LOCUS       NZ_CP070260            22235 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces californicus strain FDAARGOS_1210 chromosome.
ACCESSION   NZ_CP070260
VERSION     NZ_CP070260.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces californicus
  ORGANISM  Streptomyces californicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7919564)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T., Yan,Y.
            and Sichtig,H.
  TITLE     FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
            Supporting development and validation of Infectious Disease Dx tests
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7919564)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T., Yan,Y.
            and Sichtig,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2021) Institute for Genome Sciences, University of
            Maryland School of Medicine, BioPark II, 801 W. Baltimore St., Suite
            619, Baltimore, MD 21201, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT v. 8.0.0, HGAP v. 4
            Genome Coverage                   :: 624.55x
            Sequencing Technology             :: Pacbio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016906265.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 09:02:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,240
            CDSs (total)                      :: 7,147
            Genes (coding)                    :: 7,032
            CDSs (with protein)               :: 7,032
            Genes (RNA)                       :: 93
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 115
            CDSs (without protein)            :: 115
            Pseudo Genes (ambiguous residues) :: 0 of 115
            Pseudo Genes (frameshifted)       :: 36 of 115
            Pseudo Genes (incomplete)         :: 97 of 115
            Pseudo Genes (internal stop)      :: 12 of 115
            Pseudo Genes (multiple problems)  :: 27 of 115
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:25:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7788988
            Orig. end                         :: 7811223
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070260.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22235
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="31"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22235
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22235
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12235](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12235)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    185..199
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            complement(369..1664)
                     /gene="paaK"
                     /locus_tag="I6J40_RS33715"
                     /old_locus_tag="I6J40_33705"
     CDS             complement(369..1664)
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (82-332). E-value: 6.3e-24.
                     Score: 76.2. Matches aSDomain:
                     nrpspksdomains_I6J40_RS33715_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458485.1"
                     /locus_tag="I6J40_RS33715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33705"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_030190173.1"
                     /sec_met_domain="AMP-binding (E-value: 2.1e-26, bitscore:
                     91.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDMLDAAERLGRGELEALQRERLLSTLHHAYTRVPFYRAAFDRA
                     GLRPEDCASLADLARFPFTVKADLRENYPFGMFAVPEREVRRIHASSGTTGRPTVVGYT
                     ERDLDTWADLVARSIRAAGGRPGHKVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGM
                     TARQVRLIQDFRPEIIMITPSYMLTLLDEFEREGVDPRSTSLKVGIFGAEPWTEGMRRE
                     IEDRFAIDAVDIYGLSEVMGPGVAQECVETKDGPHIWEDHFYPEVVDPFTGEVLPDGEE
                     GELVLTSLTKEAMPVIRYRTRDLTRLLPGTARTFRRMEKVTGRSDDMVILRGVNLFPTQ
                     IEEIVLRTPAVAPHFQLRLTRHGRLDALTVFAEARADATTDERERAARSIVAAVKDGIG
                     VSVSVEIVDPESLERSVGKIRRIVDLRDSGTE"
     CDS_motif       complement(639..701)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I6J40_RS33715_0001"
                     /evalue="4.60E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="I6J40_RS33715"
                     /protein_end="342"
                     /protein_start="321"
                     /score="13.0"
                     /tool="antismash"
                     /translation="TGRSDDMVILRGVNLFPTQIE"
     aSDomain        complement(669..1418)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I6J40_RS33715_AMP-binding.1"
                     /evalue="6.30E-24"
                     /label="I6J40_RS33715_AMP-binding.1"
                     /locus_tag="I6J40_RS33715"
                     /protein_end="332"
                     /protein_start="82"
                     /score="76.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="REVRRIHASSGTTGRPTVVGYTERDLDTWADLVARSIRAAGGRPG
                     HKVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGMTARQVRLIQDFRPEIIMITPSYM
                     LTLLDEFEREGVDPRSTSLKVGIFGAEPWTEGMRREIEDRFAIDAVDIYGLSEVMGPGV
                     AQECVETKDGPHIWEDHFYPEVVDPFTGEVLPDGEEGELVLTSLTKEAMPVIRYRTRDL
                     TRLLPGTARTFRRMEKVTGRSDDMVILR"
     gene            1864..3408
                     /locus_tag="I6J40_RS33720"
                     /old_locus_tag="I6J40_33710"
     CDS             1864..3408
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-267). E-value:
                     8.2e-26. Score: 83.0. Matches aSDomain:
                     nrpspksdomains_I6J40_RS33720_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956456.1"
                     /locus_tag="I6J40_RS33720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33710"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_030190175.1"
                     /sec_met_domain="PF00561 (E-value: 1e-20, bitscore: 73.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.8e-18, bitscore:
                     64.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIFAAYDTTPLAYRLVGEGEPLICLPGGPMRASAYLGDLGGLAA
                     RRRLVLLDLRGTGDSAVPEDPATYRCDRLVDDVEALREHLGLDRIDVLAHSAGADLALL
                     YAARHPERLRTLTLVTPSTRAVGIEVTGQDLREAAELRRDEPWYPEARAAQDALLAGGP
                     FAELWPAVRPLTYGRWDEAARAHAGASAGQTNAEARARYSEEGAFDPVATAAALRGTAV
                     PVLVLAGEYDGHPRPDRATELAALFPYAEFAVQRGAGHFPWLDDPGAFARTVAAFLDPE
                     IRTVQAGGIRLAYREWGQEGAPPVVLLHGRSGSSAGWARIARDLAVDHHVYAPDFRGHG
                     LSDWPGRYSFETFRDDLHAFLEARNLAGATVVGHSMGGVAAYLLAQREPDLIGRLVIED
                     APPLLPLDPPRPPAVRPEGPLDFDWPVVPDTDAQINDPDPDVPLRLPEITAPTLVIGGG
                     PTSHIDQEQLARMTRAIPGATSVTIDAGHLVHTDRPEEFLAAIREFGLTDRPGGVR"
     aSDomain        1927..2664
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I6J40_RS33720_Abhydrolase_1.1"
                     /evalue="8.20E-26"
                     /label="I6J40_RS33720_Abhydrolase_1.1"
                     /locus_tag="I6J40_RS33720"
                     /protein_end="267"
                     /protein_start="21"
                     /score="83.0"
                     /tool="antismash"
                     /translation="PLICLPGGPMRASAYLGDLGGLAARRRLVLLDLRGTGDSAVPEDP
                     ATYRCDRLVDDVEALREHLGLDRIDVLAHSAGADLALLYAARHPERLRTLTLVTPSTRA
                     VGIEVTGQDLREAAELRRDEPWYPEARAAQDALLAGGPFAELWPAVRPLTYGRWDEAAR
                     AHAGASAGQTNAEARARYSEEGAFDPVATAAALRGTAVPVLVLAGEYDGHPRPDRATEL
                     AALFPYAEFAVQRGAGHFPWLDDP"
     CDS_motif       2146..2184
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I6J40_RS33720_0001"
                     /evalue="6.30E+00"
                     /label="NRPS-te1"
                     /locus_tag="I6J40_RS33720"
                     /protein_end="107"
                     /protein_start="94"
                     /score="-0.4"
                     /tool="antismash"
                     /translation="HSAGADLALLYAA"
     CDS_motif       2974..3024
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I6J40_RS33720_0002"
                     /evalue="3.90E-05"
                     /label="NRPS-te1"
                     /locus_tag="I6J40_RS33720"
                     /protein_end="387"
                     /protein_start="370"
                     /score="16.2"
                     /tool="antismash"
                     /translation="VVGHSMGGVAAYLLAQR"
     gene            complement(3534..5180)
                     /locus_tag="I6J40_RS33725"
                     /old_locus_tag="I6J40_33715"
     CDS             complement(3534..5180)
                     /NRPS_PKS="Domain: AMP-binding (8-446). E-value: 4.9e-67.
