LOCUS       NZ_CP049945            22286 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces koyangensis strain SCSIO 5802 chromosome, complete
            genome.
ACCESSION   NZ_CP049945
VERSION     NZ_CP049945.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces koyangensis
  ORGANISM  Streptomyces koyangensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces
            aurantiacus group.
REFERENCE   1  (bases 1 to 6861301)
  AUTHORS   Ding,W.
  TITLE     Genome mining and metabolic profiling illuminate the polycyclic
            tetramate macrolactams from Streptomyces koyangensis SCSIO 5802
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6861301)
  AUTHORS   Ding,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-MAR-2020) Chinese Academy of Sciences, Key Laboratory
            of Tropical Marine Bio-resources and Ecology, No.164 Xingang west
            Road, Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016803985.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:33:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,078
            CDSs (total)                      :: 5,988
            Genes (coding)                    :: 5,861
            CDSs (with protein)               :: 5,861
            Genes (RNA)                       :: 90
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 127
            CDSs (without protein)            :: 127
            Pseudo Genes (ambiguous residues) :: 0 of 127
            Pseudo Genes (frameshifted)       :: 60 of 127
            Pseudo Genes (incomplete)         :: 90 of 127
            Pseudo Genes (internal stop)      :: 7 of 127
            Pseudo Genes (multiple problems)  :: 29 of 127
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:34:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5137858
            Orig. end                         :: 5160144
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP049945.1.
            Bacteria and source DNA available from Deep sea sediment.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22286
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="12"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22286
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22286
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12286](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12286)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(200..213)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.86"
                     /tool="antismash"
     gene            760..1848
                     /locus_tag="G9U55_RS22910"
                     /old_locus_tag="G9U55_23085"
     CDS             760..1848
                     /EC_number="2.6.1.42"
                     /GO_function="GO:0004084 - branched-chain-amino-acid
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0009081 - branched-chain amino acid
                     metabolic process [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_4 (90-343). E-value: 2.3e-28.
                     Score: 91.5. Matches aSDomain:
                     nrpspksdomains_G9U55_RS22910_Aminotran_4.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657639.1"
                     /locus_tag="G9U55_RS22910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23085"
                     /product="branched-chain amino acid aminotransferase"
                     /protein_id="WP_203215703.1"
                     /transl_table=11
                     /translation="MTTPTIELKPSAHPLPEAEREAILARPGFGRHFTDHMVTVKWTEG
                     RGWHDGQLVPYGPLSLDPATNVLHYAQEIFEGLKAYRRPDGSVATFRPDANARRFQASA
                     RRLAMPELPVETFVEACDLLVAQDKAWVPPHGGEESLYLRPFMIATEVGLGVRPANEYL
                     FVVIASPAGAYFPGGVEPVSIWLSENRVRAVPGGVGDAKTGGNYAASLLAQAEAAAEGC
                     DQVAYLDAVEHKWVEELGGMNLCFVYGDRLVTPTLTGSLLAGITRDTLLSLAADLGYQA
                     EEGRVSIDQWREDSRSGALTEVFACGTAAVITPVGRVKTATDEWTQGTGEPGEVTLRLR
                     EALLALQTGRTEDQHGWMHPLG"
     aSDomain        1030..1788
                     /aSDomain="Aminotran_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G9U55_RS22910_Aminotran_4.1"
                     /evalue="2.30E-28"
                     /label="G9U55_RS22910_Aminotran_4.1"
                     /locus_tag="G9U55_RS22910"
                     /protein_end="343"
                     /protein_start="90"
                     /score="91.5"
                     /tool="antismash"
                     /translation="FRPDANARRFQASARRLAMPELPVETFVEACDLLVAQDKAWVPPH
                     GGEESLYLRPFMIATEVGLGVRPANEYLFVVIASPAGAYFPGGVEPVSIWLSENRVRAV
                     PGGVGDAKTGGNYAASLLAQAEAAAEGCDQVAYLDAVEHKWVEELGGMNLCFVYGDRLV
                     TPTLTGSLLAGITRDTLLSLAADLGYQAEEGRVSIDQWREDSRSGALTEVFACGTAAVI
                     TPVGRVKTATDEWTQGTGEPGEVTLRLREAL"
     gene            2153..2911
                     /gene="ureA"
                     /locus_tag="G9U55_RS22915"
                     /old_locus_tag="G9U55_23090"
     CDS             2153..2911
                     /EC_number="3.5.1.5"
                     /GO_function="GO:0009039 - urease activity [Evidence IEA]"
                     /GO_function="GO:0016151 - nickel cation binding [Evidence
                     IEA]"
                     /GO_process="GO:0019627 - urea metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ureA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642020.1"
                     /locus_tag="G9U55_RS22915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23090"
                     /product="urease subunit gamma"
                     /protein_id="WP_203215704.1"
                     /transl_table=11
                     /translation="MRLTPTERDRLLIFNAAQLARARQARGLRLNVPEATALISDTVCE
                     AARDGARLAEAVAAGRAVLGPGDVLPGVADVLTEIQVEAVFEDGSRLAVLADPIGGGHT
                     GDQAPGALLPGPPHAEPSPVLTLPVTNTATVPVSVTSHFHFFEANPRLRFDRAAAYGMR
                     LAVPAGSSLRFGPGETRGAGLTPIGGARVVIGFAGLVDGPLDAPGARAEALRRAAACGY
                     LGAEAPGTEPAPPGATSAPPGATSAPEADA"
     gene            2908..4710
                     /locus_tag="G9U55_RS22920"
                     /old_locus_tag="G9U55_23095"
     CDS             2908..4710
                     /EC_number="3.5.1.5"
                     /GO_function="GO:0009039 - urease activity [Evidence IEA]"
                     /GO_process="GO:0043419 - urea catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470907.1"
                     /locus_tag="G9U55_RS22920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23095"
                     /product="urease subunit alpha"
                     /protein_id="WP_225930481.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 5e-46, bitscore:
                     155.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHPADPALPDDLTPRPRAFPHLARTPHGRRTAPDEAATASDPHA
                     YAAVHGPRAGDRVRLGDTGLTVRVEADAQRAGDEFLAGFGKTARDGLHLRAAAVRETCD
                     LVISNVLVIDAVLGIRKVSIGVREGRIHAVGRAGNPDTLDGVDVVVGTGTTIVSGEGLI
                     ATAGAIDTHVHLLSPRVMEASLASGVTTIIGQEFGPVWGVGVNSPWALRHAFAAFDAWP
                     VNIGFLARGSSSHAAPLVEALAEGGACGFKVHEDMGAHTRALDTALRVAEEYDVQVALH
                     SDGLNECLSVEDTLQVLDGRTIHAFHIEGCGGGHVPDVLRMAGVPNVIGSSTNPTLPFG
                     RDAVAEHYGMIVSVHDLKPELPGDAAMARDRIRESTMGAEDVLHDLGAIGITSSDAQGM
                     GRAGETIRRTLQLAAKMKRERGPLDGDGEGDDNARVLRYLAKLTVNPARAHGLSHEVGS
                     LEPGKLADVVLWRPEYFGAKPQLVLKSGFPAYGVTGDPNAATDTSEPLVLGPQFGAHGA
                     AAAELSVAFVAGAAVGLGADALPTRRRRVPVRGTRNIGPADLLLNSRTGQVEVDARTGL
                     VTLDGDPVRSGPADSVSLNRLYFL"
     gene            4719..5798
                     /locus_tag="G9U55_RS22925"
                     /old_locus_tag="G9U55_23100"
     CDS             4719..5798
