LOCUS       NZ_CP070496            21062 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Natronoglycomyces albus strain DSM 106290 chromosome, complete
            genome.
ACCESSION   NZ_CP070496
VERSION     NZ_CP070496.1
KEYWORDS    RefSeq.
SOURCE      Natronoglycomyces albus
  ORGANISM  Natronoglycomyces albus
            Bacteria; Actinomycetota; Actinomycetes; Glycomycetales;
            Glycomycetaceae; Natronoglycomyces.
REFERENCE   1  (bases 1 to 3937850)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Natronoglycomyces albus gen. nov., sp. nov, a haloalkaliphilic
            actinobacterium from a soda solonchak soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3937850)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) Bioinformatics, Leibniz Institute DSMZ,
            Inhoffenstr. 7B, Braunschweig 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 06-MAY-2020
            Assembly Method                   :: HGAP v. 4
            Assembly Name :: 871_Haloglycomyces_alkaliphilus_DSM106290
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 620.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016925535.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 05:55:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,443
            CDSs (total)                      :: 3,382
            Genes (coding)                    :: 3,339
            CDSs (with protein)               :: 3,339
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 43
            CDSs (without protein)            :: 43
            Pseudo Genes (ambiguous residues) :: 0 of 43
            Pseudo Genes (frameshifted)       :: 2 of 43
            Pseudo Genes (incomplete)         :: 40 of 43
            Pseudo Genes (internal stop)      :: 2 of 43
            Pseudo Genes (multiple problems)  :: 1 of 43
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:08:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2023141
            Orig. end                         :: 2044203
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070496.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21062
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="6"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21062
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21062
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11062](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11062
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    1170..1188
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 31.19"
                     /tool="antismash"
     misc_feature    1190..1208
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 24.99"
                     /tool="antismash"
     gene            1470..2519
                     /locus_tag="JQS30_RS08620"
                     /old_locus_tag="JQS30_08610"
     CDS             1470..2519
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018348990.1"
                     /locus_tag="JQS30_RS08620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08610"
                     /product="iron ABC transporter substrate-binding protein"
                     /protein_id="WP_213169887.1"
                     /transl_table=11
                     /translation="MKYPTFKRTLAASAAAAMAISLAACGSDDDNDNGNGDDDTITLYS
                     GRNETLVQPLIDRFTEQTGIEVNVHYYNTAEAASLLLEEGEATNADIFLAQDAGALGAV
                     SKAGLFGEIDSDLTADVDPRFKADDDTWVGLTGRSRVLIYNPDEIGDAELPDSVLDITD
                     GPWAGNVGIAPLNGSFQAFVTALRVAEGDDAAAQWLQDMADTDAPLEENNGAIIDAVVN
                     GDIPAGLVNHYYIWERVVEAGVELDEFEGQLHYFAAGDAGALVNISGVGVLNRASDNDN
                     VRAFVEYLLSEEGQNFFVTETYEYPVVTGIAGPEGQPSLEELNGPDINLNDLDDLETTV
                     QMIQEAGLA"
     gene            2572..4092
                     /locus_tag="JQS30_RS08625"
                     /old_locus_tag="JQS30_08615"
     CDS             2572..4092
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1214:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012181637.1"
                     /locus_tag="JQS30_RS08625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08615"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_343076205.1"
                     /transl_table=11
                     /translation="MAPGWSYLWCIPAVIVAITPLIYLWVRTSELGWETIDGLLRRPRL
                     LEMVGNTLILAATVTVGVLVIGITTAFLVSRTDIRFRALIHILAALPLAAPTYVTAFAW
                     RTTFTGFEGFWPTAIVLTLATFPYVHLPVTAALSRTDPALEDMSRSLGRGPWTTFFAVT
                     IRQIAPAAIAGGLLASLYVLSDFGAVSILKYETFTTAIYSSHRLGFAQDGALLYSSVLA
                     LIALAVLASEWGVSSRGRNVRRTRADGGAVRTARRIRLGWRQVPIWIGIGALTWASLGV
                     MAWSLLKWNIVGVSQAGTAELWSAAATSLGLAAVATVATMLLIVPVGLYVARHRGPLAA
                     VTERLMYIGHALPGIVVGLSLVFMAINVTWLQENMYQTTAWLIVGYAVIFLPLGLGAVK
                     AAAEQAPPRLGEVARSLGRRPSEVFRTVTLPLTAPGIAAGAALVFLTAMKELPATLLLR
                     PAHIDTLATRLWTYTDVSAFSAAAPFAALLVLLSAIPTWLLASRFGRN"
     gene            4092..5126
                     /locus_tag="JQS30_RS08630"
                     /old_locus_tag="JQS30_08620"
     CDS             4092..5126
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018799585.1"
                     /locus_tag="JQS30_RS08630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08620"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_213169889.1"
                     /transl_table=11
                     /translation="MGELQLRKVSKRFGPTRALHEIDLDIPSGHMTAVLGPSGCGKTTL
                     LRCVAGFESLDAGEIWVAGGRIDNLRPERRNIAVVPQEGALFPHLTVARNIAYGLRRFA
                     RKSDRVSEVLELVGLPGYEKRMPHELSGGQQQRVALARAMAPHPALILLDEPFSALDAS
                     LRADLRAQVRQALAADEATAVLVTHDQEEALSVADKVAVMCEGQIQQVDIPTQLYSRPT
                     NEWVARFVGEAVMVPAQVRSGRAETSLGNLPVDVADGTARIMVRPEQIQLDHTAVSGPT
                     ATIAHIEYFGHDTLVDLQLSDGMEVTARILGAAPQVGQEVSVSVSGDVVAYQADKPLIT
                     EKAA"
     gene            complement(5459..7237)
                     /gene="aspS"
                     /locus_tag="JQS30_RS08635"
                     /old_locus_tag="JQS30_08625"
     CDS             complement(5459..7237)
                     /EC_number="6.1.1.12"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004812 - aminoacyl-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /GO_process="GO:0006418 - tRNA aminoacylation for protein
                     translation [Evidence IEA]"
                     /codon_start=1
                     /gene="aspS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012182003.1"
                     /locus_tag="JQS30_RS08635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08625"
                     /product="aspartate--tRNA ligase"
                     /protein_id="WP_213169890.1"
                     /transl_table=11
                     /translation="MYRSHLAGALRSADVDQKVTLAGWVARRRDHGGVEFIDLRDSSGT
                     VQVVFREDAAAEAARDLRNEYCVQIVGTVSGRPEGNENKDIPTGDIEVTAHEVTVLSIS
                     QPLPVPIDDHVEVGEDVRLRHRYLDLRRSGPTKALRLRSEANLIARNLLHDRGFAEIET
                     PTLTRSTPEGARDFLVPVRLQPGTWYALPQSPQLFKQLLMVAGFERYYQIARCYRDEDF
                     RSDRQPEFTQLDIEASFVTQEDILELGEAIVKELWSKLADHDLPTPLPRLTYLDAMNRY
                     GSDKPDLRFGNELVDLTEFLQGTEFRVFAGALAKGGHIGAVVMPGGASQTRKELDGWQE
                     WAKARGAKGLAYVLFDAETGEPKGPVAKNLSAEHLDGLAAAAGAKPGDAVFFAASPDKR
                     EAQELLGAARLEIGQRCDLIDQDAWAFCWVVDFPMFEKTDEGGWTSVHHPFTSPNPEWV
                     EKFTESPDEALTYSYDLVCNGTELGGGSIRIHDGQLQERVFETLGISEEEAREKFGFLL
                     DAFKYGPPPHGGIAFGWDRTCALLAKSDSIRDVIAFPKAGGGSDPLTGAPTPITPAQRK
                     EANVDYVPPKKDDAQA"
     gene            complement(7430..7888)
                     /locus_tag="JQS30_RS08640"
