LOCUS       NZ_CP049945            10399 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces koyangensis strain SCSIO 5802 chromosome, complete
            genome.
ACCESSION   NZ_CP049945
VERSION     NZ_CP049945.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces koyangensis
  ORGANISM  Streptomyces koyangensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces
            aurantiacus group.
REFERENCE   1  (bases 1 to 6861301)
  AUTHORS   Ding,W.
  TITLE     Genome mining and metabolic profiling illuminate the polycyclic
            tetramate macrolactams from Streptomyces koyangensis SCSIO 5802
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6861301)
  AUTHORS   Ding,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-MAR-2020) Chinese Academy of Sciences, Key Laboratory
            of Tropical Marine Bio-resources and Ecology, No.164 Xingang west
            Road, Guangzhou, Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016803985.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:33:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,078
            CDSs (total)                      :: 5,988
            Genes (coding)                    :: 5,861
            CDSs (with protein)               :: 5,861
            Genes (RNA)                       :: 90
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 127
            CDSs (without protein)            :: 127
            Pseudo Genes (ambiguous residues) :: 0 of 127
            Pseudo Genes (frameshifted)       :: 60 of 127
            Pseudo Genes (incomplete)         :: 90 of 127
            Pseudo Genes (internal stop)      :: 7 of 127
            Pseudo Genes (multiple problems)  :: 29 of 127
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:34:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1148591
            Orig. end                         :: 1158990
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP049945.1.
            Bacteria and source DNA available from Deep sea sediment.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="4"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    complement(116..131)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.95"
                     /tool="antismash"
     gene            complement(293..1384)
                     /locus_tag="G9U55_RS04875"
                     /old_locus_tag="G9U55_04920"
     CDS             complement(293..1384)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982886.1"
                     /locus_tag="G9U55_RS04875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_04920"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_129850364.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 8.7e-15, bitscore:
                     53.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEDMVLHVKGRILVGPEEARDELWVVGGRITFTRPPGAREVRTV
                     EGWALPGLVDAHCHVGLDRHGPVAADVAEKQALTDRDAGALLLRDAGSPSDTRWMDDRD
                     DLPRVIRAGRHIARTRRYIRNYAHEIEPDQLVAYVGQEARRGDGWVKLVGDWIDRGAGD
                     LTPCWPREAVEAAIAEAHRLGARVTAHCFAEDSLRDLVEAGIDCIEHATGLTEDTIPLF
                     AERGVAIVPTLVNIATFPDLAAGGEAKFPDWSAHMRRLYERRYDTVRAAWDAGIPVFVG
                     TDAGGSLPHGLVAAEVAELVTAGIPPLDALSATAWGARDWLGRPGLTEGAPGDLVVYAS
                     DPRADVRVLAAPRRVVIGGKVVA"
     gene            1459..2574
                     /locus_tag="G9U55_RS04880"
                     /old_locus_tag="G9U55_04925"
     CDS             1459..2574
                     /NRPS_PKS="Domain: Aminotran_5 (73-292). E-value: 1.1e-29.
                     Score: 95.4. Matches aSDomain:
                     nrpspksdomains_G9U55_RS04880_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003947419.1"
                     /locus_tag="G9U55_RS04880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_04925"
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="WP_203214027.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.4e-22, bitscore:
                     78.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPLLDLTPLTAAHFANIERRVAALLSTSQDVVITQGEALLPLE
                     GCIRGVAGPDTTALNVITGPYGQTFGDWLRDCGARVIDLAVPYDSAVSAAQVAEALAEH
                     PETGFVSLVHAEAATGNTNPVAEIGRVVRDHGALFMVDAVASVGAEPLLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWQRMAANPQAPRRSYLSLLDWKERWIDAGRTALLHAP
                     AQLEMLALQACVERIEDEGLETVIGRHTRAAAATRAGVKALGGGFAPYVREARDAAPVA
