_RRE
  Location: 138 - 228
  Score: 55.6

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP070499.1 - Region 17 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,649,704 - 3,672,745 nt. (total: 23,042 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidase
JQS43_RS16350: FAD linked oxidase domain protein

smcogs
  SMCOG1138: FAD linked oxidase domain protein

JQS43_RS16365: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Lyases: cyclase
JQS43_RS16355: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.4 |  | 0.49 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0002703.2 |  | 0.49 | ribosomal | archalan α | Halorussus salinus
BGC0000503.5 |  | 0.48 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002346.3 |  | 0.46 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0001210.5 |  | 0.46 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000496.5 |  | 0.45 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001787.3 |  | 0.44 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000527.5 |  | 0.44 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.4 |  | 0.49 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0002703.2 |  | 0.49 | ribosomal | archalan α | Halorussus salinus
BGC0000503.5 |  | 0.48 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002346.3 |  | 0.46 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0001210.5 |  | 0.46 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000496.5 |  | 0.45 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001787.3 |  | 0.44 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000527.5 |  | 0.44 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for JQS43_RS16355

JQS43_RS16375
Leader:
MFTHPEMIFMMATEARHGIVHEVEDHRARRRHRRAGLGTRLRARLRAGGRRATAQSGSGSSLAA
Core:
C V P A G P R A R S
Core with dehydrations:
Cys V P A G P R A R Dha

#### antiSMASH-DB 4.0 matches for JQS43_RS16375

100.0%
NZ_CP070499.1:
Lanthipeptides: JQS43_RS16375_lanthipeptide
1
C V P A G P R A R S
10
C V P A G P R A R S
1
C V P A G P R A R S
10
18.2%
NZ_JAJDST010000044.1:
Lanthipeptides: allorf_014517_014702_lanthipeptide
1
C V P A G P R A R
9
C P A G R+R
3
C A P A G G R S R
11
allorf_3655087_3655302
Leader:
MVLRECLLCVRNAIGRAVGLQDRRADRLTRLGGSSGA
Core:
W F A N M N L V C R R S G S P L N R P S G R R C D S R R Q G G A P S
Core with dehydrations:
W F A N M N L V Cys R R Dha G Dha P L N R P Dha G R R Cys D Dha R R Q G G A P Dha

#### antiSMASH-DB 4.0 matches for allorf_3655087_3655302

100.0%
NZ_CP070499.1:
Lanthipeptides: allorf_3655087_3655302_lanthipeptide
1
W F A N M N L V C R R S G S P L N R P S G R R C D S R R Q G G A P S
34
W F A N M N L V C R R S G S P L N R P S G R R C D S R R Q G G A P S
1
W F A N M N L V C R R S G S P L N R P S G R R C D S R R Q G G A P S
34
47.1%
NZ_CP070499.1:
Lanthipeptides: allorf_3655481_3655615_lanthipeptide
1
W F A N M N L V C R R S G S P L N R P
19
W F A+M N L V C R S G S P L N P
1
W F A S M N L V C R L S G S P L N P P
19
26.5%
NZ_CP007155.1:
Lanthipeptides: allorf_5635321_5635545_lanthipeptide
11
R S G S P L N R P S G R R C D S R R Q G
30
R+G S P S R C D+ +G
3
R T G S P S G A E S I E R C D A H S R G
22
with 5 more sequence matches
25.7%
NZ_CP070499.1:
Lanthipeptides: allorf_3907828_3907980_lanthipeptide
14
S P L N R P S G R R C D S R R Q G G
31
P L R P S G + R G G
6
D P L Q R P S G S P L N P P R A G G
23
25.7%
NZ_CP070499.1:
Lanthipeptides: allorf_3907828_3907980_lanthipeptide
2
F A N M N L V C R R S G S P L N R P
19
A + + R S G S P L N P
2
L A R Y D P L Q R P S G S P L N P P
19
20.6%
NZ_WMBU01000015.1:
Lassopeptides: GG804_RS30050_lassopeptide
8
V C R R S G S P L N R P S
20
V S G+P L R P+
7
V E E F S G A P L Y R P A
19
20.0%
NZ_CP113262.1:
Lanthipeptides: allorf_2442087_2442260_lanthipeptide
10
R R S G S P L N R P S G
21
R R S G L +P S G
8
R R S G G G L G Q P S G
19
11.7%
NZ_CP029711.1 and 1 other:
NZ_CP029711.1 Lanthipeptides: DKM19_RS49800_lanthipeptide
Lanthipeptides: DKM19_RS49800_lanthipeptide
9
C R R S G S P L N R
18
C R S G S +N R
47
C R S S G S V I N R
56
allorf_3655244_3655348
Leader:
MARVLGS
Core:
Y A Q G H Q A A I R K G P L P V A G C H T V G R L V G
Core with dehydrations:
Y A Q G H Q A A I R K G P L P V A G Cys H Dhb V G R L V G