                     /old_locus_tag="JQS30_08630"
     CDS             complement(7430..7888)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037499.4"
                     /locus_tag="JQS30_RS08640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08630"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_213169891.1"
                     /transl_table=11
                     /translation="MSAHTRRIPTQTRRRPVRLSATRLPDRSPLQLLRFSRQELAAAAE
                     HSHPGLRYATAHLAALRAAAAVLVVHSGEDCSPGRVAPLTDTWSLLESVAPELGEWASF
                     FTLTARKRVRAQSGVPGVVTRQEADDLILEVRQFQQVVTRMLGFATTS"
     gene            complement(8294..8836)
                     /locus_tag="JQS30_RS08645"
                     /old_locus_tag="JQS30_08635"
     CDS             complement(8294..8836)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS30_RS08645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS30_08635"
                     /product="hypothetical protein"
                     /protein_id="WP_213169892.1"
                     /transl_table=11
                     /translation="MASLPVPMLAYIGGPALVAILPLVGIVAICDSAFLLLATRSEDIS
                     RRALVFAPLVERLTEAAWLSALWVMGVPGWIVVCSGAACWMYSYTRARARQVGLSHLGM
                     LTLGERAVRTTLAGVGFAAAAVVAIAGGPELATWLPGVVTVTATAWLLVSTLGLLQLVI
                     VVHTALRVNNRNRNGVT"
     misc_feature    8949..8963
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(8974..9906)
                     /gene="metF"
                     /locus_tag="JQS30_RS08650"
                     /old_locus_tag="JQS30_08640"
     CDS             complement(8974..9906)
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014461.1"
                     /locus_tag="JQS30_RS08650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08640"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_213169893.1"
                     /transl_table=11
                     /translation="MTLGTASVLPHNTPAIGDLLRRGPVRYSFEFFPPKTPKGQATLWR
                     SIRRLEALRPDYVSVTYGAGGSTRATTVETTDRIAAETTLLPLAHCTAVDHSVAELRNL
                     IGHFVNVGVRNILAVRGDPPGDPQGRWVQHPEGFLHARELVELIKSSGDFSVGVAAFPE
                     GHPRSPDWDTHVRHFVEKCRSGADFAITQIFFDWQDYVRLRDAVVAAGCDIPIVPGVMP
                     VTNVNQIERFAQLTGMGFPPQLAQRLRREADSPEAVRAIGVEVATELSQKLIAEGAPGI
                     HFITLNHSDSTRKVWANLVSPQAKLVSHL"
     gene            10001..11062
                     /locus_tag="JQS30_RS08655"
                     /old_locus_tag="JQS30_08645"
     CDS             10001..11062
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013020236.1"
                     /locus_tag="JQS30_RS08655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08645"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_213169894.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 9.3e-48, bitscore:
                     160.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAAKLTTRVEAELEVFLARQRDIIVQIDPVLQAYADAVADYVLR
                     GGKRMRPTFAYWGYRGAAGVDCPEVVRGVAALELLQAAALIHDDLIDDSDTRRGQPSIH
                     RRFEALHRDKGWYGQAKHFGSSAAILLGDLCFVWSDEMFTSCGMPMDVLIDARGDFDLM
                     RTQVSAGQYLDVLAGARRDTSVDTAVKVAQFKAAKYTVEQPLLIGASLAGAPMELRRHY
                     SRLGLALGEAFQLRDDVLGVYGDPRQTGKPAGDDLREGKYTYLVAKAFANADSDQKQLL
                     ESRLGDRELDAGAVENLRGVLIDTGALKATEDRIELLAQEAREALLEARSALTADSVPV
                     FEQLLDAAVQRNG"
     gene            11246..11806
                     /locus_tag="JQS30_RS08660"
                     /old_locus_tag="JQS30_08650"
     CDS             11246..11806
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787416.1"
                     /locus_tag="JQS30_RS08660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08650"
                     /product="hypothetical protein"
                     /protein_id="WP_213169895.1"
                     /transl_table=11
                     /translation="MSVFGTLGREITGATRSFIYDVRTSGRFRTVVTLTLAAVASGIVL
                     IAFTMRGLGGIDGPVPDQRDSAHITNGWGQIDSRIVDQQESDEGAPPAPSPDDVSTPAP
                     STPSSADTSSAPSGSSSPPDRISESGTHQPDELIPVPTSSTTPPDDDDDGDDDGDDDDG
                     DDDDEDDGGDDGDDDDDNGGKQD"
     gene            complement(12111..13502)
                     /locus_tag="JQS30_RS08665"
                     /old_locus_tag="JQS30_08655"
     CDS             complement(12111..13502)
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024748.4"
                     /locus_tag="JQS30_RS08665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08655"
                     /product="serine hydrolase"
                     /protein_id="WP_213169896.1"
                     /transl_table=11
                     /translation="MRDHARLARWRMLFAAVLAVTLALTACSGGAESDDGDTGGDEPVA
                     VDIPQTPVGEKLQWYLDKLESLPLEKEEAEQHFAQTFLDQVPVADLNPIMSDMRGTIVT
                     DILDDEPSRLRAEAFHGTGDFHIIIEIDSDSKIETLLFLPPDDMDLPASPTSWDEVDAR
                     LDSIAADSENVGFLAADIDEGECQAVHESSAAIMQPVGSVFKIFVLHAVEQAVAAGDIT
                     WDDHIEITEDIRSLPSGELQDRQAGETVTVYQAAELMISISDNTATDMLIDLLGRDAVE
                     AQVAAIAADADPNLPLIDTRVFFDLKLNDYPAALEAYVNSSSAEKEAFLDSFEALDTPA
                     DADILAWTAEPRAIDTLEWFFSPEDICAAYVAMVGESEEVNSAMSVHDGGLELAAEDWS
                     TLWFKGGNEPGVYAHTHLGIDTDGDGYIVVAMVNNSTALLDEQTLTPELLSIATGSFEM
                     MKSGS"
     gene            complement(13622..14851)
                     /locus_tag="JQS30_RS08670"
                     /old_locus_tag="JQS30_08660"
     CDS             complement(13622..14851)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024760.4"
                     /locus_tag="JQS30_RS08670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08660"
                     /product="PrsW family intramembrane metalloprotease"
                     /protein_id="WP_213169897.1"
                     /transl_table=11
                     /translation="MTVHTERIIVESQGAFVRVRRPAFWLFAGLLVFGLINIGGVLGPS
                     FDQIAGALWVSIAINGALAAAFWWVLARLDLFEREPVAVRMAAFLWGAIASIAVSMMAN
                     NSALIVFAANFGSDWARTWGPAIAGPINEEWFKALGVVLLVLIVREHFHRPMDGLIYGA
                     LIGLGFQVVENVTYAVNFAIINPNSDWAGALSATIIRIAVAGPWSHPLYSAVAGLGIAY
                     FVTQRRRSTAQRAAVAGSLFVLSMAMHALWNLPFAPDLNAGLILVLTYGKGLIILGLFV
                     LLYSAAARREWRWFVDTMSNQPEWVISTDELTSMRSLRSRLQERKAIQKELGKDGRSLL
                     TQLQRELVSLGESLARVQRSSGDPEEAPDVQASKRNLAVIREELARLRAKKNPQPVGQR
                     NTSHEEPNHQ"
     gene            complement(14848..15465)
                     /locus_tag="JQS30_RS08675"
                     /old_locus_tag="JQS30_08665"
     CDS             complement(14848..15465)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS30_RS08675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS30_08665"
                     /product="hypothetical protein"
                     /protein_id="WP_213169898.1"
                     /transl_table=11
                     /translation="MAEATVRLNRFGMEQGRTWPAVAVALAIAIPIMFWTFLERGASQL
                     SEAAPRGSMITVNSYPEDGARLSFAIPSSGWQHDVSVSPAEATIRRGSITLTVQVSAGV
                     NDLERFMERRSDNVVANNTQVIASRPHPYRSHTAQLDGYWSDLVGRSTSGAIVVLRNGS
                     GDDQAARARGAITVIALAPAGRLDEGMTELERLLDSMLLEVK"
     gene            complement(15724..16821)
                     /locus_tag="JQS30_RS08680"
                     /old_locus_tag="JQS30_08670"
     CDS             complement(15724..16821)
                     /EC_number="2.6.1.42"
                     /GO_function="GO:0004084 - branched-chain-amino-acid
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0009081 - branched-chain amino acid
                     metabolic process [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_4 (93-342). E-value: 4.6e-27.