                     TTLRAPEGVDASELVARALAADPVLPLVAGGGSLAKEMIRVNHYGTAAAGSTVHSSLSA
                     LGAALTDLTGRSVDPDAARRAATAAWERPAG"
     aSDomain        1678..2334
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G9U55_RS04880_Aminotran_5.1"
                     /evalue="1.10E-29"
                     /label="G9U55_RS04880_Aminotran_5.1"
                     /locus_tag="G9U55_RS04880"
                     /protein_end="292"
                     /protein_start="73"
                     /score="95.4"
                     /tool="antismash"
                     /translation="LRDCGARVIDLAVPYDSAVSAAQVAEALAEHPETGFVSLVHAEAA
                     TGNTNPVAEIGRVVRDHGALFMVDAVASVGAEPLLPDAWGVDLCVIGAQKAMGGPAGVS
                     AVSVSERAWQRMAANPQAPRRSYLSLLDWKERWIDAGRTALLHAPAQLEMLALQACVER
                     IEDEGLETVIGRHTRAAAATRAGVKALGGGFAPYVREARDAAPVATTLRAPEGVDA"
     misc_feature    2714..2727
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.78"
                     /tool="antismash"
     misc_feature    2834..2849
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     misc_feature    complement(2845..2860)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    2855..2870
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    2894..2912
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.88"
                     /tool="antismash"
     misc_feature    2959..2970
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.51"
                     /tool="antismash"
     misc_feature    2989..3001
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     misc_feature    3015..3027
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            3068..3574
                     /gene="ectA"
                     /locus_tag="G9U55_RS04885"
                     /old_locus_tag="G9U55_04930"
     CDS             3068..3574
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008412174.1"
                     /locus_tag="G9U55_RS04885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_04930"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_225930302.1"
                     /transl_table=11
                     /translation="MKEMPEDLRLDHPGVEDGAAIWRIARDSRTLDLNSSYSYLLWCRD
                     FAGTSVVARAAGGEPVGFVTGYFRPERPHTLVVWQVAVDASQRGRGLAAALLDGLTDRL
                     REKGRLDGIETTITPGNTPSERLFTSYAKRHGAELEREVLFGAGLFPDGGHDPEVLYRI
                     GPFTD"
     gene            3695..4966
                     /gene="ectB"
                     /locus_tag="G9U55_RS04890"
                     /old_locus_tag="G9U55_04935"
     CDS             3695..4966
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0047307 - diaminobutyrate-pyruvate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-366). E-value: 2.8e-75.
                     Score: 245.3. Matches aSDomain:
                     nrpspksdomains_G9U55_RS04890_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156968.1"
                     /locus_tag="G9U55_RS04890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_04935"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_101280517.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.8e-79, bitscore:
                     265.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITPPALSVFETLESEVRSYCRSWPAVFDRAQGSYLYDEDGHTY
                     LDFFAGAGALNYGHNNPVLKRALIDYIERDGITHGLDMGTTAKRAFLETFQNVLLRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVQDFLWFERLLEDQGSGLNTPAAVIVETIQGEGGINVARP
                     EWLRALADLCKRRDMLLIVDDIQMGCGRTGPFFSFEEAGITPDIVTLSKSIGGYGLPMS
                     LCLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALDAYWSDGQMEKQTLARGEQVEQALT
                     AILDEHGGESIVSVRGRGLVWGMEFADKSRAGAVSKRAFELGLLVETSGPESEVVKLLP
                     PLTVSPDELDEGLRILARAVRETA"
     aSDomain        3779..4792
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G9U55_RS04890_Aminotran_3.1"
                     /evalue="2.80E-75"
                     /label="G9U55_RS04890_Aminotran_3.1"
                     /locus_tag="G9U55_RS04890"
                     /protein_end="366"
                     /protein_start="28"
                     /score="245.3"
                     /tool="antismash"
                     /translation="FDRAQGSYLYDEDGHTYLDFFAGAGALNYGHNNPVLKRALIDYIE
