LOCUS       NZ_CP049945            10216 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces koyangensis strain SCSIO 5802 chromosome, complete
            genome.
ACCESSION   NZ_CP049945
VERSION     NZ_CP049945.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces koyangensis
  ORGANISM  Streptomyces koyangensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces
            aurantiacus group.
REFERENCE   1  (bases 1 to 6861301)
  AUTHORS   Ding,W.
  TITLE     Genome mining and metabolic profiling illuminate the polycyclic
            tetramate macrolactams from Streptomyces koyangensis SCSIO 5802
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6861301)
  AUTHORS   Ding,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-MAR-2020) Chinese Academy of Sciences, Key Laboratory
            of Tropical Marine Bio-resources and Ecology, No.164 Xingang west
            Road, Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016803985.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:33:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,078
            CDSs (total)                      :: 5,988
            Genes (coding)                    :: 5,861
            CDSs (with protein)               :: 5,861
            Genes (RNA)                       :: 90
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 127
            CDSs (without protein)            :: 127
            Pseudo Genes (ambiguous residues) :: 0 of 127
            Pseudo Genes (frameshifted)       :: 60 of 127
            Pseudo Genes (incomplete)         :: 90 of 127
            Pseudo Genes (internal stop)      :: 7 of 127
            Pseudo Genes (multiple problems)  :: 29 of 127
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:34:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6243323
            Orig. end                         :: 6253539
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP049945.1.
            Bacteria and source DNA available from Deep sea sediment.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="17"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5216)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    1625..1637
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            complement(1687..3984)
                     /locus_tag="G9U55_RS27475"
                     /old_locus_tag="G9U55_27695"
     CDS             complement(1687..3984)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640763.1"
                     /locus_tag="G9U55_RS27475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_27695"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_101279492.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 9.6e-36, bitscore:
                     121.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPADAPAAGTGSTAPPTPGGRRGRRAAPSSGRRRAAPPRRTPR
                     RRPVRTPTVLQMEAVECGAACLAMVLAHHGRHVPLEELRIACGVSRDGSRASNVLKAAR