                     Score: 87.2. Matches aSDomain:
                     nrpspksdomains_JQS30_RS08680_Aminotran_4.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018830206.1"
                     /locus_tag="JQS30_RS08680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08670"
                     /product="branched-chain amino acid aminotransferase"
                     /protein_id="WP_213169899.1"
                     /transl_table=11
                     /translation="MTIEALPTFTQLPHPHATDAAKRAELLTNPGFGRLFTDHMVTIKY
                     HVDKGWYEPQVEPYGPITLDPAASVLHYAQEIFEGMKAYRYDDGGVGLFRPEANARRFN
                     ASAKRMSMPQLPVDLFMESIKQLVSVDKDWVPTQAEASLYLRPFMFATEAFLGVRPAKE
                     FLYTLIASPAGAYFASGPKPVTIWVSREYTRAAPGGTGTAKCGGNYAASLAAQAEAIEN
                     GCDQVVFLDAVERKYVDELGGMNLFFVYENDQVIYTPKLGTILPGITRDAIISLAGEAG
                     WEVREVDYSLDRWREDANSGALTEVFACGTAAVITPVGTVREADGDFTISKAQAGKLTM
                     QLRQTLLDLQHGRAEDRHGWVQRLL"
     aSDomain        complement(15796..16542)
                     /aSDomain="Aminotran_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQS30_RS08680_Aminotran_4.1"
                     /evalue="4.60E-27"
                     /label="JQS30_RS08680_Aminotran_4.1"
                     /locus_tag="JQS30_RS08680"
                     /protein_end="342"
                     /protein_start="93"
                     /score="87.2"
                     /tool="antismash"
                     /translation="FRPEANARRFNASAKRMSMPQLPVDLFMESIKQLVSVDKDWVPTQ
                     AEASLYLRPFMFATEAFLGVRPAKEFLYTLIASPAGAYFASGPKPVTIWVSREYTRAAP
                     GGTGTAKCGGNYAASLAAQAEAIENGCDQVVFLDAVERKYVDELGGMNLFFVYENDQVI
                     YTPKLGTILPGITRDAIISLAGEAGWEVREVDYSLDRWREDANSGALTEVFACGTAAVI
                     TPVGTVREADGDFTISKAQAGKLTMQL"
     gene            complement(17127..18164)
                     /locus_tag="JQS30_RS08685"
                     /old_locus_tag="JQS30_08675"
     CDS             complement(17127..18164)
                     /EC_number="1.1.1.85"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0003862 - 3-isopropylmalate dehydrogenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0009098 - leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013019509.1"
                     /locus_tag="JQS30_RS08685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08675"
                     /product="3-isopropylmalate dehydrogenase"
                     /protein_id="WP_213169900.1"
                     /transl_table=11
                     /translation="MHNIAVIPGDGIGREVISEAQKVLEVALPNHTATEFDLGARCYAR
                     TGEALPASVQAELADHDAILLGAVGDPSVGPGILERGLLLKLRFDFDQYVNLRPARLWP
                     GVNSPLAEVKSGEIDFLVVREGTEGLYAGAGGVVQRGTSAEVATEESLNTRYGVERVVR
                     HACQLAALRERKRLTLVHKTNVLVNAGSLWQRTFDEVVRDFPELTTDYQHVDAASMFMV
                     DRPETYDVIVTDNLFGDILTDIAAAITGGIGLAASGCINPDQSYPSMFEPVHGSAPDIA
                     GQGIADPIAAIISAAMLLDHLGRAEDADIVRRACAAELADRKPGQPVRTAEVGDRVAAA
                     VEKRM"
     gene            complement(18465..19373)
                     /locus_tag="JQS30_RS08690"
                     /old_locus_tag="JQS30_08680"
     CDS             complement(18465..19373)
                     /GO_process="GO:0043248 - proteasome assembly [Evidence
                     IEA]"
                     /GO_process="GO:0051131 - chaperone-mediated protein
                     complex assembly [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028437.1"
                     /locus_tag="JQS30_RS08690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS30_08680"
                     /product="PAC2 family protein"
                     /protein_id="WP_246497830.1"
                     /transl_table=11
                     /translation="MSIDRWSLCDILSDEPEARGAVMLLHLEGFMDAGSAGKGVVEALL
                     EENDHQPVASFDVDQLMDYRSRRPNLTFSIDHWSDFDAPQLVVYLLRDAQGQPYLLLSG
                     PEPDFAWERFVDAVEDLVDYFAISLVVGLQGIPMGVPHTRPLGLTVHATRPELVFDNRP
                     VFSEMQVPGHAAGLLQFRLGQSGRDAIGLAAHVPHYLTQMSYPAASLRLIEAVAKATDL
                     ELPTSSLEMSREEVAEEIAQQVAENSEVEEIITTLEEQYDSFTEQAESDEMLADGRVPT
                     AEELGAAFEHFLANQDRPDKE"
     misc_feature    complement(19419..19430)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.2"
                     /tool="antismash"
     misc_feature    19461..19476
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.58"
                     /tool="antismash"
     misc_feature    20188..20203
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.12"
                     /tool="antismash"
     misc_feature    complement(21043..21057)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
ORIGIN
        1 gtcgtttgca gcagcgtcgg atcggccatg cccacgtcct cagaggcgaa gatgaccaaa
       61 cgccgagcga tgaagcgtgg gtcctcaccg gccacaatca tgcgagccag ccaatgcaaa
      121 gccgcgtcca cgtccgagcc gcgcaaactc ttaatgaacg ccgaggcgat gtcgtagtgg
      181 ccatcaccgg aacgatcgta acgagccgcg gccatgtcga tggccttgga aaccgactcg
      241 acatcgatga cggtttcacc acgcgaaaga accgaagccg ccgctgcctc cagtgccgta
      301 agcgacttgc gcgcgtcccc agcggcgagc cgaaccaagt gctcccgggc ctcttcggtg
      361 acagagaccg cctgcgacaa gccgcgttga tcggttagcg cccgatcgat cagcactccc