                     Score: 218.2. Matches aSDomain:
                     nrpspksdomains_I6J40_RS33725_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382252.1"
                     /locus_tag="I6J40_RS33725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33715"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_030190177.1"
                     /sec_met_domain="AMP-binding (E-value: 5.5e-68, bitscore:
                     228.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESVVDVVPDREALLYVDHPGTGAERRLTYAELDASA
                     NRIAHHLIDAGIRPGEHLGLHLYNGVEYLQTVLGALKARIVPVNVNYRYVEEELVYLYR
                     DADLAALVFDGEFDERVAAAAPQATGVRHLIRVGPAPTARTGPSPAAPPGPPVVPFGEA
                     ERSGSAGRGFASRSGDDQFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGDPVKSPG
                     ELARRVAAGGDGITFFPTPPLMHGTSTLTAFIGFNFGQRVVVHRKFVPEEVLRTIEREK
                     VTSVSLVGDAMLRPLIDCLKGPCRGTDCSSLFSVSSSGAVMSDSVRAELQALVPTVMLL
                     NNFGSSESGFNGTATADSGPENGFRVRVNARTAVVDPATHEPVAPGEPGRIAQRGHVPL
                     GYYNDPAKTADTFFHRGGERWVLLGDMATVDADGIVTVLGRGSQCINTGGEKVYPEEVE
                     QALKSHPDVYDALVAGVPDERWGNRVAAVIQLRDSTGTLSLAAVQEHCRSRLAGYKIPR
                     ALVLADRIRRSPSGKADYRWAKAVAAEDGRA"
     aSDomain        complement(3843..5156)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I6J40_RS33725_AMP-binding.1"
                     /evalue="4.90E-67"
                     /label="I6J40_RS33725_AMP-binding.1"
                     /locus_tag="I6J40_RS33725"
                     /protein_end="446"
                     /protein_start="8"
                     /score="218.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESVVDVVPDREALLYVDHPGTGAERRLTYAELDASANRIAHHLI
                     DAGIRPGEHLGLHLYNGVEYLQTVLGALKARIVPVNVNYRYVEEELVYLYRDADLAALV
                     FDGEFDERVAAAAPQATGVRHLIRVGPAPTARTGPSPAAPPGPPVVPFGEAERSGSAGR
                     GFASRSGDDQFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGDPVKSPGELARRVAA
                     GGDGITFFPTPPLMHGTSTLTAFIGFNFGQRVVVHRKFVPEEVLRTIEREKVTSVSLVG
                     DAMLRPLIDCLKGPCRGTDCSSLFSVSSSGAVMSDSVRAELQALVPTVMLLNNFGSSES
                     GFNGTATADSGPENGFRVRVNARTAVVDPATHEPVAPGEPGRIAQRGHVPLGYYNDPAK
                     TADTFFHRGGERWVLLGDMATVDADGIVTVLGRGSQCIN"
     CDS_motif       complement(3945..3992)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I6J40_RS33725_0002"
                     /evalue="3.80E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="I6J40_RS33725"
                     /protein_end="412"
                     /protein_start="396"
                     /score="12.9"
                     /tool="antismash"
                     /translation="VPLGYYNDPAKTADTF"
     CDS_motif       complement(4587..4637)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I6J40_RS33725_0001"
                     /evalue="3.10E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="I6J40_RS33725"
                     /protein_end="198"
                     /protein_start="181"
                     /score="19.8"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVMW"
     misc_feature    complement(5275..5289)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.75"
                     /tool="antismash"
     misc_feature    complement(5277..5293)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    complement(5279..5294)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     gene            5347..6147
                     /locus_tag="I6J40_RS33730"
                     /old_locus_tag="I6J40_33720"
     CDS             5347..6147
                     /NRPS_PKS="Domain: ECH (9-258). E-value: 1.5e-53. Score:
                     173.6. Matches aSDomain:
                     nrpspksdomains_I6J40_RS33730_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550728.1"
                     /locus_tag="I6J40_RS33730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33720"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_030190178.1"
                     /transl_table=11
                     /translation="MGGTEHLAVRREGATLVLTLNRPQAKNALSLPMLVGLYDGWLAAD
                     ADDTVRSVVLTGAGGAFCAGMDLKALAGDGMEGEEYRERMTADPDLHWKAMLRHHRPRK
                     PVIAAVEGPCVAGGTEILQGTDIRIAGAGAVFGLFEVRRGLFPIGGSTVRLPRQIPRTH
                     ALEMLLTGRSYTADEAAAIGLVGRVVPDGTALEEALAVADRVNACGPLAVEAVKASVYE
                     GADLTESEALAAELRRGWPVFATEDANEGARAFAEKRSPVYRRV"
     aSDomain        5374..6120
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I6J40_RS33730_ECH.1"
                     /evalue="1.50E-53"
                     /label="I6J40_RS33730_ECH.1"
                     /locus_tag="I6J40_RS33730"
                     /protein_end="258"
                     /protein_start="9"
                     /score="173.6"
                     /tool="antismash"
                     /translation="RREGATLVLTLNRPQAKNALSLPMLVGLYDGWLAADADDTVRSVV
                     LTGAGGAFCAGMDLKALAGDGMEGEEYRERMTADPDLHWKAMLRHHRPRKPVIAAVEGP
                     CVAGGTEILQGTDIRIAGAGAVFGLFEVRRGLFPIGGSTVRLPRQIPRTHALEMLLTGR
                     SYTADEAAAIGLVGRVVPDGTALEEALAVADRVNACGPLAVEAVKASVYEGADLTESEA
                     LAAELRRGWPVFATEDANEGARAFAEK"
     gene            6185..7132
                     /locus_tag="I6J40_RS33735"
                     /old_locus_tag="I6J40_33725"
     CDS             6185..7132
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382254.1"
                     /locus_tag="I6J40_RS33735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33725"
                     /product="OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_030190180.1"
                     /transl_table=11
                     /translation="MSDVLSAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRTDDGTV
                     LVPPVEYDPVTANELRDLVEVAPTGTVTTWAWNPSPRRDQPLDTPFAWVLVRLDGASTA
                     LLHALDAPGPESVRTGMRVRVRWAATRTGAITDIACFEPYEGAAAGGEPAPHTGEFADP
                     VTGIVAPARLDYTHTPGRAQSAYLAALEGRRTVGERCPACRKVYVPPRGACPTCGVATA
                     EQVEVGPRGTVTTFCIVNIKAKNLDIEVPYVYAHIALDGADLALHGRIAGIPYDQVRMG
                     LRVEPVWVDGVRHPDHYRPTGEPDADYDTYKELV"
     gene            7133..8185
                     /locus_tag="I6J40_RS33740"
                     /old_locus_tag="I6J40_33730"
     CDS             7133..8185
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550730.1"
                     /locus_tag="I6J40_RS33740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33730"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_030190183.1"
                     /transl_table=11
                     /translation="MRDVAIVAFAQSAHRRRTDELSEVDLLMPVLHEVLGATGLRANEI
                     GFTCSGSADYLAGRAFSFTMALDGVGAHPPISESHVEMDGAWALYEAWVKIMTGEADTA
                     LVYSYGKSSPGRVRDVLTRQLDPYYLAPLWPDSVALAALQAQALIDAGDTDEPALARIA