                     RDGITHGLDMGTTAKRAFLETFQNVLLRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     RESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVQDFLWFER
                     LLEDQGSGLNTPAAVIVETIQGEGGINVARPEWLRALADLCKRRDMLLIVDDIQMGCGR
                     TGPFFSFEEAGITPDIVTLSKSIGGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAAALDAYWSDGQMEKQTLARGEQVEQALTAILDEHGGESIVSVRGRGLVWGMEFA"
     gene            5001..5399
                     /locus_tag="G9U55_RS04895"
                     /old_locus_tag="G9U55_04940"
     CDS             5001..5399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003947422.1"
                     /locus_tag="G9U55_RS04895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_04940"
                     /product="ectoine synthase"
                     /protein_id="WP_203214029.1"
                     /sec_met_domain="ectoine_synt (E-value: 6.4e-55, bitscore:
                     182.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIENTDRHVKSASGTWESKRIVLAKEKVGFSLHETILY
                     AGTETDMWYANHIEAVLCIEGEAELTNRETGETHWIEPGTMYLLNGHEKHTLRPKTDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEED"
     gene            5403..6299
                     /gene="thpD"
                     /locus_tag="G9U55_RS04900"
                     /old_locus_tag="G9U55_04945"
     CDS             5403..6299
                     /EC_number="1.14.11.55"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010637026.1"
                     /locus_tag="G9U55_RS04900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_04945"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_101280518.1"
                     /sec_met_domain="PhyH (E-value: 2.4e-37, bitscore: 127.7,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVASERTDLYPSRTATEVTIPRKDPVVWSPQDAPGPITRSDLQS
                     YDDNGFLAVEELITPEEVGVYRAELDRLVADPLIRADERAIVEPKSEKVRSVFEIHKIS
                     EIFAGLVRDERLLGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPR
                     MRAVSVSIALTENYDTNGGLMIMPGSHRTYVGCNGVTPKDNYKRSLQMQDAGIPSDEVL
                     TEFADRHGIKLFTGKAGSATWFDCNAMHGSGDNITPYPRSNVFIVFNSVDNAAEEPFAA
                     PVRRPEFIGARDFTPVR"
     gene            complement(6465..7532)
                     /locus_tag="G9U55_RS04905"
                     /old_locus_tag="G9U55_04950"
     CDS             complement(6465..7532)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045205.1"
                     /locus_tag="G9U55_RS04905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_04950"
                     /product="alkene reductase"
                     /protein_id="WP_203214030.1"
                     /transl_table=11
                     /translation="MSTAFEPLDLSGTKLPHRIAMAPMTRSRSGAAGVPTALMAEYYAQ
                     RASAALIVTEGIQPSAVGQGYPDTPGLHSAEQVTGWRAVTSAVHAAGGRIFAQLMHAGR
                     IGHPSLLPEGEVNVAPSAVAATGQVYTAEGPKDFVTPRELTDDEVRATLADYVTAARNA
                     VDAGFDGVELHGANGYLIHQFLAPGSNRRTDGWGGSVEGRIRFAAEVTEAVVAEIGAAR
                     TALRLSPGNTFNSIEEPEPEPEYTALVARIAPLGLAYLHLAEDVPARRALTLRLRELFD
                     GPLMLNPAGSPTGPEALALVEEGTADLVSYGQLFLANPDLPARLRAGGPFNEAQRATMY
                     GGGAEGYTDYPALTG"
     misc_feature    complement(7586..7596)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            7704..8222
                     /locus_tag="G9U55_RS04910"
                     /old_locus_tag="G9U55_04955"
     CDS             7704..8222
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010637029.1"
                     /locus_tag="G9U55_RS04910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_04955"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_203214031.1"
                     /transl_table=11
                     /translation="MNDTTGPEQAPCTRPAEGGTAPPGGLVGHLVTRVARLHRTAAGRA
                     LRESGLYPGQEIVLGHLWEAGGPVRQSDLIKAVELDPSTVTKTLQRLEQSGHVTRAPDP
                     ADRRAVLVEATELSCALSRQVESVWAGLEEHALAGLTPADRAELTRLLAAVEANLCDRA
                     GGCSQAEAE"
     misc_feature    complement(7751..7770)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.37"
                     /tool="antismash"
     gene            complement(8233..9282)
                     /locus_tag="G9U55_RS04915"
                     /old_locus_tag="G9U55_04960"
     CDS             complement(8233..9282)
                     /NRPS_PKS="Domain: Aminotran_5 (55-343). E-value: 7.7e-23.
