LOCUS       NZ_CP070260            20978 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces californicus strain FDAARGOS_1210 chromosome.
ACCESSION   NZ_CP070260
VERSION     NZ_CP070260.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces californicus
  ORGANISM  Streptomyces californicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7919564)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T., Yan,Y.
            and Sichtig,H.
  TITLE     FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
            Supporting development and validation of Infectious Disease Dx tests
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7919564)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T., Yan,Y.
            and Sichtig,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2021) Institute for Genome Sciences, University of
            Maryland School of Medicine, BioPark II, 801 W. Baltimore St., Suite
            619, Baltimore, MD 21201, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT v. 8.0.0, HGAP v. 4
            Genome Coverage                   :: 624.55x
            Sequencing Technology             :: Pacbio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016906265.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 09:02:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,240
            CDSs (total)                      :: 7,147
            Genes (coding)                    :: 7,032
            CDSs (with protein)               :: 7,032
            Genes (RNA)                       :: 93
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 115
            CDSs (without protein)            :: 115
            Pseudo Genes (ambiguous residues) :: 0 of 115
            Pseudo Genes (frameshifted)       :: 36 of 115
            Pseudo Genes (incomplete)         :: 97 of 115
            Pseudo Genes (internal stop)      :: 12 of 115
            Pseudo Genes (multiple problems)  :: 27 of 115
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:25:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2174680
            Orig. end                         :: 2195658
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070260.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20978
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="14"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20978
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20978
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10978](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10978
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            1451..1876
                     /locus_tag="I6J40_RS09315"
                     /old_locus_tag="I6J40_09310"
     CDS             1451..1876
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018959947.1"
                     /locus_tag="I6J40_RS09315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09310"
                     /product="phage tail protein"
                     /protein_id="WP_030118741.1"
                     /transl_table=11
                     /translation="MTDNIFATSVFFKLAIGGSDLGAFHTCSGLGAEVEMETYAEGGNN
                     GFTWHLPGRITWTNITLTRPVTADTMKIARWLNETIRRVEPKDGEIVALRPDLSRIISW
                     QVHGIVPVRWQGPSFDPADSQAAIETLEIAHEGLEPS"
     gene            1997..2716
                     /locus_tag="I6J40_RS09320"
                     /old_locus_tag="I6J40_09315"
     CDS             1997..2716
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018959946.1"
                     /locus_tag="I6J40_RS09320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09315"
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="WP_030118740.1"
                     /transl_table=11
                     /translation="MSPALRASRARAQLTIMEPPSTVGAKPGGTLARLTLQFNPAKLSL
                     SKTTEWRRTPSRMAGQSALPEFVGSGPRALSLEVFLDATATHDNSVEKAVEQLMTACVP
                     TPSSLARKTPASPWVRFDWGTSKTTSFDGVLSNLSVSYTLFDVDGKPLRATCSLSIEEA
                     SVDPAGQNPTSGSKEARRTHRVVAGDSLPLLAWREYGDATAWRTIAHANDIDDPMQLTP
                     GRELLVPGRDARPGEDV"
     misc_feature    complement(2029..2045)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.99"
                     /tool="antismash"
     gene            2716..4497
                     /locus_tag="I6J40_RS09325"
                     /old_locus_tag="I6J40_09320"
     CDS             2716..4497
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018959945.1"
                     /locus_tag="I6J40_RS09325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09320"
                     /product="VgrG-related protein"
                     /protein_id="WP_030199587.1"
                     /transl_table=11
                     /translation="MSGTKSPGRSFAADPIVEAPAELPAAWATQLVSCVVDENVGLPDT
                     AVLMYRDPDHTFLAKTGIGMGTPLKISVVTVQDRARERLFTGEVTAIELDTDTTGSFTV
                     VRAFSKAHRLQRGRKVEAYRNMKTADIVRKVAAGAGLACGKVEAASITYKQLTQPNVSD
                     WEFLQHLAAESGATVRVDDKGVLQFTKPDPASSAPSPSTSATRNPMVLEYGNNLLALRA
                     VLTGADGSDSVEVRGWNVDTKTRLVARKQSVRSDTVAPGMSPSTAAKIFGSGSRTTIAD
                     TPYRTQAETRAVAGSLAASVSAGFGEVEAVAYGNPKLRAGVPVALGNVGPAFSGRYTAT
                     AAHHVLDPDTGYRTTVLVSASPDRSLSGLTGGGNAPSRGPRMPGLAIGVVTDIREEGRG
                     QRGWVRLKFPWLDDTYVTDWVRTVQWGGQGGGGVFSPEVNDEVLVGFEQGLLDSPYVLG
                     GLYNGVDKPSPHDVPLVDPTSGKVNRRSLVSRSGNRLELLDAPRGPAGVRIATGDKRLD
                     VVLDEKKGEITLTVKARGGVRELSSVTLSSSGITLDAGAAGDVTIKGRSVKVNGKTGVT
                     VDGGLLAVLKAKLIKIN"
     gene            4647..4964
                     /locus_tag="I6J40_RS09330"
                     /old_locus_tag="I6J40_09325"
     CDS             4647..4964
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611501.1"