#### antiSMASH-DB 4.0 matches for allorf_3655244_3655348

100.0%
NZ_CP070499.1:
Lanthipeptides: allorf_3655244_3655348_lanthipeptide
1
Y A Q G H Q A A I R K G P L P V A G C H T V G R L V G
27
Y A Q G H Q A A I R K G P L P V A G C H T V G R L V G
1
Y A Q G H Q A A I R K G P L P V A G C H T V G R L V G
27
21.9%
NZ_KZ454939.1:
Lanthipeptides: allorf_0210699_0210824_lanthipeptide
1
Y A Q G H Q A A I R K G P L P V A G
18
++Q H A+R+ P L V
9
F S Q P H L L A L R Q L P L S V E W
26
17.9%
NZ_AP014703.1 and 5 others:
NZ_CP031648.1 Lanthipeptides: allorf_4585502_4585645_lanthipeptide NZ_CP048810.1 Lanthipeptides: allorf_5138083_5138226_lanthipeptide NZ_CP097108.1 Lanthipeptides: M3M50_RS26390_lanthipeptide NZ_JAJQKS010000013.1 Lanthipeptides: LT249_RS28345_lanthipeptide NZ_QGDM01000020.1 Lanthipeptides: allorf_094784_094927_lanthipeptide
Lanthipeptides: allorf_5838294_5838437_lanthipeptide
1
Y A Q G H Q A A I R K G P L P V A G C H T V G
23
Y Q + I L + C T+G
11
Y R Q V N S L G I E S A A L T I V E C G T I G
33
with 1 more sequence matches
16.7%
NZ_FNPT01000012.1:
Lanthipeptides: allorf_041529_041675_lanthipeptide
1
Y A Q G H Q A A I R K G P
13
+A+ +A A+R G P
17
F A R A D R A A L R T G P
29
allorf_3655481_3655615
Leader:
MWTSHSARLGGLGGA
Core:
W F A S M N L V C R L S G S P L N P P R Q L A G L A Q V G
Core with dehydrations:
W F A Dha M N L V Cys R L Dha G Dha P L N P P R Q L A G L A Q V G

#### antiSMASH-DB 4.0 matches for allorf_3655481_3655615

100.0%
NZ_CP070499.1:
Lanthipeptides: allorf_3655481_3655615_lanthipeptide
1
W F A S M N L V C R L S G S P L N P P R Q L A G L A Q V G
29
W F A S M N L V C R L S G S P L N P P R Q L A G L A Q V G
1
W F A S M N L V C R L S G S P L N P P R Q L A G L A Q V G
29
47.1%
NZ_CP070499.1:
Lanthipeptides: allorf_3655087_3655302_lanthipeptide
1
W F A S M N L V C R L S G S P L N P P
19
W F A+M N L V C R S G S P L N P
1
W F A N M N L V C R R S G S P L N R P
19
31.4%
NZ_CP070499.1:
Lanthipeptides: allorf_3907828_3907980_lanthipeptide
2
F A S M N L V C R L S G S P L N P P R
20
A + + R S G S P L N P P R
2
L A R Y D P L Q R P S G S P L N P P R
20
with 2 more sequence matches
27.6%
NZ_CP025227.1:
Lanthipeptides: allorf_0999194_0999376_lanthipeptide
3
A S M N L V C R L S G S P L N P P R
20
+++ L V C L S P P R
8
S T I G L V C T L S W E C T R P P R
25
24.1%
NZ_JACHNX010000043.1:
Lanthipeptides: GGQ89_RS19505_lanthipeptide
1
W F A S M N L V C R L S G S P L N P
18
W S++ C G+P N P
3
W V C S L S G E C N T G G T P C N P
20
allorf_3655601_3655735
Leader:
MTSPHRTLPRSMCKYCCSRRNNCSSFGG
Core:
A V R Q A L L R H H L T C G D A
Core with dehydrations:
A V R Q A L L R H H L Dhb Cys G D A

#### antiSMASH-DB 4.0 matches for allorf_3655601_3655735

100.0%
NZ_CP070499.1:
Lanthipeptides: allorf_3655601_3655735_lanthipeptide
1
A V R Q A L L R H H L T C G D A
16
A V R Q A L L R H H L T C G D A
1
A V R Q A L L R H H L T C G D A
16
23.5%
NZ_JPLW01000002.1:
Lanthipeptides: allorf_1062224_1062367_lanthipeptide
4
Q A L L R H H L T C G
14
Q A L L H T C G
23
Q A L L F H G F T C G
33
16.2%
NZ_LAIJ01000009.1:
Lanthipeptides: allorf_0267158_0267325_lanthipeptide
1
A V R Q A L L R H H L T C
13
+ R+ L H H L C
4
S C R R P D L S H H L A C
16
with 2 more sequence matches
15.0%
NZ_JH600294.1:
Lanthipeptides: allorf_051692_051835_lanthipeptide
6
L L R H H L T C G D
15
L +H H L C D
8
L S K H H L Q C F D
17
11.6%
NZ_CP075170.1 and 1 other:
NZ_CP075170.1 Lanthipeptides: KIK00_RS10035_lanthipeptide
Lanthipeptides: KIK00_RS10035_lanthipeptide
8
R H H L T C G
14
R H+ T C G
13
R H N F T C G
19
allorf_3657166_3657336
Leader:
MQGETMMKFSSLTAAALLTLSLAIAPVIAGG
Core:
V A I S A A T P G F G A E N L S M G G A T C C V D
Core with dehydrations:
V A I Dha A A Dhb P G F G A E N L Dha M G G A Dhb Cys Cys V D