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414969.1"
                     /locus_tag="G9U55_RS22925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23100"
                     /product="agmatine/peptidylarginine deiminase"
                     /protein_id="WP_203215705.1"
                     /transl_table=11
                     /translation="MPDAPAPSLRGTVPPGFRMPPEWAPHLRTWMAWPGPNPTFATEAE
                     LASAERAWAEVARTVRRFEPVTVVAGPGRADGARALLGPGIDVVERPLDDAWMRDIGPT
                     FVTRRGDGARAALDWTFNGWGAQEWARWEHDARIGGEVAALAGVPAYRTGLVNEGGGLH
                     VDGEGTVLLTETVQLDPDRNPGLTRAEVEAEIHAGLGTSRAVWLPRGLTGDYGRFGTRG
                     HVDIVAAFARPGVVVAHTQPDPAHPDHEVCKEITGVLRAARDAAGRPLEVVEVPAPTVL
                     EVDGAWADYSYINHYLCNGGVVLCAFDDPRDAEAAALFRRLFPDRAVVPVDARPVFAAG
                     GGIHCITQQEPAPATVGQG"
     gene            complement(5820..6077)
                     /locus_tag="G9U55_RS22930"
                     /old_locus_tag="G9U55_23105"
     CDS             complement(5820..6077)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G9U55_RS22930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G9U55_23105"
                     /product="hypothetical protein"
                     /protein_id="WP_225930482.1"
                     /transl_table=11
                     /translation="MTFIDDGDVFKVCDTKADGHGVTGTLRGISHLTGKIVNLKSWDDG
                     GDSGCDGGNYDVRGNSAHDMVLCRHGGGPCKVSRVFKENE"
     gene            6671..8440
                     /gene="cimA"
                     /locus_tag="G9U55_RS22935"
                     /old_locus_tag="G9U55_23115"
     CDS             6671..8440
                     /EC_number="2.3.3.21"
                     /GO_function="GO:0043714 - (R)-citramalate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046912 - acyltransferase activity, acyl
                     groups converted into alkyl on transfer [Evidence IEA]"
                     /GO_process="GO:0009097 - isoleucine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019752 - carboxylic acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cimA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470910.1"
                     /locus_tag="G9U55_RS22935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23115"
                     /product="citramalate synthase"
                     /protein_id="WP_225930483.1"
                     /sec_met_domain="HMGL-like (E-value: 3.3e-44, bitscore:
                     149.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSQATPEEPAERAPSAATKPQVARDVRGGDGARPAPAGTPASAP
                     ATAAADAAVERPLHIFDTTLRDGAQREGINLSVADKLTIARHLDDFGVGFIEGGWPGAN
                     PRDTEFFARAREEITFRNAQLVAFGATRRAGGSAADDLQVKALLDSGAPVVTLVAKAHD
                     RHVELALRTTLDENLEMVRDTVSHLRAQGRRVFVDCEHFFDGYAANPAYAKAVVRAASE
                     AGADVVVLCDTNGGMLPAQIQAVTATVLADTGARLGIHAQDDTGCAVANTLAAVDAGAT
                     HVQCTANGYGERVGNANLFPVVAALELKYGRTVLPEGALAEMTRISHAIAEVVNLTPST
                     HQPYVGVSAFAHKAGLHASAIKVDPDLYQHIDPELVGNRIRMLVSDMAGRASIELKGKE
                     LGIDLGGDRALVGRVVERVKERELAGYSYEAADASFELLLRDELRRGADGAGDAAPSRF
                     FRVESWRAITENRPDGSHANEATVKLWAKGERLLATAEGNGPVNALDRALRVALERIYP
                     ELAKFALRDYKVRILEGRSGTDSTTRVLISTGDGDAEWSTVGVAENVIAASWHALEDAY
                     TYGLLRAGVEPAE"
     gene            8599..9963
                     /locus_tag="G9U55_RS22940"
                     /old_locus_tag="G9U55_23120"
     CDS             8599..9963
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642015.1"
                     /locus_tag="G9U55_RS22940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23120"
                     /product="hypothetical protein"
                     /protein_id="WP_203216689.1"
                     /transl_table=11
                     /translation="MLGAAGATAAPAAADQGRPAAAAPVRTAPQAPAAATVSEVAKAWR
                     DGPVFVDPDVSDQLSDAQARDLSQEIQDSDKAIFVAVLPTTFTDDVDQTMNDLRGDTGI
                     TGLYVLRIGDDLHVRADESVLSQQAVQNLESRFQDTTPADDQLTGLVGNATQNMGGRAP
                     TSWSSQESVSGSTWLGLGIAAVVVGGAAYTLTRRRKNQREQAQREALAKLRVVVDEDIT
                     AFGEELERLDFRPLEPGATDEMRGDYERGLDAYENAKSLMDRAQKPEDVREVTKALEDG
                     RFALAVLDARRSGRELPVRRPPCFFDPRHGLSVADVTWAPPGGAPREVPVCAADQARLE
                     RGEAPDIRTVESDEGGRRPYWEAGPAYGPWAGGYWGGGLLPGLLVGTMLGHMMMSPAYA
                     ADYGSAEGFGDGGAGGGYEGGDVSGSDFDPGDFGGGGFGDGGGFGGGGGDFGGGF"
     gene            complement(10001..12286)
                     /locus_tag="G9U55_RS22945"
                     /old_locus_tag="G9U55_23125"
     CDS             complement(10001..12286)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414954.1"
                     /locus_tag="G9U55_RS22945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23125"
                     /product="terpene synthase family protein"
                     /protein_id="WP_225930484.1"
                     /sec_met_domain="T1TS (E-value: 2.4e-82, bitscore: 276.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFVLPDFYVPYPARLNPHLEEARAHAREWADEMGMLEGSGVW
                     DLADLEAHDYALLCAYTHPDCDGPALSLVTDWYVWVFFFDDHFLELFKRTQDREGAKAY
                     LERLPAFMPMDLADGFPEPQNPVEAGLADLWARTVPAMSEDWRRRFALSTENLLNESMW
                     ELSNINAGRVSNPLEYIEMRRKVGGAPWSAGLIEYAAQAEVPEAVAYSRPLRVLTDAFS
                     DGVHLRNDLFSYQREVEEEGELSNGVLVLERFLECTTQEAAEAVNDLLTSRLQQFENTA
                     LTELGPLFADKGLNPAESASVLAYVKGLQDWQSGGHEWHMRSSRYMNEGAVDGEAAPPT
                     PGGSPGALAAALLAGTLGTSALDVHAFFGRPARQRARSFSHVPYRKTGASLLPDFKLPF
                     PTRLSPALEQSRVDTVAWAHRMGLLVPQPGVPGSDVWDEEALAGYDFPLCAAGLHPEAD
                     LEELNLASEWLTWGTYGDDYYPAVFGRTRNFAAAKLCTDRLRDFMPVEQPSAGPVPTSA
                     LERSLADLWVRTASAMPEKARREFRQTIEVMLDSWVWELDNQATGRIPDPIDYMEMRRA
                     TFGSDLTMSLCRLRHGNIVPEEVYRSGTIQAMEKAVSDYGALINDVFSYQKEVEFEGEI
                     HNAVLVTQNFFDCDYPTGLAYVDALMNARLEQFEHIVAHELPVLYEDFQLDGAARKMLD
                     GYVRQLENWLSAILTWHRGCKRYKEEDLSHHSPGVRRVIEAAPRGIGPNGLGASSLGTA
                     AARVFAGG"
     gene            complement(12366..12632)
                     /locus_tag="G9U55_RS22950"
                     /old_locus_tag="G9U55_23130"
     CDS             complement(12366..12632)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642012.1"
                     /locus_tag="G9U55_RS22950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23130"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_129847885.1"
                     /transl_table=11
                     /translation="MTDARSFIRSTPWFKSSYSSDAGGNCIEVAYDWRKSSYSSDAGGA
                     CVEVAAHPTTVHVRDSKVPAGPVLDVAPAAWAAFVHATAGPLV"
     gene            complement(12629..13453)
                     /locus_tag="G9U55_RS22955"
                     /old_locus_tag="G9U55_23135"
     CDS             complement(12629..13453)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414952.1"
                     /locus_tag="G9U55_RS22955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23135"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_203215707.1"
                     /transl_table=11
                     /translation="MYQRKKCSKRVTSWEVLGAQLAEFRRMAGLTQGQLAELVKVGEET
                     LSSVEQGRRRLQTDLAERLDTILETKRALTTAVLTIPPHERYPLFAQDFIDHEQTALTI
                     LSYESHVIPGLLQTPEYARTVFSNAYPPFTTHELEAAVQARVDRKQILSRETPPMMSFL
                     IEESVLHRHLGDPEAMTEQILHLRDCADLPSLSLQIMPTDTDAHAGLAGPLVLLETPEH
                     DHLAYIEGHHKGFIVEDLDEVSTYQQKYGMLRAQALSPEKTKAVLNSLIGVK"
     gene            13566..13991
                     /locus_tag="G9U55_RS22960"
                     /old_locus_tag="G9U55_23140"
     CDS             13566..13991
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414951.1"
