LOCUS       NZ_AP018365            26445 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  Streptomyces sp. SN-593 chromosome.
ACCESSION   NZ_AP018365
VERSION     NZ_AP018365.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. SN-593
  ORGANISM  Streptomyces sp. SN-593
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Panthee,S., Kito,N., Hayashi,T., Shimizu,T., Ishikawa,J.,
            Hamamoto,H., Osada,H. and Takahashi,S.
  TITLE     beta-carboline chemical signals induce reveromycin production
            through a LuxR family regulator in Streptomyces sp. SN-593
  JOURNAL   Sci Rep 10 (1), 10230 (2020)
   PUBMED   32576869
  REMARK    DOI:10.1038/s41598-020-66974-y Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Takahashi,S., Toyoda,A., Sekiyama,Y., Takagi,H., Nogawa,T.,
            Uramoto,M., Suzuki,R., Koshino,H., Kumano,T., Panthee,S., Dairi,T.,
            Ishikawa,J., Ikeda,H., Sakaki,Y. and Osada,H.
  TITLE     Reveromycin A biosynthesis uses RevG and RevJ for stereospecific
            spiroacetal formation
  JOURNAL   Nat Chem Biol 7 (7), 461-468 (2011)
   PUBMED   21642985
  REMARK    Publication Status: Online-Only
REFERENCE   3
  AUTHORS   Panthee,S., Takahashi,S., Takagi,H., Nogawa,T., Oowada,E.,
            Uramoto,M. and Osada,H.
  TITLE     Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds
            from Streptomyces reveromyceticus SN-593
  JOURNAL   J. Antibiot. 64, 509-513 (2011)
REFERENCE   4
  AUTHORS   Takahashi,S., Takagi,H., Toyoda,A., Uramoto,M., Nogawa,T., Ueki,M.,
            Sakaki,Y. and Osada,H.
  TITLE     Biochemical characterization of a novel indole prenyltransferase
            from Streptomyces sp. SN-593
  JOURNAL   J Bacteriol 192 (11), 2839-2851 (2010)
   PUBMED   20348259
REFERENCE   5  (bases 1 to 8833490)
  AUTHORS   Takahashi,S., Ueki,M., Toyoda,A., Ishikawa,J., Sakaki,Y. and
            Osada,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2017) Contact:Shunji Takahashi Chemical Biology
            Research Group, RIKEN Center for Sustainable Resource Science
            (CSRS); Hirosawa 2-1, Wako, Saitama 351-0198, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Phrap v. 0.990329
            Genome Coverage                   :: 16x
            Sequencing Technology             :: ABI 3730
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016756395.1-RS_2024_05_21
            Annotation Date                   :: 05/21/2024 03:58:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,420
            CDSs (total)                      :: 7,334
            Genes (coding)                    :: 7,181
            CDSs (with protein)               :: 7,181
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 153
            CDSs (without protein)            :: 153
            Pseudo Genes (ambiguous residues) :: 0 of 153
            Pseudo Genes (frameshifted)       :: 35 of 153
            Pseudo Genes (incomplete)         :: 136 of 153
            Pseudo Genes (internal stop)      :: 8 of 153
            Pseudo Genes (multiple problems)  :: 25 of 153
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:29:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1998427
            Orig. end                         :: 2024872
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP018365.1.
            This work was done in collaboration with Shunji Takahashi, Masashi
            Ueki, Atsushi Toyoda, Yoshiyuki Sakaki and Hiroyuki Osada (RIKEN)
            and Jun Ishikawa (National Institute of Infectious Diseases).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26445
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="14"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26445
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26445
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16445](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16445
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            <287..>413
                     /locus_tag="RVR_RS37410"
                     /pseudo=""
     CDS             287..>413
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011600011.1"
                     /locus_tag="RVR_RS37410"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRGKTDARDAHHR"
     gene            complement(456..>778)
                     /locus_tag="RVR_RS08375"
                     /pseudo=""
     CDS             complement(456..>778)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558180.1"
                     /locus_tag="RVR_RS08375"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="GRPRRLPDTVSADRAYSTV"
     gene            825..1592
                     /locus_tag="RVR_RS08380"
                     /old_locus_tag="RVR_2379"
     CDS             825..1592
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268373.1"
                     /locus_tag="RVR_RS08380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2379"
                     /product="transposase"
                     /protein_id="WP_202233249.1"
                     /transl_table=11
                     /translation="MAGVLTASESSWIAPFTGLSPRAFGKLVTVLRREGADAVRKGRPW
                     GLPLEDRALLVAAYWRTNLTMRQLAPLFGVSKSAADRIIDHLGPMLALQPRKRFAKDAV
                     LIVDGTLVPTRDHTVAEPSKNYRYSTNHQVVIDADTRLVVVVGRPLAGNRNDCKAWEES
                     GAKAAVGNTLTISDGGYPGTGLVMPHRRRNGEDLPEWKQAHNTSHKQVRARVEHVFARM
                     KTWKILRDCRLKGDGVHHAMLGIARMHNLALAG"
     gene            1734..2630
                     /locus_tag="RVR_RS08385"
                     /old_locus_tag="RVR_2380"
     CDS             1734..2630
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612292.1"
                     /locus_tag="RVR_RS08385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2380"
                     /product="IS982 family transposase"
                     /protein_id="WP_202233250.1"
                     /transl_table=11
                     /translation="MTTEKLNTLLTALYVLVDDHLPKTRRLGRPPRLSDAELVCLAVAQ
                     VLLGFHSEARWIRFAHAHLRPMFPGLPQRPAYNKRLRAARPHIQQAIRTLAQHSDLWPD
                     PVWITDSTPVECGRSRDTARRSALAGWAGYGYCASHSRWFWGLRLHLVCTPAGLPITWA
                     LATPKVDEREVLAALIETEPDLAHDRPGLLILADKGYVSAELDRFLDQYGITLLRPSYR
                     NHQPRPGQTLLKPIRQLIESVNDTLKGQLGLEQHGGRTIEGAATRVSQRILAMTCAIWH
                     NRTTGQPITHSLIAYDH"
     gene            complement(2599..3234)
                     /locus_tag="RVR_RS08390"
                     /old_locus_tag="RVR_2381"
     CDS             complement(2599..3234)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF033580.1"
                     /locus_tag="RVR_RS08390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2381"
                     /product="IS5 family transposase"
                     /protein_id="WP_272933138.1"
                     /transl_table=11
                     /translation="MNRGADGVLSRGDLTDDEWSVLEPLLPTSTGCCGRWRDHRQVING
                     IIHRLGTGCQWRQLPARYGPWQTIHKRHMLWSADGTWERLLQHVQAVADAGGGIDWDIN
                     IDPTSIRAHQHAAGAPAMPVCASSEKGHPQTGMLHEALGRSRGGFTTKIHLSADGKCRP
                     LSLIITSGQRADCTQFEAVMDKIRVPRLDLDELFRCGLFSGRRRSVSG"
     gene            complement(3231..4091)
                     /locus_tag="RVR_RS08395"
                     /old_locus_tag="RVR_2382"
     CDS             complement(3231..4091)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014055648.1"
                     /locus_tag="RVR_RS08395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2382"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_202233252.1"
                     /transl_table=11
                     /translation="MIVITGATGALNGATVEHLLKRMPAEQIGVSVRNTAKARHFADRG
