LOCUS       NZ_AP018365            21158 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  Streptomyces sp. SN-593 chromosome.
ACCESSION   NZ_AP018365
VERSION     NZ_AP018365.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. SN-593
  ORGANISM  Streptomyces sp. SN-593
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Panthee,S., Kito,N., Hayashi,T., Shimizu,T., Ishikawa,J.,
            Hamamoto,H., Osada,H. and Takahashi,S.
  TITLE     beta-carboline chemical signals induce reveromycin production
            through a LuxR family regulator in Streptomyces sp. SN-593
  JOURNAL   Sci Rep 10 (1), 10230 (2020)
   PUBMED   32576869
  REMARK    DOI:10.1038/s41598-020-66974-y Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Takahashi,S., Toyoda,A., Sekiyama,Y., Takagi,H., Nogawa,T.,
            Uramoto,M., Suzuki,R., Koshino,H., Kumano,T., Panthee,S., Dairi,T.,
            Ishikawa,J., Ikeda,H., Sakaki,Y. and Osada,H.
  TITLE     Reveromycin A biosynthesis uses RevG and RevJ for stereospecific
            spiroacetal formation
  JOURNAL   Nat Chem Biol 7 (7), 461-468 (2011)
   PUBMED   21642985
  REMARK    Publication Status: Online-Only
REFERENCE   3
  AUTHORS   Panthee,S., Takahashi,S., Takagi,H., Nogawa,T., Oowada,E.,
            Uramoto,M. and Osada,H.
  TITLE     Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds
            from Streptomyces reveromyceticus SN-593
  JOURNAL   J. Antibiot. 64, 509-513 (2011)
REFERENCE   4
  AUTHORS   Takahashi,S., Takagi,H., Toyoda,A., Uramoto,M., Nogawa,T., Ueki,M.,
            Sakaki,Y. and Osada,H.
  TITLE     Biochemical characterization of a novel indole prenyltransferase
            from Streptomyces sp. SN-593
  JOURNAL   J Bacteriol 192 (11), 2839-2851 (2010)
   PUBMED   20348259
REFERENCE   5  (bases 1 to 8833490)
  AUTHORS   Takahashi,S., Ueki,M., Toyoda,A., Ishikawa,J., Sakaki,Y. and
            Osada,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2017) Contact:Shunji Takahashi Chemical Biology
            Research Group, RIKEN Center for Sustainable Resource Science
            (CSRS); Hirosawa 2-1, Wako, Saitama 351-0198, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Phrap v. 0.990329
            Genome Coverage                   :: 16x
            Sequencing Technology             :: ABI 3730
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016756395.1-RS_2024_05_21
            Annotation Date                   :: 05/21/2024 03:58:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,420
            CDSs (total)                      :: 7,334
            Genes (coding)                    :: 7,181
            CDSs (with protein)               :: 7,181
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 153
            CDSs (without protein)            :: 153
            Pseudo Genes (ambiguous residues) :: 0 of 153
            Pseudo Genes (frameshifted)       :: 35 of 153
            Pseudo Genes (incomplete)         :: 136 of 153
            Pseudo Genes (internal stop)      :: 8 of 153
            Pseudo Genes (multiple problems)  :: 25 of 153
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:29:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3680692
            Orig. end                         :: 3701850
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP018365.1.
            This work was done in collaboration with Shunji Takahashi, Masashi
            Ueki, Atsushi Toyoda, Yoshiyuki Sakaki and Hiroyuki Osada (RIKEN)
            and Jun Ishikawa (National Institute of Infectious Diseases).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21158
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="20"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21158
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21158
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11158](-)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11158)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     misc_feature    683..697
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.73"
                     /tool="antismash"
     misc_feature    1306..1321
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.66"
                     /tool="antismash"
     gene            complement(3069..4652)
                     /locus_tag="RVR_RS15160"
                     /old_locus_tag="RVR_4266"
     CDS             complement(3069..4652)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009188744.1"
                     /locus_tag="RVR_RS15160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4266"
                     /product="metallophosphoesterase family protein"
                     /protein_id="WP_202234355.1"
                     /transl_table=11
                     /translation="MDTPRMGIGAELAGKLSMAEQHEYLRSRLSRRRLVLGGAVAAGTV
                     AASGLLGQSASAAAPTLVGRPATGHGVDGALVAPFGRHLQYGADPRTQFTVSWQVPLAV
                     TRPFVRYGLKPWALSHKIQAEVRDLHTPQLPGSSLPAVDQYYQHVTLTGLHPGTTYYYG
                     VGHDGFDPADAAAFATIGSFTTAPSGSERFTFTAFGDQGVSYHALANDSLILGRNPSFH
                     LHAGDICYADPDGNGTSADSGDYDARTWDQFLGQTESVASRVPWMVTTGNHDMEAWYSP
                     NGYGGQEARWTLPANGPRPANQPGAYSFVYGNTAVVALDANDVSYEIPANYGISGGGQT
                     AWLDHTLAAYRKQRGIDFLVVFFHHCAYSTTNQHASEGGVRDVWVPLFEKYQVDLVING
                     HNHVYERTDAIRAGSVSKSLPIGATVRPATDGVVYVTAGGAGKSLYSFPVPDSYEGHVQ
                     DLDSVPTYYQAKGGHVAETVHWSRVRYTGYSFLSVDVQPAHAGGESTLTVSAIAESGER
                     IDHFTVARRA"
     gene            complement(4832..5221)
                     /locus_tag="RVR_RS15165"
                     /old_locus_tag="RVR_4267"
     CDS             complement(4832..5221)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018959965.1"
                     /locus_tag="RVR_RS15165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4267"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_202234356.1"
                     /transl_table=11