                     /locus_tag="G9U55_RS22960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23140"
                     /product="ATP-binding protein"
                     /protein_id="WP_203215708.1"
                     /transl_table=11
                     /translation="MKTETRLPAHWERFYRRERRSVPAARDFTAAVLDEWDARVCRDDV
                     LLCVSELATNALLHGVPPGRGFRLFVLRADDGGVRVEVHDSGDGHPATRVPGDEAESGR
                     GLLLVSALADDWGVGERNPGKIVWCSFRPVGVRCPGR"
     misc_feature    complement(13595..13609)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.1"
                     /tool="antismash"
     misc_feature    13596..13610
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.69"
                     /tool="antismash"
     gene            complement(14072..14395)
                     /locus_tag="G9U55_RS22965"
                     /old_locus_tag="G9U55_23145"
     CDS             complement(14072..14395)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018893452.1"
                     /locus_tag="G9U55_RS22965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23145"
                     /product="hypothetical protein"
                     /protein_id="WP_225930485.1"
                     /transl_table=11
                     /translation="MIDGLSAGTLAELARLERTRNYLWPGAVAGTVRAWAEHVRLPRGR
                     TWPHAGYAPCHCCPDPWESRELLDEVTRALSRRGARELRRVLAGHDHLWDPAPRPYRSE
                     GPW"
     gene            complement(14552..15211)
                     /locus_tag="G9U55_RS22970"
                     /old_locus_tag="G9U55_23150"
     CDS             complement(14552..15211)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019435330.1"
                     /locus_tag="G9U55_RS22970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23150"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_225930486.1"
                     /transl_table=11
                     /translation="MTDDLRDPPDPRDLRALPLRERKKLRTRQALAETALRLFGERGFD
                     ATTLDELCDEVEVSKRTFFRNYPSKEDVALAADSDLWSAYLEYVAGLELDGPLLDTLRR
                     ALGTTLAAMDPDWDRRFLATRELAESTPAVQVHSQGYCQNTTDALVETVNARVGTGTGT
                     DTDGVRLRLTVEIFVAAWRTASLHWTTQGGPGGRDGLTRAVDEAFAEIPAALTCSA"
     misc_feature    15275..15287
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            15337..16869
                     /locus_tag="G9U55_RS22975"
                     /old_locus_tag="G9U55_23155"
     CDS             15337..16869
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018527874.1"
                     /locus_tag="G9U55_RS22975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23155"
                     /product="MFS transporter"
                     /protein_id="WP_225930487.1"
                     /transl_table=11
                     /translation="MSTVPPPPGRSRPAITLVVVLLAFVTVPMSISGAAVALPGIGEDL
                     HAAGAPLQWVMNAYNLTFASFTLVAGSAADLVGRRRTFVAGGAVFALGSLAAAAAPGIV
                     LLDLARALSGIGAAGVFASGGAILATTFDGPARTRAFAALGSAAGVGLAVGPTLSGLLV
                     GGLGWRATFGLHAVVLAVALAGAGHLAESRAERRPRLDVTGAVVFVAGLGALVLGSVQG
                     PEWGWSSPGVVSLLVAGLGLLGYFGVLQSRSAAPLLDLTLVRNRRFLALCMVPVVATFG
                     FVTLLTYLPTYLVGAGGFSPQRAGTVLLLMTAPVLLAPPLAGALANRGVSTRLLITVAL
                     AFFAGGNAWLTVLGPDTPVAVIAGPLLMTGLGAGMSFGVADGAAMSLVQPEQAGMATGF
                     LNTMRIGSEAIVIAVYGAVLVSLISTRVGSHDLAARVAAGDLGGATSGTAAAGYTDALH
                     TLLYATATVCALGTAAIALALAPPRGGPGTPVAAPSSAAPTSEDTRPPSKVA"
     gene            complement(16916..17527)
                     /locus_tag="G9U55_RS22980"
                     /old_locus_tag="G9U55_23160"
     CDS             complement(16916..17527)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470920.1"
                     /locus_tag="G9U55_RS22980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23160"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_203215710.1"
                     /transl_table=11
                     /translation="MSDDEAGQAGAEAVRAAWGRIDAWLREWAPGSYARLAPPAEPGAT
                     AAAEAALRLRFPAELRASLGCHDGAGGEGVLPVKPPLSVAGIVRYWTRWMEFTEEEREF
                     GDPEEAGEPSWHPRWIPWAESEGDAQIIDGRDGPGFGRLGMKYHDEEGSFGDDAPSLAA
                     YLTAVADVLERGGSVGGRVPYLAVSGVLWWAEEPAARPAW"
     misc_feature    complement(17582..17597)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     gene            17713..18498
                     /locus_tag="G9U55_RS22985"
                     /old_locus_tag="G9U55_23165"
     CDS             17713..18498
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414944.1"
                     /locus_tag="G9U55_RS22985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23165"
                     /product="hypothetical protein"
                     /protein_id="WP_203215711.1"
                     /transl_table=11
                     /translation="MTRKTMWRTAVAGGAAIVFTGLTAVPAGAAEGGVSFTRVKVNNGQ
                     PIVLGVKEIVEIPASVRMTTRHKFDGGPTVYPYRNTPAGVGDALWSSIHTSDPTVVDKA
                     KGIYDFDLSIHIDPRHKDVTNGDTGTWRTRAEMWLADGTYDMDDENLPLQVKRATRLTV
                     NATPEPVTKGRTLTVKGTVTRANWDTHTYQGYAGRTVSLQFKPTGAASYKTVKKVTSDS
                     KGGLKTTVKATESGTWRWTYYGNSTSGARSSSGDHVALR"
     gene            complement(18513..20183)
                     /gene="murJ"
                     /locus_tag="G9U55_RS22990"
                     /old_locus_tag="G9U55_23170"
     CDS             complement(18513..20183)
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0034204 - lipid translocation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="murJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414943.1"
                     /locus_tag="G9U55_RS22990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23170"
                     /product="murein biosynthesis integral membrane protein
                     MurJ"
                     /protein_id="WP_203215712.1"
                     /transl_table=11
                     /translation="MTQGADSAVRARTAEGRAKGAGGGLVRSSVLMAVGTVVSRATGLI
                     RQVLQAAALGTGLLASTYNTANTVPTSLYTLLIGGALNAVLVPQLVRARATEPDGGRAY
                     EQRLVTLVVCVLGVGTALAVWAAPEIVGLYMRDTPGSHEAFELTVTFARFLLPQIFFYG
                     LFGIYGQLLNAREKFGAMMWTPVLNNVVLVAMFAAYLGLMAAPGRVEDITADQVRLLGI
                     GTTAGVAIQALALVPFARAAGFRFRPRFDWRGNGLGRSVHAAKWTLLFVLANQVALTVV
                     TNFANAADQELPQAGAGYTAYTYAQTIWLLPQSIVTVSLVTALLPHMSRAVAEGRLGDL
                     RADLTRGLRISGVVIVPTAFLFLALGPQIAALLFAHGAADAASVRPLGHMLQAFGPGLI
                     AFSAQYLLLRGFYAFEDTRTPFFMAAWIAGVDIALASACHVLLPARWAVVGMAGAYTLS
                     YLAGLALTARLLRRRLGGRIGTGGLGRAYGKLLCAAVPAAGLGWAAARAVSGPGGPGTA
                     GTWSTAVALASGVLSTAVAYLLLARLLKVEEVRRLPGLR"
     gene            complement(20264..20941)
                     /locus_tag="G9U55_RS22995"
                     /old_locus_tag="G9U55_23175"
     CDS             complement(20264..20941)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414941.1"
                     /locus_tag="G9U55_RS22995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23175"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_203215713.1"
                     /transl_table=11
                     /translation="MSDHGTTGPAGDEERAGAVRDAWARIDAWMRAHAPDSYEVLAPPA
                     DPAAVEAAQAEMGVRFPADLLASLACHDGLRHWDNCLPLRPPEPVARIVGHWQMCVEID
                     EANRADEDEPEPEGEEPWWHPQWIPWAQSDGDAQIIDMRPGPAQGRLGMAYHDDCGVFT
                     DGWPSLAAYLTEVADVLEKGGAVGGTWAPFLTTEGELWWSLKGETQLNGEPLVPAPAPL
                     AGS"
     gene            complement(21093..21575)
                     /locus_tag="G9U55_RS23000"
                     /old_locus_tag="G9U55_23180"
     CDS             complement(21093..21575)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (4-154). E-value: 4e-20.