                     /locus_tag="I6J40_RS09330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09325"
                     /product="PAAR domain-containing protein"
                     /protein_id="WP_030118738.1"
                     /transl_table=11
                     /translation="MPPAARTGDSTAHGGLIGTPPPGAPAVATVLIGGRPAAVTGSLHA
                     CVVPPHALLGPGNVIMPNPAAAIGGAVLIGGLPAARMGDKTSCGAPIVSGAFNVLIGGP
                     M"
     gene            4961..5434
                     /locus_tag="I6J40_RS09335"
                     /old_locus_tag="I6J40_09330"
     CDS             4961..5434
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611500.1"
                     /locus_tag="I6J40_RS09335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09330"
                     /product="GPW/gp25 family protein"
                     /protein_id="WP_030199590.1"
                     /transl_table=11
                     /translation="MSGGGFIGRGWGFPLRTGPTGGIALVERDKEIEEAIGLILGTAPG
                     ERPMRPDFGCGIHEYVFAPGDGATAGRIAQEVRAALERWEPRIEVTDVVVAFDAVEEGT
                     LYIDVHYTVRATNDLRNLVFPFYTIPSSEAGPESERPVPDGSASRARREAGAR"
     gene            5434..7395
                     /locus_tag="I6J40_RS09340"
                     /old_locus_tag="I6J40_09335"
     CDS             5434..7395
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457205.1"
                     /locus_tag="I6J40_RS09340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09335"
                     /product="putative baseplate assembly protein"
                     /protein_id="WP_030118736.1"
                     /transl_table=11
                     /translation="MALPSPNLDDRRFQQLVDEAKRFVQQRSPEWTDHNVSDPGVTLIE
                     TFAYMVDQLLYRLNRVPDKNYAAFLDLLGVTLFPPTVARAEVDFWLSAPQPETVHLPAG
                     TEVATVRGETEEPVVFSTVEDLPIVPSSLVRLVTAPVSGDQTDRTGPLGAGKDVPCFQS
                     RPEPGDALLFGLPTAVPRCIVAVRLDSRVEGVGVDPRQPPLVWEAWDGARWATCATGVD
                     STGGLNRPGEVVVFVPAGHTASVVAGTRAGWLRCRVTAPEPGQPFYSESPTIREAEVFT
                     VGGTTAAEHAETVLDVPLGVSEGVAGQRFSVSRAPLLLDGDPPVVQVSTDEGWQVWTPV
                     EHFGASGPGDRHVRIDAVAGEFAFPPEVREPDGTMRAYGAVPEKGAQLRIPRYRTGGGA
                     AGNVARGAISVLRSSVPYVAGVDNREAATGGVDGETVENAKVRAPNILRVQERAVTAED
                     HELIAREAAPSLRRVRCLPAVPGEAGAVRVLVVPDAVPDDDGHLRFEQLIPSDAVLAAV
                     TERLDERRLVGTRLIVEPPAYQGVTVVARLVAAPADVDRVRAQALEALFRHIDPLRGGA
                     DGRGWPFGRAVQYGEVFAVLQSVEGAGLVEDVRLFPADPITGRRGAAADRVDVAPGALV
                     FSHQHQVVVTASGAGEVV"
     gene            7392..7976
                     /locus_tag="I6J40_RS09345"
                     /old_locus_tag="I6J40_09340"
     CDS             7392..7976
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060048.1"
                     /locus_tag="I6J40_RS09345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09340"
                     /product="phage tail protein"
                     /protein_id="WP_030199594.1"
                     /transl_table=11
                     /translation="MTRAAVPGLPSRYPIGDLLPALYADDDLAQRFTAGLDTVLAPVLS
                     TLDNLPAYVDPALAPADFLPWLASWVGVEADPAWPVELRRAVVARAVELHRWRGTRRGL
                     VERLRLCCGVHAEVRDGGGAAWSAEPGAALPPPPAGELLVRVWPVRAGAPVDAHRVQEV
                     AAGCCPVHLGCRVEVLPGPPEGFDTPEQTGG"
     misc_feature    8076..8091
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.96"
                     /tool="antismash"
     misc_feature    8688..8702
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.8"
                     /tool="antismash"
     gene            8707..9471
                     /locus_tag="I6J40_RS36045"
     CDS             8707..9471
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072198.1"
                     /locus_tag="I6J40_RS36045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_030196961.1"
                     /transl_table=11
                     /translation="MRPARPVARRPVVRPVAEDETPDGPPCPACGTPNLAGRRFCRRCA
                     APLQVREQAAALPWWRTVWPFRRRVRGGSGRMLRRTLLVLAVAGLVLAGFLFFPLGRYA
                     YEDVRDKLGKTSEISPTGAAASGEAPGHPAGAAIDGVTNEYWGAPALGASLTCSFGTPF
                     RLVGVVVHTGVSTEPQEFRRGARPTRADLLVTTEDGKVHRKSLSFNDKPGKQESRMGIS
                     DVVSVELVLREAAGQGKGRPIAVGEIEFFRRA"
     misc_feature    complement(9596..9607)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 16.74"
                     /tool="antismash"
     misc_feature    complement(9597..9614)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     misc_feature    complement(9683..9694)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.23"
                     /tool="antismash"
     gene            10001..10978
                     /locus_tag="I6J40_RS09355"
                     /old_locus_tag="I6J40_09350"
     CDS             10001..10978
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018492272.1"
                     /locus_tag="I6J40_RS09355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09350"
                     /product="terpene synthase family protein"
                     /protein_id="WP_032746465.1"
                     /sec_met_domain="T1TS (E-value: 8.8e-69, bitscore: 231.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFESAGCHPGLAATREAAWEWAESEGLDLSVPARRKMIRTRPEL
                     WISLIFPNATQEHLDLFCQWLFWAFLVDDEFDDGPAGRDPRVCEAAIARLVDVLDGAAP
                     NGPMERALAGLRERTCAGRSPQWNRQFRRDTAAWLWTYYAEAVERVSGQVPSRAEFVKH
                     RRDSVAMQPFLCLHEITAGIDLTDSARSLPAYIALRNAVTDHSGLCNDICSFEKEAALG
                     YEHNAVRLIQRDRGCTLQEAVDEAGIQLARVAERVLRAERELIEEIEAAGIEGPTREAL
                     ERCVQDYRGLVRGDFDYHARAERYTRPDLVERDQRDSLSRHFAA"
     gene            11293..13587
                     /locus_tag="I6J40_RS09360"
                     /old_locus_tag="I6J40_09355"
