LOCUS       NZ_AP018365            25293 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  Streptomyces sp. SN-593 chromosome.
ACCESSION   NZ_AP018365
VERSION     NZ_AP018365.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. SN-593
  ORGANISM  Streptomyces sp. SN-593
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Panthee,S., Kito,N., Hayashi,T., Shimizu,T., Ishikawa,J.,
            Hamamoto,H., Osada,H. and Takahashi,S.
  TITLE     beta-carboline chemical signals induce reveromycin production
            through a LuxR family regulator in Streptomyces sp. SN-593
  JOURNAL   Sci Rep 10 (1), 10230 (2020)
   PUBMED   32576869
  REMARK    DOI:10.1038/s41598-020-66974-y Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Takahashi,S., Toyoda,A., Sekiyama,Y., Takagi,H., Nogawa,T.,
            Uramoto,M., Suzuki,R., Koshino,H., Kumano,T., Panthee,S., Dairi,T.,
            Ishikawa,J., Ikeda,H., Sakaki,Y. and Osada,H.
  TITLE     Reveromycin A biosynthesis uses RevG and RevJ for stereospecific
            spiroacetal formation
  JOURNAL   Nat Chem Biol 7 (7), 461-468 (2011)
   PUBMED   21642985
  REMARK    Publication Status: Online-Only
REFERENCE   3
  AUTHORS   Panthee,S., Takahashi,S., Takagi,H., Nogawa,T., Oowada,E.,
            Uramoto,M. and Osada,H.
  TITLE     Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds
            from Streptomyces reveromyceticus SN-593
  JOURNAL   J. Antibiot. 64, 509-513 (2011)
REFERENCE   4
  AUTHORS   Takahashi,S., Takagi,H., Toyoda,A., Uramoto,M., Nogawa,T., Ueki,M.,
            Sakaki,Y. and Osada,H.
  TITLE     Biochemical characterization of a novel indole prenyltransferase
            from Streptomyces sp. SN-593
  JOURNAL   J Bacteriol 192 (11), 2839-2851 (2010)
   PUBMED   20348259
REFERENCE   5  (bases 1 to 8833490)
  AUTHORS   Takahashi,S., Ueki,M., Toyoda,A., Ishikawa,J., Sakaki,Y. and
            Osada,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2017) Contact:Shunji Takahashi Chemical Biology
            Research Group, RIKEN Center for Sustainable Resource Science
            (CSRS); Hirosawa 2-1, Wako, Saitama 351-0198, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Phrap v. 0.990329
            Genome Coverage                   :: 16x
            Sequencing Technology             :: ABI 3730
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016756395.1-RS_2024_05_21
            Annotation Date                   :: 05/21/2024 03:58:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,420
            CDSs (total)                      :: 7,334
            Genes (coding)                    :: 7,181
            CDSs (with protein)               :: 7,181
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 153
            CDSs (without protein)            :: 153
            Pseudo Genes (ambiguous residues) :: 0 of 153
            Pseudo Genes (frameshifted)       :: 35 of 153
            Pseudo Genes (incomplete)         :: 136 of 153
            Pseudo Genes (internal stop)      :: 8 of 153
            Pseudo Genes (multiple problems)  :: 25 of 153
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:29:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4670935
            Orig. end                         :: 4696228
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP018365.1.
            This work was done in collaboration with Shunji Takahashi, Masashi
            Ueki, Atsushi Toyoda, Yoshiyuki Sakaki and Hiroyuki Osada (RIKEN)
            and Jun Ishikawa (National Institute of Infectious Diseases).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25293
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="22"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25293
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25293
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15293](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15293)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    343..356
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            complement(803..2014)
                     /locus_tag="RVR_RS19585"
                     /old_locus_tag="RVR_5498"
     CDS             complement(803..2014)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990583.1"
                     /locus_tag="RVR_RS19585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5498"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_346731462.1"
                     /transl_table=11
                     /translation="MAGKESDQRDTGDMGSVIAVPGPGANVSRLRKERGWGQARLAAAA
                     GVSTSQLGKIERGERTLTQGVAASLARAMSLSLEEVLGTTPVPLDAAGSVRALNSAVRR
                     FDLPREPEMTEDEIAAALASMGEARNSADLDQVLVDLPRLVAGAQDHAHAMGTPEACAL
                     VVEAYSTVYWLAARHRWMTLADLAVTKQKLAAQQSDPVTAALAARDEAGVYLNHGEFDD
                     GLAVVDRAITQAEGSTTGPGRSYALGILHLRGLTLAGRLQDKRTADQHITRAWAMAEGF
                     TEDVERCGIQFGPENTAVHVIATSGDLRRHADAISTMEDLVRDGTSLPATRTSPLHMNT
                     ARSRLALGDREGALADLEQAWALAPQMAKVHPTSQEVLRVLTSAHKRSNPRIVKLAKKA
                     HIQF"
     misc_feature    complement(2714..2727)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.7"
                     /tool="antismash"
     gene            3039..3542
                     /locus_tag="RVR_RS19595"
                     /old_locus_tag="RVR_5500"
     CDS             3039..3542
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS19595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_5500"
                     /product="hypothetical protein"
                     /protein_id="WP_202235083.1"
                     /transl_table=11
                     /translation="MPSRHPRGFACGRRIFMPPDLVTAVLGMANSVPPAWDGLVYSPDD
                     VGTLLVCTLQGHRGPVHHGVVLNLRGPGTGTVWAAWRDGVEPCLALLLPDCPVATEDGG
                     EACSEFAGHPGAHSWELADPVLPPALVALFGPLLAEQDRPPDGRVLDAATRFHRPTTNR
                     NPAR"
     gene            3539..4060
                     /locus_tag="RVR_RS19600"
                     /old_locus_tag="RVR_5501"
     CDS             3539..4060
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS19600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_5501"
                     /product="hypothetical protein"
                     /protein_id="WP_202235084.1"
                     /transl_table=11
                     /translation="MNPAVPSPTALPAPESDGTARSLRQWLLTTTTGEQVSGHLPPWAT
                     EDPSEQEVPAEELAARLADVCHYREFPGQVLRAYSPGNSSDAPEELEVMSSSITCAPYA
                     PAPELALPVVTVRVAGEYWMTDLDPTGVADLVAGLRAVADRLDSVVIPQLNTIRTEWTA
                     HHTSGTGARL"
     misc_feature    3569..3571
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4057..4938
                     /locus_tag="RVR_RS19605"
                     /old_locus_tag="RVR_5502"
