LOCUS       NZ_CP049945            22583 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces koyangensis strain SCSIO 5802 chromosome, complete
            genome.
ACCESSION   NZ_CP049945
VERSION     NZ_CP049945.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces koyangensis
  ORGANISM  Streptomyces koyangensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces
            aurantiacus group.
REFERENCE   1  (bases 1 to 6861301)
  AUTHORS   Ding,W.
  TITLE     Genome mining and metabolic profiling illuminate the polycyclic
            tetramate macrolactams from Streptomyces koyangensis SCSIO 5802
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6861301)
  AUTHORS   Ding,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-MAR-2020) Chinese Academy of Sciences, Key Laboratory
            of Tropical Marine Bio-resources and Ecology, No.164 Xingang west
            Road, Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016803985.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:33:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,078
            CDSs (total)                      :: 5,988
            Genes (coding)                    :: 5,861
            CDSs (with protein)               :: 5,861
            Genes (RNA)                       :: 90
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 127
            CDSs (without protein)            :: 127
            Pseudo Genes (ambiguous residues) :: 0 of 127
            Pseudo Genes (frameshifted)       :: 60 of 127
            Pseudo Genes (incomplete)         :: 90 of 127
            Pseudo Genes (internal stop)      :: 7 of 127
            Pseudo Genes (multiple problems)  :: 29 of 127
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:34:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6633148
            Orig. end                         :: 6655731
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP049945.1.
            Bacteria and source DNA available from Deep sea sediment.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22583
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="20"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22583
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22583
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12583](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12583
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    699..715
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 14.75"
                     /tool="antismash"
     gene            767..1744
                     /locus_tag="G9U55_RS29130"
                     /old_locus_tag="G9U55_29380"
     CDS             767..1744
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008415332.1"
                     /locus_tag="G9U55_RS29130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29380"
                     /product="hypothetical protein"
                     /protein_id="WP_225930537.1"
                     /transl_table=11
                     /translation="MALLRGAGSSLRRWIGRSTAEVDEDQGEPEIGRIREAAEAADWSA
                     VRDQLTERPESEDRTWLINAVAKTANVENWIPQAVEAEPGSALPLLVAGARHVNWAWEA
                     RTGARAEHVSREQFQVFHNRLRTAEKWLYAAAEREPEWVSPWYFLQMSGRGLQVGQTVA
                     RRRFEAAVRRHPHHLGAHQQQLQQLCDKWGGSHEEMHAFATQAVREAPAGSMLGQLVAL
                     AHIEQWLALDSGADAEYLGQPGITASLTEAAERSIWHEDFAYGQGWLQVYNTFAMAFSL
                     TGDRDLAKLCFDGTNGIVTAFPWNYLDAADPAAAYRENRAAAGR"
     gene            1878..3728
                     /locus_tag="G9U55_RS29135"
                     /old_locus_tag="G9U55_29385"
     CDS             1878..3728
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0051082 - unfolded protein binding
                     [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894516.1"
                     /locus_tag="G9U55_RS29135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29385"
                     /product="HSP90 family protein"
                     /protein_id="WP_203216371.1"
                     /transl_table=11
                     /translation="MLHSESSHSFQVDLRGLVDLLSHHLYSSPRVYLRELLQNAVDALT
                     ARQAADPGAPAAITVRTGETLTVTDTGIGLTEADVHRFLATIGRSSKRNADGGLDGAGV
                     ESARGEFIGQFGIGLLACFVVADEITVVSRHATDPGAPTVEWRGHSDGRYTIRTLPASA
                     MPEPGTTVRLTPRADNAEWTAPERVTELARHFGGLLKYEVTVVDPRGTATRVNDTPPWE
                     RPHGSPLARREALTAYCRTTFDFTPLDTIELDLPAAGLRGVAYVLPTAVSPAQRAGHRV
                     HLKGMLLTDKAPELLPDWAFFVRCVVDTTSLRPTASREALYEDGTLAAVRDALGRRIRD
                     WLTGLAASDPALLHRFIDTHHLAVKALARYDDELLRVVLPWLPFETTDGNVTLEEFART
                     HPTVLVTRSVEEFRQVAPIASAAGLGVVNGGYTYDRDLVHRLPEIRPGSSVADLDPATV
                     TAHLDAVDPSAELRAAAFLALARETVGAHDCDVVLRDFQPVTAPALLLDNREARHERTR
                     SSLASESDGLWADILGSLRDETPRAQLVLNHLNPLVRQALTITERGLATTAAEALYGQA
                     LLLSRRPLRASESALLNRAFIGLLTHAMHPAGPAEPRKDA"
     gene            3729..6737
                     /locus_tag="G9U55_RS29140"
                     /old_locus_tag="G9U55_29390"
     CDS             3729..6737
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894517.1"
                     /locus_tag="G9U55_RS29140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29390"
                     /product="hypothetical protein"
                     /protein_id="WP_203216372.1"
                     /transl_table=11
                     /translation="MLDTPQAVLDALRENDGRPHGLHRTVTAEELAAAAEAFDDPALLV
                     TALLELMAAYEFTGEHRKSPVVFARLLKLHETSPDAFSEWEAHQVDWRFKWVTTSLLQV
                     PDMPLTTVHGWIDRMRERYEDAGHGLQPVAAMRYHLALHTGTGIPDAYDLWATRTRTRL
                     SDCEACETRHHALHQVFVGDDAGALDTWRPVLEGAVSCSDEPQMTQAHALLPLLRLGRA
                     DEARSHHLTGYRQVRGRTGMQEEVGLHLEFCALSRNAARGVEILAENRPLFEATGAPLA
                     RLGFLTGTEVLLALLVEEGHTDAPVGGPPGRNWTAGELLAEVRGEADRLAAAFDTRNGT
                     TAVGDARRLRLDRRPLLDEPLPLGLRTALTGPAAVPAPAPAPAPAREIPEDFTELVREA
                     RRMAAVGHPGDTPLWDRVAELAEAEGYAHDTALGPEARLRAELAEQRAHALYAEDRDRS
                     ARTAMEETAGLYEAAGMAWHALVARTRALSWDVVITDGEKGGEDSGAARSAGPALWEAL
                     DAFHREAEQLLEKRIAAHDETGADPGPLPATGPAPGSATAEKYLTVLHCRVFAAYHVAL
                     AGAPEIPAPDRERFETLRATLDSEAGRLGVPHQRGAARMFAGDVAARLGDHAVAETELR
                     AALEEIEASGRPWRGTRVRALLAQVLLCLDKPEEAADQLHQALAEAVRYEDTLFPMAPT
                     YLLLGHAGTHTGDLTGAVRHFSEAATRFDREGEPNDAADARLQLADLLARTGREADAVA
                     VLESVVGDDSAAALDERLLAQTRLTLARGLRGLGEHLPAAEEFLRLADTVAGWEDGAQT
                     LTLVAAEAATSLALAGRWEAARTAYDRAFAAHAEAPNPPMLLETACEFARLTMDAHGAE
                     AAEEALRRLADADALYAAVPEDDEEFVHWFARGSIHYRRARVLAQADRFAEALPEAEAA
                     VAAFADGGADGEERRAEAVRIAALIESHGLGRTQAAVARLDEAAARCERAGLSEAAQIL
                     TAVREDLAAGAGD"
     gene            6893..7876
                     /locus_tag="G9U55_RS29145"
                     /old_locus_tag="G9U55_29395"
     CDS             6893..7876
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894518.1"
                     /locus_tag="G9U55_RS29145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29395"
                     /product="ferric reductase-like transmembrane
                     domain-containing protein"
                     /protein_id="WP_203216373.1"
                     /transl_table=11
                     /translation="MQRPATPVPQEPGQAPEVAGRREGTPRLRGDLRAAVPDASAAIGV
                     TAAVFAFLWYRMEAGTSSTVAVMPFMDDPRAYWMYLLSQALGWSALLWAWGTVMLGLVL
                     SGPRTARQPPRRTLERWHRTTSLTTTALMFAHALMFAAELVRHDTRPAWLTRLWSAFAD
                     SFVPGWYDSGTGQIAIPVGQAALYLAVPLGLLFYVRHRIGPRTWRRLHRFVLVVYVLSV
                     WHTLLYGTNVWYGEWPRTVLWLLQIPVALLLVVRLARPARLAERLGAPGRPGGPRLPEW
                     TARALGRLAAAAVVAGLLAVVVSGHDGGRTRPADPPASTPHDHGSG"
     gene            7983..9311
                     /locus_tag="G9U55_RS29150"