     CDS             11293..13587
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378967.1"
                     /locus_tag="I6J40_RS09360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09355"
                     /product="peptidoglycan recognition protein"
                     /protein_id="WP_030196950.1"
                     /transl_table=11
                     /translation="MRVQRRVWTTAAVTTAAVAGVLVFQGVTGASDADRDGLAADAKSA
                     PAKSDVHRTALKTSADGDSASLARRDTEPFSLLGVTWTDPAAKVDGRVEARTRSAATGE
                     WTGWLPLDTEIDGRTEAGRSGVRGTTEPRWVGPSNGVEVRVTSADGARSGLPDGLRLDT
                     VDPGGAPAPLAAEPVAFAADGTPGEDGAPGEDPSPTLPAEEPDATPTDEPAPTPTTESP
                     APPSPTPTPSASTASPTPSTSPTTPSASPTPTPGPPSTVPQPPIVSRAAWKADESLNSE
                     APDYLDQVKAVFVHHTAQTNAYSCADSAAIVRGLHTYHVKSNGWKDLGYNFIVDKCGTV
                     FEGRKGGVDRPVMGAHTYGFNRDTAGIAVIGMYTDTKAATAATTAVARVAAWKLGQYKA
                     DPAGTVQLTAGANGNNMDHKKFVAGNQYAFQRISGHRDGFATECPGLSLYQQLPAIRTL
                     AAGPVSGLTISSVTGANASGSTYYTQSKVTVGWKATTPAAFVKSYELLVGGKPVATVKG
                     DASSASATLAVGKHTVQVRATHQSGKTSLSPAATVVADRTAPAFSTKPSLTLRTGTVNA
                     TAVPLTLKWKATDSAALKEVRLTAPVARTYGPTTGSASHTAKPAAATTWKMTAYDRAGN
                     TAAASVSGTPVILQESAAKKSGTWTTKSSSSYLGGKSYSSSTKNASLTWTFTGRSAAWV
                     VSRAATSGQAHVYVDGKKTATVDLKSSATKYRDAIWATSWSSSAKHTVKIVVVGTKGRP
                     ALTTDGLVYLK"
     gene            13627..15096
                     /locus_tag="I6J40_RS09365"
                     /old_locus_tag="I6J40_09360"
     CDS             13627..15096
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966159.1"
                     /locus_tag="I6J40_RS09365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09360"
                     /product="carboxylesterase family protein"
                     /protein_id="WP_030196948.1"
                     /transl_table=11
                     /translation="MSDVETGSAPEVRTAYGTVRGAVERGVAVFRGIPYAAAPVGALRF
                     RAPAPPEPWTGVREAVAYGPTAPKRPYAPPLDRLLPDPAVPGDGWLNLNVWTPSPGAAA
                     LPVLVWIHGGSLVHGSSAVPVYDGTAFARDGVVLVSVNYRLGVEGFGVFPDAPANRGLL
                     DQLAALEWVRDNIAAFGGDPDRVTVAGESAGAISIAALLASPRSAGLLRRAVLQSGAPA
                     ALPPAAGRRTTELIARRLRAPATAEALAAVDPEALLTAQTEVTSGGNPLTGRTSFQIVV
                     DGELLPHDPVAALHAGASAGIDLLMGTNSEEYRLWFVPGGLTERISQLQLRLALLKFRV
                     PNATARTYRANRPGATPGEILGALATDLLLRVPLNRLADVRTTAPGSTYVYEFGWPTPV
                     QRLGACHALELGFVFDTLDHPDTRALTGPDAPGELASAMHRAWVDFAAHGDPGWPSWDA
                     RRPVTVFGPTAPSLVLAPRDDELRCWKPRRR"
     gene            complement(15203..16153)
                     /locus_tag="I6J40_RS09370"
                     /old_locus_tag="I6J40_09365"
     CDS             complement(15203..16153)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611464.1"
                     /locus_tag="I6J40_RS09370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09365"
                     /product="CopD family protein"
                     /protein_id="WP_239589808.1"
                     /transl_table=11
                     /translation="MPGPPAARSRTGPLLVCAAGGLALLIALLGPGVAARGTGELQMPG
                     AGLTAALRTVLFTALALHLGELLAPQLIRPVRGRPRTPVRSWAVLASLAGAAAAAGQIV
                     RLAVVGGLGLTETYGTREGGLLLVVANGLVLAAICAATKRPDLALVPLAVVIGAEALRA
                     HPEAYSPAVGAALTVVHLTAASLWCGGLLYVLRTMWHWRGSPVAARTLLGRYARLAAWL
                     YAALATTGTVSTLRRLPLDVVFTSAYGRTLLAKLVLMAVVSALALAARRRMLQDHDPSV
                     AHRLARHEQVVLGLVVVVSAILTAVPDPHRISPGG"
     gene            complement(16570..16785)
                     /locus_tag="I6J40_RS09375"
                     /old_locus_tag="I6J40_09370"
     CDS             complement(16570..16785)
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550129.1"
                     /locus_tag="I6J40_RS09375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09370"
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_030118725.1"
                     /transl_table=11
                     /translation="MADIESARTVFEKFDANGDGLITAGEYKSAMAQLGDPFVTETVAQ
                     AIINSHDANGDGLLTFDEFWAAQNKG"
     gene            complement(16826..17722)
                     /locus_tag="I6J40_RS09380"
                     /old_locus_tag="I6J40_09375"
     CDS             complement(16826..17722)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072193.1"
                     /locus_tag="I6J40_RS09380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09375"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_030196944.1"
                     /transl_table=11
                     /translation="MHGYGNPPGRRRALGAGAGALAAALLAGCAELSGRREPTAGLPGR
                     AAPTSGASGRAAPTTGASAPPAPGASGPARAPAPAPAPRRFPGLPVRIAHGPRDRPRVA
                     LTFDGRGDPDLAVAALARCERAGARVTVLAVGTWLARHPELARRILDGGHELGNHTEHH
                     LDLAALDESAAYEEIAACARRLRRLTGSAGAWFRPSPTTYASPLVERLARRAGYPHVLA
                     CDVESLDHAATRVATVTRKVAGELRNGSVVELSLGRPVTVAALPLLLAEIGRRGLHAVT
                     ATELMARPATGAARTAG"
     misc_feature    complement(17831..17844)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.72"
                     /tool="antismash"
     misc_feature    complement(17917..17932)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.08"
                     /tool="antismash"
     misc_feature    17925..17941
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.19"
                     /tool="antismash"
     misc_feature    17929..17943
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.08"
                     /tool="antismash"
     gene            complement(18138..18653)
                     /locus_tag="I6J40_RS09385"
                     /old_locus_tag="I6J40_09380"