     CDS             4057..4938
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.3"
                     /locus_tag="RVR_RS19605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5502"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_202235085.1"
                     /transl_table=11
                     /translation="MTTDTTPVVDPVTTSADRLAAFRVAIASGQVSARALYAHHLAFLR
                     AKAGLSLVELADRCHYEQSYLHRLETGGRLGNMLVAETLDRFYGTGELLAGLWLLAKRE
                     AKRAAGGLTALEETATSIRAYALTTVPALLQTPAYAEEQLATTHPQSPEVLAAQLNVLR
                     ERQARLTETTPHPVRYRAVLDELVLHRGARNQATWDGQLDHLIATAHEPAVTLQLLPLH
                     SGPHDLRGPLQLLSFRVGTTLAYVHGTLTDQITDDPDDIEELSQQYDQVRDLALTPAQT
                     IEHLHTLRTSTR"
     gene            4974..5543
                     /locus_tag="RVR_RS19610"
                     /old_locus_tag="RVR_5503"
     CDS             4974..5543
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS19610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_5503"
                     /product="hypothetical protein"
                     /protein_id="WP_202235086.1"
                     /transl_table=11
                     /translation="MSPTTLLTNPTTTRPPEPDSTMTPPPAEHAPCTWTVTTVEGITLT
                     GTQPDWSMDNPSDTGMTLAQAIDHLRGYAHYTMLPVDPVLPPAILDTDINGTRVRDSTS
                     MMFAAQIACHPYAPHPHERVPTASLTIVEEWDFEGLTPTDLTRFATQIRTQADYFENTV
                     LPELITARNDWTTHHSPIPDPDHPAR"
     gene            5604..5912
                     /locus_tag="RVR_RS19615"
                     /old_locus_tag="RVR_5505"
     CDS             5604..5912
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013677.4"
                     /locus_tag="RVR_RS19615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5505"
                     /product="transposase"
                     /protein_id="WP_202235087.1"
                     /transl_table=11
                     /translation="MESMGKKPRRARRSFTPEFKAEIVELCRRGDRSIGQVATDFDLVE
                     TRVRDWVRQAEVDAGERDGLTGNERDELAALRRENRRLREDVEVLKRATAFFAKETR"
     gene            5909..6778
                     /locus_tag="RVR_RS19620"
                     /old_locus_tag="RVR_5506"
     CDS             5909..6778
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF033516.0"
                     /locus_tag="RVR_RS19620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5506"
                     /product="IS3 family transposase"
                     /protein_id="WP_202235088.1"
                     /transl_table=11
                     /translation="MNVHSFIEAEEQAGHSVTRACELLKVSRAAYYARRSGPSARTCDD
                     AELTEKIRAVHARSRGTYGSPRVKAALNRDGTVCGRRRVARLMQQADLTGITRRRRQRT
                     TIPDPKAAIRPDLVLRDFQPNPAGADTLWCGDITYIPTDEGWLYLATVIDIATRRVVGW
                     ATADHLRTSLVADALTTACRTRRPTQHVVFHSDRGCQYTSRELASLAGQLNVRLSVGRT
                     GQCWDNALAESFFSTLKNELLSRQSWPTRAAAHTAIFEWIESWYNLYRLHSSLGYRSPA
                     DYETTLAA"
     repeat_region   7082..9921
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=4678017..4678045
                     /rpt_unit_seq="ctgctccccgcgcccgcggggatggaccc"
     gene            complement(10001..11002)
                     /locus_tag="RVR_RS19625"
                     /old_locus_tag="RVR_5507"
     CDS             complement(10001..11002)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955820.1"
                     /locus_tag="RVR_RS19625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5507"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_202235089.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.1e-28, bitscore:
                     97.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPADQLSAAATSVIEGAVREVLAGNAVDEVALHHSLTPDHLCDAV
                     SLFAAAGREALVQHAAEGKWWQINLAFTEPSTGDRAFTTHLLPLLRATDIDSWWFMRKQ
                     PGYRVRVLASPSAKAKAKAALNQLVADGHIRECQTVVYEPETAAFGGETSMQIAHHLFA
                     TDSLQIQQFGAQDTRLPTGLRELSVLLCTTMMRSAGLEWYETGDVWNRVITAEHRADFT
                     GLAPDALTNRVQQIRTLLLADTSALFARGGPLGQFEEWATAFQNAGRSLREAADHGTLG
                     RGLRHILSLHVIFHWNRLGLSLRAQSHLASAARSAIFERNQANALRADDRTE"
     gene            complement(10984..12222)
                     /locus_tag="RVR_RS19630"
                     /old_locus_tag="RVR_5508"
     CDS             complement(10984..12222)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490581.1"
                     /locus_tag="RVR_RS19630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5508"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_202235090.1"
                     /sec_met_domain="LANC_like (E-value: 9.8e-41, bitscore:
                     138.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPASTTVSAADLLQQFTALVNEARPQPPKPPDAGQSLAVGAAG
                     TALLFVERAWHDQPWRPAHRLIAEATAGEVNAGDTGGLFLGATAVAFLLSATPHDREHL
                     YADARATLHRQVTALAHRRADAADQRLRAGEPLAFADYDLFYGLTGIGAYLLRTDPGSS
                     ALGRVLAYLVALTRPRTLNGSDLPGWWVHHDPLRAHSDHFPGGHANLGTAHGITGPLLL
                     LAKALRTGIKVEGHRTAIRIICDFLDTWRQDAPEGPWWPTYLSYEDVQRRRPGQDRPGR
                     PSWCYGTTGIARAGQLAGISLGDTTRQALYEDALYRALTAPAQLRVVVDAGLCHGWAGI
                     YQTVVRATDDSNDPRLPGLRHQLAVALITHARPNTAKGRGLLEGAAGTALALSTLAHSK
                     PPDNGWDACLLIN"
     gene            complement(12219..15293)
                     /locus_tag="RVR_RS19635"
                     /old_locus_tag="RVR_5510"
     CDS             complement(12219..15293)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746441.1"
                     /locus_tag="RVR_RS19635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5510"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_202235091.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1e-182, bitscore:
                     607.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.9e-17,
                     bitscore: 61.1, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSRASTYTWQGLALLRASTLPGAADVPRTLDLDDPTSTRLWLER
                     VWGRPGVHHALSLASPGLSNAVRTLIGDPTRSARDVRRAASSTVAYLLRWQHRSTPLGL
                     FSGVAPATVGPQVGAQWRDKHPMTVRTDGEWIAAVIKRLHRSPGLLQRLPLLANDVAHV
                     RGGRLVAPGPPSLAFDHTLGPIEISIRNRPPVAATMEAARTPIPYRDLHARLRTQFPRA
                     PSEQVHTLLTELVDQQFLLTSLPAPMTTTDALDHLCRALDDVHADEVPDVQETVQALRA
                     IREDLSGRQPTLTTDGLDVIASRMTAVTDVTDRPLHVDTALDCDVQIPPAVIDEVTAAV
                     TAAYRTTPQPYGRWAWLDYHNRFRDRYGPGAVVPVPDLVADSGLGLPTGYDGVTRESVP
                     KAHTARDDVLLALVQQALMNGRGELLLTKETVATLEAAAGSDERILAPRVEAGFEIHAP
                     SGAALARGDFRAVLTAMPRPASSLAGRFAHALPSDARKALAATYAGSPEALDAQLVFTP
                     RRARNTNVARTPLLLPRVLEISGWKHTDGGSGVPGESVLPLTEIGVTADARTLRLVHLP
                     TGRTIHLQVVHALEAGLQTPVLARFLAEVSTARSAVYGLFDFGAASRLPYLPRVRHGRT