      421 aggtcctcgt cggtgaggtc gtgcagagtt aggattatgc acctactgac cagcggagac
      481 acgactgaaa aatacggatt ctcggtcgtg gcggccaaga gggtgatcgt acggtcctca
      541 accgccgaca acaatgaatc ctgctgggtc ttgttaaagc ggtgcacctc gtcgatgaag
      601 agaacagttt gcgcgcctcc ggtacgccga atctggcgag cgtgatcgat ctcggcccgc
      661 acctgtttca cccctgagtc cagggccgac agcgaccgaa accggcgatc gatggccccg
      721 gcgaccaagt gagcgatcgt ggtctttccg ctaccgggcg gcccccagag gatgactgac
      781 attggttgac cgccatgcac cagttgccgc aacggcgctc cggaggcaag taggtgctgt
      841 tggccaacca gctcctccag gttcgacgga cgcatccgca ccgccagcgg ggcatcggtg
      901 ggaattgccg aggccgcagt atcgtcgtca tgactgtcga atagtccggg agtgtccatc
      961 tacgccagaa tagtgcactc ctaagacagc acggagaatc agccactgtt ggaaatggct
     1021 agcgcccgag gtctcaccga actcacatcg ctttgtcatc gcgccgaacc gagccgaatt
     1081 cttctcactt atcaacaatt cggtcacctt cgaacccgtt cctgcggcac caatcacaga
     1141 ctgagggtgg cgacgcaatc cgaaataagc taggttaggc ttgccttaat cagctaaggc
     1201 ttacttaaca gcactaaacg actagtaaac gacaaacaaa acgcacgtga catttggcgt
     1261 ttattggtcg acaagaatat agacgacgaa gccggaccga accacatcgt gacatacgga
     1321 tcagcccggc ttcaacggcc agtgacggtg cgcaacacct cagaccacct caacgacact
     1381 cgcctcgtac gcgcgtgtcg ccccaatgcg ccggtggcac accgatcgcc cgctcacagg
     1441 cccttcatat cgccctctgg aaggaaccaa tgaagtaccc gactttcaag cggacactgg
     1501 cggcctcagc cgccgccgcg atggccatca gtctggccgc ttgcggcagc gacgacgaca
     1561 atgacaatgg taacggcgac gacgacacga tcacgctcta ctccggtcgc aacgaaaccc
     1621 tcgtccagcc gctgatcgac cgcttcaccg aacagaccgg catcgaggta aacgtccact
     1681 actacaacac cgccgaggcc gccagccttc tgctcgaaga aggcgaggca accaacgcgg
     1741 acatcttcct ggcccaagac gccggtgcgc tgggcgccgt ctccaaagct ggactcttcg
     1801 gcgagatcga cagcgacctc accgctgacg tcgacccccg attcaaagcc gacgacgaca
     1861 cctgggttgg cctgaccggt cgctcccgcg tcctcatcta caaccccgac gagatcggcg
     1921 acgccgaact tcccgactcg gtactggaca tcaccgacgg accatgggct ggaaatgtcg
     1981 gcatcgcgcc gctcaacggt tccttccaag ctttcgtcac cgctctccga gtggccgagg
     2041 gcgacgacgc cgccgcccag tggctccaag acatggccga caccgacgcg cccttggaag
     2101 agaacaacgg ggcgatcatc gacgcggttg tcaacggcga catcccggct ggactagtca
     2161 accactacta catctgggag cgagtcgtcg aagccggagt cgagctcgac gagttcgaag
     2221 gccagctgca ctacttcgcc gccggagacg cgggcgcgct agtgaacatc tctggggtgg
     2281 gcgtgctgaa ccgcgcctcc gacaacgaca acgtgcgggc cttcgtcgag tacttgctca
     2341 gcgaggaagg acagaacttc ttcgtcaccg agacttacga gtaccccgtc gtgaccggaa
     2401 tcgccggccc cgaaggccag ccgtcgctgg aggagctcaa cggaccagac atcaacctga
     2461 acgatctcga tgacctggag accaccgttc agatgattca ggaagcagga ctggcctagc
     2521 ttgccacttc gatcaactct gttgcggcct ggggccaccc gaacacaacg ggtggcccca
     2581 ggctggtcgt acttgtggtg cataccggcc gtcatcgttg cgattacccc tctgatctac
     2641 ctgtgggtcc gtacctctga gttgggctgg gagaccatcg atggtctgct gcgcagacca
     2701 cggcttctag aaatggtcgg caacacgctc atattggcgg caacggtgac cgtcggagtc
     2761 ctggtcatcg gtattacgac ggcgtttttg gtgtcgcgca ccgatattcg attccgcgcg
     2821 ctcattcaca tcctggccgc gctgccgctt gccgccccca cttacgtgac cgcctttgcc
     2881 tggcggacca cgttcaccgg attcgaagga ttctggccca cggccatcgt tctcaccctc
     2941 gcgaccttcc cctacgttca cctcccggtc acagcggcgc tctcacgcac cgaccccgcc
     3001 ctggaggaca tgtcgcgttc gctggggcgc ggcccctgga cgacattttt cgcggtgacg
     3061 atccgccaaa tcgcaccggc ggcaatcgcg ggaggcctgc tcgcctcgct gtacgtactc
     3121 tccgacttcg gtgccgtctc catcctcaaa tacgaaacgt tcaccaccgc gatctattcc
     3181 tcccaccggc tcggattcgc ccaagacgga gcactcctct actccagcgt cctcgccctg
     3241 atcgccctgg cggtgctcgc cagcgaatgg ggagtcagct cccgggggcg taacgtccga
     3301 cgcacccgcg ctgacggtgg agcagtccgc acagcccgcc gcattcggct cggatggcgg
     3361 caagtgccca tttggatcgg cattggagca ctcacctggg cctcactggg ggtcatggca
     3421 tggagcctcc tgaaatggaa catcgtaggc gtctcccagg cgggcaccgc cgagttgtgg
     3481 tcagccgcgg ccacctcgct gggcttggcg gcggtggcca cagtcgcgac catgttgctg
     3541 atcgttcccg tcggcctcta cgtggcacgg catcgagggc cgttggcggc ggtcaccgaa
     3601 cgactgatgt acatcgggca cgcgttgcca ggaatcgtcg ttggcctatc gctagtcttt
     3661 atggccatca acgtcacgtg gcttcaagag aacatgtatc agaccaccgc ctggctgatc
     3721 gtcggttatg ccgtgatctt cctgccattg gggctcgggg ccgtcaaggc cgcagccgaa
     3781 caggccccgc ctcgtttggg tgaagtggct cggtcgttgg gccggcggcc ctccgaagtg
     3841 ttcaggacgg tcacgctgcc gctaacggcg ccgggcatcg ccgctggggc cgcactggta
     3901 ttcctgacag cgatgaaaga actaccggcg acgttgctct tgcgtcccgc gcacatcgac
     3961 acattggcca cccgcctatg gacgtacacc gatgtgtcgg cattctcggc cgcggctcca
     4021 ttcgcggcgc tattggtctt gttgtcggcc attcctacct ggctgctggc cagtcgattt
     4081 gggaggaact gatgggtgaa ctgcaactgc ggaaagtctc gaagagattc ggtcccaccc
     4141 gcgcattgca cgaaatcgac ctcgacattc cctcaggcca catgacggcc gtgctgggac
     4201 cgtcgggctg tgggaagacg acactgctgc gatgtgtggc gggttttgag tctctcgacg
     4261 ccggtgaaat atgggtcgcc ggaggccgca tcgacaatct gcgtcccgaa cgccgcaaca
     4321 tcgcggtcgt accccaagag ggtgccctct tcccccatct gaccgtcgca cgcaacatcg
     4381 cctatggact acggcgcttc gcgcgtaagt cagatcgagt cagcgaagtg ttggaactag
     4441 ttggtttgcc cggctacgaa aaacggatgc cacacgaact gtcaggtggc caacagcaac
     4501 gggtggcatt ggcccgcgcc atggctccgc atccggcact gatattgctc gacgagccgt
