LOCUS       NZ_CP070260            10426 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces californicus strain FDAARGOS_1210 chromosome.
ACCESSION   NZ_CP070260
VERSION     NZ_CP070260.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces californicus
  ORGANISM  Streptomyces californicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7919564)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T., Yan,Y.
            and Sichtig,H.
  TITLE     FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
            Supporting development and validation of Infectious Disease Dx tests
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7919564)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T., Yan,Y.
            and Sichtig,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2021) Institute for Genome Sciences, University of
            Maryland School of Medicine, BioPark II, 801 W. Baltimore St., Suite
            619, Baltimore, MD 21201, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT v. 8.0.0, HGAP v. 4
            Genome Coverage                   :: 624.55x
            Sequencing Technology             :: Pacbio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016906265.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 09:02:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,240
            CDSs (total)                      :: 7,147
            Genes (coding)                    :: 7,032
            CDSs (with protein)               :: 7,032
            Genes (RNA)                       :: 93
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 115
            CDSs (without protein)            :: 115
            Pseudo Genes (ambiguous residues) :: 0 of 115
            Pseudo Genes (frameshifted)       :: 36 of 115
            Pseudo Genes (incomplete)         :: 97 of 115
            Pseudo Genes (internal stop)      :: 12 of 115
            Pseudo Genes (multiple problems)  :: 27 of 115
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:25:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2873770
            Orig. end                         :: 2884196
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070260.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10426
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="18"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10426
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10426
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5426](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5426
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            complement(634..1968)
                     /gene="lysA"
                     /locus_tag="I6J40_RS12295"
                     /old_locus_tag="I6J40_12285"
     CDS             complement(634..1968)
                     /EC_number="4.1.1.20"
                     /GO_function="GO:0008836 - diaminopimelate decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /gene="lysA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_DAP_Arg_deC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264: diaminopimelate decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010058601.1"
                     /locus_tag="I6J40_RS12295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_12285"