     CDS             complement(18138..18653)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060059.1"
                     /locus_tag="I6J40_RS09385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09380"
                     /product="ATP-binding protein"
                     /protein_id="WP_030196941.1"
                     /transl_table=11
                     /translation="MMVGMAGLEGVDEPRPRSSATAARWTSTMDDEQAFKALELFGDPT
                     EGEVRLPSRPESAATARRLTSCVVLRQWSLSPQTAEFAVLLVSELVGNAVRHTGARVFG
                     LRMVRRRGWIRIEVRDPSRGLPCLMPVREMDVSGRGLFLVDKLSDRWGVDLLPRGKVTW
                     FEMRIADR"
     gene            complement(18928..19695)
                     /locus_tag="I6J40_RS09390"
                     /old_locus_tag="I6J40_09385"
     CDS             complement(18928..19695)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (5-246). E-value: 9e-75. Score:
                     243.1. Matches aSDomain:
                     nrpspksdomains_I6J40_RS09390_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966166.1"
                     /locus_tag="I6J40_RS09390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_09385"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_030196940.1"
                     /transl_table=11
                     /translation="MTVTFEVRDGVGTIRLDRPPMNALDVAIQDRLRELAEEATRREDV
                     RSVILYGGEKVFAAGADIKEMQAMDHTAMVLRSKGLQDAFTAVARIPKPVVAAVTGYAL
                     GGGCELALCADFRIAADNAKLGQPEILLGLIPGAGGTQRLARLIGPSRAKDLIFTGRMV
                     KAEEALALGLVDRVVPAAEVYEQAYAWAAKLAKGPALALRAAKESIDAGLETDIDTGLT
                     IERNWFSGLFATEDRERGMRSFVEEGPGKATFG"
     aSDomain        complement(18958..19680)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I6J40_RS09390_ECH.1"
                     /evalue="9.00E-75"
                     /label="I6J40_RS09390_ECH.1"
                     /locus_tag="I6J40_RS09390"
                     /protein_end="246"
                     /protein_start="5"
                     /score="243.1"
                     /tool="antismash"
                     /translation="EVRDGVGTIRLDRPPMNALDVAIQDRLRELAEEATRREDVRSVIL
                     YGGEKVFAAGADIKEMQAMDHTAMVLRSKGLQDAFTAVARIPKPVVAAVTGYALGGGCE
                     LALCADFRIAADNAKLGQPEILLGLIPGAGGTQRLARLIGPSRAKDLIFTGRMVKAEEA
                     LALGLVDRVVPAAEVYEQAYAWAAKLAKGPALALRAAKESIDAGLETDIDTGLTIERNW
                     FSGLFATEDRERGMRSFVE"
ORIGIN
        1 cgcccgccgc gatgcccgta cggtcggccg ccgtaccggc ctccgtgccg agcaccgctc
       61 ccgacgcctc cgctgtcccc tcatccgcac ccggcgcgcc ctccgttcag cgtgcggcgg
      121 cccccggagg ctcggccggt acgcgtacga ggtcggccgc cgccactccc ccgcccccgg
      181 tgcgcatccg gccggtcgag cggccccgcg cggccgccca aggccccggc gtcctggccc
      241 cggcgcctct ggtccagcgg gcgcggaccc tgctcccgga ccgtgggctg accgtcaaca
      301 ccggctccgc cgaggggttt tcggctgccc cgatcccgac cgcgggcggc tccgccccgc
      361 gtccggtcgt ggcggcgacc tggcggcgcg acctgccgca gccggacgcc ggcaccggcc
      421 cggcgccacg cgatcccgcc tccgcctccg gtcccggtcg tcccagccgg agccagggcc
      481 gggaccgggg cacaccggct tccggttccg ggcggaccgg ggcgggcccc tccacgcgtt
      541 ccggcccagc gcccggccct gtggtccagc gctcgacggc cgctccggcg cctgcgctca
      601 cccgcacgcg gcgccagtcc cccaccgcat ccccggcacc cgggcggctt cccggcgcgc
      661 ctcggcagca ggccaccgct tccccggccc ccgcgcgggc gcacgccccc gcttcacccc
      721 ccgccgtcca gcgcaccgcc accgcgccgc cggccccggc aggccccgcc gcgccgctcc
      781 cccacgtcca ggccgtccgc cccgacccgc cgtcggccgc ccccggggtc ccggccgccg
      841 cgcccaccgc tcagggtgcg cgcgccgtgc ccgtcgtccg gccgcatccg cccgccgcgc
      901 cccgggccgc cgacgccgcc gtccccgtac agcggcttgc cctccccgtg gtgcccgact
      961 ccgcaggccc cccggtgccc gccccggacg acgctccggg cgggcccccg ccgggtctct
     1021 ccgtgcgcgt accaccgcgc acgcccgcgc ggagccccgg cgcggggcgc ccggagacca
     1081 gagcgcaggc cgtccagcgc gcggcggcgg acgccgggat caccggcgta cccgtccggg
     1141 ccgcgccgtc caagcccgtg gtccagcgga cgggcccgga ggccggggcc gaggacacgc
     1201 ccgacgccgc cccggccaac cggatgagcg gggcggaggt cgaggagttg gcccgccgcc
     1261 tcatcgaccc ggtgagccgg ctcctccgcg ccgatctgcg ccggggccgg gagcgcagcg
     1321 gccgactgca cgacggccgc cgctgacggt ccgccaccca ccgcccggcc accgacgacg
     1381 accacaggct ccggggccgc ccctcggccc gcaggcaaga cacgagcagc aggacagacg
     1441 agagagacgc atgaccgaca acatcttcgc gacgagcgtg ttcttcaagc tcgcgatcgg
     1501 cggcagcgac ctgggcgcgt tccacacctg ctcggggctg ggcgccgagg tggagatgga
     1561 gacctacgcc gagggcggca acaacgggtt cacctggcat ctgcccggcc ggatcacctg
     1621 gacgaacatc acgctgaccc gcccggtgac cgccgacacg atgaagatcg cgcggtggct
     1681 gaacgagacg atccggcggg tcgagcccaa ggacggcgag atcgtggcac tccgtcccga
     1741 tctcagccgg atcatcagct ggcaggtcca cggcatcgtt ccggtccgct ggcagggccc
     1801 gtccttcgac ccggccgact cccaggcggc gatcgagacg ttggagatcg cgcacgaggg
     1861 cctggagccc tcctgacaga ccgccgcgcc cgtccggcag cacccggaga cagacccggc
     1921 agtgcccgga aaacagaccc ggagcagacc ggagcagacc cggaagcagt cccggaacca
     1981 ggaaaggagg aacgccgtgt cacccgctct ccgcgcgagc cgcgcccgtg cccagctgac
     2041 catcatggag ccgccgtcga cggtcggcgc caagccgggc ggaacgctcg cccggctcac
     2101 gttgcagttc aaccccgcga agctgtcgct gagcaagacc accgagtggc ggcgcacccc
     2161 gtcccggatg gccgggcagt ccgcgctgcc cgagttcgtc ggcagcgggc cccgcgccct
     2221 gtcgctggag gtgttcctcg acgccaccgc cacccacgac aactccgtgg agaaggcggt
     2281 cgagcagttg atgaccgcgt gtgtccccac gcccagcagt ctcgcccgca agacccccgc
     2341 cagcccctgg gtgcggttcg actgggggac gtcgaagacg acgtcgttcg acggggtgct
     2401 ctccaacctc tcggtctcgt acacgctgtt cgacgtcgac gggaagccgc tgcgcgccac
     2461 ctgctccctg tcgatcgagg aggcgagcgt cgatccggct gggcagaacc ccacctcggg
     2521 gtcgaaggag gcgcggcgca cgcaccgggt ggtggccggg gacagcctgc cgctgctggc
     2581 ctggcgggag tacggggacg ccaccgcgtg gcggaccatc gcgcacgcca acgacattga