                     /old_locus_tag="G9U55_29400"
     CDS             7983..9311
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640258.1"
                     /locus_tag="G9U55_RS29150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29400"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_203216374.1"
                     /transl_table=11
                     /translation="MAGETEFPEGARADGLPAALSDPARLAAVRGTGLLDTGPEPVFED
                     LATLAARITGAGRAFVTLVDEERSYWKSCVGVDVTGGRENPVRESFCYFLVGFGGDPFM
                     VEDAAHDPRTRDHPSIGPMKIGAWAGYPLLGPEGEVLGSFCVVDESPRAWTEADRATLA
                     TLSRSASAEIHLRQSLAASQHAHRLSADLAHTLQRGLLPPALRPVPGLDAAAAYVPASA
                     SAHHDVTVGGDFYDLFHAAGPYYGAFLGDVCGKGVEAAQVTSMARYTLRADAAEVLSPA
                     RLLTRLNTAMLTQEAPLFLTAVHATFRRTRAGAAGRVCLAGHPRPLVRRADGRVREVGR
                     PGTLLGVMEDVDLADTRFRLGPGDLLLLYSDGAYEARPAPGAPPEAAREPFGEADLHAT
                     LAATHGLDAAATVDRITGALAGHHGGWASDDTALLALRVPERD"
     gene            9378..10004
                     /locus_tag="G9U55_RS29155"
                     /old_locus_tag="G9U55_29405"
     CDS             9378..10004
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468731.1"
                     /locus_tag="G9U55_RS29155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29405"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_203216375.1"
                     /transl_table=11
                     /translation="MTTTPVLRLRDVHKRYGPRTVLSGADLDAAPGRLIGVVGENGAGK
                     STLLRILAGELRADRGTVRLPATVGHCPQTVVLHHALTVAQHLRYFQVAYGLPEPTRAW
                     ELLEELRFAAGPRDRTGTLSGGTRQKLNLAVALMHDPELLLLDEPYQGFDWETYLRFWE
                     IARSLCDRGRTVLVVSHMAHDTERLDALHRLADGRLTPVRDGGRA"
     gene            10001..12583
                     /gene="uppS"
                     /locus_tag="G9U55_RS29160"
                     /old_locus_tag="G9U55_29410"
     CDS             10001..12583
                     /EC_number="2.5.1.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="uppS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894521.1"
                     /locus_tag="G9U55_RS29160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29410"
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="WP_203216376.1"
                     /sec_met_domain="phytoene_synt (E-value: 7e-29, bitscore:
                     99.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.7e-20,
                     bitscore: 71.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRLRLCLTTALRYAVLEQVRNRLALALAVFFVPVWVGLAYTAMP
                     TAPVRFFLRAADQDVTVAGNVLTQLSGAVHALALIVGFMMFLAARRSAAFDHRLVTAGY
                     PRACLVLAKYLALLLACLLVAGYATAWICVFWRPEQPALLAAALGAGALTYGGAGIMLA
                     ALLRSELAGMFLVIMASFVDVSLQNPIANAGADSPVLRWLPTYGAMQSAVVAADTPHLP
                     WTHLGLALLWALTTAAVGTAAFTLHTRSRLGTPRRTWRPPPPRHRAYRQAGVDDPELRA
                     GYETCRRLVRRSGQTDYAVTQLVPAPLRPLLWAMYGHGRVLDDLSDSGHADAAERIDAW
                     VRAMEEDLARGTSTDPVRRALTHAVTTWDLPTEQLPASFATYRRDAAERPAFASWKQWH
                     AYWHALSFPVGVTRLATLLGEATGTRLGPRDAEALRLWTDAFNLVDALRDLRQDAHLGR
                     VAIPLPVLAAHGVHPADLREGRRTPQLDALVRELAVTAHGWLDTAAGLADRHPALAASW
                     RTLIRLQRLQLRALERGRPHSGGRRGPGSLRRALVLHTGRLRAALYWRRLGPALTPPQG
                     APVPAPPPTATPAVPRPRSAEPPLPPRPHAGGARPPAGLGDRVPRHVAIIMDGNGRWAA
                     ERGLPRPRGHRAGQAALRDVVYGALELGIPHLTLYGLSTENWKRPAAEVEEILRLLGEG
                     ADADREEVFARDVRLWWSGLPEGLPAGLLDALERTVRRTSHRRGLTLTLCVNYGGRAKL
                     TAAARELARDVAGGGLHPAAVTAPLFARYLHQPALPDVDLLIRTGGDHRLSNFLPWQAA
                     YAELVFLDTLWPDLDRTGLWRAVETYARRERRFGGLGEAAAQGRIEST"
     gene            complement(12559..13353)
                     /locus_tag="G9U55_RS29165"
                     /old_locus_tag="G9U55_29415"
     CDS             complement(12559..13353)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (8-123). E-value: 1.6e-07. Score:
                     23.4. Matches aSDomain:
                     nrpspksdomains_G9U55_RS29165_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640254.1"
                     /locus_tag="G9U55_RS29165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29415"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_101277894.1"
                     /transl_table=11
                     /translation="MQISLDGRTALVTGSTQGIGAAIAAGLAGAGARVAVNGRDAVRTE
                     EAVERLRREVPGGELFSAPGDLATDEGLAEVLDRLPQTDILVNSLGIFGARPALEIDDA
                     EWRRYFEVNVLTAVRLIRAYLPDMKERGWGRVLNIASDSAVVIPAEMIQYGMSKTALLA
                     VSRGFAKEAAGTGVTVNSVIAGPTHTGGVEEFVYDLVDKDLPWDEAQRAFMREYRPQSL
                     IQRLIEPEEIAHLVVYLSSPLASATTGGAVRVDGGYVDSILP"
     aSDomain        complement(12985..13329)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G9U55_RS29165_PKS_KR.1"
                     /evalue="1.60E-07"
                     /label="G9U55_RS29165_PKS_KR.1"
                     /locus_tag="G9U55_RS29165"
                     /protein_end="123"
                     /protein_start="8"
                     /score="23.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TALVTGSTQGIGAAIAAGLAGAGARVAVNGRDAVRTEEAVERLRR
                     EVPGGELFSAPGDLATDEGLAEVLDRLPQTDILVNSLGIFGARPALEIDDAEWRRYFEV
                     NVLTAVRLIRA"
     CDS_motif       complement(13237..13323)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_G9U55_RS29165_0001"
                     /evalue="5.00E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="G9U55_RS29165"
                     /protein_end="39"
                     /protein_start="10"
                     /score="12.8"
                     /tool="antismash"
                     /translation="LVTGSTQGIGAAIAAGLAGAGARVAVNGR"
     misc_feature    complement(13469..13483)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            complement(13529..14299)
                     /locus_tag="G9U55_RS29170"
                     /old_locus_tag="G9U55_29420"
     CDS             complement(13529..14299)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409383.1"
                     /locus_tag="G9U55_RS29170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29420"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_203216377.1"
                     /transl_table=11
                     /translation="MVSAPGAAAGALAGGALAVAAWHIGPAATWLPGLRTAYCPGLDGR
                     GSPGRVALTFDDGPDPLSTPHFLRALDALSVRATFFVLGSRLERAPELGRRMAAAGHEV
                     AVHGWEHDRPWLPRPGRDAAELARAAASVQRITGQRPLWYRPPYGILTGGRWAAARRTG
                     LRPVLWSAWGRDWTASATPDGVVAEAASRLGPGGTLLLHDSDAYAAPGSWRVTLAALPR
                     LVAYCRGLGLEVGTLGDHGHPGSGVPYGFPGPVG"
     gene            complement(14293..15174)
                     /locus_tag="G9U55_RS29175"
                     /old_locus_tag="G9U55_29425"
     CDS             complement(14293..15174)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468727.1"
                     /locus_tag="G9U55_RS29175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29425"
                     /product="DMT family transporter"
                     /protein_id="WP_203216378.1"
                     /transl_table=11
                     /translation="MTVLTVVLALLAALGNAAASVLQRRGTTQVDGGGAAVARWWSWAT
                     RLLRRRVWLWGAALLAVSGLCQAAALAAGPLAVVQPVMTTELLFTMVIGSAVFRRRPDV
                     RTWWAFVAMAAGLGAFMALLSPTGGGSTVPGSRWLWSGVLLAALMVVLTVVAWRLPPAP
                     AAAVLGTATAIGFAGTAALVKDALGRLPDGGLGALATTWQAYAAVVVGLGSFLLLQLTL
                     RAGPLVASQPAMTLGDAFLSMLLGRLLFGEDLTLGVRLVPELLALALLIAGTVQLARSP
                     LLTSTDGKERPW"
     gene            complement(15190..15981)
                     /locus_tag="G9U55_RS29180"
                     /old_locus_tag="G9U55_29430"
     CDS             complement(15190..15981)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (13-177). E-value: 2.2e-17.