                     /product="diaminopimelate decarboxylase"
                     /protein_id="WP_030192841.1"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 6e-63, bitscore:
                     211.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 3.3e-17,
                     bitscore: 61.2, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELLPTRLPTAPDDLSVWPASTARLPHGHLSVGGVSLAETADRF
                     DTPAYVVDEDEIRTRCRTYRAAFPAADVLYAAKAFLCRAMVRWIDEEGLGLDVCSAGEL
                     DLAHAAGFPPERMVLHGNAKSPRDLATALRLGVGRIVVDSPSEIARIAALTGPARRQKV
                     MVRVVPGVAAGGHEKIRTGTEDQKFGLSLTDGSAQHAIARVLGQSSLELTGLHCHIGSQ
                     ITDVKPYLVAVRRMVGLMARVHESHGVTLPELDLGGGHGVAHRPGEPALDPTALARRLT
                     AELAESCAVAGLPVPRLVIEPGRAIAAPAGVALYRVLAVKHTGRTLFVAVDGGMSDNPR
                     PALYGARYAPRLVGRVPTAGPVAATVVGRHCEAGDVLAADVPLPGDVRPGDLLAVPVAG
                     AYQVSMASAYNLVGRPPVVAVHGGTARLLIRRETQEDLRRRDVGA"
     gene            complement(2006..>2290)
                     /locus_tag="I6J40_RS12300"
                     /old_locus_tag="I6J40_12290"
                     /pseudo=""
     CDS             complement(2006..>2290)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015575631.1"
                     /locus_tag="I6J40_RS12300"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_12290"
                     /product="SAV_915 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GLLFVPVRATDAGPVLRMFRTPLGERTAVGFTARGLLTATLGAGH
                     AAIRLAEPALRLLVEPLGVDRVVVDPALSAPAVTRALAGDDLLPTRVVR"
     misc_feature    complement(2594..2614)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.22"
                     /tool="antismash"
     misc_feature    2640..2655
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            complement(2950..3540)
                     /locus_tag="I6J40_RS12305"
                     /old_locus_tag="I6J40_12295"
     CDS             complement(2950..3540)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966811.1"
                     /locus_tag="I6J40_RS12305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_12295"
                     /product="hypothetical protein"
                     /protein_id="WP_030192837.1"
                     /transl_table=11
                     /translation="MSLLELIERADERTLAAAAVACLDRCLPLLAGAGTEPLRPLWASC
                     EEGRDWANRLASVRRELDADAGAVPGADDPAALVRASLATAPSDFAAPALREWADLCSL
                     VALRVHGRFDAPDGGRAEDGDDLVEAARTGEPAALGPLVAGELERQVRILEILAETSGT
                     TGSGAGLRKALDLSTEGRRVLRAVMSRRARVRG"
     misc_feature    complement(3574..3588)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.61"
                     /tool="antismash"
     gene            complement(3590..4414)
                     /locus_tag="I6J40_RS12310"
                     /old_locus_tag="I6J40_12300"
     CDS             complement(3590..4414)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018510460.1"
                     /locus_tag="I6J40_RS12310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_12300"
                     /product="DUF4328 domain-containing protein"
                     /protein_id="WP_030192835.1"
                     /transl_table=11
                     /translation="MLCTRCRTRTAVTADDLCTFCSGTRPPLPGGLMAPVPGPGGWTAG
