LOCUS       NZ_CP070260            11356 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces californicus strain FDAARGOS_1210 chromosome.
ACCESSION   NZ_CP070260
VERSION     NZ_CP070260.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces californicus
  ORGANISM  Streptomyces californicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7919564)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T., Yan,Y.
            and Sichtig,H.
  TITLE     FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
            Supporting development and validation of Infectious Disease Dx tests
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7919564)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T., Yan,Y.
            and Sichtig,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2021) Institute for Genome Sciences, University of
            Maryland School of Medicine, BioPark II, 801 W. Baltimore St., Suite
            619, Baltimore, MD 21201, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT v. 8.0.0, HGAP v. 4
            Genome Coverage                   :: 624.55x
            Sequencing Technology             :: Pacbio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016906265.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 09:02:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,240
            CDSs (total)                      :: 7,147
            Genes (coding)                    :: 7,032
            CDSs (with protein)               :: 7,032
            Genes (RNA)                       :: 93
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 115
            CDSs (without protein)            :: 115
            Pseudo Genes (ambiguous residues) :: 0 of 115
            Pseudo Genes (frameshifted)       :: 36 of 115
            Pseudo Genes (incomplete)         :: 97 of 115
            Pseudo Genes (internal stop)      :: 12 of 115
            Pseudo Genes (multiple problems)  :: 27 of 115
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:25:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 344539
            Orig. end                         :: 355895
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070260.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11356
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11356
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11356
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6356](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6356)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(1445..3286)
                     /locus_tag="I6J40_RS01350"
                     /old_locus_tag="I6J40_01350"
     CDS             complement(1445..3286)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955801.1"
                     /locus_tag="I6J40_RS01350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_01350"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_078866716.1"
                     /transl_table=11
                     /translation="MMLHPELLRAANTARRPLGLATALLAAVTATHLAQAVLLALVLAR
                     IAQGATADLAPLLTAVIAVVLARALLGRAQRMIAVTAGAAVRVRLRDTLLVRLGALGPT
                     AVTGARAGAVRATLVDGVEGVDAYVSRYLPQALITCLVPPALLVAVALVAPYAALALGL