                     Score: 55.5. Matches aSDomain:
                     nrpspksdomains_G9U55_RS29180_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409381.1"
                     /locus_tag="G9U55_RS29180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29430"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_129846943.1"
                     /sec_met_domain="adh_short (E-value: 3e-31, bitscore:
                     107.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRPGPGAVPRRTVLVTGASSGIGAAVAESLHADGRWRLLLSGR
                     DGERLAAVAERTGGEAIRADLAAEGGCERLADEAVARAGRVDALVAGAGIGWAGPFVTM
                     PPEEIDRVLTVNLTSTLRLVRLLLPPMVARGTGRLVLIGSMAGWVGVGDEAVYSASKGA
                     LLTFADSLRRELAGTRVRVSVVSPGAVDTPFFARRGTPYHRRRPRPVSAERVARGVREA
                     LVRGRENVLVPGWLALPARLHGAAPGLFGAVADRADPHRGD"
     aSDomain        complement(15451..15942)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G9U55_RS29180_PKS_KR.1"
                     /evalue="2.20E-17"
                     /label="G9U55_RS29180_PKS_KR.1"
                     /locus_tag="G9U55_RS29180"
                     /protein_end="177"
                     /protein_start="13"
                     /score="55.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVLVTGASSGIGAAVAESLHADGRWRLLLSGRDGERLAAVAERTG
                     GEAIRADLAAEGGCERLADEAVARAGRVDALVAGAGIGWAGPFVTMPPEEIDRVLTVNL
                     TSTLRLVRLLLPPMVARGTGRLVLIGSMAGWVGVGDEAVYSASKGALLTFADSLRRELA
                     G"
     CDS_motif       complement(15532..15564)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_G9U55_RS29180_0002"
                     /evalue="2.40E+00"
                     /label="PKSI-ER_m5"
                     /locus_tag="G9U55_RS29180"
                     /protein_end="150"
                     /protein_start="139"
                     /score="1.3"
                     /tool="antismash"
                     /translation="VLIGSMAGWVG"
     CDS_motif       complement(15847..15942)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_G9U55_RS29180_0001"
                     /evalue="5.90E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="G9U55_RS29180"
                     /protein_end="45"
                     /protein_start="13"
                     /score="15.7"
                     /tool="antismash"
                     /translation="TVLVTGASSGIGAAVAESLHADGRWRLLLSGR"
     gene            16178..17248
                     /locus_tag="G9U55_RS29185"
                     /old_locus_tag="G9U55_29435"
     CDS             16178..17248
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409380.1"
                     /locus_tag="G9U55_RS29185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29435"
                     /product="MGDG synthase family glycosyltransferase"
                     /protein_id="WP_203216379.1"
                     /transl_table=11
                     /translation="MGSLRVLLLGASMGAGHDAVSGELARRLRARGATTELCDVLTLLP
                     PGTGTALRGFYRGTVRHAPALYAAIYALFLSPGDGHRPGSAPLAATARARLLRRVHAFR
                     PDLLVPTFHLAAQITGRLRAEGVLPVPASVFVTDFAVHRGWLHPGNDLYVCLTGQGAEA
                     ARAATGRPAAVSGPVVAPEFHQVAGPHPHDPEPGPPPVLLSTGAWGVGTRTVRTARLLA
                     AHGCRPVLLCGRDERLRRRAARVPGAVALGWTDDMAGLMGAARLLVDNAAGQTAAQALA
                     AGVPVLDWRPLPGHGRDGARSMAAAGLSTYAHDTDDLLAAVRRLLRPGPARTGQVERGR
                     AAFVADAAELLTRPVG"
     gene            17332..18264
                     /locus_tag="G9U55_RS29190"
                     /old_locus_tag="G9U55_29440"
     CDS             17332..18264
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (17-307). E-value: 6.9e-54.
                     Score: 175.0. Matches aSDomain:
                     nrpspksdomains_G9U55_RS29190_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237538.1"
                     /locus_tag="G9U55_RS29190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29440"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_203216745.1"
                     /sec_met_domain="ADH_N (E-value: 5e-08, bitscore: 31.2,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.8e-19, bitscore:
                     68.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAIIQESYGGPEVLHETRVPRPEPGPGEILVAVRAAGVNPTDWK
                     HRARAGFVDRLPLILGWDVSGVVEAVGYGVALFAPGEEVFGMLPYPHGSGSHAEYVVGP
                     ARAFTRKPTVIDHVQAGALPLVSLTAYQALIDTAGIGPGQRVLIHAAAGGVGHVAVQIA
                     KAHGAYVIGTASAPKHDLLRELGADEVVDYRTTDVAEAVDGVDMVLDPLGGETRARSVG
                     LLRPGGTLVSLLSGGSPEEAARAAERGVRTATMLVEADHAGMNAVADLVAAGALRPRVE
                     ATFPLAEAAAAHTLGETGRTTGKIVLEVA"
     aSDomain        17383..18252
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G9U55_RS29190_PKS_ER.1"
                     /evalue="6.90E-54"
                     /label="G9U55_RS29190_PKS_ER.1"
                     /locus_tag="G9U55_RS29190"
                     /protein_end="307"
                     /protein_start="17"
                     /score="175.0"
                     /tool="antismash"
                     /translation="TRVPRPEPGPGEILVAVRAAGVNPTDWKHRARAGFVDRLPLILGW
                     DVSGVVEAVGYGVALFAPGEEVFGMLPYPHGSGSHAEYVVGPARAFTRKPTVIDHVQAG
                     ALPLVSLTAYQALIDTAGIGPGQRVLIHAAAGGVGHVAVQIAKAHGAYVIGTASAPKHD
                     LLRELGADEVVDYRTTDVAEAVDGVDMVLDPLGGETRARSVGLLRPGGTLVSLLSGGSP
                     EEAARAAERGVRTATMLVEADHAGMNAVADLVAAGALRPRVEATFPLAEAAAAHTLGET
                     GRTTGKIVL"
     CDS_motif       17758..17820
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_G9U55_RS29190_0001"
                     /evalue="1.70E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="G9U55_RS29190"
                     /protein_end="163"
                     /protein_start="142"
                     /score="26.8"
                     /tool="antismash"
                     /translation="GQRVLIHAAAGGVGHVAVQIA"
     gene            <18292..18963
                     /locus_tag="G9U55_RS29195"
                     /old_locus_tag="G9U55_29445"
                     /pseudo=""
     CDS             <18292..18963
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894526.1"
                     /locus_tag="G9U55_RS29195"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="G9U55_29445"
                     /product="aldo/keto reductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="GGGANEELLAEALHPCPDDLLIATKVGLARSAAGEWGHDALPEAL