                     VLRPARWLLKATDLPGRRATGAQWDAAFDSWRARMAVPDQVAVVDYDQVLPVDLTHPVH
                     RQLVRTQIGDAHELEMRETSCGDAAHGWTGRATEFWISLALPQAPAPRLPAPVRTVAPS
                     DRQLPGGNALHARIHADPLRFADILTRHLSRLLTTLDDRAPTWWFSRRRELSHADADQQ
                     LTLTLHPRPGTHAEVLEVFNAWAAELYSLGLSSGFALVPYQPQTGRWGYDEAMDAAHRL
                     FAEDSTATLAQLTFADRNRLSPQALAAASAFHLASRLAPCPDDGFQRLVADLPRSTGPL
                     DRKVRDQALHLADSAAGPLADLPGGERVVAAWQSRADAADAYRHALAGQRDPFTAARSL
                     IHQHHLRAVNTDPMSEAVTVRLVRAAALRNLRTTR"
     aSDomain        complement(14556..14825)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_RVR_RS19635_Lanthipeptide_LanB_RRE.1"
                     /evalue="1.90E-19"
                     /identifier="RREFam001.1"
                     /label="RVR_RS19635"
                     /locus_tag="RVR_RS19635"
                     /protein_end="246"
                     /protein_start="156"
                     /score="61.1"
                     /tool="antismash"
                     /translation="ANDVAHVRGGRLVAPGPPSLAFDHTLGPIEISIRNRPPVAATMEA
                     ARTPIPYRDLHARLRTQFPRAPSEQVHTLLTELVDQQFLLTSLPA"
     gene            complement(15375..15569)
                     /locus_tag="RVR_RS19640"
     CDS             complement(15375..15569)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380187.1"
                     /locus_tag="RVR_RS19640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_202235092.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.6e-13, bitscore:
                     49.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTATLLPTAPPLLDEDDDFAPLDVTVVVSTKLNGALMCDTGDGC
                     GSTCSNGASACDSAAGDPA"
     gene            complement(15667..16905)
                     /gene="fxlM"
                     /locus_tag="RVR_RS19645"
                     /old_locus_tag="RVR_5514"
     CDS             complement(15667..16905)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955816.1"
                     /locus_tag="RVR_RS19645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5514"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_202235093.1"
                     /sec_met_domain="PCMT (E-value: 2.4e-36, bitscore: 124.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTSTTTEPPEATCLRNGCVDQLKADGVIVSPFVEKVMRQVPRHA
                     FAPDTSLDDAYSPYAAVITKTGENGVQLSSVSAPQIQAMMMEQAGIKAGDRVLEIGSGG
                     LNAAYLAELVGQEGNVTSVDIDPEVTGRARRLLDAHGYTRVRVVTADASQPIPGLGEVD
                     VIMVTVGAWDIPPAWVDQLSPNGRLVVPLRMRGLTRSVAFQRVTDSHGGHLESTSALVC
                     GFVAMQGSDQHDETQVLVNGTPEIALRFDDGAPADPHLLDNAVRTPRVEQWTGVTVALG
                     EPFSGLQMHLAIDLPGFCVMSVDPQLDTGIVSPRHKGFSAAAVDGGTFAYVTTRRTPDD
                     ERAEFGVHALGPDASTFANTVAGSVRAWDREHRGGSDPLIRVHPAGTPDEAVPGDRVIE
                     KRHSRISLSWPPA"
     gene            complement(16963..17517)
                     /locus_tag="RVR_RS19650"
                     /old_locus_tag="RVR_5515"
     CDS             complement(16963..17517)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS19650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_5515"
                     /product="hypothetical protein"
                     /protein_id="WP_202235094.1"
                     /transl_table=11
                     /translation="MAGPLPSWADCDPSEDGVPPTELPVRLSDITHHAEFPGQTVTVYS
                     PSHASGRPCDIEILHGSIDCIPFAEQPACRVPVVNLRLTDDCWITDRTPDGLAALSAQL
                     RSQADRLDREIRPALITARSDWTEWTDQRPDRPPPHPRWGLSPPPSSSGDLGNALADLR
                     NYRDANRRRFSESAHAGRAGR"
     gene            complement(17734..18333)
                     /locus_tag="RVR_RS37755"
     CDS             complement(17734..18333)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS37755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_237404859.1"
                     /transl_table=11
                     /translation="MGVRLPRRSPREDRLGAAAAAAAAPAPAIDGGVPTGERPGALSAS
                     ATFRTAHEAHTRTPRTTTRTVCPPRKGYSNDAATIARTHTLLALSQADRYLADLPVDDT
                     DLDTLEAVLSEPEFGVLEGGRVRELAPGLLGTLRRLASRVPPSAGFVPVVQSVMDDVRH
                     DDHVPPDVACLRRWALAVQGLLEQAAARYEATARPP"
     misc_feature    complement(18208..18210)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18319..18321)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18732..18750)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 24.35"
                     /tool="antismash"
     gene            19034..19333
                     /locus_tag="RVR_RS19660"
                     /old_locus_tag="RVR_5517"
     CDS             19034..19333
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013677.4"
                     /locus_tag="RVR_RS19660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5517"
                     /product="transposase"
                     /protein_id="WP_202233660.1"
                     /transl_table=11
                     /translation="MSNKAGKRYSKEFKRDAVALARSSSKTVTEVARDLGVSPEGLRSW
                     VKQDQIDRGEGGPGELTGAEHEELRRLRRQNIEQQRTIEVLKKATAFFARESER"
     gene            19330..20211
                     /locus_tag="RVR_RS19665"
                     /old_locus_tag="RVR_5518"
     CDS             19330..20211
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF033516.0"
                     /locus_tag="RVR_RS19665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5518"
                     /product="IS3 family transposase"
                     /protein_id="WP_202233659.1"
                     /transl_table=11
                     /translation="MSEVYRFIAAEKATYPVTLLCRILGVHRSSFYAWAEGQVARGARL
                     RADDALAHEITVIHLASRGAYGVPRVHAELRRLGHAVNHKRVERLMRERRIAGITRRHR
                     RSLTRPDKQARPAPDLIGRDFTADRPGTRLVGDITYLPTEQGWLYLACWLDLATREVVG
                     WSMADHHRADLVVDALHMAHDRGRLEPGCIAHSDRGSEYTSAQFRTAVTELDMKVSTGR
                     TGSCYDNAAAESFWAVLKAEIGTRTWPDRATARAAVFSYIETFYNRRRLRKHPDWGYLT
                     PQETRQRHTLAA"
     gene            20273..21445
                     /locus_tag="RVR_RS19670"
                     /old_locus_tag="RVR_5519"
     CDS             20273..21445
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715831.1"
                     /locus_tag="RVR_RS19670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5519"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_237404860.1"
                     /transl_table=11
                     /translation="MNDVILKVTGRPGDVSDRTVRNLLSGSTVRPIARTCAALEAVFSC
                     RVEDLGFKPPRSAAPQEVPVRRRTFMASAAGTATAGLAPALAGPNRVGSSDVARLETKF
                     AAIIAEDHKYGGLVSTETRASAMAGEALSLLQRGSTSQLVRNKLYASAAGFTSSAMWAA
                     IDGRRFNEAQRYFDRASTLAAMSGDATIMFRIWSHAGTLYRHLGRPIDALAANDVARGL