                     /translation="MGHGRVTKDSGATTRERLDAVGTADVAATLQALATPSRLHILARL
                     QEGPCSVGDLAEAVGMEASACSHQLRLLRNLGLVAGERNGRSIIYALYDDHVAELLDQA
                     LYHVEHLRLGVRDVPADAALPASAD"
     gene            5407..7518
                     /locus_tag="RVR_RS15170"
                     /old_locus_tag="RVR_4269"
     CDS             5407..7518
                     /GO_function="GO:0042625 - ATPase-coupled ion transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009193383.1"
                     /locus_tag="RVR_RS15170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4269"
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="WP_272933084.1"
                     /transl_table=11
                     /translation="MPPALVQRSAPPASGPRPTAPPRRRTRVLALPEARWALAAVVSFL
                     LALPLHLSGGPAWLGGTLFAATYATGGWEPGWEGLKALRDRTLDVDLLMVVAALGAAAI
                     GQVLDGALLIVIFATSGALEAVATARTADSVRGLLDLAPATATRLLPGGGEEVVHTERL
                     AVGDVVLVRPGERIGADGEVLDGASDVDQAGITGEALPVVKEAGDEVFAGTVNGTGALR
                     VRVARDPADSVIARIVRMVEEASGTKAPTQLFIERIEQRYSIGMVAATLAVFALPLLLG
                     EALRPALLRAMTFMIVASPCAVVLSTMPPLLSAIANAGRHGVLVKSAVVMERLGQVDAV
                     ALDKTGTLTEGTPRVTGVLATAAAGAGGQDAVLRLAAAVEHPSEHPLARAVVDAARQRG
                     LDLPPVEGFDYTPGAGVSGTVAGRTVQVGSPARLLADAASVPRGADVRADAVGRSTEVA
                     QPTAVAHGGPAVGARAAVDAARAEAARLEAEGRTAVVVVADGVPLGVLGIADRLRDEAA
                     AAVRALGELAGGTPLLVTGDNPRAAARLAAEVGITDVRAGLLPQDKVDAVRELAAAGRK
                     VLVVGDGVNDAPALAVAHSGVAMGKAGSDLALETADAVVVRDELTAIPSVVRLSRAARR
                     LVLQNLAVAAVFITGLVVWDLAGSLPLPLGVAGHEGSTVVVGLNGLRLLREAAWPRPSG
                     SPRTPPTPK"
     gene            complement(7694..8230)
                     /locus_tag="RVR_RS15175"
                     /old_locus_tag="RVR_4272"
     CDS             complement(7694..8230)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044105.1"
                     /locus_tag="RVR_RS15175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4272"
                     /product="hypothetical protein"
                     /protein_id="WP_202234357.1"
                     /transl_table=11
                     /translation="MPSPCDPQYAPVGDVGTALLMVDSRLKAVHDGSAEEDPRQRQLID
                     QFTASMSPEEADDVLDGACTLVYLYARWLTAAYEDHGKDVVEYVVPDLVATMRQMPRSI
                     RPEAIPTMAGMVIAAAGGLGPGLWRKQYGYWTESEMTPLEVTAFLLAERINHLTDDRQF
                     ATRLISNALSSAAQD"
     gene            complement(8511..9884)
                     /locus_tag="RVR_RS15180"
                     /old_locus_tag="RVR_4275"
     CDS             complement(8511..9884)
                     /NRPS_PKS="Domain: Beta_elim_lyase (41-418). E-value:
                     1.2e-75. Score: 246.4. Matches aSDomain:
                     nrpspksdomains_RVR_RS15180_Beta_elim_lyase.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061276.1"
                     /locus_tag="RVR_RS15180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4275"
                     /product="tryptophanase"
                     /protein_id="WP_202234358.1"
                     /transl_table=11
                     /translation="MEPYRIKVVEPIPVTTRQQREEALKRVHYNLFDLRAEEVTIDLLT
                     DSGTGALSAAQQAAGMAGDESYSGSRSFYRFHETVTELTGYSHILPAHQGRAAERVLFN
                     TLLEPGKLVLANTHFDTTRANVELSGAEARDLPCPEARDLDSTHPFKGNIDLEELRRTL
                     TGPDGSRVAVVLLTITNNGGGGQPVSMENIKQTSALCRAHGVPFFLDAARFAENAWLVT
                     RHEPGYQDRTPRQVAEEAFRLTDGCVMSAKKDGIVHIGGFIGLNDGELAQRCELLLIAT
                     EGFATYGGLAGRDLDMMAQGLKEVTEPSYLAERADIATHLANRVRSAGVDILEPPGLHA
                     LYLNAGRLFPHIPAHHYPGHALACQLYLEGGIRSAELGSLYLGEEDEEGNPTKSAPYEL
                     VRLALPRRVYTRSHYDHVGETLEKIVKNAGSVHGFRITEQSPILRHFRATLVPVPVTG"
     aSDomain        complement(8631..9761)
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RVR_RS15180_Beta_elim_lyase.1"
                     /evalue="1.20E-75"
                     /label="RVR_RS15180_Beta_elim_lyase.1"
                     /locus_tag="RVR_RS15180"
                     /protein_end="418"
                     /protein_start="41"
                     /score="246.4"
                     /tool="antismash"
                     /translation="DLLTDSGTGALSAAQQAAGMAGDESYSGSRSFYRFHETVTELTGY
                     SHILPAHQGRAAERVLFNTLLEPGKLVLANTHFDTTRANVELSGAEARDLPCPEARDLD
                     STHPFKGNIDLEELRRTLTGPDGSRVAVVLLTITNNGGGGQPVSMENIKQTSALCRAHG
                     VPFFLDAARFAENAWLVTRHEPGYQDRTPRQVAEEAFRLTDGCVMSAKKDGIVHIGGFI
                     GLNDGELAQRCELLLIATEGFATYGGLAGRDLDMMAQGLKEVTEPSYLAERADIATHLA
                     NRVRSAGVDILEPPGLHALYLNAGRLFPHIPAHHYPGHALACQLYLEGGIRSAELGSLY
                     LGEEDEEGNPTKSAPYELVRLALPRRVYTRSHYDHVG"
     gene            complement(10001..11158)
                     /locus_tag="RVR_RS15185"
                     /old_locus_tag="RVR_4274"
     CDS             complement(10001..11158)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358092.1"
                     /locus_tag="RVR_RS15185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4274"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_237404762.1"
                     /sec_met_domain="indole_PTase (E-value: 2.9e-139, bitscore:
                     462.7, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTGGRSPMCDTVGSSLARLEPTQLGGLVTDQLARLCDVARLDRT
                     DTETYVQTLATSLGTAAERSLALPPTTATLLSDDHTPVEYSLAFLPGATPALRVLVEPG
                     WDSGDLAENGRAGLRAIRAMADRWNFSTDQLDLLEDLFFPVAPAGPFALWCALELRPGG
                     VPGVKVYLNPAARGRDRRAETLREALDRLGHRQAFAALPPADDYPFLALDLGEWAAPRV
                     KVYCTHESLSAQEAGEYSRLAAADGRDQTTDFFHAVAGTDAGGTGQPSTRRALTCHSFT
                     DTVTGRPSGFTLHMPVRSYVEHDGRARDRAADVLRRYGMDNDALDRALAAVTPRPLDDG
                     VGLVAYVALVHQLGRDPRVTVYVSSEAYAVQPPRTALATGPGIGR"
     misc_feature    complement(11277..11292)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.0"