                     ARNRAAAVDNPYAQLTGDVPAGDHLVRPLRTGDCPPVGDGAAAVILAAGDTARALCARP
                     AWIRGIDHRIEAHALGVRDLTDSPSTRLAAERAGAFERPVDTAEVHAPFTSQEVVLRKA
                     LRLGDEVRVNPSGGALAANPIMAAGLIRLGEAAARVHRGESDRALAHATSGPCLQQNLV
                     AVLEGESAHA"
     gene            8178..9344
                     /locus_tag="I6J40_RS33745"
                     /old_locus_tag="I6J40_33735"
     CDS             8178..9344
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971158.1"
                     /locus_tag="I6J40_RS33745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33735"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_030190186.1"
                     /transl_table=11
                     /translation="MRKEPVAVVGVGQTKHVAARHDVSIAGLVREAAVRALEDAGLAWS
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVAANLVAAR
                     VHRTVLTLAFEKQSESNAMWGLSLPVPFQQPLLAGAGGFFAPHVRAYMRRTGAPDTVGS
                     LVAYKDRRNALKNPYAHLHDHGITLEQVQSSPMLWDPVRYSETCPSSDGACAMVLTDRD
                     GATRSPHPPAWVHGGAMRSEPTLFAGKDFVSPRAGRDCAADVYRQAGITDPRREIDAVE
                     MYVPFSWYEPMWLENLGFADEGEGWKLTEAGVTELDGDLPVNPSGGVLSTNPIGASGMI
                     RFAEAALQVRGRAGEHQVDGAARALGHAYGGGAQFFAMWLVGSQPPPG"
     gene            9421..9921
                     /locus_tag="I6J40_RS33750"
                     /old_locus_tag="I6J40_33740"
     CDS             9421..9921
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="I6J40_RS33750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33740"
                     /product="hypothetical protein"
                     /protein_id="WP_030116957.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQG
                     VFLRYDLYGGRGPAMIIGNLPEGSPARETEEGQVPFEVAQLLLALENDEPIEVVSTEDV
                     PVMQGDNLLIVRRVKLSESRISCVQFDRSDGVLVTIASWDRPITDDLYTLLKPLPAELF
                     QQG"
     gene            complement(10001..12235)
                     /locus_tag="I6J40_RS33755"
                     /old_locus_tag="I6J40_33745"
     CDS             complement(10001..12235)
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382258.1"
                     /locus_tag="I6J40_RS33755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33745"
                     /product="terpene synthase family protein"
                     /protein_id="WP_030190189.1"
                     /sec_met_domain="T1TS (E-value: 6.1e-85, bitscore: 284.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPFSLPDFYVPYPARLNPHLETARTHTREWARSMGMLEGSGIW
                     EEKDLEAHDYALLCAYTHPDCSAEALSLVTDWYVWVFFFDDHFLELFKRTPDREGAKRY
                     LDRLPAFMPMERGAALPEPENPVEAGLADLWTRTIPAMTDGWRARFAESTENLLNESLW
                     ELSNIHEGRIANPVEYIEMRRKVGGAPWSAGLVEYAAGAEVPDRVAASRPLRVLRDAFS
                     DAVHLRNDLFSYQREVEDEGENSNGVLVLETFLGCSTQEAAEAVNDLLTSRLQQFENTV
                     LTELGPLCAEKRLGPEETAAVLAYAKGLQDWQSGGHEWHMRSSRYMNGGGAGEAVPGFG
                     MSAASLRFTLRSETARARSHSHVPYRHVGPSILPDFDLPYTTTLSPHLEGARVRVVDWA
                     RRMGILQAQPGVPGSHIWDEDRIRAIDLPLCAAGIHPDATPDGLDLSSAWLAWGTYGDD
                     WFPVVHGRTRDLAGARLANERLSLFMPLDGEGTPEPVNALERSLGDLWDRTAGPMDAGA
                     RRAFRTAIETMTASWLWELSNQAQNRVPDPVDYVEMRRATFGSDLTMSLCRLGHGKRVP
                     EEVYRSGPLRSLENAAADYACLLNDLFSYQKEIEYEGEVHNGALVVQNFFGVDYPTGVA
                     IVHDLMNSRLRQFRHVADVELPALYDDFDLDAEAREVLAGYVRELEHWLAGILIWHRGC
                     RRYREEDLRRVHGAPWHLGGPVGLGTSAAQVTRLMVRETVGTASGASGGS"
     gene            complement(12416..13078)
                     /locus_tag="I6J40_RS33760"
                     /old_locus_tag="I6J40_33750"
     CDS             complement(12416..13078)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971163.1"
                     /locus_tag="I6J40_RS33760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33750"
                     /product="transglycosylase SLT domain-containing protein"
                     /protein_id="WP_030190191.1"
                     /transl_table=11
                     /translation="MPRISTLRITRSHQIAAAVLVAAGSVTAIAATGGTSEAQTSAARS
                     SVSVEPVAAAGIPTAKDAAEKAAEQKAAESAAAKKAADRAAAHKAAEARSDKQAANRST
                     ERKAVTPKKFSNNLDGWIRESLDIMKKKNIPGSYEGLHRNIMRESSGNPNAVNDWDINA
                     RNGIPSKGLLQVIQPTFDAYHVKGTPKKLTDPVANITAAANYAADRYGSIDNVDSAY"
     misc_feature    13237..13251
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.44"
                     /tool="antismash"
     misc_feature    13243..13259
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.61"
                     /tool="antismash"
     gene            complement(13590..14726)
                     /locus_tag="I6J40_RS33765"
                     /old_locus_tag="I6J40_33755"
     CDS             complement(13590..14726)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="I6J40_RS33765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33755"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_030190193.1"
                     /sec_met_domain="APH (E-value: 1.8e-17, bitscore: 62.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTASSSVSAPPRPLRPMGASAGPYLAPHAGAPAQGPGRARRAPG
                     PGAGPLSGRIDLSGPQGAQVRMAIASVQRVCPEFNPVQVLRRSGRSVLIVGTTGRATAV
                     AKCLLDHSPAWTERFRHEIAAYRAFVRHRPPVRAPRLIAADPENCTLVIERMPGRVAAL
                     TRHPAEAPPRADIRAALGAISRVNAWRPPPGLFEAPLDYASRITRYHELGLFTDRDFDD
                     LQKLLHGLAQASGRQGMGQFCHGDALLSNILLSPTGPVLVDWEHAGWYLPGYDLATLWA
                     VLGDAPVARRQISQLAQARGPAARDAFLVNLMLVLTREIRNYETAVQRTMREAPPVAAG
                     SERPGLLSSGEEQRLLLRRLHDDCAMARRAVRAAVGTR"
     misc_feature    complement(14403..14405)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14958..16448
                     /locus_tag="I6J40_RS33770"
                     /old_locus_tag="I6J40_33760"
     CDS             14958..16448
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606686.1"
                     /locus_tag="I6J40_RS33770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33760"
                     /product="hypothetical protein"
                     /protein_id="WP_030190194.1"
                     /transl_table=11
                     /translation="MTGEPNTRFSDLFGLAGWSKGELARLVNRQAAAMGHPQLATDTSR
                     VRRWIDMGESPRDPVPEVLAALFTERLGRVVTIEDLGFGRRGRVGKRRDSGTDDDPDRL
                     PWAPERTAAVLTEFTGMDLMLNRRGLVSAGAALTAGSTIAGPMYEWLRNAPAPAAEAPR
                     ANTPAHADPAGFDRYEAAPVGSEEIEALEYSVEVFRRWDASRGGGLQRKAVVGQLNEVG
                     GMLAYRHPDHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGGDRPRA
                     GEALSRAARQMVHLGRPDDALDLMKLAKSGSGDETLPRTQAMLRTIEAWAQASMGRGQA
                     MRRTLGEAEELFTSDKGDVPAPSWMQMFDEADLHGMQALAFRTLAEHDRSAAVIAQRHA