                     PVARRDPMFASLGQSRHAAILGLTRDSVAVERSIAQAQAAYSRADPDAQRPAWITAFYD
                     QAEIESLALTAYLALGDFERAEAHAHRGIARLRPHMRRSRAIATARLAHAQLGQGDVDA
                     AVATAVGTQSTHPRVTRMLEEFGNKLSIQAPRSDAAKTWNDHASTRRDAS"
     misc_feature    20420..20422
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            21442..21978
                     /locus_tag="RVR_RS19675"
                     /old_locus_tag="RVR_5520"
     CDS             21442..21978
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151264.1"
                     /locus_tag="RVR_RS19675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_5520"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_202235096.1"
                     /transl_table=11
                     /translation="MTSTAIDLRHFRDIEPAWDTLIDLYAEVRADKLHDPHYSVERYAE
                     RLARHAHEPGWEAVIGYDGDEAVGYAYANTVEQDDRYWKRITTPLADSVTAVPTLALKE
                     IGVRVPWRKTGVSKAIHDSLLAARSETQATLMVNPLAGDGKVHNLYVSWGYGDLGESQP
                     SPDSPVLVAMVRALP"
     misc_feature    complement(22200..22213)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.73"
                     /tool="antismash"
     repeat_region   22360..23669
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=4693295..4693323
                     /rpt_unit_seq="ctgctccccgcgcccgcggggatggaccc"
     misc_feature    22684..22698
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.5"
                     /tool="antismash"
     misc_feature    22989..23003
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.5"
                     /tool="antismash"
     misc_feature    23175..23188
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    complement(24224..24233)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 tcgggccaga tgacggagta gggcacgccg gtgcgtttcg cgtaggcgac gacgtcggcg
       61 gtgcccccgt agccgcgggc gggttggccg tcccagacgg ccaggaggag gtcgacgacg
      121 ccgacgagga tttcgctgcc ggcctggtgg gcttcggagg tggactcctt gagcccggtg
      181 acgtggactt cgcaggctcg ccggagaagc gcgtcgtagg tggagtgatg ggactcgggg
      241 aggttctcgc ggtactcctc ggccgggatg acgacttcga tctgcccgcc gtggtcgagg
      301 accgcttccg cgaaccacgc gtcggggccg tcggcgatgc agctgacccc gatcaggtcg
      361 gtcggcgggt actgctcgat caccgtggtg agtgcggccc ggacgagccg cgccgcatgg
      421 tccggcagcc cgcggtggcc ggtgatgccc aatcgcacgt taacctgccc ttacgttcgt
      481 cgctgatcag aggtagacgc cgtggagtcg ttcgtcgaag tccctgacga ccttcggcgg
      541 ggtggacgag gtgtgggagc ggcgtacggc tcgggccctc tccacgatcc gaccggaacg
      601 gtagcgcacg cctgtctcca acgcccgggt tgcgagggcg aatgcgccag tggtccggcc
      661 ggacgccaaa cgtgcttgtg cgaggtcgag ttggaggagt gcgcgctgct tcgcgtgggt
      721 ggaggcgagt gcttcttcgg cgtcgtctga gccgggactg cacgtcgagc agtccttcgg
      781 acggctttgc tgttgtgcgg gatcagaact ggatgtgtgc cttcttcgcc agtttcacga
      841 tcctcgggtt gctccgcttg tgggcggagg taaggacgcg gaggacttcc tgggaggtgg
      901 ggtggacctt cgccatctgg ggtgcgaggg cccaagcctg ctccaggtct gccagcgcgc
      961 cctcgcggtc gcccagggcg agcctggagc gggcggtgtt catgtggagg gggctagtcc
     1021 gggtggccgg gagggaggtc ccgtcgcgta cgaggtcttc catggtgctg atggcgtccg
     1081 cgtgacgtcg taggtcgccg ctggtggcga tcacgtggac ggcggtgttc tccggcccga
     1141 actggatgcc gcagcgctcg acgtcctcgg tgaagccctc cgccatggcc caggcgcggg
     1201 tgatgtgctg gtcggcggtc ctcttgtcct ggaggcggcc ggccagcgtc agtccgcgca
     1261 ggtggaggat tcccagggcg taggagcggc ccggccccgt agtgctcccc tccgcttggg
     1321 tgatcgcgcg gtccacgacc gccagcccgt cgtcgaactc gccgtggttc aggtagacgc
     1381 cggcttcgtc ccgggcagcc aaagccgcgg tgaccgggtc ggactgctgc gccgccagct
     1441 tctgcttcgt gacagcgaga tcggccagcg tcatccagcg atgccgggcc gccagccagt
     1501 acacggtgga gtacgcctcc acgaccaagg cacaagcttc cggcgtgccc atcgcatgcg
     1561 cgtggtcctg cgccccggcg accagcctcg ggagatcgac gaggacttgg tccaggtcgg
     1621 cgctgttgcg cgcttcgccc atggaggcca gggccgccgc gatctcgtct tcggtcatct
     1681 cgggctcgcg gggcaggtcg aacctgcgca ccgcgctgtt gagggccctg acggagccgg
     1741 cggcgtcgag ggggaccggc gtcgtgccga gtacctcttc gagtgacagg ctcatcgcgc
     1801 gtgcgaggga ggccgcgacg ccttgggtca gggtgcgctc tccgcgctcg atcttgccga
     1861 gctgggacgt ggacacccct gctgcggctg ccagccgtgc ctgcccccaa ccccgttcct
     1921 tccggagtcg ggacacgttc gcgccgggcc cgggaactgc gatgactgat cccatatcgc
     1981 ctgtgtctct ctgatcgctt tccttccctg ccatggtcac ccaccatcct taccccgctg
     2041 tgggcttgtg cacttcttgt gcactttcgc atgtcgtttc cgtcgttgac tgattacgga
     2101 aagcggcgtt gtcccggtcg atccgtcggt cgggggcgcc cgagacgtcc gcgaaaggtg
     2161 tgactgtggc ccccagcttg cgctttcaca gtgtgctgga cctggcgtgc gaacagtcgg
     2221 cggttcgctg gtccagggaa catgccaggg ctgtcttacg ggagtgggac gtgcgggggg
     2281 acgctgcgta cgacgcactc accatcgtcg ccgaactggc ttccaacgcc gtacgtcacg
     2341 cgggcctcac cacgcggtcg ccctccgtcg gctgcggaca accgcggcag ccgcggtgcg
     2401 aattgaccct gtgggtcgtc aacagccgtt tgtacatctc catgtacgac gagagcgcgc
     2461 accggcccgt cctgcgtccg ctgtccgccg actccgagac cggcaggggc ctgcacatga
     2521 tcaacggtct cagcaacggc gcgtggggat tccaccccgc cacgcgcggt cctgggaagg
     2581 tcgtttgggc cgctctgcgt ctcgaagccg gggtgcccac gactgctcat gccgccgggc
     2641 ggaccggtac cggtgaacgg gggaagtggg gcgccggctt tcgcgacgac cgcgccgcgc
     2701 atcggttccg cctgaaccgg acgtttccca gatcgctgta caagctgcga cggctcacgt
     2761 ggcgggtgcc gctgcatcga tcccccacag cgcacgacgc acacccgccg tcgctccccc
     2821 tccgctccag cggcctaccc gcggatcgcc caagtccgct ggacgaactc ccgtccccgt
     2881 gagcgtggac ctatcccgct ctggtcacgc cgagtcaagc aggcatccat gcccccaccg
     2941 ttccccgcgg gcgtgacgga ctcacggcac cagcccgtgg cctgaacagg ccccacccaa
     3001 cccctgtatg cagcgatgcg acgaaggagt cgattcggat gcccagccgt cacccgcgcg
     3061 gcttcgcctg cggccggcgg atcttcatgc cgcccgacct cgtcaccgcg gtcctgggca
     3121 tggccaacag cgtgcctccg gcctgggacg gcttggtgta cagccccgac gacgttggca
     3181 cgctgctggt ctgcacgctc cagggccacc gcgggccggt ccaccacggt gtggtgctga
     3241 atctgcgcgg tccgggcacc ggcaccgtct gggcggcctg gcgtgacggc gtcgagcctt
     3301 gcctcgccct cctgcttccc gactgcccgg tcgccacgga ggacggtggt gaggcgtgca
     3361 gcgagttcgc cgggcatccc ggtgcccata gctgggagtt ggccgacccg gtcctgccgc
     3421 ccgctctcgt cgcgctcttc ggtccgctcc ttgccgagca ggaccggccg cccgacggac
     3481 gcgtgctcga cgccgccacc cgattccacc gccccaccac gaacaggaac cccgcacgat
     3541 gaaccccgcg gtcccttcgc ccactgcctt acctgccccc gagtccgacg gcactgcccg
     3601 ctcgttgcgg cagtggctgc tcaccacgac caccggagag caggtctccg ggcacctgcc
     3661 gccctgggcc accgaggacc ccagcgaaca ggaggtgcca gcggaggagt tggccgcgcg
     3721 gcttgcggac gtctgccact acagggagtt ccccgggcag gtcctgcgcg cgtactcgcc
     3781 cggcaactcc agcgacgccc ccgaggagtt ggaggtcatg tcctccagca tcacctgcgc
     3841 gccctacgcc ccggctcccg aactggccct cccggttgtc acggtacggg tcgccgggga
     3901 gtactggatg accgacctcg acccgacggg agtggcggac ctggtcgcgg gcctgcgcgc