                     VRVRKGSYEDPAALRHSFEGAEQVLLVSSNDPHADAVALHRVGIDAAVAAGARRILYTS
                     HQGAGVDSPFHPARDHAATEQCLANSGVAWTALRNGFYAHSLGWLLGDWQQSGTITAPA
                     DGPVSWTDRSDAAEAAAAILTGGRAFGGPVTLTARQAVTFDDVAALASKTTGREVERIV
                     LDDEAWIAAKVAAGTPEAMARMTLTTFQAAREGRFAGVGPLLGELLGREPRTVADQLAA
                     DIDAA"
     gene            complement(4145..4768)
                     /locus_tag="RVR_RS08400"
                     /old_locus_tag="RVR_2383"
     CDS             complement(4145..4768)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014055649.1"
                     /locus_tag="RVR_RS08400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2383"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_237404637.1"
                     /transl_table=11
                     /translation="MGSEPGGPQVRGADARSAMGRPRDTGRGLAILEATLSLLSEVGYE
                     QLSMEAVASRSGSAKTTIYRRYRDKAALVAAAVEHRAQATPPEPVSDDLRENLLSLVSW
                     LARQIAEQEIGLLGALFAGMRSDVRLAEEMRRILRRDEAAMTDEPLRKAIRHGEHLAPG
                     APALFAEIAPAVIVHRIMIAGEPCDGPFVAHLVDDILLPLLRSR"
     misc_feature    complement(5076..5092)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.74"
                     /tool="antismash"
     gene            5143..>5838
                     /locus_tag="RVR_RS37415"
                     /pseudo=""
     CDS             5143..>5838
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013752.4"
                     /locus_tag="RVR_RS37415"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MYGADHLRLPNELVHGWRWRVETLIVDHVLVVGNRARAAIIRSQR
                     ITGLTPAVITELVAKIGPLWHERHRTVLAARPRRRAVGAGAKHKLVFVDRLLATLVHLR
                     HGVTHDVLASWFGVDRSTITRAIGEVRPLLAERGCTVATGQRLRTVADVIDYLGAEGRT
                     GIIDGTEIRVRRPAAGRKDREKFISGKTKQNAVKSMVVTDAEGRLLFCSPAEPASCADI
                     THARKLGLVK"
     gene            5921..6169
                     /locus_tag="RVR_RS37420"
                     /old_locus_tag="RVR_2384"
     CDS             5921..6169
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS37420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_2384"
                     /product="transposase family protein"
                     /protein_id="WP_237405483.1"
                     /transl_table=11
                     /translation="MTPPHRKFKKNPPGWYEEMHERQRKAHSSRRIRVEHGIGHLKNWR
                     SLARHHGRREHMSDIIQAVAGLLSHQQAATTASRTRT"
     gene            complement(6260..6487)
                     /locus_tag="RVR_RS08410"
                     /old_locus_tag="RVR_2386"
     CDS             complement(6260..6487)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070950.1"
                     /locus_tag="RVR_RS08410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2386"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_202233253.1"
                     /transl_table=11
                     /translation="MNPNQKIELYATDLPNAKWRKSSFSNGGEQCVEVAQTRRGIAIRD
                     SKDPNGPALLFTPAAFTEFLAKVNTRQFDS"
     gene            complement(6484..7356)
                     /locus_tag="RVR_RS08415"
                     /old_locus_tag="RVR_2387"
     CDS             complement(6484..7356)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138945.1"
                     /locus_tag="RVR_RS08415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2387"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_202233254.1"
                     /transl_table=11
                     /translation="MPNVRAVPTLRRRRLGNALRAYRLAASLSGEVAGAAMGWDESKIS
                     RIENARARMPPGDVAALLKAYGVEDVDAVAALESLARDAGKQGWWQTYGDVVPLSYTDY
                     LTLESDAESVHVYTPSLIPGLLQTGAYAREIIAATAITRTAAEVTALAEVRKTRQAILT
                     TRAEGPLKLWAVIHEAALGLRSASQPTLMKDQLRHLLDMTELPNVTIQVMDLHATAHPG
                     MLGLFEVVRFPAPWPTVVNLENLRGGSFVEGTDDVKAFENAFERVVASALSVDDSRAKI
                     KDIMEGTGA"
     misc_feature    complement(7435..7449)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.52"
                     /tool="antismash"
     gene            7579..8067
                     /locus_tag="RVR_RS08420"
                     /old_locus_tag="RVR_2388"
     CDS             7579..8067
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="RVR_RS08420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2388"
                     /product="ATP-binding protein"
                     /protein_id="WP_237404638.1"
                     /transl_table=11
                     /translation="MTTYRSTVDSPLVNASPAPTVPASEHVRDEMVLRIPDRPAEATPD
                     HAPHGRWVGLLRHITAAKARQWALSSLVDDAALVVSELVTNAMRYGGGEFEFRLTLAEG
                     QVVIAVTDSCTRPPKLSLVGPDSETGRGLLIVAALADMWGVSPDGRTTWCSLSPRGES"
     gene            8064..8504
                     /locus_tag="RVR_RS08425"
                     /old_locus_tag="RVR_2389"
     CDS             8064..8504
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040050.3"
                     /locus_tag="RVR_RS08425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2389"
                     /product="DUF6302 family protein"
                     /protein_id="WP_202233255.1"
                     /transl_table=11
                     /translation="MNAAAGILPRLVPAYLAYDFEHFARLLADPELLRGAVGVRVHRAP
                     LLAVPIGGTRLGGSMSIDLIVLAEKVHDLLLGLRGFPDLRVLPSPYRSGGQVVEWGARP
                     PSSPHDDAARSRFYGYSEAAIERRAELAARRSSSTVPQRSPR"
     gene            8537..8725
                     /locus_tag="RVR_RS08430"
                     /old_locus_tag="RVR_2390"
     CDS             8537..8725
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019059383.1"
                     /locus_tag="RVR_RS08430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2390"
                     /product="DUF5999 family protein"
                     /protein_id="WP_202233256.1"
                     /transl_table=11
                     /translation="MCRHQPPCPDAQAPDREAAAVTARAFVQGWSLLCNGVLIFEDTGA
                     LLPTSEVIEPHARAISA"
     gene            8722..9441
                     /locus_tag="RVR_RS08435"
                     /old_locus_tag="RVR_2391"
     CDS             8722..9441
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS08435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_2391"
                     /product="hypothetical protein"
                     /protein_id="WP_202233257.1"
                     /transl_table=11
                     /translation="MSGPEWAVPYIVMRDGEEPVPETMISIRYGRGGKPVGLCYRDEMT
                     GDRDDRGVLWARTSQNRSLDNRLVGKPYFAKMHPARQRETMSMLRCQVCHAPASRTEHG
                     YLFVARKPAPGTEVEGMLTGQPPVCLPHAVAAIERCSFLAEQGYVLLRSRVPRLYGVLA
                     ATYGIRDDHALAPLPTPIGPNGEDAPVPYTRRDVTPWLLASQLVRRLTDVTTVDIDREL
                     ADHTVTAGPVEARGRHA"
     misc_feature    complement(9509..9522)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.68"
                     /tool="antismash"
     gene            9751..9921
                     /locus_tag="RVR_RS08440"
                     /old_locus_tag="RVR_2392"
     CDS             9751..9921
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016825826.1"
                     /locus_tag="RVR_RS08440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2392"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_202233258.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.1e-11, bitscore:
                     43.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQKVSTSITRTEEQPPSDGFDLNVSLLEVSDAASLTSLTDDNCG
                     STCGACTTNVA"
     CDS_motif       9751..9858
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTQKVSTSITRTEEQPPSDGFDLNVSLLEVSDAASL"
                     /locus_tag="RVR_RS08440_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9859..9921