                     ALLLALLGPRGWDRLLARRGKDHWDSYEALAADYLEALQGMPTLRAAGAVGRVRERLEL
                     RSAALHRSTVAKLRVSLVDTGLTDLAVQGGTVAAVLVACSSAATGATAATGTYLLLLLA
                     SECFRPVRDLSREWHAGYLGVSAADGIAALRTAEPAVPDRGTGTALWDGPPEVRFENVR
                     FTHPGSDRPALDGVAFTAAPGRTTAVVGPSGAGKSTLLSLLLRQRDPDSGIVTVAGTDT
                     AAYTLASLRRGIAVVSQETYLFHATIAENLRIARPAATDGQLRAAARDAGIDDEISRLP
                     DGYATLVGERGATLSGGQRQRIALARALLAEAPVLVLDEATSAVDERGQARIVRALSAV
                     GRDRTRIVVAHRLDAVRHADHIVVLDAGRVAAEGDHATLLAGGGVYAALVAAGRTTREA
                     DDPGPAHEAAEPTTRKADDPDPAHEATGRTPQEERAA"
     gene            complement(3283..4986)
                     /locus_tag="I6J40_RS01355"
                     /old_locus_tag="I6J40_01355"
     CDS             complement(3283..4986)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452724.1"
                     /locus_tag="I6J40_RS01355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_01355"
                     /product="hypothetical protein"
                     /protein_id="WP_030188433.1"
                     /transl_table=11
                     /translation="MPDAPDRAAVPTRDPRAEPPGGSAAKDPAGSSAGAPDCLGRALAD
                     ARSPRVPALSPYVPERPFPWSGPGLPLTDRGRRRTDAAAAFGGPRRRAAAGARTDSGPG
                     SAVTGSAAVGAAPIRHDAPLDLARLLRLSLAAPAGTSGRLRPVPSAGALHPVRAHLLVG
                     PGCSLPPGRYAYDPHTHRAHPRGPAPDGVPAGALAVLTVAASRTVAHYGHRAWPLLLLD
                     AGHAAAALAQAGPPTADVLVCLDADGALLSAAAGLPRAPARHSEWQAAELEPPLAAVWF
                     TPTGGSVRTIDPLSAWATRARASAPVRAPGPPIAQAHELSYTQRLLSLLAQAPARPAGT
                     WHPASRPEGVTGKTLTTRRSAPPDDLRRPPERELLASVLTTARTASPAGPDWTVVTGGA
                     APALYTGRPGRPGLLLHAHGDARPTLAHWAARQTWIGTTGAVLLAHGLPDDAPPAEVRT
                     GHLAAGYAIGLAQTHATALGLRSRPIGSWQQADLGAALGEAPGRDWIVHGLALGAPPAK
                     ATTPPATRTATAPAAPTAAPRATRPTPHSTDPPAPGTTARTTPPGEEERP"
     gene            complement(5001..6356)
                     /locus_tag="I6J40_RS01360"
                     /old_locus_tag="I6J40_01360"
     CDS             complement(5001..6356)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016828012.1"
                     /locus_tag="I6J40_RS01360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_01360"
                     /product="YcaO-like family protein"
                     /protein_id="WP_030188431.1"
                     /sec_met_domain="YcaO (E-value: 1.6e-44, bitscore: 151.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVEALVDPVSGIVRDVAPVEHPTGAPPRYTAMTADVADARRLGA
                     WPADRVSLGTTFGDREGAWIAAVAEAVERYCGNRVPPPGHPRAPRRATAAELAAEGHRL
                     YGPGSLPTYASWQYGRTGFPYAELTPDTPALWTRATENGRPCWAPVALTHLNWRQGDLR
                     SLPRTHHLNYAGIATGQGLDDAVERGLLEIVERDALELWWHLDGPTRGIDPATVPGLTD
                     DLAGCALDVHIVEMPSEFAPCVAALVHDPERGIYAAGFACRYDPAEAARKAVLEAVHTW
                     VFTQGAVDADGWVYRAIDAGMLARGLYLDHRADRRYLDDCGTDFAAVRDLGAHVQVWLD
                     DRMAPLARRFTAPALGVVPVAAVEPGSRAALDAALAAGGHRVITADLTTEDVAETSLRV
                     ARVLVSGLVPNAPAAFGYFGCPRFADAALDRGWRSQPPTGPEDFTLAPPPHM"
     gene            complement(6437..8035)
