LOCUS       NZ_AP018365            21029 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  Streptomyces sp. SN-593 chromosome.
ACCESSION   NZ_AP018365
VERSION     NZ_AP018365.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. SN-593
  ORGANISM  Streptomyces sp. SN-593
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Panthee,S., Kito,N., Hayashi,T., Shimizu,T., Ishikawa,J.,
            Hamamoto,H., Osada,H. and Takahashi,S.
  TITLE     beta-carboline chemical signals induce reveromycin production
            through a LuxR family regulator in Streptomyces sp. SN-593
  JOURNAL   Sci Rep 10 (1), 10230 (2020)
   PUBMED   32576869
  REMARK    DOI:10.1038/s41598-020-66974-y Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Takahashi,S., Toyoda,A., Sekiyama,Y., Takagi,H., Nogawa,T.,
            Uramoto,M., Suzuki,R., Koshino,H., Kumano,T., Panthee,S., Dairi,T.,
            Ishikawa,J., Ikeda,H., Sakaki,Y. and Osada,H.
  TITLE     Reveromycin A biosynthesis uses RevG and RevJ for stereospecific
            spiroacetal formation
  JOURNAL   Nat Chem Biol 7 (7), 461-468 (2011)
   PUBMED   21642985
  REMARK    Publication Status: Online-Only
REFERENCE   3
  AUTHORS   Panthee,S., Takahashi,S., Takagi,H., Nogawa,T., Oowada,E.,
            Uramoto,M. and Osada,H.
  TITLE     Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds
            from Streptomyces reveromyceticus SN-593
  JOURNAL   J. Antibiot. 64, 509-513 (2011)
REFERENCE   4
  AUTHORS   Takahashi,S., Takagi,H., Toyoda,A., Uramoto,M., Nogawa,T., Ueki,M.,
            Sakaki,Y. and Osada,H.
  TITLE     Biochemical characterization of a novel indole prenyltransferase
            from Streptomyces sp. SN-593
  JOURNAL   J Bacteriol 192 (11), 2839-2851 (2010)
   PUBMED   20348259
REFERENCE   5  (bases 1 to 8833490)
  AUTHORS   Takahashi,S., Ueki,M., Toyoda,A., Ishikawa,J., Sakaki,Y. and
            Osada,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2017) Contact:Shunji Takahashi Chemical Biology
            Research Group, RIKEN Center for Sustainable Resource Science
            (CSRS); Hirosawa 2-1, Wako, Saitama 351-0198, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Phrap v. 0.990329
            Genome Coverage                   :: 16x
            Sequencing Technology             :: ABI 3730
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016756395.1-RS_2024_05_21
            Annotation Date                   :: 05/21/2024 03:58:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,420
            CDSs (total)                      :: 7,334
            Genes (coding)                    :: 7,181
            CDSs (with protein)               :: 7,181
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 153
            CDSs (without protein)            :: 153
            Pseudo Genes (ambiguous residues) :: 0 of 153
            Pseudo Genes (frameshifted)       :: 35 of 153
            Pseudo Genes (incomplete)         :: 136 of 153
            Pseudo Genes (internal stop)      :: 8 of 153
            Pseudo Genes (multiple problems)  :: 25 of 153
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:29:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1482776
            Orig. end                         :: 1503805
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP018365.1.