                     KQALELRDGDRRRSKIFDYISLASACFIANDPEQADRYARLALVSMGETSSHRTWDRLR
                     EMYRLTGQFAGHTGVQDLRAEIEHVMPPAGKKSGGAET"
     misc_feature    15000..15015
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.26"
                     /tool="antismash"
     gene            complement(16499..17929)
                     /locus_tag="I6J40_RS33775"
                     /old_locus_tag="I6J40_33765"
     CDS             complement(16499..17929)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956434.1"
                     /locus_tag="I6J40_RS33775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33765"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_030190195.1"
                     /transl_table=11
                     /translation="MPSPLFADRPAPRPPARDAVNALIQRTRRLRGDVDAVRRDALLFD
                     EDDAGRRRQRALYELAVQYLDGLDENLGRLRSGLTGQDTEGREAEDGTAPEAPGRGTPS
                     YGVGSAEWNLLTDECAWSDELYEIFGRPPGSAPLSLDDLPSVLLPEDQPLLTAMVTGCL
                     VDGRAMDGEFRIVRADGRTRTLHMTGEPVLDADGCTASMWAVLRDVTERRRDEPSVRRT
                     GAAVRRADHGERTEHRMAVELQESVLPPWRGSPPLPRQGPGALDVAAHYLRSGPGGLIG
                     GDWYDAMELPDGRTLLTVGDLTGSGVPATSSMAMMLGALRGMAVAGIEPGPLMGHLNQV
                     LETSVQPTLGSALCCRFDPATSLLSWAQAGHPAPLLFRHSSGRPLPPPDGVLLGAASHV
                     PYEQDEVRLFPGDVLVLHTAGLMRHDTRGAGPEALLALAPRFARARTAQECVRSVVEVF
                     GGAERQDDACVLVARVGA"
     misc_feature    complement(18077..18091)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.0"
                     /tool="antismash"
     misc_feature    complement(18083..18098)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.2"
                     /tool="antismash"
     misc_feature    complement(18178..18192)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.29"
                     /tool="antismash"
     misc_feature    18179..18190
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.7"
                     /tool="antismash"
     misc_feature    complement(18179..18194)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.81"
                     /tool="antismash"
     gene            18238..18402
                     /gene="rpmG"
                     /locus_tag="I6J40_RS33780"
                     /old_locus_tag="I6J40_33770"
     CDS             18238..18402
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192346.1"
                     /locus_tag="I6J40_RS33780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33770"
                     /product="50S ribosomal protein L33"
                     /protein_id="WP_030190196.1"
                     /transl_table=11
                     /translation="MARSETRPVVTLRSTAGTGRSYVTRKNRRNDPDRLELRKFDSAAG
                     RHVLFREVR"
     gene            18481..18741
                     /locus_tag="I6J40_RS33785"
                     /old_locus_tag="I6J40_33775"
     CDS             18481..18741
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524491.1"
                     /locus_tag="I6J40_RS33785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33775"
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="WP_030190198.1"
                     /transl_table=11
                     /translation="MKPRIHPLSRPVVFRDRAAGTAFLTRSTADSGERVVWEDGDSYPV
                     IDVETSSASHPFYTGGRQVLDVAGRVERFHRRYGDGGPSAG"
     gene            complement(19108..19608)
                     /locus_tag="I6J40_RS33790"
                     /old_locus_tag="I6J40_33780"
     CDS             complement(19108..19608)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971171.1"
                     /locus_tag="I6J40_RS33790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33780"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_030190200.1"
                     /transl_table=11
                     /translation="MSDDKKRDLLAEADRLREDGRPEEARERLLALTAALPDDAEVAYR
                     TAWVHDTLGLESEAVPYYERALGNPGLGAEDRRGALLGLGSTYRVLGRYGQAVETLRRG
                     VEEFPDDGALRTFLAMALFNTDEHHEAMRLLLEVTAATSQDPYVQRYRRAIEHYAKDLD
                     ETV"
     gene            19724..20521
                     /locus_tag="I6J40_RS33795"
                     /old_locus_tag="I6J40_33785"
     CDS             19724..20521
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956429.1"
                     /locus_tag="I6J40_RS33795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33785"
                     /product="VanZ family protein"
                     /protein_id="WP_050494176.1"
                     /transl_table=11
                     /translation="MTAEVNPPVRQGTWVRVLVRGAVLVVALLGLVAFSVLLAKVTLTP
                     SPASEDLVTSNLRPGRSLRQYAEDYTFLAACKQAGGNLLLGVPFGLLLPFFVQRRLRMI
                     RTTLLAAVVMTVVELIQGALVTGRAFDIDDVILNTTGAVLGYFLLGRRISHRYYVYTDD
                     TAVPDTSAKPKAERDAGTERETDRPAGRRIPPKPSAGPEHTPATARTRTGPLARLRPAP
                     KDQGPAPAGQRPSRVRGTGGPQGGTAPAPSKSPRALLDRFRRH"
     gene            20678..21472
                     /locus_tag="I6J40_RS33800"
                     /old_locus_tag="I6J40_33790"
     CDS             20678..21472
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458442.1"
                     /locus_tag="I6J40_RS33800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_33790"
                     /product="DUF4389 domain-containing protein"
                     /protein_id="WP_030190203.1"
                     /transl_table=11
                     /translation="MAEPEGRWSPGRTEADADEFRPVLEIVQPARQRRLTVLLRLLLLI
                     PHFIVLFVLHIAAFFTVIVGWFAALVLGRLPDPVFRFLSGVLGYDMRVSASDMLLIDRY
                     PPFALTPPADYPARIEVRPTPLNRLAVLFRVFLMIPAAIVQSLAVYGWWALAFVWWLIT
                     LVLGRMPRPLFEATTATLRYRMRFTAYVMMLTPAYPKGLFGDDAFAGATRAPHPGARPL
                     VLSSAAKWLVVLFLVLGLAGHVTSSVTASTTDDTPATRLLGP"
     misc_feature    21779..21788
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(22100..22114)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
ORIGIN
        1 aggtcgaacc gccgatcccc gcaggtcggg gcggcgggcg aagaccgccg ccgctgttcg
       61 aatccggggc gacgcgcggg ggccgactcc ctgttcatga tgtcctccgt ctgggcggcc
      121 ggttggtact ggtgctccaa gaacgcgccg gatccggggc cgtaacggct cagtgcgggt
      181 gaatatctcg aacatcgatg cggttggggc gggtggggca agggccactc ggccgggcgc
      241 ccttcaatcc acacgttcga gtggtcggcg gtgttcggaa ccccggcagg gcgccgtggg
      301 aggaaccggg gcgggaccgc gcggccggcc cccgcgggtc acagccggcc gcgcgtgccg
      361 ccgggcccct actccgtgcc ggagtcccgc aggtccacga tccgccggat cttgcccacc
      421 gagcgctcca gcgactccgg gtcgacgatc tcgacgctca ccgacacccc gatgccgtcc
      481 ttcaccgccg ccacgatgga ccgggcggcc cgctcccgtt cgtcggtcgt cgcgtccgcc
      541 cgcgcctccg cgaacaccgt cagcgcgtcg agccgtccgt gccgggtcag ccgtagctgg
      601 aagtgcgggg cgacggcggg cgtacggagt acgatctcct cgatctgggt ggggaagagg
      661 ttgaccccgc gcaggatcac catgtcgtcg ctgcggccgg tgaccttctc catccggcgg