                     SYGLTAKGMQMEPAALREVRAPAVLFWEFNHYVVHEGFLRRPGRRGAVRLNDPDKGRRV
                     VSAEEFDASFTGVALVLEPGPSFREGGRKPGLFGALPARLRGTGATLLTALLASLLLVV
                     VGAALPALSRTYIDLFLIGERTSVLGPLFAAMGALVALTASLTALQQANLLRGRIISST
                     LSSARFLRHLLRLPVTFFAQRSPADLVQRLQSNDTVAETLARDLAAAAVDGVVVVLYAL
                     LLWTYDPQLTVVGVGIALLNIVAMRVVIQLRATRTQKLRADNARLTTTAYTGLQLIETM
                     KATGGEDGFFRRWAGQHATTLEEQQRLGVPTAVLSVVAPALATFNSALILWIGGVRAVE
                     GHLSVGLLVAFQALMVRFTAPLTRLNGVAGRIQDFAADVTRLRDVEAFPADGLYRREGA
                     GGGEADTRRLAGRVELEGLTFGYSPLDPPLLTEFSLTVGPGRQVALVGGSGSGKSTVSR
                     LLAGLYQPWEGTIRIDGQPLTEIPRSALAASVSFVDQDIFLFEGTVRENVTLWDPSLPD
                     EAVRTALRDAGLEEVIARRPDGIHARVEQDGRNFSGGQRQRLEIARALVRRPSVLVLDE
                     VTSALDAETEQRVMAALRRRGCACVIIAHRLSTVRDSDEIVVLDGGRVVERGRHAELVA
                     RGGAYAALVEEK"
     gene            complement(3981..4787)
                     /locus_tag="G9U55_RS27480"
                     /old_locus_tag="G9U55_27700"
     CDS             complement(3981..4787)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640761.1"
                     /locus_tag="G9U55_RS27480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_27700"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_101279491.1"
                     /transl_table=11
                     /translation="MRFRQQALTKLQSPEQLDLPVRFARPQGLLVLAVTLVVMAAGGVW
                     AVTGSVATTLTAPGVLTHAQGSYVVQSTVSGQVTAVRTAEGRRVARGTPLLTVRTARGD
                     VTIRALAAGRVTALAAATGAVVTTGADLAAVERQERPDDPLLAVLYAPADSGASLRPGA
                     KVDLTVQSVPAQSYGVLRGTVKSVGRTARTRQQISAELGSTQLGEEFSRNGPPIAVEVR
                     LHPTKSTRSGYTWSTSDGPPHPLTTLTLVDGAVHLDEQRPADWLLP"
     gene            complement(5001..5216)
                     /locus_tag="G9U55_RS27485"
                     /old_locus_tag="G9U55_27705"
     CDS             complement(5001..5216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="G9U55_RS27485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_27705"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_101279490.1"
                     /sec_met_domain="strepbact (E-value: 4.3e-37, bitscore:
                     124.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYTPQVETAEIADSELDNISGGLVNGLVGTVTSSLDSVAPVSDT
                     LGTVTGVVEQTTGLNTAPVTGLVAGL"
     misc_feature    complement(5187..5202)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.07"
                     /tool="antismash"
     misc_feature    complement(5246..5266)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.98"
                     /tool="antismash"
     misc_feature    5685..5702
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.61"
                     /tool="antismash"
     gene            complement(5894..>6082)
                     /locus_tag="G9U55_RS27490"
