LOCUS       NZ_AP018365            22277 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  Streptomyces sp. SN-593 chromosome.
ACCESSION   NZ_AP018365
VERSION     NZ_AP018365.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. SN-593
  ORGANISM  Streptomyces sp. SN-593
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Panthee,S., Kito,N., Hayashi,T., Shimizu,T., Ishikawa,J.,
            Hamamoto,H., Osada,H. and Takahashi,S.
  TITLE     beta-carboline chemical signals induce reveromycin production
            through a LuxR family regulator in Streptomyces sp. SN-593
  JOURNAL   Sci Rep 10 (1), 10230 (2020)
   PUBMED   32576869
  REMARK    DOI:10.1038/s41598-020-66974-y Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Takahashi,S., Toyoda,A., Sekiyama,Y., Takagi,H., Nogawa,T.,
            Uramoto,M., Suzuki,R., Koshino,H., Kumano,T., Panthee,S., Dairi,T.,
            Ishikawa,J., Ikeda,H., Sakaki,Y. and Osada,H.
  TITLE     Reveromycin A biosynthesis uses RevG and RevJ for stereospecific
            spiroacetal formation
  JOURNAL   Nat Chem Biol 7 (7), 461-468 (2011)
   PUBMED   21642985
  REMARK    Publication Status: Online-Only
REFERENCE   3
  AUTHORS   Panthee,S., Takahashi,S., Takagi,H., Nogawa,T., Oowada,E.,
            Uramoto,M. and Osada,H.
  TITLE     Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds
            from Streptomyces reveromyceticus SN-593
  JOURNAL   J. Antibiot. 64, 509-513 (2011)
REFERENCE   4
  AUTHORS   Takahashi,S., Takagi,H., Toyoda,A., Uramoto,M., Nogawa,T., Ueki,M.,
            Sakaki,Y. and Osada,H.
  TITLE     Biochemical characterization of a novel indole prenyltransferase
            from Streptomyces sp. SN-593
  JOURNAL   J Bacteriol 192 (11), 2839-2851 (2010)
   PUBMED   20348259
REFERENCE   5  (bases 1 to 8833490)
  AUTHORS   Takahashi,S., Ueki,M., Toyoda,A., Ishikawa,J., Sakaki,Y. and
            Osada,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2017) Contact:Shunji Takahashi Chemical Biology
            Research Group, RIKEN Center for Sustainable Resource Science
            (CSRS); Hirosawa 2-1, Wako, Saitama 351-0198, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Phrap v. 0.990329
            Genome Coverage                   :: 16x
            Sequencing Technology             :: ABI 3730
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016756395.1-RS_2024_05_21
            Annotation Date                   :: 05/21/2024 03:58:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,420
            CDSs (total)                      :: 7,334
            Genes (coding)                    :: 7,181
            CDSs (with protein)               :: 7,181
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 153
            CDSs (without protein)            :: 153
            Pseudo Genes (ambiguous residues) :: 0 of 153
            Pseudo Genes (frameshifted)       :: 35 of 153
            Pseudo Genes (incomplete)         :: 136 of 153
            Pseudo Genes (internal stop)      :: 8 of 153
            Pseudo Genes (multiple problems)  :: 25 of 153
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:29:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1887694
            Orig. end                         :: 1909971
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP018365.1.
            This work was done in collaboration with Shunji Takahashi, Masashi
            Ueki, Atsushi Toyoda, Yoshiyuki Sakaki and Hiroyuki Osada (RIKEN)
            and Jun Ishikawa (National Institute of Infectious Diseases).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22277
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="13"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22277
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22277
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12277](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12277
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(262..276)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.68"
                     /tool="antismash"
     gene            635..2344
                     /locus_tag="RVR_RS07880"
                     /old_locus_tag="RVR_2235"
     CDS             635..2344
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009718651.1"
                     /locus_tag="RVR_RS07880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2235"
                     /product="DUF58 domain-containing protein"
                     /protein_id="WP_202233165.1"
                     /transl_table=11
                     /translation="MGSPAGPVPPPPGSRPPGAAPTAPPQPAGPYPGPHPGPYAAPPPG
                     PYTAQQAQGPYTGRPAPGPHAGSYAPPGSYAPPGPYTAQQAQGPYAGQQRPPGGAGAGP
                     ADERPPGGFRRALGGLTTRGRSFVAAGVAAAACSYVLGQSDLLRVGLLLAALPLVCVAV
                     LYRTRYRVAGSRRLAPSRVPAMSEARVHLRVDNVSRMHTGLLMLQDRVPYVLGPRPRFV
                     LDRVEPGGHREVSYRVRSDLRGRYPLGPLQLRLTDPFGMVELTRSFSAFDTLTVVPRVE
                     PLPPVRLAGESSGYGESRTRALALAGDDDVIPRGYRHGDDLRRVHWRSTAKYGELMVRR
                     EEQPHRAHCTVLLDTRRDAYFGAGPDSAFEWAVSGAASVATHMLERGFAVRLLTDTGSS
                     VPGPEGSSGFGADSGDMAGLLLDTLAVVDHSDGDDLAGAYDVLRTGGEGLLVGFFGDLY
                     QEQAATIARMRQRAGGAVAFVLDSDDWLARELGGRPGPELSAVQPGADGGEPDSTERAV
                     RVLREAGWSVVEVRPGASLPELWQQADRYRSREQTQQQARAEQAPRGAGAAG"
     gene            2341..4734
                     /locus_tag="RVR_RS07885"
                     /old_locus_tag="RVR_2236"
     CDS             2341..4734
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060019.1"
                     /locus_tag="RVR_RS07885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2236"
                     /product="DUF3488 and transglutaminase-like
                     domain-containing protein"
                     /protein_id="WP_202233166.1"
                     /transl_table=11
                     /translation="MSGRARLTVCAVVASLLAAAALLPLTDSSTWYGKALLVVLLQAAV
                     GAGCRRVPLARPLTVLVQAVVSLVVLTVMFASQQALGGVLPGPQALQQLGQVVQQGITD
                     VSNYSIPAPVSPGIRMLLVGGVTIVALAVDAMAVTYNSAAPAGLPLLALYSVAAGLDSG
                     SAAWLYFLLAAAGYLLLLLAEGRDRMSRWGRVFSSAPPPGAWSGGQFGQPRPTPVRGAR
                     RIGVMALGIALIAPAALPSLGDGLLDTSGHGGSGLGGRGGSVNLIAALQDNLNQPSNSE