                     /locus_tag="I6J40_RS01365"
                     /old_locus_tag="I6J40_01365"
     CDS             complement(6437..8035)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377868.1"
                     /locus_tag="I6J40_RS01365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_01365"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_030188429.1"
                     /transl_table=11
                     /translation="MKTRTVYVPTPDGTALATDICLPDGPRPCPAVLIRTPYGRGAHRA
                     ESRGWAAHGYAVLAQDVRGRHGSPGEWQPYGEHEGPDGTAAIAWVRSQPWSNGEVVAAG
                     ASYAAYCALVPALTGPDDRRRTGARPGEAHRDGGPDAVIAAVPALGLVETAREPSGPER
                     LWARAGWWAAHGDRRDSEPDALSRALASDPRLLEHLPVTRVAERLAEGLGRELPSWPCL
                     WTGRDRGRLADAGSSSRLPLLAVGGTRDPFADDTVALWRGWGGPARLLLGPWGHHLTAD
                     PAAPPRAHVNLGALYVRWARAALAGRLDPRPRGVIALGGSGRWHRVTGTASAPGASEPC
                     RPEAAVRWPFGSRTGLRLLHGAEFTAHPDRPVRSDDLTVPADRERPDRCLLVSPPLPRP
                     LDLAGLAVARLHVTADTPSADWAVRLTTLDPAGRAEPLAFGIVRRTDPPGRAADITVPL
                     GTLGRRLPAGTRLRAEVAGHHFPAHARNPHTGEDPVTATRLAPSHRTVHARGSALHLPV
                     VARRRYVEPVPEICR"
     gene            complement(8032..8973)
                     /locus_tag="I6J40_RS01370"
                     /old_locus_tag="I6J40_01370"
     CDS             complement(8032..8973)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452727.1"
                     /locus_tag="I6J40_RS01370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_01370"
                     /product="hypothetical protein"
                     /protein_id="WP_030188426.1"
                     /transl_table=11
                     /translation="MTRSRLAPGAGIVTVPGAGPVLRSPEGEFLRIDTGGVDGDVLARR
                     LTGQAEAASGDPHDDRLHRLIEAFEADGYAVASSPRPPLSGRVVHLLGDPALTEPLTRC
                     VRGEGAEVRPITPDGVAELALAGPDDEHAEGRVAVVWCLDSPAAEGVWNAADRLPDHRV
                     AWLRCHREGSHVWTEPLAAAPGDVSSRHVRLRRLAATPAHRELAAYWAGHRTPDTGPHP
                     TAASAALIAALLTADLIAWAGAKAHADAEAREGSGPVRRAGLPPRRRLRRIDLRDLTVT
                     EHPALPVPDVAPLPTGGRPSPRAGNEAGTARS"
     gene            complement(9101..9235)
                     /gene="amiA"
                     /locus_tag="I6J40_RS36555"
     CDS             complement(9101..9235)
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="I6J40_RS36555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_006129278.1"
                     /transl_table=11
                     /translation="MEQNKVFSPIADQGQLAHLSATHSNALVENPFDDAVEADTAAEK"
     misc_feature    9214..9228
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.28"
                     /tool="antismash"
     misc_feature    9303..9316
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.45"
                     /tool="antismash"
     misc_feature    complement(9303..9318)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.88"
                     /tool="antismash"
     gene            complement(9304..10215)
                     /locus_tag="I6J40_RS01375"
                     /old_locus_tag="I6J40_01375"
     CDS             complement(9304..10215)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955796.1"