                     RHQVEQALRRLRRDHTGFLQLDRIDPLGPARRPARHPAGAARGGQDRPHRALRGHRRRA
                     RRGAADHRDRGRAEPVQPAGPRARTRPRRLRVGGHRRPPEAAGRPGRLRRPRGGGRGRG
                     RTRRHRHPALPRLALLGHSPVILPIPGTADLAHLEENTAAGRLRLSDAHRARLDRLAAP
                     A"
     gene            complement(18977..19624)
                     /locus_tag="G9U55_RS29200"
                     /old_locus_tag="G9U55_29450"
     CDS             complement(18977..19624)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468722.1"
                     /locus_tag="G9U55_RS29200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29450"
                     /product="response regulator transcription factor"
                     /protein_id="WP_203216380.1"
                     /transl_table=11
                     /translation="MSLKVVVAEDSALMREGLVGVLTRFGHRVCAAVGDADALVVAAGE
                     HRPDLVLTDIRMPPGQGDDGLRAAVALRRDRPDLPILVLSQYLEQSYAAHLLDLGDQRG
                     IGYLLKDRVAAVTEFADTVVRVAGGGTVLDPEVVRQLLRRRQDPLNRLTPREREVLALM
                     AEGRSNAAIARALHVSVAAVNKHIGSILQRLGLPVDGDAHRRVLAVLAYLRN"
     gene            complement(19615..20820)
                     /locus_tag="G9U55_RS29205"
                     /old_locus_tag="G9U55_29455"
     CDS             complement(19615..20820)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640245.1"
                     /locus_tag="G9U55_RS29205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29455"
                     /product="sensor histidine kinase"
                     /protein_id="WP_203216381.1"
                     /transl_table=11
                     /translation="MHARTAWQALAHHPLAFLATLWPWRALAYLLSGVGVGALTLVVLV
                     SGLLTGLVLLPVGVGAAVLLAVVLGGGVVARVERWRLRLVDLDPAATDRRAPDAPGARA
                     WLRTRLRERLTWRELGFTAVSMTALWWMDLLVLAFALALPVLCVTAPLDDPGAWPWVVI
                     GLALLPAAPYTVTGWAGARAALTRLVLAPRDAELTEVRASRARLVGAFDAERRRIERDL
                     HDGAQQRLVSVNVLLGLARLDAGPDSPLGHQLDAIQGELTTAVGELRELSRGVHPRALT
                     DQGLAAALTNLTARSPLPVTVDVALPGPLPAPVASTAYFVVAEALANATKHSGAGRAEV
                     QARLRTDTLVLTVRDDGRGGADPAGRGLTGLADRVAAADGILRLSSPSGGPTLLHVEMP
                     CH"
     gene            20930..22471
                     /locus_tag="G9U55_RS29210"
                     /old_locus_tag="G9U55_29460"
     CDS             20930..22471
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468720.1"
                     /locus_tag="G9U55_RS29210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_29460"
                     /product="serine hydrolase"
                     /protein_id="WP_203216382.1"
                     /transl_table=11
                     /translation="MTTPQLRLRGRRSPLRVAVAVLLSAAPLLVPVPAQAAPREAPVLD
                     RATADRFVRDHLARTGVPGATVTVTRGDRVVLAAGYGHTAAGERMTARTPVPVASLSKA
                     MTALAVTTLAEEGRVDFDGPVHDQLPEFAPDDARAARITPRQLLDQTSGMADSAHPDLA
                     LPQPRTLKAAVAALRTTRLAADPGTAWHYHNTNYAVAARLVETATGTPYAEHLRRSLFA
                     PLGMTGTETVDTTADMPDGARGYVRAYGQTIERNHPRLFTAGGFGVVSTADDLGKWLIA
                     QHTEGTSATGRRAAPAAAVRLTRTPPSGQTYAMGWNRREEKGQPLRIEHTGSLFTHNSM
                     ATLLPASGVGIAVVTNTGMVSGDDAPLLVDGLVDLAEGRTPADRAPFTDTADPVLGGLS
                     LLALGLAVRGVLRAGRWARRPWRGPLRPALRLAPYLLPGLLLLGLADLFGLLMGRAGTL
                     AQITYVWPALFLWSATTALAATAVLAARCLALLRVRRGRAPGWPGRRRTARESDD"
ORIGIN
        1 cgtgccggac cgccgcccag cagcagcgcg gccaccacct cggcacggac cgtccgtccg
       61 gcgccccact ccgccccggt ggcgggatcg tcctcctcgg gcaccccggt ccgcaggtcc
      121 acccgccgtc cctcggggta ggcgtcccac aacgcacgct cggcggcggt cagttcgtcg
      181 tagatcagca cggccacagg gtacggcggc cgggcggccc accgccgggg aaaatcgtcg
      241 cgccggtggg gctgcccggc gcaccgtccc ttcctcgctc ctcgctcctc gcacgcggcg
      301 acggtggtgt tgcgggtgcc gccgcggtat gacgcgcgcg cccgtgccgc tcttacgtgg
      361 cgtcgttccg ccaggcgcgg cccggtgtat gtggtcgaga agtgaaggaa atgcgcgcgc
      421 ggctttgggt ggcacggccg gggatgccca gtcgcgccgt caggtgggga aagctgcagc
      481 tcaggggtgg tgtggtcggg cggtcctgga ggtggagcgc gcttatcggc ggtgtgccgt
      541 ggcggtgtcg agcattccgg atgtggcccg gtgcgggcga atcccggatg tgccgtcaca
      601 tttccgggga gcggaattcc gtatcgacaa gcagggtgaa tagggcccct cggcccacga
      661 acccgcacgt caaacgagtg tgcgggtgtc gtccgggcgt gatacttaac tacctgcgaa
      721 cgaggcgtcg acggtccgag gggaccgggc gcggcagggg gttgtcatgg cgttgctccg
      781 gggggcgggg tcctcgctga ggagatggat cggccgttcc accgccgagg tggacgagga
      841 ccagggggag cccgagatcg ggcgcatccg cgaggcggcc gaggccgccg actggtctgc
      901 cgtccgcgac cagctgacgg agcgtcccga gtccgaggac cgcacctggc tgatcaacgc
      961 ggtcgccaag accgccaacg tggagaactg gataccccag gccgtcgagg ccgagcccgg
     1021 ctcggccctg cccctgctcg tcgccggggc ccgccacgtc aactgggcct gggaggcacg
     1081 taccggcgcc cgcgccgagc acgtctcgcg cgagcagttc caggtcttcc acaaccggct
     1141 gcggaccgcc gagaagtggc tctacgcggc cgccgagcgc gagccggagt gggtcagccc
     1201 ctggtacttc ctccagatga gcggccgggg cctccaggtc gggcagaccg tcgcccgccg
     1261 ccgtttcgag gcggccgtgc ggcgccaccc gcaccacctc ggcgcccacc agcagcagct
     1321 ccagcagctc tgcgacaagt ggggcggctc ccacgaggag atgcacgcct tcgccaccca
     1381 ggctgtgcgc gaggcccccg ccggcagcat gctcggccag ctcgtcgccc tcgcccacat
     1441 cgagcagtgg ctcgccctcg actccggcgc cgacgccgag tacctggggc agcccggaat
     1501 caccgcctcg ctcaccgagg ccgccgaacg ctccatctgg cacgaggact tcgcctacgg
     1561 gcagggctgg ctccaggtgt acaacacctt cgccatggcc ttctcgctca ccggcgaccg
     1621 cgacctggcc aaactctgct tcgacggcac caacggcatc gtcaccgcgt tcccctggaa
     1681 ctacctcgac gccgccgacc cggccgccgc ctaccgcgag aaccgcgccg ccgccggccg
     1741 ctgagcccgc gcgcgtaccg ccgccgaacc aaccgcccgt gacgcgacgg gccccgccga
     1801 cagccggggc cccgccgggc ggctcatccc acccgcgcga cgccgcagcg gcgcgcgccc
     1861 gacgagggaa cccacaggtg ctccactccg agtcctccca cagcttccag gtcgacctgc
     1921 gtggtctggt ggacctgctc tcccaccacc tctactccag cccccgcgtc tacctgcgcg
     1981 aactcctcca gaacgcggtc gacgcgctca ccgcccggca ggccgccgac cccggcgccc
     2041 ccgccgccat caccgtgcgc accggcgaga cgctgaccgt caccgacacc ggcatcggcc
     2101 tcaccgaggc cgacgtgcac cgcttcctcg ccaccatcgg ccgcagctcc aagcggaacg
     2161 ccgacggcgg cctggacggc gccggagtgg agtccgcgcg cggggagttc atcggccagt
     2221 tcggcatcgg cctgctcgcc tgcttcgtcg tcgccgacga gatcaccgtg gtcagccggc
     2281 acgccaccga ccccggggcg cccaccgtcg aatggcgcgg ccactccgac ggccgctaca