                     VLTYSTSAKPASDMYLRIAALDKFDGTQWVPSDLPTEALPTELPRPQGMAADVKYTTAT
                     TRVQVDDSYVQSMLPVPFPATSVRTTGDWKYQPEGRMLVGEHGQTAAGQRYTVTSMEVE
                     PTAQQLAQAPEATGRIAEQYEQVPSSLPAIVKQTALQETKGATNDYQKAVDLQNYFTSG
                     QFVYNTQAKAGTGVDAIARFLQTKEGFCVHFAFTMAAMARTLHIPARVAIGFTPGSPAA
                     DGDGLMTVGLKDAHAWPELYFEGIGWTRFEPTPYRGSAPDYTQSTTPTGGSGDQDVAPH
                     TSAPATTDTPAPTQSCAPGTTADGTGCSQAALPASGGSGGGFGGGRAALIALAALLVLL
                     LPTAPVLWRSRLRRRRLGGGDRVEGLALSAWREVVDTGWDYGIPPDGSETPRRAMARLV
                     RDGHLEGEPAESAARLATAVEQTLYAARPRPATGLADDVQRVRRGLKAGTNRRGRLRAA
                     LLPRSAARVGWALSARWAAFTGRTRAAVQRLAAPLRRRAAREAS"
     gene            complement(5192..5608)
                     /locus_tag="RVR_RS07890"
                     /old_locus_tag="RVR_2238"
     CDS             complement(5192..5608)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381431.1"
                     /locus_tag="RVR_RS07890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2238"
                     /product="DUF3040 domain-containing protein"
                     /protein_id="WP_202233167.1"
                     /transl_table=11
                     /translation="MPLSEHEQRMLEQMERALYAEDPKFASALEGNGVRAFTRRRVYLA
                     VLGFLCGIGLLMGGMVAQQSWLGVVGFLVMLACAVLAVTAWRRANRPPEAGPAAIPGHF
                     GRRFGARRRQQRRGKVMDRIEERWQRRRDQQQGQ"
     gene            complement(5856..6638)
                     /locus_tag="RVR_RS07895"
                     /old_locus_tag="RVR_2239"
     CDS             complement(5856..6638)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557098.1"
                     /locus_tag="RVR_RS07895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2239"
                     /product="methyltransferase"
                     /protein_id="WP_202233168.1"
                     /transl_table=11
                     /translation="MSRAGSRPGGVDPIRPRASLRTAVVWEVLQGALERRAKAADRPAL
                     DVLDTGGGTGNFAVPVARLGHRVTVVDPSPDALFALERRAAEAGVTDRVSAVQGDVHGL
                     LGVVRPGGYDMVLCHGVLEYVDDPAEGVRNVVDALRPAGSLSLLAAGRGGAVLARALAG
                     HFAEAQQALLDPDGRYGAADSLPRRFTADDLTRLVTEAGLRTASVHGVRVFADLVPGVL
                     VDTEPGAAEALLRLELAAAEDPGFHSVATQLHVLAERD"
     gene            complement(6758..7291)
                     /locus_tag="RVR_RS07900"
                     /old_locus_tag="RVR_2240"
     CDS             complement(6758..7291)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180433.1"
                     /locus_tag="RVR_RS07900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2240"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_237404631.1"
                     /transl_table=11
                     /translation="MALPAMPSMPPTPSVPPPPGSSGAPAGLGSPADIHPVLRRAGAAP
                     AALDLLAQARAGLAEAAHLDAPHERYATAHLAALRTAAAVLAVRGRPEQSPRKRARIRS
                     AWEVLPEVAPELGEWSALFAAGAERRARADAGIPAAAGPRDADDLLRAAGMFLRLVERM
                     LLLRPAPAGTVSDT"
     gene            7459..8082
                     /locus_tag="RVR_RS07905"
                     /old_locus_tag="RVR_2241"
     CDS             7459..8082
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141980.1"
                     /locus_tag="RVR_RS07905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2241"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_202233169.1"
                     /transl_table=11
                     /translation="MTSARRRATRRKLFEAAVTLIAEQGFSATTVDEIAERAGVAKGTV
                     YYNFASKNVLFEELLRHGVGLLTASLRRAADETAARGDSRVDALDAMIRSGLAFIVRYP
                     SFTQLYVAELWRTNRTWQDTLMAVRQEAVAVVEKVLGEAVERGEVSGEIDVPLTASALF
                     GMVLVAALDWQAFQPERSLDDVHETLSRLLQGRVGGSAAHRCAR"
     gene            8290..9813
                     /locus_tag="RVR_RS07910"
                     /old_locus_tag="RVR_2242"
     CDS             8290..9813
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576837.1"
                     /locus_tag="RVR_RS07910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2242"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_202233170.1"
                     /transl_table=11
                     /translation="MGRIAVVGAGMAAMAVAARLATGGHEVVVHERAETYGGAVGRYTR
                     DGFAFDTGPGLLVLPAVYRDLFVKTGREPLEECVGLAQVDPAGRHLFADGTGVSLPNAS
                     RSGVIGALDAAFGPGGGERWSDVLVRAREVWEGVRRPLLEEPAGDPGPLARDPYPGRRR
                     GLRRRPPYLAEVAADELGGDPRAAALLEWYALAYGLDPRTAPAAAAVLPYLEQSFGLWY
                     VRGGMRALADALHARCRARKVEFRFGSEVAGVEVRGGEVQGLRFTDGSTAAADVVAASV
                     PLPYLPQETLPAATGDPLTGARDEPGRCTVHVALRGSRPAGTAHRTVVHAADRGAALDW
                     VFGRGRAEVPAADALTVGVLRPDDPAGRPDDGHEAVTVTATVPRHATAGARHGAGRDWS
                     ADRFADAFAERMLQVAERAVPGLRERELWREVRTPLDVERETGAAGGSVPVPSLPGAGG
                     ALLRPPNRTALKGLYFLGGWAHPGGGLPHAGMSAAIVADLVAGGPGGSR"
     misc_feature    complement(9874..9894)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.24"
                     /tool="antismash"
     gene            10001..12277
                     /locus_tag="RVR_RS07915"
                     /old_locus_tag="RVR_2244"
     CDS             10001..12277
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014158016.1"
                     /locus_tag="RVR_RS07915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2244"
                     /product="germacradienol/geosmin synthase"
                     /protein_id="WP_202233171.1"
                     /sec_met_domain="T1TS (E-value: 5.2e-78, bitscore: 262.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQPFELPAFYVPYPARLNPHLERARGHSKDWARQMGMIEGSGIW
                     AESDFDSHDYALLCAYTHPDASGPELDLVTDWYVWVFFFDDHFLDIFKRTPDMAGAKAY
                     LDRLPAFMPVDLAQEVPEPANQVEAGLADLWRRTVPRMSHGYRRRFHESTRHLLEESLW
                     ELSNISTGRVSNPIEYIEMRRKVGGAPWSANLIEHAAGAEVPDAIAASRPMRVLRDCFA
                     DAVHLRNDLFSYQREIEDEGELSNAVLVLERFLDLAPQEAAEAVNDLLTSRLQQFEHTA
                     FTEVEPLFEEFGLDPAQRLAVFGYVKGLQDWQSGGHEWHLRSSRYMNGADDRARAVGVL
                     AGPNGIGTSAAQIAGSLAATLPQRARAYGHAPFQRVGWVRRAPVPMPFPTTLSPHLDAS
                     RAHNADWSGRMGLLDAEPGFPVPGGLWNGRKLAAYDFALCAAGIHPAASREELDLTTDW