#### antiSMASH-DB 4.0 matches for allorf_3657166_3657336

100.0%
NZ_CP070499.1:
Lanthipeptides: allorf_3657166_3657336_lanthipeptide
1
V A I S A A T P G F G A E N L S M G G A T C C V D
25
V A I S A A T P G F G A E N L S M G G A T C C V D
1
V A I S A A T P G F G A E N L S M G G A T C C V D
25
36.0%
NZ_CP048882.1 and 2 others:
NZ_CP048882.1 Lanthipeptides: G4Z16_RS06545_lanthipeptide NZ_KB905819.1 Lanthipeptides: F603_RS34750_lanthipeptide
Lanthipeptides: G4Z16_RS06545_lanthipeptide
1
V A I S A A T P G F G A E N L S M G G A T C C
23
+I S T P G +E G + C C
2
T S I S Y C T P G C T S E G G G S G C S H C C
24
34.6%
NZ_CP071248.1:
Lanthipeptides: BLI009_RS04985_lanthipeptide
1
V A I S A A T P G F G A E N L S M G G A T C C
23
+I S T P G + N G + C C
4
T S I S L C T P G C T S P N G G S G C S F C C
26
with 3 more sequence matches
32.0%
NZ_FMHI01000015.1 and 2 others:
NZ_JAMTCQ010000009.1 Lanthipeptides: LY41_RS11610_lanthipeptide NZ_LIXJ01000007.1 Lanthipeptides: AMK22_RS13160_lanthipeptide
Lanthipeptides: H180DRAFT_RS21560_lanthipeptide
1
V A I S A A T P G F G A E N L S M G G A T C C
23
++S T P G +E G + C C
2
T S V S Y C T P G C T S E G G G S G C S H C C
24
32.0%
NZ_JAMHJQ010000009.1 and 2 others:
NZ_KN039946.1 Lanthipeptides: FM21_RS35825_lanthipeptide NZ_LIPF01000002.1 Lanthipeptides: AMK11_RS10850_lanthipeptide
Lanthipeptides: M1203_RS22635_lanthipeptide
1
V A I S A A T P G F G A E N L S M G G A T C C
23
++S T P G +E G + C C
2
T S V S W C T P G C T S E G G G S G C S H C C
24
25.8%
NZ_QLMA01000005.1:
Lanthipeptides: CLV59_RS17395_lanthipeptide
9
G F G A E N L S M G G A T C C V D
25
G A N S M G C +D
11
G N A A A N T S M G A P I C S I D
27

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.07 out of 25.31
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47
Confidence: medium
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.81 out of 27.04
Confidence: medium
Additional weak hits (8):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.69 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.70 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.32 out of 29.38
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.27 out of 30.97
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.30 out of 28.14
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.67 out of 27.78
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.55 out of 28.19
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.90 out of 27.04
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

JQS43_RS16375 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 994.5 Da
  Molecular weight: 995.2 Da
  Number of bridges: 1
allorf_3655087_3655302 - Class II
  Cleavage pHMM score: -3.20
  RODEO score: 0
  Monoisotopic mass: 3697.9 Da
  Molecular weight: 3700.1 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3718.2 Da N = 1
    3736.2 Da N = 2
    3754.2 Da N = 3
allorf_3655244_3655348 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 2737.5 Da
  Molecular weight: 2739.2 Da
  Number of bridges: 1
allorf_3655481_3655615 - Class II
  Cleavage pHMM score: -4.20
  RODEO score: 0
  Monoisotopic mass: 3027.6 Da
  Molecular weight: 3029.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3047.5 Da N = 1
    3065.6 Da N = 2
allorf_3655601_3655735 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 1741.9 Da
  Molecular weight: 1743.0 Da
  Number of bridges: 1
allorf_3657166_3657336 - Class II
  Cleavage pHMM score: -2.10
  RODEO score: 0
  Monoisotopic mass: 2269.0 Da
  Molecular weight: 2270.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2288.6 Da N = 1
    2306.6 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
DasR | N-acetylglucosamine dependent repressor
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP070499.1 - Region 18 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,907,047 - 3,930,031 nt. (total: 22,985 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase
JQS43_RS17520: FAD linked oxidase domain protein

smcogs
  SMCOG1138: FAD linked oxidase domain protein

Transferases: methyltransferase
JQS43_RS17505: methyltransferase

smcogs
  SMCOG1089: methyltransferase

JQS43_RS17570: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Lyases: cyclase
JQS43_RS17530: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000528.5 |  | 0.48 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001660.3 |  | 0.43 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0000554.4 |  | 0.42 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001229.4 |  | 0.41 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000527.5 |  | 0.40 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0002698.2 |  | 0.39 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002699.2 |  | 0.38 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000517.4 |  | 0.38 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000528.5 |  | 0.48 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001660.3 |  | 0.43 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0000554.4 |  | 0.42 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001229.4 |  | 0.41 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000527.5 |  | 0.40 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0002698.2 |  | 0.39 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002699.2 |  | 0.38 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000517.4 |  | 0.38 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for JQS43_RS17530

allorf_3907828_3907980
Leader:
MRRALLTRLGGLSGA
Core:
R L A R Y D P L Q R P S G S P L N P P R A G G R A V A L P R L L R L C
Core with dehydrations:
R L A R Y D P L Q R P Dha G Dha P L N P P R A G G R A V A L P R L L R L Cys

#### antiSMASH-DB 4.0 matches for allorf_3907828_3907980

100.0%
NZ_CP070499.1:
Lanthipeptides: allorf_3907828_3907980_lanthipeptide
1
R L A R Y D P L Q R P S G S P L N P P R A G G R A V A L P R L L R L C
35
R L A R Y D P L Q R P S G S P L N P P R A G G R A V A L P R L L R L C
1
R L A R Y D P L Q R P S G S P L N P P R A G G R A V A L P R L L R L C
35
31.4%
NZ_CP070499.1:
Lanthipeptides: allorf_3655481_3655615_lanthipeptide
2
L A R Y D P L Q R P S G S P L N P P R
20
A + + R S G S P L N P P R
2
F A S M N L V C R L S G S P L N P P R
20
25.7%
NZ_CP070499.1:
Lanthipeptides: allorf_3655087_3655302_lanthipeptide
2
L A R Y D P L Q R P S G S P L N P P
19
A + + R S G S P L N P
2
F A N M N L V C R R S G S P L N R P
19
with 4 more sequence matches
25.7%
NZ_CP070499.1:
Lanthipeptides: allorf_3655087_3655302_lanthipeptide
6
D P L Q R P S G S P L N P P R A G G
23
P L R P S G + R G G
14
S P L N R P S G R R C D S R R Q G G
31
22.9%
NZ_CP025701.1:
Lanthipeptides: allorf_017265_017387_lanthipeptide
1
R L A R Y D P L Q R P S
12
R L R Y L Q R S
8
R L V R Y M K L Q R K S
19
22.2%
NZ_BMUQ01000012.1:
Lanthipeptides: allorf_026353_026553_lanthipeptide
9
Q R P S G S P L N P P---R A G G R A V A L P R L
31
++P+ +P L P R A G R A P R L
21
R Q P T T T P L G A P P A R R A W G R A C Q T P R L
46
20.0%
NZ_CP017599.1:
Lanthipeptides: allorf_3521809_3521958_lanthipeptide
8
L Q R P S G S P L N P P
19
L G P L N P P
20
L S H E E G I P L N P P
31