                     /prepeptide="core"
                     /locus_tag="RVR_RS08440_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-7.70"
                     /molecular_weight="1807.9"
                     /monoisotopic_mass="1806.7"
                     /core_sequence="TSLTDDNCGSTCGACTTNVA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTQKVSTSITRTEEQPPSDGFDLNVSLLEVSDAASL"
                     /leader_location="[9750:9858](+)"
                     /alternative_weights="1825.9"
                     /alternative_weights="1843.9"
                     /alternative_weights="1862.0"
                     /alternative_weights="1880.0"
     gene            10001..13090
                     /locus_tag="RVR_RS08445"
                     /old_locus_tag="RVR_2394"
     CDS             10001..13090
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612044.1"
                     /locus_tag="RVR_RS08445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2394"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_237404639.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.2e-193,
                     bitscore: 643.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1e-17,
                     bitscore: 63.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.5e-21, bitscore:
                     76.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRPSFQASVTALVRAVARPAVAQLPWPDFDDRSFKAEELTDVTT
                     GRLTWIGSVWRSPNIVQALRHASPVLAHETEALIRAAAPSPRDVRRVGLSVARYLLRTL
                     RPTPFGLFAGVASAAFGTDPRARWGEDHAVVARAGAEWLAKLIEQLERSGELLPLLSVV
                     SNNTAFERDGSLVVPYQDDGPAGRRRVVEASVDLSPPVRSVLRAAGAPVRVGQLAEKLA
                     AEFPAVAPERVHGLLAGLVRRRVLITNLHAPATETDALRHLIAQLDAVGAGSIPLLADT
                     VRELRAVHAGLEQGGTAETRDDVAARMREVVPGLRRHPLALDLRLQADVVLPDVVAREV
                     ERAAAVLTRVCARPYGTEAWTEYHRRFYERFGIGTMVPLLEVVADSGVGYPDGYPGAAA
                     GARRRRLSPRDDVLVRLAQAAALDGRDEVVLTDEILAALERGPQEPRVPAHLEVGVRLH
                     AASLGEARRGQFTVEVTSVSRGAGVSTGRFLNVLEPDQRELLQGELADLPTADVGTVAA
                     QLSFPPLLPDTAHVTRTPRVLPLVVSLQEHRAPDSAVLTPSDLAVACDGRRMYLAAPGL
                     GVRIEATGMHALNLAEHTPPLARLITEVARAQSAQVTVFDWGAAAAMPFLPRLRHGRIV
                     LAPARWRLEADDFPDRRRPGGEWSAALTGWWERRRLPQHVHLVEDDRRLPLDLDQAGHR
                     SLLRQHLDRTRTAVLAEAGSPEANGWSGGRAHEIVVPLKAVQPPAWPALPTPTTARTLS
                     PAQLQPPATSPLLLAALYGDPRRQDSILSRHVPDLMRRLGSPQWWFIRFRDPAQHLRLR
                     ITLHDPDGFADTARTVSAWADELRSAGLLSDLRYPTSYREMGRWGSGPAWNAAEAVFNA
                     DSRALVAQLGQPVRPGQRSLAAAHFFAIASAFLGSPNAGARWLIDHIPATAPEQVPRPQ
                     FKESVTLADPSGDWAALRSSPGGTTIVDAWAERTAALAAYRPHLLGPHTEGIDVDDVLT
                     SLLHTHFVRHVAVNFPEEELCLYLARAAALAFTARARRRP"
     aSDomain        10484..10759
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_RVR_RS08445_Lanthipeptide_LanB_RRE.1"
                     /evalue="4.10E-20"
                     /identifier="RREFam001.1"
                     /label="RVR_RS08445"
                     /locus_tag="RVR_RS08445"
                     /protein_end="253"
                     /protein_start="161"
                     /score="63.3"
                     /tool="antismash"
                     /translation="VVSNNTAFERDGSLVVPYQDDGPAGRRRVVEASVDLSPPVRSVLR
                     AAGAPVRVGQLAEKLAAEFPAVAPERVHGLLAGLVRRRVLITNLHAP"
     misc_feature    11498..11500
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13087..14355
                     /locus_tag="RVR_RS08450"
                     /old_locus_tag="RVR_2395"
     CDS             13087..14355
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143557.1"
                     /locus_tag="RVR_RS08450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2395"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_202233259.1"
                     /sec_met_domain="LANC_like (E-value: 6.7e-42, bitscore:
                     142.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRSAHAVATAVANRLADPARAPAAATANASRQHLAFGPTGIAL
                     LHIERAAAGLGPWQRAHDWLAAATRQPFTSGPDSHPFYGAPALAHALACAADHLPGSYR
                     RSLSLLDQQMTADTRRRLDAAHRRIDTGQLPALREFDALRGLAGYGTYLLRRDPTGPVT
                     RAILDYCVRLTEPITRGIEHLPGWWAPTGPSGRPDGQFPGGHANHGMAHGVGAVLALLA
                     LSARRGTTVTGHHPAMRAILAWLEKWKTTSGRGTAWPYWITRDELRSGQLPASVPRRPS
                     WCYGTAGLARAQQLAALALADTDLQREAEAALLNALTDPAQLRATTDSGLCHGIAGLIH
                     LTARTAADAAPATADQFRAIIPALLAVLLPLGTAPDEAATRLLEDEAGAGLLDGAAGTA
                     LGLLAIDSSAPPHTAWDACLLTA"
     gene            14379..16445
                     /gene="fxlM"
                     /locus_tag="RVR_RS08455"
                     /old_locus_tag="RVR_2396"
     CDS             14379..16445
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010352620.1"
                     /locus_tag="RVR_RS08455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2396"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_202233260.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.1e-26, bitscore:
                     90.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 5.6e-42, bitscore: 142.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGWQQHNITFPDRDTARLAITDRLAPALIAAEDDGQLSGWWFMNK
                     QPWPLRYVADRPSPTVGALLDDLVADGTARSCTLGIYEPETEAFGGAGAMRAAHNLFHE
                     DSHHLLNYRDERGHLGRSETAVLLMSSLMRAASLDWFEQGDVWAKVAELRPGTLAPERS
                     AALVPAMHTLMTTEAHSLCRPGGPLDGRAEWVAAFERAGTTLAYLAAHGDLTRGLRAVI
                     AHHVIFHLNRAGLPSDDQHALSDIARKAVMGTSDTPTSGPETGSAADSVSAVNTDTLTD
                     PEADAEQLRTALVDQIRTDGRARVPAVEAALRAVPRHLFVPNASLADAYANAPVNIKYD
                     TNGTSISCASQPLVVALMLDQLEAQSGERILELGAGTGYNAALLGHLVGPTGHVTTIDV
                     DDDLVEGTRAHLAAAGVTNVEALTRDGALGHAEGGPYDRIIATVGAHGIPHAWLDQLAD
                     GGRLVTPQRLTGSVSRSIVYQKREGRWLSLGSEMNTFMPLRRGIADDDRRVVPLSADGT
                     VRLQAPAGQAIDADALAGVLDQPRVEEWSGMTVRAMESPEWMELFVSCSMPSGLIRMLF
                     PQTAKGTVLTADPYPSATAAVEKGAVTYLARRLSEQKTPEGDRLWEFGVIGHGPGSDEL
                     AVTVADAIRTWDRDYRSREAVFEILPVDGPAVEQRPGVFVLDTPLNRILVTWQ"
     gene            16531..17673
                     /locus_tag="RVR_RS08460"
                     /old_locus_tag="RVR_2397"
     CDS             16531..17673
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006347623.1"
                     /locus_tag="RVR_RS08460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2397"
                     /product="hypothetical protein"
                     /protein_id="WP_202233261.1"
                     /transl_table=11
                     /translation="MDPHGPIAQRFPLISRFRPACLPLPRRVHSLVELADAAAARVDQG
                     LASAVYNQAALLASDLGLPALAREMCCQHAAAYLHVVPLPGMTAIRALEPVVNLARLQI
                     RAGSKDDGRHHLLILYNAVTTGASAQVEGVHVPAGLTFNHTDRHEVRSWLWRVILADGT
                     RTLTTAGRWAEALAHIEEHRGVGQRMLDGRQVAVLATLCRNPTDAAALVAETTPGDPWE
                     NAVTSCLHVMCDRSLHRPVNSLLDALVDDYVEQQPNPGAGTTVFDTRLDLTILDLLDPR
                     QDEAAHQMTEELHRRTITTADGYAARECLATPRFASHLTLGQDRAIRELVHACALQRGS
                     LPELRTAQITKALRISDEVIRKTVTGPQGQPGATTTKPDA"
     misc_feature    17536..17538
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            <18324..18716
                     /locus_tag="RVR_RS08470"
                     /old_locus_tag="RVR_2398"
                     /pseudo=""
     CDS             <18324..18716
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013001053.1"
                     /locus_tag="RVR_RS08470"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2398"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="ALASRFSVQIQVGTDYDLALALKIDARVVRIARHLAAQVELGELG