                     LTWGTYGDDYYPLVFGRAGDMAAARITTERFKLFMPLDAGAVPPPLTALERSLADLWRR
                     TAGPMTPAERRRFRTSIEEMCESWLWELANQKLNRVPDPVDYIEMRRRTFGSDLTMSLS
                     RIGHGDALPDEVYRSRPVRGMEVAAQDFACLLNDVFSYRKEIEFEGEIHNAVLVVQNFL
                     DCGPQQAMDVVGDLMAARMAEFQHITETQLPTLLTEFDLDEKAGEVLLGYVQELRDWMA
                     GILTWHEGCARYTEETLLEHYPHVAAAPASRHPWATPSGLGLSAARLPALLGDRRGRPA
                     ADAGQ"
     gene            complement(12271..13335)
                     /locus_tag="RVR_RS07920"
                     /old_locus_tag="RVR_2246"
     CDS             complement(12271..13335)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018555507.1"
                     /locus_tag="RVR_RS07920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2246"
                     /product="hypothetical protein"
                     /protein_id="WP_202233172.1"
                     /transl_table=11
                     /translation="MGYSVLYIAFGIVALWLLGEVLLQYKARLRWRVLAFAGFLGLVVG
                     VAERSVVLILLGAVAFGTGQSMVTLSYKRGFSTGWSIGGRPGSSRRRRAAGTRPAEPVL
                     EVGPIEPDADDPAGPQQSAEELAGVGATAVHDFSALPGDGQDGYGAEQAVYQPMPMLDD
                     SGEYPLYDGQSTYTPDPYTSGGYEGYGAQGYQSWTGYEQQPSWEQGQHQGGQGGGYQEQ
                     PAAAAAAAASYGYDPDEYDVFGNSRGTEGSAFGGQDTGGGFGGQDTGGGFGGQDTGGGY
                     GGQDAGGDWRFPQPYPQQPAAEPYGGYGYDQQVYDQQQAYIPQQPHQPPYEQQHGQQPQ
                     QQEEYADPYDPYRY"
     gene            complement(13359..14279)
                     /gene="metF"
                     /locus_tag="RVR_RS07925"
                     /old_locus_tag="RVR_2248"
     CDS             complement(13359..14279)
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060028.1"
                     /locus_tag="RVR_RS07925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2248"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_202233173.1"
                     /transl_table=11
                     /translation="MALGTSSTRTDRATTIRELLASGHRSYSFEFAAPRTEKGERTLWN
                     AIRRIEAVRPTFVSVTYGAGGSSREGTVRATDRIVSDTTLTPCAHLTAVNHSVAELRNI
                     IGQYADAGIRNILAVRGDPPGDPMGEWVAHPQGLTYAAELVRLVKESGDFCVGVAAFTE
                     MHPRSTDPAEDTRHFLDKCRAGADFAITQMFFDPDAYLRLRDRVDRAGCTVPIIPEVMP
                     VTNVRQIERFSQLGNAPFPPDLAERLLAVQDDPAAVRAIGIEFTTEMCRRLLAEDIPGL
                     HFITLNHSTASLEIYENLGLHQQAA"
     gene            complement(14536..15201)
                     /gene="thiE"
                     /locus_tag="RVR_RS07930"
                     /old_locus_tag="RVR_2249"
     CDS             complement(14536..15201)
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141984.1"
                     /locus_tag="RVR_RS07930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2249"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_202233174.1"
                     /transl_table=11
                     /translation="MPTPTASARLADARLYLCTDARTTRGDLAAFADAALSGGVDVIQL
                     RDKGIEARQELAALDVLAEACERHGRLLAVNDRADVAHAAGADVLHLGQDDLPVPAARA
                     LLGPDVLIGRSCHAEAEVDAAAVEPGADYFCTGPVWPTPTKPGRPAPGLDLVRHAAALG
                     TPRPWFAIGGIDLGNLPEVLAAGARRIVVVRAITEAPDPYEAAAALARTIRRAEPSPA"
     gene            complement(15300..15674)
                     /locus_tag="RVR_RS07935"
                     /old_locus_tag="RVR_2250"
     CDS             complement(15300..15674)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906970.1"
                     /locus_tag="RVR_RS07935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2250"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_202233175.1"
                     /transl_table=11
                     /translation="MTVYSSVDARIDALVPSWLTLPEVAERLGLEVTRIRPLIKEGQLI
                     AVRRGENKVLMVPGDFIGDGKIVKGLPGTLTLLKDDGFTDDEALEWLFTPDPTLPGTPA
                     NALRENRGTEVKRRAQALAV"
     gene            complement(15787..16998)
                     /locus_tag="RVR_RS07940"
                     /old_locus_tag="RVR_2252"
     CDS             complement(15787..16998)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019885561.1"
                     /locus_tag="RVR_RS07940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2252"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_272933064.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 9.2e-58, bitscore:
                     194.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDERRAVIVGAGMAGVQTAVELRQQGWRGPVTLLGDEPHPPYDRP
                     PLSKAVLLGAEGGALADVRFDVDFRALGVELRLGVHAQALRAEQHHLVTDAGLVAYDAL
                     VLATGAYPVVLPGTAGLAGVHPLRTLDDAAALRPVLERREHVVVVGAGWIGAEFATAAR
                     QAGCEVTVVEAADRPLAGVLPASVTAHMTGWYGEAGVTLRTGTTVAGVEAGGVVLADGS
                     RLAAGAVVVGIGARPATGWLAGSGVTLDPQGAVRADERLRTTAPDVFAVGDCASFPSAR
                     YNRRLLVHHWDNAVQGPRTAAANLLGGEEAYDPVPYFWSEQFGRFVQYAGFHREEDTLI
                     SRGDPSDGSWSVLWLRRGVLVAVLAVGRPRDMAQARKLIAAGSAPDPVLAADPAVPLKS
                     AVPR"
     regulatory      17097..17209
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17166..17179)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            17206..18489
                     /gene="thiO"
                     /locus_tag="RVR_RS07945"
                     /old_locus_tag="RVR_2254"
     CDS             17206..18489
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576840.1"
                     /locus_tag="RVR_RS07945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2254"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_202233176.1"
                     /sec_met_domain="DAO (E-value: 2.3e-68, bitscore: 230.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTRTADVLVVGGGIIGLVTAWRAAQRGLSTVVADPSPGGGAAHV
                     AAGMLAAVTELQYGEQTLLDLNLASAARYPDLVAELASDTGMDAGYRPCGTLAVALDAD
                     DRADLRDLHAFQTSLGLAAQWLSGRECRRLEPLLAPGVRGGLRVDGDHQVDPRRLAAAL
                     LRAADAAGAEFVRAKAARLRCAGDRVTGAELADGTRVSAGRTVLAAGCESGRMPGLPQD
                     ALPPVRPVKGQILRLRMPAGQAPFLSRTVRAVVRGSHVYLVPRENGELVLGATSEEFGW
                     DTAVTAGGVYQLLRDAHDLVPGITELPLTETLAGLRPGSPDNAPLLGPSPLDGLLLATG
                     HHRNGVLLTPITGDVLGHVLDTGGLPDYAAPFAVGRFAAGAAGTGTAAPGAAGSGRPGT
                     PPGGTPPGATPPLGAGHVGASAREEQSV"