                     /tool="antismash"
     misc_feature    11278..11291
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.18"
                     /tool="antismash"
     misc_feature    11469..11484
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     gene            complement(11514..12839)
                     /locus_tag="RVR_RS15190"
                     /old_locus_tag="RVR_4276"
     CDS             complement(11514..12839)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005332.1"
                     /locus_tag="RVR_RS15190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4276"
                     /product="cytochrome P450"
                     /protein_id="WP_202234359.1"
                     /transl_table=11
                     /translation="MSTDQGFPSPPPGCPAHGRVPLHGPEFQADPDSYYAWMRNFGPTA
                     PVELAPGVEATLVTDYSAALQLLQDPDTFRKDSRRWRAFNEGKVSPNSPVVPLLAYRPN
                     CMFTDGADHLRLRQAVTDTIARVDSHQLKRQVDRVSRYLIGQFSSRGSVDLLNDYAKML
                     PILFFSELFGCPAEIGDRIIFGINGIFDGVNAEKANEVLAQSVAELVALRRAHPGEDVT
                     SWLMQHPAQLNDEEMVHQLVLLLGSGAEPLRNLIGNSLCLILSDDRYSDGGLLVEDAID
                     EVLWNNPPMSNYAPHYPVADIEFAGRRIDAGELVLVSFAAANTDPALSGSRQLLSKRAH
                     LAWSTGPHGCPAKDPAQLITIAAIENLLNQLPDIELAVPVDSLSWRPGPFNRALATLPA
                     RFTPVREQVPQQPQNRQATASQQAQGKQKGGLWSSFLAWWKV"
     gene            complement(12836..13438)
                     /locus_tag="RVR_RS15195"
                     /old_locus_tag="RVR_4277"
     CDS             complement(12836..13438)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525690.1"
                     /locus_tag="RVR_RS15195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4277"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_202234360.1"
                     /transl_table=11
                     /translation="MGSRPDSADGVYLDGAVKTAAKILVVGHFAVGKTTFIGTMSEIPP
                     LRTEERMTQAGALVDDLHGVRGKTTTTVAMDFGRITLSEHLVLYLFGTPGQERFVQVWE
                     DMTRGALGALILVDPERLQESFPVIDLVEQYGLPYAISVNHFDDTPVRSDEELRDALDL
                     LPETPIVTCDARDQKSSADALIALVRYLQTRTTRSTT"
     gene            complement(13413..13784)
                     /locus_tag="RVR_RS15200"
                     /old_locus_tag="RVR_4278"
     CDS             complement(13413..13784)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574206.1"
                     /locus_tag="RVR_RS15200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4278"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_202234361.1"
                     /transl_table=11
                     /translation="MNHPDEPVAQSTDLVRPYVITNGRGLPADDKFNLITLVTASDQPR
                     PVHLDPEKHSVLDLCSGGMLSVAEIAGHMKLPIGIVKVLLSDLASEGYLVVRPPVPRAQ
                     LADVSLLQEVLNGLQARFG"
     misc_feature    complement(13743..13745)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13781..14182)
                     /locus_tag="RVR_RS15205"
                     /old_locus_tag="RVR_4279"
     CDS             complement(13781..14182)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324213.1"
                     /locus_tag="RVR_RS15205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4279"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_202234362.1"
                     /transl_table=11
                     /translation="MNNDLSWMLESALEVPGARHAVLISADGLLMARSQQVRKDEADTV
                     AAAMSGIQSLSRTMGGFCGDVNMSWRQTLVEFDGGWVFLISAGAGAYLAVSSAPDVDMA
                     AITFRMQQLVGQLGKVLTAPPRENTSTQV"
     gene            complement(14179..15327)
                     /locus_tag="RVR_RS15210"
                     /old_locus_tag="RVR_4280"
     CDS             complement(14179..15327)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015575702.1"
                     /locus_tag="RVR_RS15210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4280"
                     /product="ATP-binding protein"
                     /protein_id="WP_202234363.1"
                     /transl_table=11
                     /translation="MTHYIQDPALWALIVGAPTAATVIFRGRKARARLRAEKAELENRY
                     AELEGGYSESVREARVRAEDATKSALKSAMRTLQGLANEQQVTISKAQDKFGEHHVLQD
                     LLEIDHMNSQFGRRAQSIAVLCDGWLGRQRVAASVYDVVRSAKGRIRHYTRVEIRSQTN
                     FALIGRAVEPVALALAELLDNATSYSAPDTPIDITTRSVPKGVCIIIDDAGVGMNEEEK
                     ARADELLSGQGPVGVAGLGNPPQFGFAVIGVLAQRYGFNVSVDSSSPYGGVRAVVLLPE
                     ELLTNMPEPKEPPASRSAAAAPASHGATTGPGAPAERSATSTPGGLPRRSRKGSISIVP
                     SVDAPAAPPTRTHEEAASIMGAFQLGTQSGRRSANREGHESQ"
     misc_feature    complement(15304..15322)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.31"
                     /tool="antismash"
     gene            complement(15922..16497)
                     /locus_tag="RVR_RS15215"
                     /old_locus_tag="RVR_4281"
     CDS             complement(15922..16497)
                     /GO_process="GO:0006950 - response to stress [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845870.1"
                     /locus_tag="RVR_RS15215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4281"
                     /product="TerD family protein"
                     /protein_id="WP_202234364.1"
                     /transl_table=11
                     /translation="MGVTLSKGGNVSLSKEAPGLTAVTVGLGWDVRTTTGADYDLDASA
                     LLCDTAGKVLSDQHFVFFNNLASPDRSVEHSGDNLTGGGDGDDEQIKVDLAGVAPQVDR
                     IVFPVSIYEAEGRGQSFGQVRNAFIRIVNQADGRELARYDLTEDASTETAMVFGELYRH
                     GAEWKFRAIGQGYASGLAGIASDFGVNV"
     gene            complement(16631..18475)
                     /locus_tag="RVR_RS15220"
                     /old_locus_tag="RVR_4282"
     CDS             complement(16631..18475)
                     /GO_process="GO:0070726 - cell wall assembly [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069554.1"
                     /locus_tag="RVR_RS15220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4282"