     2641 cgatccgatg cagttgacgc ccggacgtga gctgctggtg cccggacggg acgcccgccc
     2701 cggagaggac gtgtgatgag cgggacgaaa tcgcccggcc ggtccttcgc ggccgacccg
     2761 atcgtggagg cgcccgccga gctgcccgcc gcctgggcca cccagttggt gagctgcgtg
     2821 gtcgacgaga acgtggggct gcccgacacg gccgtcctga tgtaccggga cccggaccac
     2881 acgttcctcg ccaagaccgg tatcggcatg gggactccgt tgaagatctc ggtcgtgacc
     2941 gtccaggacc gggcgcggga gcggctgttc accggggagg tcaccgcgat cgaactggac
     3001 accgacacca ccgggtcgtt caccgtggtg cgggcgttct ccaaggcgca ccggctccag
     3061 cgcggccgga aggtggaggc gtaccggaac atgaagacgg cggacatcgt ccgcaaggtc
     3121 gccgccgggg ccgggctcgc ctgcggaaag gtggaggccg cgtcgatcac gtacaagcag
     3181 ctgacccagc ccaacgtctc cgactgggag ttcctccagc acctggccgc cgagagcggg
     3241 gccaccgtgc gggtggacga caagggcgtg ctgcagttca ccaagccgga tcccgcgtcc
     3301 tcggccccct cgccgtcgac gtccgccacg cgcaacccga tggtcctgga gtacgggaac
     3361 aacctgctgg ccctgcgcgc ggtgctgacc ggggccgacg ggtcggacag tgtggaggtg
     3421 cgcggctgga acgtcgacac caagacgcgg ctggtggcgc ggaagcagtc cgtgcgcagc
     3481 gacaccgtcg ccccggggat gagcccgtcg acggcggcca agatcttcgg gtccggctcg
     3541 cggacgacga tcgccgacac gccgtaccgc acccaggcgg agacccgggc ggtggccggt
     3601 tcgctggccg cgtcggtgag tgccgggttc ggcgaggtgg aggcggtggc gtacgggaat
     3661 ccgaaactgc gggcgggggt gccggtggcg ctcggcaacg tgggcccggc gttctccggc
     3721 cgctacaccg cgaccgccgc gcaccacgtc ctcgacccgg acaccggata ccggaccacc
     3781 gtgctcgtca gcgcctcgcc ggaccgttcg ctgtcggggc tgacgggcgg cgggaacgcc
     3841 ccctcgcgcg gaccgcgcat gccgggtctg gcgatcggcg tggtcaccga catccgcgag
     3901 gagggccggg gccaacgcgg ctgggtgcgg ctgaagttcc cctggctgga cgacacgtac
     3961 gtcaccgact gggtccgcac cgtgcagtgg ggcggccagg gcgggggcgg ggtgttcagc
     4021 ccggaggtca acgacgaggt gctggtcggg ttcgaacagg ggctgctgga cagcccgtac
     4081 gtgctcggcg ggctgtacaa cggcgtcgac aagccgtccc cgcacgacgt cccgctcgtc
     4141 gatccgacca gtgggaaggt caaccgccgt tcgctggtgt cgcgttcggg caaccgactg
     4201 gagctgctcg acgccccgcg cggtccggca ggggtgcgca tcgcgaccgg tgacaagcgg
     4261 ctcgacgtcg tgctggacga gaagaagggg gagatcacgc tgacggtcaa ggcacggggc
     4321 ggtgtacggg agttgagttc ggtgaccctg tcctcgtcgg gcatcaccct ggacgccggc
     4381 gcggcgggcg acgtgaccat caagggccgt tcggtgaagg tcaacgggaa gacgggggtc
     4441 acggtggacg gcggtctgct cgcggtcctc aaggccaagc tcatcaagat caactgacca
     4501 ccgcacccgc ccgcgcccac cctgtccgct cgcgcccacc ccgtccaccg cacccactcc
     4561 gtccacccgg cctctcacgg ccccgcttcc gcaccacggc cccgcgcccg taccacgtcc
     4621 gcaccacagc aaggagaacc ccggccatgc cccccgcagc ccgtacgggc gacagcaccg
     4681 cacacggcgg cctcatcggc accccgcccc cgggtgcgcc ggccgtggcc accgtgctca
     4741 tcggcggccg gcccgcggcc gtcaccggaa gcctgcacgc gtgcgtcgtc cccccgcacg
     4801 cgctgctcgg acccggcaac gtgatcatgc ccaaccccgc ggccgcgatc ggcggcgccg
     4861 tgctgatcgg cgggctgccc gcggcccgca tgggcgacaa gacctcctgc ggggcgccca
     4921 tcgtcagcgg agcgttcaac gtcctgatcg ggggcccgat gtgagcggcg gcgggttcat
     4981 cgggcgcggc tggggcttcc cgctgcggac cgggccgacg ggcgggatcg ccctggtgga
     5041 gcgggacaag gagatcgagg aggccatcgg gctgatcctc gggacggcgc ccggcgagcg
     5101 gccgatgcgc cccgacttcg gctgcgggat ccacgagtac gtcttcgcgc ccggcgacgg
     5161 ggcgacggcc gggcggatcg cgcaggaggt ccgcgccgcg ctggagcggt gggagccgcg
     5221 catcgaggtg acggacgtgg tggtcgcgtt cgacgcggtc gaggagggca cgctctacat
     5281 cgacgtgcac tacaccgtgc gggccaccaa cgacctgcgc aacctggtct tccccttcta
     5341 cacgatcccg tcgtcggagg cggggccgga gtcggagcgg ccggtgccgg acgggtcggc
     5401 gtcgcgggcc cggcgtgaag cgggggcgcg ctgatggccc tgccctcccc caacctggac
     5461 gaccgccgct tccagcaact cgtggacgag gccaagcggt tcgtgcagca gcgctccccc
     5521 gagtggaccg accacaacgt gtccgacccc ggggtgacgc tgatcgagac gttcgcgtac
     5581 atggtcgacc agttgctgta ccggctgaac cgggtccccg acaagaacta cgcggccttc
     5641 ctcgacctgc tgggcgtgac gctgttcccg ccgaccgtgg cgcgggccga ggtcgacttc
     5701 tggctctccg cgccgcagcc ggagaccgtg cacctgccgg ccggcacgga ggtggcgacg
     5761 gtgcgcgggg agaccgagga gccggtggtg ttctccacgg tggaggacct gccgatcgtg
     5821 ccgagttcgc tggtccggct ggtcaccgcg ccggtctcgg gcgaccagac ggaccggacc
     5881 gggccgctgg gcgcgggtaa ggacgtcccg tgcttccagt cgcgcccgga gcccggcgac
     5941 gccctgctgt tcgggctgcc gacggcggtt ccccggtgca tcgtcgccgt gcggctggac
     6001 agccgggtgg agggcgtggg cgtggacccg cgccagcctc cgctggtgtg ggaggcgtgg
     6061 gacggggccc gctgggcgac ctgtgcgacc ggcgtggaca gcaccggcgg gctcaaccgg
     6121 ccgggcgagg tcgtggtgtt cgtcccggcc gggcacaccg cgtcggtggt ggccgggacc
     6181 cgggcggggt ggctgcgctg ccgggtgacc gcgccggagc cgggacagcc gttctactcg
     6241 gagtcgccga cgatccggga ggccgaggtc ttcacggtcg gcggcacgac ggcggccgag
     6301 cacgcggaga ccgtcctcga cgtgccgctc ggggtgtcgg agggcgtcgc cgggcagcgg
     6361 ttctcggtga gccgggcgcc gctgctgctg gacggggacc cgccggtcgt tcaggtctcg
     6421 acggacgagg gctggcaggt gtggacgccg gtcgagcact tcggcgcctc cgggcccggt
     6481 gaccggcatg tgcggatcga cgccgtcgcc ggggagttcg cgttcccgcc ggaggtgcgg
     6541 gagccggacg gcacgatgcg cgcgtacggg gcggtgccgg agaagggcgc ccagctccgc
     6601 atcccccgct accgcacggg cggcggggcc gccgggaacg tcgcccgggg tgcgatctcc
     6661 gtgctgcgca gctcggtgcc gtacgtcgcg ggcgtggaca accgcgaggc ggcgaccggc
     6721 ggcgtcgacg gggagaccgt cgagaacgcg aaggtgcgcg cgcccaacat cctgcgggtg
     6781 caggaacgcg cggtcaccgc cgaggaccac gaactgatcg cccgggaggc ggccccgtcg
     6841 ctgcgccggg tgcggtgcct gcccgcggtg ccgggcgagg ccggtgcggt gcgggtgctg
     6901 gtggtgccgg acgcggtgcc cgacgacgac gggcacctgc ggttcgagca gttgatcccc
     6961 tccgacgcgg tgctcgcggc ggtcaccgaa cggctcgacg agcggcggct cgtcggcacc
     7021 cggctgatcg tggagccgcc cgcctaccag ggcgtcacgg tcgtcgcccg gctggtggcc
     7081 gcgccggccg acgtggaccg ggtgcgggcg caggcgctgg aggcgctgtt ccggcacatc
     7141 gacccgttgc ggggcggggc ggacggccgg gggtggccgt tcgggagggc cgtgcagtac
     7201 ggggaggtct tcgccgtgct ccagagcgtg gagggggcgg ggctcgtgga ggacgtccgg