     gene            18486..18692
                     /gene="thiS"
                     /locus_tag="RVR_RS07950"
                     /old_locus_tag="RVR_2255"
     CDS             18486..18692
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557085.1"
                     /locus_tag="RVR_RS07950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2255"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_202233177.1"
                     /transl_table=11
                     /translation="MTITVLVNGERRALEDPVELGALVARFTSAPSGVAAALNETVVPR
                     SRWAATRLAEGDRVEILTAVQGG"
     gene            18749..19531
                     /locus_tag="RVR_RS07955"
                     /old_locus_tag="RVR_2256"
     CDS             18749..19531
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180423.1"
                     /locus_tag="RVR_RS07955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2256"
                     /product="thiazole synthase"
                     /protein_id="WP_272933137.1"
                     /transl_table=11
                     /translation="MRIGGVVFGSRLIMGTGGAPSLDVLEHALRASGTELTTVAMRRMD
                     PTAKGSVLSVLDRLGIRVLPNTAGCFTAGEAVLTARLAREALGTDWVKLEVIADERTLL
                     PDPVELLDAAETLVDDGFTVLPYTSDDPVLARKLEDVGCAAVMPLGSPIGSGLGIRNPH
                     NFQLIVEQASVPVVLDAGAGTASDAALAMELGCDAVMLASAVTRAQRPDLMAAAMRDAV
                     NAGRLAHRAGRIPRRYGALASSPVDGAASLGAPPVPRA"
     gene            19892..21883
                     /gene="pknB"
                     /locus_tag="RVR_RS07960"
                     /old_locus_tag="RVR_2257"
     CDS             19892..21883
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141990.1"
                     /locus_tag="RVR_RS07960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_2257"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_202233178.1"
                     /sec_met_domain="Pkinase (E-value: 5e-49, bitscore: 165.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTSVQDPLVGQVLDGRYLVEGRIAVGGMATVYRATDTRLDRELA
                     LKVMHPSLADDAVFVERFIREAKAVAKLAHPNVVGVFDQGTDGTYVYLAMEYVAGCTLR
                     DVLRERGALQVHAALDILEPVLAALGAAHRAGLVHRDMKPENVLIGDDGRVKVADFGLV
                     RVIDTKTSASTGAVLGTVSYLAPEQIGHGTVDQRADVYACGVVLYEMLAGRKPYDGDTP
                     VKVMYQHVNEDVPAPSAAVPTVPPLLDALVARACARPQQERPADAVELLAEVRTARAAL
                     SAEELDALPGGPAARPSGPVAVPGAEPSDTVPAAGTTGTAGTAGTPPPGSEEPTSVVAL
                     PEDALTDRTARLMPPAPAPDDPPAAPAAGWFRSRRGPLAVLVALLVVLGVGAGVWYIND
                     GQFTTVPGVLSLPQAKAEQKLDRAGLDSKVKQGFSLTVPRGSVIATDPSPGRRIRGNGT
                     VTLTVSKGPQHVRVPDVAGRDLATARKEIKEASLVPSTVTESFSDDVPRGRVVATDPAG
                     TTQLDPGTRVAITVSRGRPVDVPDVVGESVTDAQQDLEAAGLKVVLAPGKVFSDVADKD
                     KVALVSPGKGSQVARGDSVTITVSKGQQQFPVPDVTGKSSGDAKKILQAAGFDVRVINV
                     FFGSTVFSQSPDGGSQAPKGATITLWVR"
     misc_feature    22112..22126
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.53"
                     /tool="antismash"
ORIGIN
        1 tcgacggcac cacctacgaa ctgcccagcc ccttcatggt gatcgccacc cagaacccgg
       61 tggagatgga gggcacctac ccgctgcccg aggcgcagcg ggaccgcttc accgcccggg
      121 tctcgatcgg ctacccgagc cccgaggccg agctgaagat gctcgacgtg cacggcgggg
      181 tctccccgct ggacgacctc cagccggtcg cgcacgcgca cgacatcgtg aagctgatcg
      241 aggcggtccg gcaggtgcac gtcgccgatc cgatccgccg ctacgcggtg gccctcgtgg
      301 gcgccacccg cagccacccc gacctgcggc tgggcgcctc cccgcgcgcc accctgcacc
      361 tggtgcgggc cgcccgcgcc tccgcggccc tggacggccg cgagtacgtc ctgcccgacg
      421 acgtgcaggc gctggcctcc gcggtcctcg cgcaccggct gctgccgacc gcgcaggcgc
      481 agctcaaccg gcgcacgccg gagcaggtgg tggccgagat cgtgcagcgc gtgccggtgc
      541 cggacccggc cgcgggcggt gcggccggcg tcgccggctg gccgcagcgg ccggccggac
      601 agccccaggg catgccggac acgcggggcc tgtgatgggc tcgcccgccg gcccggtccc
      661 tcccccgccg ggctcccggc cgcccggggc ggctccgacc gcaccgccgc agcccgcggg
      721 accgtacccc ggaccgcacc cgggaccgta cgcggctccg ccgccggggc cgtacacggc
      781 gcagcaggcc caggggccgt acacgggccg gccggccccg gggccgcacg ccgggtcgta
      841 cgcgccgccc gggtcgtacg cgccgccggg gccgtacacg gcgcagcagg cccaggggcc
      901 gtacgcgggg cagcagcgac cgccgggcgg ggccggggcc gggcccgccg acgagcggcc
      961 gccgggcggc ttccgccggg cgctgggcgg cctgaccacg cgcggccggt cgttcgtcgc
     1021 cgccggggtg gccgcggccg cctgctccta cgtgctgggc cagtccgacc tgctgcgggt
     1081 cggactgctg ctggccgcgc tgccgctggt gtgcgtggcc gtgctgtacc gcacccgcta
     1141 ccgggtggcc ggcagccgcc ggctggcgcc ctcccgggtc ccggcgatgt ccgaggcccg
     1201 ggtgcacctg cgggtggaca acgtctcgcg gatgcacacc ggcctgctga tgctccagga
     1261 ccgggtgccc tacgtcctcg ggccgcggcc ccggttcgtg ctggaccggg tggagcccgg
     1321 cggccaccgc gaggtgtcct accgggtccg ctccgacctg cgcggccgct acccgctcgg
     1381 gccgctccag ctccggctga ccgacccctt cggcatggtc gagctgaccc ggtccttcag
     1441 cgccttcgac accctcaccg tggtgcccag ggtcgagccg ctgccgccgg tgcggctggc
     1501 cggcgagtcc tcgggatacg gcgagagccg cacccgggcg ctggcgctgg ccggcgacga
     1561 cgacgtgatc ccgcgcggct accggcacgg cgacgacctg cgccgggtgc actggcggtc
     1621 gaccgcgaag tacggcgagt tgatggtgcg ccgcgaggag cagccccacc gcgcgcactg
     1681 cacggtgctg ctggacaccc gccgggacgc ctacttcggc gccggacccg actccgcctt
     1741 cgagtgggcg gtgtccggcg ccgcgtcggt ggccacgcac atgctggagc gcggcttcgc
     1801 ggtgcggctg ctgaccgaca ccggcagcag cgtgccgggg cccgagggca gctccggctt
     1861 cggcgccgac tccggcgaca tggccgggct gctgctggac accctcgcgg tggtcgacca
     1921 ctccgacggc gacgacctgg ccggggccta cgacgtgctg cggaccggcg gcgagggcct
     1981 gctggtgggc ttcttcggcg acctctacca ggagcaggcg gccaccatcg cgcggatgcg
     2041 gcagcgggcc ggcggcgcgg tggcgttcgt gctggacagc gacgactggc tggcccgcga
     2101 gctgggcggg cgtcccggcc ccgaactgtc ggcggtgcag ccgggcgccg acggcgggga
     2161 gccggacagc accgaacgcg cggtgcgagt gctgcgcgag gcggggtgga gcgtggtgga
     2221 ggtgcggccg ggtgcctcac tgccggaact ctggcagcag gcggaccgtt accggtcacg
     2281 cgagcagacg cagcagcagg cgcgggccga gcaggcgccg cggggagcgg gagcggcggg
     2341 atgagcggac gcgcacggct cacggtgtgc gcggtggtgg cctccttgct ggccgccgcc
     2401 gcgttgctgc cgctgaccga cagcagcacc tggtacggca aggcgctgct ggtggtcctc
     2461 ctccaggcgg cggtgggtgc cggatgccgc cgggtgccgc tggccaggcc gctgacggtg