                     /locus_tag="I6J40_RS01375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_01375"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_234356490.1"
                     /transl_table=11
                     /translation="MSDGGAGSVGASPVRPPRLPADPGAGGRGGPEVVRAEGLSFGYPG
                     RTVLRGVDLAVRAGELVALIGLNGCGKSTFLKLAAGLLTPSAGRVLLEGDDVARLSRRT
                     AARRVALLHQAAPPVPGLTVRQLVRQGRYAARGPLGMLREGDDEVTSRALADVGVTGWA
                     DRPVDALSGGERQRVRLAMALAQDARLLFLDEPTTYLDLRHQLEVLQTVVRLRAERRLT
                     VVMVLHDLNHAARFADRIVALRDGRVAADGAPAEVVTRRLLAEVLGVEGRVGIDGEGGW
                     PVCYPDHPLDAFQLLRNENHIH"
     gene            complement(10243..11238)
                     /locus_tag="I6J40_RS01380"
                     /old_locus_tag="I6J40_01380"
     CDS             complement(10243..11238)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512972.1"
                     /locus_tag="I6J40_RS01380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6J40_01380"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_030291915.1"
                     /transl_table=11
                     /translation="MGVLALLLAVVACAGLLAGRGVTPGGVRAVLLGTADDPTAEHIVL
                     QLRLPRLLVALVAGACLGVAGLVLQSALRNPLAGPEVTGVTPGAVLGAVAATGLGLAGW
                     DSPAAVVVAACLGGFAGAGLLWLLTGRDRGDPERTAVYGVLVSAVLAGLTAVVLLVAPG
                     ELGSVVQWLIGSTEGRVWQHWNLLWPWALLWGAAAWLLAGPLTLLRCGDEQASAAGLAT
                     GRGRGAALVCAVALTAGAVSAVGALGFVGLLVPHLALAVFGADLRVTLPGAALLGAVVV
                     AGADAAAQLLSRLLSSALDADRLTLPVGALTTCVGAGLLLAVARRRADER"
ORIGIN
        1 tcgctcagct cgccggccgt ggcgtcgggc gcgcccagcc ggaggttctc ggcgagcgtg
       61 ccgtggaaga gcggggcctc ctgtcccacc acggacacgg cggaacgcag atcgtcctcg
      121 gcgaggtcgc gcaggtcgag ggggcggccc ggttccgggg gcagcagttc gacggccccg
      181 tctgccgggt cccagtaccg cgcgaggagg tgggcgcagg tggacttgcc cgcaccggac
      241 gcaccgacga gggccaccgt ctcgcccggc cgcacggtca ggtcgacgcc gtccagcacg
      301 gcctctcccc cgtagtcgaa ccgtacgccg cgcaggcgca ggcccagcgg gcccggcggc
      361 agggggcgcg gggcggcggg cgcgggcgcg agggccgggg cgtgcacggc ggcccggaca
      421 cgtgcggcgg cggcgcgcag tccgcccgcc cggccgagcg aggccgccga ctccgcgacc
      481 ggggccagcg cgcccagggc tagggccatg gccgccgggg cccacgcccc gtccagccgt
      541 cccgcggacg cggcgtgcgc ggcggcggcc acgacgccga tgacggcggc gaccaccagg
      601 aggtcgcggg ccgcgcccgc cccggtctcc caggactgtt cggcccgctg ggcacgggcg
      661 agccggcgtc cggcggagcg gagccgggcc cgcctgcggt ccagtgcccc cgccatcagc
      721 agctcgcgca gcccgtcgac gctctccacg gtctcggccg agacctcggc gagcgcgcgc
      781 cgggtccggg ccccgcgctc ggcccgcccg cgtgcttcgg ccaggggcga ccaggcgagg
      841 agcagcgcgg cgggcaggac ggcgagcagg agccatggtc cgagcgcggc cagcacggcg
      901 gccgccgccg cgaacacgat tccggatgcg atgagttggg cgatggcgtg ggcgtagaag
      961 aactccagcg cctcgacgtc cccgagggcg gtggccgcca ggtcgccgct gcgccggccc
     1021 gcgatccggg cgggggcgct gcgggccagc ccgtcgaaga cccggacgcg cagttcggcc
     1081 agcacccggt aggcgaggtc gtgcgagagg tccatctcgc gccaggtggc cagcgcccgg
     1141 agcaggacga gcccgatgag gacggcgacg gttccggggg cgggcgggcg gtgctcggtg
     1201 acggcggtgc cgaccgtgta cgcggcaagg gcgacgaggg cgaccagggc cgcttggtcg