     7261 ctgttcccgg cggacccgat cacggggcgg cgcggggcgg cggcggaccg ggtggacgtc
     7321 gcaccggggg ccctggtctt ctcgcaccag caccaggtgg tcgtcaccgc gagcggggcc
     7381 ggtgaggtcg tatgacgcgg gcggcggtgc ccgggctgcc cagccggtac ccgatcggcg
     7441 atctgctgcc cgccctgtac gcggacgacg atctggcgca gcggttcacg gcggggctgg
     7501 acacggtgct ggccccggtc ctgtccacgc tggacaacct gcccgcgtac gtcgatccgg
     7561 cgctggcccc ggccgacttc ctgccgtggc tggcgtcctg ggtgggggtg gaggccgatc
     7621 cggcgtggcc ggtggagctg cggcgcgcgg tggtcgcgcg cgccgtcgag ctgcaccggt
     7681 ggcgcggcac ccggcggggg ctcgtcgagc ggctgcggct gtgctgcggg gtgcacgcgg
     7741 aggtccggga cggcgggggc gccgcctggt cggccgaacc gggcgccgcc cttccgccgc
     7801 cgccggccgg ggaactgctc gtccgggtct ggccggtgcg ggcgggggct ccggtggacg
     7861 cgcaccgcgt ccaggaggtc gccgccggct gctgccccgt ccacctcggc tgccgggtgg
     7921 aggtcctgcc gggcccgccc gaagggttcg acacgccaga acagacagga ggctgacgcg
     7981 atgcgttcgt gcccggcgtg cggtacggcc aacggcgaga ccgacgactt ctgcggcaac
     8041 tgcgggagct acctgggctg gtcgtcccag cccgtacgcc gctcgcgcac accgctgccg
     8101 gacccggaac cggagcccgt cccggacccg gaaccggaac ccgatccggc cccggcaccg
     8161 cgaccggagc cagggcctgc gccgggccgc ccggcgcccg cgcccgaggc ggcgccgaaa
     8221 ccggccccgg cccccgcgcc cacacccgca ccgagccccg gtccggcacc ggagccggct
     8281 gccggccgcg cgcccgagcg cacaccgcga ccgcgcgtac cggaaccgga ggacgcaccg
     8341 gaaccggcca ccgcaccgca ggccgtgacg gacgcggccc ccgcgcctcc gacaacggcg
     8401 ccggcccccg tcgcacctcc cgcgccgtcc gcgcccccgg cgcacgcgcc ggggccaccc
     8461 gcacgcccgg agcaaccacc cgcacccccg gtacggcggc cctccccgcc cccggcgcaa
     8521 cccctcacgc cacccacatc acccacgcct cccccgcccc gcacgcctcc cgcacccccg
     8581 gagcgccccg cccccgcccc cgtacgcccc gggcttccgg cgtccgctcc caccgcgacg
     8641 ccgtccgcgg cctccggaag cgcgcccggt gaagcggcgg ccgggacgga cgagccggtc
     8701 cgggccgtgc ggccggccag gccggtggcg cggcggcccg tcgtgcggcc ggtggccgag
     8761 gacgagacgc cggacggtcc gccctgcccc gcctgcggta cgccgaacct cgccgggcgg
     8821 cggttctgcc gccgatgcgc cgctccgctc caggtccggg agcaggccgc ggccctgccg
     8881 tggtggcgca cggtgtggcc gttccgccgc cgggtgcgcg gcggttcggg ccggatgctg
     8941 cgccggacgc tgttggtgct ggccgtggcc gggctggtgc tcgcgggctt cctgttcttc
     9001 ccgctggggc ggtacgccta cgaggacgtc cgggacaagc tcggcaagac gtccgagatc
     9061 agccccaccg gagcggccgc gagcggcgag gctcccgggc atccggcggg ggcggcgatc
     9121 gacggcgtga ccaacgagta ctggggggcg cccgcgctcg gcgcgtcgct gacctgctcg
     9181 ttcggcactc cgttccggct ggtcggtgtg gtggtgcaca ccggtgtgtc gaccgaaccg
     9241 caggagttcc ggcggggtgc gcgcccgacc cgggcggatc tgctcgtcac caccgaggac
     9301 ggcaaggtcc acaggaagtc cctgtccttc aacgacaagc cgggcaagca ggagtcgcgg
     9361 atgggcatca gcgatgtcgt ctccgtggag ctggtgctgc gggaggcggc cggccagggg
     9421 aagggacggc cgatcgcggt cggggagatc gagttcttcc gacgagcctg aggacgctcg
     9481 accacccggg gctgaagcac ggtccgccgt cccgaggccc ggggtgcggt ccgccgtccc
     9541 gaggcaggag ctcgccggag cacggtccgt caacccaagg ccccagctcg ccgaagtaac
     9601 cgctttcagc gatcgggaac acgccgggac gacaccccgg cagacacaga cgacccagta
     9661 ccgatcagga aaatattgac gatcaaacat tttcggtcac acatgcttcc ctccgcaccc
     9721 ccactcgggg ttgactgggc atcacccatg gtgacgcgct cgcccaccgg ctcgcctgcc
     9781 gtgcccgccg tcccgggctt ccggcggagg aaggaggagg actgcgatgg ccctcccacc
     9841 tcgcacggtc gccccgtcgg ccggtgtccg ggctcgcggc cgccggctcc ggacgggccc
     9901 gtcccctgct cggtcacccg gaatgcgtcg tacatatcgt ccgcccgtat tcatcagatg
     9961 aggggcagca atgagccata tcacgttacc cgcgtttcac atgccgttcg agagcgccgg
    10021 ctgtcatccg ggtttggccg ccacgcgtga agccgcctgg gaatgggccg agtccgaggg
    10081 tctggacctt tccgtcccgg cccgccggaa aatgatccgg acccgcccgg aactgtggat
    10141 ctccctcatc ttcccgaacg ccacccagga acatctcgac ctgttctgtc aatggctgtt
    10201 ctgggccttc ctcgtggacg acgagttcga cgacggcccg gcgggacgcg atccccgggt
    10261 gtgcgaggcg gccatcgccc gcctggtgga cgtcctcgac ggggccgcgc cgaacgggcc
    10321 gatggaacgg gccctggccg gactgcggga gcggacctgt gcgggcaggt caccgcagtg
    10381 gaaccggcag ttccggcggg acaccgccgc ctggctgtgg acgtactacg ccgaggccgt
    10441 cgagcgggtc tccggacagg tgccgagccg ggccgagttc gtcaagcacc gccgtgattc
    10501 ggtcgccatg cagccgtttc tctgcctgca cgagatcacc gcgggaatcg atctcacgga
    10561 ttccgcccgg agtctgcccg cctatatcgc cctgcggaac gcggtcaccg atcattcggg
    10621 gctctgcaac gacatctgct ccttcgagaa ggaagcggcc ctcggttacg agcacaacgc
    10681 cgtccggctg attcagcgcg accgggggtg cacgctccag gaagccgtcg acgaggccgg
    10741 aattcaactg gcacgggtgg ccgaacgcgt actccgggcg gaaagggagc tgatcgagga
    10801 aatcgaggcg gcgggtatcg agggcccgac ccgggaggcc ctggagcgct gcgtccagga
    10861 ctaccggggg ctcgtccggg gcgacttcga ctaccatgcg cgtgccgagc gctacacgcg
    10921 tccggacctg gtggagcggg atcaacggga ctccctgtcc cgccacttcg ccgcctgagc
    10981 gaacgggccg gccgggtccg ccgggtgcgc gaagcactcc ggcggacccg gtcggcccca
    11041 ccgccgggcg cgtccgcggg ttccggcacc gcccgcacgc accgccaccg gcacgccccc
    11101 gcaccacccg caccacctgc cccggcccgg ggccgccgca ccgcgccccg ggccccatgg
    11161 aagactgagg gccgcagcat gtcccgggtc gcccccaccg gccgggccga cgagcgcgtc
    11221 gtgcccccgg tcagcgcctg gccggtcgga atgccctgcc cttcagtcag cgacgtcccc
    11281 gggatgacac atatgagagt gcagcgaaga gtctggacca cggccgccgt cacgacggcg
    11341 gccgtggcag gtgtcctggt gttccagggc gtgacgggcg cctcggacgc cgaccgcgac
    11401 gggctggcgg cggacgccaa gtccgccccg gccaagtccg atgtgcaccg gaccgcgctc
    11461 aagacctccg ccgacggcga ctccgcctcg ctcgctcgcc gcgacaccga gcccttcagc
    11521 ctgctcggcg tcacctggac cgaccccgcc gcgaaggtgg acggccgcgt cgaggcccgt
    11581 acccgctccg ccgccaccgg cgagtggacc ggctggctgc cgctggacac cgagatcgac
    11641 gggcgcaccg aggccggccg gtccggcgtc cgcggcacca ccgaaccccg ctgggtcggc
    11701 ccctccaacg gcgtcgaggt ccgtgtcacc agcgccgacg gggcccggtc cgggctgccc
    11761 gacggactgc gcctcgacac cgtggacccg ggcggcgccc ccgccccgct cgccgccgaa