     2521 ctggtgcagg ccgtggtgtc gctggtcgtg ctcacggtga tgttcgcctc gcagcaggcc
     2581 ctcggcgggg tgctgcccgg tccgcaggcc ctccagcagc tcggacaggt ggtccagcag
     2641 ggcatcaccg acgtctcgaa ctactcgatc ccggcgccgg tcagccccgg catcaggatg
     2701 ctgctggtcg gcggcgtgac gatcgtggcg ctcgcggtcg acgcgatggc cgtgacctac
     2761 aacagcgcag ccccggccgg gctgccgctg ctcgcgctgt actccgtcgc cgccggtctg
     2821 gacagcggca gcgcggcatg gctgtacttc ctgctggccg ccgccggcta cctcctgctg
     2881 ctgctcgccg agggccggga ccggatgtcc cgctggggcc gggtgttcag cagcgcgccg
     2941 ccgcccggcg cgtggagcgg cggccagttc ggccagcccc ggcccactcc ggtgcgcggc
     3001 gcccggcgga tcggcgtgat ggcgctgggc atcgcgctga tcgcgcccgc agcgctgccc
     3061 tcgctcggcg acggcctgct ggacacctcc gggcacggcg gcagcgggct cggcggccgc
     3121 ggcggttcgg tcaacctgat cgccgccctc caggacaacc tgaaccagcc gagcaacagc
     3181 gaggtgctca cctacagcac cagcgcgaag cccgcctcgg acatgtacct gcggatcgcg
     3241 gcgctggaca agttcgacgg cacccagtgg gtgccctcgg acctgccgac cgaggccctg
     3301 ccgaccgagc tgccgcgccc gcaggggatg gccgccgacg tgaagtacac gaccgccacc
     3361 acccgggtcc aggtcgacga cagctacgtg cagagcatgc tgccggtgcc gttccccgcg
     3421 acgagcgtgc ggaccaccgg cgactggaag taccagcccg agggccggat gctcgtcggc
     3481 gagcacggcc agaccgccgc cggccagcgc tacaccgtga ccagcatgga ggtcgagccg
     3541 accgcccagc agctcgccca ggcccccgag gccaccggcc ggatcgccga gcagtacgaa
     3601 caggtgccca gctcgctgcc ggcgatcgtc aagcagaccg ccctgcagga gacgaagggc
     3661 gccacgaacg actaccagaa ggccgtcgac ctccagaact acttcacctc cggccagttc
     3721 gtgtacaaca cgcaggccaa ggcgggcacc ggggtggacg cgatcgcccg gttcctccag
     3781 acgaaggagg gcttctgcgt ccacttcgcc ttcaccatgg cggcgatggc ccgcaccctg
     3841 cacattccgg cccgggtcgc gatcggcttc acgcccggct cacccgccgc cgacggcgac
     3901 ggcctgatga cggtgggcct gaaggacgcg cacgcctggc ccgagctgta cttcgagggc
     3961 atcggctgga cccggttcga gccgacgccg taccgcggca gcgcgcccga ctacacgcag
     4021 agcacgacgc ccaccggcgg ctccggcgac caggacgtcg cgccgcacac ctcggcgccc
     4081 gccacgaccg acacgcccgc cccgacgcag agctgcgcgc cgggcaccac cgcggacggc
     4141 accggctgct cgcaggcggc gctgccggcg agcggcggat ccggcggcgg cttcggcggc
     4201 ggccgggcgg cgctgatcgc gctcgccgcg ctgctggtcc tgctgctgcc caccgcgccg
     4261 gtgctgtggc gctcgcggct gcgcagacgc cggctcggcg gcggggaccg ggtggaggga
     4321 ctcgcgctgt ccgcgtggcg ggaagtcgtc gacaccggct gggactacgg catcccgccc
     4381 gacggttcgg agacaccgcg ccgggcgatg gcccggctgg tgcgggacgg gcacctggag
     4441 ggcgagccgg ccgagtcggc ggcccggctc gccacggcgg tggagcagac gctctacgcc
     4501 gcgcggcccc ggccggccac cgggctcgcg gacgacgtcc agcgggtccg ccgggggctg
     4561 aaggcgggca cgaaccgccg cggccggctc cgggccgccc tgctgccgcg ctcggcggcc
     4621 agggtcggat gggcgctgtc cgcccgctgg gcggcgttca ccgggcgcac ccgggccgcc
     4681 gtgcagcggt tggccgcgcc gctgcgccgg agggcggcgc gggaggcgtc ctagggtcgg
     4741 tccggccgga cgcgtcaccg ccgcagcggg gcgagccgta cgagcctcag ggccgggccg
     4801 gcgcgccccg aggccggtgc cggccggggt ccgcgcaggg gcagggcggg ctggcgtccg
     4861 cgcaggtgcg gggcgggccg gcgtccgcgc agggccgggg ccgggtcgta cggcttcgag
     4921 agccggagtc cgcgtcgagg cgccgggacc ggccgcggac gtggtgcggg cggcccgcac
     4981 aggggcggcc gatcagcgcg ggacccggtc gtcacaccgc cggccggcgc ggcgcctggc
     5041 cgtcgtagga agccgagtcc tcaccgggtc ggctgtgcgg cgcaccgacg gcgcgggagg
     5101 ggacgggacg ggacgcgccc ggacctccgg agcccggaca ccgcgaggaa gggcgcggcc
     5161 cccaccgggg tcgcgccctt cctgcgacgg ctcactggcc ctgttgctgg tcgcggcggc
     5221 gctgccaccg ctcctcgatg cggtccatca ccttgccgcg gcgctgctgg cggcggcggg
     5281 ccccgaagcg gcgaccgaag tggccgggga tcgcggcggg cccggcctcc ggaggccggt
     5341 tggcgcggcg ccaggcggtg accgcgagca cggcacatgc gagcatcacc aggaacccga
     5401 cgacaccgag ccaggactgc tgcgcgacca tgccgcccat gagcagcccg atcccgcaca
     5461 ggaagccgag cacggccagg tagacccgac gacgggtgaa cgcgcgcact ccgtttccct
     5521 cgagcgccga cgcgaacttg ggatcttcgg cgtacagcgc tcgctccatt tgctcgagca
     5581 tgcgctgctc gtgctccgag agcggcacgg agacctccta ctcgtcggtc gcgcggggcc
     5641 gcgaccgggt ccgacccttt caggataggc gggaatccgg tccgtgaaac ccaccccact
     5701 gcgccaatcc gacggggcac ttcttccccg ccgagcgtca cgtcatgcca gcatacggtg
     5761 aggaatgacg ccgtgggcgg ggctgtgacg gactccgcga cagggccggc cgggctccgg
     5821 cgggccttcg cccgggggcg tccggccccg acgggtcagt cgcgctcggc gaggacgtgg
     5881 agctgggtgg cgacggagtg gaagcccggg tcctcggccg ccgccagctc cagccgcagc
     5941 agcgcctcgg cggcgccggg ctcggtgtcc accagcaccc cgggcaccag gtcggcgaag
     6001 acccgcaccc cgtgcacgga ggcggtgcgc agccccgcct ccgtgaccag gcgggtcagg
     6061 tcgtcggcgg tgaagcggcg gggcagggag tccgccgcgc cgtatcggcc gtccgggtcg
     6121 agcagcgcct gctgggcctc ggcgaagtgg ccggccagcg cgcgggccag caccgccccg
     6181 ccgcggccgg cggcgagcag gctgagcgag ccggccgggc gcagggcgtc caccacgttc
     6241 cgcacgccct cggcggggtc gtcgacgtac tccagcacgc cgtggcacag caccatgtcg
     6301 taccccccgg ggcggaccac accgagcagg ccgtgcacgt cgccctggac ggcggagacg
     6361 cggtcggtga cgccggcctc ggccgcccgg cgctccaggg cgaacagcgc gtccgggctg
     6421 gggtcgacga cggtcacgcg gtggccgagg cgggcgaccg gcaccgcgaa gttcccggtg
     6481 ccgccgccgg tgtcgaggac gtcgagcgca ggtcggtccg cggccttggc acgccgttcc
     6541 agggccccct ggaggacctc ccacaccacg gcggtacgaa ggctggcacg gggtcggatc
     6601 gggtccaccc ctcctggacg ggaccctgct cgggacatgg cgggcggctc tcctcgcgat
     6661 ggtgctggct gctgcggcgg acggcgtggg cgccgccccg tccccaactc taggccgtgt
     6721 ccggcgctcc ccgtcccggg tccggcgggc cgcggcgcta cgtgtccgac accgtcccgg
     6781 ccggggcggg ccggagcagc agcatgcgct ccaccaggcg caggaacatg ccggccgcgc
     6841 gcagcaggtc gtcggcgtcg cgcgggccgg cggccgcggg tatgccggcg tcggcgcgcg
     6901 ccctgcgctc ggcgccggcc gcgaacagcg cgctccactc gcccagttcg ggtgcgacct
     6961 cgggcagcac ctcccacgcg ctgcggatgc gggcgcgctt gcgggggctc tgctcgggcc
     7021 ggccgcggac ggcgagcacg gcggcggcgg tgcgcagggc ggccaggtgg gcggtggcgt
     7081 accgctcgtg cggggcgtcg aggtgggcgg cctcggcgag cccggcgcgg gcctgggcga
     7141 gcaggtcgag tgcggcgggc gccgcgccgg cgcggcgcag cacggggtgg atgtcggcgg
     7201 ggcttccgag gccggcgggg gcgccggagc tcccgggcgg cgggggcacg gacggtgtcg
     7261 gcggcatgga cggcatcgcg ggtagggcca tggcggcctc ctttctccgt tgcttcctca
     7321 tcggcttccc atcatcggtg ccaccactga caatcggctc tgacctgcgc ggattgcgga
     7381 cgctacgcgc gtatccgggt gcgcgcggcc gtgacgcggt ggaaacacgg gcgtcacggt