     3961 ggtggccgac cgactcgaca gcgtcgtcat cccccagctc aacacgatcc gcaccgagtg
     4021 gaccgcccac cacacctccg gtacgggggc ccgcctgtga ctaccgacac cacgcccgtc
     4081 gtggaccccg tgacgaccag cgctgatcgg ctcgcggcct tccgggttgc gatcgcctcc
     4141 gggcaggtga gcgcccgtgc cctgtacgcc caccacctcg cgttcctgcg cgcgaaggcc
     4201 ggcctctcct tggtcgagct ggccgaccgg tgccactacg agcagtccta tctccaccgc
     4261 ctggagaccg gtgggcggct gggcaacatg ctcgtcgccg agaccttgga ccgcttctac
     4321 ggtaccgggg aactgctcgc gggactgtgg ttgctggcca agcgcgaagc gaaacgcgcg
     4381 gccgggggac tcaccgccct ggaagagacc gcgaccagca tccgcgcata cgccctcacc
     4441 accgtccccg ccctgctcca aacccccgcg tacgccgagg agcaactcgc caccacccac
     4501 ccgcagtcac cggaggtgtt ggccgcgcag ctcaacgtgc tccgcgaacg ccaagcccgc
     4561 ctcaccgaga ccacacccca tccggtccgc taccgggccg tcctcgacga actcgtcctc
     4621 caccgcggcg cccgcaacca ggccacctgg gacggccaac tcgaccacct catcgccacg
     4681 gcccacgagc ccgcggtcac cctccaactc ctccccctgc actccggccc ccacgaccta
     4741 cgcggccccc tccagctgct gtccttccgc gtcggcacca ccctcgcgta cgtgcacggc
     4801 accctcaccg accagatcac cgacgacccc gacgacatcg aagagctcag ccagcagtac
     4861 gaccaggtgc gcgacctcgc cctcaccccc gcccagacca tcgaacacct ccacaccctg
     4921 cgcaccagca cccgctgacc aaccaacgcc accgcgccca ggagccgccg cccatgagcc
     4981 ccacgaccct gctcaccaac cccaccacga cacggccccc cgaaccggac tcgaccatga
     5041 cgccgccacc ggcggaacac gcgccgtgca cctggacggt caccacggtt gagggcatca
     5101 ccctgaccgg cacgcagccc gactggtcca tggacaaccc cagcgacacc ggcatgacgc
     5161 tcgcccaggc catcgaccac ctgcgcggct acgcccacta cacgatgctg cccgtcgacc
     5221 cggtccttcc gcccgccatc ctcgacaccg acatcaacgg cacccgcgtc cgcgactcga
     5281 ccagcatgat gttcgctgct cagatcgcct gccaccccta cgccccacac ccgcacgaac
     5341 gggtccccac cgcgagcctc acgatcgtcg aggagtggga cttcgagggc ctcaccccca
     5401 ccgacctcac ccgcttcgcc acccagatcc gcacccaggc cgactacttc gagaacaccg
     5461 tcctccccga actcatcacc gcccgcaacg actggaccac ccaccattcg cctatacccg
     5521 atccggacca ccccgcaagg tgagcttgct ccggtttggc ggacattcga gatcaggggt
     5581 tcgtccccgg gaggatgtcc atcatggaga gcatggggaa gaagcctcgt cgcgctcgcc
     5641 gctcgttcac gccggagttc aaggccgaga tcgttgagct gtgtcgccgt ggcgaccgct
     5701 cgatcggcca ggtcgccacg gacttcgacc tggtcgagac ccgggtgcgt gactgggtcc
     5761 ggcaagcaga agtcgatgcc ggcgagcggg atggcttgac cggcaacgaa cgtgacgagt
     5821 tggccgcgtt gcggcgggag aaccgccgtc tgcgcgagga cgtggaggtc ctcaagcgag
     5881 ccacggcttt cttcgcgaag gagacccggt gaacgtccac tcgttcatcg aggcggagga
     5941 gcaggcaggc cacagtgtca cacgcgcatg tgagctgctg aaggtctccc gtgccgccta
     6001 ctacgcccgc cgttcaggcc ccagcgcccg cacctgtgac gatgctgagc tgaccgagaa
     6061 gatccgtgcg gtccacgctc gctcccgagg cacctacggc tccccgcgcg tgaaggccgc
     6121 cctcaaccgc gatggcactg tctgcgggcg tcggcgggtc gccagactga tgcagcaggc
     6181 ggatctgacc gggatcacac gccgacgccg ccagcgcacc accatcccgg accccaaggc
     6241 ggccatccgc ccagacctgg tactacgaga cttccagccg aaccctgccg gcgctgacac
     6301 gctctggtgc ggcgacatca cctacatccc caccgacgag ggctggctct acctggccac
     6361 cgtcatcgac atcgccaccc gccgcgtcgt cggctgggcc accgccgacc acctgcgcac
     6421 gagcctggtc gccgacgccc tcaccaccgc ctgccgcacc cgccgaccga cccagcacgt
     6481 ggtcttccac tccgaccgcg gctgtcaata caccagccgc gaactcgcct cactcgcagg
     6541 acagttgaac gtccgcctgt ccgtagggcg caccggacag tgctgggaca acgccctggc
     6601 ggagtcgttc ttctcgacgt tgaagaacga actgctcagc cggcaatcct ggcccaccag
     6661 agcagccgcc cacactgcga tcttcgaatg gatcgagagc tggtacaact tgtaccgtct
     6721 gcacagcagc ctcggatacc gcagtcccgc cgactacgag accactctcg cagcctgacc
     6781 agcgcacaga agctgtctgt caaagcggag caagcccagg gccaggtctg gagttcgtcg
     6841 ggtcgcgtcc ctggaagtgg ttcggcgcga tgcttacggg ttgcagtcgt ggagccgctg
     6901 agtcgagccg gcacgtttgc tgctttgcgt ggtggccgag agcggtaaga cttcgcgcgg
     6961 ccgtacgctg tgcggtgggg agtcgacggc acctctcgtc cattcgatgc cctaaatgtc
     7021 gctttctctg aagttggttc agggcagctt ggccctctag gaaacccgca ggtcagtcag
     7081 actgctcccc gcgcccgcgg ggatggaccc cagaagtttc acatcggatt cgtcgctccg
     7141 gactgctccc cgcgcccgcg gggatggacc cagtatgagg gacgccggag aggaacccgg
     7201 aggctgctcc ccgcgcccgc ggggatggac ccagcccccg gcggcgccgc cgctcagccc
     7261 ccgcctgctc cccgcgcccg cggggatgga ccccaccccc cacgggccaa cttcgttcag
     7321 gagctctgct ccccgcgccc gcggggatgg accctcccga ccaccggtcg acggacccgg
     7381 ccgtgtctgc tccccgcgcc cgcggggatg gaccctgggc cacggcggac cgtgcggtcc
     7441 gccgtggact gctccccgcg cccgcgggga tggacccgac atcgtgatcc gcggaacgtt
     7501 ccaggggttg ctgctccccg cgcccgcggg gatggaccct ggatcatgtt cacttgcctt
     7561 tcggagggga gctgctcccc gcgcccgcgg ggatggaccc gcttcccgga acgccggaag
     7621 cggcgtccgg ggctgctccc cgcgcccgcg gggatggacc cggggccggg tgtctcacca
     7681 cccggccccg ccactgctcc ccgcgcccgc ggggatggac cccggccgcg ccgatgatca
     7741 gggtggcggt gtgcctgctc cccgcgcccg cggggatgga ccctccccgc cgccgtcggc
     7801 gcccacgccc tgtggctgct ccccgcgccc gcggggatgg acccgccatg taccgggcgg
     7861 gcgcgcagca cgacatctgc tccccgcgcc cgcggggatg gacccggcag caactcccac
     7921 accgtggtca ttggtgactg ctccccgcgc ccgcggggat ggaccctcct cgaccggctc
     7981 gcgggagagg ggcgcgtgct gctccccgcc cccgcgggga tggacccgcg aggcccaggc
     8041 caaggccgcg gcgtcccagc tgctccccgc gcccgcgggg atggacccga gatgatccgc
     8101 ggcacgacga gcatgccgag ctgctccccg cgcccgcggg gatggacccc acgagaccgt
     8161 tcggaaggcc gtcgttcgca tctgctcccc gcgcccgcgg ggatggaccc acccgggcct
     8221 cggcggtcag gtgctgctcg gtctgctccc cgcgcccgcg gggatggacc ccgggtccgc
     8281 gacaagatca cacgggtgat ccgctgctcc ccgcgccagc ggggatggac cctacctccg
     8341 cggcggaacc ggccaggtcc gggactgctc cccgcgcccg cggggatgga cccttgcggc
     8401 ccatgggtca gcccttctgg gcggcctgct ccccgcgccc gcggggatgg acccccgtcg
     8461 agccgcgagg acgactggct ggacgcctgc tccccgcgcc cgcggggatg gacccgacgc
     8521 ccccgtgacg ctcgctgtgc tcgaggactg ctccccgcgc ccgcggggat ggacccgcta
     8581 ccgtacgtgc ggtattccgg ataaccctct gctccccgcg cccgcgggga tggaccttgc
     8641 taccccagcg atcacagcca agggcttccc tgctccccgc gcccgcgggg atggacccct
     8701 cgtggccaac cccagtttcg aggccgacgg ctgctccccg cgcccgcggg gatggacccc
     8761 acacacgctt gacgatccac accaccaggc cctgctcccc gcgcccgcgg ggatggaccc
     8821 accagcgccg tgaggatcag acgtcggtcc gactgctccc cgcgcccgcg gggatggacc
     8881 ccagcgcggg ccgatggtga tcgagcggga ccggcctgct ccccgcgccc gcggggatgg
     8941 acccgccacc aggaccaccc cgcccgccca agccggctgc tccccgcgcc cgcggggatg
     9001 gacccaggtc ggtgaccggc cagttccaca ccggggcctg ctccccgcgc ccgcggggat
     9061 ggacccgggt actcgggcga ggtgatgtgg aacatcggct gctccccgcg cccgcgggga
     9121 tggacccgcg tggagggtgc cgtccgccgt gccggagacc tgctccccgc gcccgcgggg
     9181 atggacccag gcgctggccg tcgtcgtcga ccagcgacat ctgctccccg cgcccgcggg
     9241 gatggacccc ccaccccgtg gcactaccgg cagatcgacg tctgctcccc gcgcccgcag