                     /product="LCP family protein"
                     /protein_id="WP_202234365.1"
                     /transl_table=11
                     /translation="MSDPWGRPAGGPPEGRVRHGRGPEPPGPRSGSHDAGHGGRRARAR
                     GADPDSDGGGISAGHAAGAGRAADAPPTGGRAAARAAARGRGGSSARRKKGGSRAKRPS
                     GGRRFLRIAAITVSLLVVVTAGAGWWFYQHLNGNLTSVSLTDGVGKDSAGTEKADAFGR
                     KPINILVMGSDGRTSAEDCKLGGGCATTGVQTGENADVEMVLHISADRSNATVMSIPRD
                     TEVDVPACTDPKTGAKTAGYHGMINSALAYGQACQVATVHKLTNIPIDHFIQVDFSGVV
                     DMSDAVGGVQVCVSGDVYDTYSHLKLSKGTHTLKGVGALEFLRSRHGFGDGSDLGRTYA
                     QHAFLSSLIRKFKSAGTLTNPTSVYKLANAATKALTVDTGLGTIKKLIGLAGDVNKVPT
                     KRITFTTMQTAADPTDANRVVVGAGAETLFSTIADDKSLTTASGGKSAAATATASPTPT
                     VPASQVTVSVQNGTAVPGRAGDIADALVAKGFNPATSSGNADPTDTTALTYGSGQKAQA
                     QTVAKALGLPSSHLKQGTSDGVTLVIGSDWSTGTSFPGGTSSSSDTKQALADAHAETAD
                     KSTTCAQVSTYKTVEINGVPMTPGQAYAASPGKKDSDE"
     gene            18793..18999
                     /locus_tag="RVR_RS15225"
                     /old_locus_tag="RVR_4284"
     CDS             18793..18999
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007383629.1"
                     /locus_tag="RVR_RS15225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4284"
                     /product="hypothetical protein"
                     /protein_id="WP_346731456.1"
                     /transl_table=11
                     /translation="MTWETAELEGGPADGTRVRVAGRPRVLQVAVACPVEEGASGVSVT
                     AVSVYRRKSGPAPLRYGWDGASP"
     gene            19458..20876
                     /locus_tag="RVR_RS15230"
                     /old_locus_tag="RVR_4285"
     CDS             19458..20876
                     /GO_process="GO:0070726 - cell wall assembly [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019359166.1"
                     /locus_tag="RVR_RS15230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_4285"
                     /product="LCP family protein"
                     /protein_id="WP_237405315.1"
                     /transl_table=11
                     /translation="MVSALVLLASGCGWIALHAGDPHTFTADGISGKRPASGDGQNVLL
                     IGSDSRAGGNRALGGGSGTVGRSDTTLLLHVYADRRHAVGVSVPRDALVDIPPCLLPDG
                     TWSAPQKDVMFNAAFATGLTADGNPACTQNTVEQLTGLRVDHTVVVDFSGFAAMTAAVG
                     GVQVCLPQDVYQRDLSPGRTTRGALVFHRGLQSVSGQQALDYVRIRHGIGDGSDIGRMK
                     RQQAFLAALFRKIKAKGFNPTVLLPLANAAVHSLTVDPGLGSAPDLLEFAMSLKDIDLD
                     NVRFVTAPWRYDGPRVALVHPAADRLWAALRANRPLPSTGSAPAPTSAAPAGSPSAATD
                     RPGAGIDVAVDNATTVSGLAARAAAALTSAGFTVTRTGNAPGQAPAATVVEYGTASGDR
                     TDAAAVARQFSGAVVRPSPTGAAGVRVVLGPDYADATAASAPPEDTSPPRAASDSPCSD
                     LSYGGPSATPSSAP"
     misc_feature    complement(21119..21133)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 acgccggcgg cgcggcggcc cccgacccgg tggccgacac ctactaccgg gtcctgctcg
       61 accacacccg ctggtcggag acccagtggg acgcggccaa gggctactac accgccaccg
      121 acttcggctt cgccgtcgtc ctcggcaacg cggtcctgct cacccacggc agctacgacg
      181 ccgacaaggc cggcatcgac gcggccacgc tgaaggaccg gaccgtcgcc tcgatcgcgc
      241 acttcgccgc ctccaaccgc aacaacggcg gcaccgagtg gggcaggacg ctcttcttcg
      301 acaccacctt ccagttgtac ttcgcgctcg ccgcccgact gctgtggaac gacctcgaca
      361 ccgccacgcg gggactcgtc gactcgctga tccgcgacca ggccgcgtac accacctcgc
      421 tcggcaccgg cgacgacccg ctgtcctccc cctggacccc caacgggctg aagggcggct
      481 ggcagggcga caccaaggtc gacgagatgg gcgtctacgc ccagtcgctg gtgcccgcgc
      541 tggtctgggc gcaggacgac ccgcggtacc cggactggct ggcgtcctac cgggcctggt
      601 cgcggaacga gacgggcctg ccggcggcgg acctggccaa cccggcgacg gtggacggga
      661 ccgcggtcag cgccaacacc gggcacaacc tgtgggacac cttcctcgtg gagaaccacg
      721 gctccttcga gccgcactac caggaggagg tgtggcgcac ctccgcccgc accgcgatcc
      781 actacctgac cgcgggacac gcgctgccgc aggtggtcac cgaccagccc aacaccggcc
      841 cgctgtggcg cagcatcctc aacgtgatga gcgacgcggg cgagccgttc atgccgatga
      901 tcaacgaccg ggagcacctg tacgggcggg acgtcatccc gctggcgttc caggcccagg
      961 tgatcggcga ccgcgccgcc gcccgggccg aacaggccat ggccgaacgg ctggaggcgt
     1021 accaggcgta cccgccgcag taccggctgg cgaagttctc cggcgagccg aagtacgagc
     1081 cggaggcccg cgccgaggtc gccatcagct acctgctcca cctgtgggcg gcgcgctcgg
     1141 gacggaccgt gcgggcgctg tcggaggcgg agttcttccg gcaggcgtcc ggtgtcatgg
     1201 acttcggcgc cggcccgggg ctggtctcgc accagtcgtc cggcgcctgg gcgggggcgg
     1261 tgagcaaggc cgggttcgtg aagttcccct ggcagccggc ccacgacgac tggctgttca
     1321 agctcagcgc cgccaccgcg gtgttcctgc cggcggtcac cgggaccgtc gccggccgcc
     1381 gggtgcgggt ctaccaggcc gtgcgcgacg gcttcgacgg cagcgcgacc gtgctggacc
     1441 tcgggtccgc cggccgcgcc ggcctcacca ccctgccgtc cggcgcggtc gtctacgcca
     1501 ccaccgggac cggcgcgggc gagggccacc tggaggtcta caacctcacc atgccgggca
     1561 tgcccggcct caccggctcg cgcacctacc ggtacgccga gggcagccac accgtggcgg
     1621 ccgccgacgg cgacggcggg accgccggcg gccgggtgga ccaactggcc ttcccccgca
     1681 ccgaggtccg ctacctgcgc atgcagggcg tccagggcga ccccacctac ggctactcgg
     1741 tctacgagtt cgaggcccgg gacggcgccg gcggcgccga cctcgcccag ggcggcaccg
     1801 ccaccgcgtc ctcctccgac accggactgg gcgccccgct ggccgtggac ggcagcacca
     1861 ccacccggtg ggcggtctcc cgggccgacc ggctgcgggc cgacagctgg ctccaggtgg
     1921 acctcggttc cgccgaggcg gtggaccggg tcaccatccg ctgggaggcg gccgccggac
     1981 ggaagtacct cgtccagggc tcctccgacg ggcagacctg gaccgacctg gcgtcctggc
     2041 ccaccccgga cctgaccagc accggcggct ggctcgacgt ggacggccgg gccgggttgg
     2101 tggtgcgcgg ctcggcgctg ccgctgtcgg tctacgggga caccgtggtg ctcgccgacg
     2161 gcccgtccgc gccgctgctg gtcgaggggc tgcccggcgc ctcggccggc accctgcgcg
     2221 ccctggcggg gcggccggtg ccgcggccgg cggccgacgg cgtgcgggcg gccctgaccg
     2281 aggaccacct cagcctgttc aacctgaccg gctcggcggt gtccaccacg gtcgcggtgc