     2341 ccatccgcac cctcccggcc tccgcgatgc ccgagccggg caccaccgtc cgcctcaccc
     2401 cgcgcgccga caacgccgag tggaccgccc ccgagcgggt caccgaactc gcccggcact
     2461 tcggcggcct gctgaagtac gaggtcaccg tcgtcgaccc gcgcggtacg gcgacccggg
     2521 tcaacgacac cccgccgtgg gagcgcccgc acggctcgcc gctggcccgc cgggaagcgc
     2581 tcaccgcgta ctgccgcacc accttcgact tcaccccgct cgacaccatc gaactggacc
     2641 tgcccgccgc cgggctgcgc ggcgtcgcct acgtcctgcc gaccgcggtc agccccgccc
     2701 agcgcgccgg ccaccgcgtc catctcaagg ggatgctcct caccgacaag gcgcccgaac
     2761 tcctccccga ctgggccttc ttcgtccgct gcgtcgtcga caccaccagc ctgcgcccca
     2821 ccgcctcccg cgaggcgctg tacgaggacg gcacgctggc cgccgtccgc gacgccctcg
     2881 gccggcgcat ccgcgactgg ctcaccggcc tcgccgccag cgaccccgcc ctcctccacc
     2941 gcttcatcga cacccaccac ctcgccgtca aggcgctcgc ccgctacgac gacgagctgt
     3001 tgcgggtcgt cctgccctgg ctgcccttcg agaccaccga cggcaacgtc accctcgaag
     3061 agttcgcccg cacccacccg accgtcctcg tcacccgcag cgtcgaggag ttccgccagg
     3121 tcgcgcccat cgcctcggcc gccggactcg gcgtcgtcaa cggcggctac acctacgacc
     3181 gcgacctcgt ccaccggctc cccgagatcc gccccggcag cagcgtcgcc gacctcgacc
     3241 cggccaccgt caccgcccac ctcgacgccg tcgacccctc ggccgaactc cgcgccgccg
     3301 ccttcctcgc cctggcccgc gagaccgtcg gcgcccacga ctgcgacgtg gtcctccgcg
     3361 acttccagcc ggtcaccgcg cccgccctgc tcctcgacaa ccgcgaggcc cgccacgaac
     3421 ggacccgctc ctcgctcgcc tcggagagcg acggcctgtg ggccgacatc ctcggctcgc
     3481 tgcgcgacga gacgccccgc gcccaactgg tcctcaacca cctcaacccg ctggtgcgcc
     3541 aggccctcac catcaccgag cgcggcctcg ccaccaccgc cgccgaagcc ctctacggcc
     3601 aggccctgct gctcagccgc cgcccgctca gggcgagcga gagcgccctg ctcaaccggg
     3661 ccttcatcgg cctgctcacc cacgccatgc acccggccgg cccggccgag ccccggaagg
     3721 acgcgtaaat gctggacacc ccgcaggcgg tgctcgacgc actgcgcgag aacgacggcc
     3781 gcccgcacgg tctgcaccgc accgtgaccg ccgaggaact ggccgcggcc gccgaggcgt
     3841 tcgacgaccc cgccctgctg gtcacggcgc tcctggagct gatggccgcc tacgagttca
     3901 ccggcgagca ccgcaagtcg ccggtggtct tcgcccggct gctgaagctg cacgagacct
     3961 cgcccgacgc cttcagcgag tgggaggccc accaggtcga ctggcggttc aagtgggtga
     4021 cgacctcgct gctccaggtc cccgacatgc cgctgaccac cgtccacggc tggatcgacc
     4081 ggatgcgcga gcggtacgag gacgccgggc acggcctcca gcccgtggcc gccatgcgct
     4141 accacctcgc cctgcacacc ggcaccggca tcccggacgc ctacgacctc tgggcgacca
     4201 ggacccgcac ccgcctcagc gactgcgagg cgtgcgagac ccgccaccac gcgctccacc
     4261 aggtcttcgt cggagacgac gcgggcgccc tcgacacctg gcgccccgtc ctggagggcg
     4321 ccgtcagctg ctccgacgag ccgcagatga cccaggcgca cgccctgctc ccgctgctgc
     4381 gcctcggccg ggcggacgag gcccgctcgc accacctcac cggctaccgg caggtccgcg
     4441 gccgcaccgg catgcaggag gaggtcggcc tccacctgga gttctgcgcg ctctcccgca
     4501 acgccgcgcg cggcgtggag atcctcgccg agaaccgccc cctcttcgag gccaccggcg
     4561 ccccgctggc ccgcctcggc ttcctcaccg gcaccgaggt gctgctcgcc ctgctcgtcg
     4621 aggagggcca cacggacgcg ccggtcggcg gtccgcccgg ccgcaactgg acggcgggcg
     4681 aactgctcgc cgaggtccgg ggggaggcgg accggctggc ggccgccttc gacacccgca
     4741 acggcaccac cgccgtcggc gacgcgcgcc gcctgcggct ggaccggcgc ccactgctcg
     4801 acgagccgct gccgctcggc ctgcgcaccg cgctcaccgg ccccgccgcc gtccccgctc
     4861 ccgccccggc acccgcaccc gcccgcgaga tccccgagga cttcaccgaa ctggtccgcg
     4921 aggcacgccg gatggctgcc gtgggccacc ccggcgacac cccgctgtgg gacagggtgg
     4981 ccgagctcgc ggaggccgag gggtacgccc acgacaccgc gctcggcccc gaggcccggc
     5041 tccgcgccga actcgccgaa cagcgcgccc acgccctcta cgccgaggac cgcgaccgga
     5101 gcgcgcggac cgcgatggag gagaccgccg ggctgtacga ggccgcgggc atggcctggc
     5161 acgccctggt cgcccggacc cgcgccctct cctgggacgt cgtcatcacc gacggcgaga
     5221 agggcgggga ggactccggc gcagcccggt ccgccggccc cgcactctgg gaggcgctcg
     5281 acgccttcca ccgggaggcg gaacagctcc tggagaagcg gatcgccgcc cacgacgaga
     5341 ccggcgccga ccccgggccg cttccggcca ccggccccgc ccccggctcg gccaccgccg
     5401 agaagtacct caccgtgctg cactgccggg tcttcgccgc ctaccacgtg gcgctggccg
     5461 gggccccgga gatccccgcg cccgaccgcg agcggttcga gacgctccgc gccaccctgg
     5521 acagcgaggc aggacggctc ggcgtgcccc accagcgcgg cgccgcccgc atgttcgccg
     5581 gggacgtcgc cgcccggctc ggcgaccacg ccgtggccga gacggaactg cgcgccgccc
     5641 tcgaagagat cgaggcctcc ggccgcccct ggcgcgggac ccgcgtccgg gctctgctcg
     5701 cccaggtcct gctctgcctc gacaagcccg aggaagccgc ggaccagctc caccaggcgc
     5761 tcgccgaggc ggtccggtac gaggacacgc tcttcccgat ggcccccacg tacctgctgc
     5821 tcggccacgc cgggacgcac accggcgacc tcaccggagc cgtacgccac ttctccgagg
     5881 cggccacccg cttcgaccgc gagggcgagc cgaacgacgc cgccgacgcc cggctccagc
     5941 tcgccgacct cctcgcccgc accggccgcg aggccgacgc ggtcgccgtc ctggagtccg
     6001 tcgtgggcga cgactcggcc gccgcactcg acgagcggct gctcgcccag acccgcctga
     6061 ccctcgcccg gggactgcgc gggctcgggg aacacctgcc cgccgccgag gagttcctgc
     6121 ggctggccga caccgtcgcc ggctgggagg acggcgcgca gaccctcacc ctggtcgccg
     6181 ccgaggccgc cacctcgctg gccctggccg gccgctggga ggcggcacgc accgcctacg
     6241 accgggcctt cgccgcgcac gccgaggcgc cgaacccgcc gatgctgctg gagacggcgt
     6301 gcgagttcgc gcgcctgacc atggacgcgc acggcgccga ggcggccgag gaggcgctgc
     6361 gccggctcgc cgacgccgac gccctgtacg cggccgtccc cgaggacgac gaggagttcg
     6421 tccactggtt cgcccggggc agcatccact accggcgcgc ccgcgtcctg gcccaggccg
     6481 accgcttcgc cgaggccctt cccgaggccg aggcggccgt cgccgccttc gccgacggag
     6541 gcgccgacgg tgaggagcgg cgcgccgagg ccgtccgcat cgccgccctg atcgagagcc
     6601 acggcctcgg ccgcacccag gcggcggtgg cccggctcga cgaggccgcc gcccggtgcg
     6661 agcgcgccgg cctgtccgag gcggcccaga tcctcaccgc cgtccgcgag gacctcgcgg
     6721 cgggcgccgg cgactgagcc ccggtccgcc gggacgggcg gcgcgtaccc cgcgccgccc
     6781 ctcccggcgg cctgatcatg tcggccggtt ctgctctcgg cagccggtgc gtgggccgcc
     6841 acactgtgca cgcgagtcac gccggttgcc cgccgcgagg aaaggccgac gtatgcagcg
     6901 ccccgccaca cccgtaccgc aggagccggg ccaggccccc gaggtggccg gccggcggga
     6961 ggggacgcct cgcctgaggg gcgatctgcg ggccgccgtc cccgacgcct ccgccgcgat
     7021 cggcgtcacc gccgccgtct tcgccttcct ctggtaccgc atggaggcgg gcacctcctc
     7081 gacggtcgcc gtgatgccgt tcatggacga cccgcgcgcc tactggatgt acctgctcag
     7141 ccaggcgttg ggctggtccg cgctgctctg ggcgtggggc accgtcatgc tcggcctggt
     7201 gctctccggc ccccggaccg cccggcagcc accccgccgc accctggaac gctggcaccg
     7261 caccaccagc ctcaccacca ccgcgctgat gttcgcgcac gccctgatgt tcgcggcgga
     7321 actggtccgc cacgacaccc gccccgcctg gctcacccgg ctctggtccg ccttcgccga