            This work was done in collaboration with Shunji Takahashi, Masashi
            Ueki, Atsushi Toyoda, Yoshiyuki Sakaki and Hiroyuki Osada (RIKEN)
            and Jun Ishikawa (National Institute of Infectious Diseases).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21029
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="11"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21029
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21029
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11029](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11029)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    721..735
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     misc_feature    1046..1061
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.19"
                     /tool="antismash"
     misc_feature    1058..1074
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.95"
                     /tool="antismash"
     gene            complement(1061..1693)
                     /locus_tag="RVR_RS06285"
                     /old_locus_tag="RVR_1778"
     CDS             complement(1061..1693)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087869.1"
                     /locus_tag="RVR_RS06285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1778"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_202232897.1"
                     /transl_table=11
                     /translation="MPRPGTGPAAPGPESARGALRRVPVQRRSAERLSRILDACARELD
                     EVGYERLSTRAVAARAGVPIGSVYRFFSDKRAMADALGRRNLDEFLDRTAARLAGPGTG
                     ADWRAAVDVLVDEYTAMKRTAPGFALVEFSAPGETNQDLADRLPELLGDRLTADPADPR
                     LRLALTVAVEAADAALQLAFRTGQMGDSRVIAEVKVLVRAYLGTVLE"
     gene            1977..3299
                     /gene="hmgA"
                     /locus_tag="RVR_RS06290"
                     /old_locus_tag="RVR_1779"
     CDS             1977..3299
                     /EC_number="1.13.11.5"
                     /GO_function="GO:0004411 - homogentisate 1,2-dioxygenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006559 - L-phenylalanine catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006572 - tyrosine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hmgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558972.1"
                     /locus_tag="RVR_RS06290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1779"
                     /product="homogentisate 1,2-dioxygenase"
                     /protein_id="WP_202238426.1"
                     /transl_table=11
                     /translation="MELRDAGHGDEGRDLGYQPGFGNEHSTEAVPGALPVGRNAPQRAP
                     LGLYAEQLSGTAFTEPRAHNHRSWLYRIRPSAAHPPFHRVPNGALRSAPFHDVEPDPNR
                     LRWGPLPLPDEPTDFVQGLVTVGGNGDVLRREGIGIHWYAANASMDRRVFSSADGEFLI
                     VPQEGALLLRTELGVLRADPGHVALVPRGVRFRVELLGPTARGYVCENYGRPFQLPDLG
                     PIGANGLANARDFLAPVAAYEDREEDTEVVNKFGGNLWAAVYDHSPLDVVAWHGNHVPY
                     LYDLHRFNVLGSISYDHPDPSIFTVLTSPSDTPGLAGADFVVFAPRWLVGEDTFRPPYF
                     HRNVMSEFMGLVEGAYDAKAEGFVPGGASLHNMMSAHGPDHTTFDRASTAELRPQKVDD
                     GLAFMFETRWPVVPTGFALGAGHRQEGYDAVWEGLRRNFRP"
     gene            3305..4051
                     /locus_tag="RVR_RS06295"
                     /old_locus_tag="RVR_1780"
     CDS             3305..4051
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007263247.1"
                     /locus_tag="RVR_RS06295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1780"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_202238427.1"
                     /transl_table=11
                     /translation="MNAFAPDSLVLNRRLPLWYQVSQSLRASILGRRPDAPLRLPTEED
                     LAAHYGVSVLTMRQALKELEAEGLISRHRRRGTFIEPTALRGAPVRLLGSVDAVVAQQS
                     GGRTTVLAHGPAPLPPEAAEHFPDLTEAVRFRRLRHDESGEPSNWAENHVRPELAARID
                     PADLERWPMTKILRDVLGVRISRITDTLEAGLADPGTARLLRVPLLSPILHCTGVTYDE
                     TGRAVDVVRIHYRGDRFSFTVTMEAP"
     gene            4066..5322
                     /locus_tag="RVR_RS06300"
                     /old_locus_tag="RVR_1781"