     2341 cgtccgccgg caccggacgg gtgctgttcg acggccggca gacggtcacc tccgacggga
     2401 cctcgctgga ggtccggctc gacgccgcct cggcggagct cctcgccccg cgcctcaccc
     2461 tggaaccgct ctccggccgc cggctgccgt ccggcctggt cgccgaggtg gtcgacggcg
     2521 ccacggtgcg gctgtccggg gcgtccggcc aggtgcgggt gaccggccag gggcgcagcg
     2581 cggtggcgac cgtccgcggc accgccaccg tccggttggc cggggccacc gccttcccgc
     2641 tggacgacct ggcgctgggc cggaccgtct tcccgaccga cccgctgccc gcggggatgt
     2701 ccgacccgcg gacggccgtg gacggcgacc cgcacaccgc gtggacgccc ggcccgaagg
     2761 ggcggatggt ggtggacctc ggcgcgtcgg tggcgttcac gcaggtcagc gccgagtgga
     2821 ccggcggccg cgtgcccgtc ggccgggtgg aggtcagcga cgacggcgtg agctaccgcg
     2881 ccgcgggcac cctgtccggg tccgggccgc gccggcagct cgccgtcggg gccaccgccc
     2941 gctacgtcgc cctggcgacg gacgccgccg accacggcgg cgcgcgcctg gtggccctct
     3001 cggtgcgctg acgtgcgacg ggggtgccgc accggtggcg gtgcggcacc cccggacggg
     3061 acgggccgct acgcccggcg ggccaccgtg aagtggtcga tgcgctcgcc gctctccgcg
     3121 atcgcggaga ccgtcagcgt cgactcgccc ccggcgtggg cgggttggac gtcgacggac
     3181 aggaacgagt agccggtgta gcgcacccgc gaccagtgca cggtctcggc gacgtggccg
     3241 cccttggcct ggtagtaggt gggcaccgag tcgaggtcct ggacgtggcc ctcgtaggag
     3301 tcggggaccg ggaaggagta caggctcttg cccgcgccgc ccgcggtcac gtagacgacg
     3361 ccgtcggtgg ccggacggac ggtcgcgccg atcggcaggg acttcgacac cgagccggcc
     3421 cggatcgcgt cggtgcgctc gtagacgtgg ttgtggccgt tgatcaccag gtccacctgg
     3481 tacttctcga acagcggcac ccagacgtcg cgcaccccgc cctcggaggc gtgctggttg
     3541 gtggtggagt aggcgcagtg gtggaagaag accaccagga agtcgatgcc gcgctgcttg
     3601 cggtaggcgg ccagggtgtg gtccagccag gcggtctgcc cgccgccgct gatgccgtag
     3661 ttcgccggga tctcgtacga cacgtcgttc gcgtcgaggg cgacgaccgc ggtgttgccg
     3721 tacacgaagg agtaagcgcc gggctggttg gccgggcggg ggccgttggc cgggagggtc
     3781 cagcgcgcct cctggccgcc gtagccgttg ggcgagtacc acgcctccat gtcgtggttg
     3841 ccggtggtga ccatccacgg cacccgggag gccaccgact cggtctggcc gaggaactgg
     3901 tcccaggtcc gcgcgtcgta gtcgccggag tccgcggacg tgccgttgcc gtcggggtcg
     3961 gcgtagcaga tgtcgccggc gtgcaggtgg aaggaggggt tgcggcccag gatcagcgag
     4021 tcgttggcga gcgcgtggta gctcacgccc tggtcgccga acgcggtgaa ggtgaaccgc
     4081 tcgctgccgg acggcgcggt ggtgaacgag ccgatcgtgg cgaaggccgc ggcgtcggcc
     4141 gggtcgaacc cgtcgtggcc caccccgtag taatacgtcg tgcccgggtg caggccggtc
     4201 agcgtgacgt gctggtagta ctggtcgacc gcgggcaggc tgctgccggg cagttgcggc
     4261 gtgtgcaggt cccgcacctc cgcctggatc ttgtggctca gcgcccacgg cttgaggccg
     4321 tagcggacga acggcctggt gaccgcgagg ggcacctgcc aggagacggt gaactgcgta
     4381 cgcgggtcgg ccccgtactg gaggtgccgg ccgaacgggg cgaccagcgc gccgtccacg
     4441 ccgtgcccgg tggccgggcg gcccaccagg gtcggtgccg cggcgctcgc gctctggccg
     4501 agcagcccgg acgcggcgac ggtgcccgcc gcgaccgcgc cgcccagcac cagccgccgc
     4561 cggctcagcc gggaccgcag gtactcgtgc tgttccgcca tgctcagttt cccggcgagc
     4621 tcggcgccga tgcccatgcg aggagtgtcc atgacgggga agctgccatc gcgggcggat
     4681 gcccgggcgt acggaaggcg aacggccggt gtcggaaggc cgtccgcacg cctcccccgg
     4741 cggcggggtg gtgcgcccgt gacgggtggg acgggccgcg cggaagggac ggcccacagc
     4801 cgggcgggcg cctggccggc aggccggcgg gtcagtcggc ggacgcgggg agcgccgcgt
     4861 ccgcgggcac gtcgcggacc ccgaggcgga ggtgctccac gtggtagagc gcctggtcga
     4921 ggagttcggc gacgtggtcg tcgtagagcg cgtagatgat cgagcggccg ttccgctcgc
     4981 cggccacgag cccgaggttg cggagcaggc gcaactggtg ggagcaggcc gacgcttcca
     5041 tgccgacggc ctcggcgagg tcgcccaccg agcacggccc ttcctggagg cgggccagga
     5101 tgtgcagccg ggagggcgtc gcgagtgcct ggagggtggc ggcgacgtcc gcggtgccga
     5161 ccgcgtcgag gcgctcgcgc gtggtggcgc cgctgtcctt ggtgacgcgt ccgtggccca
     5221 tggcaccatc ataacgatga cacttgaaga actcttcaga tgttcatgta ccatacggaa
     5281 ggcgtccggc ccggtctccc gggcccgtgg cgtgccgacc ggtcacgggc ccgtccgtcc
     5341 cgcctccgtc gtacgccgtc cacctcctcc gcccgtgacg ggctcgcctc gaagggtcgg
     5401 tcttccgtgc ctcctgccct ggtccagcgg tccgcgccgc ccgcgagcgg tccgcggccg
     5461 accgcgccgc cccggcggcg cacccgcgtg ctggcgctgc ccgaggcccg gtgggcgctc
     5521 gcggccgtgg tgtccttcct gctcgccctg cccctccacc tgtccggcgg gccggcctgg
     5581 ctggggggca cgctgttcgc cgcgacctac gccaccggcg gctgggaacc gggctgggag
     5641 gggctcaagg cgctgcgcga ccggacgctg gacgtggacc tgctcatggt ggtcgccgcg
     5701 ctgggcgccg ccgcgatcgg ccaggtgctc gacggcgcgc tgctgatcgt catcttcgcc
     5761 acctccggcg cgctggaggc cgtcgccacc gcccgcacgg cggactccgt gcgcgggctg
     5821 ctcgacctcg ccccggccac cgccacccgg ctgcttcccg gcggcggcga ggaggtcgtc
     5881 cacaccgagc gcctggcggt cggggacgtg gtcctggtcc ggcccgggga gcggatcggc
     5941 gccgacggcg aggtgctgga cggcgcgagc gacgtcgacc aggccggcat caccggcgag
     6001 gcgctgccgg tggtcaagga ggccggcgac gaggtgttcg ccggcaccgt caacggcacc
     6061 ggcgccctgc gcgtacgcgt ggcgcgggac ccggcggact cggtgatcgc ccggatcgtg
     6121 cggatggtcg aggaggcgtc cggtacgaag gccccgaccc agttgttcat cgagcggatc
     6181 gagcagcggt actcgatcgg gatggtggcc gccacgctcg ccgtgttcgc cctcccgctg
     6241 ctcctgggcg aggcactccg gccggcgctg ctgcgggcga tgacgttcat gatcgtggcg
     6301 tcgccctgcg cggtggtgct ctccaccatg ccgccgctgc tgtccgccat cgccaacgcc
     6361 ggacggcacg gcgtcctggt caagtccgcg gtggtgatgg agcgcctcgg acaggtcgac
     6421 gcggtcgcgc tggacaagac cggcacgctg accgagggca ccccgcgcgt gaccggcgtc
     6481 ctcgcgacgg ccgccgccgg cgcgggcggc caggacgcgg tgctgcggct ggcggcggcg
     6541 gtcgagcacc ccagcgaaca cccgctggcc cgcgcggtgg tggacgccgc acggcagcgg
     6601 ggcctcgacc tcccgccggt ggagggcttc gactacacgc ccggcgccgg ggtgagcggc
     6661 accgtggcgg gccgcaccgt ccaggtcggc agcccggccc gcctgctcgc cgacgcggcg
     6721 tccgtcccgc gcggggcgga cgtccgggcg gacgcggtcg ggcgatccac cgaggtcgcg
     6781 caacccaccg ccgtcgcgca cggcggcccc gccgtcgggg cacgcgccgc cgtcgacgcc
     6841 gcgcgggcgg aggccgcccg gctggaggcg gagggccgta ccgccgtggt ggtcgtcgcc
     6901 gacggggtac cgctgggcgt gctcggcatc gccgaccggc tgcgcgacga ggccgccgcg
     6961 gccgtccgcg cgctcggcga actggccggc ggtacgcccc tgctggtcac cggcgacaac
     7021 ccgcgcgcgg cggcccgcct ggccgccgag gtcggcatca ccgacgtgcg cgccggactg