                     Score: 64.6. Matches aSDomain:
                     nrpspksdomains_G9U55_RS23000_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414939.1"
                     /locus_tag="G9U55_RS23000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23180"
                     /product="SRPBCC family protein"
                     /protein_id="WP_026048269.1"
                     /transl_table=11
                     /translation="MRSTAEVSVAAVIEAEPKAVYERVADVASMGRWSPECVRTAAGVG
                     PAPVGAEFKGTNKGPSGRSWSTRCRVMVARSGERFTFRVRFWGMPVATWDYRFRPVGDG
                     TATEVTETAVDQRNRLLWFLGSAVSGVWDRSAHNAETMRETLERLRETLEAERRAG"
     aSDomain        complement(21114..21563)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G9U55_RS23000_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="4.00E-20"
                     /label="G9U55_RS23000_Polyketide_cyc2.1"
                     /locus_tag="G9U55_RS23000"
                     /protein_end="154"
                     /protein_start="4"
                     /score="64.6"
                     /tool="antismash"
                     /translation="AEVSVAAVIEAEPKAVYERVADVASMGRWSPECVRTAAGVGPAPV
                     GAEFKGTNKGPSGRSWSTRCRVMVARSGERFTFRVRFWGMPVATWDYRFRPVGDGTATE
                     VTETAVDQRNRLLWFLGSAVSGVWDRSAHNAETMRETLERLRETLE"
     misc_feature    21591..21607
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.96"
                     /tool="antismash"
     gene            21703..22068
                     /locus_tag="G9U55_RS23005"
                     /old_locus_tag="G9U55_23185"
     CDS             21703..22068
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010641993.1"
                     /locus_tag="G9U55_RS23005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_23185"
                     /product="signal peptidase I"
                     /protein_id="WP_117349010.1"
                     /transl_table=11
                     /translation="MSENVYVGNAPEEAALDAGWIMGHFKAPDDPRHNEAVEIKWGVHE
                     AGERRAAWVRGEERQALLVLISGRFRMEFPGQDVVLSEQGQYVIWGKGVDHSWEAEEPS
                     VVMTVRWPSVPGYRVSP"
ORIGIN
        1 gtacccggac gtcaccaccg actacctgca cgtcgacgcc gcgacgatct tcttcgtcac
       61 ccagccggag cggttcgacg tcatcgtcac cgacaacctc ttcggcgaca tcatcaccga
      121 cctcgccgcg gccgtcaccg gcggcatcgg cctggccgcc tccggcaaca tcaacccgac
      181 gggcgccttc ccgtcgatgt tcgagccggt ccacggctcc gcccccgaca tcgccgggca
      241 gggcaaggcc gacccgaccg ccaccatcct ctccgtcgcc ctcctgctgc ggcacctcgg
      301 ctacgaggcc caggccgccc gcatcgagga ggccgtctcc gccgacctcg cggagcgcga
      361 cggaaccgcg cgcaccaccg acgccatcgg cgacgcgctc gccggacgag tagccggctg
      421 acccggcgcg cgacacccga agccgccggg tcccacggga caacccggcg gcttcctcgt
      481 gggcggcccc gggtgcgaga acccagggcc cgcgctcacc ccgcaccccc tgccgctccg
      541 ccgcgtgaca cgttctgcgg ggcggtggac tccgcggcgt tccctcaccg ccccctccgg
      601 cgcgataatc gaacgtgggg ccgcggaaaa tgaggcgata cccggacgtc cgtgtggtgc
      661 acagctgacc ggagtgcgag acagcacccc ggccacgcac cactcagggg tacgggcgtg
      721 agcgcggtcc gtcaccacca cacgtgaagg acaccactca tgacgacgcc gacgatcgaa
      781 ctgaagccct ccgcgcaccc gctcccggag gccgagcgcg aggcgatcct cgcccgcccc
      841 ggcttcggcc ggcacttcac cgaccacatg gtcaccgtga agtggaccga gggccgcggc
      901 tggcacgacg gccagctcgt tccctacggg ccgctctccc tcgaccccgc caccaacgtc
      961 ctccactacg cccaggagat cttcgagggg ctcaaggcgt accgccgccc cgacggctcc
     1021 gtggccacct tccgccccga cgccaacgcc cgccgcttcc aggcctccgc gcgccgcctc
     1081 gccatgcccg agctgcccgt cgagaccttc gtcgaggcgt gcgacctgct ggtggcccag
     1141 gacaaggcgt gggtcccgcc gcacggcggc gaggaatccc tctacctgcg gcccttcatg
     1201 atcgccacgg aggtcgggct cggcgtcagg cctgccaacg agtacctctt cgtggtcatc
     1261 gcctccccgg ccggcgcgta cttccccggc ggcgtcgagc ccgtctcgat ctggctctcc
     1321 gagaaccggg tccgcgccgt ccccggcggc gtcggcgacg ccaagaccgg cggcaactac
     1381 gccgcctccc tcctcgccca ggccgaggcc gccgccgagg gctgcgacca ggtcgcctac
     1441 ctcgacgcgg tcgagcacaa gtgggtcgag gaactgggcg gcatgaacct ctgcttcgtc
     1501 tacggcgacc gcctcgtcac ccccaccctc accggctccc tcctcgccgg catcacccgc
     1561 gacaccctcc tctccctcgc cgccgacctc ggctaccagg ctgaggaagg ccgcgtctcc
     1621 atcgaccagt ggcgcgagga cagccgcagc ggcgccctga ccgaggtctt cgcctgcggc
     1681 acggccgccg tcatcacccc cgtcggccgc gtcaagaccg ccaccgacga gtggacccag
     1741 ggcaccggcg aacccggcga ggtcaccctc cgtctccgcg aggccctcct cgccctccag
     1801 acgggccgca cggaggacca gcacggctgg atgcacccgc tgggctgagc ctcgggggtc
     1861 cggtgccggg cgcgtgggag cgcgtggggc cgggctgacc ggacgaccgg gacggcccgt
     1921 cgtctccgca gcggatgcgg gggtggcggg ccgtttcggg tcggggggac gccgacgccg
     1981 gtgccgccgc ggcgtcgcgg gggcacccct tacctctcgc ggcgggcccg ccgccgtgca
     2041 agtgcaacgg ggcggcgctg gttcctgccg gagagcccgc ccgccatcca ttggaaaacc
     2101 taaatgcttt agatagggtg gcgctccacc gcccccaacc cccaggaccc ccatgcgcct
     2161 gacccccacc gaacgcgacc gtctcctcat cttcaacgcc gcccagctcg cccgagcccg
     2221 gcaggcgcgc gggctgcggc tgaacgttcc ggaggcgacc gccctcatct cggacaccgt
     2281 ctgtgaggcg gcgcgggacg gggcgcggct cgcggaggcg gtggcggcgg ggcgggccgt
     2341 gctcgggccg ggcgacgtgc tgccgggcgt cgccgacgtg ctgaccgaga tccaggtcga
     2401 ggcggtcttc gaggacgggt cccggctcgc cgtgctggcc gatcccatcg gcggcggcca
     2461 caccggcgac caggcgcccg gcgccctgct cccgggcccg ccccacgccg agccgagccc
     2521 cgtactgacc ctgccggtca ccaacaccgc cacggttccg gtcagcgtca cctcgcactt
     2581 ccacttcttc gaggccaacc cgcgcctgcg cttcgaccgg gccgccgcct acggcatgcg
     2641 cctcgccgtc ccggccggct cctcgctccg cttcggcccg ggcgagaccc gcggggcggg
     2701 gctgacgccg atcggcgggg cgcgcgtcgt catcggcttc gccgggctgg tcgacggccc
     2761 gctggacgcc cccggcgccc gcgccgaggc cctgcgccgc gccgccgcct gcggctacct
     2821 cggcgccgaa gcgcctggta cggagcccgc cccgcccggc gccacctctg ccccgcccgg
     2881 cgccacctcc gccccggagg ccgacgcatg agccaccccg ccgatccggc cctccctgac
     2941 gacctcaccc cgcgcccccg cgctttcccg catctggccc gtaccccgca cggccgccgt
     3001 accgcgcccg acgaggcggc caccgcctcc gatccgcacg cctacgccgc cgtccacggc
     3061 ccccgcgcgg gggacagggt gcggctcggt gacacggggc tgacggtgcg ggtcgaggcc