     CDS             4066..5322
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059609.1"
                     /locus_tag="RVR_RS06300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1781"
                     /product="type ISP restriction/modification enzyme"
                     /protein_id="WP_202232898.1"
                     /transl_table=11
                     /translation="MRVVSDDAPLLHDLMPWSVRPLRIGRGWPMASEPACLRARWTLLT
                     TAPDEATRNALLRPTRARGPHTPVGQLPGHPTPTTAIAREAGRCPEPVRVQHGPFDQQW
                     LIPDHRLIDVARPELWRIADDRQLFAVEHSPLPDTAEAVVTFSALLPDGRSPAGRPALI
                     RPLYRRPGGRDPNLAPGLTGWLASRLDTGVTAEDTLAWIAAAARPGHRGCEVPLPRDLD
                     QWQEGTALGRRSLWLHTRGARCADPGQGRDASRLRPPGGSRPYVRAALPERPRPDDLRY
                     DPQERALWVGTGQVAPVAPEAWEATAGGVRVLEAWYGRRTAPGEPGSLEALRPAAWTRA
                     TTSELLELIGVLTLLAGLREEVADFTARSAAEGVDRAGAAGAAALRAAGVLPVPAARRR
                     PASVLEHHEEGPDGQFALL"
     gene            complement(5433..5696)
                     /locus_tag="RVR_RS06305"
                     /old_locus_tag="RVR_1783"
     CDS             complement(5433..5696)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123458.1"
                     /locus_tag="RVR_RS06305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1783"
                     /product="hypothetical protein"
                     /protein_id="WP_202232899.1"
                     /transl_table=11
                     /translation="MEQIAMHSRPRVPAINCGTTASSARLDRHLSILAGPAVPQREAEE
                     ATVLLRELTSRDATRVRTDKGARVSLFAPLRRLRRSLFGNHR"
     misc_feature    5758..5773
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     misc_feature    5902..5916
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.36"
                     /tool="antismash"
     misc_feature    complement(5910..5926)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     misc_feature    5921..5937
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.54"
                     /tool="antismash"
     gene            6031..7155
                     /locus_tag="RVR_RS06310"
                     /old_locus_tag="RVR_1784"
     CDS             6031..7155
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020665549.1"
                     /locus_tag="RVR_RS06310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1784"
                     /product="DUF5925 domain-containing protein"
                     /protein_id="WP_272933059.1"
                     /transl_table=11
                     /translation="MPPTSPAADATDAAAADPFRTLPVHLRLDDSDSPSDVVDALFLGR
                     FTSGRQPFARSSSLENVKPGLTLLPPDATVLRQARDKDRSALLAEGEDWTILVSRWSRG
                     ADVTVTATSDELAERVLKSAVEDAEDEPEPQPENVTMGFWYVSPRRGPHRTTRKISAGT
                     WDELRGNYSAPVADAMDGLMKMTADDITGRLLLLHGPPGTGKTSALRTLARSWRDWCQV
                     DCVLDPERLFNDVGYLMDIAIGEDESEGGRWRLLLLEDCDELIRGQAKHETGQALSRLL
                     NLTDGLLGQGRNVLVGITTNEALERLHPAVVRPGRCLARIEVGPLNREEAVRWLGTGEG
                     VGREGASLAELYALRRGTSPTLAVPPQADGGLYL"
     misc_feature    6075..6089
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 17.99"
                     /tool="antismash"
     gene            complement(7208..7579)
                     /locus_tag="RVR_RS06315"
                     /old_locus_tag="RVR_1786"
     CDS             complement(7208..7579)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575414.1"
                     /locus_tag="RVR_RS06315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1786"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_202232901.1"
                     /transl_table=11
                     /translation="MSLKITIDPDATAAPYEQVRGQIAEKARSGELPVHHKLPTVRGLA
                     EQLGLAANTVAKAYRALEADGVIETRGRHGTYVAAGDAMAREVADAAAGYARRVHRLGL
                     DRDAARAAVEEALRAEYGG"
     gene            complement(7576..8739)
                     /locus_tag="RVR_RS06320"
                     /old_locus_tag="RVR_1787"
     CDS             complement(7576..8739)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (58-153). E-value: 3.8e-09. Score:
                     27.0. Matches aSDomain: nrpspksdomains_RVR_RS06320_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572137.1"
                     /locus_tag="RVR_RS06320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1787"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_202232902.1"
                     /transl_table=11
                     /translation="MSTDATSTESGPDPDARQYWDAAADHFDDEPDHGLRDPGVRSAWE
                     ARLRSWLPAGPSDVLDLGCGTGSLALLAAADGHRVTAVDRSERMVALARAKLSGTRARV
                     LVGDAARPPVAAGGFDVVLVRHVLWALPDPEEVLRRWADLLRPGGRLVLVEGRWGTPPA
                     GIAADTLVRLAAPLGGSVQVEQLGHDTPLWGRAVRDERYVAVVRPAHRAARRHTEIVDV
                     HLLLLRGREVLLSRRDGTGYADGLLHAPSGHLEDGEDVRSGMLREAREEIGLDLAPGDL
                     EAAMVMQHRAPDGRARIGWFFVAHHAAGSPEPVNREPDKCSELGWYPLDALPDDMVAYC
                     RAAVDGFLAGHRFLLHLHESGDSIAHAPDGPARAVPLAAAAVPVSGV"
     aSDomain        complement(8281..8565)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RVR_RS06320_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="3.80E-09"
                     /label="RVR_RS06320_oMT.1"
                     /locus_tag="RVR_RS06320"
                     /protein_end="153"
                     /protein_start="58"
                     /score="27.0"
                     /tool="antismash"
                     /translation="VLDLGCGTGSLALLAAADGHRVTAVDRSERMVALARAKLSGTRAR
                     VLVGDAARPPVAAGGFDVVLVRHVLWALPDPEEVLRRWADLLRPGGRLVL"
     gene            complement(8914..9789)
                     /locus_tag="RVR_RS06325"
                     /old_locus_tag="RVR_1788"
     CDS             complement(8914..9789)
                     /NRPS_PKS="Domain: Abhydrolase_1 (56-207). E-value:
                     1.7e-14. Score: 45.9. Matches aSDomain:
                     nrpspksdomains_RVR_RS06325_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671793.1"
                     /locus_tag="RVR_RS06325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1788"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_202232903.1"
                     /sec_met_domain="PF00561 (E-value: 4.7e-11, bitscore: 41.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.5e-09, bitscore:
                     36.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLSWRRLLAVFALTTAMAVAPTAVASASTGSASAGSAPTSGWNN
                     YSCRPSAQHPRPVVLVHGTFANGTDNWLAFAPYLVARGYCVFSLDYGMLPGENLIGGLG
                     PIADSAQQLSDFTDRVLAATHASKVDIVGHSQGGMMPRYYLQFLGGASKVNALVALAPD
                     NHGTTLDGLTALLPYFPGASDFLQDDLPGLADQVAGSDFQRELNAGGDTVPGVQYTVIS
                     TIYDEVVTPYTTQALSGPNVHNVVLQDLCPLDVSEHVAIGLTDRIAFHEAANALDPAHA
                     TRTTCLSAAS"
     aSDomain        complement(9169..9621)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RVR_RS06325_Abhydrolase_1.1"
                     /evalue="1.70E-14"
                     /label="RVR_RS06325_Abhydrolase_1.1"
                     /locus_tag="RVR_RS06325"
                     /protein_end="207"
                     /protein_start="56"
                     /score="45.9"
                     /tool="antismash"
                     /translation="PVVLVHGTFANGTDNWLAFAPYLVARGYCVFSLDYGMLPGENLIG
                     GLGPIADSAQQLSDFTDRVLAATHASKVDIVGHSQGGMMPRYYLQFLGGASKVNALVAL
                     APDNHGTTLDGLTALLPYFPGASDFLQDDLPGLADQVAGSDFQRELN"
     misc_feature    9839..9854
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     misc_feature    complement(9840..9853)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     misc_feature    9900..9917
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.07"
                     /tool="antismash"
     misc_feature    complement(9902..9919)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.6"
                     /tool="antismash"
     misc_feature    complement(9908..9921)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.54"
                     /tool="antismash"
     misc_feature    complement(9914..9923)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.32"
                     /tool="antismash"