     7441 gcgggcagaa tcggggccat gacctccgca cgacgccggg cgacccggcg aaagctcttc
     7501 gaggccgccg tcaccctcat cgccgagcag ggcttctccg ccaccacggt cgacgagatc
     7561 gccgagcgcg ccggcgtcgc gaaggggacc gtctactaca acttcgccag caagaacgtg
     7621 ctgttcgagg agctgctgcg gcacggtgtc gggctgttga cggcgtcgct gcggcgggcc
     7681 gcggacgaga ccgcggcccg cggcgacagc cgggtcgacg cgctggacgc gatgatccgg
     7741 tccggcctgg cgttcatcgt gcgctacccg tccttcacgc agctttacgt ggcggagctg
     7801 tggcgtacca accgcacgtg gcaggacacg ctcatggcgg tccggcagga ggccgtcgcc
     7861 gtggtcgaga aggtgctcgg ggaggcggtg gagcgcggcg aggtgagcgg ggagatcgac
     7921 gtgccgctca ccgcgtccgc gctcttcggg atggtgctgg tcgccgcgct ggactggcag
     7981 gcgttccagc ccgagcggag tctcgacgac gtgcacgaga cgctgtcgcg gttgctccag
     8041 ggacgggtgg gcggctccgc ggcccaccga tgtgctcggt gatccgcggg ccaacccccg
     8101 ttgcggacgg tgcccgcacg cccggttccg ccgccccgtg ccggcgggtt cggggtgcgc
     8161 cccgtccgcg tgctccactc ttccggccgc gccgggcccc gccatccgta caggtactca
     8221 tccgcgcggc taggtatgcg ggcggggccg gggggacggc cgggcgcgcg gcgtggatac
     8281 gctcgcggga tgggacggat tgcggtggtg ggcgcgggga tggccgcgat ggcggtggcg
     8341 gcgcggctgg cgacgggcgg gcacgaggtc gtggtgcacg agcgtgcgga gacctacggc
     8401 ggggccgtgg ggcggtacac gcgggacggg ttcgccttcg acaccggccc gggcctgctg
     8461 gtgctgcccg cggtctaccg cgacctgttc gtgaagaccg gccgcgagcc cctggaggag
     8521 tgcgtcgggc tggcgcaggt ggaccccgcc ggccgccacc tgttcgccga cggcaccggc
     8581 gtgtcgctgc ccaacgcctc ccgctcgggg gtgatcgggg cgctggacgc ggcgttcggc
     8641 ccgggcggcg gcgagcgctg gagcgacgtg ctggtccggg cccgcgaggt ctgggagggg
     8701 gtgcgcaggc cgctgctgga ggagccggcc ggcgacccgg ggccgctcgc acgggacccg
     8761 tacccgggcc gccgcagggg cctgcggcgg cggccgccgt acctggcgga ggtggccgcc
     8821 gacgagctgg gcggcgaccc gcgggcggcc gcgctgctgg agtggtacgc cctggcgtac
     8881 gggctcgacc cgcggacggc gccggccgcg gcggcggtgc tgccgtacct ggagcagtcg
     8941 ttcggcctgt ggtacgtccg cggcgggatg cgggccctgg cggacgcgct gcacgcccgc
     9001 tgccgcgccc ggaaggtgga gttccgcttc ggctccgagg tggcgggcgt ggaggtgcgc
     9061 ggcggcgagg tgcaagggct gcggttcacc gacggctcga ccgccgccgc cgacgtggtg
     9121 gccgcctcgg taccgctgcc gtacctgccg caggagaccc tcccggcggc caccggcgac
     9181 ccgctgaccg gggcccggga cgagccgggg cgctgcaccg tgcacgtggc gctgcgcggc
     9241 tcccgcccgg ccggcacggc gcaccgtacg gtcgtgcacg ccgcggaccg cggggccgcg
     9301 ctggactggg tgttcgggcg cggccgggcg gaggtgcccg cggcggacgc gctgaccgtc
     9361 ggcgtgctgc ggcccgacga cccggcgggc cggccggacg acgggcacga ggcggtcacc
     9421 gtgacggcga cggtgccgcg gcacgccacc gcgggcgcgc gccacggcgc cggacgggac
     9481 tggtccgccg accgcttcgc ggacgccttc gccgagcgga tgctccaggt cgcggagcgg
     9541 gccgtgccgg gcctgcggga gcgggagttg tggcgcgagg tccgcacccc gctggacgtc
     9601 gagcgggaga cgggggcggc cggcggcagc gtgccggtcc cgtcgctgcc cggtgccggc
     9661 ggcgcccttc tgcgcccgcc caaccggacg gcgctcaagg gcctgtactt cctggggggt
     9721 tgggcccatc cgggcggcgg gctcccgcac gcggggatgt cggcggcgat cgtggccgac
     9781 ctggtcgccg gcggcccggg cggcagccgc tgacggctcc cggggccgcg ccgccggcgc
     9841 cgcgccgcac cgcggacccg ggaccaagat cgttaatcgt cgagcggcgg aattcaactc
     9901 atcgggcgga aaagggcgtt gccggcccac gacgccggcg ggcgccgacc tagcgtgagc
     9961 gctgtacagg tcatcggttg agcggaaggt cttaacggag atgccgcagc ccttcgaact
    10021 gcccgcgttc tacgtgccgt acccggcgcg gctgaacccc cacctcgaac gcgcccgcgg
    10081 gcactcgaag gactgggccc ggcagatggg gatgatcgag ggctccggca tctgggccga
    10141 gtcggacttc gactcgcacg actacgccct gctgtgcgcg tacacccacc cggacgcctc
    10201 ggggccggag ttggacctgg tcacggactg gtacgtgtgg gtgttcttct tcgacgacca
    10261 cttcctggac atcttcaagc gcaccccgga catggcgggc gcgaaggcgt acctggaccg
    10321 gctgccggcg ttcatgccgg tggacctcgc gcaggaggtc ccggagccgg cgaaccaggt
    10381 cgaggcgggg ctggccgacc tgtggcggcg gacggtgccg cggatgtcgc acggctaccg
    10441 gcggcggttc cacgagagca cccggcacct gctggaggag tcgctctggg agctgtccaa
    10501 catcagcacc gggcgggtgt cgaacccgat cgagtacatc gagatgcgcc gcaaggtggg
    10561 cggcgcgccg tggtcggcga acctgatcga gcacgcggcg ggcgccgagg tgcccgacgc
    10621 gatcgccgcg agccgtccga tgcgggtgct gcgcgactgc ttcgcggacg ccgtgcacct
    10681 gcgcaacgac ctgttctcct accagcgcga gatcgaggac gagggcgaac tgtccaacgc
    10741 cgtactggtg ctggaacgct tcctcgacct ggccccccag gaggccgcgg aggccgtgaa
    10801 cgacctgctg acctcgcgcc tccagcagtt cgagcacacg gcgttcaccg aggtggagcc
    10861 gctcttcgag gagttcgggc tcgacccggc gcagcggctg gccgtgttcg gctacgtcaa
    10921 ggggctccag gactggcagt ccggcggcca cgagtggcac ctgcgctcca gccgctacat
    10981 gaacggcgcg gacgaccgcg cgcgggcggt gggcgtgctc gccgggccga acggcatcgg
    11041 cacctcggcc gcgcagatcg ccggctcgct cgccgcgacg ctgccgcagc gcgcccgcgc
    11101 ctacggccac gcgccgttcc agcgggtcgg ctgggtgcgg cgggcgccgg tgcccatgcc
    11161 gttccccacg acgctcagcc cgcacctgga cgcctcccgc gcgcacaacg cggactggag
    11221 cggacggatg ggcctgctgg acgccgagcc gggcttcccg gtgccgggcg gcctgtggaa
    11281 cgggaggaag ctcgccgcct acgacttcgc gctgtgcgcg gcgggcatcc acccggccgc
    11341 gtcgagggag gagttggacc tcacgaccga ctggctgacc tggggcacct acggcgacga
    11401 ctactacccg ctcgtcttcg gccgggccgg cgacatggcg gcggcccgga tcaccaccga
    11461 gcgcttcaag ctgttcatgc cgctggacgc gggcgcggtg ccgccgccac tgacggcgct
    11521 ggagcgctcg ctcgccgacc tgtggcggcg caccgcgggt ccgatgacgc cggccgagcg
    11581 gcggcggttc cgcacctcga tcgaggagat gtgcgagagc tggctgtggg agctggccaa
    11641 ccagaagctc aaccgggtgc cggacccggt ggactacatc gagatgcgcc gcaggacctt
    11701 cggctcggac ctgacgatga gcctgtcccg gatcggccac ggcgacgcgc tgccggacga
    11761 ggtctaccgc tcccggccgg tgcgcggcat ggaggtggcc gcccaggact tcgcctgcct
    11821 gctcaacgac gtgttctcct accgcaagga gatcgagttc gagggcgaga tccacaacgc
    11881 ggtgctggtg gtgcagaact tcctggactg cgggccgcag caggcgatgg acgtcgtcgg
    11941 ggacctgatg gccgcccgga tggcggagtt ccagcacatc accgagaccc aactgcccac
    12001 gctgctgacg gagttcgacc tcgacgagaa ggccggcgag gtcctgctcg gctacgtcca
    12061 ggagttgcgg gactggatgg ccggcatcct cacctggcac gagggctgcg cgcgctacac
    12121 ggaggagaca ctgctggagc actaccctca cgtggcggcc gcgccggcgt cgcggcaccc
    12181 gtgggccacc ccgtcgggcc tgggcctgtc cgcggcgcgg ctgcccgccc tgctgggcga
    12241 ccgccggggc cgtccggcgg cggacgccgg tcagtagcgg tacgggtcgt acgggtcggc
    12301 gtactcctcc tgctgctgcg gctgttggcc gtgctgctgc tcgtacggcg gctggtgcgg
    12361 ctgctgcggg atgtacgcct gctgctggtc gtacacctgc tggtcgtagc cgtagccgcc