                     WAPQLRELLSYQKAEAVLGTRAALANLIGIAPVEDRDAVAAAAGKIAGVRQVAPLTLGR
                     QLPAASTSAARQPPGSTGPAPWGRSR"
     gene            18713..20515
                     /locus_tag="RVR_RS08475"
                     /old_locus_tag="RVR_2399"
                     /pseudo=""
     CDS             18713..20515
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998572.1"
                     /locus_tag="RVR_RS08475"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2399"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSAHHHVQSSATAPDDDADLARWDDDGAPPARPRSSPAAWLRVGA
                     ELGDRLVALSGRQDLLVTCRPGTRSGAPAAYFPRLAEIEFDARLFAPLQPHEVRPRIVG
                     DEERYPAAWGVLVHEAAHAAHSVWEQPADADPRVVEAALLLEESRVEGAHLIRRPTDRT
                     YLRTSARTLVMPDIAHPALQGVEHAAGVAALILGRRDAGILDAGETKAVADLCEKVLGA
                     DLLATLTGIWTKAHRCADHDATTMLAHARDWCDALDTAGPALPAAPEDLTDLLAGAVAV
                     VMDTMAANDTADLAAQAASNNALAAQSRDKAQDRAQQAGQRRKAAATAKSVFNPRGTTV
                     SPDGAPRPSSNPITGTRRPTAAEQSAAARLSRALRAAAYRERTEEQATSPTPPGRLNMR
                     QALARDAQRAAGSIPTAEPFTHTRRRNSPTPPLRVGIAVDVSGSMSAACGPVASAAWIV
                     ARAAALTDPDSRTATIAYDMHLTALTRPTHRAPDRVTTFNAKGGKHNLGDAIDALDRGL
                     DLSRPGTGRLLVIVTDAKYTSDETAQALTRVKRLTTAGCAVLQLTLTA"
     gene            21082..>21327
                     /locus_tag="RVR_RS08480"
                     /old_locus_tag="RVR_2402"
                     /pseudo=""
     CDS             21082..>21327
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029007.1"
                     /locus_tag="RVR_RS08480"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2402"
                     /product="transposase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFSGLLPLVVEDVADEGERIVMRARTPQEAVVCPVCGALTGRVHG
                     YYWRTVADVPVDGRRVVVRVRVRRLVCPTLGCRQTFR"
     gene            complement(21484..23820)
                     /locus_tag="RVR_RS08485"
                     /old_locus_tag="RVR_2403"
     CDS             complement(21484..23820)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018560435.1"
                     /locus_tag="RVR_RS08485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2403"
                     /product="ABC transporter permease"
                     /protein_id="WP_202233262.1"
                     /transl_table=11
                     /translation="MRAVLRWALADLRTHLGQAVTIVLAGAGVTMALLISVAFLVVAAH
                     PWQRLFTATHGAHVWMRVHPGADTSALRRLDTVTDIAGPYRTISVSVQHGANKATVGLR
                     ASTSKPPTVGRPEIVAGRWPAADFGTAAPTGASAGSGVPVVLERSVAAALWAEPGDDIT
                     ARVDGTTVRLTVAALADTAEPHYSPGSYPGIGWAPKAFVDATASRTGGGTQTVGLVTSA
                     PGDTRYLVQQAVAAVGPDTVISVSTWRDARADAEDDSHLLGVFTGLFGLGALLAAAVAA
                     TGGIGVRVRAHARDVSILKAIGMAPRQVAGTFLLQHLVLVGGGVLTGVTAIETLGTRMP
                     GSIGQAMTVWRELPSQGWSVSLICAATLLVICSGAAMAGWRAARLPAIPMARRAVPPSG
                     RLSWGARTLLRWRVPPPLVLGWRATAIRPGRTAMAVLRITIPLLLISTVLGTWATLDAV
                     QHHPSHYGLTGQLSARASTDPGAVQKLLIGAPGVVQARPEIELAALAPGQTGTVALRGI
                     GTAAHPYPFAVVQGRAPAGLDEAVAGQGLFTALDVSVGQWIRLTVGSTPYILHLVGRNI
                     ETANSGLVVSTGFDILQDQAPSLRPASYNLQLRPGVNPDAERVALAAASRGAVEIDRVN
                     DPLTAEFSPMRRVIVGLILLLGLVVLTELSTTTASVVRDHAVDLRAYRAAGLTPRQIVA
                     AMSISTTLPALAAAFAGAALGVLASHRLVDLEGASSGIGAGIAHSASPVVLLLLVGATS
                     LVAALACVPASIRAVRHAATRPAEL"
     gene            complement(23826..24602)
                     /locus_tag="RVR_RS08490"
                     /old_locus_tag="RVR_2404"
     CDS             complement(23826..24602)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606981.1"
                     /locus_tag="RVR_RS08490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2404"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_202233263.1"
                     /transl_table=11
                     /translation="MRRNGASRQDAPQGGHLLVAEELVKSHRVNGAAVKAVRGIDLVVE
                     TGEFVAVTGPSGAGKSTLLHLLGGLQRPDSGRILLGGRRVDQLSEARWAALRRRRVGIV
                     FQFFNLVSTLTVADNVELPGLLAGRPGRDVRSERAGLLDELGLTGKEDSTPSDLSGGQQ
                     QRVALARALINRPNLLLADEPTGSLDSRGTREVLGLLSRCHQRGQTIVLVTHDAGVASA
                     ADRVVSLFDGRVADDVRFPDPPTRPGAVSAVVRLTG"
     gene            complement(24599..25105)
                     /locus_tag="RVR_RS08495"
                     /old_locus_tag="RVR_2405"
     CDS             complement(24599..25105)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849425.1"
                     /locus_tag="RVR_RS08495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2405"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_202233264.1"
                     /transl_table=11
                     /translation="MRFALLALLAKGPAHGYELKQAFEARLGAAYPQLNIGQVYVTLTR
                     LEKAGLIRGQDVEQSGRPNKRTYELTPAGHEAVAAWLEEPSEEPRVRDEFFMKLALARD
                     TGMADPIGLINKQRRHYLNLMRAMSRLAGVDEPGNPYPRLLVDGAVLHLQADLDWLEKC
                     QEELE"
     misc_feature    complement(26204..26219)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.6"
                     /tool="antismash"
ORIGIN
        1 tgagctgtgg gagttgttgt gcgggaccct gttcgtgctg cacaccggca tccagtggga
       61 gcgcctgccg caggaactcc ctcgctcgtc gaccggggct atccaggctc gaaacaccac
      121 ctgattgccg acggccacgg ggcacaccca tcggcatcat cctcgccgac ggtatccgcg
      181 acgacgttac ccagctgcta ccgctgatcg acgcgatccc ggccaccatc cgcctcgatc
      241 cgccggtccc acacaggacg ccggaccggg cgactggggt caggacgggc gggggaagac
      301 agacgcgagg gacgctcatc atcgctgacg cagcccgtgc gatcccgcac acgctgtggg
      361 cgctctccag cgagaacgag acggtcactg aactgaaggt tctcgttggg ttcgctggcc
      421 tggccgacga gaccacctag ggcctgtctc ctcgatcatg aacgtagcca gatgaggagg
      481 ttagcggcgg tgactgaacc gagatagacg tatccgcgtt tgtcgtagcg agttgcgaca
      541 gctctgaact gtttgatctt gtcgatcgcg cgctcgacgg cgttgcgggc ctggtacctg
      601 gtggggtcga agccgggtgg gcgaccgccg cgtgaacctc gccgtaatcg ggcagactcg
      661 gtgtcggact tttccgggat gctgtgccgg attccgcggc gacggaggta agcgcggatc
      721 agactgtgct gtatgccctg tcggcactga cagtgtccgg cagtcttcgc ggccggccta
      781 agggttgtcc cgtaactgcc gtccgcgggt gggatgatct tggtgtggct ggtgtgctca
      841 cggcgtcgga gtcgtcctgg atagccccgt tcactgggct gagcccgcgc gccttcggga
      901 agctggtgac agtgttgcgg cgcgagggtg cggacgcggt ccgcaagggt cggccgtggg
      961 gccttccgct ggaggaccgg gctctgctgg tcgcggcgta ctggcgcacg aacctgacga
     1021 tgcggcagct cgccccgctg ttcggggtgt cgaagtctgc ggcggaccgg atcatcgatc
     1081 acctcgggcc gatgctcgcg ctccagcccc gcaagcggtt cgcgaaggac gccgtgctca
     1141 tcgtggacgg caccctggtc cccacccgcg accacacggt ggccgagccg tcgaagaact
     1201 accggtactc caccaaccat caggtcgtca tcgacgccga cacccgcctg gtcgtcgtgg
     1261 tcggccggcc gctcgccgga aaccgcaacg actgcaaggc atgggaggag tccggtgcca
     1321 aagccgctgt cggcaacacg ctgacgatct ccgacggcgg ctacccgggc accggactcg
     1381 tcatgcccca ccgccgacgc aacggcgaag acctgcccga gtggaagcag gcgcacaaca
     1441 cgtcccacaa gcaggtccgc gcccgcgtcg agcacgtctt cgctcgcatg aagacctgga
     1501 agatcctccg agactgccgc ctcaagggcg acggcgtcca ccacgccatg ctcggcatcg
     1561 cccggatgca caacctcgcc ctcgccggat aggccagcga gccgtacgtc agcccgccct
     1621 acccgaaacg actcgaagat catttacggg acggccctta gacgagtagt tccgatgtct
     1681 cgggatccgc ggtttcggcc ccgggcagca ggaagggtgt tcagcatcgg gttgtgacga
     1741 ccgaaaaact gaacaccctt ctgacggcac tgtacgtgct ggtcgatgat catctgccga
     1801 aaactcggcg gctgggccgt cctccacgcc tgtccgacgc ggaactcgtg tgcctggccg
     1861 ttgcccaggt actgctcggc ttccactccg aggcccgctg gatccgcttc gcccacgccc
     1921 acctgcggcc gatgttcccc ggcctgcccc aacgcccggc ctacaacaaa cgcctccgcg
     1981 cagcccgacc acacatacag caggcaatcc gcaccctggc ccagcacagc gacctgtggc