     gene            complement(10001..11029)
                     /locus_tag="RVR_RS06330"
                     /old_locus_tag="RVR_1790"
     CDS             complement(10001..11029)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.4"
                     /locus_tag="RVR_RS06330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1790"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_202232904.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.7e-58, bitscore:
                     196.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELGPEPLTVLSPPADAVADGCAVEMAALLLGHLESVCASDDRLG
                     ALMRHALLPGGKLLRPLLLLESVAALGGDPGAALPAAAALEMLHAATLVHDDIIDQDAL
                     RRGRPSVAARFGQADALVGGDAMMCAALGQARALASSGYGADRALRVLEVISTAAIEVS
                     RGQMMEADLAGRMDCAMAQYLRMVRLKTGALLDAATRTAAVLTGAEPSHARALARFSDH
                     LGVAFQMQDDLLPYTDDGRAAGKPALSDLRNRRPTLPVLIAFADAAPRQRLLLQDLWRR
                     PAEDAQHALAELLEAGGALGAARATAADHLAVALAALEELPPGCHRDHLAAMAARLAAR
                     RS"
     misc_feature    complement(11442..11457)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.16"
                     /tool="antismash"
     misc_feature    11443..11456
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.97"
                     /tool="antismash"
     gene            11507..14974
                     /gene="dnaE"
                     /locus_tag="RVR_RS06335"
                     /old_locus_tag="RVR_1791"
     CDS             11507..14974
                     /EC_number="2.7.7.7"
                     /GO_component="GO:0009360 - DNA polymerase III complex
                     [Evidence IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /gene="dnaE"
                     /gene_functions="other (smcogs) SMCOG1194: DNA polymerase
                     III subunit alpha"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018837384.1"
                     /locus_tag="RVR_RS06335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1791"
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="WP_202232905.1"
                     /transl_table=11
                     /translation="MAGFAHLHVASGYSERYGAAHPEQLALRAAERGMEALALTDRDTV
                     TGIVRFAQACTQTGVRPVFGIDLAVAGLLPPPPARRTRTPVRGGAHVVEPPLRFVLLAR
                     DREGWARLCRITSAAHVGTASRAAPVQVSWDALREHGGAGLTVLLGPLSEPVRALAAGR
                     EDVAARLLRPWQEVFGDGVRLEAAVHGRSGTGPGSLRLAARTLALADRTRTPAVLTNAV
                     RYADPAQHRLADVLDAARLLRPIDRRRLDGGQRWLKGEEEMARVARQVAECAGDDPRRA
                     DRLLADTVATAAACRLDPKADLGLGARHFPEPAVVGAGPGPGAGARLLRERCAAGLARR
                     GLERDGKALDRMDRELGIIGKLGYDSYFLAVGQAVADIRELGIRVAARGSSAGSMVCHA
                     LGIATANPLDHHLLFERFLSERRRSLPDIDIDVESMRRLECYDAIFRRFGHERVAVTAM
                     PETYRARRALRDTGLALGIPPAEVDRVAKSFPHLRACDITSALAELPELRALAAEAGRY
                     GPLWELAEGLDSLVHGMAMHPCGVIISDATLLDRLPVQPTPQGDYPMAMAAKEEVEALG
                     NIKLDVLAVRMQSSMAHAVTEIERATGKRIDLDDGRQVPLDDVFAFRLIQESRTIGMFQ
                     LESPGQQDLLSRLQPRDVQDVIADISLFRPGPVQGGMPERYIAARHGGVPHFAHRALEP
                     VLADTYGVTIWHEQVIETLHVMTGCGKDRAEMGRRLLGDKERLPGIRDWFHRAAAARGF
                     SPEVREEVWATVEAFGAYGFCRAHAVAFAVPALQSAWLKAHYPAFLLAGLLEHDPGMWP
                     KRVIVADARRMGVPVLPVDVNRSRPEHVVERAGDGRWGVRLALSGVRGIGEEECARIAA
                     GQPYGSLSDFWQRARPSRPVAEQLAGIGALHALHDGRLTRRDLLLQIAELHRQSRHRNA
                     AEGQLPLTADAIGATEPAGLPEMTGREMLGAELHTLGIDVSRHLMEYHHRLLREVGATD
                     SVHLADLPAGRQVLVAGIRSATQTPPIASGKRIIFVTLEDGSGLVDLAFFEDSHERCAH
                     TVFHSGLLLVRGTVQVRGTRRTIVGTMAWDLEEVAATRRDDGPEAALALLGADGPHPTP
                     AQPQPQPQRTLENGTTGARLHPYADLQPAGSRTADLRRLGHRSPGSAG"
     gene            14971..16029
                     /locus_tag="RVR_RS06340"
                     /old_locus_tag="RVR_1793"
     CDS             14971..16029
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019059277.1"
                     /locus_tag="RVR_RS06340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1793"