     7381 ctccttcgtg cccggctggt acgactccgg caccggccag atcgccatcc ccgtcggcca
     7441 ggccgccctc tacctcgccg tcccgctcgg cctgctcttc tacgtacgcc accgtatcgg
     7501 cccccgcacc tggcgccgcc tgcaccgctt cgtcctcgtc gtctacgtgc tcagcgtctg
     7561 gcacaccctg ctgtacggca ccaacgtctg gtacggcgaa tggccgcgca ccgtgctctg
     7621 gctcctccag atcccggtcg ccctcctcct cgtggtgcgc ctcgcccgcc cggcccgcct
     7681 cgccgaacgg ctcggcgccc ccggccgccc cggcggcccg aggctgccgg agtggaccgc
     7741 ccgcgcgctc gggcgcctcg cggccgccgc ggtcgtcgcc ggcctcctcg ccgtggtggt
     7801 cagcggtcac gacggcggcc gcacccgccc cgccgacccc ccggcgagca ccccgcacga
     7861 ccacggctcc gggtgagcga cgcgccgggg gagcggcccc cggcgccgct cgcggtggtg
     7921 gccccggcca gagccgccta gccttttcgt agagccgcag cggcgtggaa ggcaggggtc
     7981 gggtggccgg tgagaccgag tttcccgagg gtgcgcgggc ggacgggctg cccgccgcgc
     8041 tctccgaccc cgcacgcctg gcggcggtgc gcggcaccgg cctgctggac accggtcccg
     8101 agccggtctt cgaggacctg gccaccctcg ccgcccggat caccggcgcc ggacgcgcct
     8161 tcgtcaccct ggtcgacgag gaacgctcgt actggaagtc ctgcgtcggc gtcgacgtca
     8221 ccggcggccg ggagaacccg gtgcgggaga gcttctgcta cttcctcgtc ggattcggcg
     8281 gggacccgtt catggtcgag gacgccgcgc acgacccgcg cacccgcgac catcccagca
     8341 tcgggccgat gaagatcggc gcctgggccg gctatcccct gctcggcccc gagggcgagg
     8401 tgctcggcag cttctgcgtc gtcgacgagt cgccccgcgc ctggaccgag gcggaccggg
     8461 cgaccctcgc caccctctcc cgctccgcct ccgccgagat ccacctgcgg cagagcctcg
     8521 ccgcctccca gcacgcccac cgcctctccg ccgacctcgc ccacaccctc cagcggggtc
     8581 tgctcccgcc cgccctgcga cccgtccccg gcctcgacgc ggccgccgcc tacgtcccgg
     8641 cctccgccag cgcccaccac gacgtcaccg tcggcggcga cttctacgac ctcttccacg
     8701 ccgccggccc ctactacggc gccttcctcg gcgacgtctg cggcaagggc gtcgaagcgg
     8761 cccaggtcac ctccatggcc cgctacacgc tgcgcgccga cgccgccgag gtcctctccc
     8821 cggcgcggct gctgacccgc ctcaacaccg ccatgctcac ccaggaggcc ccgctcttcc
     8881 tgaccgccgt ccacgccacc ttccgccgta cccgcgccgg cgccgccgga cgcgtctgcc
     8941 tcgccggcca ccccaggccc ctggtccgcc gcgccgacgg ccgggtccgc gaggtgggcc
     9001 gccccggcac cctgctgggc gtcatggagg acgtggacct cgccgacacc cgcttccgcc
     9061 tgggccccgg ggacctgctg ctcctctact ccgacggcgc ctacgaggcc cgccccgccc
     9121 ccggcgcgcc ccccgaggcc gcccgcgagc ccttcggcga ggccgacctg cacgccaccc
     9181 tcgccgccac ccacggcctc gacgccgccg ccaccgtcga ccggatcacc ggcgccctcg
     9241 ccggccacca cggcggctgg gccagcgacg acaccgccct gctcgcgttg cgcgtgcccg
     9301 agcgcgactg accgcccgcg cccccacggc cttccgcacc acccgtacgg gagcccgctc
     9361 ggcctcgttc accggccatg acgaccacac ccgtgctgcg cctcagagac gtccacaaac
     9421 gttatggccc gcgcaccgtg ctgagcgggg ccgacctgga cgccgcgccc ggccggctga
     9481 tcggcgtggt cggggagaac ggcgcgggca agagcaccct gctccgcatc ctcgccggtg
     9541 aactgcgcgc cgaccggggg acggtgcgcc tccccgccac cgtcggacac tgcccccaga
     9601 ccgtggtcct gcaccacgcc ctcaccgtcg cccagcacct gcggtacttc caggtcgcct
     9661 acggcctgcc ggagcccacc cgcgcctggg aactcctgga ggaactgcgg ttcgccgccg
     9721 gcccccggga ccgcaccggc accctcagcg gcggcacccg ccagaaactc aaccttgccg
     9781 tcgccctcat gcacgacccg gaactcctcc tcctcgacga gccctaccag ggcttcgact
     9841 gggagaccta cctgcggttc tgggagatcg cccgctccct gtgcgaccgg ggccgcaccg
     9901 tcctggtcgt ctcccacatg gcgcacgaca ccgaacgcct cgacgccctc caccggctgg
     9961 ccgacggccg cctcaccccc gtccgcgacg ggggccgcgc atgacgcgcc tgcggctctg
    10021 cctcaccacg gccctgcggt acgccgtcct cgaacaggta cgcaaccggc tcgccctcgc
    10081 gctcgccgtc ttcttcgtcc ccgtctgggt cggcctcgcg tacaccgcca tgcccaccgc
    10141 gccggtgcgg ttcttcctgc gcgccgccga ccaggacgtc accgtcgccg ggaacgtcct
    10201 cacccagctc tccggcgccg tccacgcgct ggccctgatc gtcggcttca tgatgttcct
    10261 ggccgcgcgc cgctccgccg ccttcgacca ccgcctggtc accgccggtt acccgcgtgc
    10321 ctgcctggtc ctcgccaagt acctggccct gctgctcgcc tgcctcctcg tcgccggcta
    10381 cgccaccgcc tggatctgcg tcttctggcg ccccgagcag ccggcgctgc tggccgccgc
    10441 cctcggcgcg ggcgccctca cctacggcgg cgccggcatc atgctcgccg cgctgctccg
    10501 cagcgaactg gccgggatgt tcctggtcat catggccagc ttcgtcgacg tcagcctcca
    10561 gaacccgatc gccaacgccg gcgccgacag ccccgtcctg cgctggctgc ccacctacgg
    10621 cgccatgcag tccgccgtgg tcgccgccga caccccccac ctgccctgga cccacctcgg
    10681 cctcgccctg ctctgggccc tgaccaccgc cgccgtcggc acggccgcct tcaccctgca
    10741 cacccgcagc cgcctcggca cgccgcgccg cacctggcgc ccgcccccac cgcgccaccg
    10801 cgcctaccgg caggcgggcg tggacgaccc ggagctgcgc gccggttacg agacctgccg
    10861 ccgcctggta cgccgctccg gccagaccga ctacgccgtc acccagctcg tccccgcccc
    10921 gctgcggccg ctgctgtggg cgatgtacgg gcacggccgg gtcctggacg acctctccga
    10981 cagcggccac gccgacgccg ccgaacggat cgacgcctgg gtgcgggcga tggaggagga
    11041 cctcgcccgg ggcaccagca ccgacccggt gcgccgggcg ctgacccacg ccgtcaccac
    11101 ctgggacctg cccaccgagc agctgcccgc ctccttcgcc acctaccgcc gggacgccgc
    11161 cgaacggccc gccttcgcct cctggaaaca gtggcacgcc tactggcacg ccctcagctt
    11221 ccccgtcggc gtcacccgcc tcgcgaccct gctgggcgag gccaccggga cccgcctcgg
    11281 cccgcgcgac gccgaggcgc tgcggctgtg gaccgacgcc ttcaacctcg tcgacgccct
    11341 gcgcgacctg cgccaggacg cccacctggg ccgcgtcgcg atccccctcc cggtcctcgc
    11401 cgcccacggc gtgcaccccg ccgacctccg cgagggccgc cgaacgcccc aactcgacgc
    11461 cctggtgcgg gagctggccg tcaccgcgca cggctggctg gacaccgccg ccggcctcgc
    11521 cgaccgtcac cccgccctcg ccgcctcctg gcgcaccctc atccggctcc agcgcctcca
    11581 actgcgggcc ctggaacgcg gccgccccca ctccggcggc cgccggggcc ccggcagcct
    11641 ccgccgcgcc ctggtcctgc acaccggccg gctccgcgcc gccctgtact ggcggcgcct
    11701 cggccccgcc ctgacaccgc cgcaaggcgc acccgtcccc gcgcccccgc cgaccgccac
    11761 cccggccgtg ccgcgcccac gttccgccga acccccgctg ccgccgcgcc cgcacgccgg
    11821 tggggcgagg ccgccggccg ggctgggcga ccgggtgccc cggcacgtgg cgatcatcat
    11881 ggacggcaac ggccgctggg ccgccgagcg gggcctgccc cggccgcgcg gccaccgggc
    11941 gggccaggcg gcgctgcggg acgtggtcta cggggccctg gaactcggca tcccgcacct
    12001 gaccctgtac gggctctcca ccgagaactg gaagcgcccg gccgccgagg tggaggagat
    12061 cctccggctc ctgggcgaag gcgcggacgc cgaccgcgag gaggtcttcg cccgcgacgt
    12121 gcggctgtgg tggtccggtc tgcccgaggg gctgcccgcc gggctcctcg acgcactgga
    12181 gcgcacggtc cggcgcacca gccaccgcag gggcctgacg ctgaccctct gcgtcaacta
    12241 cggcggccgg gccaagctca ccgccgccgc ccgggagctc gcccgcgacg tggccggcgg
    12301 cggtctccac cccgccgccg tgacggcgcc gctcttcgcc cgctacctgc accagcccgc
    12361 gctgcccgac gtcgacctgc tgatccggac cggcggcgac caccgcctct ccaacttcct
    12421 gccctggcag gcggcctacg ccgagctggt cttcctcgac accctctggc ccgacctcga