                     Score: 72.9. Matches aSDomain:
                     nrpspksdomains_G9U55_RS04915_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018895195.1"
                     /locus_tag="G9U55_RS04915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_04960"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_203214032.1"
                     /sec_met_domain="Aminotran_5 (E-value: 8.1e-18, bitscore:
                     62.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLARSLAEDEFKPSLTHLATASTGLLPLSAARAVHEAVDAAAAG
                     TPPDMFGARDAARASFARLMGVPATRVATGSSVATFTGLIAASLPDGAEVLTAEGDFSS
                     LVNPFHVRPGLTVRTVPLERIAEHVTEATALVAVSAVQSADGRRADLAAVREAARAHGA
                     RTLIDASQAAGWDFFDAGAYDYTVAVGFKWLLAPKGTAFLTVPEEPGALPPLLAGWVAG
                     DSPFDSCYGPVTGLAPDARRYDESPAPLVWTGARHALALLERIGTEAIGAHDVALADRF
                     RERLTRAGHAPVPAPGSAIVSVPGLGERAAALGGQGITVSDRAGMLRAAFHLYNTESDV
                     DRLVAALDG"
     aSDomain        complement(8254..9117)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G9U55_RS04915_Aminotran_5.1"
                     /evalue="7.70E-23"
                     /label="G9U55_RS04915_Aminotran_5.1"
                     /locus_tag="G9U55_RS04915"
                     /protein_end="343"
                     /protein_start="55"
                     /score="72.9"
                     /tool="antismash"
                     /translation="AARASFARLMGVPATRVATGSSVATFTGLIAASLPDGAEVLTAEG
                     DFSSLVNPFHVRPGLTVRTVPLERIAEHVTEATALVAVSAVQSADGRRADLAAVREAAR
                     AHGARTLIDASQAAGWDFFDAGAYDYTVAVGFKWLLAPKGTAFLTVPEEPGALPPLLAG
                     WVAGDSPFDSCYGPVTGLAPDARRYDESPAPLVWTGARHALALLERIGTEAIGAHDVAL
                     ADRFRERLTRAGHAPVPAPGSAIVSVPGLGERAAALGGQGITVSDRAGMLRAAFHLYNT
                     ESDVDRL"
     gene            complement(9414..10139)
                     /locus_tag="G9U55_RS04920"
                     /old_locus_tag="G9U55_04965"
     CDS             complement(9414..10139)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003947427.1"
                     /locus_tag="G9U55_RS04920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G9U55_04965"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_203214033.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFDKALAAFPHRDRIEVVHRSFELDP
                     ARPKGDPELVLPMLAKKYGMSEAQAAEAERNLGQNAAAEGLPYLTEGRDHGSTFDMHRL
                     LHLAKARGRQDELLAVLYRANFAETETVFGDDERLVALAVEAGLKEAEAREVLADEQRY
                     AAEVRADERAASELGANGVPFFVLDRRYGVSGAQPADVFTQALTQAWESHVPASGLATP
                     AGAEGGEACGPDGCEVPKN"
ORIGIN
        1 ccgccggggc cgcacctggg gacaggcggc cgccgacgac gtcgttgccg gaatctttac
       61 gcactgcggg tgaaggggcg acaacctggg gcgacttcac tccaaagggt ggttttggtg
      121 cagacgttcg acccgatcgg cacgaccgtt cccccacgtc acccctgacc gccgtttccg
      181 ggcccccgag gggcgtacgg acggcgtacg cgggcgcgga cacgcgtcgg gggccagagc
      241 acaacgacgc tgctccggcc cccgtaacgg cccgtcaaca cccttctcgc ggtcaggcga
      301 cgaccttgcc gccgatcacg acccggcggg gcgccgccag cacccggacg tcggcgcgcg
      361 gatcgctcgc gtagaccacc aggtcgcccg gcgccccctc ggtcagcccg gggcgcccca