     4561 tcagtgcctt ggacgcaagc ttgcgggcgg acctgcgagc ccaagtgcgc caggccttgg
     4621 ccgccgacga ggctacggcg gtgctggtca ctcatgacca agaggaagca ctgagtgtgg
     4681 ccgacaaagt agcggtgatg tgcgagggcc agatccaaca ggttgacatc ccaacgcagc
     4741 tttacagccg tcccaccaac gagtgggtgg cgcggttcgt gggagaggca gtcatggttc
     4801 cagctcaagt tcgttcggga cgggccgaaa cgtcgctggg gaacctcccg gtcgacgttg
     4861 ccgacggtac cgcgcgaata atggtccgcc ccgagcagat ccaactggac catacggccg
     4921 tcagtgggcc gacggcgaca atcgcccaca tcgaatactt cggccatgac acattggtag
     4981 acctccagtt gagtgatggc atggaggtca ccgcccgtat tctcggcgcg gcgcctcagg
     5041 tgggccagga agtctcggta agcgtcagcg gtgacgtggt ggcctatcaa gccgacaagc
     5101 ccctcatcac tgagaaagct gcctaagcgg atagtgcggg gtttcatgga acctcgtaca
     5161 tatcccccaa cctgccgagg atgtcggtcc acatgggccc acctgtggcc ctaaggcgga
     5221 acccgtaact cagagacgcc ccaagcgcta ccgctcgcct gtaaaatcgg cccacctggt
     5281 atgcccatcg gtcaccgcaa ccgtacgcaa cggcctctat ggtctcgcac gtatttcgcg
     5341 ccaagcggcg tcgcgttgag aactccccca agcccgaatt gccgcagtat tcgcagcacg
     5401 agtcgggggc acagctgtga gtgctgcgcc cccgaacaac gggcctaagt tcgcgacgct
     5461 atgcctgggc gtcgtccttc ttcggcggca catagtcaac gttcgcttcc ttacgctgtg
     5521 ccggggtgat cggagtcggc gcaccagtca acgggtcgga accgccgcca gccttcggga
     5581 aggcaatgac gtcacgaatc gagtcggact tggccagcaa agcacaggtc cggtcccagc
     5641 cgaacgcaat gccaccgtgc ggcggcggtc cgtacttgaa ggcgtccaag aggaaaccaa
     5701 acttctcccg cgcttcctct tcgctgatac cgagggtttc gaagaccctc tcttgtagct
     5761 ggccatcgtg gatacggatc gaccctccac ccagctccgt accgttgcag acgaggtcgt
     5821 aagaatacgt cagcgcttcg tctggggact cggtgaactt ctcgacccac tctgggttcg
     5881 gtgacgtgaa cgggtgatgg accgaagtcc aaccaccctc gtcggtcttt tcaaacatgg
     5941 ggaagtcgac aacccagcag aaggcccagg cgtcttggtc aatgaggtcg caccgttgac
     6001 cgatctctag acgcgccgcg ccaagcagct cctgcgcctc ccgcttgtcc ggagaagccg
     6061 cgaagaagac cgcgtcgcct ggcttggcac cagcggcggc ggcgaggccg tccaggtgct
     6121 ctgcggacag gttcttggca accggaccct tcggctcgcc tgtctccgcg tcgaagagga
     6181 cgtaggccag gccctttgct ccacgcgcct tggcccactc ctgccagccg tccagctcct
     6241 tgcgcgtttg agaggcacca cctggcatga ccacggcccc gatgtggccg cccttggcca
     6301 gcgctcccgc gaacacacgg aactcggtgc cttgcaggaa ctcggtgagg tcgaccagct
     6361 cgttgccgaa acgcaggtcc ggcttgtccg agccatagcg gttcatcgcg tccaagtaag
     6421 tcagacgcgg caatggagtc ggaaggtcat ggtcggccag tttgctccac agttccttga
     6481 cgatcgcctc tcccagttcg aggatgtcct cctgggtgac aaacgaggcc tcgatgtcca
     6541 actgagtgaa ttcaggctgg cgatccgaac ggaagtcttc gtcgcggtag cagcgcgcga
     6601 tctggtagta gcgttcaaag cccgcgacca taagcagttg cttgaacagc tgtggcgact
     6661 gtggcagtgc gtaccacgtt cccggctgga gacgcacggg gacgaggaag tcgcgcgcgc
     6721 cctccggggt ggaacgagtc agcgtcggcg tctcgatctc ggcgaaaccc cggtcgtgca
     6781 gcaggttgcg cgcgatcaga ttggcctcgg aacgcaaacg cagggccttc gtgggtcctg
     6841 aacgccgaag gtcgagatag cggtgacgca ggcgcacatc ttcaccgacc tcgacatggt
     6901 cgtcaatggg caccggcagc ggttgcgaga tcgacaaaac ggtgacctca tgcgctgtca
     6961 cctcgatgtc gccagtggga atgtctttgt tttcgttgcc ctccggtcgg ccggagacgg
     7021 taccgacgat ttgcacacag tattcgttgc gcaggtcgcg agccgcttcg gcggcggcgt
     7081 cctcccggaa caccacctgc accgtgccag aagaatctcg caggtcgatg aactccaccc
     7141 cgccgtgatc gcgccgacga gccacccatc cggcaagggt gactttttgg tcaacgtcag
     7201 cggagcgcaa tgctccggca agatgagaac gatacacgag ttcctgctcc ttggcagttg
     7261 gagaaaattg acctttgtcg cagcgtccgc cggtacacga ccggtttccc gacgctgacc
     7321 aacagtgtgg caaacgtgcc ccacaggccg caattctata atgcggcgtt gccgatcaat
     7381 cacaccgcca agcgccacgt tccctatgcc atcgataacc caagacgctt caggaagtgg
     7441 tggcgaatcc gagcatccgc gtcaccacct gttgaaactg gcgaacctcc aggatgagat
     7501 cgtccgcttc ttgtcgagta accacaccgg ggacgccgga ctgggctcgg actcgtttac
     7561 gagcggtcaa ggtgaagaag ctggcccact cccccagctc aggggcgact gattccagta
     7621 gcgaccacgt gtcggtgagc ggggcaacac ggccgggcga acaatcctct cccgagtgca
     7681 ccactagcac ggccgcagca gcgcgaagcg ccgccaagtg agccgtcgcg tatcgcaacc
     7741 ccgggtgaga atgttctgcg gcggcggcaa gttcctggcg ggagaaccgc agcaactgca
     7801 acggtgaacg gtcgggaagt cgagtggccg acaaccgcac agggcgacgg cgcgtctgag
     7861 tcggtatccg acgagtatgt gctgacatga tgtgttgtcc ttccccgccg gatggtgctc
     7921 cggcgactga gcaagaaccc gtcaacagcc aataaaccag gagggtatga catttcttcg
     7981 tgcatacgta ctgaccaggc gtttcggcag gtgacgtcgc ggtcgcgcgc ggtagccaat
     8041 gcggcgcggc gaccacctcg ttggaagatg ccgcacggtc gagtcgagga atcggttggc
     8101 cgtcggcttg ggtcgggata ggaacacttt tcgagcccac gcgtcgctaa gagagctcca
     8161 tcagctcagc gaacctgatc agcctgccct ccttagccgc ctcaagttgt ccaagcggcg
     8221 gagaaggtcg gtggccagag gttgcgcgga accaacatac gcgaagctac gtgggcggct
     8281 tcatctcaca tgtctaggtc actccattgc ggttgcggtt gttcacccgc aacgcagtgt
     8341 gcaccacaat caccagttgg agcaacccca aggttgacac gagcaaccac gcggtcgccg
     8401 tcaccgtcac gacgccgggc aaccaggttg ccagctcagg gcccccagca atggccacca
     8461 cagccgcagc cgcgaaacca actccggcca aggtggtccg caccgcccgt tcgccaagtg
     8521 tgagcatgcc taggtgactc aggccaacct gacgggcacg ggctcgcgta taggagtaca
     8581 tccagcacgc agcgcccgaa cacacaacga tccagccggg aacgcccatg acccatagag