    12481 ccgcaccggc ctgtggcggg ccgtggagac gtacgcccgc cgcgagcgcc gcttcggcgg
    12541 gctcggggag gcggctgctc agggcaggat cgagtccacg taaccgccgt ccacccggac
    12601 agcgccgccg gtcgtcgcgg aggccagcgg ggagctgagg tagacgacga ggtgggcgat
    12661 ctcctcgggc tcgatcagcc gctggatgag ggactgcggg cggtactcgc gcatgaaggc
    12721 gcgctgggcc tcgtcccagg ggaggtcctt gtcgaccagg tcgtagacga actcctccac
    12781 gccgccggtg tgggtggggc cggcgatcac cgagttgacg gtgacgccgg tccccgcggc
    12841 ctccttggcg aagccgcggg agaccgcgag cagggccgtc ttcgacatgc cgtactggat
    12901 catctcggcc gggatcacca ccgccgagtc gctggcgatg ttcaggaccc ggccccagcc
    12961 gcgctccttc atgtccggca ggtaggcgcg gatcagccgg acggccgtca gcacgttcac
    13021 ctcgaagtag cggcgccact cggcgtcgtc gatctccagc gcggggcgcg cgccgaagat
    13081 gccgaggctg ttgacgagga tgtcggtctg cggcagccgg tccagcacct cggccaggcc
    13141 ctcgtcggtg gccaggtccc cgggcgccga gaacagctcc ccgccgggca cctcgcgccg
    13201 cagccgctcg accgcctcct cggtgcgtac ggcgtcacgt ccgttgaccg cgacccgtgc
    13261 ccccgccccc gccaggccgg cggcgatcgc cgcgccgatg ccctgggtgg aaccggtgac
    13321 cagggcggtc ctgccgtcca gagagatctg catcctgctc ggaactcctc gcgtcgtcgg
    13381 tacggccggc actgcggacc ggcctcaccg cgcacccggc ggccgtcgcc gccgcgggca
    13441 acgcggtgcg ccgcatcgcc tgcccatcat ggccacccct gatacgccct gtcctgcggg
    13501 agggcgcaac gggagaccac ccccgccttc accccaccgg acccggaaag ccgtacggca
    13561 ccccgctccc cggatgcccg tggtccccga gcgtccccac ctccagcccg agcccccggc
    13621 agtacgcgac cagtcgcggc agcgccgcca gggtcacccg ccaggagccc ggagccgcgt
    13681 acgcgtccga gtcgtggagc agcagcgtgc cgccgggccc cagccgggag gcggcctcgg
    13741 cgacgacgcc gtccggggtc gcggaggcgg tccagtcgcg accccacgcc gaccacagca
    13801 ccggccgcag cccggtacgc cgggcggcgg cccagcgccc gccggtgagg atgccgtacg
    13861 gcggccggta ccagagcggc cgctgcccgg tgatgcgctg gacggaggcc gcggcccggg
    13921 ccagttccgc cgcgtcccgg cccggccggg gcagccaggg gcggtcgtgc tcccagccgt
    13981 gcaccgccac ctcgtgcccg gccgccgcca ttcgccggcc cagctccgga gcgcgctcca
    14041 gcctgctgcc gaggacgaag aaggtggccc gcaccgacaa ggcgtccagc gcccgcagga
    14101 agtgcggggt gctcagcggg tccggcccgt cgtcgaaggt gagcgccacc cggccgggcg
    14161 acccccgtcc gtcgagcccc gggcagtacg ccgtacggag accgggcagc caggtcgccg
    14221 ccgggccgat gtgccacgcg gcgacggcga gcgcaccccc ggccagcgcc ccggcggccg
    14281 cgcccggcgc gctcaccacg gccgctcctt gccgtcggtc gaggtcagca ggggggagcg
    14341 ggccagctgc acggtgcccg cgatgagcag cgcgagcgcc agcagttccg gcaccagccg
    14401 caccccgagg gtcagatcct cgccgaagag gagccggccc agcagcatgc tgaggaaggc
    14461 gtcgcccagc gtcatcgccg gctgcgaggc caccagcggc cccgcccgca gcgtgagttg
    14521 cagcagcagg aaactcccca gccccacgac gaccgccgcg tacgcctgcc aggtggtggc
    14581 cagtgccccc agcccgccgt ccggcagccg tcccagggcg tccttgacca gcgcggcggt
    14641 cccggcgaag ccgatcgcgg tggcggtgcc gaggaccgcg gcggccggtg cgggcggcag
    14701 ccgccaggcc accaccgtca gcaccaccat gagcgccgcc agcagcaccc ccgaccacag
    14761 ccaccgcgac cccggcaccg tcgagccgcc gccggtgggg gagagcaggg ccatgaacgc
    14821 gccgagcccg gccgccatcg cgacaaacgc ccaccaggtc ctgacgtccg gccggcggcg
    14881 gaagacggca ctgccgatga ccatggtgaa gaggagttcg gtggtcatca ccggttgcac
    14941 cacggcgagc ggaccggccg ccagcgccgc cgcctggcag agcccggaga ccgcgagcag
    15001 cgccgcgccc cacagccaca cccggcgccg gagcagccgc gtggcccacg accaccaccg
    15061 ggcgaccgcc gccccgccac cgtccacctg cgtggtgccg cggcgctgga gcaccgaggc
    15121 ggccgcgttg ccgagcgccg cgaggagcgc cagcaccacc gtcagtacgg tcaccggcgc
    15181 gcccccgcct cagtcaccgc ggtgcgggtc ggcacggtcg gccacggccc cgaacaggcc
    15241 cggcgccgcc ccgtgcagcc gcgccggaag cgccagccac cccggcacca ggacgttctc
    15301 ccggccccgt acgagcgcct cccgcacccc gcgcgccacc cgttcggccg agaccgggcg
    15361 gggacggcgc cggtggtacg gggtgccgcg ccgggcgaag aacggcgtgt ccaccgcgcc
    15421 cggcgacacc accgagacgc gtacccgggt cccggcaagc tcgcggcgca ggctgtccgc
    15481 gaaggtcagc agggcgccct tggacgccga gtagaccgcc tcgtccccca cccccaccca
    15541 gccggccatc gacccgatca gcaccagccg ccccgtgccg cgcgccacca tcgggggcag
    15601 cagcagccgg accagccgca gcgtggaggt gaggttgacg gtcaggaccc ggtcgatctc
    15661 ctccggcggc atcgtcacga acggacccgc ccagccgatc cccgccccgg ccaccagcgc
    15721 gtcgacgcga ccggcgcggg ccaccgcctc gtctgccagg cgctcgcagc ctccctcggc
    15781 cgccaggtcg gcgcggatcg cctccccgcc ggtccgctcc gcgaccgccg cgagccgctc
    15841 cccgtcgcgc ccgctgagca gcagccgcca ccggccgtcg gcgtgcaggg actcggccac
    15901 cgcggcgccg atgcccgagg aggcacccgt gaccagcacg gtccgccggg gcacggcccc
    15961 gggtccggga cgccgcgtca tgccgcccac tcctcgcaca tgccagtccc cttcctcgcg
    16021 gcacgcctgg ccctcagctt ccgtgctcgg cgggcggacc gctcgtccaa cgccggggca
    16081 cgccgccgcc gggtcacccg aacgggccga ttgcgccccc gcccggacgc ggcatgcaag
    16141 cgatggacga gtccaccggc cgggcgaggg gaggaacatg ggaagcctgc gggtcctgct
    16201 gctcggcgcg agcatgggcg ccgggcacga cgcggtcagc ggcgaactgg cccgcagact
    16261 ccgggcccgg ggcgccacca ccgaactctg cgacgtcctc accctcctgc cgcccggcac
    16321 ggggacggcc ctgcgcggct tctaccgggg gacggtgcgg cacgcccccg cgctgtacgc
    16381 cgcgatctac gcactcttcc tctccccggg cgacggacac cgccccggca gcgcccccct
    16441 ggccgcgacg gcccgcgccc ggctgctgcg ccgggtccac gccttccgcc cggacctgct
    16501 cgtccccacc ttccacctcg ccgcgcagat caccggcagg ctccgcgccg aaggcgtcct
    16561 gcccgtcccc gcctcggtct tcgtcaccga cttcgccgtc caccgcgggt ggctgcaccc
    16621 gggcaacgac ctctacgtct gcctcaccgg acagggcgcg gaggcggccc gtgccgccac
    16681 cggccgcccg gccgccgtct ccggaccggt tgtcgccccg gagttccacc aggtggcagg
    16741 cccgcacccg cacgatcccg aaccggggcc tccgcccgtc ctgctctcca ccggcgcctg
    16801 gggcgtcggc acccggaccg tgcgcaccgc ccggctcctc gccgcccacg gctgccggcc
    16861 cgtcctgctc tgcggccggg acgagcggct gcgtcgacgc gccgcccgtg tccccggcgc
    16921 cgtcgccctc ggctggacgg acgacatggc gggtttgatg ggcgccgccc ggctcctggt
    16981 cgacaacgcc gccgggcaga ccgcggccca ggccctcgcc gccggtgtgc ccgtcctcga
    17041 ctggcgaccg ctgcccggcc acggccgcga cggggcgcgg agcatggccg ccgccggact
    17101 cagcacgtac gcccacgaca cggacgacct gctcgcggcc gtccggcggc tgctccgccc
    17161 cggaccggcg cgcaccggcc aggtggagcg gggccgggcc gccttcgtgg cggacgccgc
    17221 ggaactcctc acccgtcccg tcggctgacc ggttcacccg ggcaccggcc cggcgtggtg
    17281 cggaacgcgg ccgtccgcga ggctggaccc atgacgcagg acgcagccac gatgcgcgcc
    17341 atcatccagg agagctacgg aggccccgag gtcctccacg agacccgggt accgaggccc
    17401 gagccgggac cgggggagat cctggtcgcc gtccgcgccg ccggggtcaa ccccaccgac
    17461 tggaagcacc gcgcgcgggc ggggttcgtc gaccgcctcc cgctcattct cggctgggac