     1261 acgagggccg ccaggcaggt gcggagcacg gtggcgcggt gagcgccgag gaccgggagg
     1321 agcgagcgga gcgctccggg cgggacgtcg tggtccgggg tgacggcggg ggcggacgcg
     1381 ggtgggcggg cggggtcgga aggggcgagg tcggaagggg cgggggtggg cgcggggctg
     1441 gtggtcatgc ggcgcgttct tcctgtgggg tgcgtccggt cgcttcatgg gcggggtccg
     1501 gatcgtccgc tttccgggtg gtgggttcgg ccgcttcatg ggcgggtccc gggtcgtccg
     1561 cttcccgggt ggtgcgtccg gccgcgacga gggcggcata cacgccgccg cccgcaagca
     1621 acgtggcgtg gtcgccctcg gcggccaccc ggccggcgtc gaggacgacg atgtggtcgg
     1681 cgtggcgtac ggcgtcgagc cggtgggcga cgacgatgcg ggtgcggtcc cggccgaccg
     1741 ccgacaacgc gcggacgatc cgcgcctggc cgcgttcgtc gaccgcgctg gtggcctcgt
     1801 ccaggaccag gacgggggct tcggcgagca acgcccgtgc gagggcgatc cgttgacgct
     1861 gcccgccgga gagcgtggcg ccgcgttcac cgacgagcgt ggcgtagccg tccggaaggc
     1921 ggctgatctc gtcgtcgatc cccgcgtcgc gggcggcggc gcgcagttgc ccgtcggtgg
     1981 cggccgggcg ggctatgcgc aggttctcgg cgatggtggc gtggaagagg taggtctcct
     2041 gcgagaccac ggcgatgccc cggcgcagcg aggcgagggt gtaggccgcg gtgtcggtcc
     2101 cggcgacggt gacgatcccg ctgtccgggt cgcgttgccg gagcagcagg ctgaggaggg
     2161 tcgactttcc ggccccggac gggccgacga cggcggtggt gcgcccgggg gcggccgtga
     2221 aggcgacacc gtccagggca ggccgatcgc tccccggatg ggtgaagcgc acgttctcga
     2281 aacggacttc gggcggaccg tcccagagcg ccgtcccggt tccccggtcc ggcacggcgg
     2341 gttcggcggt acgcagggcg gcgatcccgt cggcggcgga gacaccgagg tagccggcgt
     2401 gccattcgcg ggagaggtcg cggacgggcc ggaagcactc ggaggcgagg aggagcagga
     2461 ggtaggtgcc ggtggcggcg gtggccccgg tggccgccga ggagcaggcc acgaggacgg
     2521 cggcgaccgt accgccctgg accgccaggt cggtgagacc ggtgtcgacg agggagaccc
     2581 gcagtttggc gacggtgctc cggtgcagag cggccgaccg cagctccagc cgttcccgaa
     2641 cgcgccccac cgcaccggcg gcccgcaggg tcggcattcc ctggagggcc tccagatagt
     2701 cggcggcgag cgcttcgtag gagtcccagt ggtccttgcc gcgccgtgcg agcagccggt
     2761 cccaccctcg tggccccaac agggccagca gcagggcgag tccgagggcg agtgccgcgt
     2821 acggggcgac gagggcgacg gcgaccagga gcgccggcgg caccaggcag gtgatgagcg
     2881 cctggggcag atagcgggag acgtacgcgt cgacgccctc gacgccgtcc acgagggtgg
     2941 cccggacggc tccggcccgt gcccccgtga cggcggtggg gccgagcgcc ccgagccgca
     3001 ccagcagcgt gtcgcggagc cgtactcgta cggcggcccc ggccgtgacg gcaatcatcc
     3061 gctgggcgcg gccgaggagg gcgcgggcca ggacgacggc gatgacggcc gtgagcaggg
     3121 gggcgaggtc cgccgtggcc ccttgggcga tccgggcgag cacgagggcg aggaggacgg
     3181 cttgggcgag gtgggtggcg gtgaccgccg cgagcagggc ggtggcgagg ccgagggggc
     3241 ggcgtgccgt gttcgcggcg cggaggagtt cggggtggag catcatgggc gttcttcctc
     3301 gccgggcggt gtggtgcggg ccgtggtgcc gggggcgggc gggtcggtgg agtgcggcgt
     3361 gggccgggtg gcgcgcgggg ctgcggtagg ggcggcaggg gctgtcgccg tacgggtggc
     3421 gggtggtgtc gtcgctttcg ccgggggtgc gccgagggcc aggccgtgga cgatccagtc
     3481 gcgtccgggc gcttcaccca acgccgctcc gaggtccgcc tgctgccagg agccgatggg
     3541 ccgggaccgc agccccaggg cggtcgcgtg ggtctgggcc aggccgatcg cgtatccggc
     3601 ggcgagatgg ccggtgcgga cctcggcggg cggggcgtca tcggggaggc cgtgcgcgag
     3661 gaggaccgcc cccgtcgtgc cgatccacgt ctgacgggcg gcccagtggg cgagggtggg
     3721 gcgtgcgtct ccgtgagcgt ggagaagaag gccgggtctc cccggcctcc ccgtgtacag