    12421 gtacggctcg gccgcgggct gctgcgggta gggctgcggg aaccgccagt ccccgccggc
    12481 gtcctggccg ccgtacccgc cgccggtgtc ctggccaccg aacccgcccc cggtgtcctg
    12541 gccaccgaac ccgcccccgg tgtcctggcc gccgaacgcg ctgccctccg tgccgcggga
    12601 gttgccgaac acgtcgtact cgtccgggtc gtagccgtag gacgcggcgg ccgcggcggc
    12661 cgccgcgggc tgctcctggt agccgccgcc ctggccgccc tggtgctggc cctgctccca
    12721 ggacggctgc tgctcgtacc cggtccagct ctggtagccc tgcgcgccgt acccctcgta
    12781 gccgccgctg gtgtacgggt cgggggtgta cgtcgactgg ccgtcgtaga gcgggtactc
    12841 gccgctgtcg tcgagcatgg gcatcggctg gtacaccgcc tgctcggcgc cgtacccgtc
    12901 ctggccgtca ccgggcaggg cggagaagtc gtgcaccgcg gtggcgccga cgcccgccaa
    12961 ctcctcggcg gactgctgcg gcccggccgg gtcgtcggcg tccggctcga tcgggccgac
    13021 ctccagcacc ggttcggccg ggcgcgtgcc cgccgccctg cggcggcggc tggagccggg
    13081 gcggccgcct atcgaccacc ccgtggagaa cccgcgcttg taggagagcg tgaccatgct
    13141 ctgcccggtg ccgaaggcca ccgcgcccag caggatgagc acgacgctgc gctcggcgac
    13201 cccgaccacc aggccgagga acccggcgaa ggcgagcacc cgccagcgca gccgggcctt
    13261 gtactgcaac agcacctcgc ccagcagcca cagcgcgacg atgccgaacg cgatgtagag
    13321 caccgagtaa cccatgtgcc cacttcctca cctaggggtc acgccgcctg ctggtgcagc
    13381 ccgaggttct cgtagatctc cagcgatgcg gtggagtggt taagggtaat gaagtggagc
    13441 cccggaatgt cctcggccag cagccgccgg cacatctcgg tggtgaactc gatgccgatc
    13501 gcccgcaccg ccgccgggtc gtcctgcacc gcgaggaggc gttcggccag gtcgggcggg
    13561 aacggggcgt tgccgagctg cgagaaccgc tcgatctgcc ggacgttggt gaccggcatc
    13621 acctcgggga tgatcggcac ggtgcagccc gcccggtcca cccggtcccg cagccgcagg
    13681 tacgcgtccg ggtcgaagaa catctgggtg atcgcgaagt cggcgccggc ccggcacttg
    13741 tcgaggaagt ggcgggtgtc ctcggccggg tcggtggagc gcgggtgcat ctcggtgaac
    13801 gccgcgacgc ccacgcagaa gtcgcccgac tccttgacca gtcgcaccag ctcggccgcg
    13861 taggtcagcc cctgcgggtg ggccacccac tcgcccatcg ggtcgccggg cgggtcgccg
    13921 cgcaccgcga ggatgttgcg gatgccggcg tcggcgtact ggccgatgat gttgcgcagc
    13981 tcggcgaccg agtggttcac cgcggtcagg tgggcgcacg gggtgagggt ggtgtccgac
    14041 acgatgcggt cggtggcgcg cacggtgccc tcccgggagg agccgcccgc gccgtaggtg
    14101 accgacacga aggtcgggcg taccgcttcg atccgccgga tcgcgttcca cagcgtgcgc
    14161 tcgcccttct ccgtccgcgg cgcggcgaac tcgaaggagt aggagcggtg gccggacgcg
    14221 agcagctcac ggatcgtggt cgcgcggtcc gtacgtgtgg atgaagtccc cagggccatg
    14281 caagcaggct aacgtgtggc ggccaccaca cgttagcgcg tcccgccgtc cccgggggtg
    14341 ccccgcgccc ctttcccgag gtgccccgcc cccgccccgg ggtgcccgct gccgcggagg
    14401 tccggccggc ggcccgggtg cgccggcgac agcccctcgg ggccggtggg acccgccccg
    14461 gcgtggcggg ctggtcgcgc cgttcccccg cgcccctcgg gggcaccgcc ttccgtggga
    14521 gcgggagggg cgccgtcagg ccggcgaggg ctccgcgcgg cggatcgtac gggccagtgc
    14581 ggcagcggct tcgtaggggt cgggggcctc cgtgatcgcg cggacgacga cgatgcggcg
    14641 ggcgccggcg gcgaggacct cgggaaggtt gccgaggtcg atcccgccga tcgcgaacca
    14701 gggccgcggg gtgccgagcg cggcggcgtg gcgcaccagg tccagcccgg gcgcgggccg
    14761 ccccggcttc gtcggggtcg gccacaccgg accggtgcag aagtagtccg ccccgggctc
    14821 gaccgccgcc gcgtccacct ccgcctcggc gtggcaggag cgtccgatca gcacatcggg
    14881 cccgagcagg gcgcgggccg cgggcaccgg caggtcgtcc tggcccaggt ggagcacgtc
    14941 cgcgccggcc gcgtgcgcga cgtcggcgcg gtcgttgacc gcgagcagcc tgccatggcg
    15001 ttcgcacgcc tcggcgagca cgtcgagcgc ggccagctcc tggcgggcct cgatcccctt
    15061 gtcccggagc tggatgacgt ccacgccgcc gctcagcgcc gcgtccgcga acgcggcgag
    15121 gtcgccgcgg gtggtgcgcg cgtccgtgca gaggtacagc cgcgcgtcgg cgaggcgggc
    15181 ggacgcagtc ggggtgggca tcacgggctc ccggggtcgg tgcgccccgg ggcgggccgc
    15241 cgccgcgcgc ggacccggac ggggtacggg cgcggcgggc ggcccgcggc gggcgcgggc
    15301 tacacggcga gcgcctgcgc gcggcgcttc acctcggtcc cgcgattctc gcgcagcgcg
    15361 ttcgccgggg tgccgggcag ggtcgggtcg ggcgtgaaga gccactccag ggcctcgtcg
    15421 tccgtgaacc cgtcgtcctt caggagcgtc agcgtgcccg gcagcccctt gacgatcttc
    15481 ccgtccccga tgaagtcgcc cggcaccatc aggaccttgt tctccccgcg ccggaccgcg
    15541 atgagctgcc cttccttgat cagcggccgg atccgggtca cttccagacc gagacgctcg
    15601 gcgacctcgg gcagggtgag ccaggagggg acgagagcgt caatgcgtgc gtcaaccgac
    15661 gagtaaacag tcacgggaca agcgtgccac ctacggccga caaccgctcc cagcgctgag
    15721 ccgtcacggt gccgtgtacc gccggccgct ccggacgggc gggaccaccg gcggggccgg
    15781 cggccgtcag cgcggcacgg cggacttcag cggcaccgcc gggtccgcgg cgagcaccgg
    15841 gtccggcgcg gagcccgcgg cgatcagctt ccgggcctgc gccatgtccc gcggccggcc
    15901 caccgccagc accgccacca gcacgccgcg gcgcagccag agcactgacc aggagccgtc
    15961 ggaggggtcc ccccgggaga tcagcgtgtc ctcctcccgg tggaacccgg cgtactgcac
    16021 gaaccgcccg aactgctcgg accagaagta cggcaccggg tcgtacgcct cctcgccgcc
    16081 gagcaggttc gcggcggcgg tgcgcgggcc ctggaccgcg ttgtcccagt ggtggacgag
    16141 cagccgccgg ttgtagcggg ccgaggggaa ggacgcgcag tcgccgaccg cgaacacgtc
    16201 gggcgcggtg gtccgcagcc gctcgtccgc gcgcacggcg ccctgggggt ccagggtcac
    16261 cccggagccg gccagccagc cggtggcggg gcgggcgccg atcccgacca ccacggcgcc
    16321 ggccgccagc cggctgccgt cggcgagcac caccccgccg gcctcgaccc cggccacggt
    16381 ggtgccggtc cgcagggtca cccccgcctc gccgtaccag ccggtcatgt gcgcggtgac
    16441 ggacgcgggc agcacaccgg ccagcgggcg gtcggcggcc tccaccaccg tcacctcgca
    16501 gccggcctgc cgggccgccg tcgcgaactc cgcgccgatc cagccggcgc cgaccaccac
    16561 gacgtgctcg cgccgttcga gcacggggcg cagcgcggcg gcgtcgtcca gggtgcgcag
    16621 cgggtgcacg ccggccaggc cggcggtgcc gggcagcacc accgggtagg cgccggtggc
    16681 caggacgagc gcgtcgtagg ccaccaggcc ggcgtcggtg accaggtggt gctgttcggc
    16741 gcgcagcgcc tgcgcgtgca ccccgagccg caactccacg ccgagcgcac ggaagtcgac
    16801 gtcgaagcgc acgtcggcca gggcgccgcc ctccgcgccg aggagcaccg ccttcgacaa
    16861 cggcgggcgg tcgtacggcg ggtgcggctc gtccccgagc agggtgacgg ggccgcgcca
    16921 gccctgctgg cgcagttcca cggccgtctg cacgccggcc atgccggccc ccacgatcac
    16981 tgcgcgacgc tcgtccaccg ggacacgtta gcgcgttggc gccgcgccgg ggcggggtcc
    17041 gcacggcagc cgaaggcggc ggccgccggg aaggggccct cggctaagct ggcggcaagc
    17101 gaattcgcgg gagcccgggc gcaccgggct gagagggcgg ctggccggcc gccgaccgta
    17161 cgaacctgat ccgggtcatg ccggcgaagg gagcagcgaa gactcatgcg tacccgaaca
    17221 gcggacgtcc tcgtcgtggg gggcggcatc atcggcctgg tgacggcgtg gcgcgccgcc
    17281 cagcgcgggc tgtccacggt ggtggccgac ccctcgccgg gcggcggcgc cgcccacgtc