     3121 gatgcgcagc gggccgggga cgagttcctg gccgggttcg ggaagacggc gcgcgacggg
     3181 ctccatctgc gggccgccgc cgtgcgcgag acctgcgacc tggtgatcag caacgtcctg
     3241 gtgatcgacg cggtgctcgg catccggaaa gtctcgatcg gtgtccggga aggccgtatc
     3301 cacgccgtcg ggcgcgcggg gaacccggat acgctcgacg gggtcgacgt ggtggttggc
     3361 accggcacca cgatcgtgtc gggggagggg ctgatcgcga ccgccggggc gatcgacacc
     3421 catgtgcacc tgctctcacc ccgcgtcatg gaagcctccc tcgcctccgg cgtgaccacg
     3481 atcatcggcc aggagttcgg cccggtctgg ggcgtcggcg tcaactcgcc gtgggccctg
     3541 cgccacgcct tcgccgcctt cgacgcctgg cccgtcaaca tcggcttcct cgcccgcggt
     3601 tcctcctcac acgccgcgcc gctggtcgag gcgctggcgg agggcggggc gtgcgggttc
     3661 aaggtgcacg aggacatggg ggcgcacacc cgggcgctgg acaccgcgct gcgcgtcgcc
     3721 gaggagtacg acgtgcaggt ggccctgcac agcgacggcc tcaacgaatg cctctccgtc
     3781 gaggacaccc tccaggtgct cgacgggcgc accatccacg ccttccacat cgaggggtgc
     3841 ggcggcggcc acgtacccga cgtgctgcgt atggcgggcg tgccgaacgt catcggctcc
     3901 tccaccaacc ccacgctgcc cttcggccgg gacgccgtcg ccgagcacta cggcatgatc
     3961 gtctcggtcc acgacctcaa gcccgagctg cccggcgacg ccgcgatggc ccgcgaccgc
     4021 atccgcgagt cgacgatggg cgccgaggac gtcctgcacg acctgggcgc catcggcatc
     4081 acctcctccg acgcgcaggg gatggggcgg gccggcgaga cgatccgccg caccctccag
     4141 ctcgccgcca agatgaagcg tgaacgcggt ccgctggacg gtgacggtga gggcgacgac
     4201 aacgcccgcg tcctgcgcta cctcgccaaa ctcaccgtca acccggcccg cgcgcacggc
     4261 ctctcccacg aggtcggctc gctggagccc ggcaaactcg ccgacgtcgt gctgtggcgc
     4321 cccgagtact tcggcgccaa gccccagctg gtcctgaagt ccgggttccc cgcctacggc
     4381 gtcaccggcg accccaacgc cgccaccgac accagcgaac cgctcgtcct cggcccccag
     4441 ttcggcgcgc acggggcggc cgccgccgag ctctccgtcg ccttcgtcgc gggcgccgcc
     4501 gtgggcctcg gcgccgacgc cctgccgacc cgcaggcgcc gtgtccccgt acgcggcacc
     4561 cggaacatcg gccccgccga cctcctcctc aactcccgta ccggccaggt cgaggtggac
     4621 gcccgcaccg gcctggtcac cctcgacggc gacccggtcc gctccggccc cgccgactcc
     4681 gtcagcctca accgcctcta cttcctctga ggaccgccat gcccgacgcc cccgccccgt
     4741 ccctgcgcgg caccgtcccg ccgggcttcc gcatgccgcc cgagtgggcc ccgcacctgc
     4801 gcacctggat ggcctggccc ggccccaacc cgaccttcgc caccgaggcc gaactcgcct
     4861 cggccgaacg cgcctgggcg gaggtggccc gcaccgtacg ccgcttcgaa ccggtcaccg
     4921 tcgtcgccgg gcccggccgc gccgacggcg cccgcgcgct cctcgggccc ggcatcgacg
     4981 tggtcgaacg cccgctggac gacgcctgga tgagggacat cggcccgacc ttcgtcactc
     5041 gcaggggcga cggtgcgcgc gcggcgctcg actggacgtt caacggctgg ggcgcgcagg
     5101 agtgggcgcg ctgggagcac gacgcgcgga tcggcggcga ggtcgcggcg ctggccggag
     5161 tgccggcgta ccgcacgggc ctggtcaacg agggcggcgg gctgcacgtc gacggggagg
     5221 gcaccgtgct gctcaccgag accgtccagc tcgacccgga ccgcaacccc ggcctgaccc
     5281 gtgccgaggt cgaggccgag atccacgcgg ggctcggcac cagcagggcg gtgtggctgc
     5341 cgcgcgggct gaccggtgac tacgggcggt tcgggacgcg cggccacgtc gacatcgtcg
     5401 cggcgttcgc ccggcccggc gtggtcgtgg cgcacaccca gcccgacccg gcccaccccg
     5461 accacgaggt ctgcaaggag atcaccggcg tgctgcgcgc cgcccgggac gcggcgggcc
     5521 gcccgctgga ggtggtcgag gtgcccgcgc ccaccgtgct ggaggtggac ggggcgtggg
     5581 ccgactactc gtacatcaac cactacctgt gcaacggcgg ggtcgtcctc tgcgccttcg
     5641 acgacccgcg cgacgccgag gccgccgcgc tcttccgccg cctcttcccg gaccgcgccg
     5701 tcgtccccgt cgacgcccgc ccggtcttcg cggccggcgg cggcatccac tgcatcaccc
     5761 agcaggaacc ggcgccggcc acggtcggcc agggctgagc ccgtcgcgcg gcgtggtgac
     5821 tactcgttct ccttgaagac ccgggagacc ttgcaggggc caccgccgtg ccggcacagc
     5881 accatgtcgt gggccgaatt gcccctgacg tcgtagttcc ctccgtcgca gccgctgtct
     5941 ccgccgtcgt cccagctctt caggttgacg atcttgccgg tgaggtgact gatcccccgc
     6001 agcgttccgg tgacgccgtg gccgtcagcc ttggtgtcgc agaccttgaa gacgtctccg
     6061 tcgtcgatga acgtcatgtc gccgcggtcg tacggaagct cgacaccggc gttggctgcc
     6121 gccgccggag ctgccgtgaa accgatcagc acggcagcgg ccgcagctgt ctgcggcccc
     6181 cgtgtacggc ggtccctctg cccaggcgcc tccgggacag gagcgcaggc gacgggaatg
     6241 tccggtaccg gtggctcggg cgtccgggac cgatcgcggc gcggcggcgc cgacgggccc
     6301 gtcggcgccg agacgggctc gccccccgcc gaggccggtc ccgcgtcccc cgcctccgcg
     6361 cccgcgaaaa cggacgcccc gctcgcatcc tgagacacct cgtggcacgg cggagtctct
     6421 gtgggagact gcccccgtgc ccacgttcgc catgattatc ggcagcaggc gcgccggtcc
     6481 gcagtgaccg ccccgcacca ccacgtgcga cgcggccacc gtgccccaga cccgcgcgca
     6541 gacctctcgc acccgcgagg ggtcttttcg tttgtcggcc ccgaccgggc cgcggcgagg
     6601 cgcacgagag gatgggggca agtggagcca agcattccgg agccactcac ccgacaggag
     6661 tcaccaccgc atgaccagcc aggccacccc cgaggaaccc gctgagcgcg ccccgtccgc
     6721 cgcgacgaaa ccgcaggtcg cgcgcgacgt gcggggcggc gacggggcgc gccccgcacc
     6781 cgccggaacc cccgcctccg ccccggccac cgccgccgcg gacgccgccg tcgagcgccc
     6841 cctgcacatc ttcgacacca cgctccgcga cggcgcgcag cgggagggca tcaacctcag
     6901 cgtcgccgac aagctgacca tcgcccggca cctggacgac ttcggggtgg gcttcatcga
     6961 gggcggctgg cccggcgcca acccgcgcga caccgagttc ttcgcccgcg cccgcgagga
     7021 gatcaccttc cgcaacgcgc aactcgtcgc cttcggcgcc acccgccgcg cgggcggcag
     7081 cgccgccgac gacctccagg tcaaggcgct cctcgactcc ggcgccccgg tcgtcaccct
     7141 ggtcgccaag gcccacgacc gccacgtcga gctggccttg cgcaccaccc tggacgagaa
     7201 cctggagatg gtccgcgaca ccgtctccca cctgcgcgcc cagggccgcc gggtcttcgt
     7261 cgactgtgag cacttcttcg acgggtacgc cgccaacccg gcctacgcca aggccgtcgt
     7321 ccgcgccgcc agcgaggccg gcgccgacgt cgtcgtcctc tgcgacacca acggcggcat
     7381 gctgcccgcg cagatccagg ccgtcaccgc caccgtcctc gccgacaccg gcgcccgcct
     7441 cggcatccac gcccaggacg acaccggctg cgccgtcgcc aacaccctcg ccgccgtcga
     7501 cgcgggcgcc acccacgtcc agtgcaccgc caacggctac ggcgagcgcg tcggcaacgc
     7561 caacctcttc ccggtcgtcg ccgccctgga gctgaagtac ggccggaccg tgctgcccga
     7621 gggggcgctc gccgagatga cccgcatctc gcacgccatc gccgaggtcg tcaacctcac
     7681 cccctccacc caccagccct acgtcggcgt ctccgccttc gcccacaagg ccggactgca
     7741 cgcctccgcg atcaaggtcg accccgacct gtaccagcac atcgacccgg agctggtcgg
     7801 caaccgcatc cggatgctcg tctccgacat ggccggccgt gcctccatcg agctgaaggg
     7861 caaggagctc ggcatcgacc tcggcggcga ccgcgccctg gtcggccgcg tcgtggagcg