     2041 ccgacccggt atggatcacc gactccaccc ccgtggagtg cggccgctcc cgcgacaccg
     2101 cccgccgctc cgccctggcc ggatgggccg gctacggcta ctgcgcctcc cactcccgct
     2161 ggttttgggg actgcgcctg cacctggtct gcacacccgc cggactgccc atcacctggg
     2221 ccctggccac cccgaaagtc gacgagcgag aggtcctggc cgcactgatc gagaccgaac
     2281 ccgacctggc ccacgaccgg cccggcctgc tgatcctcgc cgacaagggc tacgtctccg
     2341 ccgaactgga ccgcttcctg gaccagtacg gcatcaccct cctgcggccc tcctaccgca
     2401 accaccagcc ccgacccgga caaaccctcc tcaaaccgat ccggcaactg atcgaatcgg
     2461 tcaacgacac cctcaagggc caactcggcc tcgaacagca cggcggccgc accatcgagg
     2521 gcgccgctac ccgggtcagc cagcggatcc tcgcaatgac ctgcgcaatc tggcacaacc
     2581 gcaccaccgg ccaacccatc acccactcac tgatcgccta cgaccactga acaacccaca
     2641 tcggaacaac tcatctaggt cgaggcgagg gacacggatc ttgtccatga cggcctcgaa
     2701 ttgagtgcag tccgcccgct gtccggacgt gatgatcagt gagagcggcc ggcacttgcc
     2761 gtctgcgctc agatggatct tggtagtgaa cccgccgcgc gaacgcccga gtgcttcgtg
     2821 cagcatgccg gtctgcgggt gccccttttc gctgcttgca cagaccggca tggccggggc
     2881 tccggcagcg tgctggtggg cgcggatgga ggtggggtcg atgttgatgt cccagtcgat
     2941 accgcctccg gcgtcggcga cggcctgcac gtgctggagc agtcgttccc aggtgccgtc
     3001 ggcggaccac agcatgtggc gcttgtggat ggtctgccac gggccgtagc gggcgggcag
     3061 ctgacgccat tggcaaccag tgccaagccg gtggatgatc ccgttgatca cttggcggtg
     3121 atctctccac cggccgcagc agccggtact cgtggggagc agtggctcca gcacgctcca
     3181 ttcgtcatcg gtgagatccc ccctgctgag aacgccgtca gctcctctgt tcaggcagcg
     3241 tcgatgtctg ctgcgagctg gtcggccacg gtccgcggtt cgcggccgag gagttcgccg
     3301 agcagggggc cgactccggc gaagcggccc tcgcgggcgg cctggaaggt ggtgagcgtc
     3361 atccgggcca tggcttcggg agtaccggcg gccaccttgg ctgcaatcca cgcctcgtcg
     3421 tccagcacga tgcgctcgac ctcacggccg gtggtcttcg aggccagggc ggcgacatcg
     3481 tcgaaggtga cggcctggcg ggcagtgagg gtgaccgggc cgccgaaggc ccggccaccg
     3541 gtgaggatgg ccgccgcggc ttcggcggca tccgagcggt cggtccagga gacggggccg
     3601 tcggccgggg cggtgatggt gccgctctgc tgccagtcgc ccagcagcca gcccaggctg
     3661 tgggcgtaga agccgttgcg cagcgcggtc caggcgacgc cggagttggc gaggcactgt
     3721 tcggtggcgg cgtggtcgcg ggcggggtgg aaggggctgt ccactccagc gccctggtgg
     3781 ctggtgtaga ggatgcgccg ggcgcctgcg gcgacggcgg cgtcgatgcc gacgcggtgc
     3841 agggcgacag cgtcggcgtg cgggtcgttg gaggacacga gcaggacctg ctcggcgccc
     3901 tcgaaggagt gccgcagtgc ggccgggtcc tcgtaggagc ccttgcgcac ccgcaccccg
     3961 cggtcggcga agtgccgcgc cttggcggtg ttgcggacgc tgaccccgat ctgctcggcg
     4021 ggcatgcgct tgaggaggtg ctcgacggtg gcgccgttga gcgcgccggt cgcaccggtg
     4081 atgacgatca tgggattcct ttcattgccg cccgcgtgct caacgcacgc ggtgcgggct
     4141 tgggtcagcg gctgcgcagg agcggcagca ggatgtcgtc gaccaggtgc gcgacgaacg
     4201 gcccgtcgca cggctcgccc gcgatcatga tgcggtgcac gatgacggcc ggggcgatct
     4261 cggcgaacag cgccggggct ccgggggcca gatgttcccc gtgccggatc gccttgcgca
     4321 gcggctcgtc ggtcatcgcg gcctcgtcac ggcgcaggat gcgccgcatc tcctccgcga
     4381 gccgtacatc actgcgcatg ccggcgaaca gcgccccgag caggccgatc tcctgctcgg
     4441 cgatctgccg ggccaaccag gagaccaggc tgagcaggtt ctcccggaga tcgtccgaga
     4501 cgggctcggg aggcgtggct tgggcgcggt gctcgacggc tgcggccacg agcgcggcct
     4561 tatcgcggta ccggcggtag atcgtggtct tcgctgatcc ggaccggctc gcgaccgcct
     4621 ccatcgacag ctgctcgtag cccacctcgg acagcagcga cagtgtcgcc tccaagatgg
     4681 ccaggccgcg gccggtgtcg cgcggcctcc ccatcgccga ccgggcgtcg gcgcctcgga
     4741 cctgcgggcc acctggttcg cttcccactc cagttaccac tttcgctacg ctacggttgc
     4801 gtatcgaaag taactcgtaa cgcagccagc ggcaactcga accgctatgg ccgcgtgaca
     4861 gtgatcgagg agacaggccc taggtcgcga accggctgca cggcatgctc gtcctagctc
     4921 catccgttat cggcacgaat gctgggcctg agggttccgg cattcgtgcc caggtactca
     4981 gggccggcag gcggcggctg gccagtcgcg ttcacacccg gcaggcggta tggagtccgg
     5041 agcggagcgc cgaactacgc gacatgagct tcgaacgcgc ctggaatctg cagccaggcg
     5101 gataccgacg gcagccaaga actccacgac agaaggtgga ccatgtatgg agccgaccac
     5161 cttcgtctcc ctaacgagct cgtgcatggt tggcggtggc gcgtcgagac cttgatcgtt
     5221 gatcatgttc tggtggtggg gaaccgggct cgtgcagcga tcatccgtag ccagcggatc
     5281 acagggctga cgccggctgt gattaccgaa ctcgtcgcga agattggtcc gttgtggcac
     5341 gagcgccacc ggacggtact cgctgcgcgt cctcggcgca gggccgtggg cgccggggcc
     5401 aagcacaaac tggtcttcgt ggaccggctg ctggccacgc tggtgcacct gcggcacggc
     5461 gtcacgcacg acgtgctggc ctcctggttc ggcgttgacc gctcgaccat tacgcgtgcg
     5521 atcggtgaag tgcgcccgtt gctggccgaa cgcggctgca ccgtcgccac cggccagcgg
     5581 ctgcgcaccg tcgccgacgt catcgactac ctcggcgccg aagggcgcac cgggatcatc
     5641 gacggcaccg agatccgggt gcgccgcccg gccgccgggc gcaaggaccg ggagaagttc
     5701 atctccggga agaccaagca gaacgccgtg aagtccatgg tcgtcacgga cgccgaggga
     5761 cggctgctgt tctgcagccc ggccgagccg gccagctgcg cagacatcac acacgcccgg
     5821 aagttgggcc tggtcaagct cctgtccgac ggccctccag tggagatctt ggccgacgcc
     5881 gggtaccagg ggctggggcg cccagacggg cggtcgtgtg gtgacgcccc cgcaccggaa
     5941 gttcaagaag aacccgcccg ggtggtacga ggagatgcac gaacgccagc gcaaggccca
     6001 ctcctcacgg cgcatccggg tcgaacacgg gatcggccac ctcaagaact ggcgatccct
     6061 cgctcgacac cacggccgcc gcgagcacat gagcgacatc atccaagccg tcgccgggct
     6121 gctctcccac caacaagctg ccacgacggc gagccgtacg cgaacgtgaa ccctacggcc
     6181 cctctgcggc ctgcgacgcg ccaccgccaa ccatgcacga gctcgttagg atcatctcag
     6241 gcgggccacc caggcgcttc tagctgtcga actgccgcgt gttcaccttc gccaggaact
     6301 cggtgaaggc tgccggggtg aacagcagcg ccggtccgtt cggatccttc gagtcacgga
     6361 tggcgatgcc gcggcgggtc tgcgccacct cgacgcactg ctcgccaccg ttgctgaagg
     6421 acgacttccg ccacttggcg ttgggcaggt ccgtcgcgta cagctctatc ttctggttgg
     6481 gattcacgcc ccggttcctt ccatgatgtc cttgatcttc gctcgcgagt cgtccacgga
     6541 gagcgctgaa gccaccacgc gctcgaaggc gttctcgaac gccttcacgt cgtcggtgcc
     6601 ttcgacgaag gatccgccgc ggaggttctc caggttgacg accgtcggcc acggcgccgg
     6661 gaagcggacg acctcgaaga ggccgagcat cccggggtgc gccgtggcgt gtaggtccat
     6721 cacctgaatc gtgacgttgg gtagttcggt catgtccagc aggtgtcgca actggtcctt
     6781 catcagcgtc ggttgggacg ccgaccgtag gccgagggcc gcctcgtgga taacggccca
     6841 cagcttgagc ggcccttccg ccctggtggt gaggatagct tggcgcgtct tgcgcacctc
     6901 ggccagcgcg gtgacctcgg cggccgtccg cgtgatggcg gtggcggcga tgatctcgcg
     6961 cgcgtacgca ccggtctgca gcaggccggg gatgaggctc ggggtgtaga cgtgcacgct
     7021 ctcggcatcg gactccaggg tcaggtagtc cgtgtagctg agcgggacga catcgccgta
     7081 cgtctgccac cagccctgct tgccggcgtc ccgggcaagg ctctccagcg cggcgacggc
     7141 atcgacatcc tcaacgccgt acgccttgag gagcgctgcg acgtctcccg gtggcatccg
     7201 cgccctcgcg ttctcgatcc ggctgatctt gctctcgtcc catcccatcg cggcgccggc
     7261 cacctccccg ctgagggacg ccgccaagcg gtaggcccgc agggcatttc caaggcgccg
     7321 gcggcggagg gtcggaactg ctctcacgtt cggcatcggg tgtcggacgc tcccttcagg
     7381 gtgagctagg ggcatgtgca ggtgcatttt ggcaccccct ggtgcacaag tcgacggacc
     7441 gcatatgcca acttctgcca actcgggttc caagcttgca gattcgaggt ccagaaagtc
     7501 agactcgaca ggcaagccgc ggcaatgacc cacacgtacg gcagaccgag aagttcacca
     7561 agctgtggag gactgggcat gacgacgtac cgaagcacgg tcgactcgcc cctggtgaac
     7621 gcatccccgg cgccgactgt cccagcctcc gagcacgtcc gcgacgagat ggtccttcgg
     7681 ataccggacc gacctgctga agcgacgccc gaccacgctc cgcacggtcg gtgggtcggc
     7741 ctgctgcgcc acatcaccgc tgcgaaggcg cgccagtggg cactgtcgtc actggtcgac
     7801 gacgccgccc tcgtggtcag cgagctggtc accaacgcga tgcgatacgg cggcggcgag
     7861 ttcgagttcc gcctcacgct cgccgaggga caggtcgtca tcgcggtaac cgacagctgc
     7921 acccgtcctc cgaaactcag ccttgtcggc cccgacagcg agacaggtcg cggcctcctc
     7981 atcgtggcgg cacttgccga catgtggggt gtcagtccgg acggtaggac cacgtggtgc
     8041 tccctcagcc ctcggggaga gtcgtgaacg ccgcggccgg catcctcccg cgtctggtac
     8101 ccgcctacct ggcctacgac ttcgagcact tcgcccgtct gctcgccgat cccgagctgc