#### MIBiG 4.0 matches for allorf_3907828_3907980

17.1%
BGC0000580.3 (EGD17354.1):
Lasso peptide: xanthomonin II or xanthomonin I
13
G S P L N P P R A G G R A V
26
G P L G G V
1
G G P L A G E E I G G F N V
14
14.3%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
13
G S P L N P P R A G G
23
G P L G G
1
G G P L A G E E M G G
11
allorf_3911208_3911288
Leader:
MGGPLLYRSFVSLPYA
Core:
R I D Q T V T C H Q
Core with dehydrations:
R I D Q Dhb V Dhb Cys H Q

#### antiSMASH-DB 4.0 matches for allorf_3911208_3911288

100.0%
NZ_CP070499.1:
Lanthipeptides: allorf_3911208_3911288_lanthipeptide
1
R I D Q T V T C H Q
10
R I D Q T V T C H Q
1
R I D Q T V T C H Q
10
14.3%
NZ_JAQDYA010000001.1:
Lanthipeptides: allorf_000494_000628_lanthipeptide
2
I D Q T V T C H Q
10
+D Q +T C +
18
V D Q A I T C F K
26
allorf_3911320_3911499
Leader:
MERRSVEDPGVRLEDREWPGR
Core:
V A A G T H I T V S G Y R V R A R L T S A G D T G H V L D D Y C W V G M T D
Core with dehydrations:
V A A G Dhb H I Dhb V Dha G Y R V R A R L Dhb Dha A G D Dhb G H V L D D Y Cys W V G M Dhb D

#### antiSMASH-DB 4.0 matches for allorf_3911320_3911499

100.0%
NZ_CP070499.1:
Lanthipeptides: allorf_3911320_3911499_lanthipeptide
1
V A A G T H I T V S G Y R V R A R L T S A G D T G H V L D D Y C W V G M T D
38
V A A G T H I T V S G Y R V R A R L T S A G D T G H V L D D Y C W V G M T D
1
V A A G T H I T V S G Y R V R A R L T S A G D T G H V L D D Y C W V G M T D
38
18.4%
NZ_AP023392.1 and 4 others:
NZ_CP015557.1 Lanthipeptides: A6M16_RS04830_lanthipeptide NZ_CP065430.1 Lanthipeptides: I5V48_RS05980_lanthipeptide NZ_CP100430.1 Lanthipeptides: NLY76_RS04570_lanthipeptide NZ_JAEUXF010000003.1 Lanthipeptides: JNE40_RS02515_lanthipeptide
Lanthipeptides: H7679_RS04985_lanthipeptide
11
G Y R V R A R L T S A G D T G
25
G+R R+T S G G
1
G F R T A V R M T S Q G R C G
15
allorf_3927305_3927481
Leader:
MSLDDQVLPEDVRRDSQAG
Core:
W P P R P V G E G S P F E P F G W Y A S C L S T S S V S T S S G C G H M P T T
Core with dehydrations:
W P P R P V G E G Dha P F E P F G W Y A Dha Cys L Dha Dhb Dha Dha V Dha Dhb Dha Dha G Cys G H M P Dhb Dhb

#### antiSMASH-DB 4.0 matches for allorf_3927305_3927481

100.0%
NZ_CP070499.1:
Lanthipeptides: allorf_3927305_3927481_lanthipeptide
1
W P P R P V G E G S P F E P F G W Y A S C L S T S S V S T S S G C G H M P T T
39
W P P R P V G E G S P F E P F G W Y A S C L S T S S V S T S S G C G H M P T T
1
W P P R P V G E G S P F E P F G W Y A S C L S T S S V S T S S G C G H M P T T
39
19.0%
NZ_CP041611.1:
Lanthipeptides: allorf_00810301_00810489_lanthipeptide
1
W P P R P V G E G S P F E
13
P R P V G G P E
20
R P T R P V G G G R P H E
32
17.9%
NZ_CP011505.1:
Lanthipeptides: allorf_0567554_0567700_lanthipeptide
6
V G E G S P F E P F G
16
V G E G+P F+ G
18
V G E G T P F D L K G
28
with 2 more sequence matches
17.9%
NZ_DF978419.1:
Lanthipeptides: allorf_0451261_0451407_lanthipeptide
6
V G E G S P F E P F G
16
V G E G+P F+ G
18
V G E G A P F D L K G
28
14.6%
NZ_KB905395.1 and 1 other:
NZ_KB905395.1 Lanthipeptides: allorf_13012_13248_lanthipeptide
Lanthipeptides: allorf_13012_13248_lanthipeptide
22
L S T S S V S T S S G C G H
35
L+ +T S G C G H
20
L A K L G C N T S D G C G H
33

#### MIBiG 4.0 matches for allorf_3927305_3927481

20.5%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
14
P F G W Y A S C L S T S S V S T S S G C
33
P Y A S ++ S + S G C
4
P C T I Y A S V S A S I S A T A S W G C
23
10.3%
BGC0000581.6 (AAD28494.1):
Lasso peptide: microcin J25
32
G C G H M P
37
G G H+P
2
G A G H V P
7