                     /old_locus_tag="G9U55_27710"
                     /pseudo=""
     CDS             complement(5894..>6082)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018893291.1"
                     /locus_tag="G9U55_RS27490"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_27710"
                     /product="GNAT family N-acetyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RGAAALALTTFTGVPWNGPYYVRCRFRFLSERELTPGLREIRRAE
                     AAHGLDRWPRCCMCREV"
     gene            6244..6648
                     /locus_tag="G9U55_RS27495"
                     /old_locus_tag="G9U55_27715"
     CDS             6244..6648
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010636353.1"
                     /locus_tag="G9U55_RS27495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_27715"
                     /product="CU044_2847 family protein"
                     /protein_id="WP_203216179.1"
                     /transl_table=11
                     /translation="MAYLVELPVSGAGGAEEGDKGAASGPADATGVVRIEIDEVADGLV
                     QVARPGQVVARATRPLKEMLAGIRPVAENFVEGFRDMALRPDEIVVEFGLSVSAEADVV
                     ISKSSGQANFQVTLTWSTPPSGEPAADAAG"
     misc_feature    complement(8062..8076)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.68"
                     /tool="antismash"
     misc_feature    complement(9544..9556)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     misc_feature    10180..10194
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.68"
                     /tool="antismash"
ORIGIN
        1 tgccacttca cctgccagag ccccagcagc aggaagacca ccgagaccac cagcagcacc
       61 ccgatcgccg ccagcgccat cggcacgctg tgcaccagca gcagcaccag gttgaccccg
      121 gccaccgtca ccgactgcac ggcggtcggc ccgatccccg acagcacccg gcggatcgcg
      181 ctgatcccca tcgcggcact ggccagctca ccggtggagc ggcccgcgaa gaacgccgtc
      241 ggcagccgca gcagccggtc ccagacggcc ggctgcaacg ccgcctcgat ccgcccctcc
      301 agacgcagca gcgtcaacga ctggagcagc atgaacgccg ccgagaccac cccggccacc
      361 atcaccgcca cacacatctg cgcgatcagc ccggtctgcg caccgggcac gtacgcgccg
      421 agcacctgcc cggtcgccac cggcaccagc gcgcccagcg ccacggtgac caggccgctc
      481 agggcgaggt tgcgcaggtc gccgccggag ccgcgcaggc tgaagagcat cagccggcgc
      541 agcgtcagcg ggccctcggg gagcggccgg tagagcatcg tggcgcgttc ctcgaacccg
      601 gccgcctcct tggcgccgat ccggatccgc gcgcccgtcg ccgggttgag cgcctcgtac
      661 cggccgcgcc gccacagcag ggccaccggc gcgccggact tggcgcgccg ccccaccagc
      721 ggcccggcgt cggtacgcca ccactcgccg gccagccgga ccgggcgggt ccgcagccgg
      781 gccgcggtgg ccatccgctc cacccggtcg agccgcccgc cgcccgcgac cgagcgcgcc
      841 gccgaatccg gcagcgcgat gccgctcgcc cgcgccacct ggcggaagac cgcgtacacc
      901 gcgtcgtcgc ccgcctcgcc gcgcgccttc ggggagcggt cgcggcggcc gatcgagtcg
      961 agcagcgcct ggtcggcccg ctcccgtacc gcctcaccgg cgcggatacc ggccgccgcc