                     AWPRSPVALARAVTVLLGVVIAADVFAVVTGLRVRSRWGALAEGGSPDVHMRAAQIAER
                     YFVLAALVQGTALVVTAIVFVVWFHRTRRNAEVFHAGVQRLGPGWAIGGWFVPIANLWI
                     PYRVASGVWEASAQTGPGDGWRTVPKTPLKLWWGAWVLSLLATRVAEKIWSRAFEPEEV
                     ARAAGLVVASDALDIVAAVLAILFVRALTRMQVERAARAVNSVPAVSDAPLT"
     misc_feature    4702..4717
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.75"
                     /tool="antismash"
     misc_feature    4838..4853
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     misc_feature    4981..4999
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.88"
                     /tool="antismash"
     gene            5001..5426
                     /locus_tag="I6J40_RS12315"
                     /old_locus_tag="I6J40_12305"
     CDS             5001..5426
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966560.1"
                     /locus_tag="I6J40_RS12315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_12305"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_030192833.1"
                     /sec_met_domain="melC (E-value: 2e-37, bitscore: 127.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRPTRRQVIGVATGAAASIALVGTAATSPGAASAAPGKTEAPAL
                     GPAPFDEVFQGRRIQGAPAAADAHAHGQAHAQGHAGHDAVYRVWIDGRELHVMQHGSSG
                     WSSAINHYERFATPLDTARTAVASLKGAHVVPFDHTA"
     gene            5443..6267
                     /locus_tag="I6J40_RS12320"
                     /old_locus_tag="I6J40_12310"
     CDS             5443..6267
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379204.1"
                     /locus_tag="I6J40_RS12320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_12310"
                     /product="tyrosinase family protein"
                     /protein_id="WP_030192831.1"
                     /transl_table=11
                     /translation="MTVRKNQADLTASEKRAFVAAVLGMKRKGVYDEFVSTHRTRFATD
                     MNTGVYVGHFGPSFLPWHRKFLIDFERELQKFDPSVSIPYWDWTADDTVASSLWAPDFL
                     GGTGRPLDDQVMDGPFAYSAGDWRINVQVDSRAFLARNLGHRVSTLPTRAEVDSALAIP
                     TYDSAPFRDGSAGFRSALEGSAGYMSMHNRVHTWVWGQMESSVSPNDPVFWLHHAFVDK
                     LWADWQALHPTAAKYLPAGGTADVIDLNETMPPFPATTPQDMLDHTPFYTYA"
     gene            complement(6381..7988)
                     /locus_tag="I6J40_RS12325"
                     /old_locus_tag="I6J40_12315"
     CDS             complement(6381..7988)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761481.1"
                     /locus_tag="I6J40_RS12325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_12315"
                     /product="family 20 glycosylhydrolase"
                     /protein_id="WP_030192828.1"
                     /transl_table=11
                     /translation="MSPSRGALVTGAAVTAAAAVVLTVVVWPEGSGSGPSGDTASPSGT
                     SAEAAPSPTRSYPMSSTPSAIPAVREHTAARGPGWQPGKGSGVVIAKGSQVLADEARLL
                     ADELKIRYRGAEPAKAGDVELALGGKDAGPAESYTLTVRDRKVRITGPDESGVFYGTRT
                     LKQSLKADGAVPEGVVNDRPDRPQRGLNLDIARKHYSAEWIEDRIREMGDLKLNQLGLH
                     FSDDQAFRIESKSHPEVVSDEALTQDEVRRIVGLANSRHIEVVPEIDSPGHLGAVLAAH
                     PDLQLRNTAGVASQGSVDISKPGAAKLIDELLDEYTELFPGRYWHLGADEYQALVVQNP
                     AASYPQLQRAAEKKHGAGATIEDLATSWLNDRADVVVPKGRTAKAWNDGLFRGTKVKAD