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47
Confidence: medium
Additional weak hits (4):
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.47 out of 20.97
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.42 out of 29.65
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.23 out of 26.06
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.02 out of 28.19
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_3907828_3907980 - Class II
  Cleavage pHMM score: -3.20
  RODEO score: 0
  Monoisotopic mass: 3800.2 Da
  Molecular weight: 3802.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3820.5 Da N = 1
allorf_3911208_3911288 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 1163.6 Da
  Molecular weight: 1164.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1182.3 Da N = 1
allorf_3911320_3911499 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 3923.9 Da
  Molecular weight: 3926.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3944.3 Da N = 1
    3962.4 Da N = 2
    3980.4 Da N = 3
    3998.4 Da N = 4
    4016.4 Da N = 5
    4034.4 Da N = 6
allorf_3927305_3927481 - Class II
  Cleavage pHMM score: -5.40
  RODEO score: 0
  Monoisotopic mass: 3869.8 Da
  Molecular weight: 3872.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3890.2 Da N = 1
    3908.3 Da N = 2
    3926.3 Da N = 3
    3944.3 Da N = 4
    3962.3 Da N = 5
    3980.3 Da N = 6
    3998.4 Da N = 7
    4016.4 Da N = 8
    4034.4 Da N = 9
    4052.4 Da N = 10

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP070499.1 - Region 19 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,428,672 - 4,451,691 nt. (total: 23,020 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
JQS43_RS19925: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

JQS43_RS19960: cytochrome P450

smcogs
  SMCOG1034: cytochrome P450

Transferases: glycosyltransferase
JQS43_RS19975: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Ligases: synthase
JQS43_RS19955: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000664.5 |  | 0.52 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000636.3 |  | 0.51 | terpene | carotenoid | Brevibacterium linens
BGC0000633.3 |  | 0.51 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.51 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.51 | terpene | carotenoid | Myxococcus xanthus
BGC0001456.3 |  | 0.50 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000649.3 |  | 0.50 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000650.3 |  | 0.49 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000645.3 |  | 0.48 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000630.3 |  | 0.47 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000664.5 |  | 0.52 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000636.3 |  | 0.51 | terpene | carotenoid | Brevibacterium linens
BGC0000633.3 |  | 0.51 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.51 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.51 | terpene | carotenoid | Myxococcus xanthus
BGC0001456.3 |  | 0.50 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000649.3 |  | 0.50 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000650.3 |  | 0.49 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000645.3 |  | 0.48 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000630.3 |  | 0.47 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
tetraterpene | C40 carotenoid |  | C40 | unknown | unknown

Genes with terpene domains:
JQS43_RS19930: PT_phytoene_like
Domain 1 (5 - 291): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → squalene
  FPP → PSPP
  FPP → diapophytoene
  GGPP → phytoene
  PSPP → hydroxysqualene

JQS43_RS19940: Lycopene_cycl
Domain 1 (5 - 93): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

JQS43_RS19945: Lycopene_cycl
Domain 1 (6 - 97): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.89 out of 23.43
Confidence: medium
Additional weak hits (4):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.14 out of 23.43
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.42 out of 29.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.23 out of 29.38
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.65 out of 24.78
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
BldD | Development and antibiotic global regulator

NZ_CP070499.1 - Region 20 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,652,958 - 4,734,842 nt. (total: 81,885 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
JQS43_RS20955: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

JQS43_RS20995: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

JQS43_RS21010: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

JQS43_RS21070: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

JQS43_RS21110: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acylase acyltransferase aminotransferase methyltransferase
JQS43_RS20965: O-methyltransferase

smcogs
  SMCOG1042: O-methyltransferase

JQS43_RS20990: O-methyltransferase

smcogs
  SMCOG1042: O-methyltransferase

JQS43_RS21035: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

JQS43_RS21045: aminotransferase

smcogs
  SMCOG1019: aminotransferase

JQS43_RS21060: methyltransferase

smcogs
  SMCOG1089: methyltransferase

JQS43_RS21080: polyketide synthase associated protein papA3

smcogs
  SMCOG1209: polyketide synthase associated protein papA3

JQS43_RS21090: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase
JQS43_RS21015: thioesterase

smcogs
  SMCOG1004: thioesterase

JQS43_RS21065: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase
JQS43_RS21025: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

JQS43_RS21030: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

JQS43_RS21085: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

JQS43_RS21095: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

JQS43_RS21115: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  | 0.85 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  |  | 0.81 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001261.3 |  |  | 0.81 | NRPS | AM-toxin | Alternaria alternata
BGC0001132.4 |  |  | 0.80 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  |  | 0.80 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001050.5 |  |  | 0.79 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0000342.4 |  |  | 0.79 | NRPS | enniatin | Fusarium equiseti
BGC0001128.4 |  |  | 0.78 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  |  | 0.78 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002286.3 |  |  | 0.78 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.73 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.72 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001261.3 |  | 0.72 | NRPS | AM-toxin | Alternaria alternata
BGC0001132.4 |  | 0.72 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001050.5 |  | 0.71 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0000342.4 |  | 0.71 | NRPS | enniatin | Fusarium equiseti
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.71 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 26.57 out of 32.38
Confidence: medium
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 29.28 out of 32.93
Confidence: medium
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 25.70 out of 32.38
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.15 out of 29.72
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.25 out of 20.47
Confidence: medium
Additional weak hits (8):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.65 out of 27.55
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.82 out of 35.63
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.19 out of 18.57
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.29 out of 18.57
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.39 out of 33.14
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.42 out of 29.65
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 26, location 4652957 - 4734842:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Acetyl-CoA - Cys) + (mal - Cys) + (Ala) + (Gly - X) + (Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
JQS43_RS21025: Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (529..935): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDIAFDLSVFDGNTLLSGDISLGGATEGSIWSVA
  Nearest Stachelhaus code(s):
    Cys DLFNLSLIWK (71% 8Å match)
  Stachelhaus code match:
    100% (strong)