     7921 ggtcaaggaa cgcgagctgg ccgggtactc ctacgaggcc gccgacgcct cgttcgagct
     7981 gctgctccgt gacgagctgc ggcgcggcgc cgacggtgcg ggcgacgcgg ccccgtcccg
     8041 cttcttccgc gtcgagtcgt ggcgggcgat caccgagaac cgccccgacg gcagccacgc
     8101 caacgaggcc accgtgaagc tctgggccaa gggcgaacgc ctgctcgcca ccgccgaggg
     8161 caacggcccc gtcaacgccc tggaccgcgc cctgcgcgtc gccctggagc ggatctaccc
     8221 ggagctggcc aagttcgccc tgcgggacta caaggtccgc atcctggaag gccgctccgg
     8281 caccgactcc accacccgcg tcctgatctc caccggcgac ggcgacgcgg agtggtcgac
     8341 ggtcggcgtc gccgagaacg tcatcgccgc ctcctggcac gccctggagg acgcgtacac
     8401 ctacggcctg ctccgcgccg gggtcgagcc cgccgagtag gcccgacgcg cgtacgcccg
     8461 gggcggcggg gccccgtacc cgccccgccg ccgttcgggg cggttcgccg cgacccgggt
     8521 tagcgtggag gtatgaggcg agccgtagtc cgccagtcca tacgccgggg cgctctcatc
     8581 gcgtccgggc ctcttctcgt gctgggcgcc gccggagcga cggccgcgcc cgccgccgcc
     8641 gaccagggca ggcccgccgc cgcggcaccg gtgcggacgg ctccgcaggc ccccgccgcc
     8701 gcgaccgtct ccgaggtggc caaggcgtgg cgcgacggcc ccgtcttcgt ggacccggat
     8761 gtctcggacc agctctccga cgcccaggcg cgcgacctct cccaggagat ccaggacagc
     8821 gacaaggcga tcttcgtcgc ggtcctcccc accacgttca ccgacgacgt ggaccagacc
     8881 atgaacgatc tccggggcga caccggcatc accggcctgt acgtgctgcg catcggcgac
     8941 gacctgcacg ttcgcgccga cgaatcggtc ctgtcgcagc aggccgtgca gaacctcgaa
     9001 tcccgcttcc aggacaccac cccggccgac gaccagctca ccggcctggt gggcaacgcc
     9061 acccagaaca tgggcggccg ggcccccacc tcgtggtcct cccaggagag cgtctccggc
     9121 tcgacctggc tcggcctcgg catcgccgcc gtggtcgtgg gcggcgccgc gtacacgctg
     9181 acccggcggc ggaagaacca gcgcgagcag gcccagcggg aggcgctggc caagctgcgg
     9241 gtcgtggtcg acgaggacat caccgcgttc ggcgaggagc tggagaggct cgacttccgg
     9301 cccctggaac ccggcgccac cgacgagatg cgcggcgact acgagcgcgg tctcgacgcc
     9361 tacgagaacg ccaagtccct catggaccgg gcccagaagc ccgaggacgt gcgcgaggtg
     9421 accaaggcgc tggaggacgg ccggttcgcg ctcgccgtgc tcgacgcccg ccgcagcggt
     9481 cgcgaactcc ccgtacgccg cccgccgtgc ttcttcgacc cgcgccacgg tctctcggtc
     9541 gccgacgtca cctgggcccc gcccggcggc gcgccccgcg aggtgcccgt ctgcgccgcc
     9601 gaccaggcaa ggctggagcg gggcgaggcc cccgacatcc gcaccgtcga gtccgacgag
     9661 ggcggccggc gcccgtactg ggaggccggc ccggcgtacg gaccgtgggc cggcgggtac
     9721 tggggcggcg gcctgctccc cgggctcctc gtcggcacca tgctcggcca catgatgatg
     9781 agccccgcct acgccgccga ctacggctcg gccgaagggt tcggcgacgg cggcgcgggc
     9841 ggcggctacg agggcggcga cgtctccggc tccgacttcg accccggtga cttcgggggc
     9901 ggcggcttcg gcgacggcgg cggtttcggc ggcggaggcg gcgacttcgg cggaggcttc
     9961 tgaagccgcc gaagccgccg ccctccccgg cccgctcccg tcaccccccg gcgaacaccc
    10021 gggcggcggc cgtgcccagc gaggacgcgc cgagcccgtt cggcccgatc ccgcgcggcg
    10081 cggcctcgat cacccgccgc acgccggggg agtggtggct caggtcctcc tccttgtacc
    10141 gcttgcagcc ccggtgccag gtcaggatgg ccgacagcca gttctccagc tgccgcacgt
    10201 acccgtcgag catcttcctg gcggccccgt ccagctggaa atcctcgtac agcacgggga
    10261 gttcgtgggc cacgatgtgt tcgaactgtt ccagccgcgc gttcatcagc gcgtccacgt
    10321 acgccagccc ggtcgggtag tcgcagtcga agaagttctg tgtgacgagg acggcgttgt
    10381 ggatctcgcc ctcgaactcg acctccttct ggtacgagaa gacgtcgttg atcagcgcgc
    10441 cgtagtcgga gacggccttc tccatcgcct ggatggtgcc cgagcggtac acctcctcgg
    10501 ggacgatgtt gccgtggcgc aggcggcaca ggctcatcgt caggtcggag ccgaaggtgg
    10561 cgcggcgcat ctccatgtag tcgatcgggt cggggatgcg gccggtggcc tggttgtcca
    10621 gctcccagac ccagctgtcc agcatcacct cgatggtctg ccggaactcg cggcgcgcct
    10681 tctccggcat cgcggaggcg gtccgcaccc acaggtcggc gagtgaccgt tccagggcgc
    10741 tggtcggcac cggccccgcc gagggctgct cgaccggcat gaagtcccgc agccggtcgg
    10801 tgcagagctt ggccgcggcg aagttccggg tgcggccgaa gaccgccggg tagtagtcgt
    10861 ccccgtaggt gccccaggtc agccactccg aggcgaggtt cagttcctcc aggtccgcct
    10921 ccgggtggag cccggccgcg cagagcggga agtcgtagcc ggccagcgcc tcctcgtccc
    10981 acacgtccga cccgggcacc cccggctgcg gcacgagcag ccccatccgg tgcgcccacg
    11041 cgaccgtgtc cacccgcgac tgctccagcg ccggggagag ccgcgtcggg aacggaagct
    11101 tgaagtccgg cagcagggag gccccggtct tccggtacgg cacgtgcgag aagctgcgcg
    11161 cccgctgccg cgccggacgc ccgaagaagg cgtgcacgtc cagcgccgac gtgcccagcg
    11221 tcccggccag caacgccgcc gccagcgccc ccggcgaccc gcccggcgtc ggcggcgccg
    11281 cctccccgtc gacggcgccc tcgttcatgt accggctgga gcgcatgtgc cactcgtggc
    11341 cgcccgactg ccagtcctgg agccccttca cgtacgccag caccgaggcg gactcggccg
    11401 gattcagccc cttgtcggcg aagagcggcc ccagttcggt cagcgcggtg ttctcgaact
    11461 gctggaggcg tgaggtcagc aggtcgttga cggcctcggc cgcctcctgc gtggtgcact
    11521 ccaggaaccg ttccagcacg aggacgccgt tgctcagctc gccctcctcc tcgacctccc
    11581 gctggtagga gaagaggtcg ttgcgcaggt ggacgccgtc cgagaaggcg tcggtgagca
    11641 cgcgcagggg ccgcgagtac gccaccgcct ccggcacctc ggcctgcgcg gcgtactcga
    11701 tcagccccgc cgaccagggc gcgccgccga ccttgcggcg catctcgatg tactccagcg
    11761 ggttggagac gcggcccgcg ttgatgttgg agagttccca catcgactcg ttgagcaggt
    11821 tctccgtgga gagggcgaag cggcggcgcc agtcctccga catggccgga accgtccgcg
    11881 cccagaggtc ggcgagcccc gcctccaccg gattctgcgg ctccgggaaa ccgtcggcca
    11941 gatccatcgg catgaacgcc ggcagccgtt ccaggtacgc cttcgcgccc tcacggtcct
    12001 gcgtccgctt gaacagctcc aggaagtggt cgtcgaagaa gaagacccac acgtaccagt
    12061 cggtcaccag cgacagcgcc ggaccgtcgc agtccggatg cgtgtacgcg cagagcaacg
    12121 cgtagtcgtg ggcctccagg tcggccaggt cccagacgcc cgacccctcc agcatcccca
    12181 tctcgtccgc ccactcccgg gcgtgggcgc gcgcctcttc gagatgaggg ttgagccgcg
    12241 ccgggtacgg cacgtagaaa tcgggcagga caaagggctg tgtcacagtc gggccttcca
    12301 cacggtgatt ccggcggccc gatcactacc cgcccgcccg ccccgtcagc cggacggcgg
    12361 tgttgtcata cgagtggacc ggcggtcgcg tgtacgaacg ccgcccaggc ggcgggggcc
    12421 acgtcgagga cggggcccgc cgggaccttg gagtcgcgga cgtggacggt ggtggggtgg
    12481 gcggcgactt ctacgcaggc gccgcccgcg tcgctgctgt agctggactt acgccagtcg
    12541 taggcgacct cgatgcagtt gcctccggcg tcactgctgt agctcgactt gaaccatggc
    12601 gtggacctga tgaaggaacg tgcgtcggtc atttcactcc gatcaacgag ttcaggacag
    12661 ctttggtctt ttccggcgag agggcctgcg ctctcagcat cccgtatttc tgctggtacg