      421 gccagtcgcg ggcgccccac gccgtggcgg agagggcgtc gagcggcggg atgccggcgg
      481 tgaccagttc ggcgacctcg gcggcgacca ggccgtgcgg gaggctgccg cccgcgtcgg
      541 tgccgacgaa gaccgggatg ccggcgtccc aggcggcgcg gaccgtgtcg taccggcgct
      601 cgtacagccg ccgcatgtgg gccgaccagt cggggaactt cgcctcgccg cccgccgcga
      661 ggtcggggaa ggtggcgatg ttgaccaggg tggggacgat ggcgacgccg cgttcggcga
      721 agagcgggat ggtgtcctcg gtgagcccgg tggcgtgctc gatgcagtcg atgcccgcct
      781 cgaccaggtc gcgcagcgag tcctcggcga agcagtgggc ggtgacccgg gcgccgagcc
      841 ggtgcgcctc ggcgatggcg gcctcgaccg cctcgcgggg ccagcacggc gtcaggtcgc
      901 ccgcgccccg gtcgatccag tcgccgacca gcttgaccca gccgtcgccg cgccgcgcct
      961 cctggccgac gtaggcgacg agttggtccg gctcgatctc gtgggcgtag ttgcggatgt
     1021 agcggcgggt gcgcgcgatg tggcgcccgg cccggatgac gcggggcagg tcgtcgcggt
     1081 cgtccatcca gcgggtgtcg ctcggagaac cggcgtcgcg cagcagcagc gccccggcgt
     1141 cgcggtcggt gagcgcctgc ttctcggcga cgtcggcggc gaccgggccg tgccggtcca
     1201 gtccgacgtg gcagtgggcg tcgaccaggc ccggcagcgc ccacccctcg acggtccgca
     1261 cctcacgggc gcccggcggc cgcgtgaagg tgatccgccc gcccaccacc cagagttcgt
     1321 ccctggcctc ctcgggaccg accagtatcc ggcccttcac gtgcagcacc atgtcttcgc
     1381 tcatgcacgg cagcgtagga cccggtgggt acgctcggac cggcagcccg acgatcgacc
     1441 ggcgaagaga gcacccccgt gacccacccc ctcctggacc tgaccccgct gaccgccgcg
     1501 catttcgcga acatcgagcg ccgcgtcgcg gcgctgctct ccacctcgca ggacgtcgtc
     1561 atcacccagg gtgaggcgct gctgccgctg gagggctgca tccgcggcgt ggcgggcccg
     1621 gacaccaccg ccctcaacgt gatcaccggc ccgtacgggc agaccttcgg cgactggctg
     1681 cgcgactgcg gggcgcgtgt gatcgacctg gcggtcccct acgactcggc tgtcagcgcc
     1741 gcccaggtcg ccgaggcgct ggcggagcac ccggagaccg gcttcgtctc gctggtgcac
     1801 gccgaggcgg cgaccgggaa caccaacccg gtggcggaga tcggccgggt ggtgcgcgat
     1861 cacggcgcgc tcttcatggt ggacgcggtg gcctcggtcg gcgccgagcc gctgctcccg
     1921 gacgcctggg gcgtggacct ctgcgtgatc ggcgcccaga aggcgatggg cgggcccgcc
     1981 ggggtctcgg cggtctcggt gagcgagcgg gcctggcagc ggatggcggc caacccgcag
     2041 gcgccgcgcc gctcgtacct ctccctgctg gactggaagg agcggtggat cgacgccggc
     2101 cgcaccgccc tgctgcacgc cccggcccag ctggagatgc tggcgctcca ggcgtgcgtg
     2161 gagcggatcg aggacgaggg cctggagacg gtgatcgggc ggcacacccg ggcggcggcg
     2221 gccacccggg ccggcgtgaa ggcgctcggc ggcggcttcg cgccgtacgt ccgggaggcg
     2281 cgggacgcgg cgccggtggc gaccacgctg cgggcgccgg agggcgtgga cgcctcggag
     2341 ctggtggcgc gggcgctggc ggcggacccg gtgctgccgc tggtggcggg cggcgggtcg
     2401 ctggccaagg agatgatccg ggtcaaccac tacggcacgg ccgcggccgg ctccacggtc
     2461 cactcctccc tctccgcgct gggggcggcg ctgaccgacc tcacgggccg gtcggtcgac
     2521 ccggacgcgg cgcggcgcgc ggcgaccgcg gcctgggagc gccccgcggg ctgaccttcc
     2581 ggcaccggcc ccggcgggcc gtccggcgcg cggctcacgc cgtgcgcggg gcggcccgtt
     2641 ccgcttttcg tgtcccgggc acaccgaagt ccgcaccgac ttcggcgcgg acagcgaacg
     2701 atattcttat cgatagacct attacaggga attccgaatt ctttcgcact caccttcccc
     2761 tattcgtctg cccgctctcc ccgaagctaa acgcatcgat tttccggaca ccgaaaccgc
     2821 gtaattcgga cgcgtcacgc atgcgttacg cacttgtgac tgactccaca cggtgcccgt
     2881 ttcgcgcctt atatgcagga caaatcacca tcttcggaca gctgttcgcg caggcgcacc