JQS43_RS21030: X
AMP-binding (12..404): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    SASAHIGGLWAGFLTSGAALMTYGATEFVGAVAG
  Nearest Stachelhaus code(s):
    2,3-dohHda IGNPTGTIMK (32% 8Å match)
  Stachelhaus code match:
    60% (weak)

JQS43_RS21080: Gly - X
Search NORINE for peptide: strict or relaxed
AMP-binding (484..882): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSMTFDIAGLEGQGWCGGEWNLYGPTETTIWSTA
  Nearest Stachelhaus code(s):
    Gly DILQWGLIWK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1546..1932): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LTRAFDVSVLEFFIGSGGELIGYGPTECTVFSTV
  Nearest Stachelhaus code(s):
    nDodec DVLFIGGVAK (53% 8Å match)
  Stachelhaus code match:
    80% (moderate)

JQS43_RS21085: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (469..876): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    ala (Ala)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSVHFDVSVFEAAQVLAGEVNMYGPTESTVYATY
  Nearest Stachelhaus code(s):
    Ala DVFSVAAVYK (76% 8Å match)
  Stachelhaus code match:
    80% (moderate)

JQS43_RS21090: mal - Cys
Search NORINE for peptide: strict or relaxed
PKS_AT (537..819): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 95.8%
  inactive: 79.2%
  2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 184.4
  inactive: 98.1
  Methoxymalonyl-CoA: 67.0
  Methylmalonyl-CoA: 53.0
  Propionyl-CoA: 36.2
  Ethylmalonyl-CoA: 20.5
  Isobutyryl-CoA: 19.3
  2-Methylbutyryl-CoA: 16.4
  Benzoyl-CoA: 16.0
  CHC-CoA: 15.9
  fatty_acid: 10.7
  Acetyl-CoA: 9.5
  trans-1,2-CPDA: 9.3
  3-Methylbutyryl-CoA: 0.0

AMP-binding (1496..1890): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDVSFDLSVWDGNSLWSGDVSLGGATEAGIWSVF
  Nearest Stachelhaus code(s):
    Cys DLWNLSLIWK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

JQS43_RS21095: Acetyl-CoA - Cys
Search NORINE for peptide: strict or relaxed
CAL_domain (49..492): Acetyl-CoA
minowa: Acetyl-CoA

Prediction, score:
  Acetyl-CoA: 35.9
  NH2: 19.5
  AHBA: 10.6
  shikimic_acid: 0.0
  fatty_acid: 0.0

AMP-binding (1195..1589): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDVSFDLSVWDGNSLWSGDVSLGGATEAGIWSVF
  Nearest Stachelhaus code(s):
    Cys DLWNLSLIWK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

JQS43_RS21115: Phe
Search NORINE for peptide: strict or relaxed
AMP-binding (20..398): Phe
nrpys: Phe

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    HMILHDLGFVCGGALNAAEFNAYGLAEGTVGASA
  Nearest Stachelhaus code(s):
    Phe DLVGMAAVGK (47% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CsoR | Copper-responsive repressor
MexT | Global virulence regulator
NtrC | Nitrogen regulatory protein C
RicR | Copper-responsive regulator
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP070499.1 - Region 21 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,871,698 - 4,896,879 nt. (total: 25,182 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: methyltransferase
JQS43_RS22045: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Lyases: cyclase dehydratase
JQS43_RS22030: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

JQS43_RS22035: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0001289.5 |  | 0.47 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000560.5 |  | 0.45 | ribosomal | subtilomycin | Bacillus subtilis
BGC0002120.3 |  | 0.41 | ribosomal | nocathioamide A | Nocardia terpenica IFM 0706
BGC0001701.4 |  | 0.39 | ribosomal | nisin O | Blautia obeum
BGC0000529.5 |  | 0.39 | ribosomal | microbisporicin A2 | Microbispora corallina
BGC0000783.3 |  | 0.37 | saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0001387.5 |  | 0.36 | other (other) | nucleocidin | Streptomyces calvus
BGC0000103.5 |  | 0.36 | PKS | mycolactone B | Mycobacterium ulcerans Agy99
BGC0000791.3 |  | 0.33 | saccharide | O-antigen | Cronobacter sakazakii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0001289.5 |  | 0.47 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000560.5 |  | 0.45 | ribosomal | subtilomycin | Bacillus subtilis
BGC0002120.3 |  | 0.41 | ribosomal | nocathioamide A | Nocardia terpenica IFM 0706
BGC0001701.4 |  | 0.39 | ribosomal | nisin O | Blautia obeum
BGC0000529.5 |  | 0.39 | ribosomal | microbisporicin A2 | Microbispora corallina
BGC0000783.3 |  | 0.37 | saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0001387.5 |  | 0.36 | other (other) | nucleocidin | Streptomyces calvus
BGC0000103.5 |  | 0.36 | PKS | mycolactone B | Mycobacterium ulcerans Agy99
BGC0000791.3 |  | 0.33 | saccharide | O-antigen | Cronobacter sakazakii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for JQS43_RS22030

JQS43_RS22025
Leader:
MPPVLMLDEADTSTPIPDEEFELDLRVVQTTAAVTSMR
Core:
C D T S D N C G A T C G T S A C N S G S L D P S
Core with dehydrations:
Cys D Dhb Dha D N Cys G A Dhb Cys G Dhb Dha A Cys N Dha G Dha L D P Dha