     8641 cggacaacca cgcggcctcg gtgagacgtt cgaccaaggg ggcgaagacc aacgcccgcc
     8701 ggctgatgtc ctcggaacga gtggccagga gaagaaaggc agagtcgcaa atggcgacaa
     8761 tgcccaccaa aggaaggata gccacgagtg cgggcccgcc aatataggcg agcatgggca
     8821 cgggcagtga ggccactagc gatacccaga ccacagtgcc tggttcaacg cccgtggaca
     8881 gtatcgcccg gcccatcaat gaatctgctg gcactcgcga gcgcatggca tatgttttag
     8941 cagaagccat cgccggtgtc gatacagcac tggtcacaag tgactcacca acttcgcttg
     9001 cggtgaaacg agattcgccc aaactttgcg ggtggagtcg gagtgattca gggtgatgaa
     9061 gtgaatccct ggggcacctt ccgcgataag tttctggctc aactctgttg ctacctctac
     9121 acctatcgca cgtaccgcct cagggctgtc ggcttcccga cgcagtcgct gtgccagttg
     9181 cggcggaaag cccattccgg tgagttgagc gaaacgttcg atctgattca cattcgttac
     9241 cggcataaca ccgggcacga tgggaatgtc gcagccggcg gccaccactg cgtcgcgcag
     9301 gcgcacgtag tcttgccaat cgaaaaagat ctgcgtgatc gcgaagtctg cccccgagcg
     9361 gcatttttcc acgaagtggc gcacatgcgt gtcccaatcc gggcttcgcg ggtgcccttc
     9421 tgggaacgcg gccacgccca cggagaaatc acccgaggac ttgatcaact cgaccagctc
     9481 gcgggcatgg aggaagccct ccgggtgctg tacccaccga ccctgcgggt cgccaggggg
     9541 gtctccccgc actgccagga tgttgcgcac cccgacgttg acaaagtggc caataaggtt
     9601 acgcagctcg gcgaccgagt gatcaacggc ggtgcaatgc gccagcggta gcagcgtcgt
     9661 ctcggctgcg attcgatccg tcgtctccac cgttgtggcc cgagtcgaac ccccagcccc
     9721 ataggtgacc gagacatagt cggggcgcaa tgcctccaaa cggcgaatac ttcgccacag
     9781 cgtcgcctgt ccctttggcg tcttcggcgg gaagaattcg aacgaatagc gcaccgggcc
     9841 acgccgcagc aggtcaccga tcgccggggt gttgtgggga aggaccgaag cggtaccgag
     9901 tgtcatggat tcaccttacg aaatgagacg aaagtggtct gagtggcggg aatacccacc
     9961 cattacgtga gacgacgact caaggcttag ggtcgagtct gtggaagctg ccaaactaac
    10021 aacccgcgtc gaagccgagc tcgaggtatt tctcgcccgt cagcgggaca tcatcgtcca
    10081 aatcgacccg gtcctccaag cttacgccga cgcggtggca gattacgtcc tgcgcggcgg
    10141 caaaagaatg cgcccaacat tcgcctactg gggatatcgc ggggcggcag gtgtcgattg
    10201 ccctgaggtc gtacgcgggg ttgcggcatt ggagctgcta caggcggccg cgctgattca
    10261 cgatgacctc attgacgact ccgacacgcg ccgcggccag ccgtcgattc accggcgttt
    10321 cgaagcactg caccgggaca aaggctggta cggccaggca aagcactttg ggtcctcggc
    10381 cgccatactg cttggcgatt tgtgcttcgt gtggtcggac gaaatgttca ctagctgtgg
    10441 aatgcccatg gacgtactca tcgacgccag aggcgacttc gacctcatgc ggactcaagt
    10501 atcggctggg caatacctag atgttctggc cggggcgcgc cgcgacacca gcgtcgacac
    10561 ggcggtgaaa gtggcacagt tcaaagccgc gaagtacacc gtggagcaac cgctgctcat
    10621 cggggcatcg ctcgctggcg cgcctatgga gttgcgtcgt cactacagcc gcctcggcct
    10681 tgcgctggga gaggcgttcc agctgcgtga cgacgtactg ggcgtctacg gtgacccacg
    10741 gcaaaccggt aaaccggcag gcgacgatct gcgagaggga aagtacacct atctggtcgc
    10801 caaagcgttc gccaatgccg actccgacca aaaacagctc ttggagtcgc ggttgggtga
    10861 tcgtgaactc gatgccggag ccgtcgagaa tctgcgcgga gtcctcattg acaccggcgc
    10921 tctgaaagcc actgaagacc gcatcgagct actagcgcag gaggctcgtg aagccctgct
    10981 cgaggcacgt tccgccctca ccgccgattc cgtcccagtc ttcgagcagc tgctcgatgc
    11041 ggctgtgcaa cgcaacgggt gacaggaggg ccgcagccca agtgaggacg ctccccggcc
    11101 ggtacttctt atgccccaat gcaccttttc ggatatttta tccgtcacct gtgtgggttc
    11161 atccagtgag cgcccagtgt ctccacgtca ccgttttcgt tgatccctgc ggtgggagta
    11221 catcgatcgc cgctgggagg cacccatgtc agttttcggc acgttgggcc gggagatcac
    11281 cggagccaca cggtcgttca tctacgacgt ccgtacatca gggcgattcc gaactgtcgt
    11341 caccttgact ttggccgccg tggcctctgg cattgtcctg atcgccttta cgatgcgtgg
    11401 attgggcggg atcgacggcc cagtgccgga ccaacgggac agcgcccaca tcaccaacgg
    11461 ctggggacag atcgactcac gcatcgtgga tcaacaagaa agtgacgaag gcgcaccgcc
    11521 cgcaccttct ccagacgatg tctccactcc tgcgccgtct actccgtcct cggcggatac
    11581 ctcgtcagcc cccagtggtt cctcgtctcc gcccgaccgc atctctgagt ccggtacgca
    11641 tcagcccgat gaactgatac ccgttccgac cagttcgacg acaccgccgg acgatgacga
    11701 cgatggggac gatgacgggg acgacgatga cggggacgat gatgatgagg atgatggcgg
    11761 agacgatggg gacgacgacg atgacaacgg cggcaagcag gattagcctg ccttcggtcg
    11821 gctgcggaga catcgtcatt gatcaggggt aggcctacta tccacgaatt gtttagcgtg
    11881 gccccaacgg ccaatggccc cggcaaagga gcccgcgacc atccatggga cggcagcttc
    11941 atcgaatccg ggctcaccgc tgagttggga aattgacctg tgggtgcgcc ggtggtgccg
    12001 tgacctagcc acggcaccac cggcgcaccc tcgaccattg ctccgtagct tgggcgataa
    12061 cccaaagttc ccacaggcac ttctcgtcgt cccgttcttc acactcgggg tcaagaaccg
    12121 cttttcatca tttcgaacga gcccgttgcg atcgacagca actccggggt caaagtctgc
    12181 tcatccaaca gcgcggtgga attgttaacc atggccacga cgatgtaccc gtcgccatcg
    12241 gtgtcgatac caaggtgagt gtgcgcgtag acgccgggct cattaccccc tttgaaccac
    12301 agtgtcgacc agtcctccgc agccagctcc aggcctccat catgaaccga catcgccgag
    12361 ttaacctcct cgctttcccc aaccatcgcc acgtaggcgg cgcaaatgtc ctcaggggag
    12421 aaaaaccatt ccagggtgtc aatagcgcgg ggttcggcgg tccaggcaag aatgtccgcg
    12481 tcagctggag tgtcaagcgc ctcaaaggag tcgaggaacg cttctttctc cgcggacgac
    12541 gaattcacat acgcctcgag ggcagctgga tagtcgttga gtttcaaatc aaagaacacc
    12601 cgcgtgtcga tcaacggcag gttcggatcg gcatccgcag caattgccgc gacttgagct
    12661 tctaccgcgt cacgcccaag gagatcaata agcatgtcgg tagcggtgtt atcgctgatg
    12721 gaaatcatca attcggcggc ctgatagaca gtaacggtct caccggcttg ccgatcttga