    12721 tactgacttc gtccaagtct tccacgatga agcccttgtg gtgcccctcg atgtaggcga
    12781 ggtggtcgtg ttccggcgtt tccagcagga caagaggccc ggccagaccc gcgtgtgcgt
    12841 ccgtgtcggt cggcatgatc tgcaagctca gggaaggtag gtcggcacag tcccgaaggt
    12901 gcaggatctg ctccgtcatc gcctcggggt cgcccaagtg ccggtgcagt actgactctt
    12961 cgatgaggaa gctcatcatt ggaggagttt cgcgagacag aatctgtttc ctgtcgacgc
    13021 gtgcctgtac ggctgcctcc agctcgtgcg tggtgaatgg cggatatgcg ttgctgaaaa
    13081 ccgtccgtgc gtattccggc gtttgtagca gtccgggaat gacgtgactc tcgtacgaga
    13141 ggatggtgag ggccgtttgt tcgtggtcga tgaagtcttg ggcgaacaat gggtaccgct
    13201 cgtggggcgg aatcgtcaac accgctgtgg tgagtgctct cttcgtctcc aggatcgtgt
    13261 ccaggcgctc agccaggtcc gtctggagcc gtcgcctccc ctgttcgact gacgagaggg
    13321 tttcttcgcc aaccttcacc agttccgcca gttgcccctg agtcagcccg gccattcgtc
    13381 gaaactccgc cagttgcgct cccagcacct cccacgacgt gactcttttg ctgcacttct
    13441 tcctctgata catgcctggt tcctgtcccg aagtacccca ctgcgcaccc gacacgaccc
    13501 gtacaacgga tttgtacggg tcgacgccct gcacaaggct agtgacgttg ggtgaccgta
    13561 ggagggtgaa aaccgaaacc cgactccccg cgcactggga gcgcttctac cgtcgcgagc
    13621 gccgatccgt ccccgcagcc agggacttca ccgctgccgt gctggacgag tgggacgccc
    13681 gcgtgtgccg cgacgacgtc ttgctctgcg tgagcgaact cgccaccaac gccctgctcc
    13741 acggcgtccc gcccggccgg ggcttccggc tcttcgtgct ccgggccgac gacggcggcg
    13801 tacgcgtcga ggtccacgac agtggcgacg ggcaccccgc gacccgtgtc cccggcgacg
    13861 aggccgagtc aggccggggc ctgctcctgg tctccgccct cgccgacgac tggggggtgg
    13921 gggagcgcaa cccgggcaag atcgtctggt gctccttccg cccggtgggc gtccgttgcc
    13981 cgggaaggtg actccccgcc cgctgccgtc ctgagtcgcg acggccggaa ccggggcgag
    14041 gcccgcgagg gtccgccggg ccgcgtcggc ctcaccacgg gccctcgctc cggtacggcc
    14101 ggggcgccgg gtcccagagg tggtcgtgcc cggccagtac gcgccgcagc tcgcgcgccc
    14161 cgcgccggga cagggcgcgg gtgacctcgt ccagcagctc ccgggattcc caagggtcgg
    14221 ggcagcagtg acagggggcg tacccggcgt gcggccacgt ccgtccccgc ggcagccgca
    14281 cgtgctcggc ccaggcgcgt acggttccgg ccacggcgcc cggccacaga tagttccgcg
    14341 tgcgctccag tcgggccagc tcggcgagtg tcccggccga cagcccgtcg atcacgggcg
    14401 acttctcgta gggcctgcgg ggccggggga gtccggcccg tacccttccc ggcggcttac
    14461 gcggcacggg cctttcggtg gtaggtcgtc atgcgggcca gcctggcacg ggcccgctct
    14521 ccggtgcccc gtattttccg tctgggcggc gtcaggcgga gcaggtgagg gccgcgggga
    14581 tctccgcgaa agcctcgtcg acggcccgcg tcaggccgtc gcggccgccg gggccccctt
    14641 gcgtcgtcca gtgcagggag gcggtgcgcc aggcggccac gaagatctcc accgtgaggc
    14701 gcagccgcac cccgtcggtg tcggtgccgg taccggtgcc gacgcgggcg ttgaccgtct
    14761 cgaccagggc gtcggtggtg ttctggcagt agccctggct gtggacctgg acggcggggg
    14821 tggactcggc cagttcgcgg gtggccagga agcggcggtc ccagtcggga tccatggcgg
    14881 ccagcgtggt gccgagggcg cggcggaggg tgtcgagcag ggggccgtcc agctccaggc
    14941 cggcgacgta ctccaggtag gccgaccaga ggtcgctgtc ggcggcgagg gcgacgtcct
    15001 ccttcgacgg atagttccgg aagaaggtcc gcttggagac ctccacctcg tcgcacagct
    15061 cgtccagcgt cgtggcgtcg aagccccgtt cgccgaagag gcggagtgcg gtctcggcca
    15121 gggcctgacg cgtccgcagc ttcttccgtt cgcggagcgg cagggcacgc aggtcacgcg
    15181 ggtcaggcgg gtcgcgcagg tcgtccgtca cgaccgcgag cctaccaccg ccaccacccg
    15241 ggagcgtttg ccgattgacg gctagtgcca ctcagtggca ctgtcgcccc ggtggccgac
    15301 tgcggccgcg aactccccct gaagggaccc gtattcgtga gtaccgtgcc tccgcccccg
    15361 ggccgctccc gcccggcgat cacgctggtc gtcgtgttgc tggccttcgt caccgtgccg
    15421 atgtccatct ccggagccgc cgtcgcactg cccggcatcg gcgaggacct gcacgcggcg
    15481 ggcgctccgc tgcaatgggt catgaacgcc tacaacctga cgttcgcctc gttcacgctg
    15541 gtcgcgggct ccgcggccga cctggtgggc cggcggcgga ccttcgtggc cggcggcgcc
    15601 gtcttcgccc tcggctccct cgccgcggcg gccgcgccgg gcatcgttct gctcgacctc
    15661 gcccgcgccc tgtcgggcat cggcgccgcc ggggtcttcg ccagcggcgg cgcgatcctg
    15721 gccaccacct tcgacggccc cgcgcgcacc cgggccttcg cggcactcgg cagcgccgcc
    15781 ggagtgggcc tcgcggtcgg acccaccctg tcgggcctgc tggtcggcgg actcggctgg
    15841 cgcgccacct tcgggctgca cgccgtcgtc ctcgccgtgg cgctggccgg agccggccac
    15901 ctcgccgaat cccgcgccga acggcgcccg cgcctcgacg tcaccggggc cgtggtcttc
    15961 gtcgcaggcc tgggcgcgct ggtcctcggc tccgtccagg gcccggaatg gggctggtcc
    16021 agccccgggg tggtctccct gctggtcgcc ggcctcggcc tgctcgggta cttcggcgtc
    16081 ctccagtcac gctccgccgc gcccctgctc gacctgaccc tggtgcggaa ccgccgcttc
    16141 ctggccctgt gcatggtccc cgtcgtcgcc accttcggct tcgtgacgct gctgacctac
    16201 ctgcccacct acctcgtcgg cgccggcggc ttctccccgc agcgcgccgg aaccgtcctg
    16261 ctcctgatga ccgccccggt cctcctggcc ccgccactgg cgggagccct ggccaaccgg
    16321 ggcgtctcca cccgcctgct gatcaccgtg gccctcgcct tcttcgccgg cggcaacgcc
    16381 tggctcaccg tgctcggccc ggacaccccc gtcgccgtga tcgccgggcc cctgctcatg
    16441 accggcctcg gcgcgggcat gtccttcggc gtggccgacg gcgcggcgat gagcctcgtc
    16501 cagcccgaac aggccggaat ggccaccggg ttcctcaaca cgatgcgcat cggcagcgag
    16561 gccatcgtca tcgccgtcta cggcgccgtc ctggtcagcc tgatcagcac ccgcgtcggc
    16621 tcccacgacc tggccgccag ggtcgccgcc ggtgacctcg gcggcgccac ctccggcacg
    16681 gccgccgccg gctacacgga cgccctgcac accctgctgt acgcgacggc caccgtctgc
    16741 gccctcggca cggcagccat cgccctggcc ctggcgccac cacggggcgg gcccggcacc
    16801 ccggttgccg ccccgtcctc tgccgccccc acctcggaag acacccgacc gcccagcaaa
    16861 gtcgcctgac cggccacccg ccgtgccgcc cgacccgtcc ggccccgccg gccgatcacc
    16921 acgcgggccg ggcggcaggc tcctcggccc accacagcac cccgctcacc gccaggtacg
    16981 gcacccgccc gcccaccgag cccccgcgct ccagcacatc cgcgaccgcg gtgaggtagg
    17041 cggcgagtga cggggcgtcg tcaccgaaac tcccctcctc gtcgtggtac ttcatcccga
    17101 gccgcccgaa ccccggcccg tccctcccgt cgatgatctg ggcgtcaccc tcactctccg
    17161 cccacggaat ccaccgggga tgccaggacg gctcccccgc ctcctcgggg tccccgaact
    17221 cccgctcctc ctcggtgaac tccatccacc tcgtccagta ccgcacgatc ccggccaccg
    17281 acaacggcgg cttcaccggc agcaccccct cgcccccggc cccgtcgtgg caccccaacg
    17341 aggcccgcaa ctccgccggg aaccgcagac gcagggcagc ctccgccgcc gctgtcgctc
    17401 cgggctcggc gggcggtgcc agtcgcgcgt acgaccccgg cgcccactcc cgcagccacg
    17461 cgtcgatccg cccccacgcc gcccgcaccg cctcggcccc ggcctgcccc gcctcgtcgt