     7081 ctgccgcagg acaaggtcga cgcggtacgg gagttggcgg cggccggacg gaaggtgctg
     7141 gtggtcggcg acggcgtcaa cgacgccccc gccctggccg tcgcccactc gggcgtcgcg
     7201 atggggaagg ccgggtccga cctcgcgctg gagaccgcgg acgcggtcgt ggtgcgcgac
     7261 gaactcaccg cgatcccgtc cgtggtgcgg ctgtcccggg ccgcgcgccg gctcgtgctc
     7321 cagaacctgg ccgtcgccgc ggtgttcatc accgggctgg tggtctggga cctggccggc
     7381 agcctcccgc tgccgctcgg cgtcgccggc cacgagggat ccaccgtcgt ggtcgggctc
     7441 aacggcctgc gcctgctgcg cgaggcggcc tggccgcgcc cgtccggctc cccgcgcacc
     7501 ccgcccaccc caaagtgagc gaacccgccg agagcgcgcg gcccggacgc ggggtcgggc
     7561 ccggacgccg ggtcaggggc cgggtcaggg gcgcgcgcgg ggccgagggc acgggacgcg
     7621 accgcgggca cgggatcagg cccggggccg ggggcgggca cgggatcagg cccgggcggt
     7681 cagcggcgcg ggatcagtcc tgggccgcac tgctcagggc gttgctgatc aggcgcgtgg
     7741 cgaactggcg gtcgtcggtc aggtggttga tccgctcggc gaggaggaag gcggtgacct
     7801 ccagcggggt catctcgctc tcggtccagt agccgtactg cttgcgccac aggcccgggc
     7861 ccagaccgcc cgcggcggcg atcaccatgc cggccatggt gggaatcgcc tcggggcgga
     7921 tactccgggg catctgccgc atcgtggcga cgaggtcggg cacgacgtac tcgacgacgt
     7981 ccttgccgtg gtcctcgtag gccgcggtca gccaccgggc gtacaggtag acgagcgtgc
     8041 aggccccgtc cagcacgtcg tcggcctcct cggggctcat cgacgcggtg aactggtcga
     8101 tcaactgccg ctgccggggg tcctcctcgg cgctgccgtc gtggacggcc ttgagccggg
     8161 agtcgaccat cagcagggcc gtacccacgt cgcccaccgg ggcgtactgg gggtcacagg
     8221 gcgatggcac cgggttcctc ctcaactcac cgcgccgggc gcggcgttct ggcgtcgtgg
     8281 tccccgacga ctgtagggcc gcgcggtccg ccgggaccgg gccgaggcgt tgccccgtca
     8341 cacaggcagg ccgtccgggc acgctccgtg cgcaccccgc cgtcctgcgg cccggcgcgg
     8401 cggaggaggc cgcgcgcggg agacccgccg cgccggaggc gtacacggcc gcggcccggt
     8461 ccctcctcgg gcccgggccg cggccggcgg cggtacggag tgcgtccggc tcagccggtg
     8521 accggaaccg gcacgagcgt cgcccggaag tgccgcagga tcggggactg ctcggtgatc
     8581 ctgaacccgt ggacgctgcc ggcgttcttg acgatcttct ccagcgtctc gccgacgtgg
     8641 tcgtagtggc tgcgcgtgta gacgcggcgc ggcagggcga gccggaccag ctcgtagggc
     8701 gcgctcttgg tcgggttgcc ctcctcgtcc tcctcgccga ggtagaggga gcccagctcc
     8761 gcggagcgga tgcccccttc gaggtagagc tggcaggcca gcgcgtggcc cgggtagtgg
     8821 tgcgcgggga tgtgcgggaa cagccggccc gcgttgaggt agagcgcgtg caggccgggc
     8881 ggttcgagga tgtccacgcc cgccgagcgc acccggttcg ccaggtgggt ggcgatgtcg
     8941 gcccgctcgg cgaggtagga cggctcggtg acctccttga ggccctgggc catcatgtcg
     9001 aggtcgcggc cggccaggcc gccgtaggtg gcgaagccct cggtggcgat gagcagcagc
     9061 tcgcaccgct gggcgagttc gccgtcgttg aggccgatga agccgccgat gtggacgatg
     9121 ccgtccttct tggcgctcat cacgcagccg tcggtgagcc ggaacgcctc ctcggcgacc
     9181 tgccgcgggg tgcggtcctg gtagccgggc tcgtgccggg tgaccagcca cgcgttctcg
     9241 gcgaaccggg ccgcgtcgag gaagaacggc accccgtgcg cgcggcacag cgccgaggtc
     9301 tgcttgatgt tctccatgga gacgggctgc ccgccgcccc cgttgttggt gatggtgagc
     9361 agcaccaccg cgacccgcga gccgtccggc ccggtgagcg tgcggcgcag ctcctccagg
     9421 tcgatgttgc ccttgaacgg gtgcgtgctg tccaggtccc gcgcctcggg acacggcagg
     9481 tcgcgtgcct cggcgccgga cagctcgaca ttggcccgcg tggtgtcgaa gtgcgtgttg
     9541 gccagcacca gcttgccggg ttcgagcagc gtgttgaaca gcacgcgctc ggccgcgcgg
     9601 ccctggtggg ccgggaggat gtgggagtag ccggtcagct cggtgacggt ctcgtggaag
     9661 cggtagaagg agcgcgaacc cgagtacgac tcgtcgcccg ccatgcccgc ggcctgctgc
     9721 gcggccgaca gcgcgccggt cccggagtcg gtcagcaggt cgatggtcac ctcctccgcc
     9781 cgcaggtcga acaggttgta gtgcacccgc ttcagcgcct cctcgcgctg ctgccgcgtg
     9841 gtgacgggga tgggctccac taccttgatc cggtaaggct ccatgaggac cgctgctcct
     9901 gtctttcggt cgtgcgaact tccgtcgtgc gaaggttcct cgggtcgcgc ggggtggtgc
     9961 gcgagtggtg cgcgggtggt gcgcgggggg ttccggccga tcagcgtccg atcccgggcc
    10021 cggtggccag cgcggtgcgg ggcggctgca ccgcgtacgc ctcggaggag acgtagacgg
    10081 tgacccgcgg gtcccggccc aactggtgca ccagcgccac ataggcgacg agccccacgc
    10141 cgtcgtccag ggggcggggg gtcaccgcgg cgagcgcccg gtcgagggca tcgttgtcca
    10201 tgccgtagcg gcgcagcacg tccgccgccc ggtcgcgggc ccggccgtcg tgctcgacgt
    10261 agctgcggac gggcatgtgc agggtgaagc cgctggggcg gccggtcacg gtgtcggtga
    10321 aggagtggca ggtcagcgcg cgccgggtgg acggctgccc ggtgccgccg gcgtccgtgc
    10381 cggcgacggc gtggaagaag tccgtggtct ggtcccggcc gtcggcggcc gcgaggcggg
    10441 agtactcgcc cgcctcctgg gcggacaggc tctcgtgggt gcagtacacc ttcacccgcg
    10501 gagccgccca ctcgccgagg tcgagggcga ggaaggggta gtcgtcggcc ggcgggagcg
    10561 ccgcgaacgc ctgccggtgg ccgaggcggt cgagcgcctc gcgcagggtc tccgcccgcc
    10621 ggtcccggcc gcgcgcggcc gggttgaggt agaccttcac gccgggcacg ccgcccggac
    10681 gcagttccag cgcgcaccac agggcgaacg gcccggcggg tgcgacgggg aagaacaggt
    10741 cttccagcag gtcgagttgg tcggtggaga agttccagcg gtcggccatc gcgcggatcg
    10801 cccgcagtcc ggcccggccg ttctccgcca ggtcgccgct gtcccagccg ggttcgacca
    10861 ggacgcgcag cgcgggcgtg gcgccgggca ggaaggccag cgagtactcc accggcgtgt
    10921 ggtcgtcgga gagcagggtg gccgtggtcg gtggcagcgc caacgaccgt tccgcggcgg
    10981 tgccgaggct ggtggcgagg gtctggacgt aggtctcggt gtcggtgcgg tccagccgcg
    11041 cgacgtcgca cagccgggcg agctggtcgg tgacgagacc accgagctgc gtcggctcca
    11101 gcctggcgag gctggagccg acggtgtcgc acatcgggga gcggccgccg gtcaccatgc
    11161 gccgcccctc gtgccggcgc gcgccgggag cacttcacgg cgggcgaaaa gatacccgcc
    11221 ccgaagggcg ggttcggcag gtggagcgcc gcccggtgga cacctgcgat cgggagggga
    11281 atacacgttc gacatatccg aatgatcgac gagcccgcgg ggtatgggta aaacagcggt
    11341 gcgcgacgag gcagggggat cggcggcagc aggcacggta acaactcctt tggtcctggc
    11401 caacgatttt cgccctggtg actacccctt cggtctgacg atcatgtggg atgcaggcat
    11461 atgctcgcag tgacctgggt cacgcatgca tttcggccgt aaaaagggct ggatcacacc
    11521 ttccaccagg ccaggaagga gctccacagg ccgcccttct gcttcccctg tgcctgctgc
    11581 gaggctgtgg cctgccggtt ctgcggctgc tgcggaacct gctcccgcac cggggtgaac
    11641 cgggccggca gcgtggccag tgcgcggttg aagggcccgg gccgccaact gaggctgtcc
    11701 accggcaccg ccagctcgat gtccggtagc tggttgagca ggttctcgat ggccgcgatg