    12781 agctctccgg aagggagact acgaatgtcc tcggtgattt cgatgtggtc atcccaggtg
    12841 atgtccccag ccgcgacggc ttgctcaaca gcgtgcaaca caaatatttt gaataccgaa
    12901 ccaactggtt gcatgatggc cgcggaagat tcgtgtacag cctgacattc tccctcgtcg
    12961 atgtccgcgg cgaggaaacc gacgttctcg ctatcggcgg caatgctgtc taggcgagca
    13021 tcgacctcgt cccaactagt cgggctagcg gggagatcca tatcatcggg aggaaggaag
    13081 agcagggtct caatcttgga atcggaatcg atttcgatga tgatgtgaaa atcccctgtg
    13141 ccatggaagg cttcggcccg caagcggctg ggttcgtcat cgagaatgtc ggtaacgatg
    13201 gttccccgca tatcgctcat gatggggtta agatcggcca ccgggacttg gtccaagaac
    13261 gtctgggcga aatgttgttc ggcttcctcc ttctccagtg gcagcgattc caatttgtcc
    13321 aggtaccact ggagtttctc tcccacgggg gtttgcggaa tgtccaccgc cacaggctca
    13381 tcaccgccgg tgtcgccatc atcggattcc gcaccgcccg aacaggcagt caaggccagt
    13441 gtcacagcga ggacagcggc gaacagcatc cgccatcggg ccagtcgagc gtggtcgcgc
    13501 atgtgagtcc ctcgaagcaa gatcgagcgg gccgcagccc caagccgctg atacccgctg
    13561 gtagcaatgg tgagtctcca ccatatgcgg cacgatctgg cctcgacgag cccccatcgg
    13621 gttactgatg gttcggctcc tcgtggctag tgttcctctg accgactggc tgcgggttct
    13681 tctttgcgcg caaccgggcc agttcctccc ggatgaccgc caagttgcgt ttgctggcct
    13741 gcacgtccgg agcttcctcg ggatcgcctg aggagcgttg tacacgggcc agagactctc
    13801 ccagggacac cagttcgcgc tgcaactgag tcagtagcga gcgaccgtct ttgcccaact
    13861 ccttctggat tgccttgcgc tcctgcaaac ggcttcgcag ggatctcatc gaggtcagtt
    13921 cgtcggtgct gatgacccac tcgggctgat tggacatggt gtcgacgaac cagcgccact
    13981 cccgtcgcgc ggccgccgaa tacaacagaa cgaacaaacc tagaatgatc aggccttttc
    14041 cataggtcaa tactaggatg aggcccgcgt tgaggtcggg ggcgaagggc agattccaca
    14101 gggcgtgcat cgccatggag agaacgaaca agctaccggc gacagcggcc ctctgagcgg
    14161 tactgcgccg ccgctgagtc acgaagtagg cgatgcccag ccccgcgacc gcactgtaaa
    14221 gaggatgaga ccaaggccca gccacagcga tgcgaatgat ggtggcgctg agggctcctg
    14281 cccagtcgga gttgggattg ataatcgcga agttgaccgc gtaggtgacg ttttcgacca
    14341 cctggaaacc taggccaatg agcgccccgt agatcagacc atccatgggg cggtggaagt
    14401 gttcccgcac gatgagcacg agtagcacca cccccaaagc cttaaaccat tcctcgttga
    14461 tgggcccggc gatcgctggc ccccaggttc gagcccagtc ggagccaaag ttggccgcga
    14521 agacgatcag ggccgaattg ttggccatca tggacaccgc gatcgaggca atggcgcccc
    14581 acaggaaggc tgccatacgc acagccaccg gctcgcgctc gaacaaatcc agccgggcaa
    14641 gtacccacca aaacgccgct gcgagggcgc cgttgatagc gatggaaacc cacagcgcac
    14701 cggcaatttg gtcgaacgat gggccgagta ccccgccgat attgatgaga ccgaaaacga
    14761 gaagcccggc aaagagccag aaagccggac ggcgcacccg cacgaaagcg ccttggctct
    14821 caacgatgat gcgttcggta tggacggtca cttgacctcc aagagcattg agtcaaggag
    14881 gcgttcgagt tcggtcatcc cttcgtcgag gcgcccggcg ggcgctaggg cgataacggt
    14941 gatagccccg cgagcccggg cggcttgatc atcgcccgat ccgttgcgaa gaacgacgat
    15001 ggccccggac gtagagcggc ctacgaggtc agaccagtac ccgtcaagct gcgcggtgtg
    15061 actgcggtag gggtgcgggc gggaggcgat gacctgggtg ttgttggcga ctacgttgtc
    15121 gctacgacgt tccatgaagc gttccaagtc gtttactccc gcgctgactt ggacggtgag
    15181 ggtgatagag ccccgccgaa tggtggcttc ggcaggggac acactgacgt cgtgttgcca
    15241 acccgaggag gggatggcga agctcagtcg ggccccatct tcggggtagg aattcacggt
    15301 gatcatgctg ccgcgtggag cggcttcgga cagttgggag gctccccgct cgagaaaggt
    15361 ccagaacatg atgggaatgg cgatggccaa cgccacggcc accgctggcc aggtgcgccc
    15421 ctgctccatc ccgaatcggt tgagtcggac ggtcgcctct gccacgcatt cactccctcc
    15481 gtgggtctac ctagtcgatc gctggggcca cttcgggttt tgcctcgaag tggccccttc
    15541 gtcgcgtttc attgtggctg gaatccagag ggctaggtgg gcaaacggcg tactttaccg
    15601 acgggcggaa cacgttggag gagtttgaac gcaaatgaag gaagagcggc taaaagccgc
    15661 tcctccttca tgcccatccg ggggcgagaa aagtatgtag tttgtataaa gtctggcttc
    15721 agcttacagc aagcgctgca cccatccgtg gcggtcctca gcccggccgt gttgcaggtc
    15781 aagcaaggtt tgacgcaact gcatggtcaa cttgccagcc tgggctttcg agatggtgaa
    15841 gtccccatct gcttcgcgca cggttcccac cggggtgatg acagcggcgg tgccgcaggc
    15901 aaacacttcg gtgagcgctc ccgagttggc gtcctcacgc cagcggtcga ggctgtagtc
    15961 gacttcacgc acttcccagc ctgcttcccc agcgagactg atgatggcgt cgcgggtgat
    16021 gccaggcaag atggtgccga gcttgggagt gtatatgact tggtcgttct catatacgaa
    16081 gaaaaggttc atgcctccca gctcatcgac gtacttgcgt tcgaccgcgt cgaggaacac
    16141 tacttgatcg caaccgttct cgatcgcctc ggcctgcgcc gcaaggctgg ccgcgtagtt
    16201 gccgccgcac ttggcagttc cggtaccgcc gggggcggcc cgagtgtact cgcgggagac
    16261 ccaaatggtg acaggcttgg gcccagatgc gaagtaggct ccggccgggg aggcgataag
    16321 cgtgtagagg aattccttcg ccgggcgcac gcctaggaac gcttcggtgg cgaacatgaa
    16381 tggccgcaga taaagactgg cctcagcttg agtcgggacc cagtccttgt cgacgcttac
    16441 cagttgtttg atcgactcca tgaacagatc taccggcagc tgcggcatgg acatgcgctt
    16501 ggccgaggca ttgaagcgac gagcgttggc ttcgggtcgg aagaggccga ctccgccatc
    16561 gtcataacgg taggccttca tgccttcgaa gatttcctgg gcatagtgca gcaccgaggc
    16621 ggcggggtcc aaggtgatcg ggccataggg ctcaacctgc ggctcgtacc atcctttatc
    16681 cacgtggtac ttgatggtca ccatgtggtc ggtaaagaga cgaccgaagc ccgggtttgt
    16741 gaggagctcg gctcgcttcg ccgcgtcagt ggcgtgggga tggggtagct gcgtgaaagt
    16801 cggcagtgcc tcaatcgtca tctggcaagc tccttcagtc gtcaataagt gcggcccgga
    16861 atgttgttca acagggcaca ggtccaacgt actgggccga agccgcagga ggggatgcat