    17521 cactcatacg gcccatccca ccaccaggca gcgacagcgc cgccccggca ctgccgccac
    17581 agtgaccaaa acgtgtccct ccccgcgcac aaccgcgcac cgccctccgc tgtcccacca
    17641 tcagccgaga ggacgaaact ccggccgagg cgcctgcgcg cctgtgcacg ctgtggggag
    17701 agggcgggtt cgatgacgcg gaagacgatg tggagaacgg cggtggccgg cggagcggcg
    17761 atcgtgttca cggggctgac ggcggtgccg gccggggcgg cggagggcgg ggtctcgttc
    17821 acccgggtca aggtgaacaa cggtcagccg atcgtgctcg gggtgaagga gattgttgag
    17881 atacccgctt ccgtacggat gacgacgcgg cacaaattcg atggcggccc cactgtgtac
    17941 ccctaccgca acacccccgc cggtgtcggt gacgcgctct ggagcagcat ccacaccagc
    18001 gaccccacgg tggtggacaa ggcgaagggg atctacgact tcgacctgtc gatccacata
    18061 gacccgcgcc acaaggacgt caccaacggg gacaccggca cttggcggac ccgcgcggag
    18121 atgtggttgg ccgacggcac ctacgacatg gacgacgaga acctcccgct ccaggtcaag
    18181 cgcgccaccc gcctcaccgt caacgccacg ccggaaccgg tgaccaaggg caggaccctc
    18241 accgtgaagg gaaccgtcac ccgggccaac tgggacacgc acacctacca gggctacgcc
    18301 ggccgcaccg tcagcctcca gttcaagccc accggagccg cctcctacaa gacggtcaag
    18361 aaggtgacgt ccgacagcaa gggcggcctc aagaccaccg tgaaggccac cgagtccggg
    18421 acgtggcgct ggacctacta cggcaactcg acctccggag ccaggtcgtc gagcggggac
    18481 cacgtcgccc tgcggtagac cgggcccgtc cgtcaccgca gccccggcag ccggcgtacc
    18541 tcctcgacct tgagcaggcg ggcgaggagg aggtaggcga cggcggtgga gaggacaccg
    18601 gaggccaggg ccacggcggt ggaccacgtc ccggccgtac ccgggccgcc cggtccggag
    18661 accgctcgcg cggcggccca gcccagcccg gccgcgggaa ccgccgcgca gagcagcttc
    18721 ccgtaggcgc ggcccagccc tccggtgccg atccgcccgc cgagcctgcg gcgcagcagg
    18781 cgggcggtga gggcgaggcc ggcgaggtag gagagggtgt acgccccggc catgccgacc
    18841 acggcccagc gtgcgggcag cagtacgtgg caggcgctcg ccagggcgat gtcgacgccg
    18901 gcgatccagg ccgccatgaa gaacggcgta cgggtgtcct cgaaggcgta gaagccgcgc
    18961 agcagcaggt actgggcgga gaacgcgatg aggcccggcc cgaacgcctg gagcatgtgg
    19021 ccgagcgggc gtaccgaggc ggcgtccgcc gcgccgtggg cgaagagcag ggccgcgatc
    19081 tgggggccga gggcgaggaa gaggaaggcg gtgggcacga tgacgacccc gctgatccgc
    19141 agcccgcgcg tcaggtccgc gcgcaggtcc ccgagccggc cctccgcgac ggcccggctc
    19201 atgtggggca gcagcgccgt caccagggag acggtgacga tcgactgggg cagcagccag
    19261 atggtctgcg cgtacgtgta cgcggtgtag cccgcgccgg cctgcgggag ttcctggtcg
    19321 gcggcgttgg cgaagttggt gaccacggtc agcgccacct ggttggccag cacgaacagc
    19381 agcgtccact tcgccgcgtg cacactccgg cccagcccgt tgccccgcca gtcgaaccgc
    19441 ggccggaacc ggaaccccgc ggcccgcgcg aacggcacca gcgccagcgc ctggatcgcc
    19501 acacccgccg tcgtcccgat cccgagcagc cgcacctggt ccgcggtgat gtcctccacc
    19561 ctgccgggcg ccgccatcag ccccaggtac gccgcgaaca tcgccaccag gacgacgttg
    19621 ttgagcaccg gggtccacat catcgccccg aacttctccc gggcgttgag gagctgcccg
    19681 tagatgccga agaggccgta gaagaagatc tgcggcagca ggaaccgggc gaacgtcacc
    19741 gtcagctcga acgcctcatg gctcccgggc gtgtcccgca tgtacaggcc gacgatctcc
    19801 ggcgctgccc acaccgccag cgccgtcccc accccgagca cacagacgac gagcgtcacc
    19861 agccgctgtt cgtaggcccg cccgccgtcc ggctccgtgg ccctggcccg gacgagctga
    19921 ggcaccagga cggcgttgag cgcgccgccg atcagcagcg tgtagagact cgtcggcacc
    19981 gtgttcgccg tgttgtacgt actggccagc agccccgtcc ccagggccgc cgcctgcaac
    20041 acctgccgaa tcagccccgt cgcccgggac accaccgtcc ccaccgccat caacaccgac
    20101 gaccggacca gcccgccacc ggcgcccttc gcccgcccct ccgccgtccg cgcccgtact
    20161 gccgagtccg ccccctgtgt catgcgctca acataatggc cgggcccggc ggcgccgcgt
    20221 cacccgatcg agccggtgcg gtgagccccg gcccggcggg gcgtcaggaa ccggccagcg
    20281 gcgccggagc cggtaccagc ggctccccgt tgagctgggt ctcgcccttc agggaccacc
    20341 acagttcgcc ctcggtcgtc aggaaggggg cccacgtgcc gcccaccgcc ccgcccttct
    20401 ccaggacgtc ggcgacctcg gtcaggtagg ccgccaggga cggccagccg tcggtgaaga
    20461 cgccgcagtc gtcgtggtag gccatgccga ggcggccctg ggcggggccc gggcgcatgt
    20521 cgatgatctg ggcgtcgccg tcgctctggg cccaggggat ccactggggg tgccaccagg
    20581 gctcctcgcc ctcgggctcc ggctcgtcct cgtcggcgcg gttggcctcg tcgatctcga
    20641 cgcacatctg ccagtggccg acgatcctgg cgacgggctc gggcgggcgc agcggcaggc
    20701 agttgtccca gtggcgcagg ccgtcgtggc aggcgaggga ggcgaggagg tccgccggga
    20761 aacgaacccc catctcggcc tgggccgcct cgaccgccgc cgggtcggcg ggcggcgcca
    20821 gcacctcgta ggagtccggg gcgtgggcgc gcatccacgc gtcgatgcgc gcccaggcgt
    20881 cccgcaccgc cccggcgcgc tcctcgtccc cggcgggtcc cgtcgttccg tgatcgctca
    20941 tgtgtccgat cccaccacac gccaccgaca acgccggacg ggccgtcagt cgcggggtgc
    21001 gtggccgtaa gggaaggccc gggggaggca ggcgtacgtc ccgccgcccc cggacgcccg
    21061 cgagagggcg acggccggtg cccgggaggg gctcagccgg cccgcctctc cgcttccagc
    21121 gtctcgcgca gccgctccag ggtctcccgc atggtctcgg cgttgtgcgc gctccggtcc
    21181 cagacgccgc tgaccgccga accgaggaac cacaggagcc ggttgcgctg gtccacggcc
    21241 gtctcggtca cctcggtcgc ggtgccgtcc ccgaccgggc ggaagcggta gtcccaggtg
    21301 gccaccggca tcccccagaa ccgcacccgg aaggtgaacc gctcaccgga ccgggccacc
    21361 atcacccggc accgcgtcga ccagctccgg ccgctcggcc ccttgttggt ccccttgaac
    21421 tcggcgccca ccggcgcggg cccgacgccc gccgccgtcc gcacgcactc cggactccac
    21481 cgccccatgg acgccacgtc ggcgacccgc tcgtagaccg ccttcggctc cgcctcgatc
    21541 acggccgcca cggagacctc cgctgtgctc ctcatgtccc tcaaccccct ctgttgtacg
    21601 acaacctgtc agcacgacca ccccacccaa ccaaagccgc ccccgcgcgg ccaccctcgg
    21661 gcccccgggg agaccaccct cacgtgtact accgtccgga ggatgagcga gaacgtgtac
    21721 gtgggcaacg cccccgagga agccgcgctg gacgccggct ggatcatggg ccacttcaag
    21781 gcgccggacg acccgcgcca caacgaggcc gtggagatca aatggggcgt ccacgaggcg
    21841 ggcgagcggc gcgccgcctg ggtgcgcggg gaggagcggc aggcgctcct ggtcctcatc
    21901 agcggacggt tccgcatgga gtttcccggg caggacgtgg tcctgagcga gcaggggcag
    21961 tacgtgatct ggggcaaggg cgtggaccac tcctgggagg ccgaggagcc gtccgtcgtc
    22021 atgaccgtgc gctggccctc cgtgccgggc taccgcgtct ccccctgaac cgccccctcc
    22081 gaccaccccc ggccggagcg gggagacgac cccggcggtg agcggtgagg agagggcgga
    22141 gggtggcgcc gacgggtcag cagagggcgc gtcggccggg gtgcgcgaac ggcatccgct
    22201 ccgcccgcgc acccacgcgc ccacccttcg gctccgaccg tcagctaccc ggcctcaccc
    22261 gcgccaccct cggcgtcacc cgaacg
//