     1021 cggtcctcgt gggcccgctc cagccgctcc acccagccgt cgacggcggt cagcagccgg
     1081 tactgctggt ccaccaggga ctgccacagg gcgccgtcca ccagcaggtc ggccgcggcc
     1141 tcggcggcga actcggcccc cagccggaca ctgcccggcg gtacgtccac ccacagcacg
     1201 tcctcgtcgg cgggcccgga ccccgccgcg ggcccgtccg cctgcggtgc cgcgaacagc
     1261 acggcgagcc cccggccgag gccgagcccc accgcgtgct ccagcggccg ggccaccggc
     1321 tcgtacccgg ggtacgcctc gtacccctcg gccccctgcg gcgcgtacag ctcgcgcagc
     1381 ggcaggcggc gtacggcgca gcgggaggat aggcggccca ccagggtgtg gcgcgggccc
     1441 tcgacggcgc cgagcaggag cgtgccggcc tccaggcggc cgaggtagtg ccagtggccg
     1501 tcctcggcgg ccgccaccgc gaagaggtcg aggctgccct cggtgaccag ccagagcgcc
     1561 gagggcccgc cgagcggcag ggccgatccg gcggcccccg ccaccggtgc gccgagtccg
     1621 ccgagtgccg ccgtcaccgg gtcggcggcg ggggtggggt gggaagcctg ctgggtgccc
     1681 gtcatctcac ttctcctcga ccagggccgc gtacgcgccg ccccgggcga ccagttcggc
     1741 gtggcggccg cgctccacga cccggccgcc gtccagcacc acgatctcgt cgctgtcgcg
     1801 gacggtggag aggcggtgcg cgatgatcac gcaggcgcag ccgcgccgcc tgagcgccgc
     1861 catcacccgc tgctcggtct ccgcgtccag cgcgctggtc acctcgtcca gcaccagcac
     1921 gctgggacgg cggaccaggg cccgggcgat ctccagccgc tgccgctggc cgccggagaa
     1981 gttccgcccg tcctgctcga cccgggcgtg gatgccgtcc gggcggcggg cgatcacctc
     2041 ctccagtccg gcgtcgcgca gcgcggtgcg gaccgcctcg tcgggcagcg aggggtccca
     2101 gagggtgacg ttctcccgca ccgtgccctc gaagaggaag atgtcctggt cgacgaagga
     2161 gaccgaggcg gccaaggccg agcgcgggat ctcggtgagc ggctgcccgt cgatgcggat
     2221 ggtgccctcc cacggctggt acagccccgc cagcagccgg gagaccgtcg acttgccgct
     2281 gcccgacccg ccgaccagcg ccacctgccg ccccggcccg accgtcagcg agaactccgt
     2341 cagcagcggc gggtccagcg ggctgtaacc gaaggtcagc ccctccagct ccacccggcc
     2401 cgccagccgc cgggtgtccg cctcgccgcc gccggccccc tcccgccggt acagcccgtc
     2461 ggccgggaag gcctcgacgt cccgcagccg ggtcacgtcg gccgcgaagt cctggatgcg
     2521 gcccgcgacg ccgttgagcc gggtcagcgg cgccgtgaac cgcaccatca gcgcctggaa
     2581 cgccaccagc agaccgaccg acagatgccc ttcgaccgcc cgcacaccgc cgatccacag
     2641 gatcagcgcg ctgttgaagg tggcgagcgc cggggccacc accgacagca ccgccgtcgg
     2701 caccccgagc cgttgctgct cctccagcgt cgtcgcgtgc tgccccgccc accgccggaa
     2761 gaacccgtcc tcgccaccgg tcgccttcat cgtctcgatg agctggagcc cggtgtacgc
     2821 ggtggtggtc agccgcgcgt tgtcggcccg cagcttctgc gtccgggtgg cccgcagctg
     2881 gatcaccacc cgcatcgcca cgatgttcag cagcgcgatc cccaccccga ccacggtgag
     2941 ctgcgggtcg tacgtccaga gcagcagcgc gtacagcacc accaccaccc cgtcgaccgc
     3001 ggcggccgcc aggtcgcggg cgagtgtctc ggccaccgtg tcgttcgact ggagccgctg
     3061 gaccaggtcg gcgggggagc gctgggcgaa gaaggtcacc ggcagccgca gcagatggcg
     3121 caggaaccgg gcgctgctca gcgtcgagga gatgatccgc ccgcgcagca gattggcctg
     3181 ctggagcgcg gtcagcgagg cggtcagcgc caccagcgcg cccatcgccg cgaagagcgg
     3241 cccgagcacc gaggtccgct caccgatcag gaagagatcg atgtacgtcc ggctcagcgc
     3301 gggcagggcc gcgcccacca cgaccagcag caggctggcc aggagcgcgg tcagcagggt