     8161 tccgtggcgc cgttggcgtc cgcgtccacc gggcgccgct tctggcggtg cccatcggcg
     8221 gtacgcgcct gggtggatcg atgtccatcg acctgatcgt tctcgcggaa aaggtgcacg
     8281 atctcctgct gggcctgcgg ggctttccgg acctgcgcgt cctcccctcg ccctaccggt
     8341 cgggcggtca agtggtcgag tggggcgcac ggccgccgtc cagcccccac gacgacgcgg
     8401 cgcgaagccg gttctacgga tacagcgagg cagccatcga gcgtcgcgcc gagctggccg
     8461 cgcggcgttc gtcctccacg gtgccccagc ggtcacctcg ttgatcctct gtctctttcc
     8521 gaaaggacaa ggccccatgt gccgacacca gccgccctgc cccgatgcgc aagctcccga
     8581 ccgtgaagcc gccgcggtca cggcgcgcgc cttcgtccag ggctggagcc tgttgtgcaa
     8641 cggtgtgctg atcttcgagg acaccggtgc cctgctgccg accagcgagg tcatcgaacc
     8701 gcacgcgcgg gcgatctcgg catgagcggg ccggagtggg cagtcccgta catcgtgatg
     8761 cgtgatggtg aagagcccgt gccggagacg atgatcagca tccggtacgg ccgcggaggt
     8821 aagccggtcg ggctgtgcta ccgggacgag atgaccgggg acagggacga ccgtggcgtg
     8881 ctgtgggcgc gcacgtcaca gaaccggtcg ctcgacaacc gactcgtggg gaagccgtac
     8941 ttcgcgaaga tgcaccctgc acggcagcgg gagacgatgt cgatgctgcg ctgccaggtg
     9001 tgccacgctc cggcgtcgcg caccgagcac ggctacctct tcgtggcgag gaaacccgcc
     9061 cccggaaccg aggttgaagg catgctgacc ggccagcccc cggtgtgcct gccacacgcc
     9121 gtcgcggcga tcgagcggtg cagcttcctc gccgagcagg gctacgtgct cctgcggtcg
     9181 agagtcccgc ggttgtacgg cgtgctggca gcaacgtacg ggatccgtga cgaccacgcc
     9241 ctggcgccgc tgccgacgcc gatcggtccg aacggtgagg atgcccccgt cccctacacc
     9301 aggcgcgacg tcactccgtg gttgctcgcc tcccaactcg tgcgccgcct gaccgatgtc
     9361 acgaccgtcg acatcgaccg cgaactggcc gatcacaccg ttacggccgg tccggtagag
     9421 gcacgaggaa ggcacgcatg atcctcgttt ccttcgaccg ctctgacgag ttgactgggc
     9481 tgctccctgt cgaactgcgc gcactgtctc acgccgcgtt atcagcgtcg cgcggcgcat
     9541 gcgtgtcgga cacgtcatca gggagccagg ttgatggcgc ccatgctgac cctggcacga
     9601 catcggacca gctcgcgttc cacctccaag atcttcccag ctcgtccacc gacctgggat
     9661 ggccagggtt gacccgaggc gcgccatagc agcgttccgg cggccagctc cggcaggcac
     9721 cacctgtcca ccacatcaac tggagttgcc atgacgcaaa aggtcagcac gagcatcacc
     9781 cggactgagg agcagccccc gtcggacggg ttcgacttga acgtctcgct gctggaagtc
     9841 tccgacgccg cgagcctgac cagcctgacc gacgacaact gcggcagcac ctgcggcgcc
     9901 tgcacgacca acgtcgcctg actcagctct gaacggcggt gtcggcgcgc tggctggcgt
     9961 ggcgacaccg cctccccatc cctggtgccc ggaggtacat gtgacacgcc cgtcgttcca
    10021 ggccagcgtg accgccctgg tgcgtgccgt cgcccgcccg gctgtggctc agcttccctg
    10081 gccggacttc gatgaccggt ccttcaaggc cgaggaactg acggacgtca ccaccgggcg
    10141 cctcacctgg atcggcagcg tctggcgcag cccgaacatc gtgcaggcgc tgcgccatgc
    10201 cagcccggtc ctcgcccacg aaaccgaggc cctgatcagg gccgctgccc catccccgcg
    10261 cgatgttcgc cgcgtcgggc tgtcggtggc gcgctatctg ctgcgcacgc tgcggcccac
    10321 gccgttcggg ctgttcgccg gggtggcctc agccgctttc ggcaccgatc cgcgcgcccg
    10381 ctggggcgag gaccacgcgg tcgtggcccg cgccggggcg gagtggctgg cgaagctgat
    10441 cgagcagttg gagaggagcg gggaactgct gccgctcctg tcggtcgtca gcaacaacac
    10501 ggccttcgag cgtgacggga gcctcgttgt tccctatcag gacgatggcc cggccggtcg
    10561 ccgccgcgtt gtcgaggcat ccgtcgacct gtcgccgccg gtgcggagtg ttctgcgcgc
    10621 ggccggcgcg ccggtccggg tcgggcaact ggccgagaag ctggcggccg agttcccggc
    10681 cgtggcgccc gagcgcgtcc atggactgct ggcgggcctg gttcggcggc gtgttctgat
    10741 caccaacctc cacgcgccgg ctaccgagac cgacgcactc cgccacctca tcgcgcagct
    10801 cgacgcggtc ggcgccggat ccatccccct cctcgcggac acggttcggg aacttcgcgc
    10861 tgtccacgcc gggctggagc agggcggcac cgcggagacg cgggacgacg tggcggcgcg
    10921 gatgcgagaa gtggtgccgg ggcttcgccg tcacccgctc gccctcgacc tgcgtctgca
    10981 ggccgacgtg gtacttccgg acgtggttgc ccgcgaggtg gagcgcgccg ctgccgtcct
    11041 cacccgggtc tgtgcccgcc cgtacggcac ggaggcgtgg accgagtacc acaggcggtt
    11101 ctacgagcgg ttcggtatcg gcacgatggt gccgctgctg gaggtcgtcg cggacagcgg
    11161 cgtcggctac cccgacgggt acccgggcgc cgcggcgggc gcgcgccgcc ggcgcctgtc
    11221 gccccgggac gacgtcctgg tccggctcgc ccaagccgcg gcactcgacg gccgcgacga
    11281 ggtcgtgctg accgatgaga tcctggccgc cctggagagg ggaccgcagg agccgcgggt
    11341 gccggcccac ctggaggttg gcgtacggct gcacgcggcc agcctcgggg aggccagacg
    11401 tgggcagttc accgtggagg tcacgagcgt ttcccgcggg gccggagtgt ccaccggccg
    11461 cttcctcaac gtcctggagc cagaccaacg cgaactgtta cagggcgagt tggctgacct
    11521 tcccaccgcc gacgtgggca ccgtagcagc acagctttcc ttccccccgc tgctgcccga
    11581 caccgcccac gtcacccgga ctccgcgcgt gctgccgctg gtggtcagcc tgcaagagca
    11641 ccgggccccc gactctgcgg tgctcacgcc gtcggatctg gcggtggcct gcgacgggcg
    11701 ccggatgtac ctggctgctc ccggcctcgg ggtacgcatt gaggctaccg ggatgcacgc
    11761 gctgaacctc gccgagcaca ccccgccctt ggctcggctt atcacggagg tggcacgggc
    11821 ccagagcgcc caggtcacgg ttttcgactg gggcgccgcc gcggcgatgc cgttcctacc
    11881 gcgcctgcgg cacggccgca tcgtgctggc cccggcccgc tggcggctgg aagcggacga
    11941 tttccccgac cgccgccgtc ccggcgggga gtggagcgcg gcactgaccg gctggtggga
    12001 gcgcaggcgg ctcccacagc acgtacacct ggtcgaggac gaccggcgac tgccgctcga
    12061 cctcgaccag gccggccacc gcagcctgct gcgccaacac ctcgaccgca cccgaacggc
    12121 agtcctagcg gaagccggct cgcccgaagc gaacggctgg agcggaggcc gggcgcacga
    12181 gatcgtggtg cccctcaagg cggtccagcc tccggcctgg ccagcgctgc ccacaccgac
    12241 cactgcccgc acgctgtccc cggcccagct ccagccgccg gcgacctcac cgttgctgct
    12301 cgccgccctg tacggcgacc cgcgacgcca ggattcgatc ctttcccgcc acgtgcccga
    12361 cctgatgcgg cgtctcggct cgccgcagtg gtggttcatc cgtttccgcg accccgccca
    12421 gcacctgcgc ctgcgcatca cgttgcacga cccggacggc ttcgccgaca ccgcccgcac
    12481 cgtcagcgcg tgggcggacg agctgcgctc cgccgggctg ctgtcggacc tgcggtaccc
    12541 cacctcctac cgtgagatgg gccggtgggg ctccggcccg gcctggaatg cggccgaggc
    12601 cgtgttcaac gcggactccc gagccctggt ggcacagctc gggcagcccg tccggccggg
    12661 gcagcgctcg ctggcggccg cgcacttctt cgccatcgcc tccgcgttcc tcggcagccc
    12721 gaacgccggg gcacgctggc tgatcgacca catccccgcc accgcgcccg aacaggtccc
    12781 ccgtccgcag ttcaaggaga gcgtcacgct ggcggatccg agcggcgact gggcggccct
    12841 gcggtcgtcg ccgggcggaa cgacgatcgt ggacgcctgg gccgagcgca ccgccgcgct
    12901 tgccgcctac cggccgcacc tgctggggcc gcacaccgag ggcatcgacg tggacgacgt
    12961 gctgacctcc ctactccaca cgcacttcgt gcggcacgtc gctgtgaact tccccgagga
    13021 agagctctgc ctgtacctcg cccgtgccgc tgccctggcc ttcaccgccc gcgcccggag
    13081 acgaccgtga ccgaccgctc cgcgcacgcc gtggcgaccg ccgtagccaa ccgcctcgcc
    13141 gacccagctc gggcgccggc ggcggccacc gccaacgcca gcaggcagca tctcgccttc
    13201 ggtccgaccg gcatcgccct gctgcacatc gagcgtgccg ccgctggact cggcccgtgg
    13261 cagcgcgccc acgactggct ggccgccgcg acccgacagc ccttcaccag cggacccgac
    13321 agccacccct tctacggagc cccggcgctc gcccacgccc tggcctgcgc cgccgaccac
    13381 ctccccggct cctaccggcg cagcctcagc ctgctggacc agcagatgac cgcagacacc
    13441 cggcgacggc tggacgccgc gcaccgccgc atcgacaccg ggcagctccc ggccctccgt
    13501 gagttcgacg cccttcgggg acttgccggc tacggcacct acctcctgcg ccgagaccca
    13561 accggcccgg tgacgcgggc catcctcgac tactgcgtgc gcctgaccga gccgattacc
    13621 cgcggcattg agcacctgcc gggctggtgg gcaccgaccg ggccatccgg ccgaccggac
    13681 ggccaattcc ccggcgggca cgccaaccac ggcatggcgc acggtgtcgg cgcggtcctc
    13741 gcgctgctcg cgctcagcgc ccgccggggc accaccgtca ccggccacca cccggcgatg
    13801 cgcgccatcc tcgcctggct ggagaagtgg aagacgacca gcggacgcgg cacagcctgg
    13861 ccgtactgga tcacccgcga cgaactgcgc tccggccagc tcccagcgtc cgtgccccgg
    13921 cgaccaagct ggtgctacgg caccgcggga ctggctcgcg cccagcagct cgccgcgctc
    13981 gccctcgccg acaccgacct ccagagggaa gcggaggccg ccttgctgaa cgcgctcacc
    14041 gaccccgcgc agcttcgcgc caccacggac agcggcctgt gccacggcat cgcaggtctg
    14101 atccacctca ccgcccgcac cgctgccgat gcagccccgg ccaccgccga ccagttccgc
    14161 gccatcatcc ccgcccttct cgccgtgctg ctccctctag gaactgctcc ggacgaggcg