                     ENIEIEYWTGKEYGVRPPQEYLAAGYKMLNLNDEFLYYVLGEPNDFTYPTGKRIYEQWT
                     PLVMRGTEPVAERYSKQILGGRFAVWGDLANAQTTEQVAQGIEMPLVATSQKLWDPRKP
                     ALSWAEFQELAKRTGSAG"
     misc_feature    complement(8021..8036)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.28"
                     /tool="antismash"
     misc_feature    8231..8245
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.56"
                     /tool="antismash"
     gene            8564..9031
                     /locus_tag="I6J40_RS12330"
                     /old_locus_tag="I6J40_12320"
     CDS             8564..9031
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154474.1"
                     /locus_tag="I6J40_RS12330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_12320"
                     /product="2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
                     decarboxylase"
                     /protein_id="WP_050490869.1"
                     /transl_table=11
                     /translation="MGLAHFNSLPFAAAEAAFLECCGSLRWAHRMAAHRPYPDLGALLA
                     ASDEAGYDLAPGDIAEALAAEPATCLHHDAPRAAHLALRAAHAAYESRFGHAFVICLDS
                     YAPSQHVDQVLAGIRVRLAHEVDEERAVTAEELRRLARSRIVELVTADPGR"
     misc_feature    9117..9132
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.28"
                     /tool="antismash"
     gene            9264..9644
                     /gene="sdhC"
                     /locus_tag="I6J40_RS12335"
                     /old_locus_tag="I6J40_12325"
     CDS             9264..9644
                     /GO_component="GO:0045282 - plasma membrane succinate
                     dehydrogenase complex [Evidence IEA]"
                     /GO_function="GO:0000104 - succinate dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sdhC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047903.1"
                     /locus_tag="I6J40_RS12335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_12325"
                     /product="succinate dehydrogenase, cytochrome b556 subunit"
                     /protein_id="WP_030112669.1"
                     /transl_table=11
                     /translation="MPAGTLYRGREGMWSWVAHRVTGVLIFFFLFVHVLDTALVRVSPE
                     AYDDVVATYKTWPVAFLEYGLVAAILFHALNGLRIIAVDFWAKGPRLQKQMLWTVVGIW
                     IVLMVGALYPVLGHAVRDLFGS"
     gene            9650..10132
                     /locus_tag="I6J40_RS12340"
                     /old_locus_tag="I6J40_12330"
     CDS             9650..10132
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015610867.1"
                     /locus_tag="I6J40_RS12340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_12330"
                     /product="succinate dehydrogenase hydrophobic membrane
                     anchor subunit"
                     /protein_id="WP_030112670.1"
                     /transl_table=11
                     /translation="MSSETSSAAAIGDVEGVSLYDVDHPAPVIEPPRKRTGKTPKATRG
                     NFEMYAWLFMRLSGIVLVVLVIGHLLIQLVLDGGVSKIGFAFVAGRWASPFWQVWDLLM
                     LWLAMLHGANGLRTVINDYAERDNTRFWLKMLLYTATVFTVLLGTLVIFTFDPNIR"
     misc_feature    10379..10394
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.75"
                     /tool="antismash"
ORIGIN