    11761 gtgatgagct gcgccgggtc cttcgccggg cagccgtgcg gaccggtgct ccacgccagg
    11821 tgggcgcgct tgctgagcag ttgccgcgaa ccggacagcg ccgggtcggt gttggcggcg
    11881 gcgaagctca ccagcaccag ctcgccggcg tcgatccgcc gtccggcgaa ctcgatgtcg
    11941 gccaccgggt agtgcggcgc gtagttggac atcggcgggt tgttccagag cacctcgtcg
    12001 atcgcgtcct cgacgagcag cccgccgtcg gagtaccggt cgtcggagag gatcaggcac
    12061 aggctgttgc cgatcaggtt gcgcaacggc tcggcgcccg agccgagcag cagcacgagc
    12121 tggtggacca tctcctcgtc gttgagctgc gccgggtgct gcatcagcca ggaggtgacg
    12181 tcctcgcccg ggtgcgcgcg ccgcagggcg accagctcgg ccacggactg ggccagcacc
    12241 tcattggcct tctcggcgtt gacgccgtcg aagatgccgt tgatgccgaa gatgatccgg
    12301 tcgccgatct cggcggggca gccgaacagc tcgctgaaga agaggatcgg gagcatcttg
    12361 gcgtagtcgt tgagcaggtc gaccgagccg cgggagctga actgcccgat caggtagcgg
    12421 gagacccggt ccacctggcg cttgagctgg tggctgtcca cccgggctat cgtgtcggtg
    12481 accgcctggc gcagccgcag gtggtccgcg ccgtcggtga acatgcagtt gggccggtag
    12541 gcgagcagcg gcaccaccgg gctgttcggg ctgaccttgc cctcgttgaa ggcccgccag
    12601 cggcgcgagt ccttccggaa cgtgtcgggg tcctggagga gttgcagggc cgccgagtag
    12661 tccgtgacga gcgtggcctc caccccgggc gccagctcca ccggcgcggt cgggccgaag
    12721 ttgcgcatcc aggcgtagta cgagtccggg tccgcctgga actcggggcc gtgcaggggc
    12781 acccggccgt gcgcggggca gccgggcggg ggcgagggga agccttggtc ggtactcacg
    12841 tcgtgctcct agtggtacgc gtctggagat accggaccag ggcgatcaat gcgtcggcgg
    12901 atgacttctg gtcgcgggca tcacaggtga cgatgggggt ttcgggcagc aggtcgagcg
    12961 cgtcgcgcaa ctcctcgtcg gagcgcaccg gcgtgtcgtc gaagtggttg acggagatcg
    13021 cgtaggggag cccgtactgt tccaccaggt cgatgacggg gaacgactcc tgcaggcgct
    13081 cggggtcgac caggatgagc gcgccgagcg cgccacgggt catgtcctcc cacacctgga
    13141 cgaagcgttc ctgcccgggt gtgccgaaga ggtacagcac gaggtgctcg ctcagcgtga
    13201 tacggccgaa gtccatcgcc accgtggtcg tggtcttccc ccgcaccccg tggaggtcgt
    13261 cgaccagggc acccgcctgg gtcatccgct cctcggtgcg cagcggggga atctcggaca
    13321 tggtgccgat gaacgtcgtc tttccgaccg cgaagtgccc cacgaccagg atcttggccg
    13381 cggtcttcac cgctccgtcg agatagacgc catcagccga atcgggcctg gagcccattc
    13441 agcacctcct gcaggagcga tacgtcggcg agttgggcac gaggcaccgg cggccggacg
    13501 acgaggtagc cctccgacgc gaggtcggag agcagcacct tgacgatgcc gatcgggagc
    13561 ttcatgtgcc ctgctatctc ggccaccgag agcattcccc ccgaacacag gtccaggaca
    13621 ctgtgcttct cggggtcgag atggacgggg cgcggttggt cggacgcggt gaccagcgtg
    13681 atcaggttga acttgtcgtc ggccggcagt ccgcgcccgt tcgtgatgac gtacggacgc
    13741 actaaatccg tggactgcgc gacgggctca tccggatggt tcatacctgg gtactcgtgt
    13801 tttcgcgagg cggcgcggtc aggaccttgc cgagttggcc gacgagctgc tgcatccgga
    13861 aggtgatcgc cgccatgtcg acgtccgggg cggacgagac ggcgaggtag gcgcccgcgc
    13921 cggcggagat gaggaacacc cagccgccgt cgaactccac cagggtctgg cgccaggaca
    13981 tgttcacgtc gccgcagaag ccgcccatcg tgcggctgag cgactggatg ccgctcatcg
    14041 ccgcggcgac ggtgtcggcc tcgtccttcc tgacctgctg ggagcgggcc atcagcagcc
    14101 cgtcggcgga gatcaggacc gcgtgacgtg ccccggggac ctccagggca ctctcaagca
    14161 tccatgacag gtcgttgttc actgcgattc gtgcccttcc ctgtttgcgg agcgccgccc
    14221 ggactgagta ccgagctgga aggcgcccat gatcgaagcg gcctcctcgt gggtccgggt
    14281 gggaggcgcg gcgggggcgt ccacactcgg cacgatggag atggagccct tccggctcct
    14341 tctcggcagg ccaccggggg tcgacgtggc ggaccgctcc gccggtgcgc cgggtccggt
    14401 cgtcgccccg tgggatgcgg gggccgctgc cgcgctgcgg gaggccgggg gctctttcgg
    14461 ctcgggcatg ttggtcagaa gctcctcggg aagaagcacc accgcacgta cgccgccata
    14521 gggggaggag gagtcgacgg acacgttgaa gccgtaccgc tgggcgagca cgccgatgac
    14581 cgcgaaaccg aactgcggcg ggttgcccag tccggccacg cccaccgggc cctggccgga
    14641 caggagttcg tcggcgcgcg ccttctcctc ctcgttcata ccgacaccgg catcgtcgat
    14701 gatgatgcag acacccttgg gcacggagcg ggtggtgatg tcgatcgggg tgtcaggggc
    14761 cgagtaactg gtcgcgttgt ccagcagttc ggcgagggcc agggccaccg gctcgacggc
    14821 ccggccgatc agcgcgaagt tcgtctgcga gcggatctcc acccgggtgt agtgccggat
    14881 gcggcccttc gcgctgcgca ccacgtcgta gacggacgcg gcgacgcgct gccggccgag
    14941 ccacccgtca cagagcacgg cgatggactg ggcccgccgg ccgaactgcg agttcatgtg
    15001 gtcgatctcc aggaggtcct ggagcacgtg gtgttcgccg aacttgtcct gggccttgga
    15061 gatggtcacc tgctgctcgt tggccagacc ctggagggtc cgcatggccg acttcagcgc
    15121 gctcttggtg gcgtcctccg cacggacccg ggcctcccgc acggactcgg agtagccgcc
    15181 ctcgagttcc gcgtaacggt tctccaactc ggccttctcg gcccgcagtc tggcccgcgc
    15241 cttccgcccc cggaagatca cggtcgcggc ggtcggggcc ccgacgatca gagcccagag
    15301 cgctggatcc tgtatgtaat gcgtcatgag actctcttca agcgactaga cgaccaccag
    15361 gcacggaaag gggctgcgtc ctggcctccg ggtagtactg atgtgcgaag atgcccgttc
    15421 cggcacccgc gcgaccacgg ggcgtcgcac gcgccttgcc ggcggcagcg cagacgcgtc
    15481 ggcatcacga gcaacaccgg tatgcccgac tgcggcatgg tgctcctcgg tgtgatggac
    15541 cctctcgaac cgatcgccgt ctgtcctgca cgctcattgg ctagcctggc aagcgggccg
    15601 atcgtaccac catgatcaga cacggggccc gcaagtgccc gcggcacgtg aaatcctgac
    15661 acttcgtcag tacaatgccc cgccgcccgc gcggacggcg gccgcccggg agcgccgctt
    15721 tgcccggatg cgtgccgtgt gggacgcggc gtgcaggggt gacgagaggg tcgcgggggc
    15781 tgaagtgccc cgtcgcgcac acatctgtga acgttcggcg aagatcggcc ggaaggcgcg
    15841 ggagcccgcc cgggggtgtc ccggacgggc tccgcggcgc cggccggccc ggcggcggca
    15901 ggcgccggcc gggccgccgg atcagacgtt gacgccgaag tccgacgcga tgccggccag
    15961 gcccgaggcg tacccctggc cgatggcgcg gaacttccac tcggcgccgt gccggtacag
    16021 ctcgccgaag accatcgcgg tctcggtgga ggcgtcctcg gtcaggtcgt accgggccag
    16081 ttcgcggccg tcggcctggt tgacgatccg gatgaaggcg ttgcggacct gcccgaagct
    16141 ctgcccgcgg ccctcggcct cgtagatgga gacggggaag acgatccggt ccacctgggg
    16201 cgcgacgccg gccaggtcga ccttgatctg ctcgtcgtcg ccgtccccgc cgccggtgag
    16261 gttgtctccg ctgtgctcga ccgagcggtc ggggctggcg aggttgttga agaagacgaa
    16321 gtgctggtcc gacagcacct tgccggccgt gtcgcacagc agggccgagg cgtccaggtc
    16381 gtagtcggcg ccggtggtgg tgcgcacgtc ccagcccagc ccgacggtga ccgcggtcag