     2941 cccgcgcccg ataacacaga aagcgctgtc atgtaaccct gacccgcgat gcatttttca
     3001 gagtcgatcg gtaaattcaa tttgcatgac cgccgcacaa gccgaccttg aacgtggccg
     3061 atccaccatg aaggaaatgc cagaggattt gcgcctggac cacccgggcg tcgaggacgg
     3121 ggcagccatc tggcgcatcg cccgtgactc gcgcaccctc gacctcaact cctcctacag
     3181 ctacctcctg tggtgtcgcg acttcgccgg cacctccgtg gtggcccgcg ccgccggcgg
     3241 cgagccggtc gggttcgtga ccgggtactt ccggcccgag cgcccgcaca ccctcgtcgt
     3301 ctggcaggtc gccgtggacg cctcgcagcg cgggcggggc ctcgccgccg ccctgctgga
     3361 cggtctcacc gaccggctcc gtgagaaggg gcggctggac ggaatcgaga ccaccatcac
     3421 cccgggcaac acgccctccg agcgcctctt cacctcctac gccaagcgcc acggcgccga
     3481 gctggagcgc gaggtcctct tcggtgccgg actctttccc gacggggggc acgaccccga
     3541 ggtgctgtac cgcatcggac cgttcaccga ctgacaggcg cgaacgcccg cacagctact
     3601 ccaggtccgg ccggaaggca agcctccggc cgcccttccg cacgtatccc tgacttccgc
     3661 cccgcttcac cccccatctc ccaggagagc agtcgtgacc atcaccccgc ccgcactgag
     3721 cgtcttcgag acccttgagt cggaggtacg gagctactgc cgcagctggc ccgccgtctt
     3781 cgaccgggcc cagggcagct acctgtacga cgaggacggc cacacctacc tcgacttctt
     3841 cgccggcgcc ggcgccctca actacggcca caacaacccg gtgctgaaac gcgcgctgat
     3901 cgactacatc gagcgcgacg gcatcaccca cggcctggac atgggcacca ccgccaagcg
     3961 cgcgttcctg gagaccttcc agaacgtgct gctgcgcccg cgtgacctgc cgtacaaggt
     4021 catgttcccc ggcccgacgg gcaccaacgc cgtcgagtcg gcgctgaagc tggcccggaa
     4081 ggtcaagggc cgcgagtcca tcgtctcctt caccaacgcc ttccacggca tgtcgctggg
     4141 ctcgctcgcc gtgaccggca acgccttcaa gcgcgccggg gccggcatcc cgctggtgca
     4201 cggcacgccg atgcccttcg acaactactt cgacggcacc gtccaggact tcctctggtt
     4261 cgagcggctg ctggaggacc agggctcggg cctcaacacc ccggccgcgg tcatcgtcga
     4321 gaccatccag ggcgagggcg gcatcaacgt ggcccggccc gagtggctgc gcgccctcgc
     4381 cgacctgtgc aagcgccgcg acatgctgct gatcgtcgac gacatccaga tgggatgcgg
     4441 ccgcaccggc ccgttcttct ccttcgagga ggcgggcatc accccggaca tcgtcaccct
     4501 gtcgaagtcc atcggcggct acggcctgcc catgtcgctc tgcctcttca agccggagct
     4561 ggacatctgg gagccgggcg agcacaacgg caccttccgg ggcaacaacc cggccttcgt
     4621 caccgccgcc gccgcgctgg acgcgtactg gagcgacggc cagatggaga agcagaccct
     4681 cgcccggggc gagcaggtcg agcaggcgct caccgccatc ctcgacgagc acggcggcga
     4741 gtccatcgtc tccgtccgcg gccggggtct ggtctggggc atggagttcg ccgacaagtc
     4801 ccgcgcgggc gccgtctcca agcgcgcctt cgagctgggt ctgctggtcg agacttccgg
     4861 gccggagagc gaggtggtca agctgctgcc gccgctcacc gtgagcccgg acgaactgga
     4921 cgagggtctg cgcatcctcg cccgcgccgt ccgagagacg gcctgacaca caacgacgga
     4981 agaaagggca cgaccacact gtgatcgtcc gatcgttcaa ggacatcgag aacaccgacc
     5041 ggcacgtcaa gtcggcgtcc ggcacctggg agagcaagcg catcgtgctc gccaaggaga
     5101 aggtcggttt ctcgctgcac gagaccatcc tctacgcggg caccgagacc gacatgtggt
     5161 acgccaacca catcgaggcc gtgctctgca tcgagggtga ggccgagctg accaaccgcg
     5221 agacgggcga gacccactgg atcgagcccg gcacgatgta cttgctgaac ggccacgaaa
     5281 agcacaccct gaggccgaag acagattttc gctgcgtctg cgtcttcaac cctcccgtga
     5341 ccggacggga ggaccacgac gagaacggcg tctacccgct gctgaccgag gaggactgag