        1 tctccgggaa gaggagagcc aggacgagat atccgagcag ggacacggcc acgacgaggc
       61 cgacgacatt ctcgacggtc atggcttggt cacccctcgg gcgacgagag ccaccagcgc
      121 gaatatcgcg gtcgtggtgg cgacgaaggc cagatcggcc atcgcggact cctgatggat
      181 aaggggaagg gaaaggagat cggccgttcg gccaagaaga ggaaacctcg gattcacccg
      241 cgggttgagc cgccttgacg gggtccatac gaggacgggg ccgcctttga cgccggtctg
      301 acgcgggtac ggaaacgggt cctcgcgcgg ctgcgcagcg tgtccgggcg cgctcggcgt
      361 gggtacggaa acgggccctc gcacggctgc gcggcgtggt cgggcgggct cgacgcgagt
      421 acggaaacgg gccctggtac ggctgcgcag cgtggccggg cgcgctcggc acgggcacgg
      481 aaacgggccc ccgtaccgcc gaaacagcgt ggccgggcgc gctcggcgtg ggtacggagc
      541 cgggctccgg ccccgtaccc acgccgccgc gccactcagg cccccgcgcc gctcaggccc
      601 cggccgtccc gcgtccggcg tccggactcg tactcaggcc cccacgtcgc gtcgtcgcag
      661 gtcttcctgc gtctcgcggc ggatcagcag ccgggccgta ccgccgtgga ccgcgacgac
      721 cggcggccgg cccacgaggt tgtaggcgga ggccatggac acctggtagg cgcccgccac
      781 cggcaccgcg aggagatcgc ccgggcgtac gtccccgggc agcgggacgt cggcggcgag
      841 gacgtcgccc gcctcgcagt ggcggcccac caccgtggcc gcgaccggtc cggcggtggg
      901 gacgcggccg accaggcggg gtgcgtagcg ggccccgtac agggcgggcc gggggttgtc
      961 gctcatgccc ccgtcgacgg cgacgaacag cgtccggccg gtgtgcttga cggcgaggac
     1021 gcggtacagc gccaccccgg ccggggccgc gatcgccctc cccggctcga tgaccaggcg
     1081 cggcacgggc agccccgcga ccgcgcagct ctcggccagt tcggcggtga ggcggcgcgc
     1141 gagggcggtc gggtcgagcg cgggctcgcc cggccggtgg gcgacgccgt ggccgccgcc
     1201 cagatcgagt tcggggaggg tgacgccgtg gctctcgtgt acgcgcgcca tcagcccgac
     1261 catgcggcgc acggccacca ggtacggctt cacgtcggtg atctgggagc cgatgtggca
     1321 gtgcagcccg gtcagttcga gggagctctg accgagcacc cgggcgatgg cgtgctgcgc
     1381 cgagccgtcc gtgagggaca ggccgaactt ctggtcctcg gttccggtac ggatcttctc
     1441 gtggccaccc gccgccaccc cgggcaccac ccgcaccatc accttctggc ggcgggcggg
     1501 cccggtgagc gcggcgatcc gggcgatctc cgaggggctg tcgacgacga tccgcccgac
     1561 gcccagccgg agcgcggtcg cgaggtcgcg gggcgacttc gcgttgccgt gcagcaccat
     1621 gcgctcgggc gggaacccgg cggcgtgcgc gaggtcgagt tcaccggccg aacagacgtc
     1681 caggccgagc ccctcctcgt cgatccaccg caccatcgcc cggcacagga acgccttggc
     1741 cgcgtacagg acgtcggctg cggggaaggc cgcgcggtag gtccggcacc gggtccgtat
     1801 ctcgtcctcg tccaccacgt aggcgggggt gtcgaagcgg tcggcggtct cggcgaggga
     1861 gaccccgccg acgctcaggt gcccgtgcgg gagccgggcc gtggaggccg gccagacgga
     1921 gaggtcgtcc ggcgcggtgg ggaggcgggt gggcagaagc tcggtcatga cggcgactcc
     1981 tcgggggcgg ggaacggggc gcgggtcacc ggacgacgcg ggtgggcagc aggtcgtcgc
     2041 ccgccagtgc gcgggtgacg gccggggccg agagcgccgg gtcgacgacg acccggtcga
     2101 cgccgagcgg ctccacgagc aggcgcaggg cgggctcggc gagccggatc gcggcgtggc
     2161 cggccccgag ggtcgcggtc agcaggccgc gcgcggtgaa gccgacggcg gtgcgctccc
     2221 ccagcggcgt acggaacatc cgcagtacgg gcccggcgtc ggtcgcacgg acgggcacga
     2281 agaggagccc ggggcggggg cgcgcgtcaa gggccggggc gtcggcccgc gaccggctgg
     2341 cacggtccgg ggctgtgccg tgtacacggt ccggggccac gctgcgggcg tgctcctggg
     2401 cggcgctccg gacccgggcc gcgctccggg cctggactgt gctcggggac tggaccgtgc
     2461 tcggggcctg gaccgtgccc cgggtgcggt cggcgggttc gccggggtcc ggttcgtcgg
     2521 ggtccggttc gtcgtcgtac gagatgaggc acacgggctt cctccggggg caggggcggc