    16441 cccgggcgcc tccttgctca gcgagacgtt gccgcccttg gaaagagtca cgcccacgct
    16501 ctacctccgg ttgatctcgt ggtgccggtt tcggccgcct gccggtcccg acgcggtggg
    16561 gcgcgccgcg gttcccggcc cgcgccgggc cccgggcgcc ccgccgcgcg gcgggccggg
    16621 gtggccgatc tcactcgtcg gagtccttct tccccgggga ggccgcgtac gcctgccccg
    16681 gcgtcatcgg gacgccgttg atctcgacgg tcttgtaggt gctgacctgg gcgcaggtcg
    16741 tggacttgtc cgcggtctcg gcgtgcgcgt cggccagcgc ctgcttggtg tcgctggacg
    16801 acgaggtgcc gcccgggaag ctggtgccgg tggaccagtc ggagccgatg accagcgtga
    16861 cgccgtcgga cgtgccctgc ttcaggtgcg aggacggcag cccgagcgcc ttggccacgg
    16921 tctgcgcctg ggccttctgc ccggagccgt aggtcagcgc cgtggtgtcc gtggggtcgg
    16981 cgttgccgct gctggtggcc gggttgaagc ccttggcgac cagcgcgtcg gcgatgtcgc
    17041 cggcccggcc ggggacggcg gtgccgttct gcaccgagac cgtgacctgc gaggccggca
    17101 cggtgggggt ggggctcgcg gtggccgtgg ccgccgcgga cttgccgccg ctcgccgtgg
    17161 tcagcgactt gtcgtcggcg atggtggaga agagcgtctc ggccccggca cccaccacga
    17221 cccggttggc gtcggtgggg tcggcggcgg tctgcatcgt ggtgaaggtg atccgcttgg
    17281 tgggcacctt gttcacgtcg ccggccaggc cgatcagctt cttgatggtg cccagcccgg
    17341 tgtcgacggt cagcgccttg gtggcggcgt tcgccagctt gtacacggag gtcgggttgg
    17401 tcagggtgcc cgcgctcttg aacttgcgga tcagcgagct gaggaaggcg tgctgcgcgt
    17461 aggtgcggcc gaggtcgctg ccgtcgccga agccgtgccg ggagcgcagg aactccagcg
    17521 cgccgacgcc cttgagggtg tgggtgccct tggagagctt caggtgggag taggtgtcgt
    17581 agacgtcgcc gctcacgcac acctgcacgc cgccgaccgc gtcggacatg tcgaccacgc
    17641 cggagaagtc gacctggatg aagtggtcga tcgggatgtt cgtcagcttg tgcacggtgg
    17701 ccacctggca cgcctggccg tacgccagcg cgctgttgat catgccgtgg tagccggccg
    17761 tcttcgcgcc ggtcttcggg tcggtgcagg cgggcacgtc gacctcggtg tcgcgcggga
    17821 tgctcatgac ggtggcgttg gagcggtcgg cggatatgtg cagcaccatc tccacgtcgg
    17881 cgttctcgcc ggtctgcacg ccggtggtgg cgcagccgcc gcccagcttg cagtcctcgg
    17941 cggaggtgcg gccgtcgctg cccatcacca ggatgttgat cggcttccgg ccgaaggcgt
    18001 ccgccttctc cgtgccggcg ctgtccttcc cgacgccgtc ggtcagcgag acgctggtga
    18061 ggttgccgtt caggtgctgg tagaaccacc agccggcgcc ggcggtgacc acgaccagca
    18121 gcgacacggt gatcgccgcg atccgcagga agcgccggcc gccgctgggg cgcttggccc
    18181 ggctgccgcc cttcttccgc cgcgcggacg aaccgccccg gccgcgggcg gcggcccggg
    18241 ccgcggcccg cccgccggtc ggcggcgcgt cggcggcgcg gccggccccg gcggcgtggc
    18301 cggcggatat cccgccgccg tcggagtcgg ggtccgcacc gcgcgcgcgg gcgcggcggc
    18361 cgccgtgccc ggcgtcgtgg gagccgctgc gcggccccgg cggctccggc ccgcggccgt
    18421 gccgtacccg gccctccggc gggcctccgg ccggcctgcc ccaggggtca ctcatctccc
    18481 actcccttgt ccgagcagcc ctcttgaggc ccgcggccgg ttacgttggg tgaagcgacg
    18541 gtttcactcc gtttcacgct tgcgcaatgc ggcaaggata ggtcataccc ctgtgcacac
    18601 ccgaagggaa aggggcccga gggacggccg ggggccgggc ccgagcggcc gcgggcggcc
    18661 cccggggccc cgggaacggg gacgcgtccg cccgccccgc caccgcgtcg cggtttccca
    18721 tggttcccgg attacgcaag ctctaaagtg ttcgccatgc aaccgacggc gacgcgaagc
    18781 gggagggcgc cggtgacctg ggagacggcc gagctggagg ggggacccgc ggacggcacg
    18841 cgggtgcggg tggccgggcg cccccgggtg ctccaggtcg cggtggcctg cccggtggag
    18901 gagggcgcga gcggggtgag cgtgaccgcg gtgtcggtct accgccgcaa gtccggcccg
    18961 gcgcccctgc ggtacgggtg ggacggcgcc agcccctgag ccgtgggggc cgcgcggcgc
    19021 acccccggga accccgaccg cgggtgggtg ccgcgcggca cccgcccccg ggaaccccga
    19081 ccgcgcgggg acggcatcgc acgtgagagc gaaccgctcg gcaccacgcc cggccccgta
    19141 ccgcgccgca ccccaactcg ggcgcggcgc aaggacgttg cgcgcccccg cggggagggc
    19201 gcggtccgac accaccgggt gacggccggc caaaccggcc cctgccccca ccaggattgc
    19261 taggttgcgc aatcggaaag cggggcaacc cggggaaacc ggatcatccg gcggttccgg
    19321 gggcatccgg ggtcgcgggg tcggagaggg agcacatgcc gggtcgtcac agcggggttc
    19381 ctggagcggg tacgggaccg gcggccgcgg ccgtcccccg gcgccggcgc agccgccggg
    19441 ggctggtggt ggcgagcatg gtctccgcgc tggtgctgct cgcctccggg tgcgggtgga
    19501 tcgccctgca cgcgggcgac ccgcacacgt tcaccgccga cggcatcagc ggcaagcgcc
    19561 ccgcctcggg cgacggccag aacgtcctgc tcatcggctc ggactcgcgc gcgggcggca
    19621 accgcgcgct cgggggcggc agcggcaccg tcggccgctc cgacaccacc ttgctgctgc
    19681 acgtctacgc cgaccggcgg cacgcggtcg gcgtctccgt cccgcgcgac gccctggtgg
    19741 acatcccgcc ctgcctgctg ccggacggga cctggtcggc accgcagaag gacgtgatgt
    19801 tcaacgcggc gttcgccacc ggactgaccg cggacggcaa tccggcgtgc acgcagaaca
    19861 ccgtcgagca actgaccggg ctgcgcgtgg accacaccgt cgtggtggac ttctccggct
    19921 tcgccgccat gacggccgcg gtcggcggcg tccaggtctg cctgccgcag gacgtctacc
    19981 agcgggacct cagcccgggc cggaccaccc gcggcgcgct ggtcttccac cggggcctgc
    20041 agagcgtctc gggccagcag gccctggact acgtccggat ccggcacggc atcggcgacg
    20101 gctccgacat cggccggatg aagcgccaac aggccttcct ggccgccctg ttccggaaga
    20161 tcaaggccaa gggcttcaac ccgaccgtcc tgctgccgct ggcgaacgcc gccgtccact
    20221 ccctgacggt ggaccccggc ctcggctccg cgccggacct tttggagttc gcgatgtcgc
    20281 tgaaggacat cgacctggac aacgtccgct tcgtcaccgc cccctggcgg tacgacggcc
    20341 cgcgcgtcgc cctcgtccac ccggccgccg accggctgtg ggccgcgctg cgcgccaacc
    20401 gcccgctgcc gtccaccggt tccgcccccg cgcccacctc ggccgcaccc gccggctccc
    20461 cctccgccgc gacggaccgg cccggcgccg gcatcgacgt ggcggtggac aacgccacca
    20521 ccgtctccgg gctcgccgcc cgggcggccg cggcgctgac gtccgccggc ttcaccgtca
    20581 cccgcaccgg caacgcgccc ggccaggcac cggccgccac cgtcgtcgag tacggcaccg
    20641 cgagcggcga ccggaccgac gcggccgccg tcgcacggca gttctccggc gccgtggtcc
    20701 gcccctcccc caccggcgcc gccggcgtcc gggtcgtgct cggccccgac tacgccgacg
    20761 ccaccgccgc gtccgcgccg ccggaggaca ccagcccgcc ccgcgccgcg agcgacagcc
    20821 cctgctccga cctgtcctac ggcggcccgt cggccacgcc gtcgtccgcc ccgtgagccg
    20881 ggtcggcggg cggcgggcgc ccgttcgctc cggcggccgg ccgaacccgg gtgcgtaccc
    20941 tgggggctgc acatcgccgc ggtctgggag gttcacgtga caaggtctgg cggacagctg
    21001 ggcgagccct cggcagaggt gctgcagagc gtggccgccg ccttcggtct gctggcctcg
    21061 ccgatgcgcc tgcacatcgt gtggatcctg gcgcagggcg actgcgacgt cacgggcctg
    21121 gccgagaagg tcggcgccac gctgcccgcg gtcagcca
//