      721 aacgtccgcg ccgtccccgg cagcagccgc gtcagatccc gggtgcgata gcggatcacc
      781 ggcatcgcct ccttggtcag cgacgtgagg accagctccc cctcctcgcc gtccggcagc
      841 acctcaccgg tgaaggggtc caccacctcc gggtagaagt ggtcctccca gatgtgcggt
      901 ccgtccttcg tctccacgca ctcctgggcc acccccggcc ccatcacctc cgagagcccg
      961 tagatgtcca ccgcgtcgat ggcgaaccgg tcctcgatct cccggcgcat cccctcggtc
     1021 cacggctcag cgccgaagat cccgaccttc agggacgtcg aacgcggatc gaccccctcc
     1081 cgctcgaact cgtccaggag cgtcagcatg tacgacggcg tgatcatgat gatctcgggc
     1141 cggaagtcct ggatcaggcg gacctggcgc gcggtcatgc caccggaggc cgggatcacc
     1201 gtgcagccga gccgctccgc cccgtagtgc gcgccgagcc cgccggtgaa cagtccgtag
     1261 ccgtaggcca catggacctt gtgtccggga cgcccgcccg ccgcccggat cgaccgggcc
     1321 accaggtccg cccaggtgtc caggtcccgt tcggtgtacc cgacgaccgt cgggcgcccg
     1381 gtcgtgccgc tggaggcgtg gatcctgcgc acctcccgct ccggcacggc gaacatcccg
     1441 aaggggtagt tctcccgcag atccgccttc acggtgaacg ggaaccgggc cagatccgcg
     1501 agcgaggcgc agtcctcggg ccgcagcccg gcccggtcga aggccgcccg gtagaagggg
     1561 acacgggtgt acgcgtggtg cagcgtggac agcagccgct cccgttgcag ggcttccagc
     1621 tcgccccggc ccagcctttc cgccgcgtcc agcatgtccg tcatcgagac ccttccttcc
     1681 agcgcgggag acagacggga cggcccgcag gccgcccggg gcgaccgatc attcggtcga
     1741 ccgcccggaa gcagtaattc aggcggcccg gggggctggc aagaggcgcg cggcggtcgc
     1801 ggacgatcag cccgccgcga accccgctgc gcgcgcccgc gggttcctgt ttggatggcg
     1861 ggcatgccga tcttcgccgc gtacgacacg accccgctcg cctaccgcct ggtgggggag
     1921 ggggagccgc tcatctgcct tcccggcggg cccatgcggg cgagcgcgta tctgggcgac
     1981 cttggcgggc tcgcggcccg tcggcggctc gtcctgctgg acctgcgcgg caccggggac
     2041 tccgccgtgc ccgaggaccc cgcgacctac cgctgcgacc gcctcgtcga cgacgtggag
     2101 gccctgcgcg agcatctcgg cctcgaccgg atcgacgtac tggcgcactc cgccggggcg
     2161 gacctggccc tgctgtacgc cgcccggcac cccgagcggc tgcggaccct gaccctcgtg
     2221 acgccgagca ccagggccgt gggcatcgag gtgaccggcc aggacctgcg cgaggccgcc
     2281 gaactgcgcc gcgacgaacc ctggtacccc gaggcccggg ccgcccagga cgccctgctc
     2341 gccggcggtc ccttcgccga actgtggccc gccgtccggc ccctcaccta cggccgctgg
     2401 gacgaggcgg cccgcgccca cgccggggcg tccgccgggc agaccaacgc cgaggcccgc
     2461 gcacgctact ccgaggaagg ggccttcgac cccgtggcga cggccgccgc cctgcgcggg
     2521 acggccgtcc ccgtcctggt cctcgccggg gagtacgacg gccatccgcg ccccgaccgg
     2581 gccacggagc tggccgcgct cttcccgtac gccgagttcg ccgtccagcg cggcgccggg
     2641 cacttcccct ggctggacga tcccggggcc ttcgcccgca cggtggcggc gttcctggac
     2701 ccggagatcc gcacagtcca ggcgggcgga atccggctgg cgtaccgcga gtggggtcag
     2761 gagggagccc cgcccgtcgt cctgctgcac ggcaggtccg gctcgtccgc cggctgggcc
     2821 cggatcgccc gggacctcgc cgtcgaccac cacgtgtacg cccccgactt ccgcggccac
     2881 gggctgagcg actggcccgg ccgctactcc ttcgagacgt tccgcgacga tctgcacgcc
     2941 ttcctggagg cccgcaacct ggccggcgcg accgtcgtcg ggcactccat gggcggggtc
     3001 gccgcctacc tcctggccca gcgcgaaccc gacctgatcg ggcggctcgt catcgaggac
     3061 gccccacccc tcctcccgct cgacccgccc aggccgcccg ccgtccgccc cgagggcccc
     3121 ctcgacttcg actggcccgt cgtccccgac accgacgccc agatcaacga ccccgacccg
     3181 gacgtcccgc tgcgcctccc ggagatcacc gcgccgaccc tcgtcatcgg cggcggcccc
     3241 accagccaca tcgaccagga acagctcgcg cggatgaccc gcgccatccc gggcgccacg
     3301 tcggtcacca tcgacgccgg acacctggtc cacaccgacc ggccggagga attcctcgcg
     3361 gcgatcaggg agttcggcct cacggaccgg cccgggggcg tgcgctgacc gggtgggcgt
     3421 cggccccgga ccgcccggcg ggccgttctc gacaccccgc gtcccgttcc cggcgcgcca
     3481 cggggtccga cgatcacatc gatcgcgggc cggacgtatg acggcgcggg tcctcaggcc
     3541 cgtccgtcct ccgccgccac cgccttcgcc caccggtagt ctgccttgcc gctcggcgaa
     3601 cgccggatgc ggtcggccag caccagggcc cgcgggatct tgtatccggc gagcctgctc
     3661 cggcagtgct cctgcactgc cgccaggctc aacgtcccgg tactgtcgcg cagttggatc
     3721 acggcggcga cccggttgcc ccaccgctcg tcggggacgc ccgcgaccag ggcgtcgtac
     3781 acgtccggat gggacttgag cgcctgctcg acctcctccg gatagacctt ctcgcccccg
     3841 gtgttgatgc actgggagcc ccggccgagg acggtgacga tgccgtccgc gtccaccgtc
     3901 gccatgtcgc ccagcagcac ccaccgttcg ccgccccggt ggaagaaggt gtcggcggtc
     3961 ttggccgggt cgttgtagta gccgagcggc acgtgcccgc gctgggcgat gcggcccggc
     4021 tcgccggggg ccaccggctc gtgcgtcgcc ggatcgacca ccgccgtacg ggcgttgacc
     4081 cgcacccgga aaccgttctc gggccccgag tcggcggtcg ccgttccgtt gaacccggac
     4141 tcggacgagc cgaagttgtt cagcagcatc accgtcggca cgagcgcctg gagctccgcc
     4201 cgcaccgagt ccgacatgac ggccccggag ctggagaccg agaacagcga cgagcagtcc
     4261 gtgccgcggc agggcccctt caggcagtcg atcagcggac gcagcatcgc gtcgcccacc
     4321 agcgacacgc tggtgacctt ctccctctcg atcgtccgca gtacttcctc ggggacgaac
     4381 ttgcggtgca cgacgacgcg ttgaccgaag ttgaagccga tgaacgcggt cagcgtggag
     4441 gtcccgtgca tcagcggcgg agtggggaag aaggtgatcc cgtcgccgcc cgccgcgacc
     4501 cgccgggcca gctcgccggg cgacttcacc ggatcaccgg tcggcgcccc gccgcccaga
     4561 ccggagaaga acaggtcctc ctggcgccac atcaccccct tgggcatgcc ggtggtgccc
     4621 ccggtgtaga tgatgaactg gtcgtcgccg gaccgggacg cgaacccccg gccggccgaa
     4681 cccgacctct ccgcctcacc gaacggcacg accggcgggc ccgggggagc ggccggtgaa
     4741 ggtcccgtac gggccgtcgg cgcgggcccc acccggatca gatgccgcac ccccgtggcc
     4801 tgcggcgccg ccgccgcgac ccgctcgtcg aactccccgt cgaagaccag cgccgccagg
     4861 tccgcgtccc ggtagaggta gaccagttcc tcctccacat agcggtagtt gacgttcacc
     4921 gggacgatgc gggccttgag ggcgcccagc accgtctgga ggtactccac cccgttgtag
     4981 aggtgcagcc ccaggtgctc gcccggccgg atgcccgcgt cgatgagatg gtgggcgatc
     5041 cggttggccg aggcgtccag ctccgcgtag gtgagccgtc gctccgctcc cgtaccgggg
     5101 tggtcgacgt agaggagcgc ctcacggtcc ggcaccacgt ccacgaccga ctcgaacagg
     5161 tcggcaaggt tgtactccac cgttcctcct ggtcccgggg cgactggcgg cacgggcgtc
     5221 attagagcgc cgggcggcac aagtgggaag gggtggcgcc gaaagaatct gacgagctgt
     5281 cagaaaacta ttgaactgtg tcctctcctc ctgcaacctg ttcccctccg cagacgggag
     5341 tcggtcatgg gcggtacgga acacctcgcc gtgcggcgcg aaggcgccac gctggtcctc
     5401 acgttgaaca ggccgcaggc gaagaacgcg ctgtcgctgc cgatgctcgt gggcctgtac
     5461 gacggatggc tcgcggccga cgcggacgac acggtccgct ccgtcgtcct caccggcgcg
     5521 ggcggggcgt tctgcgcggg catggacctc aaggcgctgg cgggcgacgg catggagggg
     5581 gaggagtacc gcgagcggat gaccgccgac cccgatctcc actggaaggc gatgctgcgc
     5641 caccaccgcc cccgcaagcc ggtcatcgcc gcggtggagg gcccctgtgt cgcgggcggc
     5701 accgagatcc tccagggcac cgacatccgc atcgccggag ccggagccgt gttcgggctc
     5761 ttcgaggtgc gccggggcct cttcccgatc ggcggctcca ccgtccgcct gccccgccag
     5821 atcccccgca cccacgccct cgaaatgctc ctcaccggcc gctcgtacac cgccgacgag
     5881 gccgccgcca tcggactcgt cggcagagtc gtgcccgacg ggaccgcact ggaggaggcc
     5941 ctcgccgtcg ccgaccgcgt caacgcctgc ggcccgctcg ccgtcgaggc cgtcaaagcc
     6001 tcggtctacg agggcgccga cctgaccgag agcgaggccc tggccgccga actgaggcgc