     2581 cgtcgtccgg ccgcacgacg ccgaagctat gcccggcccg gccccctgcg ccctgccgcc
     2641 tgacgcgttg ttgacggccg ccgcccggtt catacgcatc gctgacgggc acggcgccga
     2701 cacgcggccg tgaagccccg ccgcacggcc gacactccgc gccctccccc acccgcgcgg
     2761 cccgccctca ccgactcggg ccggccgcac tcgcccgcgc ccatacgccg cctcagcccg
     2821 gcgccggggc cggccccgcc cgtacgccac ctcggcccgg gtgctcagcc ccacccgccc
     2881 ccaccgccgc agacgcagtt cgcagacgca gcccgcaacc gtcccccggc cggccccgtc
     2941 cccgggggct cagccccgga cgcgtgcccg gcgggacatc accgcgcgca ggacgcggcg
     3001 gccctccgtg gacaggtcca gcgccttgcg gaggcccgcg ccgctgcccg tcgtgccgga
     3061 ggtctcggcg aggatctcca ggatgcggac ctggcgttcc agctcccccg cgaccagcgg
     3121 gcccagggcg gccggttcgc cggtgcgggc ggcctcgacc aggtcgtccc cgtcctccgc
     3181 ccggcccccg tccggagcgt cgaaccgccc gtggacgcgg agcgcgacca gcgaacagag
     3241 atcggcccac tcccgcagcg cgggggcggc gaagtcggag ggcgcggtgg ccagggaggc
     3301 ccgtacgagc gcggccgggt catcggcgcc cgggaccgcc ccggcgtcgg cgtccagctc
     3361 cctgcgcacc gacgcgagcc ggttggccca atcccgaccc tcctcgcagc tcgcccagag
     3421 cgggcgcagg ggctcggtcc cggcgcccgc gagcagcggc aggcaccggt ccaggcaagc
     3481 cacggcagcg gcggccaggg tgcgctcatc ggctcgctcg atcagttcca acagactcat
     3541 cgacgtctcc ctcggtctac cgactacagc gccgaatggc tgaaaatcgt cacgttaggg
     3601 gagcgtccga cacggccggc acagaattca cggcgcgggc ggcccgttcg acctgcatcc
     3661 gggtgagcgc gcggacaaag aggatggcga ggacggcggc gacgatgtcc agcgcgtcgc
     3721 tggccaccac caggcccgcg gcccgcgcga cctcctcggg ctcgaaggcc cgcgaccaga
     3781 tcttttcggc gacgcgggtg gcgagcaggc tcaggaccca cgcgccccac cagagcttga
     3841 gcggggtctt gggcaccgtg cgccacccgt cgcccggccc ggtctgcgcg ctggcctccc
     3901 acaccccgct cgcgacgcgg taggggatcc agaggttggc gatcgggacg aaccagccac
     3961 cgatcgccca gccggggccc agccgctgca ctccggcgtg gaagacctcg gcgttccggc
     4021 gggtgcggtg gaaccagacg acgaagacga tggccgtcac caccagcgcc gtgccctgca
     4081 cgagggccgc gagcacgaaa taccgctcgg cgatctgggc cgcgcgcatg tggacgtccg
     4141 gggagccgcc ctccgccagg gcgccccagc ggctccgcac ccgcagcccg gtgacgacgg
     4201 cgaacacgtc ggcggcgatg accaccccga gcagcaccgt cacggctcgc gcgagggcga
     4261 cgggcgagcg cggccaggcg ccggcggtcc agccgcccgg cccgggcacc ggggccatca
     4321 gcccgccggg cagcggcggg cgggttcccg agcagaaggt gcacaggtcg tcggccgtga
     4381 cggccgttct ggtacggcaa cgggtacaga gcatgaagcg gtccccccag gacgcggtgc
     4441 ggtacggatg cacgggtgca cggccgcgcg ccctccccgg gaacacgcgg ccgacgacat
     4501 ggcgcgcccg gcgttcgccg ggctgtcagc cccgcatcct cgcaggtgag cggggtgagg
     4561 aacagggcgt tacacgtcgg gcggcatcga cggggagcgc cggcgaccgc atccaccctc
     4621 ctccgccccc tcgccgcacc ggccatccgt ccctccagcg gaatcagcac gaagcaggca
     4681 taccgaaccg actctttcca gtcaggtcta aaccattgac gggccgtaca acaccgcacc
     4741 accgaccgaa ggatcttcac agcccgggca caccaaccgt gcgatatgcg gtccagcccg
     4801 ccgcatcccg cactctccgc aaccgggcca cctcggcgac acgctcacgt cacctctgcg
     4861 acctgcaccg atgtgtccgc aagagagcca accgcgcgtg acctccttca gcgggcgtca
     4921 ctccccgtgt agacatggcc gaggcggccc cggcccaccc gagaggctgc ctcagccatg
     4981 ttctggaggg aaattcagcc atgtccagac ccacccgccg tcaggtcatc ggagtcgcca
     5041 ccggcgcggc cgcgagcatc gcgctcgtcg gtacggccgc cacgtccccg ggcgccgcgt
     5101 ccgccgcacc cgggaagacg gaggcccccg ccctggggcc cgcgcccttc gacgaggtgt
     5161 tccagggccg ccgcatccag ggcgcgcccg ccgcggccga cgcccatgcc catggccagg