     3781 ggccggggca gcgcccccgg tcaccaccgt ccagtcgggc ccggccgggc ttgccgtccg
     3841 ggcggtggtg aggacactgg cgagcaactc cctttcaggc gggcggcgca ggtcgtcggg
     3901 cggcgcgctc cggcgggtcg tgagggtctt cccggtcacg ccttccgggc gggatgccgg
     3961 gtgccacgta ccggcgggac gagcgggagc ttgcgcgagg aggctcaaca ggcgctgtgt
     4021 gtagctgagt tcgtgggcct gggctatcgg ggggccgggg gcacgcaccg gtgctgatgc
     4081 tcgggcccgg gttgcccagg cgctcagtgg atcgatggtc cgcacggagc caccggtagg
     4141 cgtgaaccac actgcggcaa gaggcggttc gagttccgcc gcctgccatt cgctgtgccg
     4201 ggccggggcg cggggcagtc ctgccgcagc ggagagcagg gcgccgtcgg cgtcgaggca
     4261 gaccagcacg tcggcggtcg gcggaccggc ctgcgcgagc gccgcggcgg catggcccgc
     4321 gtcgagcagc agcagcggcc aggcccggtg accgtagtgg gcgaccgtac gggaagccgc
     4381 cacggtgagc acggccagcg cccccgcagg tacgccgtcc ggggccgggc cgcgcgggtg
     4441 ggcccggtgc gtgtgcgggt cgtacgcgta gcggcccggc ggcagtgagc accccgggcc
     4501 gacgagcagg tgggcccgga ccgggtgcag ggcccctgcc gagggaacgg gacgcagccg
     4561 cccggacgtt ccggcgggcg cggcaaggga gagcctcaac aggcgggcga ggtcgagcgg
     4621 ggcgtcgtga cggatggggg cggcgcccac cgcggcggag ccggtgacgg cggagccggg
     4681 gccggagtcg gtacgcgcac cggcggcggc cctcctccgg ggccccccga aggccgccgc
     4741 cgcgtcggtc cgccgccggc cgcgatcggt gagcggcagc ccggggccgc tccacggaaa
     4801 cgggcgctcc gggacgtacg gggagagcgc cggaacccgc ggcgagcggg catcggcgag
     4861 tgcccggccc aggcagtccg gcgcgccggc ggacgatccg gccggatcct tcgcggcgga
     4921 tccgcccggc ggctccgcgc gcggatctcg ggtggggacg gcggctcggt ccggtgcgtc
     4981 aggcatggca gcgcgctcct tcacatgtgc gggggcgggg cgagggtgaa gtcctcgggt
     5041 ccggtgggcg gttgcgagcg ccagccccgg tcgagcgcgg cgtccgcgaa gcgcgggcag
     5101 ccgaagtagc cgaaggccgc cggggcgttg gggacgagac cggagacgag gacccgggcg
     5161 accctcagcg aggtctcggc gacgtcctcc gtggtgaggt ccgccgtgat cacccggtgg
     5221 cctccggcgg cgagcgccgc gtcgagggcg gcccggctgc cgggttccac cgcggcgacc
     5281 gggacgaccc cgagggcggg cgcggtgaag cggcgggcga gcggggccat gcggtcgtcc
     5341 agccagacct ggacgtgggc gcccaggtcg cgtacggcgg cgaaatccgt tccgcagtcg
     5401 tcgagatagc gccggtccgc cctgtggtcc aggtagaggc cgcgggcgag catgccggcg
     5461 tcgatcgccc ggtacaccca tccgtcggcg tccaccgcgc cctgggtgaa gacccaggtg
     5521 tgcacggcct ccagcacggc cttgcgcgcc gcctccgccg ggtcgtaccg gcaggcgaac
     5581 ccggccgcgt atatgccgcg ttcgggatcg tgcacgagcg ccgccacgca gggggcgaac
     5641 tcggagggca tctccacgat gtgcacgtcc agcgcgcagc cggccaggtc atcggtgagc
     5701 ccggggacgg tcgcggggtc gatgccccgg gtgggcccgt ccaggtgcca ccacagctcg
     5761 agcgcgtcgc gttcgacgat ttcgaggagg ccgcgctcga cggcgtcgtc caggccctgc
     5821 ccggtcgcga tgcccgcgta gttcaggtgg tgggtgcggg gcagcgaacg caggtcgcct
     5881 tgacgccagt tgaggtgggt cagcgcgacg ggggcccagc agggccgccc gttctcggtg
     5941 gcgcgggtcc acagcgccgg tgtgtccggg gtgagttcgg cgtacgggaa acccgtgcgg
     6001 ccgtactgcc aggaggcgta cgtcggcagg gagccgggtc cgtagaggcg gtgcccctcg
     6061 gcggccagct cggcggcggt ggcccgccgg ggcgcccggg gatgcccggg cggcgggacg
     6121 cggttgccgc agtagcgctc caccgcctcc gcgacggcgg cgatccacgc gccctcgcgg
     6181 tcgccgaacg tcgtgccgag cgagacccgg tcggcgggcc aggcgccgag gcggcgggcg
     6241 tcggcgacgt cggcggtcat cgcggtgtag cggggcggtg ccccggtggg gtgctcgacg