     6061 ggctggccgg tgttcgccac cgaggacgcc aacgagggcg cccgcgcctt cgccgagaag
     6121 cgttcgcccg tctaccggcg cgtctgatcc caggacccgg cgcgcccgat accaggagag
     6181 agccatgtcc gacgtcctca gcgccccgtt ggtggtcgag ttccccttca cccgctccct
     6241 cggccccgtc cagagcgcct tcctcaccgg gctccgcgag cgcaccgtcc tcggcgtccg
     6301 cacggacgac ggcacggtgc tggtgccgcc cgtggagtac gaccccgtca ccgcgaacga
     6361 gctgcgcgac ctggtcgagg tggcccccac cggcaccgtc accacctggg cctggaaccc
     6421 ttccccgcgc cgtgaccagc cgctggacac cccgttcgcc tgggtgctgg tccgcctgga
     6481 cggcgcctcc accgcactcc tgcacgccct cgacgccccc gggcccgaga gcgtccgcac
     6541 cggcatgcgc gtccgcgtcc gctgggccgc cacgcgcacc ggggcgatca ccgacatcgc
     6601 ctgcttcgaa ccgtacgagg gcgcagcggc cggcggcgaa ccggcaccgc acacagggga
     6661 gttcgccgac cccgtcaccg gcatcgtcgc cccggcccgc ctcgactaca cccacacacc
     6721 gggccgcgcc cagagcgcct acctggccgc cctcgaaggc cgccgcaccg tcggcgaacg
     6781 ctgccccgcc tgccgcaagg tctacgtacc gccgcgcgga gcctgcccca cctgcggagt
     6841 cgccaccgcc gaacaggtcg aggtcgggcc gcgcggcacg gtcaccacgt tctgcatcgt
     6901 caacatcaag gcgaagaacc tcgacatcga agtcccgtac gtctacgccc acatcgccct
     6961 cgacggcgcc gacctcgccc tgcacggacg catcgccggc atcccgtacg accaggtgcg
     7021 catgggcctg cgcgtcgaac ccgtctgggt ggacggcgtc cggcaccccg accactaccg
     7081 gcccaccggc gagcccgacg ccgactacga cacgtacaag gagctggtgt agatgcggga
     7141 cgtcgccatc gtcgccttcg cccagagcgc ccaccggcgg cgcaccgacg aactctccga
     7201 ggtggacctg ctgatgcccg tcctccacga ggtcctgggc gccaccggcc tcagggccaa
     7261 cgagatcggg ttcacctgct ccggctcggc cgactacctc gccggacgtg ccttctcctt
     7321 caccatggcg ctcgacggcg tcggcgccca cccgcccatc tccgagtcgc acgtcgagat
     7381 ggacggggcg tgggcgctgt acgaggcgtg ggtgaagatc atgaccggcg aggcggacac
     7441 cgcgctcgtc tactcctacg gcaagtcctc gcccggccgg gtccgcgacg tcctcacccg
     7501 gcagctcgac ccctactacc tcgcccccct ctggccggac tccgtcgcgc tcgccgccct
     7561 ccaggcccag gcgctcatcg acgccggcga caccgacgaa cccgccctcg cccggatcgc
     7621 cgcccgcaac cgcgccgccg ccgtcgacaa cccgtacgcc cagctcaccg gcgacgtccc
     7681 cgccggcgac cacctggtgc ggccgctgcg caccggcgac tgcccgcccg tcggggacgg
     7741 ggccgccgcc gtgatcctcg ccgccggcga caccgcccgc gccctgtgcg cgcggcccgc
     7801 ctggatccgc ggcatcgacc accgcatcga ggcccacgcc ctcggcgtac gcgacctgac
     7861 cgactccccg tccacccggc tggccgccga acgtgccgga gccttcgaac ggccggtcga
     7921 caccgccgag gtgcacgccc ccttcacctc gcaggaagtc gtgctgcgca aggcgctgcg
     7981 gctgggcgac gaggtccgcg tcaacccctc cggcggcgcc ctcgccgcca acccgatcat
     8041 ggccgccggg ctcatcaggc tcggggaggc cgccgcccgc gtccaccgcg gcgagtccga
     8101 ccgggcgctc gcccacgcca cctcgggacc ctgcctgcaa cagaacctgg tcgccgtcct
     8161 ggaaggggag agcgctcatg cgtaaggagc ccgtcgcggt cgtcggcgtc ggccagacca
     8221 agcacgtcgc cgcccggcac gacgtgtcca tcgccggact ggtccgcgag gccgccgtcc
     8281 gcgcgctgga ggacgcgggg ctggcctgga gcgacatcga cgccgtcgtg atcggcaagg
     8341 cccccgactt cttcgagggc gtcatgatgc cggagctcta cctggccgac gccctcggag
     8401 ccgtcggcaa acccatgctc cgcgtccaca cggcgggctc ggtcggcgga tcgaccgcgc
     8461 tggtcgccgc caacctcgtc gccgcccgcg tgcaccgcac cgtgctcacc ctcgccttcg
     8521 agaagcagtc cgagtccaac gccatgtggg gtctctcgct gcccgtcccc ttccagcagc
     8581 cgctgctggc cggcgcgggc ggcttcttcg ccccgcacgt gcgcgcgtac atgcggcgga
     8641 ccggggcccc cgacacggtc ggctcgctcg tggcgtacaa ggaccgccgc aacgcgctga
     8701 agaacccgta cgcacacctc cacgaccacg gcatcaccct ggaacaggtc cagagctcgc
     8761 ccatgctctg ggacccggtc cgctactccg agacctgccc gtcctccgac ggcgcctgcg
     8821 ccatggtcct caccgaccgc gacggcgcca cacgctcgcc ccacccgccc gcctgggtgc
     8881 acggcggggc gatgcgcagc gaaccgaccc tgttcgccgg caaggacttc gtctcaccga
     8941 gggccggccg ggactgcgcc gccgacgtct accgccaggc gggcatcacc gacccgcgca
     9001 gggagatcga cgccgtcgag atgtacgtgc cgttctcctg gtacgagccg atgtggttgg
     9061 agaacctcgg cttcgcggac gagggcgagg gctggaagct caccgaggcg ggcgtcaccg
     9121 aactcgacgg cgaccttccc gtcaacccgt cgggcggcgt cctgtccacc aaccccatcg
     9181 gagcctccgg catgatccgc ttcgccgagg cggccctcca ggtacggggc cgggcggggg
     9241 agcaccaggt cgacggggcg gcccgagcgc tcggccacgc ctacggcggg ggcgcgcagt
     9301 tcttcgccat gtggctggtg ggatcccagc ccccgcccgg ctgaggagag gcggcgggcc
     9361 cggctccgga gggccgggcc cggctccacg acgtgagccg ggacacgtac catgggcggc
     9421 atgtccttcc tccgccgccg tagcgccgca acacccgcgg gcccggactt cgacgtcctg
     9481 gccatggacc ccggggactg gcccggcaac ctcggcgccg gtctgctccc cgcccccgac
     9541 ggcagctgcc agggcgtctt cctccggtac gacctgtacg gcggccgggg cccggcgatg
     9601 atcatcggca acctcccgga gggctcgccc gcccgcgaga ccgaggaggg ccaggtcccc
     9661 ttcgaggtgg cccagctgct gctcgccctg gagaacgacg agccgatcga ggtcgtcagc
     9721 accgaggacg tccccgtcat gcagggcgac aacctgctga tcgtccgtcg cgtcaagctc
     9781 tccgagagcc gtatctcctg cgtccagttc gaccgcagcg acggcgtcct cgtgaccatc
     9841 gccagctggg accggccgat caccgacgac ctgtacaccc tgctcaagcc gctgcccgcg
     9901 gagctcttcc agcagggctg acacctccgc gcccgaggcc gcccggaccc ctccgggcgg
     9961 cctcacgcac accgtggcag cggcaggcgt cgcggcccgg tcaggatccg ccggacgcgc
    10021 ccgaggccgt accgaccgtc tcccggacca tcagccgggt cacctgcgcc gccgacgtac
    10081 cgagccccac cggcccgccg aggtgccacg gcgcaccgtg gacccggcgc aggtcctcct
    10141 cgcggtagcg gcggcatccc cggtgccaga tcaggatgcc cgcgagccag tgctccagct
    10201 cccgcacata gcccgccagc acctcccgcg cctcggcatc caggtcgaag tcgtcgtaca
    10261 gcgcgggcag ttcgacgtcg gcgacatgac ggaactggcg cagccgcgag ttcatcaggt
    10321 cgtgcacgat cgccacgccc gtcggatagt cgacgccgaa gaagttctgc acgaccaggg
    10381 cgccgttgtg cacctcgccc tcgtactcga tctccttctg gtacgagaac aggtcgttga
    10441 gcaggcacgc gtagtccgcg gccgcgttct ccagggaccg cagggggccg ctgcggtaga
    10501 cctcctcggg aacccgcttg ccgtgtccga gccggcacag gctcatcgtc aggtccgagc
    10561 cgaacgtcgc ccgccgcatc tccacgtagt cgaccgggtc ggggacgcgg ttctgagcct
    10621 ggttggacag ctcccacagc cagctcgcgg tcatggtctc gatcgcggta cggaaggcgc
    10681 gccgcgcacc cgcgtccatc gggcccgccg tcctgtccca gagatcgccg aggctccgct
    10741 ccagggcgtt caccggctcc ggcgtcccct cgccgtccag cggcatgaac agcgacaacc
    10801 gctcgttcgc gagccgcgcc cccgccaggt ccctggtgcg tccgtgcacc accgggaacc
    10861 agtcgtcccc gtacgtcccc caggccagcc acgccgagga caggtccagc ccgtccggcg
    10921 tcgcgtccgg atggatgccc gccgcgcaca gcggcaggtc gatcgcgcgg atccggtcct
    10981 cgtcccagat gtgcgaaccc gggacgcccg gctgcgcctg gaggatgccc atccgccgcg
    11041 cccagtcgac gacccggacg cgggccccct ccaggtgggg gctgagcgtg gtggtgtagg
    11101 gcaggtcgaa gtccgggagg atcgagggac ccacatgccg gtacggcaca tggctgtggc
    11161 tgcgggcccg cgcggtctcc gagcggaggg tgaaccgcag cgaggcggcg gacatgccga
    11221 agccgggcac ggcctcgccc gcgccgccgc cgttcatgta gcggctggag cgcatgtgcc
    11281 actcatgccc gccggactgc cagtcctgga gccccttggc gtacgccagc acggccgcgg
    11341 tctcctccgg gcccagcctc ttctcggcgc agagcgggcc gagctcggtg agaacggtgt
    11401 tctcgaactg ctggagccgt gaggtcagca ggtcgttgac ggcttcggcg gcctcctgcg