    11821 cccgtcgcgt tcgccgccga cgggacgccc ggcgaggacg gcgcacccgg cgaggacccg
    11881 tcgcccacgc tgcccgccga ggagccggac gcgaccccca cggacgagcc ggcgcccacg
    11941 ccgaccaccg agtcccccgc gccgccgagc cccaccccca cgccctccgc gagcaccgcg
    12001 tcccccacgc cgtccacgtc gccgacgacg cccagcgcct ccccgacgcc gacgcccgga
    12061 ccgccgtcca ccgttccgca gccgccgatc gtctcccggg cggcctggaa ggcggacgag
    12121 tcgctgaaca gcgaggcgcc cgactacctc gaccaggtca aggccgtctt cgtccaccac
    12181 acggcgcaga cgaacgccta ctcctgcgcc gattcggcgg ccatcgtgcg cggcctgcac
    12241 acgtaccacg tgaagtcgaa cggctggaag gacctcggct acaacttcat cgtcgacaag
    12301 tgcggcacgg tcttcgaggg ccgcaagggc ggcgtggacc ggcccgtgat gggcgcgcac
    12361 acctacggct tcaaccggga caccgccggg atcgccgtga tcggcatgta caccgacacc
    12421 aaggccgcga ccgccgcgac caccgccgtc gcccgcgtcg ccgcgtggaa gctcggccag
    12481 tacaaggccg acccggccgg cacggtccag ctcaccgccg gggccaacgg caacaacatg
    12541 gaccacaaga agttcgtcgc cgggaaccag tacgccttcc agcggatctc cggacaccgc
    12601 gacgggttcg ccaccgagtg ccccggcctc tcgctctacc agcagctccc cgccatccgc
    12661 acgctggccg ccgggcccgt ctccgggctc accatctcct cggtgaccgg ggcgaacgcg
    12721 tcgggatcca cgtactacac ccagtcgaag gtcaccgtcg gctggaaggc gaccacgccc
    12781 gccgccttcg tgaagagcta cgaactcctc gtcggcggga agcccgtggc gaccgtcaag
    12841 ggcgacgcgt cctcggcctc cgccacgctc gccgtgggca agcacaccgt gcaggtccgg
    12901 gccacgcacc agtcggggaa gacctcgctc tccccggcgg cgaccgtggt cgccgaccgg
    12961 accgcgccgg ccttctccac caagccgtcc ctcaccctgc gcaccggcac ggtgaacgcc
    13021 accgccgtcc cgctcaccct gaagtggaag gccaccgaca gcgccgcgct caaggaggtc
    13081 cgcctcaccg cgcccgtcgc caggacgtac ggcccgacca cgggcagcgc ctcgcacacc
    13141 gcgaagcccg ccgcggccac cacgtggaaa atgacggcgt acgaccgggc cgggaacacg
    13201 gccgccgcct cggtctccgg caccccggtg atcctccagg agtccgccgc caagaagagc
    13261 ggcacgtgga ccaccaagtc ctccagcagc tacctgggcg gcaagtcgta ctccagcagc
    13321 accaagaacg ccagcctgac ctggacgttc accggccggt cggccgcgtg ggtggtgtcg
    13381 cgggccgcca catcggggca ggcgcacgtc tacgtcgacg gcaagaagac cgccaccgtg
    13441 gacctgaagt cctccgccac caagtaccgg gacgcgatct gggcgacctc ctggtcctcc
    13501 agcgccaagc acacggtcaa gatcgtcgtc gtcggcacga agggccgccc ggccctgacc
    13561 acggacgggc tggtctacct gaagtagccg cgcgccaccg caccgcgaga ggggttggca
    13621 cacaccatgt ccgacgtcga gacggggagc gccccggagg tgaggaccgc gtacggcacg
    13681 gtgcgcggtg cggtggagcg gggtgtcgcg gtcttccgcg gcatcccgta cgcggcggcc
    13741 ccggtgggcg cgctgaggtt ccgggcgccc gctccgccgg agccgtggac cggggtgcgg
    13801 gaggccgtgg cgtacgggcc gaccgccccg aagcggccct acgccccgcc gctggaccgg
    13861 ctgctgccgg atccggcggt gccgggggac ggctggctca acctcaacgt gtggacgccc
    13921 tcccccgggg ccgccgccct gcccgtcctc gtgtggatcc acggcggatc gctggtgcac
    13981 ggctcttccg cggtgccggt gtacgacggg accgcgttcg cccgggacgg ggtggtcctc
    14041 gtctccgtca actaccggct gggtgtcgag ggtttcggcg tcttcccgga cgcgcccgcc
    14101 aaccgggggc tgctcgacca gctcgccgcg ctggagtggg tgcgcgacaa catcgcggcg
    14161 ttcggcggcg atccggaccg ggtgacggtg gccggggagt ccgcgggcgc gatctcgatc
    14221 gccgcgctgc tggcctcgcc ccgttcggcg gggctcctgc ggcgggcggt gctccagagc
    14281 ggggccccgg ccgcgctccc cccggccgcc gggcggcgga cgaccgagct gatcgctcgc
    14341 cggctcagag cgcccgccac ggcggaagcg ctggccgccg tggacccgga ggcgctgctg
    14401 accgcccaga cggaggtgac cagcggcgga aacccgctga ccggccgcac ctccttccag
    14461 atcgtggtgg acggggaact gctgccgcac gatccggtgg cggcgctgca cgcgggcgcg
    14521 tccgccggca tcgacctgtt gatggggacg aacagcgagg agtaccggct ctggttcgtg
    14581 cccggcgggc tgaccgagcg gatcagccag ctccaactgc gcctggccct gctgaagttc
    14641 cgggtgccga acgccaccgc gcgcacctac cgggccaacc gtccgggcgc cacgcccggg
    14701 gagatcctcg gtgcgctcgc gaccgacctg ctgctgcgcg tcccgctgaa ccggctggcc
    14761 gacgtccgga ccaccgcgcc gggttcgacg tacgtctacg agttcggctg gcccaccccc
    14821 gtgcagcggc tcggggcctg tcacgcgctg gagctgggct tcgtcttcga caccctcgac
    14881 caccccgaca cccgggccct gaccggcccg gacgctcccg gggagctggc gtccgcgatg
    14941 caccgggcgt gggtggactt cgcggcgcac ggggacccgg ggtggccgtc ctgggacgcg
    15001 cggcgcccgg tgacggtctt cgggcccacg gcgccgtcgc tggtcctggc cccgcgcgac
    15061 gacgaactgc gctgctggaa gccgcggcgg cgctgaacgg cgccgccctg acggggagcg
    15121 cgcggacgag gagaccgggg tcggactggt ccagttgctc cccgtcgcat cctgaacgta
    15181 cagccgtgct tcaggcgggc cctcagcctc ccggcgagat ccggtgcggg tcggggacgg
    15241 cggtgaggat cgccgagacc accacgacca gtcccagcac cacctgttca tgacgggcca
    15301 gccggtgcgc gacagatggg tcgtggtcct ggagcatgcg ccgcctggcc gccagtgcca
    15361 gcgcgctgac cacggccatg agcaccagct tggccagcag ggtgcgtccg taggcggagg
    15421 tgaacaccac gtccagcggc agccggcgca gtgtcgaaac ggtgccggtg gtggcgaggg
    15481 ccgcgtacag ccaggccgcc aggcgggcgt agcggccgag cagcgtgcgg gccgcgacgg
    15541 gcgagccgcg ccagtgccac atcgtgcgca ggacgtacag cagcccgccg caccagagcg
    15601 aggccgcggt cagatggacg acggtgaggg cggcgccgac cgcggggctg tacgcctccg
    15661 ggtgggcgcg cagggcctcc gcgccgatga ccaccgcgag cgggacgagc gcgaggtccg
    15721 ggcgtttggt cgcggcgcag atcgcggcga ggaccaggcc gttggcgacg acgaggagca
    15781 gtccgccctc gcgggtgccg tacgtctcgg tgaggccgag tccgccgacg acggcgaggc
    15841 ggacgatctg cccggccgcc gctgcggccc cggcgagcga ggcgagcacg gcccagctcc
    15901 ggacgggggt gcgggggcgg ccccggacgg gccggatcag ctgcggggcg aggagttcgc
    15961 ccaggtggag ggcgagggcg gtgaacagga cggtacggag cgccgcggtg agccccgcac
    16021 cgggcatctg aagctctccg gtgccgcgcg ccgcgacgcc ggggccgagc agggcgatga
    16081 ggagcgcgag gccgcccgcc gcgcagacca gcagcgggcc ggtccgggag cgtgcggccg
    16141 gcggcccggg tatcgcaccc gtgcggggcg cgtggccgac gggtctcggc gcggcggtcg
    16201 tcaagaacag gccgagccgg ttctgagcgg ccgggtcggc gggaggtccg gagaacgtca
    16261 cggcccgatc ctcacccgcg accgaaaagg cggcaagccg cgcataacgg acggttaagg
    16321 caggctcggc ggacggttaa ggcgtgttgg gagatgggtg aggcgcgtcc ggcagacggt