    17341 gcggcgggga tgctcgccgc ggtcaccgag ttgcagtacg gcgagcagac actgctcgac
    17401 ctcaacctgg cgtcggcggc gcggtatccg gacctcgtcg cggaactggc ctcggacacc
    17461 ggcatggacg ccgggtaccg gccgtgcggc accctcgcgg tggcgctgga cgcggacgac
    17521 cgggcggacc tgcgcgacct gcacgccttc cagacctcgc tgggcctggc cgcgcagtgg
    17581 ctgagcgggc gggagtgccg ccggctggag ccgctgctcg cccccggggt gcgcggcggg
    17641 ctgcgggtgg acggcgacca ccaggtcgac ccgcgccggc tggccgcggc actgctgcgg
    17701 gccgcggacg cggcgggcgc ggagttcgtc cgggcgaagg cggcccggct ccgatgcgcc
    17761 ggcgaccggg tcacgggtgc cgaactcgcg gacggcaccc gggtgtcggc gggccgcacc
    17821 gtgctggccg cgggctgcga gagcggccgg atgccggggc tgccgcagga cgcgctgccg
    17881 ccggtgcggc cggtgaaggg gcagatcctg cggttgcgga tgccggcggg gcaggcgccc
    17941 ttcctgtccc ggacggtgcg cgcggtggtc cgcggcagcc atgtctacct ggtgccgcgg
    18001 gagaacggcg aactggtcct gggcgcgacc agcgaggagt tcggctggga cacggcggtg
    18061 accgcgggcg gggtctacca gttgctgcgc gacgcgcacg acctggtgcc gggcatcacc
    18121 gaactcccgc tcaccgagac gctcgcgggg ctgcggccgg gctcccccga caacgcgccg
    18181 ctgctgggcc cctcgcccct ggacggcctg ctgctggcca ccgggcacca ccgcaacggc
    18241 gtgctgctca ccccgatcac cggggacgtg ctcggccatg tcctggacac cggtggactc
    18301 cccgactacg ccgccccgtt cgcggtcgga cggttcgccg ccggagcggc gggaaccggg
    18361 acggcggcgc ccggcgcggc gggaagcgga cggcccggaa cgccgccggg cgggacaccg
    18421 ccgggcgcga cgcccccgct cggcgccgga cacgtcgggg cgtcggcccg tgaggagcag
    18481 tcggtatgac gatcaccgtg ctcgtcaacg gggagcggcg cgccctggag gacccggtcg
    18541 aactcggcgc tctcgtcgcc cggttcacct cggcgccctc cggggtggcc gccgcgctca
    18601 acgagaccgt cgtgccgcgc tcgcgctggg cggcgacccg gctggccgag ggcgaccggg
    18661 tggagatcct caccgcggtc cagggaggct gagcgtggac accacacgaa ccgcgccctc
    18721 cgaggcgccc gcgggcgccg gcgatccgct gcgcatcggc ggcgtagtct tcgggtcccg
    18781 cctgatcatg ggcaccggag gggcgccgag cctcgacgtg ctggagcacg cgctgcgcgc
    18841 gtccggcacg gagctgacga cggtcgcgat gcggcggatg gacccgaccg ccaagggctc
    18901 ggtgctctcc gtgctggacc ggctgggcat ccgggtgctg ccgaacacgg ccgggtgctt
    18961 caccgcgggc gaggcggtgc tcaccgcccg gctcgcccgg gaggcgctgg gcaccgactg
    19021 ggtcaagctc gaagtgatcg ccgacgagcg gacgttgctg ccggacccgg tcgaactcct
    19081 cgacgcggcc gagacgctgg tggacgacgg gttcacggtc ctcccgtaca ccagtgacga
    19141 cccggtgctc gcccgcaagt tggaggacgt cgggtgcgcc gcggtcatgc cgctcggctc
    19201 gccgatcggg tcggggctcg gcatccgcaa cccgcacaac ttccagctca tcgtggagca
    19261 ggcgtccgtg ccggtcgtcc tcgacgccgg cgccggcacc gcgtccgacg ccgcgctcgc
    19321 gatggagctc gggtgcgacg cggtcatgct cgcgtccgcg gtgacccggg cgcagcggcc
    19381 cgacctgatg gccgcggcca tgcgggacgc cgtcaacgcc ggccgcctcg cccaccgggc
    19441 cggccgcatc ccccgcaggt acggtgccct cgcctcgtcc ccggtcgacg gtgcggcttc
    19501 cctgggggcg cccccagtcc cccgcgctta gggcgccgcg ctcccccgcg ccccggcggc
    19561 ctgctgagcg cgcggttccc cgcgcccctg gtcaggagcg cggcggggat acctccccgg
    19621 cgaagctctg gggggaggaa ccgcgcgcgc aaccggccgt ccgggcgcgg gccggggacg
    19681 agagggcaac ccccgcggcg gggagccgca ccccacgggc acgagagagc aaccgtcgca
    19741 gcggggagcc gtgggcccgc gccggcgggg gcccaccccg gaaggagggc gcccccggac
    19801 ggtcacaacc gcgtagcgaa tccgcacggg tgggacacat tgcgatccac ccgcgccgaa
    19861 ccgcacgaag tgcctcgtag aatcggtggc cgtggacacc agcgtgcagg acccgcttgt
    19921 cgggcaggtg ctcgacgggc gctacctggt cgaggggcgt atcgccgtcg gggggatggc
    19981 gacggtctac cgcgccacgg acacccgtct ggaccgggaa ctcgcgctga aggtgatgca
    20041 ccccagcctc gccgacgacg ccgtgttcgt ggagcgcttc atccgcgagg cgaaggcggt
    20101 cgcgaagctg gcgcacccga acgtggtggg cgtcttcgac cagggcaccg acggcacgta
    20161 cgtgtacctc gcgatggagt acgtggccgg ctgcacgctc cgcgacgtcc tgcgcgagcg
    20221 cggcgcactc caggtgcacg ccgccctgga catcctggaa ccggtgctcg cggcgctcgg
    20281 cgcggcccac cgcgcgggcc tggtgcaccg cgacatgaaa cccgagaacg tgctgatcgg
    20341 cgacgacggc cgggtgaagg tcgccgactt cggcctggtc cgggtgatcg acacgaagac
    20401 gagcgcgtcg accggcgcgg tgctcggcac cgtgtcgtac ctggcaccgg agcagatcgg
    20461 ccacggcacc gtggaccagc gcgccgacgt gtacgcctgc ggcgtggtgt tgtacgagat
    20521 gctggccggc cgcaagccgt acgacggcga caccccggtg aaggtgatgt accagcacgt
    20581 caacgaggac gtgccggccc cctccgctgc cgtgccgacc gtgccgccgc tgctggacgc
    20641 cctggtggcg cgggcctgcg cccgcccgca gcaggagcgc ccggcggacg cggtggaact
    20701 gctcgcggag gtccgcacgg cacgggccgc gctgtccgcg gaggaactgg acgcgctgcc
    20761 gggcggcccg gcggcccggc cgtccgggcc cgtggcggtg ccgggggccg agccgtcgga
    20821 cacggtgccc gcggccggga ccaccgggac tgccgggacc gccgggacgc cgccgcccgg
    20881 ctccgaggag cccaccagcg tcgtggcgct ccccgaggac gccctcaccg accgcaccgc
    20941 ccgcctgatg ccgcccgccc cggcgcccga cgaccctccc gccgccccgg cggccgggtg
    21001 gttccgctcg cgccgcggcc cgctcgccgt gctcgtcgcc ctcctggtcg tgctcggcgt
    21061 cggcgccggc gtctggtaca tcaacgacgg ccagttcacg accgtccccg gtgtgctgtc
    21121 gctgccgcag gcgaaggcgg agcagaagct ggaccgggcc ggcctggaca gcaaggtgaa
    21181 gcagggcttc tcgctgacgg tgccgcgcgg cagcgtgatc gccaccgacc cctcccccgg
    21241 ccggcgcatc cgcggcaacg gcacggtgac gctgacggtc tccaagggcc cccagcacgt
    21301 ccgggtgccc gacgtcgccg ggcgcgacct ggccaccgcc cgcaaggaga tcaaggaagc
    21361 gagcctggtg ccgagcacgg tcaccgagtc gttcagcgac gacgtgccgc gcggcagggt
    21421 ggtcgccacc gatccggcgg gcaccaccca gctcgacccg ggcacccgcg tcgcgatcac
    21481 cgtctcgcgc ggcaggccgg tcgacgtccc ggacgtggtc ggcgagtcgg tcaccgacgc
    21541 gcagcaggac ctggaggcgg ccgggctgaa ggtggtgctc gcgccgggca aggtcttctc
    21601 cgacgtggcc gacaaggaca aggtcgcgct ggtgtccccg ggcaagggca gccaggtcgc
    21661 ccggggcgac tcggtgacga tcaccgtctc caagggccag cagcagttcc cggtgccgga
    21721 cgtgaccggg aagagctcgg gcgacgcgaa gaagatcctc caggccgcgg gcttcgacgt
    21781 ccgcgtgatc aacgtcttct tcggcagcac cgtcttcagc cagtcgcccg acggcggcag
    21841 ccaggcgccg aagggcgcca cgatcaccct ctgggtgcgc tgagaccggt ggcggacccg
    21901 cacggacacg agcacggacg agtgacgcac cagtgaacga ccagacgacg gctcccggcc
    21961 gcctgcgcaa cccggtcggc gcccacgtgc cggtggcggg cggcctggcc gccaagggcc
    22021 tggcctacgc cgagcagctc ggcgcggagg cggtgcaggt cttcgtggcg aacccgcggg
    22081 gctgggcgac cggcccgggc gaaccggcgc aggacgagga gttccgcgcc cgctgcgccg
    22141 aggcggggct gcccgcgtac gtccacgcgc cctacctgat caacttcggc tcgcacaccc
    22201 cggagaccgt cgaccgctcg gtggcgtcgc tgcggcactc gctgcgccgc gggcggcgga
    22261 tcggcgcgct cggggtc
//