     9301 ggatggaccc cacgtcacga cgcacccccg gccagcgtca gcctgctccc cgcgcccgcg
     9361 gggatggacc cgtcatcgca gtcgccgacg gcgtcctcgt tccctgctcc ccgcgcccgc
     9421 ggggatggac ccggggcgta ctgcccgtcc agcgcctcga cgtcctgctc cccgcgcccg
     9481 cggggatgga cccagggctg cggccagtcg ggacttgccg gacccctgct ccccgcgccc
     9541 gcggggatgg acccacgctg tccccgccac gcggggtgtc gcccccactg ctccccgcgc
     9601 ccgcggggat ggacccagta cccagcccga gacgatcggc ggtcaggtct gctccccgcg
     9661 cccgcgggaa tggacccgag gagatgacga cctcgtggga gcggcgcccc tgctccccgc
     9721 gcccgcgggg atggacccgc gtgcgtcacg agcccgtgcc ccaccaccag ctgctccccg
     9781 cgcccgcggg gatggacccg cgaggccgga gcaggcgacg atggcggcgc cccgctcctc
     9841 gcgcctgcgg ggatggaccc tacgcgatga agtacttggg cccgacggcc cactgctccc
     9901 tgcacccgcg gggatggatt cgcgtgggca ggctgacatc gatgcaggct gtgagtgtgc
     9961 tggccagtgt attttgcgcg ttgccgcaac gctcttgttg ttactcggta cggtcgtcgg
    10021 cccgtagggc gtttgcctgg tttcgctcga agatcgcact tcgagctgct gaggcgaggt
    10081 gactctgtgc acggagggag aggccgaggc ggttccagtg gaagatcacg tggaggctga
    10141 ggatgtggcg gaggccgcgg ccgagtgttc cgtggtcggc cgcctcgcgc aggctgcggc
    10201 cagcgttttg aaaggctgtc gcccattctt cgaactgtcc gagcgggccg ccgcgtgcga
    10261 agagggcact ggtgtcggcc aagagcagcg tgcggatctg ctgtacacgg ttggttaggg
    10321 catccggcgc caggccggtg aagtcggcgc ggtgttcggc ggtgatgacg cggttccaga
    10381 cgtcgccggt ctcgtaccac tccaggccgg cgctgcgcat catggtcgtg caaaggagga
    10441 cggacagctc gcggagcccg gtgggcaggc gggtgtcttg ggcgccgaac tgctggatct
    10501 ggaggctgtc ggtcgcgaag aggtggtggg cgatctgcat gctcgtctca ccgccgaagg
    10561 cagcggtttc aggctcgtag acgacggtct gacactcccg gatgtgtccg tcggcgacga
    10621 gttggttcag ggcagccttc gccttcgctt tcgctgaggg gctggccagg acacgcacgc
    10681 ggtagccggg ctgtttgcgc atgaaccacc agctgtcgat gtcggtggct cgcagtaggg
    10741 ggagaagatg ggtggtgaag gcgcggtcgc cagtagaggg ttcggtgaag gcgaggttga
    10801 tctgccacca cttgccctcg gcagcgtgct gcaccagggc ttcgcggccg gctgccgcga
    10861 agagggatac agcgtcgcag aggtggtcgg gcgtgaggct gtggtgcagg gcgacctcgt
    10921 ccaccgcgtt tccggcgagg acttcgcgga cggctccttc gatgacgctc gtggctgcgg
    10981 cgctcagttg atcagcaggc atgcgtccca tccgttgtcc gggggcttgc tgtgggcgag
    11041 ggtggagagg gcaagggccg tgcctgcagc gccttccaga agccctctgc ccttggcagt
    11101 gttcgggcga gcatgagtga tgagggccac ggcgagttgg tggcgcaggc caggtaggcg
    11161 ggggtcgttg gagtcgtcgg tggcgcgtac gacggtttgg tagatgcccg cccagccgtg
    11221 gcagaggccc gcgtcaacga cgactcggag ctgtgccggg gcggtcaacg cccggtagag
    11281 ggcgtcctcg taaagggctt ggcgggtggt gtcgccgagc gagatcccgg cgagttgtcc
    11341 ggcgcgggcg atgccggtgg tgccgtagca ccaactcggc cgcccaggac ggtcctgccc
    11401 tgggcgacgg cgctgcacgt cctcgtacga aaggtacgtg ggccaccaag ggccctcggg
    11461 tgcgtcctgg cgccaggtgt cgaggaagtc gcagatgatg cgtatcgcgg tgcggtggcc
    11521 ttcgaccttg atgccggtgc ggagggcctt tgccaggagg aggagcgggc cggtgatgcc
    11581 gtgggcggtg ccgaggttgg cgtggccccc ggggaagtgg tcgctgtggg cgcggagcgg
    11641 gtcgtgatgg acccaccagc cgggcaggtc ggagccgttg agagttcggg gtcgggtgag
    11701 ggcgaccagg taggcgagta cgcggccgag agcactgctg cccgggtcgg tgcgtaggag
    11761 gtaggcgccg atgccggtga ggccgtagaa gaggtcgtag tcggcgaagg ccaggggctc
    11821 gccggcgcgg agccgttggt cggccgcgtc ggcacgacgg tgggcgagcg cggtgacctg
    11881 cctgtggagg gtggcgcggg cgtcggcgta gaggtgctct ctgtcgtgtg gggttgcgct
    11941 caggaggaag gcgacggctg tggcaccgag gaacaggccg ccggtgtcgc cggcgttgac
    12001 ctctccagcg gtggcttcgg cgatcaaacg gtgggctggg cgccacggtt ggtcgtgcca
    12061 ggccctttcg acgaacaaca gagctgttcc ggcggcgccg acggcgagtg actgtcccgc
    12121 gtcggggggt ttgggcggct gcggccttgc ctcgttcacc aaggcggtga actgctgcag
    12181 caggtccgcc gcagagacgg tggtggaggc gggagccgtc atcgtgtcgt cctcaagttg
    12241 cgcagtgccg ccgcccgcac cagtcgtacg gtgaccgctt cgctcatggg gtcggtattc
    12301 acggcccgca ggtggtgctg gtggatcagg gaccgcgcgg cggtgaacgg gtcccgttgc
    12361 ccggccaggg catggcggta ggcatcggcg gcgtcagcgc gtgactgcca ggcggcaacg
    12421 acccgctccc cgccgggaag atcggcgagg ggccctgccg cggagtcggc caggtggagg
    12481 gcctggtcgc gtaccttccg atcgaggggg ccggtggagc ggggcaggtc ggcgacgagg
    12541 cgctggaagc cgtcgtcagg gcagggggcg agccgactgg cgaggtggaa ggcgctcgct
    12601 gcggcgaggg cctgcggtga gaggcggttg cggtcggcga aggtgagttg cgcgagggtg
    12661 gcggtggagt cctcggcgaa cagccggtgc gcggcgtcca tcgcctcgtc gtagccccac
    12721 cgtccggtct ggggctggta ggggacgagg gcgaaccccg acgacaggcc gagggagtag
    12781 agctctgcgg cccaggcgtt gaagacttcc aggacctcgg cgtgggtgcc gggcctcggg
    12841 tgcagggtga gggtgagctg ctggtcggcg tcggcgtggg agagttcgcg gcggcggctg
    12901 aaccaccatg tcggggcacg atcgtcgagc gtggtgagaa ggcgtgaaag gtggcgggtg
    12961 aggatgtccg cgaagcgcag ggggtcggcg tggatgcggg cgtggagcgc gttgccgccg
    13021 ggcagttggc ggtcgctggg ggcgacggtt cgcacggggg cgggcaggcg gggcgccggg
    13081 gcctgcggca gggcgaggga gatccagaac tcggtggcgc ggccggtcca tccgtgggcg
    13141 gcatcgccgc aggaggtctc ccgcatctcc agttcgtggg cgtcgccgat ctgggtgcgg
    13201 acgagttggc ggtgcacggg gtgggtcagg tcgacgggaa gcacctggtc gtagtcgacg
    13261 acggcgacct ggtccgggac ggccatccgc gcccgccacg agtcgaaggc cgcgtcccac
    13321 tgcgcgccgg tggcccggcg gccggggagg tcggtggctt tgaggagcca gcgggccggg
    13381 cgcaggacgg tgcggccgtg gcggacgcgg ggcaggtagg gcaaccgcga ggcggcgccg
    13441 aagtcgaaga gaccgtagac ggcgctgcgg gccgtgctga cctcggcaag gaagcgggcc
    13501 aggacggggg tttggaggcc ggcttcgagg gcgtgtacga cctggaggtg gatcgttcgg
    13561 ccggtgggaa ggtggaccag ccggagagtg cgagcatcgg ccgtcacgcc gatctccgtg
    13621 agggggagga ccgattcgcc gggaacgccg gagccgccgt cagtgtgctt ccagccggag
    13681 atctccagca cgcggggcag gaggagcggg gtgcgggcca cgttcgtgtt gcgggcccgc
    13741 cggggcgtga acaccagttg cgcgtcgagc gcttccgggg agcccgcgta agtggcggcg
    13801 agtgccttgc gtgcgtcaga gggcagggca tgggcgaatc gccccgccag gctgctggcc
    13861 ggccgcggca tcgcggtgag caccgcccgg aagtcgccgc gtgcgagggc ggcgccgctg
    13921 ggggcgtgga tctcgaagcc tgcctccacg cggggagcca gtatccgctc gtcgctgccg
    13981 gctgcggcct ccagagtggc gaccgtctcc ttggtgagca gcagctcgcc ccgaccgttc
    14041 atgagggcct gctgcaccaa ggcgagcagc acgtcgtcgc gtgcggtgtg ggccttcgga
    14101 acactctcgc gtgtcacacc gtcgtagccc gtcggcaggc cgaggccgct gtcagcgacc
    14161 aggtccggca ccggtaccac ggcgcccggg ccgtaacggt cgcggaagcg gttgtggtag
    14221 tcgagccagg cccagcgccc gtagggctgc ggggtggttc ggtaggcggc ggtgacggct
    14281 gccgtgactt cgtcgatcac ggcgggtggg atctgcacgt cgcagtcgag ggccgtgtcg
    14341 acgtgcaggg gccggtccgt gacgtcggtg acggctgtca tgcgggaggc gatgacgtcc
    14401 aggccgtctg tggtgagggt cggctgacgt ccggacaggt cctcgcggat cgcacgaagg
    14461 gcttgtacgg tctcctggac gtcgggcact tcgtccgcgt gcacgtcgtc cagtgcgcga
    14521 cacaagtggt cgagggcgtc ggtcgtggtc atcggcgccg gcagagaggt caacaggaac
    14581 tgctggtcga cgagttcggt gagcagggtg tggacctgct cactcggtgc cctcgggaac