     6301 ggtgcgacat cccggacgat tccgctgacg ggatcgacga gggcttcgac gggcagggtg
     6361 ccggccgacg gcccttcgcc gctgcgggtc gacggctctg cttcgctgcg ggtcagcggt
     6421 tctgttccgg tgcgggtcaa cggcatatct ccggtacggg ctcgacatag cggcgtcggg
     6481 cgacgacggg caggtggagg gcgctgcccc gggcgtgcac ggtgcggtgg gacggggcga
     6541 gccgggtggc ggtgacaggg tcctcgccgg tgtgcgggtt gcgggcgtgg gcggggaagt
     6601 ggtgtccggc gacctcggcc cgcaggcggg tcccggcggg aagacggcgg cccagcgtgc
     6661 cgagcggcac agtgatgtcc gccgcccggc cgggcgggtc ggtccggcgg acgatgccga
     6721 aggccagggg ctcggcgcgg ccggcggggt cgagcgtggt caggcggacg gcccagtcgg
     6781 ccgagggcgt gtcggccgtg acgtggagtc gggcgacggc cagcccggcg agatcgagcg
     6841 ggcggggcag gggcggcgag acgagcaggc accggtcggg ccgttcgcgg tctgccggga
     6901 cggtgaggtc gtcggagcgc acgggtcggt ccgggtgggc ggtgaattcc gcgccgtgga
     6961 gcagtcgcag tccggtgcgc gagccgaagg gccagcgcac cgccgcctcc ggtcgacacg
     7021 gctcggaggc gccgggcgcg gatgccgtcc cggtcacgcg gtgccaacgg ccgctgccgc
     7081 ccagggcgat gaccccgcgc ggccgtggat ccagtcgccc ggcgagcgcg gcccgggccc
     7141 accgtacgta cagcgcaccg aggttgacgt gcgcgcgggg cggtgcggcc gggtcggcgg
     7201 tgaggtggtg gccccacggg ccgagcagca gtcgggccgg tccgccccac ccgcgccaca
     7261 gcgcgacggt gtcgtcggcg aaggggtcgc gggtgccgcc caccgcgagc agcggcagcc
     7321 gcgacgagga gccggcatcg gccagtcggc cccggtcgcg gccggtccag agacagggcc
     7381 acgacggcag ttcgcgcccc agcccctcgg ccagccgctc cgccacgcga gtgacgggga
     7441 ggtgttcgag gaggcggggg tcgctcgcca gggcgcggct cagcgcgtcc ggctcggagt
     7501 cacggcggtc gccgtgggcg gcccaccagc cggcgcgggc ccagagccgt tccgggccgc
     7561 tgggctctcg cgccgtttcg acgagtccga gcgcgggaac ggcggcgatg acggcgtcgg
     7621 gaccgccgtc gcggtgggcc tctcccggcc gcgcacccgt gcgacgccgg tcgtcgggcc
     7681 cggtgagcgc ggggacgagg gcgcagtacg cggcgtacga ggctccggcc gcgacgacct
     7741 cgccgttgct ccacggctgg gagcgcaccc aggcgatggc ggcggttccg tccggcccct
     7801 cgtgctcccc gtagggctgc cactcccccg gcgaaccgtg gcggccacgc acgtcctggg
     7861 cgaggaccgc gtatccgtgc gccgcccagc cgcgcgactc ggcgcggtgg gcacccctcc
     7921 cgtagggggt tctgatgagg acggcggggc aggggcgggg gccgtccggc aggcagatgt
     7981 cggtggcgag cgcggtgccg tccggcgtgg ggacgtacac cgtacgggtc ttcatgagcg
     8041 ggccgtcccg gcctcgttcc cggcgcgcgg gctcgggcgg cccccggtgg gcagcggtgc
     8101 gacgtccggg acgggcagcg cggggtgctc ggtgacggtg aggtcgcgca ggtcgatacg
     8161 gcgcagccgc cgacggggcg gaaggccggc gcggcgcacc ggtccggagc cttcccgggc
     8221 ctccgcgtcc gcatgcgctt tcgcgcccgc ccaggcgatc aggtctgcgg tgagcagtgc
     8281 ggcgatcagc gcggcggagg cggccgtggg gtgtggtccg gtgtcggggg tgcggtgccc
     8341 ggcccagtac gcggcgagtt cccggtgggc cggggtggcc gcgagtctgc ggagccggac
     8401 gtggcgggag gagacgtctc cgggggcggc ggcgagaggc tcggtccaca catgggaccc
     8461 ctcgcggtgg cagcgcagcc aggcgacgcg atggtccggg agccggtcgg cggcattcca
     8521 gaccccttcg gccgcgggcg agtcgagaca ccacacgacc gcgacgcgcc cctccgcgtg
     8581 ctcgtcgtcc gggcccgcca gggcgagttc cgccacaccg tccggggtga tcgggcggac
     8641 ctccgcccct tccccgcgta cgcaacgggt caggggctcc gtcagcgcgg ggtcgcccag
     8701 gaggtgcacg acgcgaccgc tgagcggcgg ccggggcgag gaggccaccg cgtacccgtc
     8761 ggcctcgaac gcctcgatca gccggtggag acggtcgtcg tgcggatctc ccgaagccgc