    14221 gccacccggc tcttggagga cgaggcaggt gccggcctgc tcgacggcgc cgccggaact
    14281 gcgctcggac tactcgccat cgacagctcg gccccacccc acaccgcctg ggatgcctgc
    14341 ctgctcaccg cctgaaccgc cgaccgaagg acacctctat gggctggcaa cagcacaaca
    14401 tcaccttccc cgaccgggat accgcgcggc tcgccatcac cgaccgcctc gccccggcac
    14461 tgatcgctgc cgaagacgac gggcagctca gcggctggtg gttcatgaac aagcagccct
    14521 ggcccctgcg gtacgtcgcc gatcgcccct cgccgaccgt gggagccctg ctggacgacc
    14581 tggtcgccga cggcaccgcg cggtcctgca cgctcgggat ctacgagccg gagaccgagg
    14641 cgttcggcgg cgcgggagcc atgagggccg cacacaacct cttccacgag gacagccacc
    14701 acctcctcaa ctatcgggat gaacgagggc acttgggacg cagtgagacc gccgtactgc
    14761 tgatgagcag tctgatgcgc gccgcgagcc ttgactggtt cgagcagggc gacgtgtggg
    14821 cgaaggtcgc cgaactgcgc cccggcaccc tcgcgcccga gcgctccgcc gcgctcgtcc
    14881 cggcgatgca caccctgatg accaccgagg cccacagcct gtgccgcccg ggtggtccgc
    14941 tcgacgggcg cgccgaatgg gtcgccgcct tcgagcgcgc cggaaccacc ctcgcgtacc
    15001 tggccgccca cggtgacctg acccgcgggc tgcgcgccgt catcgcgcac cacgtgattt
    15061 tccacctcaa ccgcgccggt ctgccgtccg acgaccagca cgccctgtcc gacatcgcac
    15121 gaaaggcagt catgggaacg agtgacaccc ccacgtcagg accagaaaca ggctccgcgg
    15181 ccgatagcgt cagcgctgtg aacaccgaca cactcaccga tcccgaggcc gacgccgaac
    15241 agctccgcac cgccctggtg gaccagattc ggaccgacgg ccgcgcccgc gtccctgcgg
    15301 tcgaagcggc cctgcgtgcc gtcccgcggc acctgttcgt ccccaacgcc tcgctggccg
    15361 acgcctacgc caacgcgccg gtcaacatca agtacgacac caacggcacg tcgatctcct
    15421 gcgcctccca gcccctcgtc gtcgcgctca tgcttgacca actcgaagcc cagtccgggg
    15481 agcgcatcct cgaactcggc gccgggaccg gctacaacgc cgccctgctc ggtcacctcg
    15541 tcgggccaac cggccacgtc accaccatcg acgtcgatga cgacctggtc gaaggcaccc
    15601 gtgcccacct cgccgccgcc ggcgtcacca acgtcgaggc gctgacccgc gacggcgccc
    15661 tgggccacgc cgaaggcggc ccgtacgacc ggatcatcgc caccgtcggc gcgcacggca
    15721 tcccccacgc ctggctcgac caactcgccg atggcgggcg cctcgtcacc ccgcagcggc
    15781 tcaccggcag cgtgtcgcgc tccatcgtct accagaagcg cgagggccgt tggctctcgc
    15841 tcggctcgga gatgaacacg ttcatgccgc tgcgccgggg catcgccgac gacgaccgcc
    15901 gcgtcgtccc cctcagcgcg gacggcaccg tacgcctcca ggcaccggcc ggacaggcca
    15961 tcgatgccga cgcccttgcc ggtgtcctgg accagccgcg cgtcgaggag tggagcggga
    16021 tgacggtccg cgccatggag agccccgagt ggatggagct gttcgtctcc tgctccatgc
    16081 ccagcggcct gatccggatg ctcttcccgc agaccgccaa aggcacggtg ctcaccgccg
    16141 acccctaccc ctcggccaca gccgccgtcg agaagggagc ggtcacctac ctcgcccgcc
    16201 gcctctccga gcagaagacc cccgagggcg accggctctg ggagttcggc gtcatcggcc
    16261 acggtcccgg cagcgacgag ctggccgtca cggtcgccga cgccatccgc acctgggacc
    16321 gcgactaccg cagtcgcgag gccgtcttcg agatcctgcc ggtcgacggc cccgcggtcg
    16381 agcagcggcc tggtgtcttc gtcctcgaca cccccttgaa ccgcatcctc gtcacctggc
    16441 agtagccacg gccgtggggt gctcgccggt cggcgaacac cccacgcggc cccgtatgct
    16501 ccgcgtcttc ctcatctccc ggggaacctc atggacccgc acggacccat agcccagcgc
    16561 tttccgctca tctcccgatt ccggcctgcc tgcctgcccc tccctcggcg cgttcacagc
    16621 ctggtcgaac tcgccgacgc cgcagccgcc cgggtggacc agggcctcgc atccgccgtc
    16681 tacaaccagg ccgcgctcct tgcctccgac ctcggactgc cggccctcgc ccgggagatg
    16741 tgctgccaac acgccgctgc ctacctccac gtagttcccc tgccggggat gactgcgatc
    16801 cgcgccctcg aacccgtcgt gaacctcgcg cgactacaga tccgcgcagg cagcaaggac
    16861 gacggtcgac accacctgct catcctctac aacgcggtca ccaccggcgc cagcgctcaa
    16921 gtcgagggcg tccacgtgcc ggccggcctc accttcaacc acaccgaccg ccacgaggtg
    16981 aggtcttggc tgtggcgcgt catcctggcc gacgggaccc gcaccctgac cacggccggc
    17041 cgctgggcag aggctctggc gcacattgag gagcaccgag gagtcgggca gcgtatgctc
    17101 gacggccgcc aggtcgccgt cctcgccacg ctctgccgaa accccaccga cgccgccgcg
    17161 ctcgtcgccg agacgacgcc cggtgacccc tgggagaacg ccgtcaccag ttgcctccac
    17221 gtgatgtgcg accgttccct gcaccggccc gtcaactctc tccttgacgc gttggtggac
    17281 gactacgtcg agcagcaacc caaccccggt gccggcacca ccgtcttcga cactcggctc
    17341 gacctcacga tcctcgacct tctcgacccg cgccaggacg aagcggctca ccagatgacc
    17401 gaggaactgc accggcgaac catcacgacg gccgacggct acgccgcccg cgagtgcctg
    17461 gccacacccc gcttcgcatc ccacctcaca ctgggtcagg accgagcgat ccgcgaactc
    17521 gtccacgcat gcgcattaca gcgcggtagc ctccccgaac ttcggactgc acagatcaca
    17581 aaggccctac gcatcagcga cgaagtcatc cggaagaccg tcactggccc gcaagggcaa
    17641 ccaggagcga cgactacgaa acctgacgcg taaagccgca tctggaagag acgatcaccc
    17701 ggcgcggagt cgccttgccc caggaaggcg cacagtgcgc gcctggtggg gacgttgtga
    17761 cgtaggaggt gagtcggact gcctccacgc ggcgcgacgg ccgaggaccg cgagtaccgt
    17821 tctgaatgtc taggtcagaa cggagcccag catgccgtac cccgcagacg ccgcgggagg
    17881 cgtccccggc gaccgactca aagccgcccg cctccgccgc ggtctcaccc aagaagcact
    17941 cgccgaacgg gccggcctga gcctgggcgt catcaagaag ctggaacgtg gcggaatcgg
    18001 ccgcctggag acttaccacg cgctcgcccg agccctccac gtgcgcacct ccgcgctctt
    18061 cgactcgccc gggccgcacg agtcgcgccg caacgacggc gacaacatcg ggctcatggc
    18121 cttgcgtcaa gccatcacgc cgccgatcac cctgaccgga cgtctccgac cacctgccag
    18181 tggcgacacc gagcccgacg tcgaccagct cgccgcgaca gcccgcaccg tcgccgccgc
    18241 ctaccaccgg gacgactacc gaaccgtcgc agaactcctc ccgcctctcg tgctgtccgc
    18301 gcacgaggtc gtcgaccacg taggcgctcg cgagccggtt cagcgtgcag atccaggtcg
    18361 gcacggacta cgacctcgcc ctggctttga agatcgatgc ccgggtcgtc cggatcgccc
    18421 gacacctcgc cgcccaagtc gaactcggcg agctgggctg ggccccgcag ctgcgggaac
    18481 tgctcagtta ccagaaggcc gaggccgtcc tcggcaccag ggccgcgctc gcgaacctga
    18541 tcggaatcgc tcctgtggag gaccgcgacg ccgtcgccgc cgccgccggc aagatcgccg
    18601 gcgtcaggca ggtcgcgcct ctcaccctgg gccgacagct ccccgctgcg agcacgtcgg
    18661 ccgcccggca acccccgggc agcaccggcc ctgcgccctg gggccgctcg cgatgagcgc
    18721 ccatcaccac gtccagtcct ccgccaccgc gcccgacgac gacgccgacc tcgcacgttg
    18781 ggacgacgac ggcgccccgc ccgcacggcc ccgttcctcc ccggccgcgt ggctgcgtgt
    18841 gggagccgaa ctcggcgacc ggctggtcgc cctgtccggc cgccaggacc tgcttgtcac
    18901 ctgccgcccc ggcacccgca gcggcgcacc ggccgcctac ttcccccgcc tggcggagat
    18961 cgagttcgac gcccgcctgt tcgcacctct gcaaccccac gaggtccgcc cgcggatcgt
    19021 gggcgacgag gaacgctatc ccgccgcctg gggagtgctc gtccacgaag ccgcccacgc
    19081 cgcccactcc gtgtgggagc agccagccga cgcggacccg cgcgtcgtcg aggccgcgct
    19141 cctgctggag gagagccgcg tcgagggcgc ccatctgatc aggcggccca ccgaccgcac
    19201 gtacctgcgc accagcgccc ggaccctggt catgcccgac atcgcccacc ccgccctcca
    19261 gggcgtcgag cacgccgccg gcgtggcggc cctgatactc ggccgccggg acgccggcat
    19321 cctggacgcc ggcgagacca aagccgtcgc cgatctgtgc gaaaaagtcc tgggcgccga
    19381 cctgctggcc accctcaccg gcatctggac caaagcccac cggtgcgccg accacgacgc
    19441 caccaccatg ctcgcgcacg cccgggactg gtgcgacgcc ctggacaccg ccggccccgc
    19501 cctgcccgcc gcgccggaag acctcaccga tctgctggcc ggcgccgtgg ccgtcgtcat
    19561 ggacaccatg gccgccaacg acacggccga cctcgcggca caggctgcct cgaacaacgc
    19621 cctggcagcg cagtcccggg acaaggccca ggaccgcgcc caacaagccg gccaacggcg
    19681 caaggccgcc gccaccgcca agtcggtctt caacccgcgc ggcaccaccg tcagccccga
    19741 cggcgcaccg aggccctcca gcaacccgat caccggtacc cgccgaccca ccgccgccga
    19801 gcagagcgcc gccgcgcgcc tgagccgcgc gcttcgcgca gccgcctacc gagaacggac
    19861 cgaggaacag gccaccagcc cgaccccgcc cggccgcctc aacatgcgcc aagccctcgc
    19921 ccgcgacgcc cagcgcgccg ccggctcgat acccaccgcg gaaccgttca cccacacccg
    19981 ccgccgcaac tcccccaccc cgccgctgcg cgtgggcatc gccgtcgatg tctccggctc
    20041 catgtcggcc gcctgcggcc ccgtcgcgtc cgccgcctgg atcgtggccc gcgcagcggc
    20101 cctgaccgac cccgactccc gcaccgccac catcgcctac gacatgcatc tgaccgcact
    20161 gacccgaccc acccaccggg caccagaccg cgtgacgacg ttcaacgcca agggcggcaa
    20221 acacaacctc ggcgacgcca tcgacgcact cgaccgcggt ctcgacctca gccgccccgg
    20281 caccggccgc ctcctcgtga tcgtcaccga cgccaagtac accagcgacg aaaccgctca