     5401 tcatgactgt cgcgtcggaa cgcaccgatc tctacccgag ccggactgca accgaggtga
     5461 cgatcccgcg caaggacccc gtggtgtggt ccccgcagga cgcccctgga cccattacgc
     5521 ggtccgacct gcagtcgtac gacgacaacg gcttcctcgc cgtcgaggag ctgatcaccc
     5581 ccgaggaggt cggcgtctac cgggccgagc tggaccggct ggtcgccgac cccctcatcc
     5641 gggccgacga gcgggccatc gtcgagccca agtcggagaa ggtccgctcg gtcttcgaga
     5701 tccacaagat cagcgagatc ttcgccggcc tggtccgtga cgagcggctg ctgggccggg
     5761 cccggcagat cctcggctcg gacgtctacg tccaccagtc ccggatcaac gtgaagccgg
     5821 gcttcggcgc ctccggcttc tactggcact cggacttcga gacctggcac gccgaggacg
     5881 ggctgccgag gatgcgcgcg gtgtccgtct cgatcgcgct gaccgagaac tacgacacca
     5941 acggcggcct catgatcatg ccggggtcgc accgcaccta cgtggggtgc aacggcgtga
     6001 cgccgaagga caactacaag cggtcgctcc agatgcagga cgcgggcatc ccctccgacg
     6061 aggtgctgac cgagttcgcc gaccggcacg gcatcaagct cttcacgggc aaggccgggt
     6121 cggccacctg gttcgactgc aacgccatgc acggctccgg ggacaacatc accccgtacc
     6181 cgcgcagcaa cgtgttcatc gtcttcaaca gcgtcgacaa cgctgctgag gagcccttcg
     6241 cggcgccggt gcggcgcccg gagttcatcg gggcgcgtga cttcactccg gtgaggtgag
     6301 ccggtgacgt cccgcttcac ccatgtggag caggcacacc ggacgagccg ctgacggcgg
     6361 cgcatcacgc accggcgcac acggcgcccg ggccacggga ccgggggcgg ccacaggcgg
     6421 gccgctcccg gtccggttgc gttctacggg gcttttcgcc gtggtcagcc ggtcagggcc
     6481 gggtagtcgg tgtacccctc ggccccgccg ccgtacatgg tggcgcgctg cgcctcgttg
     6541 aacggtcccc cggcgcgcag ccgcgcgggc aggtcggggt tggccaggaa gagctgcccg
     6601 tagctgacca ggtcggcggt gccctcctcg accagggcca gcgcctcggg gccggtcggg
     6661 ctgccggccg ggttgagcat cagcgggccg tcgaagagct cgcgcaggcg cagggtgagc
     6721 gcccggcggg cggggacgtc ctcggcgagg tgcaggtagg cgaggccgag cggggcgatc
     6781 cgggcgacca gcgcggtgta ctccggctcc ggctcgggct cctcgatgct gttgaaggtg
     6841 ttgccgggcg agaggcgcag ggcggtcctg gcggcgccga tctcggcgac caccgcctcg
     6901 gtgacctcgg ccgcgaaccg gatgcggccc tcgaccgagc cgccccagcc gtcggtgcgg
     6961 cggttggagc cgggggcgag gaactggtgg atgagatacc cgttggcgcc gtgcagctcg
     7021 accccgtcga agccggcgtc aaccgcgttg cgggcggccg tgacgtagtc ggcgagggtc
     7081 gcgcggacct cgtcgtcggt cagctcacgc ggggtgacga agtccttggg gccttcggcg
     7141 gtgtagacct ggccggtcgc ggcgaccgcg gacggggcga cgttgacctc gccctcgggc
     7201 agcagcgagg gatggccgat ccggccggcg tgcatgagct gggcgaagat ccggccgccg
     7261 gcggcgtgca ccgcggaggt gaccgcgcgc caccccgtca cctgttcggc cgaatggagg
     7321 ccgggggtgt ccgggtaccc ctggccgacg gcggagggct gaatgccctc ggtgacgatc
     7381 agggcggccg aggcgcgctg cgcgtagtac tcggccatga gcgccgtcgg cacgccggcc
     7441 gcgccggagc ggctgcgggt catgggggcc atggcgatgc ggtgcggaag cttggtgccg
     7501 gacaggtcga ggggctcgaa ggcagtgctc acgggcggtc tccagtgggg gaacgggtgg
     7561 ttccgggcag agcggggccc cggccgacac attgcatggt cggccaatca atcaggccgg
     7621 gagccactgt aacccattaa ttggccgacc aaaggtatag tcgggcggag accgggacga
     7681 gcacgaccca gcgggagacg tggatgaacg acacgaccgg ccccgagcag gccccctgta
     7741 cccggcccgc cgaggggggc acggccccgc ccggcgggct ggtcggccat ctcgtcaccc
     7801 gggtggcgcg gctgcaccgg accgccgccg ggcgggcgct gcgcgagtcg ggtctctacc
     7861 cgggccagga gatcgtcctc ggccacctct gggaggcggg cggtccggtc cgccagtccg