     3361 ggcgccggtg ccgcgcagcc gggccgggag ggcgccgaac agtccgggct tccgcccgcc
     3421 ctcgcggaag gaggggcccg gttcgaggac cagggcgacg ccggtgaacg aggcgtcgaa
     3481 ctcctcggcg ctcaccaccc ggcgcccctt gtcggggtcg ttgaggcgga ccgccccgcg
     3541 ccgcccgggg cgccgcagga acccctcgtg gacgacgtag tggttgaact cccagaacag
     3601 cacggcgggg gcccgcacct cgcgcagggc ggccggttcc atctgcatgc ccttggcggt
     3661 caggccgtaa ctgcgggccg ccttcaggac gttgctggcg cgcgagccgt cgcgggagac
     3721 gccgcaggcg atccgcagct cctccagcgg gacgtgccgc ccgtggtggg cgaggaccat
     3781 ggcgaggcag gcggcgccgc actccaccgc ctccatctgg aggacggtgg gggtgcggac
     3841 cggccgcctg cggggcgtac ggcgcggggg cgcggcgcgg cggcggccgg aggagggggc
     3901 ggcgcggcgg ccccggcggc cgcccggggt gggcggggcg gtggagccgg tcccggcggc
     3961 gggggcgtcg gcgggtgcgg tcacgggagg agccaatcgg ccgggcgctg ttcgtccagg
     4021 tggacggcgc cgtcgacgag ggtgagagtg gtgagcgggt gcggcgggcc gtcggaggtc
     4081 gaccaggtgt agccgctgcg ggtgctcttc gtggggtgca ggcggacctc gacggcgatc
     4141 ggcggcccgt tccgggagaa ctcctcgccg agctgggtcg agccgagctc ggcggagatc
     4201 tgctgccggg tccgggcggt gcggccgacc gacttcacgg tgccgcgcag cacgccgtag
     4261 ctctgggcgg gcaccgactg caccgtcagg tcgaccttgg cgccgggcct gagtgaggcg
     4321 ccactgtcgg cgggggcgta gagcaccgcg aggagtgggt cgtcggggcg ttcctgccgc
     4381 tccacggcgg ccaggtcggc gccggtggtg acgacggcgc cggtggcggc ggccagcgcg
     4441 gtgacgcggc ctgcggccag agcgcggatg gtcacgtcgc cccgcgcggt gcggacggtc
     4501 agcagcgggg tgccgcgggc gacgcggcgg ccctcggcgg tgcggacggc ggtgacctgg
     4561 ccggagacgg tggactggac gacgtagctg ccctgggcgt gggtgaggac gccgggcgcg
     4621 gtgagggtgg tggcgaccga accggtgacg gcccacacgc cgccggccgc catcacgacc
     4681 agggtgacgg cgaggaccag gagtccctgc gggcgggcga accgcaccgg caggtccagc
     4741 tgttcgggcg actggagctt ggtcagggcc tgttggcgaa agcgcacgga agacttcctc
     4801 gactgccggg caccggccgg gactttgaag acatccccca ggccgtgcgg ccgggtgtcg
     4861 ccgtggtgct gggacgccgc gtgggcgtcc ggggaggaca aaggaggcgg ccggtgcccc
     4921 ggaacccgag cgggtccggg gcaccggccg agcggtccgc ctcagcgggc cgcacgcgtc
     4981 gtcaggcgac gcgcggggtc tcagagaccg gcgacgaggc cggtgaccgg ggcggtgttc
     5041 agaccggtgg tctgctccac gacgccggtg acggtgccga gggtgtcgga gaccggggcg
     5101 accgagtcga ggctggaggt gaccgtgccg acgaggccgt tcacgaggcc gccggagatg
     5161 ttgtccagct cgctgtcggc gatctcggcg gtctcgacct ggggggtgta gctcatgggg
     5221 ggagttccct tcgcatcact gacggaaata gtcaccgcgg cgcactcgtg cagaagaagg
     5281 ggaaaatcct ctggcggccc ccggacgata aggcggtgaa ccggagatcc gggggcggtg
     5341 ccgcagtgcg atggatcaaa gcacgacgct gcgcggggcg gccaatcggt gagagcggaa
     5401 tacggcgggc ggtgcccttc tcctcaccgc cgtgtgcgga atcgggcaca ggagaacggc
     5461 atcaccttca caccgtcccg ccgccgtgcg aggcggggtc accctcgcgt gtacaccacg
     5521 ccccttgctg tgaagccctg gtgcgggcca tcgacctcgg ccgttcacac gtcgtgaagg
     5581 tatgggtggc ggtgacggag ctgcggcacg gctgtgcaga tttaccgcag gagaacccgc