#### antiSMASH-DB 4.0 matches for JQS43_RS22025

100.0%
NZ_CP070499.1 and 1 other:
NZ_CP070499.1 Lanthipeptides: JQS43_RS22025_lanthipeptide
Lanthipeptides: JQS43_RS22025_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P S
24
C D T S D N C G A T C G T S A C N S G S L D P S
1
C D T S D N C G A T C G T S A C N S G S L D P S
24
62.5%
NZ_CP054916.1 and 1 other:
NZ_CP054916.1 Lanthipeptides: HUT19_RS28935_lanthipeptide
Lanthipeptides: HUT19_RS28935_lanthipeptide
3
T S D N C G A T C--G T S A C N S G S L D P S
24
T S D C G T C G S+C N S D P S
1
T S D G C G N T C A N G A S S C N S Y I E D P S
24
62.5%
NZ_FZNR01000031.1 and 1 other:
NZ_FZNR01000031.1 Lanthipeptides: CHC09_RS41260_lanthipeptide
Lanthipeptides: CHC09_RS41260_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P S
24
C+T D C G T C T S A C N+ S D P+
1
C N T D D G C G D T C N T S A C N T S S Y D P A
24
with 151 more sequence matches
Only the first 10 are displayed here.
62.1%
NZ_FNIX01000023.1 and 3 others:
NZ_FNIX01000023.1 Lanthipeptides: BLQ91_RS35110_lanthipeptide NZ_QQAU01000001.1 Lanthipeptides: DFR72_RS05535_lanthipeptide NZ_QQAU01000001.1 Lanthipeptides: DFR72_RS05535_lanthipeptide
Lanthipeptides: BLQ91_RS35110_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C D T S D C G T C T S A C S G S D P
6
C D T S D G C G D T C N T S A C A S G S N D P
28
61.5%
NZ_JAALAA010000002.1 and 1 other:
NZ_JAALAA010000002.1 Lanthipeptides: G5C66_RS03070_lanthipeptide
Lanthipeptides: G5C66_RS03070_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C T D C G A T C S A C N S S D P
3
C S T G D G C G A T C R P S A C N S V S S D P
25
61.5%
NZ_VLLL01000010.1 and 1 other:
NZ_VLLL01000010.1 Lanthipeptides: LX16_RS23985_lanthipeptide
Lanthipeptides: LX16_RS23985_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C D T S D C G+T C T S A C N S + +P
3
C D T S D G C G S T C A T S A C N S A T N N P
25
60.0%
NZ_CP051627.1:
Lanthipeptides: FOF52_RS15595_lanthipeptide
3
T S D N C G A T C--G T S A C N S G S L D P
23
T S D C G+T C G S A C N S S++P
1
T S D G C G S T C N D G A S A C N S-S I E P
22
60.0%
NZ_KB895858.1 and 1 other:
NZ_KB895858.1 Lanthipeptides: C569_RS0125465_lanthipeptide
Lanthipeptides: C569_RS0125465_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P S
24
C T S D C G++C G T S A C + S D P+
2
C S T S D G C G S S C G T S A C A T S S Y D P A
25
59.3%
NZ_PVZV01000003.1 and 1 other:
NZ_PVZV01000003.1 Lanthipeptides: C2865_RS14135_lanthipeptide
Lanthipeptides: C2865_RS14135_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C T S D C G+T C T S A C N S G +P
4
C S T S D G C G S T C Q T S A C N S G V A N P
26
58.6%
NZ_LN850107.1 and 1 other:
NZ_LN850107.1 Lanthipeptides: BN1701_RS20075_lanthipeptide
Lanthipeptides: BN1701_RS20075_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C D T S D C G T C T S A C++G S D P
6
C D T S D G C G N T C S T S A C S T G S N D P
28
58.3%
NZ_CP022753.1 and 1 other:
NZ_CP022753.1 Lanthipeptides: CDO52_RS26070_lanthipeptide
Lanthipeptides: CDO52_RS26070_lanthipeptide
3
T S D N C G A T C--G T S A C N S G S L D P S
24
T D C G T C G S A C N S D P+
1
T G D G C G N T C Q Q G A S A C N S F V G D P A
24
57.7%
NZ_ATYW01000025.1 and 1 other:
NZ_ATYW01000025.1 Lanthipeptides: YWW_RS32370_lanthipeptide
Lanthipeptides: YWW_RS32370_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C D T S D C G T C T S A C+S + +P
3
C D T S D G C G N T C Q T S A C S S F T N N P
25
57.7%
NZ_SNXZ01000002.1 and 1 other:
NZ_SNXZ01000002.1 Lanthipeptides: EV186_RS12145_lanthipeptide
Lanthipeptides: EV186_RS12145_lanthipeptide
1
C D T S D N C-G A T C G T S A C N S G S L D P
23
C T S D N C G+T C G S A C S P
3
C S T S D N C G G S T C G-S A C T S H V T Q P
25

#### MIBiG 4.0 matches for JQS43_RS22025

15.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
11
C G T S A C N S
18
C T+ C S
17
C P T T K C T S
24
14.8%
BGC0002144.3 (RCCGEPOP_RS37510):
LAP: phazolicin
1
C D T S D N C
7
C D+S C
6
C D S S S R C
12
13.5%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
A T C G T S A C N S
18
A C T+ C S
26
A F C P T T K C T S
35

#### Lanthipeptide(s) for JQS43_RS22040

JQS43_RS22025
Leader:
MPPVLMLDEADTSTPIPDEEFELDLRVVQTTAAVTSMR
Core:
C D T S D N C G A T C G T S A C N S G S L D P S
Core with dehydrations:
Cys D Dhb Dha D N Cys G A Dhb Cys G Dhb Dha A Cys N Dha G Dha L D P Dha