     7921 acctgatcaa ggcggtcgaa ctcgacccct ccacggtgac caagaccctc cagcggctgg
     7981 agcagtccgg gcacgtcacc cgcgcccccg accccgccga ccggcgggcc gtcctggtcg
     8041 aggcgaccga gctgagctgc gccctgagcc gccaggtcga gtcagtctgg gccggccttg
     8101 aggagcacgc cctggccggt ctcacccccg ccgaccgcgc cgaactgacg cgcctgctgg
     8161 cggcggtgga ggccaacctc tgcgaccggg cgggcggttg ctcccaggcg gaggcggagt
     8221 agcccgcgcg gctcagccgt cgagcgcggc caccagccgg tcgacgtcgc tctcggtgtt
     8281 gtacaggtgg aaggcggccc ggagcatccc cgcccggtcg gagacggtga tcccctgccc
     8341 cccgagggcc gccgcccgct cccccagtcc cggtacggag acgatggccg agccgggggc
     8401 cggcacgggg gcgtgtccgg cgcgggtcag ccgctcccgg aagcggtcgg cgagcgccac
     8461 gtcgtgggcg ccgatcgcct cggtcccgat ccgctccagc agggcgaggg cgtgccgcgc
     8521 gccggtccag acgagcgggg cgggactctc gtcgtagcgg cgcgcgtcgg gggccaggcc
     8581 ggtgacgggt ccgtagcagc tgtcgaacgg ggagtcgccc gcgacccagc ccgcgaggag
     8641 cggcggcagg gcgccgggct cctccgggac ggtgaggaag gcggtgccct tcggggcgag
     8701 cagccacttg aacccgacgg cgaccgtgta gtcgtaggcc ccggcgtcga agaagtccca
     8761 gcccgcggcc tgggaggcgt cgatcagggt gcgggcgccg tgggcgcggg ccgcctcgcg
     8821 gacggcggcg aggtcggcgc ggcggccgtc ggcggactgc acggcgctga ccgcgaccag
     8881 ggcggtcgcc tcggtgacgt gctcggcgat ccgctccagc ggcacggtac gtacggtcag
     8941 tcccggccgg acgtggaagg ggttgaccag cgagctgaag tcgccttcgg cggtgagcac
     9001 ttcggcgccg tcgggcagcg aggcggcgat caggccggtg aaggtcgcca cggacgatcc
     9061 ggtggcgacg cgggtggcgg ggacgcccat cagccgggcg aaggaggccc gggcggcgtc
     9121 ccgggcgccg aacatgtcgg gcggggtgcc ggccgcggcg gcgtcgaccg cctcgtgcac
     9181 ggcccgggcc gcgctcagcg gcaggagacc ggtgctggcg gtcgccaggt gcgtcaggga
     9241 gggcttgaac tcgtcttcgg caaggctgcg ggcgagatcc atgcggccac tgtgcaccct
     9301 cgcgcggcgg ccgtccatga tgcggcggcc gccgaaccgt ccctggtggg tacgggtccg
     9361 gcccgccgcc cgccggagcg gatggcgacg ggccgggcgg gcgcggggcg cggtcagttc
     9421 ttcgggacct cgcagccgtc ggggccgcag gcctcgccgc cctcggcgcc ggccggggtg
     9481 gcgagaccgg aggcggggac gtggctctcc cacgcctggg tgagcgcctg cgtgaagacg
     9541 tcggcgggct gggcgccgga gacgccgtac cgccggtcga ggacgaagaa cgggacgccg
     9601 ttggcgccca gttcgctggc ggcgcgctcg tcggcgcgga cctcggcggc gtaccgctgc
     9661 tcgtcggcga ggacctcgcg ggcctcggcc tccttcagcc cggcctcgac ggcgagggcg
     9721 acgagccgct cgtcgtcgcc gaagacggtc tcggtctcgg cgaagttggc gcggtacagc
     9781 acggcgagca gctcgtcctg gcggccgcgc gccttggcga ggtggagcag ccggtgcatg
     9841 tcgaaggtgc tgccgtggtc gcggccctcg gtgaggtacg gcaggccctc ggccgcggcg
     9901 ttctgcccga ggttccgctc ggcctcggcg gcctgcgcct cgctcatgcc gtacttcttg
     9961 gcgagcatcg gcaggaccag ctcggggtcg cccttggggc gggccgggtc cagctcgaag
    10021 gagcggtgca cgacctcgat ccggtcgcgg tgcgggaagg cggcgagcgc cttgtcgaac
    10081 cgcgcctttc ctacgtagca ccagggacag gcgatgtcgg accagatctc gacgcgcatg
    10141 gctgcggttc aactcctcgg cccggggacc gggcaggtcg ggggtgccgg gagcggtctc
    10201 ccggggcgtg cggacaccag ggtacggagg gtgcctccgc tctggtgcaa cgcggggccg
    10261 gaccggtgca ttccggaccg gcccgggtga gcccctgcgc cctcagaccc cctggtccgc
    10321 ccgcccgtcc acgtgccggg gcagccccag cgggttgccg tcccgcagct ccggcgggag
    10381 cagcgcctcg ggcgtggtc
//