    16921 tcggtgccga gtgattcggc ggatgctctg gcagcgcctg gtgaactagc ttccgatcac
    16981 accctaactt accgttcgtt aaggttggag aaaaccgcta ctgcctacct gcggattcac
    17041 cctggcagtg gcggccttca cttcctgttc caccatcgaa ttcgctaggg gttccctttc
    17101 gcgcccaagc agcgattccc acaaagtcac attcgcttct cgactgcggc ggcgacccgg
    17161 tcacccactt cggcggtgcg caccggctgg ccgggcttac ggtcggcaag ttcggccgca
    17221 cacgcacggc gcacgatgtc ggcgtcttcg gctcgaccta gatggtcgag caacatcgcg
    17281 gccgaaatga tggcggcgat agggtcggca attccctggc cggcgatatc gggggccgat
    17341 ccatgtacgg gctcgaacat cgacggatag ctttgatcag ggttgatgca accggaggcc
    17401 gccaggccga tgccaccggt aatcgcggcg gcgatgtcgg tgaggatatc gccaaacagg
    17461 ttgtcggtga cgatgacgtc gtaagtttcg ggccggtcga ccataaacat cgaagccgcg
    17521 tcgacgtgtt gatagtcagt tgttagttca ggaaagtctc ggacaacctc atcgaaggta
    17581 cgctgccaca ggctacccgc gttgaccagc acattcgtct tatgcacgag ggtaagacgc
    17641 ttgcgttccc gcaatgcggc cagctggcag gcatggcgca cgacccgctc caccccatag
    17701 cgggtattga ggctctcttc ggttgccacc tcagcagagg tgccacgctg gactactccc
    17761 ccggctccgg catagagtcc ttcagttccc tcccggacga ccagaaaatc gatctctccg
    17821 ctcttgactt ctgccagcgg gctgttgact ccaggccaaa gccgcgctgg ccgcaagttg
    17881 acatactggt cgaaatcgaa ccgcagtttc aacagcaatc cgcgctccaa gatgcccggc
    17941 ccaacgctgg ggtcgccgac ggcacctagc aatatcgcgt cgtgatctgc cagctcagct
    18001 tgtaccgatg cgggcaaggc ttcgccagta cgggcgtaac accgggcacc caagtcgaac
    18061 tcggtcgcgg tgtgattggg gagggcaacc tcgagaactt tttgcgcctc ggaaatcact
    18121 tcgcgtccga taccgtctcc ggggattacc gcaatgttgt gcacgaggct gccgcccttt
    18181 cctgctgaag tttctctcgt tcgcgggaag cgtgcacggc ggcctatcga ccggatggtt
    18241 cgcgtcggtc atcgtcttag gaagagccag tgtctgtgcg gattcgcgca cgcttccggg
    18301 tacgcggggc ctgtcgtggg cccgcaacgt cacgaggcca cattacgtgg cctccgcgaa
    18361 ggttagcgca accatcccgc atagcgaaag ccgtctccca atatgtgaac acggcaacgc
    18421 atggccacag gtgaggtgcg gtagaccggc acctcaccta accgttactc cttatcgggg
    18481 cggtcctggt tggccaagaa gtgttcaaag gcggccccga gttcctcggc cgtggggact
    18541 cgcccatcgg caagcatctc gtcactctcg gcctgttcgg taaacgagtc atattgctct
    18601 tcaagcgtgg tgataatctc ttcaacctcg gaattctccg ccacctgttg cgcgatttcc
    18661 tcggccacct cttcccgtga catctccaaa gagctggtgg gcagttccaa gtccgtcgcc
    18721 ttcgcgacgg cctctatcag acgcagcgag gcggccgggt acgacatttg ggtcaaataa
    18781 tgcggaacat gagcggccaa gccgatcgcg tcgcggcccg actggccaag ccggaactgc
    18841 aacaatccag cggcatggcc gggcacctgc atctctgaga acaccggccg gttgtcaaag
    18901 accaactcag ggcgggtcgc gtgcacagtc aggcccaatg gcctggtgtg cggaaccccc
    18961 atcggaatgc cctgtaggcc aacaaccagt gagatcgcga aatagtccac gaggtcttcg
    19021 accgcatcga caaaccgttc ccaggcgaag tcgggttccg ggcccgacaa cagcaaataa
    19081 ggctgtccct gcgcgtctcg caacaaatag acgaccaact ggggggcatc gaagtccgac
    19141 caatggtcga tggagaaagt gaggttaggc cgtcgggacc ggtaatccat caactggtcg
    19201 acatcgaacg acgccaccgg ctggtgatcg ttttcctcca ggagggcttc aaccacgccc
    19261 tttccagccg aacccgcgtc catgaagccc tcaagatgaa gcagcatgac agcaccgcgc
    19321 gcttcaggct cgtccgacag gatgtcgcat agcgaccaac ggtcaatgct caccggtgaa
    19381 ggctccttac gtttgagtac ctctgaatgc taactccgga atacgctttc gcattccacc
    19441 atttccgcgc aaacgagaaa atcaaggatt tttcacattc tggttgcgag cagtgagggc
    19501 acgagcgagg tgtccgtacg ctctcgacgg cgacacatcg gcagctctca ctttcagtgt
    19561 gaacgccatt gaacctcctg acacccactc agacgaatcc ccgcgttgag gccgcccatc
    19621 gccacatccc tctctacggg cagaaccacc cacggcatcg cacccggttc ctcggccatt
    19681 cttcgcacct gcagccgccc accggacaga aagttcacgc caacgcacca tagacggcgc
    19741 atctcatcat gccgtacctc agccccagac attgaactcg ggccggtcgg catcggtcgg
    19801 tgccacccga taatgtccca gcgcgtactc gttgatctgc cgaaaagcat cagccgtgac
    19861 ctcaccaccg ccgccaccac caggtacata ggcgaagacc gccaccgcga actgcgggtc
    19921 ctcggcgggc gcaaagccca caaacgacgc cacatggccg ctagcgtact ctccgtcccg
    19981 cacaagtcca cccgtaccgg tcttacccgc caagtgatag ccgttcaagt cagcccgagt
    20041 accagtaccg gtctcgtgat agatcgttga ctgaagcaaa tattgcatcg cctccgcggt
    20101 ctcgaccgaa atcacgcggc ggtcctcgtt tctttctggc tccaggactt gaccgtctct
    20161 gtcgatcatg ctttgcacca gcgccggatt ggtatagaca ccatcgttgg cgatggtcgc
    20221 gtatacagcc gccatctgga tcggtgtcgt ggtgatctcg tggccgatcg gaatcgaacc
    20281 agcggaagtg cccgaccagt tatcggggtg aaggagcatg ccatcggctt ccccggccac
    20341 ccctactcca ctggaagtgc ctagaccaaa ggccttctga tattcgtaaa gcttttcggg
    20401 ccccaacatg tccgccaaca tgatcgtgcc aacgttggat gattgggcga tgatcccagc
    20461 caacgtcaac ggcactccgc gctgcggata cgagtccgag tacgtcgtgt tgcccttcac
    20521 gatcgtcggc ggaaccacaa tggaaccgtc ccgttcgatc agaccttcct ccaaggcggc
    20581 ggcgatgacg atagccttgt gaaccgaacc agggtcgacc gtcgcctgcg tcgtgtggtc
    20641 gcgatacagc tcctcgtctt ctccaaacgg gttcgccgcg tcaaaggtgg gcagcgaggc
    20701 catggccaag gcctcgccgc tagccacctc cagcaccacg gccgaggccc attcggcgtc
    20761 gtgctcctcc acggtctgat caagaatttt ctgcacctgg aactgcaagt cccaatccag
    20821 cgtcaaccgc aagtcctgac ctggctgggc tggatcttcc cgataaaacg cccccgggat
    20881 cggctggccg gagtggctct gttcgtaagt gacctcaccg tcggtcccag acagccagtt
    20941 attccagcct ccctccagac ccgcgagtcc ctcaccctcg tcgccaccgg tgaagccaat
    21001 gacattcgcg gccaagtcat gtcctgggac gacccggcgt tcatcggcac cgatgatcaa
    21061 ac
//