    14641 tgggtgcgca gacgtgcgtg caggtctcgg taggggatcg gggtgcgggc ggcttccatg
    14701 gtggcggcga ccggtggcct gttacggatg gatatctcga tcgggccgag cgtgtggtcg
    14761 aaggcgaggg agggcggccc cggggcgacg agacggcctc ctcgtacgtg ggctacgtcg
    14821 ttggcgagca gcggaagacg ttgcaggagg cccggactgc ggtgaaggcg cttgatcacg
    14881 gcggcgatcc actcgccgtc ggtccggacc gtcattgggt gcttgtcccg ccactgtgcg
    14941 ccgacttgtg ggccgactgt ggccggggcg acgccggaga acaaaccgag cggtgtggac
    15001 cggtgctgcc agcgcaggag gtaggcgacg gtggacgagg cggcccgccg gacatctctc
    15061 gcgctgcggg tcgggtcgcc gatcagcgtg cgaaccgcgt tgctcagccc aggggatgcg
    15121 aggctcagcg cgtggtggac cccgggccgc ccccagacgc gctccaacca gagacgagtg
    15181 ctggtcgggt cgtcgaggtc cagtgtgcgg ggtacgtcgg ccgcgcccgg cagggtgctg
    15241 gcgcgcagga gagcgagacc ttgccacgtg tacgtgctcg ctcgggaggt catggtgctc
    15301 cttcggtcaa cttgggggcg gtaccggtgg tccgggtgcg cggtgcgccc ggaccaccgg
    15361 ctggagagcc tggatcaggc agggtctccc gcggcggagt cgcacgcgga cgcgccgttc
    15421 gagcaggtgc ttccgcagcc gtcgccggtg tcgcacatca gagcgccgtt gagcttcgtg
    15481 ctgacgacga ccgtgacgtc cagcggtgcg aagtcgtcgt cctcgtccag caggggcggg
    15541 gctgtcggca gcagggtggc agtgggcatg gttctcgtcc ttccttgtcg gttgttgtgg
    15601 tgacgacctg gtcctcggcg ggcatcgcgg ggagctcccg gcggtcttcg cggggagccc
    15661 cgccgactac gccgggggcc aggagaggga gatccggctg tgccgcttct cgatgacgcg
    15721 gtcgcccggg accgcctcgt cgggtgtgcc ggccgggtgg acccggatga gggggtccga
    15781 gccgccgcgg tgctcgcggt cccacgcgcg cacgctgccg gcgacggtgt tcgcgaaggt
    15841 ggaggcgtcc ggaccgaggg cgtgtacgcc gaactcggcg cgttcgtcgt cgggggtgcg
    15901 gcgcgtggtg acataggcga aggtgccccc gtccacggcc gcggccgaga agcccttgtg
    15961 gcgaggggag acgatcccgg tgtcgagctg ggggtcgacg gacatgacgc agaacccggg
    16021 caggtcgatg gccaggtgca tctggagacc ggagaagggt tcgccgagcg ccacagtgac
    16081 gccggtccac tgctcgacgc gcggtgtgcg gacggcgttg tcgagcaggt gggggtcggc
    16141 gggggctccg tcgtcgaagc gcagggcgat ctcgggggtg ccgttgacga ggacttgggt
    16201 ctcgtcgtgc tggtcggagc cctgcatggc gacgaagccg cagaccagtg cggaggtgct
    16261 ctccagatgg ccgccgtggg agtcggtgac ccgctggaag gcgacggaac gggtcaggcc
    16321 gcgcatgcgg agcggcacca cgagacggcc gttcggactg agttggtcga cccaggcggg
    16381 cgggatgtcc caggcaccga cggtcaccat gatgacgtcg acctcgccga ggcccgggat
    16441 gggctgggag gcgtcggcgg tcaccacgcg gacccgggtg tagccgtggg cgtcgaggag
    16501 tcggcgggcg cggccggtga cctcggggtc gatgtcgacg ctggtgacgt tcccttcctg
    16561 gcctacgagt tcggcgaggt aggccgcgtt caggccgccg gatccgatct ccaggacccg
    16621 gtcaccagcc ttgatcccgg cctgctccat catcatggcc tggatctgcg gtgcggagac
    16681 cgaactgagt tgcaccccgt tctcgccggt cttggtgatc acggcggcgt agggggaata
    16741 cgcgtcgtcc agagaggtgt cgggcgcgaa cgcgtgccgg ggcacctgcc gcatcacctt
    16801 ctcgacgaag ggcgacacga tcaccccgtc agccttcaac tggtccacac agccgttgcg
    16861 tagacacgtc gcctcgggcg gttcggtggt cgtgctggtg ttcatcgatc gttccttcgt
    16921 aagcgcaggg ggagggaatg gcggctgccg tgggcccgga aactatcggc cggcgcgacc
    16981 cgcgtgcgcg gattcgctga accgtcggcg attcgcgtcg cggtagttcc gcaggtccgc
    17041 cagggcgttg ccgaggtcac cggacgagct cggcggcggt gagaggcccc atctcggatg
    17101 cggtggtggc cggtcgggac gctggtcggt ccattcggtc cagtccgagc gggcggtgat
    17161 cagtgcaggc cgtatctcgc ggtccaaccg gtctgcctgc gagcgcagtt gtgcggacag
    17221 agcggcgagg ccgtccgggg tgcggtcggt gatccagcag tcgtcggtca ggcgcaggtt
    17281 gacgacgggc acgcggcagg cgggttgttc ggcgaagggg atgcagtcga tgctgccgtg
    17341 caggatctcg atgtcgcagg gccggccact ggcgtgtgag gggctgtaga cggttacggt
    17401 ctgtccgggg aactcagcgt ggtgcgtgat gtctgacagg cgcacgggca gctcggtggg
    17461 cgggacgccg tcctcgctgg ggtcgcagtc ggcccaggac ggcaggggcc ctgccacggt
    17521 atggccgtcg cgggtggtga tcctccagca gcgcgggagc tgccggtacg gcggtcggtg
    17581 aggcgctgcc gcggcgcgag ctgggggagg tcgaggacat cggttcgtct ccttgctgtg
    17641 gtgcggcagg tcggcaggcg ttgtgacgcc cgtcctgaac aagggtgttt cacggccact
    17701 gcggccggag cgggagtcga ggacgaggcc gtcctacggc gggcgggcgg tcgcttcgta
    17761 gcgcgccgcc gcctgttcca gcaggccctg caccgcgagg gcccatcgcc tcaagcaggc
    17821 cacgtcggga ggcacatggt cgtcgtggcg tacgtcgtcc atgaccgact gcacgacggg
    17881 gacgaagccg gcgctcggag gtacacgcga tgcgaggcgg cgcagcgttc cgagcagccc
    17941 aggtgccagc tcgcggaccc gcccgccttc gaggacgccg aactccggct ctgagaggac
    18001 cgcttcgagg gtgtcgaggt cggtgtcgtc gaccggcagg tcggccaggt agcggtccgc
    18061 ctgcgacagc gccagtagcg tgtgggtcct ggcaatggtc gccgcgtcgt tgctgtagcc
    18121 cttccgcgga gggcagaccg tcctcgtcgt cgtccgagga gtgcgcgtgt gagcttcgtg
    18181 cgcggtgcgg aacgtggccg acgcggataa cgcgccgggt cgttccccgg tcggtactcc
    18241 gccgtcgatc gccggagcgg gtgcggcagc ggcagcggca gccgcgccca gacgatcttc
    18301 ccggggcgat cgtcggggta agcgaacccc catgcgttcc ggcacagttc ggcgacgacg
    18361 tgcagcccgc ggccgctctc cgccgagtcg gacggcagcc ggaggaccgg cgcctggttg
    18421 ctctcgtccc agaccgagat gcacaggccc cgaggaacgg tccacaattc cagagggcac
    18481 ctggatgtaa cggaccggcg gcccttctcc gattcgctcg gcgcggccca agtcgaggca
    18541 tggctcaccg cgttcgtcgc cagttccgtc acgatcgtga gcgcgtcgta agcggagtcg
    18601 tccgggatcc cccaacccgc gagggtattc atggcgtgtc tgcgggcggc tggaacggcc
    18661 gccggctcgc aggtcagcgc caggctgctg tggtagccgg actcgggagc catcttcaca
    18721 cctttcgcag gattgcgaat cggtcgccgt gcttgtggtc gacccggggg tctcggcgac
    18781 ggctctgtac agtgaacggc ggtccggcgt acggcggaca ggaagagcac gccgcccccg
    18841 cgcgccccgg gccggaaaac tttgcgggct cgttactcgt gctctggtgc ggaacgcatt
    18901 ggtgtcgtta ctttcggctc atggcagcga acgccttgct gaagaagcgc atggccgatc
    18961 tgggcctgaa gcttccccgt ggacctggac acctggagac tgggacgtga ggtcccagag
    19021 gaagtagtgc caggtgagca acaaagcagg gaagcggtac tcgaaggagt tcaagcggga
    19081 cgccgtggcg ttggcccgat cctccagcaa gacggttacc gaggtggccc gggatctggg
    19141 cgtgagcccg gagggcctgc ggagctgggt caagcaggac cagatcgacc gcggtgaggg
    19201 cggcccgggc gagctgaccg gtgccgagca cgaggaactg cggcgcctgc gccggcagaa
    19261 catcgaacag caaaggacca tcgaggtcct gaaaaaagcg acggccttct tcgcgcggga
    19321 gagcgagcgg tgagcgaggt ctaccggttc atcgcggcgg agaaggccac ctacccggtc
    19381 accttgctgt gccgcattct cggagtgcac cgctcctcct tctacgcgtg ggccgagggg
    19441 caggtcgccc ggggcgcgcg gctgcgtgcc gatgacgcac tcgcgcacga gatcactgtg
    19501 atccacctcg cctcccgggg cgcctacggc gtcccgcgcg tacatgccga gctgcggcga
    19561 ctggggcacg cggtgaacca caagcgggtc gagcggctga tgcgtgaacg ccgcatcgcc
    19621 gggatcaccc gccgccaccg caggtcgctg acacgcccgg acaagcaggc ccggcccgca
    19681 ccggacctga tcggccgcga cttcaccgcc gaccgccccg ggacccgctt ggtcggcgac
    19741 atcacctacc tgcctaccga gcagggctgg ctctacctgg cctgctggct ggacctggcc
    19801 actcgcgagg tcgtcggctg gtcaatggcc gaccaccacc gcgccgacct ggtcgtcgac
    19861 gccctgcaca tggcccacga ccggggccgc ctggaacccg gctgtatcgc acacagcgac
    19921 cgcggcagcg aatacacctc agcccaattt cgaacggcag ttaccgagtt ggacatgaag