    11461 tggagcagcc gaggaaggtc tccagcacca gcacgccgtt gctgttctcc ccctcgtcct
    11521 ccacctcccg ctggtaggag aagaggtcgt tgcgcaggtg caccgcgtcg gagaaggcgt
    11581 cccgcaggac ccgcagcggc cgggacgcgg cgacccggtc cggcacctcg gccccggccg
    11641 cgtactccac cagacccgcc gaccaaggcg cgccgcccac cttccggcgc atctcgatgt
    11701 actcgaccgg gttggcgatg cggccctcgt ggatgttgga cagctcccag agggactcgt
    11761 tgaggaggtt ctccgtggac tccgcgaacc gggcccgcca gccgtccgtc atcgcgggga
    11821 tcgtccgggt ccacagatcg gcgagccccg cctccacggg gttctccggc tccgggagcg
    11881 cagccccgcg ctccatcggc atgaaggccg gcagccggtc caggtaccgc ttggcgccct
    11941 cgcggtcggg cgtgcgcttg aacagttcca gaaagtggtc gtcgaagaag aagacccaca
    12001 cgtaccagtc ggtgaccagg ctcagcgcct cggccgagca gtcgggatgg gtgtacgcgc
    12061 acaggagggc gtagtcgtgc gcctccaggt ccttctcctc ccagataccg gacccctcca
    12121 gcattcccat ggagcgggcc cactcccggg tgtgcgtgcg cgccgtctcc aggtgcgggt
    12181 tgagccgggc cggatacggg acgtagaagt ccggcagtga gaagggctgt gccatgtgcg
    12241 tcgggccttt ccagaagcct ccgcgcgcgg gaacgcgcgg aacggtggtg tccgcgcagc
    12301 actacccttc ggccatacgg agcacgcacg gcggcgatta gtcacatgat cgctctgcga
    12361 cggcgcgtgc tcggaaggcg gtcggcgggg gccgccggga gcggcccgcg gtggctcagt
    12421 aggccgagtc gacgttgtcg atcgagccgt accggtcggc ggcgtagttc gcggcggccg
    12481 tgatgttggc gaccgggtcg gtcagcttct tcggggtgcc cttgacgtgg taggcgtcga
    12541 aggtgggctg gatgacctgg aggagtccct tggaggggat gccgttgcgc gcgttgatgt
    12601 cccagtcgtt gacggcgttc gggttgccgc tggactcgcg catgatgttg cggtgcagtc
    12661 cctcgtagga accagggatg ttcttcttct tcatgatgtc gagcgactcg cggatccagc
    12721 cgtcgaggtt gttcgagaac ttcttcggcg tgacggcctt gcgctcggtg gagcggttgg
    12781 cggcctgctt gtcggagcgc gcctcggcgg ccttgtgggc ggccgcgcgg tcggcggcct
    12841 tcttcgcggc ggcgctctcg gcggccttct gctccgcggc cttctcggcg gcgtccttcg
    12901 cggtggggat gcccgccgcg gcgaccggct ccacggatac ggaggaccgg gcggcggagg
    12961 tctgcgcctc gctcgtgccg ccggtggcgg ctatggcggt gaccgagccg gccgcgacga
    13021 gtacggcggc ggcgatctgg tgcgagcggg tgatgcgcag ggtggagatg cggggcatgc
    13081 gtgagctctt cctatggggg acgggcttgg cggccttcgc gccgcgtcgg ccgcaaccgg
    13141 tccgtacggg ccgcgtccgc cgatgggcga tcgctgaggg ctcgtactcg gtgcttgccg
    13201 gaatccatgg ttagcgggca ccggcatagg aagcaatgac cgtcattact atctttcatc
    13261 gtgatatgtc caattcatgg gccaaaagga tggttcatta cgccgggtgg gggcacagat
    13321 ggccactatc cgcagtcgta ggtgacgtgg gtctcgtggc gggcctcacc cgtgggggac
    13381 cccggaacgg cacagggtca gcacgcggtc accgaacgca cgacagcgcg ccgcgaggtc
    13441 cggtgtgtcg gcaccggtcc ccgcagcgcg ctgcgtcctc acagtggtca ggtcactgtg
    13501 gtcctcgtcg aggggtgcgg gcccacggcc cgcacccctc tcccgcctcg gccctcggcg
    13561 gcctcgccca tccgctcgta caccccgcct cagcgggtgc cgaccgccgc ccgcaccgcc
    13621 cgccgcgcca tcgcgcagtc gtcgtggagc ctgcgcagca gcagccgctg ctcctcgccc
    13681 gaggagagca ggccggggcg ctcggacccg gcggccaccg ggggggcctc acgcatggtg
    13741 cgctggaccg ccgtctcgta gttgcggatc tcgcgggtca gcaccagcat caggttcacc
    13801 aggaacgcgt cccgcgcggc cggccccctg gcctgggcca gctgactgat ctggcgccgc
    13861 gccaccgggg cgtcacccag caccgcccac agcgtcgcca ggtcgtagcc ggggaggtac
    13921 cagcccgcgt gctcccagtc cacgaggacg ggaccggtcg gcgacagcag gatgttggag
    13981 agcagcgcgt ccccgtggca gaactgcccc atcccctgtc ggccgctcgc ctgggccagg
    14041 ccgtgcagca gcttctgcag gtcgtcgaag tcgcggtcgg tgaacagccc cagctcgtgg
    14101 taacgcgtga tccgcgaggc gtagtcgagc ggcgcctcga acaggccggg cggcggccgc
    14161 caggcgttca cccggctgat cgcgcccagc gcggcacgga tgtcggcccg cggcggcgcc
    14221 tccgccggat gccgggtgag ggcggcgacc cggccgggca tccgctcgat caccagcgtg
    14281 cagttctccg ggtccgccgc gatcagccgg ggcgcccgca cgggggggcg gtgccggacg
    14341 aacgcgcggt acgccgctat ctcgtgccgg aaccgctcgg tccacgccgg cgagtggtcc
    14401 agtaaacact tcgccacggc ggtggcccgc ccggtcgtgc cgacgatcag gaccgagcgg
    14461 ccgctgcgcc gcagcacctg gaccgggttg aactcggggc agacgcgctg cacggaggcg
    14521 atcgccatcc gcacctgcgc gccctgcggc ccggacaggt cgatccttcc gctgagcggt
    14581 ccggcgcccg gtcccggggc ccgtcgggcc cggcccggac cctgcgccgg tgcgccggcg
    14641 tgaggagcca gatagggccc ggcgctcgcg cccatcgggc ggagcggtcg gggcggggcg
    14701 gacacggagg acgatgctgt gtacatgggc gagacagatc ccttcgtgcg ccgacaaggt
    14761 acgtgcgcca acccggccga cggccggtcg gcaccctggg gagtaccgag ggctgccggg
    14821 cggggtggcg cactcctacc tgacaacgga tgacgggtgg cagaccatct ggcggaccct
    14881 ggcgaaccct ggcgaatagt caccgagcat ctgaccaggg gttagtgtca agtcagccga
    14941 gaacctgggg gcttgacgtg accggagaac ccaacacccg cttttctgac ctgttcggcc
    15001 tggccggctg gtccaagggc gaactcgcga gactggtgaa ccggcaggcg gcggccatgg
    15061 gccacccgca gctggccacc gacacctcgc gcgtcaggcg ctggatcgac atgggggagt
    15121 ccccccgcga tcccgtgccc gaagtgctgg cggctctgtt caccgagcgg ctcggccgtg
    15181 tcgtgaccat cgaggacctc gggttcggcc gacgcgggcg tgtggggaaa cggcgtgact
    15241 ccgggacgga cgacgatccg gatcgactgc cgtgggcgcc cgaacggacg gcagcggttc
    15301 tcaccgaatt cacgggaatg gacctcatgc tcaaccgacg cggcttggtg agtgcgggcg
    15361 ccgcgctcac cgccggatca accatcgccg gccccatgta cgaatggctt cgcaacgccc
    15421 ccgctccggc ggccgaagca ccacgcgcca acacgcccgc gcacgccgat cccgccggtt
    15481 tcgaccggta cgaggcggcg ccggtcggct ccgaggagat cgaggccctg gagtactccg
    15541 tcgaggtgtt ccgtcgctgg gacgcctccc ggggcggcgg gctgcagcgc aaggccgtcg
    15601 tgggccagct caacgaggtg ggcggcatgc tggcctaccg ccaccccgat catctccagc
    15661 gccgcctgtg gggcgtcgcc gccaacctcg ccgtcctcgc gggctggatg tcccacgacg
    15721 tcggcctcga acccaccgcc cagaagtact tcgtcatcgc cgcccacgcg gcgcgcgagg
    15781 gaggcgaccg gccgcgcgcc ggagaggcgc tctcccgcgc ggcacgccag atggtgcacc
    15841 tgggccggcc ggacgacgcg ctggacctga tgaagctcgc caagtccggc tcgggcgacg
    15901 agaccctgcc ccgcacccag gcgatgctgc gcaccatcga ggcgtgggcg caggcgtcca
    15961 tgggccgggg gcaggcgatg cggcggaccc tcggagaggc cgaggaactc ttcacctcgg
    16021 acaagggcga tgtgcccgcc cccagttgga tgcagatgtt cgacgaggcg gacctgcacg
    16081 gcatgcaggc gctcgccttc cgcacgctgg ccgagcacga ccgcagcgcc gcggtcatcg
    16141 cccagcgcca cgccaagcag gccctggaac tgcgggacgg cgaccgtcgg cggtcgaaga
    16201 tcttcgacta catctcgctc gcctcggcct gcttcatcgc caacgacccc gaacaggccg
    16261 accgctacgc ccggctcgcg ctggtgtcga tgggggagac ctcctcccac cgcacctggg
    16321 accggctccg cgagatgtac cggctcaccg gccagttcgc cgggcacacc ggcgtccagg
    16381 acctgcgcgc ggagatcgaa cacgtgatgc cgccggccgg gaagaagtcc gggggcgccg
    16441 agacctgacc cggcgccccc ggacttcttc cctcacatcg agccgcttac gcgctccctc
    16501 acgccccgac gcgggcgacc agcacacacg cgtcgtcctg gcgttcggcc ccgccgaaga
    16561 cctcgacgac gctccggacg cactcctgtg ccgtacgggc ccgtgcgaac cggggggcga
    16621 gggcgagcag cgcctccggg cccgcacccc gggtgtcgtg ccgcatcagg ccggcggtgt
    16681 gcaggacgag cacgtcaccg gggaagagcc gtacctcgtc ctgctcgtac gggacgtggg
    16741 acgcggcgcc gagcagcacg ccgtccggcg gcggcagcgg ccgtcccgaa ctgtggcgga
    16801 agagcagggg agcggggtga ccggcctgcg cccaggagag aagggaggtc gcggggtcga