     8821 ttccgcctgc ccggtgagcc ggcgcgccag gacgtcgccg tcgacgcctc cggtgtcgat
     8881 gcgcaggaac tccccttccg gagaacggag tacggggccg gcaccgggaa cggtgacgat
     8941 cccggcgccg ggagccagtc gactgcgggt cacgaatcct ccgaacggaa ggcggggcgg
     9001 ggagcggatg gagcggtgaa cgggacgggc ccgcccggga tctcaccggg cgggcccgcc
     9061 cgcactgtgc ggggaagctg ccgtcagcgg caggtctcgc ttacttctcg gccgcggtgt
     9121 cggcctcgac ggcgtcgtcg aaggggttct cgacgagggc gttcgagtgg gtggcggaga
     9181 ggtgggcgag ctggccctgg tcggcgatcg ggctgaacac cttgttctgc tccatgagtt
     9241 gaagcctcca ttcacatcgg atgggtgtcg ttcgcggcga tgttctctgc cgcaccacag
     9301 acactaatga atatgatttt cattccgcaa tagctggaac gcgtcgagag ggtgatctgg
     9361 gtaacagacg ggccacccgc cctcgccgtc gatccccacc cgcccctcca cgccgaggac
     9421 ttcggccagc agccgacgcg tcaccacctc cgcgggagcg ccgtccgcgg cgacgcgccc
     9481 gtcgcgcagg gcgacgatgc gatcggcgaa ccgggcggcg tggttgaggt cgtggagcac
     9541 catcaccacc gtcagccgac gttccgcgcg cagccgtacg accgtctgga gcacctccag
     9601 ttggtgacgc agatcgaggt acgtggtcgg ctcgtcgagg aacagcagcc gggcgtcctg
     9661 ggccagcgcc atggcgaggc gcacacgctg gcgctccccg ccggacagcg cgtccaccgg
     9721 gcggtcggcc cagccggtga cgcccacgtc cgcgagggcc cgcgaggtca cctcgtcatc
     9781 gccctcccgc aacatcccga gcggtccccg ggcggcgtag cgaccctggc gtacgagctg
     9841 gcgcaccgtc agccccggta ccggcggcgc cgcttgatga agcagcgcca cgcgtcgggc
     9901 ggcggtgcgg cgcgacagcc gcgccacgtc gtcgccctcc agcaggacgc gcccggcgct
     9961 cggcgtgagc agccccgcgg cgagtttgag gaaggtgctc ttcccgcagc cgttcagccc
    10021 gatcagggcg accagttcgc cggcccggac ggcgaggtcc accccgcgca gcaccgtgcg
    10081 tcccgggtag ccgaaggaca gcccctcggc gcggaccact tccgggccgc cccgtccacc
    10141 ggcccccgga tccgccggga gccggggcgg ccgcaccggg ctcgcaccga cgctcccggc
    10201 ccctccgtcg gacatgtcag cgttctccat ccgctctctc cctcatcgct cgtcggcccg
    10261 tcgtcgcgcc acggccagca gcagccccgc ccccacacag gtggtcaggg cgccgaccgg
    10321 caaggtcagc cggtcggcgt cgagggcact ggacagcagc cgggacagca gttgggcggc
    10381 cgcgtccgcg ccggccacca ccaccgcccc gagcagcgcc gcgcccggca gggtgacccg
    10441 caggtcggcc ccgaagacgg ccagtgccag atggggcacg agcagtccca cgaagccgag
    10501 cgcgcccacc gccgagacgg ccccggccgt cagggccacc gcgcacacga gcgccgcgcc
    10561 ccgcccccgg cccgtggcga gcccggccgc ggacgcctgc tcgtcaccgc agcgcagcag
    10621 cgtcagcgga ccggcgagca gccacgccgc cgcgccccag aggagcgccc acggccagag
    10681 cagattccag tgctgccaca cccggccctc ggtggatccg atcaaccact ggacgacgct
    10741 gccgagttca ccgggggcca ccaggaggac gacggcggtg agcccggcga gcaccgccga
    10801 gacgaggacc ccgtacacgg cggtccgctc ggggtcgccc cggtcccgcc cggtgagcag
    10861 ccagagcagc cccgctccgg cgaagccacc gaggcaggcc gccacgacca cggccgcggg
    10921 ggaatcccat cccgcgagac cgaggccggt cgcggccacc gcgccgagca ccgcgccggg
    10981 cgtgacgccg gtgacctcgg ggcccgccag cgggttgcgc agcgcggact ggagcaccag
    11041 gcccgcgacc cccaggcagg cgccggcgac cagcgccacc agcagccggg gcagccgcag
    11101 ctggagcacg atgtgttcgg ccgtcggatc gtcggcggtc ccgagcagca cggcccgtac
    11161 gccaccgggc gtgacgcccc ggcccgccag caggccggcg caggccacca cggcgagcag
    11221 cagggccaga acgcccatcc ggacgcccgg tgctcggagc gcccggagtg cgcggcgcgc
    11281 gcggtgccga gcacgggcgg gccgctcggt cagggtgtcg gagggggtca tcgttccgcc
    11341 ttccggagaa cggggg
//