     5641 tccggggtgc ggcggattcg tgtgcggacg gctctgggaa ggccatgttt ccaccatgtg
     5701 gagaaacggc gtccgccgcg aggagaagaa ggagcgggag cgggggaatt gccgccggac
     5761 ggcgaattct tgcgcaccga gaaaagcgcg cgacggggca ggggcgggaa ttaccggcag
     5821 gaccgcgaaa gggcggtcgg gggagacggg cattccccgg cggcggacca gctctctccc
     5881 cggagtgctc tgctcacacc tcccggcaca tgcagcagcg gggccaccgg tccagtccgt
     5941 gcgccgcctc ggcccggcgg atctcccgca gccccggcgt cagctcacgc tccgacagga
     6001 accggaagcg gcaccgcacg tagtacgggc cgttccacgg caccccggtg aaggtggtga
     6061 gcgccagcgc cgcagcccct cgcgccgggc cctctcggcg ggcgggtgcg gcgtcgcgtg
     6121 ccttcgtcga cgttcggcca gatcgtggtg gcacaggggt gtttcgcggc gttcgagccc
     6181 cgcggtgccg gcgccgtcgg tagggtgctg ggccagcgtg gcaggtgtcg tgaaggggga
     6241 agcgtggcat atctggtcga gttgccggtg tccggggcgg gcggtgccga agagggcgac
     6301 aagggggccg cgtccggtcc ggcggacgcg accggcgtcg tcaggatcga gatcgacgag
     6361 gtcgcggacg ggctggtgca ggtcgcgcgt cccgggcagg tggtggcgcg ggcgacccgg
     6421 ccgctgaagg agatgctcgc cgggatccgg ccggtcgcgg agaacttcgt ggaggggttc
     6481 cgcgacatgg cgctgcgacc ggacgagatc gttgtcgagt tcggtctctc ggtctcggcc
     6541 gaggcggacg tggtcatctc caagtcgagc ggtcaggcca acttccaggt caccctgacc
     6601 tggtccaccc cgccgtcggg cgaaccggca gccgacgcgg cggggtgagg gtgcccgggt
     6661 caccgcccga gcgtccggtg gtgccgggcc cccggtccct ggacacggcc gtactacggg
     6721 tccgcgacgg tcgcgggcaa ggggtcggtg tggccttcct ggtctccgac accctcgccc
     6781 tgacctgcgc gcacgtcgtc caggcggcgc tggggacgac gggggacgag gcacccgacg
     6841 ccgccgcccg ggtccaggtc gaccttcccc tggtggtgcc cgccccggag cgcgacggcg
     6901 gagcgccggt gaccacggcc cgtgtcgagc actgggtacc gccgcgcgcg cccaccgagg
     6961 ggccttcggt gcccgcctcc cgtacggagt cctcgcccgg ccgagccggc ccggtcctgc
     7021 ccgccgatgt cgccgtacta cggctggagg cgccgcttcc gggggcggga ccggtgcggc
     7081 tggtcgaggc ggacgagttg tgggggcacc cgttgcgggc gtacgggttg cccgccgggc
     7141 gccccggtgg ggtctggcac gcgggcgtgc tgcgcgggcg gcaggcggac ggctgggtgc
     7201 aggccgatct cgccggtgac ggctatccgg tgtcgcgggg tttcagcggt gccccggtct
     7261 gggacgacca gctctccggt gtggtcggca tggtgacggt ggccgagtcg ggagagccgc
     7321 ccgtcagcta cctggtgccc acgagcggct tgctggcggt ccggcccgag ttgcgtgcgg
     7381 tcgcgctggc tccttcgccg ttccggggtc tgtcggcgtt cgaggaggcc gacgccgccc
     7441 tcttccacgg ccggcgggcg gagagcgagg aggtggcgcg ggcgctgtcc accgagcgcc
     7501 gtgtcaccgt cgtggggccg tctggatcgg gcaagtcgtc gctggccctg gccggagtcg
     7561 tgcccctcct gcgcgcgcgg ggcgcccagg tggtggtggt gcggccggcg cgcggcagcg
     7621 acccgttcac ctccttcgcg gccgggctgc tgcccttgct cgaacccggc ctggccgagg
     7681 acgagcgcca ggagcggacc gccgaactcg ccgacgtgct gcgccgccac ggcccggcgg
     7741 acacggtgac acgcctgctc cagctgcggc gcggcagccg actcctcctc gtggtcgacc
     7801 agttcgagga ggtcctcggc ctcgacccgg ccgccgtgga cgccttcgcc ggcctgctca
     7861 cgggcggcac gctgccggac accgtccgcg tcctgatgac gctgcgcgcc gacttcctgg