    16861 agcgacagca cagggcactg ccgagcgtcg gctgcaccga cgtctccagc acctggttca
    16921 ggtgccccat cagggggccc ggttcgatgc cggcgacggc catgccgcgc agcgccccca
    16981 gcatcatcgc catggacgag gtggcgggga cgccgctccc ggtgaggtcg ccgacggtga
    17041 gcagggtgcg tccgtccggg agctccatcg cgtcgtacca gtcgccgccg atgagcccgc
    17101 ccggcccgga ccggaggtag tgcgcggcga cgtcgagggc gcccggtccc tgccggggga
    17161 ggggcggtga tccgcgccag gggggcagga cgctctcctg gagttccacg gccatgcggt
    17221 gttcggtgcg ctcaccgtgg tccgcgcggc gcaccgccgc accggtgcgc cgtacggagg
    17281 gctcgtcgcg ccgccgctcg gtgacgtccc gcagcaccgc ccacatcgag gcggtgcagc
    17341 cgtcggcgtc gaggaccggc tcacccgtca tgtgcagggt gcgggtgcgg ccgtcggcgc
    17401 gcacgatgcg gaactccccg tccatcgccc ggccgtcgac gaggcagccg gtgaccatgg
    17461 cggtcagcag cggctggtcc tcgggcagca ggacggacgg cagatcgtcg agggacaggg
    17521 gcgcggaccc gggcggcctg ccgaagatct cgtacaactc gtccgaccag gcgcactcgt
    17581 cggtgaggag gttccactcg gcgctgccca cgccgtacga cggggtgccg cggcccgggg
    17641 cctccggagc cgtgccgtcc tcggcctccc gcccctcggt gtcctgcccg gtcagccccg
    17701 atctcagccg gcccaggttc tcgtccagac cgtccaggta ctgcacggcc agctcgtaca
    17761 gggcgcgctg ccggcgccga ccggcgtcgt cctcgtcgaa cagaagggcg tcgcgccgta
    17821 cggcgtcgac atcgccgcgc agccgccgtg tgcgctggat cagggcgttg acggcgtcac
    17881 gcgcgggagg tcgtggtgcg gggcggtccg cgaagagggg ggacggcatc tcgtactccg
    17941 atacaggcgc ggcctagccg gttccgacag gtgggccggt accgactttg gcacagcgcg
    18001 cgacggaccg taagggattc ggcgacactc ggggcgatgt tgcttctggc atatgccagc
    18061 ggccctcgat cggcattatt ttccgaacag gcttacgtat gcggcgagtt gaccgacgtc
    18121 cggagagcgt gcgggatcgg gaatgccgag cgcggaggcc gtgttacccc accagaacga
    18181 aaacgaatcc catccccatc atgggggcgg ggtcgtgcga gacatcggga ggcgcccatg
    18241 gcacgcagcg agaccaggcc cgtcgtcacc ctccggtcca ccgccgggac gggccgcagc
    18301 tatgtgacac gcaagaaccg ccgcaacgac cccgaccggc tggagctccg caagttcgac
    18361 tccgccgccg gccggcacgt cctgttccgt gaggtccgct gaccacacgg agaagtccca
    18421 cccctccgat cgacgcgcca ccgtcggccg accggcccgc ggcgaggaag gaacccatcc
    18481 atgaagcctc gtatccaccc cctgtcccgc cccgtggtct tccgcgaccg cgccgccggc
    18541 accgctttcc tgacccgctc gaccgccgat tccggcgagc gcgtggtgtg ggaggacggc
    18601 gacagctacc ccgtcatcga cgtggagacc tcctcggcga gccacccgtt ctacaccggc
    18661 ggccgccagg tgctcgacgt ggcgggccgc gtggagcggt tccaccgccg ctacggcgac
    18721 ggcggtccgt ccgccggttg accggacggg ttctggccgg ggagcggccc cggggcgcgc
    18781 gtgctgtgga tcacagcgac cgcgtttccg ggaacactcc cgagtggttt atcgttcatc
    18841 tatatgtggg agtgaggggg acggtgtccc cgggcctcac ctccggcccg tcgggaagac
    18901 cgcaccgccg gaaccccgtg gagcaccccg ccgagaggcg accgcccctt gcgcccgcat
    18961 cagagccgcc ccggctggat tcccccgatc cggccggggc ttcccctgtt ccgcgccccg
    19021 gggcgtgccc ggcggatcag gatcggacag gccggacacg ccctgaggct gtcccgaccc
    19081 gcgcgaagcg ccccacggcc ggaggcctca cacggtctcg tcgagatcct tcgcgtagtg
    19141 ctcgatcgcc cgccggtagc gctggacgta cgggtcctga ctggtcgccg ccgtcacctc
    19201 cagcagcagc cgcatcgcct catggtgctc gtccgtgttg aacagggcca tcgccaggaa
    19261 cgtccgcagt gcgccgtcgt ccgggaactc ctcgacgccc cggcgcaacg tctcgaccgc
    19321 ctgcccgtac ctgcccagga cccggtacgt gctgcccagc cccagaagcg ccccgcgccg
    19381 gtcctccgcc ccgagccccg ggttgcccag agcgcgctcg tagtacggca ccgcctccga
    19441 ctccaggccg agggtgtcgt ggacccacgc cgttcggtag gccacctcgg cgtcgtccgg
    19501 aagcgccgcg gtgagggcga gcagccgctc gcgcgcctcc tcgggccggc cgtcttcgcg
    19561 caaccggtcg gcctccgcca gcaggtcccg cttcttgtcg tcactcatct gcccatcggt
    19621 actcatgcgc acatcgtcgc aggcggggac agaggggcgg acgagtttcc gctccacggg
    19681 ccggccgggg tgtgttccgg ccgggcgggg gcatccgtcg cccatgacag cagaggtgaa
    19741 tccccctgta cgccagggga catgggtacg agtactggtg cgcggggcgg tcctggtcgt
    19801 ggcactgctg ggtctggtgg cgttctccgt cctgctggcc aaggtgacgc tcaccccgtc
    19861 gccggcctcc gaggacctgg tcacctcgaa cctccggccc gggaggtcgc tgcgccagta
    19921 cgccgaggac tacaccttcc tcgccgcgtg caagcaggcg ggcggaaatc tgctcctggg
    19981 cgtcccgttc gggctcctgc tgccgttctt cgtacagcgc cggctgcgga tgatccgtac
    20041 gacgctgctc gcggcggtcg tcatgaccgt cgtcgaactg atccaggggg ccctcgtcac
    20101 gggccgcgcc ttcgacatcg acgacgtaat cctcaacacg acgggcgcgg tgctcgggta
    20161 cttcctgctc ggccgccgca tcagccaccg ctactacgtc tacaccgacg acaccgccgt
    20221 ccccgacacg tccgcgaagc cgaaggccga gcgtgacgcc gggacggagc gggaaaccga
    20281 ccggccggcc gggcgccgga ttcctccgaa gccgagcgcc gggccggagc acacgccggc
    20341 gaccgcccgc acccggaccg gaccgctggc ccggctgagg cccgcgccca aggatcaggg
    20401 accggcaccg gccgggcagc gcccctcccg ggtccgcggg accggcggcc cgcagggcgg
    20461 caccgccccc gcgccgagca agagcccccg tgctctgctc gaccgcttcc gccgccactg
    20521 agcggactcc cggggcggcg gccccaccga accggcccgc aggcggcccg gcacccgttc
    20581 gggccgggcc gtttgcgggc ggcggggccc ggccgcacgg tggggacacg ccgtgcgccc
    20641 ggacgggcgt acggagcccc tgccgaggag gagcgccatg gccgaacccg aaggccgatg
    20701 gagcccgggc cgcacggagg cggacgccga cgagttccgg cccgtcctgg agatcgtcca
    20761 accggcacgg cagcggcggc tgaccgtgct cctgcgactc ctgctgctga tcccgcactt
    20821 catcgtgctg ttcgtcctgc acatcgccgc tttcttcacc gtgatcgtcg gctggttcgc
    20881 ggccctggtc ctgggcaggc tgccggaccc cgtcttccgc ttcctgagcg gcgtcctcgg
    20941 ctacgacatg cgcgtctcgg ccagcgacat gctgctcatc gaccgctacc cgcccttcgc
    21001 gctgaccccg cccgccgact acccggcgcg gatcgaggtg cgccccacgc cgctcaaccg
    21061 gctcgcggtg ctcttccgcg tcttcctgat gatcccggcg gcgatcgtgc agagcctcgc
    21121 cgtgtacggc tggtgggcgc tcgccttcgt ctggtggctg atcacactgg tcctcggccg
    21181 catgccccgg ccgctgttcg aggcgacgac cgccaccctg cgctaccgga tgcggttcac
    21241 cgcgtacgtc atgatgctca ctcccgccta ccccaagggc ctgttcggcg acgacgcgtt
    21301 cgccggagcc acgcgggccc cgcacccggg cgcccggccg ctggtcctga gcagcgccgc
    21361 caagtggctc gtggtgctct tcctggtgct cggcctcgcg ggacacgtca cgtcgtccgt
    21421 gaccgcctcg acgaccgacg acacccccgc cacccgtctc ctcgggccct gagcacgtgg
    21481 cgactcctca cggcgcctcc gacgccgcgg ccgcgtagcg ccgggcgagc cgggcgaagg
    21541 cgtcccggag ctcggcgggt ccgacgacct cgatgtccac gtcgaaccgg ccgagatccg
    21601 cggccagccc cgcccaggac caggccccca gaaccacccg gcagcgcccc ggtccgtcct
    21661 cctcgacgat cccgtcgcga acgtgcaccg ccacctcgcc ggccggggcg tcgaggatca
    21721 cctcgccccg gcacggccac gcgccgggcc cctcggagcc ctggaagcgg gcggcgacga
    21781 aggcggccac atcgccgccc ggcacctcac gcggcgggaa gcggggaccc gtgggagtac
    21841 gcggctcgat ccggtccgcg cggaagatgc gccagtcctc ccggtccagg tcccaggcga
    21901 cgagatacca gcgcccgccc caggtcacca ggcggtgcgg ctccacccgt cgcaccgggg
    21961 gcgcgtcccc gccgtccccg gccgccgggg cgtacgcggg ggagtagccg aaacgcagca
    22021 cctcgcccgc gtgcacggcc gagctgaggg ccagcagcac gcgcgggtcg gcctgcggcc
    22081 gaggcggaac tccggtgcgc tcgacggcgg tgatccgcaa cgcgtccacc cggtggcgca
    22141 accgggcggg catcacctgc cggactgtgg tgagcgcgcg ggccgccgac tccccgatcc
    22201 ccgccccggt ggcggcggcg gtccgcaggg cgacc
//