    19981 gtaagcaccg gacgcaccgg ctcgtgctac gacaacgccg ccgccgagag cttctgggca
    20041 gtcctgaaag ccgagatcgg cacccggacc tggcccgacc gggccaccgc ccgcgccgcg
    20101 gtcttctcct acatcgagac cttctacaac cgccgtcggc tacgcaagca ccccgactgg
    20161 ggctatctga ccccgcaaga gacccgacaa cgacacaccc tcgccgcgta agaacgagtg
    20221 tccgagatca cggggaaact tcagcctgac gcaggaagaa ctcgcggtcc ggatgaacga
    20281 cgtgatcctg aaggtcaccg gccgcccggg agacgtctcc gatcggacgg tccgcaacct
    20341 gctgagcggc agtaccgttc gcccgatcgc gcgcacatgc gctgccttgg aggcggtttt
    20401 cagttgccgt gtcgaggact tagggttcaa gccaccacgc tccgcagcac cgcaggaggt
    20461 tcctgtgcgg cgtcgcacgt tcatggcctc ggccgccggc acagcaactg ccggactcgc
    20521 tccggcactt gccggcccga acagggtcgg ctccagcgat gtcgcccggc tggagacgaa
    20581 gttcgcggcg atcatcgccg aggaccacaa gtacgggggc ctggtcagca ccgagacgcg
    20641 cgcttcggcc atggccggtg aagcgctgtc gctcctccaa cgcggctcga ccagccagct
    20701 ggtccggaac aagctctacg cctccgcggc gggtttcacc tccagtgcca tgtgggcggc
    20761 gatcgacggg cgccgcttca acgaggccca gcgctacttc gaccgcgcct ccaccctggc
    20821 ggccatgtcc ggcgacgcga cgatcatgtt ccgtatctgg tcccacgcgg gcaccctcta
    20881 ccggcacctc ggacgcccca tcgacgcgtt ggccgcgaac gacgtggcca gaggacttcc
    20941 cgtcgcacgc cgcgacccga tgttcgcctc actcgggcag tcgcggcacg cagcgattct
    21001 cggtctcacc cgggactcgg tggccgttga acgttccatc gcccaggcgc aggccgccta
    21061 cagccgtgcc gatccggacg cccaacgacc cgcgtggatc acggcgttct acgaccaggc
    21121 cgagatcgag agccttgctc tcaccgcgta cctggcgctc ggcgacttcg agcgggccga
    21181 agctcatgcc caccgcggga tcgcccgtct ccgccctcac atgagacgca gccgcgccat
    21241 tgccaccgcc cgcctcgcac acgcccaact gggccagggc gatgtcgacg ctgccgtcgc
    21301 gaccgccgtc ggcacgcaga gcacacaccc gcgcgtcacg cgcatgctcg aagagttcgg
    21361 caacaagttg tccatccagg cgccgcgcag cgatgcggcg aagacctgga acgaccacgc
    21421 ctcgacgcga agggacgcct cgtgacgtca acggccatcg acctgcgcca cttccgcgac
    21481 atcgaaccgg cctgggacac gctgatcgat ctctacgccg aggtgcgcgc cgacaaactg
    21541 cacgaccccc actactccgt ggagcgctac gccgaacgcc tcgcccgcca cgcccatgag
    21601 ccgggttggg aggctgtcat cggatacgac ggcgacgaag ccgtcggata cgcgtacgcc
    21661 aacaccgtcg agcaggacga ccggtactgg aagaggatca ccacgcccct cgccgattcc
    21721 gtgaccgcgg ttccgaccct ggcgctcaag gagatcggcg tacgcgtccc ctggcgcaag
    21781 accggtgtgt cgaaggccat ccacgacagt ctgctcgccg cgcgaagcga gacgcaggcg
    21841 acgctgatgg tcaaccccct ggccggagac ggcaaggttc acaacctcta cgtctcctgg
    21901 gggtacggcg acctgggcga aagccagccg tcgccggact ctccggtcct ggtcgcgatg
    21961 gtgcgggcgc ttccctgacg gcgcccctcg cccgcgggct acgttcggag aacttgccgc
    22021 ctcctttcgt gtcgtgctct ccgagttcga caacgccctc gtcgaccgca ccggcacgct
    22081 ccctgattgg gcagccgcgt tcatcgacgg caaggtctgg gtgccgaaga gtacgagtac
    22141 atcctgagcg tgttcagccg gcgggcgtgt ccatccacct tcgacgtgat ccgcacctgc
    22201 gatcgtctgt tcgcgtcgac tgccaggcat gcgggatgcg tacggttgcg gcaccttagg
    22261 ctagcgtcgc gcctcatcga cttaatggcc gaattgccgc tttccccgca gttggttcaa
    22321 cgcggcccgg gtctctggca aacccgcagg tcagtcagac tgctccccgc gcccgcgggg
    22381 atggacccgg agagtaggac cagacgatga gcctgttcgg ctgctccccg cgcccgcggg
    22441 gatggaccgc ctcgccccgg gaccccgcga cgatcgcggc gctgctcccc gcgcccgcgg
    22501 ggatggaccc tccgccgcgt gacccccggc tcagcgctcg ggctgctccc cgcgcccgcg
    22561 gggatggacc cggccgggtg taggagcccg gccgatccag tggctgctcc ccgcgcccgc
    22621 ggggatggac ccaagatcgg tagcgacagc aagtcggcgg gtcgctgctc cccgcgcccg
    22681 cggggatgga cccggccagc ttgcgcgagg cggtcatcgg acgacctgct ccccgcgccc
    22741 gcggggatgg acccggtacg acgccgacac ccacaccctg cacctgctgc tccccgcgcc
    22801 cgcggggatg gacccagcgc ggctgacctg tagaggagca tcaccatctg ctccccgcgc
    22861 ccgcggggat ggacccgacg gtgcagcggc agttcgcctt accgaggcct gctccccgcg
    22921 cccgcgggga tggacccagc ccacccggag gaggagccca tggctgaccc tgctccccgc
    22981 gcccgcgggg atggacccgg ccagcttgcg cgaggcggtc atcggacgac ctgctccccg
    23041 cgcccgcggg gacggacccg gccagcttgc gcgaggcggt catcggacga cctgctcccc
    23101 gcgcccgcgg ggatggaccc ggtacgacgc cgacacccac accctgcacc tgctgctccc
    23161 cgcgcccgcg gggatggacc ccgatcatcg cagctcaggc cccctgattc agtctgctcc
    23221 ccgcgcccgc ggggatggac cccaggtctg ctccgcgacc aacccgaagg cgtactgctc
    23281 cccgcgcccg cggggatgga ccccgtccgt cgcggggacg acgtgatgca tagtcctgct
    23341 ccccgcgccc gcggggatgg accctcccgg ccgggcgcat ggcgcggatg cggtccctgc
    23401 tccccgcgcc cgcggggatg gacccggaac cgaaaagatc ttccgtgtgg gcacgaactg
    23461 ctccccgcgc ccgcggggat ggacctgagt gatggccccg ggcggtcacc cgaggccact
    23521 gctccccgtg cccgcgggga tggacccgac gggtcaccgg gcacgggctg ggagtttccc
    23581 tgctccccac gcccgcgggg atggacccaa catgcgcgca ggcaactggc tggcctcagt
    23641 ctgctccccg cgcccgcggg gatctcgcag tgcgcctggg cacgcgcatg atgaccgcgg
    23701 ccgggcagga cttctacgag cagggcgaca tctgggccca ggtcgccgaa catcggacag
    23761 acgccggcgc cccgcagccg gggacgccga ccttgaccgt ggtgcagctc ctcgtcaccg
    23821 ccgcgagcga cagtcccgga agccccctga cgctgacgcc ggattggccg acagccttcg
    23881 aagacgccgg acgtgctctc gccggcctcg ctcaacaagg cgctctcacc cggggactac
    23941 gggccatcct caccgaccac ctgctcttcg ccttcaaccg actcggcatc cccgcccagc
    24001 accaggacct gctggccacc gccgccagca aagtgatctt ccaccggcaa ccggcagccg
    24061 acgacactcc gtacggcagc cggaacgacc acgtccagcc ccttactgtg aagacggtga
    24121 ccacggacat gacggaccag acgaccacag aacctcagcg gctgcgcgaa gccctcgttg
    24181 ctttcatcga ccgcctcggc acgttccgca cccccgaggt gaaggccgcc ttccgcagcg
    24241 tgccccgcca cctgttcctc cccggggtgg acctggccac ggcttacgcc cgcaaggccg
    24301 tcgtcacaaa gcgcgctgcc gatggcacgg ccgtctcctc cgcctccgga cccaacatcg
    24361 tggccaccat gctcgaacaa ctccaagccg cacccggcca ccgtgtcctg gagatcggcg
    24421 cggccaccgg catcaacgcc gcccttctga ccgaactggt cggccccacc ggccacgtca
    24481 cctccatcga gctcgacgac gacctcgccg aaggcgcccg cacccacctg gccgccgccg
    24541 gatacggcca ggtcgaggtc gtctgcggcg acggcgccct cggccacccg gccggcgccc
    24601 cctacgacag gatcgaagtc accgccggag cctgggacat ctccgccgcc tggtggcagc
    24661 aactcgccct cggcggacgc atcgtcgtac ccctgcgcct ccacggcagt ggcctgaccc
    24721 gctccctcgc cttcgaccgc accgaagagc accggatgcg cagcatcaac gccgccgtct
    24781 gcggcttcgt acccatgcgc ggcgcctccg aaatgggcga acgccacgtc cgcctcgccg
    24841 acgacgtcat cctcaaactc gacgccgacg acctccccga cgagcctgcc ctcgcccaag
    24901 ccctgaccca ccgcgcccac cagcagtgga ccggcatccg ggtccgccac gaggaacccg
    24961 ccgcccacct cgacctctgg ctcgccacga tcgacagcga cctcagcttc ggccgcctgt
    25021 ccatcggccc ggaggcccac actctcggcc tggccgcccc cgccatccgc tgggccggcg
    25081 ccactctcta cgacggcggc accatctcct acctcacgac ccgacccatc gacgacggca
    25141 ccgacgaact gggcctcatc actcacgggc cggacagcaa caaactcaac tcccaggccg
    25201 tccagctact taaccgctgg agcgccgagc gccccgccca accggtcatc accgcgtacc
    25261 ccgccgccac ccccgacgat cagctcgccc ccg
//