     7921 agccggtgct ggccgatccg cgactgggac cggcggccgg cgagcacctg tacgcgctcg
     7981 ccccgccgga cccggcgcgc ctgcgcgaga tcgtgaccgc ccccgtcgac gccgtacccg
     8041 cggtgtccta cgagcctcag ctcgccgacc gcatcctcgc cgacaccggc ccgggaccgg
     8101 gcgagcttcc gctcctcggc ctcaccctcg acctgttgtg gcagcggcag gagggcggcc
     8161 tgctgaccca ccgcgcctac gagcagctcg gcggtgtcgg cggcgccctg ggccgccacg
     8221 ccgaccagga gtggcgtgcg tgcgtaccgc cggaggacga ggagatcgcc aggcggctct
     8281 tcacccggct cgtccgggtc accgccggcc tgcccgcgcc cgcccggcgg acggcactcc
     8341 ggaccgaact gggcgccggg gagtggcgcg tcgcccaacg gctggcgggc accaggctgt
     8401 tggtgaccgg ccggaacgcc gagggcaccg agaccgtgga actcgcccac gaggccctga
     8461 tcgccggctg ggagaagctc tccgactggg ccaccggcga ccgcgccttc ctggagtggc
     8521 gcgccgaact gcgacaggac atgcaccgct gggaacaggc cgggcagcct ccggagctgc
     8581 tgccgacgcc cctgcaactg gcccggtccg aagagtggct ggccgcccgc ggtgacgaac
     8641 tcaccgacgc cgaacggcgc tatctggacg ccggccacac acgccgccgg acgaggctcc
     8701 gccggcgacg ggcgacgctc tcggcgatca gcttcgccgt gctgctggtc atcgtggccc
     8761 tggcggcgtt ccacgccaca cgcgaggaga gccaggaacg tgccgcggag gccgcgtccc
     8821 gtgcgctcgc gctggccgcg gcggacgaca cccgcaccga acccgccctc ggcgcgctga
     8881 aggcactggc cgcccaccgg accgcgccga cacaggaggc gcgcgacgaa ctcctgaggc
     8941 agtacttgct gtacgagggg tacgaccggg tgctctccgg cgtactcggc accgtcaggg
     9001 agttcgaggc cagcgcggac ggcgacgtgg tcctcgcggt ctcgcagctc ggccgggcca
     9061 ccctgttcac cggcgtcacc tccgggcggg tgcgcagcgc gcaggtgccc tccaccgggc
     9121 aggtcatgca cggcgtggtg gccgcggacg ggaagcgcgt cgcctatgtc caggtggacg
     9181 gcaaggcggt ctggttcgac gtggacaccg atgccgcggg cctgctcggg ccgaagcggc
     9241 gagcggtcga cgggccggac gtgcgtctcg accccgacct gacgcccgcg ctctcggcgg
     9301 acgggcgcag cctcgcctcg gtcgtggggg accggctggt gcggtgggac ctggagagcg
     9361 gcacacgcac cggtaccgcc cccgcgcccc cggagatgac gggcccgctc gcgttcgccc
     9421 cggacgggag gctcctggcg atgtcctacg gggagtcggg cacccgggtc ctgacctccg
     9481 tcgacctgtc cgagggccgg gccacgcgcc tcctgaccgg gacgcaggag atctacctct
     9541 ccggtgaccg cggcaccgcc gtcgtctgcc gcgaggaggc cggacagtcc gtcatccgcc
     9601 gccaccggac ctccgacggc accgagaccg gccgctccta ccgcgagcgg gacgaggcgt
     9661 acaccacgga cctgtgcacg ctggaggcgg tcgacgagac cgggcggcgc gtcgcgctcc
     9721 actggggtga cgaagtgcgc gtcctggatc tggacaaggg cgaggcgatc tccagagcgc
     9781 ccctgaccgg gagagccctc tcacagatcc gttcccccgg tcgtctcgcc gcatcgcgcg
     9841 gcaagctcta ccacatgggc tggaacgact cgctgatcgc ctacatggac atgactccag
     9901 ggcggcggct cctgaaagcc ggccagcacc gtctcacccc tgacggcaag cggtcgctca
     9961 tcgtccagga ggacggctcc cggaccgcgc tccacccggc cgacccgggc cggagcggac
    10021 gggtcctcgc gcgggcgaag cgtgccgagc cgtactgggt accccagaag accgatctcc
    10081 ctgtcttcga caccggcggt gccctcgtcg ccgaccgtga gggacggaac ctcgtggtcg
    10141 tccgcgacgc gtcgaccctg cggaaggtca ccaccgtgaa ggccgtccgg cccccgccca
    10201 ccgaccccga cgcccg
//