    16381 ttacggcggg cccggcggac ggtttacggc gggcccggtg aacggcccaa gcgcacccgg
    16441 cggactgctg acggcgggtc cggtgaaggc gggccggcgg gtcaggtcgt gccgggcgcc
    16501 gcaggccggg cgggctccgg ccggccgcgc ggggcgtgcc ccggcgggcc ggccggtccc
    16561 cgtccggggt cagcccttgt tctgcgcggc ccagaactcg tcgaaggtga gcaggccgtc
    16621 accgttggcg tcgtgggagt tgatgatcgc ctgcgccacc gtctcggtga cgaaggggtc
    16681 gcccagctgg gccatcgcgc tcttgtactc gccggccgtg atgagcccgt cgccgttcgc
    16741 gtcgaacttc tcgaataccg tccgcgccga ctcgatgtcc gccacagttc caccccttcg
    16801 tgatgccgaa tgttcagggg tcagattatc cggccgtccg ggcggccccg gtggccggtc
    16861 gggccatcag ctccgtggcc gtcaccgcgt gcagcccgcg ccggccgatc tcggcgagga
    16921 gcagcggcag cgcggccacg gtgacggggc gtccgaggct cagctccacc accgacccgt
    16981 tgcgcagttc cccggcgacc ttgcgggtga cggtggcgac gcgggtggcc gcgtgatcga
    17041 gcgactccac gtcgcaggcg aggacgtggg ggtagccggc ccgccgtgcg agccgctcca
    17101 ccagcgggga ggcgtacgtg gtgggcgagg gccggaacca ggcgccggcg gacccggtga
    17161 gccggcgcag ccgccgggcg caggcggcga tctcctcgta cgccgcgctc tcgtcgaggg
    17221 ccgccaggtc gaggtggtgc tcggtgtggt tgcccagctc gtggcccccg tcgaggatcc
    17281 gccgggccag ctcggggtgc cgggcgagcc aggtgccgac ggcgagcacg gtgacgcgcg
    17341 caccggcccg ttcgcaccgg gcgagggcgg cgacggcgag gtccgggtcg ccgcgcccgt
    17401 cgaaggtgag ggccacccgg ggccggtcgc gcggcccgtg cgcgatccgc acgggcagcc
    17461 cggggaaccg gcgcggagcg ggggcgggag cgggtgcgcg agcggggccg gaagcaccgg
    17521 gcgccggcgg ggcggaggcc ccggtcgtgg gcgccgcccg acctgaggcc ccggacgtgg
    17581 gcgccgcccg gccggggagg cctgcggtcg gctcccgtcg gccggagagc tccgcgcacc
    17641 cggcgaggag ggcggcggcc agcgctccgg ccccggcgcc gagcgcgcgg cggcggcccg
    17701 gcgggtttcc gtaaccgtgc atccccgacc acctcacgct ccaccgccgc caccggtacc
    17761 cccggattcc ggggacagag tagaggcggt acgggcgaaa tgcggcgatt gagtagttca
    17821 tcaaatgatc tatgaatcat tcaagggatg ccataatgat gcatggaatg ccaggttagt
    17881 gatggagcac acctgcgatt cacgcgccaa gcgcccgatt acacctggaa tatcccgaca
    17941 agtcgctttg gcaccgaggt cgcccgtctg ccatagtcgg agccacgacc tccattgacc
    18001 cgggcaaggt cgccagaagc ggccgtgaac acacccccca tttcacggcc cccgtcagaa
    18061 gcccccgcag cgccccacca cggcgaaccg ggggcttctg cgtatccggc cggaaaaccc
    18121 gagggggcga gccccggtca gcggtcggcg atgcgcatct cgaaccaggt gaccttgccg
    18181 cgcggcaaca ggtccacgcc ccaccggtcg gacagcttgt cgaccaggaa gaggccccgg
    18241 ccgctgacgt ccatctcgcg caccggcatg aggcacggca gaccccgcga ggggtcgcgc
    18301 acctcgatgc ggatccagcc ccggcggcgc accatccgca gaccgaagac ccgggccccg
    18361 gtgtgccgta cggcgttgcc gaccagctcc gagacgagga gcaccgcgaa ctcggcggtc
    18421 tgcggcgaga gggaccactg gcggagcacg acgcaggagg tgagcctgcg ggccgtcgcc
    18481 gccgactccg gacgcgacgg cagccggacc tccccctcgg tcggatcgcc gaacaactcc
    18541 agcgccttga acgcctgttc gtcatccatg gtcgacgtcc accgtgccgc ggtcgcgctg
    18601 ctgcgcggtc gcggctcatc cacaccctcc aggcccgcca tgcccaccat catggccgca
    18661 gacatcgccc cccggggtcg ttccggggga atccgcgccc ggccaacagg ccgcccgagg
    18721 aaggcttttg gcatatgccc cgggcatgac agcatcctga acgcccgcac tgagctgcgg
    18781 tgttgctccg gcgtccgcag cccgtccggg cggagagcgc tccgggcctt aaggttctct
    18841 taaggcccgg ataatccgcc ctgacggatg aacacctcgc gcgggaccgt ccgacccgac
    18901 taccggggca cccgttccga ctacgggtca gccgaacgtg gccttgcccg ggccctcctc
    18961 gacgaagctg cgcatgcccc gctcgcggtc ctccgtggcg aacagaccgg agaaccagtt
    19021 ccgctcgatc gtcagcccgg tgtcgatgtc cgtctccagt ccggcgtcga tcgactcctt
    19081 ggcggcgcgc agcgccagcg cggggccctt ggccagcttc gcggcccagg cgtacgcctg
    19141 ctcgtagacc tcggccgccg ggaccacccg gtcgaccagg ccgagcgcca gggcctcctc
    19201 cgccttgacc atgcggccgg tgaagatgag gtccttggcc cgggaggggc cgatcagccg
    19261 ggccagccgc tgggtgccgc ccgcgcccgg gatcagcccg aggaggatct ccggctggcc
    19321 gagcttggcg ttgtcggcgg cgatgcggaa gtcggcgcag agggccagtt cgcagccgcc
    19381 gccgagcgcg tagccggtga cggcggcgac gaccggcttc gggatgcggg cgacggcggt
    19441 gaaggcgtcc tggagcccct tggaccggag caccatcgcg gtgtggtcca tcgcctgcat
    19501 ctccttgatg tccgcgccgg ccgcgaacac cttctcgccg ccgtagagga tcacggagcg
    19561 cacgtcctcg cgccgggtcg cctcctcggc cagctcgcgc agccggtcct ggatggcgac
    19621 gtccagggcg ttcatgggcg gccggtcgag ccggatggtg ccgacgccgt cgcgtacttc
    19681 gaaggtcaca gtcatggcta gaggttaacc accgctaacg acggcgggcc cggtgccgtt
    19741 ggtcacagca ccgggcccgc ccgggtcgtt caggagcgga ggcggtctac ttcttccact
    19801 ccgcccagtc catgttccag ccgttgaggc cgttgtccgg ctggatcacc ttgtcgtggg
    19861 agttcttcac gatgaccacg tcgccgatca gcgacttgtt gtagaaccag gccgccggcg
    19921 tctggttgtc gtagccgccg cgcacatcgc gcagaccgac gcagccgtgg ctggtgttgg
    19981 tgttgccgaa gatcgaggac gcgccccagt agttgccgtg caggaaggtg cccgacgtgg
    20041 agagccgcat ggcgtgcggg acgtccttga tgtcgtactc gccgccgaag ccgacggtgt
    20101 caccgttcat acgggtcacc ttgagcttct cgctgatgac catctgaccg ttgtacgtgg
    20161 tcgtcgccgg ggcgcccgcc gagatcggga tgtccttgat ctgcttgccg tcgcggacca
    20221 ccttcatccg cttcgcgctc gcgtccacgg tggagacctg gctgcggccg atggtgaact
    20281 tcaccgtctt ggtctgcttg ccgtagacgc ccggccggcc ctcgacgccg tcgaggttga
    20341 gctcgacggt caccttggtg cccgacgccc agtacttctc cgggcggaag tcgaggcggt
    20401 cgttgccgaa ccagtggccc tcgatctcga cggccggttc ggccgtcacc ttgatggcgc
    20461 gctcgaccgc gtccgggtcg gtgatgcccc gggtgaagtt gatggagacc ggcatgccga
    20521 ccccgacggt ggagccgtcc tcgggcgtgt actgcccgat gaaggtgttc gcggggacga
    20581 gcgtggtgaa ggtggtgtcc ttcgccgact cacggccctc ggagtccttc gcgaccgcgt
    20641 gcaccgtgta cttggtggcc gcggcgaggt gccgctccgg cgtccagctc gcgccgtccg
    20701 ccgcgatctc gccctcgacc tcgttgccct tggggtccgc gaccttgacc gtggtcagct
    20761 tgccctgctc ggcgccgatc ttcagggcgc cgctggtcgc caccgcgtcc gccccgtcct
    20821 tcggcgcgat ggtcacgacg gcctgcgagg cggtcgtgtc gcccttcttc gtcccgcccg
    20881 cggggtcctt cttgtccccc gcgtcggcgc tgccgccgca cgccgtcacc agcatcagca
    20941 gtgcgcccag catcagggcg gaaagccccg ttcccccg
//