    20341 ggccctcacc cgcgtcaaac gcctcaccac cgccggctgc gccgtacttc agctcaccct
    20401 caccgcataa tccctccacc tgccgggcac caccctgctc cacctgcccc agccctccag
    20461 cgcccccgcc gccatcgcca aggccgccac cgacgccatc cgcagaacac gctgaagcgc
    20521 cgtcacacga ccaccacacc cgtccgcgcc acccgctgac cgcgtaccgc cgccagacgg
    20581 gcctgcgccg cgcacgagag gcatcatctg caccatctca cccctactgg ggcccgtatt
    20641 cttgccgcac acgacaacgg cacggtcacc ggacaccccg ccgccctggc ctggctccac
    20701 gccgaccagc tgatcacgga ccgccaaccc ggcagcggcg cacgtcagat aacggacgcc
    20761 ggccgagcgg cgtacgaaca gtggaaggcc gactacggac cgcccgcgtc gccgtcctca
    20821 tccggcgtgc cgcccaggct ccccgcccgg cagcacgacg cggtcctcgc cgctgcccgc
    20881 cgccccgacc acctggttcc gggcatcgac gaccacgtac ccggcttctt caaccggcgg
    20941 accctggcag ccgtccacgg agtcggctac gccgacatcc gggtctgtca aacgagcggc
    21001 cctgtctcac tttcggtggt gacggagagt cgtgagggtc gttgactagg tgtggaggac
    21061 gtcaacgagc ttgtgcgggt ggtgttttcg ggtctgttgc cgctggtggt cgaggatgtg
    21121 gccgacgagg gtgagcggat cgtgatgagg gcgcggactc cgcaggaggc tgtggtctgt
    21181 ccggtgtgcg gggcgttgac ggggcgggtg cacggctact actggcggac cgtcgctgac
    21241 gtgccggtcg acggtcgccg agtggtggtc cgtgtgcggg tgcggcgtct ggtgtgtccc
    21301 acgctcggct gccggcagac cttccgtgct ttctcacgca ccaggcggca tcgctgccgg
    21361 acggtccgcg cgtggccggt ggcgcgtcac gtggctggtg ttccccttcc tctgacacat
    21421 gattcgagcc cggtgtagcg gccctggagg tgatgcacga tctccgggcg cggcctcctg
    21481 gtctcacaac tcggcgggtc tggtggccgc gtggcgcacc gcccggatcg acgctggcac
    21541 gcaggcgagc gcagccacca aactggtggc gcccacaagc aggagcagta ccacgggcga
    21601 ggcggagtga gcgataccag cgccgatacc gctgctagcg ccttcgaggt caacgagtcg
    21661 gtgtgaggcg aggacaccga gcgcagcccc ggcgaacgcc gccgcaaggg cgggaagcgt
    21721 cgtgctgatg ctcatggccg cgacgatctg ccgcggggtg agcccggcgg cgcggtaggc
    21781 ccgcaggtcg accgcgtggt cgcgtacgac agaggcagtg gtggtggaaa gctctgtcaa
    21841 gaccaccaag cccagtagga ggatcaagcc gacgatcacc cggcgcatcg gtgagaactc
    21901 tgccgtcagg gggtcgttga ccctgtcgat ctcaacggcg ccccggctcg ctgcggccag
    21961 cgccacacgc tcggcgtccg ggttgacccc aggacgcagt tgcaggttgt aggatgccgg
    22021 ccgcagtgag ggtgcctggt cctggaggat gtcaaatcct gtggacacga ccaggccgct
    22081 gttggccgtc tcgatgttcc gtccgacgag gtgcaggatg tagggggtgc tgccgacggt
    22141 cagacggatc cactgcccga ccgagacgtc gagtgcggtg aacaggcctt gaccagcaac
    22201 ggcctcgtcc agtccggcgg gtgcccggcc ctggaccacg gcgaacgggt acgggtgcgc
    22261 cgcagtgccg atgccgcgca gcgcgacggt cccggtctgt cctggggcga gtgcggcgag
    22321 ttcgatctca ggacgtgcct gaaccacgcc gggggcgccg atcagcaact tctgcactgc
    22381 gccgggatcg gtactcgcgc gagcgctgag ctgtccggtc aggccgtagt gcgacgggtg
    22441 gtgttgaacg gcgtccaggg tcgcccaggt gcccagcacc gtactgataa gcagcagagg
    22501 gatggtgatg cgcagaactg ccatcgcggt gcggcccgga cgaatggcgg tagcgcgcca
    22561 tccgagcacc aggggcggtg gcacccgcca ccgcaggagc gtgcgggcac cccaggaaag
    22621 acggccactg ggcggaaccg ccctgcgggc catggggatg gccggcagtc gtgccgcgcg
    22681 ccacccggcc atagccgcgc cggagcagat caccagcagc gtagccgcgc agatcagcga
    22741 caccgaccag ccttgggacg ggagctcccg ccaaaccgtc atggcctggc cgatagagcc
    22801 gggcatgcga gtgcccagcg tctcgatggc cgtgacaccc gtgaggaccc cgccgcccac
    22861 gaggacgagg tgctggagca ggaaggtgcc tgccacctgg cggggcgcca tgccgattgc
    22921 cttgaggatg gagacatccc gtgcgtgggc gcgtacccgc acgcctatgc caccggtcgc
    22981 ggcgaccgct gcggcaagca gcgcgcccag cccgaacaac ccggtgaaca cccccaacag
    23041 gtgactgtcg tcctccgcgt cagcccgcgc atcgcgccag gtggaaactg agatcacggt
    23101 gtccgggccg acggcggcga ccgcctgctg cacaagatag cgggtgtcgc cgggggcaga
    23161 ggtgaccagg ccgacagtct gtgtgccgcc acccgtgcgc gaggccgtgg cgtccacaaa
    23221 tgccttgggc gcccagccga tgcccgggta gcttcccggc gagtagtgcg gctcggcggt
    23281 gtccgcgagc gcggcgaccg tcaaccttac tgttgtgccg tctacgcggg cggtgatgtc
    23341 gtcgccgggc tcggcccaca gcgcggcggc gaccgaccgc tctaggacca ctggcacacc
    23401 ggagccggcc gaggctccgg tgggagccgc cgtgccgaag tcggcggccg gccacctgcc
    23461 cgcgacgatc tcgggccgac ctaccgtcgg cggcttggag gtggaagcgc gcaggcccac
    23521 cgttgccttg ttcgctccgt gctgcacgct gacggagatg gtgcggtagg ggcccgcgat
    23581 gtccgtgacg gtgtccagcc gtcgcagcgc ggaggtgtct gccccggggt gcacgcgcat
    23641 ccacacgtgg gccccgtgtg tggcggtgaa caagcgctgc caggggtggg cagcgacgac
    23701 caggaaggcg acggatatca ggagcgccat cgtgacgccg gcaccggcca gcacgatggt
    23761 gaccgcctgg ccgaggtgag tgcgcaggtc ggccagcgcc cagcgcagta cggcacgcac
    23821 ggcggtcagc cggtgagccg cacgaccgcg ctgacagcac cgggacgcgt cggcgggtcg
    23881 gggaagcgta cgtcgtcggc cacacggccg tcgaagaggc tcacgacgcg gtcggcggcg
    23941 ctggcaaccc cggcgtcgtg ggtgaccagt acgatggtct gccctcgctg gtggcagcgc
    24001 gaaagcaggc ccagcacctc tcgggtgcct ctgctgtcga ggctgccggt cggctcgtca
    24061 gcgagcagca agttcggacg gttgatcaac gcgcgggcga gggcgacacg ctgctgttgg
    24121 ccgccggaca ggtctgaggg agtgctgtcc tccttgccgg tgagccccag ttcgtcgagc
    24181 aacccggccc gctctgagcg gacgtcccgc ccgggacggc cggcgagaag gccgggcaat
    24241 tccacgttgt ccgccacggt gagggtggac accagattga agaactggaa gacgatgccg
    24301 acgcggcgac ggcgcagggc ggcccaccgc gcttcgctca actggtcgac gcgccgtccg
    24361 cccaacagaa tgcggccgct gtcgggacgc tgcaagccgc ccaagaggtg gagcagcgtg
    24421 gacttgccgg ctccggacgg accggtcacg gccacgaact caccggtctc gacgaccagg
    24481 tcgatgccgc ggacagcctt gaccgccgcc ccgttgaccc ggtggctctt gacaagctcc
    24541 tcggcaacaa gtagatgtcc gccttgtggg gcgtcctgcc gcgacgcgcc gttgcgtctc
    24601 actcgagttc ctcctgacac ttctccagcc agtccaggtc cgcctggaga tgcagcaccg
    24661 cgccgtcgac gagcaggcgc gggtaggggt tgccgggttc gtcgacaccg gccagacggg
    24721 acatggcccg catcaggttc aggtagtgcc tgcgctgctt gttgatcaaa ccgatagggt
    24781 ccgccatgcc agtgtccctt gcaagggcaa gtttcatgaa gaactcgtca cgtacccgtg
    24841 gttcctcgga cggctcttcc agccaggcgg ccacggcctc atggccggcg ggagtcagct
    24901 cgtaagtccg cttgttggga cgtcccgact gctcgacgtc ttgtccgcgg atcagcccgg
    24961 ccttctccag cctggtgagg gtgacgtaga cctggccgat gttcagttgg ggataggcgg
    25021 cgccgagacg ggcctcgaac gcctgcttca gctcgtagcc gtgcgccggg cccttggcga
    25081 ggagcgcgag aagcgcgaag cgcacctcgg atcggcctcc tcccgacctg ccggtccgtc
    25141 cagcaccaag ggtgatcggt tctgcgggac ggccgcggag aatgtacgaa tggaccgtag
    25201 catcgcaggc cgcccgccga tatacatgac gcgtaggtgg cgccgttcgg cgactcgaac
    25261 ggcaagggga ggcacgggat ggcgcagtca ggactcgcct gccggaccgg ccgggcgatc
    25321 gcagccgccc tgctgacact tctcgccggc tgcgccggcg gccggggcgg cggagactcc
    25381 ggcctcggtc cgatcacctt ggccaccggc cgggacctga ccggatacct ccagcatgtg
    25441 ctggacggtt ggaaccggtt gcaccccggt cagcgggtga cgctgattca gttgccggag
    25501 gcggccgacg agacttacgt gcagatggcc gacagtctgc gggcgggaag ctcccgtttc
    25561 gatgtcctga acctcgatgt cgcctggact tcggagtttg ccgccgcggg ttggatcgag
    25621 ccgctggacc gtggcaggct tccgctgtcc cacctccttc cgtcggtcac cagcaccgct
    25681 acctttcacg gtcagctata cgcgatgccc tacgtcacca acgcaggcct gctctactat
    25741 cgcaaggaca tcctcgccaa ggccggtgtg tctccgccgc gcacctgggc acagctgtcg
    25801 gacgacgcgc ggacgatcgc accgcgttac ggactgcagg gttacgcagg gcagttgctt
    25861 ccctacgagg gactgacggt caacgtcacc gaggcagtcc agtccgcagg cggcaccatc
    25921 ctgggcgacg aaggccgcac ggtcgacgtc gactccccgg ccgcgcgggc cggccttgcc
    25981 tttctggtcg acggcgtacg gcagggctgg attcccaagg ccgcgctgaa cttcaaggag
    26041 gaggagtccc ggcgcgactt ccaggccggt cacctgctgt tcctccgtaa ctggccctat
    26101 gtctacgacg aggcgaacgc ggccggttcg gcggtcgcgg gcaacgtcgg tgtggtcccg
    26161 ctgcctggtg agaacggacc cggcaccggc gtgctcggcg ggtccgacct ggcggtgaac
    26221 gtgcactccc gacacccgca gaccgccagg gaccttctgg cgtacctgtc cagcgaggga
    26281 gtgcagcggc aagtgctcac cgaggggtcg ctggcgccgg tatgggcttc cctctacagc
    26341 gacccagccc tcgtgcgccg ttacccgtac ctgccagtgc tcaagcagag tgtggactcg
    26401 gccgttccgc ggccgaagag cgcgcactac gaccaggtga gcctt
//