    17521 gtctccgggg tggtggaggc cgtcggctac ggggtggccc tcttcgcacc cggcgaggag
    17581 gtcttcggca tgctgcccta cccgcacggc tccggctcgc acgccgagta cgtcgtcggg
    17641 cccgcccgcg ccttcacccg taagcccacg gtgatcgacc acgtccaggc gggcgcgctc
    17701 ccgctggtct ccctcaccgc ctaccaggca ctgatcgaca ccgccgggat cggccccgga
    17761 cagcgcgtcc tgatccacgc ggcggcgggc ggcgtcggcc atgtggccgt acagatcgcc
    17821 aaggcgcacg gcgcgtacgt catcggcacg gccagcgcgc ccaaacacga cctgctgcgc
    17881 gaactcggtg ccgacgaggt ggtcgactac cgcaccaccg acgtcgccga agcggtcgac
    17941 ggcgtcgaca tggtgctcga cccgctcggc ggcgagaccc gcgcccggtc ggtcggcctg
    18001 ctgcgccccg gcggcaccct ggtctccctg ctctccggcg gttcgcccga ggaggcggcg
    18061 cgcgccgccg agcggggcgt gcgcacggcg acgatgctgg tcgaggccga ccacgccggc
    18121 atgaacgccg tcgccgacct ggtcgccgcc ggggccctgc gtccgcgcgt cgaggcgacc
    18181 ttcccgctgg ccgaggcggc tgccgcccac acgctcggcg agaccgggcg gaccaccggg
    18241 aagatcgtcc tggaagtggc ctgagaagcc gcctccgtcc ccaactgggc cggcggtggc
    18301 gccaacgagg agctgctcgc cgaggccctg cacccctgcc ccgacgacct gctgatcgcc
    18361 accaaggtgg gcttggcccg ctcggcggcg ggggagtggg gccacgacgc cctgcccgag
    18421 gccctgcgcc accaggtcga gcaggcgctc cggcggctgc gccgcgacca caccggcttc
    18481 ctgcaactgg accgcatcga ccccctcggt cccgctcgcc gaccagctcg gcaccctgcg
    18541 ggagctgcgc gaggagggca ggaccggcca catcgggctc tccgaggtca ccgtcggcga
    18601 gctcgacgag gcgcggcgga tcaccgagat cgcgggcgtg cggaaccggt acaacctgct
    18661 ggaccgcgag cacgaacccg tcctcgccgc ctgcgagtcg gcgggcatcg ccgtcctccc
    18721 gaggcggccg gtcgcccggg gcggctccgg cgcccacgcg gaggtggccg cggtcgcgga
    18781 cgaactcggc gccaccgcca cccagctctc cctcgcctgg cgctcctcgg ccactccccg
    18841 gtgatcctcc cgatcccggg caccgccgac ctggcgcacc tggaggagaa caccgccgcc
    18901 ggccgactcc gcctgtccga cgcgcaccgg gcgcgcctgg accggctggc ggcgcccgcc
    18961 tgaccctggc gggaggtcag ttccgcaggt aggccagcac cgccaggacc cgccggtggg
    19021 cgtcaccgtc caccggcagg ccgaggcgtt gcaggatgct gccgatgtgc ttgttgaccg
    19081 cggccaccga gacgtgcagg gcgcgggcga tggccgcgtt ggaccggccc tcggccatca
    19141 gcgccagcac ctcccgctcc cggggcgtga gccggttcag cgggtcctgc cggcgccgca
    19201 gcaactgccg taccacctcc gggtccagca ccgtgccgcc gcccgccacc cggaccacgg
    19261 tgtccgcgaa ctcggtcacc gccgccaccc ggtccttcag caggtagccg atgccgcgct
    19321 ggtcgccgag gtcgagcagg tgggcggcgt aggactgctc caggtactgg ctgaggacga
    19381 gaattggcag gtccgggcgg tcgcggcgga gtgcgacggc ggcccgcagc ccgtcgtcac
    19441 cctggcccgg cggcatgcgg atgtcggtga ggacgaggtc ggggcggtgc tcgcccgccg
    19501 ccacgacgag ggcgtccgcg tcccccaccg ccgcgcacac ccggtggccg aagcgggtca
    19561 gcacgcccac caggccctcc cgcatcagcg ccgagtcctc ggcgaccacg accttcagtg
    19621 acacggcatc tccacgtgca gcagggtggg cccgccggac gggctggaca gccgcagtat
    19681 gccgtccgcc gccgccaccc ggtccgccag ccccgtcagc ccccgcccgg cggggtccgc
    19741 gccgccacgc ccgtcgtccc ggacggtgag caccagcgtg tcggtacgca gccgggcctg
    19801 gacctcggca cggccggcgc cgctgtgctt ggtcgcgttg gccagcgcct cggcgaccac
    19861 gaagtacgcg gtgctcgcga ccggcgcggg cagcggcccc ggcagagcca cgtcgacggt
    19921 gaccgggagc ggcgagcggg cggtgaggtt ggtgagggcc gccgcgagac cctggtcggt
    19981 cagggcgcgg gggtggacgc cccggctcag ctcgcgcagc tcaccgacgg ccgtcgtcaa
    20041 ctcgccctgt atggcgtcca gctgatggcc gaggggcgag tcgggtcccg cgtcgagccg
    20101 ggccagcccc agcagcacgt tgaccgacac cagccgctgc tgcgccccgt cgtgcagatc
    20161 ccgctcgatc cggcgccgct cggcgtcgaa cgccccgacc agccgggccc gcgaggcacg
    20221 gacctcggtc agctcggcgt ccctcggcgc cagcaccagc cgggtcagcg ccgcccgcgc
    20281 cccggcccag ccggtgacgg tgtacggcgc cgccggcagc agcgcgaggc cgatcaccac
    20341 ccagggccag gcgcccgggt cgtccagcgg cgccgtcacg cacagcaccg gcagcgccag
    20401 ggcgaaggcc aggacgagca ggtccatcca ccacagcgcg gtcatggaga ccgccgtgaa
    20461 ccccagctcc cgccaggtca gccgctcccg cagccgggtc cgcagccacg cccgcgcacc
    20521 gggcgcgtcc ggcgcccggc ggtccgtggc cgccgggtcg aggtccacca gccgcagccg
    20581 ccaccgctcg acccgcgcga ccacaccgcc accgaggacc acggcgagca ggacggccgc
    20641 ccctactccg accggcagca gcaccagccc cgtcagcaac ccgctcacca gcaccaccag
    20701 ggtgagcgcc ccgacgccca ccccggagag cagataggcc agggcacgcc acggccagag
    20761 agtggcgagg aaggcgagag ggtgatgggc cagggcctgc caggccgttc gcgcgtgcat
    20821 ggaccgacag tacggagccc gcgccgcccg gtcggtagtg cccgcactac cttttccgtc
    20881 cccgtgccac cactgcgccc ggccccccca ggccggttgg ctctcaggca tgaccactcc
    20941 tcaactccgt ctcaggggta ggcgttcgcc cctccgggtc gccgtagccg tcctgctgtc
    21001 cgccgcgccg ctcctcgtcc ctgttccggc ccaggcggcc ccgcgggagg cgcccgtact
    21061 cgaccgggcc accgccgacc ggttcgtccg cgaccacctg gcccgcacgg gggtccccgg
    21121 cgcgacggtc acggtgaccc ggggggaccg cgtcgtcctc gccgccgggt acgggcacac
    21181 cgcggcgggg gagcggatga cggcccggac gccggtcccg gtcgcctccc tgtcgaaggc
    21241 gatgacggcg ctggcggtga ccaccctcgc cgaggaaggc cgcgtcgact tcgacgggcc
    21301 cgtccacgac cagctccccg agttcgcccc cgacgacgcc cgcgccgccc ggatcacccc
    21361 gcgccaactc ctcgaccaga cctcggggat ggccgactcg gcccaccccg atctcgccct
    21421 cccgcaaccc cgcaccctga aagccgcggt cgccgccctc cgcaccaccc ggctcgccgc
    21481 cgaccccggc acggcctggc actaccacaa caccaactac gccgtagccg cgcgcctcgt
    21541 cgagaccgcc accggcaccc cgtacgccga acacctgcgc cggagtctgt tcgcgccgct
    21601 cgggatgacc ggcaccgaga ccgtcgacac cacggccgac atgcccgacg gcgcccgggg
    21661 gtacgtccgc gcctacgggc agacgatcga acgcaaccac ccccgccttt tcaccgccgg
    21721 tggcttcggt gtcgtcagca ccgccgacga cctggggaaa tggctgatcg cccagcacac
    21781 cgagggcacc tcggccaccg gccgccgcgc cgcccccgcc gcggcggtcc ggctcacccg
    21841 caccccgccg tccggccaga cgtacgcgat gggctggaac cggcgggagg agaaggggca
    21901 accgctgcgg atcgagcaca ccggcagcct cttcacccac aactccatgg ccaccctgct
    21961 gcccgcctcc ggcgtgggga tcgcggtggt caccaacacc ggcatggtct ccggggacga
    22021 cgccccgctc ctcgtcgacg gcctcgtcga cctcgccgaa ggcaggaccc cggcggaccg
    22081 cgctcccttc accgacaccg ccgacccggt cctcggcggc ctctccctgc tggccctcgg
    22141 acttgcggta cgcggcgtcc tgcgcgcggg acggtgggcc cgccgcccct ggcgtggacc
    22201 cctgcggccg gccctacgcc tcgccccgta cctcctcccg ggcctgctcc tcctcggact
    22261 cgcggacctc ttcgggctgc tgatgggccg cgcgggaacc ctggcgcaga tcacctacgt
    22321 ctggcccgcc ctcttcctgt ggtccgcgac gaccgcgctg gcggccacgg cggtactggc
    22381 ggcccgctgc ctcgctctcc tccgggtgcg gcggggccgg gcgcccgggt ggccggggcg
    22441 gcgccggacg gcacgtgaaa gcgatgactg aatagcctat atggtgaata tcgggcgata
    22501 tcgtgcaagc atggctcggg ggcgaaaagg ggagggcggc tgccgccgcc cctggcccgg
    22561 gccagagtta gcgcctccgc gtc
//