     5221 cgcacgccca ggggcacgcc gggcacgacg ccgtctaccg ggtgtggatc gacggccgcg
     5281 aactccatgt gatgcagcac ggaagcagcg gctggagcag cgcgatcaac cactacgaga
     5341 ggttcgcgac cccgctcgac accgcgcgca ccgcggtcgc ctccctcaag ggcgcccacg
     5401 tcgtcccttt cgaccacacc gcctgagccg ggagcagcga ccatgaccgt acgcaagaac
     5461 caggcggacc tcacggcctc cgagaagagg gccttcgtcg ccgccgtcct cgggatgaag
     5521 cgcaagggcg tgtacgacga gttcgtctcc acccaccgca cccggttcgc gaccgacatg
     5581 aacaccggcg tgtacgtcgg ccatttcggc ccgtcgttcc tgccctggca ccgcaagttc
     5641 ctcatcgact tcgagcgcga gctccagaag ttcgacccct cggtgtcgat cccctactgg
     5701 gactggaccg cggacgacac cgtcgcctcc tccctctggg cgccggactt cctcggcggc
     5761 accggccgcc ccctggacga ccaggtgatg gacggcccct tcgcctactc cgccggcgac
     5821 tggcggatca acgtccaggt cgacagccgc gcgttcctcg cccgcaacct cggccaccgc
     5881 gtctccacgc tcccgacgag ggccgaggtg gactccgccc tcgccatccc cacctacgac
     5941 tccgccccgt tccgcgacgg ttcggccggg ttccgctccg cgctggaggg gtcggccggg
     6001 tacatgagca tgcacaaccg cgtgcacacc tgggtctggg gccagatgga gtccagcgtc
     6061 tccccgaacg acccggtgtt ctggctgcac cacgcgttcg tcgacaagct gtgggccgac
     6121 tggcaggcgc tccacccgac cgccgccaag tacctcccgg ccggcggcac ggccgatgtg
     6181 atcgacctga acgagaccat gcccccgttc ccggccacga ccccgcagga catgctggac
     6241 cacaccccct tctacaccta cgcctgaccg ccctgcggaa acgttccgcc gccgcccccg
     6301 ccgtcgtgac acggcggggg cggcggcgga cgtcgcgtac ggcgtgggac gacggcccgg
     6361 tccggccccg ccgcgggggt tcaccccgcg ctgccggtcc gcttcgccag ctcctggaac
     6421 tccgcccagc tcagcgcggg cttccgcggg tcccacagct tctgcgaggt ggccaccagc
     6481 ggcatctcga tcccctgcgc cacctgctcg gtggtctgcg cgttcgccag gtcgccccag
     6541 acggcgaacc ggccgccgag gatctgcttc gagtagcgct cggccacggg ctcggtgccg
     6601 cgcatgacca gcggggtcca ctgctcgtag atccgcttgc ccgtcgggta ggtgaagtcg
     6661 ttcggctcgc cgagcacgta gtagaggaac tcgtcgttga ggttcagcat cttgtagccc
     6721 gcggccaggt actcctgcgg cgggcggacg ccgtactcct tgccggtcca gtactcgatc
     6781 tcgatgttct cgtcggcctt gaccttcgtg ccccggaaga ggccgtcgtt ccacgccttg
     6841 gcggtccggc ccttggggac gacgacgtcg gcgcggtcgt tcagccagct cgtggccagg
     6901 tcctcgatgg tggccccggc gccgtgcttc ttctcggccg cccgctggag ctgcgggtag
     6961 gaggcggccg ggttctggac gaccagcgcc tggtactcgt ccgcgcccag gtgccagtag
     7021 cggcccggga acagctcggt gtactcgtcg agcagctcgt cgatgagctt ggccgcgccc
     7081 ggcttggaga tgtcgacgga cccctgcgac gcgacaccgg ccgtgttgcg cagctggagg
     7141 tcggggtggg cggcgagcac cgcgccgagg tgtccgggcg agtcgatctc ggggacgacc
     7201 tcgatgtgcc ggctgttggc gaggccgacg atgcggcgga cctcgtcctg ggtgagggcc
     7261 tcgtcggaga ccacttcggg gtgcgacttc gactcgatgc ggaacgcctg gtcgtcggag
     7321 aagtgcagac cgagctggtt cagcttgagg tcgcccatct cgcgtatgcg gtcctcgatc
     7381 cactccgcgc tgtagtgctt gcgcgcgatg tcgaggttga gcccgcgctg cggccggtcc
     7441 ggccggtcgt tgacgacgcc ctcgggcacg gcgccgtccg ccttcaggga ctgcttgagc
     7501 gtccgggtgc cgtagaagac gccggactcg tcgggcccgg tgatccgcac cttccggtcg
     7561 cgcacggtga gcgtgtacga ctcggcgggc cccgcgtcct tgccgccgag ggccagctcg
     7621 acgtcgcccg ccttcgccgg ttcggcgccc cggtagcgga tcttcagctc gtcggcgagc
     7681 agccgcgcct cgtcggccag gacctggctg cccttggcga tgacgacccc gctgcccttg
     7741 ccgggctgcc agccgggccc gcgggcggcg gtgtgctcgc gcacggcggg gatcgcgctc