#### antiSMASH-DB 4.0 matches for JQS43_RS22025

100.0%
NZ_CP070499.1 and 1 other:
NZ_CP070499.1 Lanthipeptides: JQS43_RS22025_lanthipeptide
Lanthipeptides: JQS43_RS22025_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P S
24
C D T S D N C G A T C G T S A C N S G S L D P S
1
C D T S D N C G A T C G T S A C N S G S L D P S
24
62.5%
NZ_CP054916.1 and 1 other:
NZ_CP054916.1 Lanthipeptides: HUT19_RS28935_lanthipeptide
Lanthipeptides: HUT19_RS28935_lanthipeptide
3
T S D N C G A T C--G T S A C N S G S L D P S
24
T S D C G T C G S+C N S D P S
1
T S D G C G N T C A N G A S S C N S Y I E D P S
24
62.5%
NZ_FZNR01000031.1 and 1 other:
NZ_FZNR01000031.1 Lanthipeptides: CHC09_RS41260_lanthipeptide
Lanthipeptides: CHC09_RS41260_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P S
24
C+T D C G T C T S A C N+ S D P+
1
C N T D D G C G D T C N T S A C N T S S Y D P A
24
with 151 more sequence matches
Only the first 10 are displayed here.
62.1%
NZ_FNIX01000023.1 and 3 others:
NZ_FNIX01000023.1 Lanthipeptides: BLQ91_RS35110_lanthipeptide NZ_QQAU01000001.1 Lanthipeptides: DFR72_RS05535_lanthipeptide NZ_QQAU01000001.1 Lanthipeptides: DFR72_RS05535_lanthipeptide
Lanthipeptides: BLQ91_RS35110_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C D T S D C G T C T S A C S G S D P
6
C D T S D G C G D T C N T S A C A S G S N D P
28
61.5%
NZ_JAALAA010000002.1 and 1 other:
NZ_JAALAA010000002.1 Lanthipeptides: G5C66_RS03070_lanthipeptide
Lanthipeptides: G5C66_RS03070_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C T D C G A T C S A C N S S D P
3
C S T G D G C G A T C R P S A C N S V S S D P
25
61.5%
NZ_VLLL01000010.1 and 1 other:
NZ_VLLL01000010.1 Lanthipeptides: LX16_RS23985_lanthipeptide
Lanthipeptides: LX16_RS23985_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C D T S D C G+T C T S A C N S + +P
3
C D T S D G C G S T C A T S A C N S A T N N P
25
60.0%
NZ_CP051627.1:
Lanthipeptides: FOF52_RS15595_lanthipeptide
3
T S D N C G A T C--G T S A C N S G S L D P
23
T S D C G+T C G S A C N S S++P
1
T S D G C G S T C N D G A S A C N S-S I E P
22
60.0%
NZ_KB895858.1 and 1 other:
NZ_KB895858.1 Lanthipeptides: C569_RS0125465_lanthipeptide
Lanthipeptides: C569_RS0125465_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P S
24
C T S D C G++C G T S A C + S D P+
2
C S T S D G C G S S C G T S A C A T S S Y D P A
25
59.3%
NZ_PVZV01000003.1 and 1 other:
NZ_PVZV01000003.1 Lanthipeptides: C2865_RS14135_lanthipeptide
Lanthipeptides: C2865_RS14135_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C T S D C G+T C T S A C N S G +P
4
C S T S D G C G S T C Q T S A C N S G V A N P
26
58.6%
NZ_LN850107.1 and 1 other:
NZ_LN850107.1 Lanthipeptides: BN1701_RS20075_lanthipeptide
Lanthipeptides: BN1701_RS20075_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C D T S D C G T C T S A C++G S D P
6
C D T S D G C G N T C S T S A C S T G S N D P
28
58.3%
NZ_CP022753.1 and 1 other:
NZ_CP022753.1 Lanthipeptides: CDO52_RS26070_lanthipeptide
Lanthipeptides: CDO52_RS26070_lanthipeptide
3
T S D N C G A T C--G T S A C N S G S L D P S
24
T D C G T C G S A C N S D P+
1
T G D G C G N T C Q Q G A S A C N S F V G D P A
24
57.7%
NZ_ATYW01000025.1 and 1 other:
NZ_ATYW01000025.1 Lanthipeptides: YWW_RS32370_lanthipeptide
Lanthipeptides: YWW_RS32370_lanthipeptide
1
C D T S D N C G A T C G T S A C N S G S L D P
23
C D T S D C G T C T S A C+S + +P
3
C D T S D G C G N T C Q T S A C S S F T N N P
25
57.7%
NZ_SNXZ01000002.1 and 1 other:
NZ_SNXZ01000002.1 Lanthipeptides: EV186_RS12145_lanthipeptide
Lanthipeptides: EV186_RS12145_lanthipeptide
1
C D T S D N C-G A T C G T S A C N S G S L D P
23
C T S D N C G+T C G S A C S P
3
C S T S D N C G G S T C G-S A C T S H V T Q P
25

#### MIBiG 4.0 matches for JQS43_RS22025

15.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
11
C G T S A C N S
18
C T+ C S
17
C P T T K C T S
24
14.8%
BGC0002144.3 (RCCGEPOP_RS37510):
LAP: phazolicin
1
C D T S D N C
7
C D+S C
6
C D S S S R C
12
13.5%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
A T C G T S A C N S
18
A C T+ C S
26
A F C P T T K C T S
35

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.88 out of 20.47
Confidence: medium
Additional weak hits (2):
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.12 out of 27.78
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.18 out of 30.11
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

JQS43_RS22025 - Class I
  Cleavage pHMM score: -5.40
  RODEO score: 20
  Monoisotopic mass: 2120.8 Da
  Molecular weight: 2122.2 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2140.2 Da N = 1
    2158.2 Da N = 2
    2176.2 Da N = 3
    2194.3 Da N = 4
JQS43_RS22025 - Class I
  Cleavage pHMM score: -5.40
  RODEO score: 20
  Monoisotopic mass: 2120.8 Da
  Molecular weight: 2122.2 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2140.2 Da N = 1
    2158.2 Da N = 2
    2176.2 Da N = 3
    2194.3 Da N = 4

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (4871697...4896879)
JQS43_RS22030
  RRE type: Lanthipeptide_LanB_RRE
  Location: 157 - 251
  Score: 58.0

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
VqsM | Regulator of quorum-sensing signalling systems