     7801 ggcgtgctgg acatcggata gctgcgggtc ggcgaggggg cggcctcggc ggaggtgccg
     7861 gagggcgacg ccgtgtcgcc ggacgggccg ctgccggagc cttccggcca gacgacgacg
     7921 gtgaggacga cggcggccgc ggccgtgacg gccgcgccgg tgacgagggc accacgcgag
     7981 ggcgacatcg gaagggttcc tccattgtgg ggggatgtgc gggggaaaag agtgaagaga
     8041 tggagaaata ggtgagccgg atgcaagatt ggcacttttg tcccggactc gcccagtgag
     8101 gacatcgagg cggcgggcag gccccggccc cgcgctggtc aggcgtccat cacacgttcc
     8161 gaaactctcc cgttcgggtg attgttcagc ggctcgccgg gcgtcgcgcg cccggcctcg
     8221 ctagcgttgc ggcacattcg ttcctcgctc cactcgcaca cccattcccc tcctgcggat
     8281 ctcactcccc ggccgggcaa ccccgccgcc cccggacctg tcttcccagg acggagggtc
     8341 ccgtttccga gaccgcggag ccccctcccg ggaccacgga gtcccagccg ccgttgatca
     8401 cgaggagtcc acgctgtcca ggtccagcga gtcccccgcc ggcctgccga agcgacccac
     8461 gcccccggca ggccggtcgg ccgtgcccgt gcagccgcgc cctccggcgc cggacggggg
     8521 cccgggcgcg gagcacgccg ccgccccgcc ggatgatcat gccgtgggcc tggcccattt
     8581 caacagcctc cccttcgccg ccgccgaggc ggccttcctg gagtgctgcg gaagcctgcg
     8641 gtgggcgcac cgcatggccg cccaccgccc ctaccccgat ctcggcgccc tactggccgc
     8701 gtccgacgag gcgggctacg acctcgcgcc cggcgacatc gcggaggccc tggccgccga
     8761 gccggccacc tgcctgcacc acgacgcgcc ccgcgccgcc catctggcgc tgcgggccgc
     8821 gcacgcggcg tacgagagcc ggttcggcca cgccttcgtg atctgcctgg actcctacgc
     8881 gccctcccag cacgtggacc aggtgctggc cggcatccgg gtccggctgg cgcacgaggt
     8941 ggacgaggag cgggccgtga ccgccgagga gctgcgccga ctcgcccgga gccggatcgt
     9001 ggagctggtc acggcggacc ccggccggta gaccggcccg gcgcggcccg ccccggcggg
     9061 gccccggatc cggcacgacc ggcgtgcccg gctctagccc gtacgtgcct gtttgattgc
     9121 cggtttgatc acaccggagg ccccggcgcg aacgaaccga caatgcgtcg ctacgatggc
     9181 cggggccggt ggaccgtacc cggccgggtc agaccgacag tcaagccggc cgaccccaat
     9241 ccccgctccc ggagggttct tccgtgccgg ctggaacgct gtaccgcggc cgggaaggca
     9301 tgtggtcctg ggtggctcat cgagtcaccg gtgtcctcat tttcttcttc ctgttcgtac
     9361 atgtcctgga caccgcactc gtccgcgtat cccccgaggc gtacgacgac gtcgtggcca
     9421 cctacaagac gtggcccgtc gcgttcctcg aatacggcct cgtggccgcg attctcttcc
     9481 acgcgctgaa cggtctgcgg atcatcgccg tggacttctg ggccaagggc ccgcgcctcc
     9541 agaagcagat gctctggacc gtggtgggca tctggatcgt gctgatggtc ggggcgctct
     9601 accccgtcct cggtcacgcc gtacgcgatc tcttcgggag ctgaggccca tgtccagcga
     9661 gacctcttcc gcagccgcga tcggcgacgt cgagggcgtg agcctgtacg acgtcgacca
     9721 cccggccccg gtgatcgagc ccccgcgcaa gcgcacgggc aagaccccga aggccacgcg
     9781 cggcaacttc gagatgtacg cctggctctt catgcgcctg tcgggcatcg tcctggtcgt
     9841 cctcgtcatc ggccacctgc tgatccagct ggtgctcgac ggcggcgtct ccaagatcgg
     9901 cttcgccttc gtggcgggcc gctgggcctc gccgttctgg caggtctggg acctgctgat
     9961 gctgtggctc gccatgctcc acggcgccaa cggcctccgt acggtcatca acgactacgc
    10021 cgaacgggac aacacccgct tctggctgaa gatgctcctg tacaccgcca cggtgttcac
    10081 cgtcctgctg ggcacgctgg tgatcttcac cttcgacccg aacattcgct aggcgccggg
    10141 acagagggac cagaggaaac catgcagatc cacaagtacg acaccgtcat cgtcggcgcc
    10201 ggcggcgccg gcatgcgcgc ggccatcgag gccaccaagc gcagccgtac cgccgtgctg
    10261 acgaagctct accccacccg ctcccacacg ggcgccgcgc agggcggcat ggccgccgcg
    10321 ctcgccaacg tggaggagga caactgggag tggcacacct tcgacacgat caagggcggt
    10381 gactacctgg tcgaccagga cgccgccgag atcctcgcga aggagg
//