                     /product="ImpB/MucB/SamB family protein"
                     /protein_id="WP_202232906.1"
                     /transl_table=11
                     /translation="MRPRHIAHLHLLADSLGEEGYAQVLEVLSGLTPHVQAFPPDAVQL
                     DLTSALRYFDRGPYDIVQMARLRIAALYGVRTSAGLARNPMLAAMAAAASPPGRTTRVP
                     GDQEAVDAWLGPMPVVTLPGVGRATAATLGMYGLYTIGQVAGVPAATLQRILGAAPARL
                     LAERVRGNDPRPVTPQAPAAHLTADLALDRDCLDPLHHRRAVIGLVEDLGHRLRTGDRV
                     TGRLTLTLRYADRSATTRTRTLPEPTAHSPLLAASALDVLASLGLQRARVRGYCLTADS
                     LLATTDATRQLSLDAADARARAAEAAADRARRRFGPGAVSPAILAGRTGPGGSGGSGGP
                     SGSGDPGGLLRR"
     misc_feature    16109..16122
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            16202..16666
                     /locus_tag="RVR_RS06345"
                     /old_locus_tag="RVR_1795"
     CDS             16202..16666
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719062.1"
                     /locus_tag="RVR_RS06345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1795"
                     /product="PPOX class F420-dependent oxidoreductase"
                     /protein_id="WP_202232907.1"
                     /transl_table=11
                     /translation="MHQAPATSPLLDLLKEQRNGVLVTLKKDGRPQLSNVTFLYDESTR
                     LIRVSATDSRAKTRNLRRDPRASFYVTTPDLGAYLVAEGEAELTPVAADPHDATVDELV
                     EIYRAIAGEHPDWEEYRAAMVADGRLVIRLRADRAYGWGRTQGGTSGALD"
     gene            complement(16683..17660)
                     /locus_tag="RVR_RS06350"
                     /old_locus_tag="RVR_1796"
     CDS             complement(16683..17660)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020139406.1"
                     /locus_tag="RVR_RS06350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1796"
                     /product="YafY family protein"
                     /protein_id="WP_202232908.1"
                     /transl_table=11
                     /translation="MLETSARLLRLLSLLQSRRDWRGPELAARLEVTARTVRRDVERLR
                     TLGYPVHAAPGTAGGYRLGAGAALPPLLLDDEEAVAVALCLRTGAVGGVEGIEETSGRA
                     LTKLEQVLPSRLRHRVQAMQAVTVGPAPAATTVSQEVLTVIGAACRDREQLRFDYLDHR
                     GTGSRRTVEPYRLVHHGRRWYLLAFDTDRDDWRTFRVDRIEPRPPTGPRFAPRGLPDDA
                     ASYVAEGVTSRAYRYQARVVLHAPLDAIASLAWSGFGRLTALGPDACELTTGFESLDAV
                     AMFIGMTGAEFEVKEPPELVSHLAAVSGRLARAARRTAGDGGAP"
     misc_feature    complement(17643..17659)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 18.82"
                     /tool="antismash"
     gene            complement(17750..19006)
                     /locus_tag="RVR_RS06355"
                     /old_locus_tag="RVR_1797"
     CDS             complement(17750..19006)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558939.1"
                     /locus_tag="RVR_RS06355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1797"
                     /product="DUF5685 family protein"
                     /protein_id="WP_202232909.1"
                     /transl_table=11
                     /translation="MFGIIRPCRHRMSEGMAASWLAHLCGLCLALRDGHGQFARVATNY
                     DGLVISVLVEAQTASTAGRRRTAGPCPLRGMRTAPVARGEGARLAAAVSLVLASAKVRD
                     HVDDGDGAFARRPVALAARRVARRWDRAGARTGGALGFDTALLLDAVGRQSEVEAAAGP
                     GSCVLAVTEPTETATAAAFAHTAVLAGRPGNTAPLQEAGRLFGRLAHLLDAVEDLAEDA
                     RTGAWNPLAATGTDLAEARRLCDDARHGIRLALRDVDFADTASARLAHTLLVHELERSV
                     DRVFGTDGCSHGPSARDGDRYTGDPYTGSPYAPGAPGQRPYPPGQPGGPAGPGGFPPPP
                     EPPRRRGLLSGCLVYTGMCCTCRLCCTDHQDAWTGRPRDAWCTSCDCGDCGDCSGCGDC
                     CQCAECCGDCDCCDCGCDC"
     misc_feature    complement(19316..19325)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.41"
                     /tool="antismash"
     misc_feature    19362..19376
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            19423..19866
                     /locus_tag="RVR_RS06360"
                     /old_locus_tag="RVR_1798"
     CDS             19423..19866
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017945315.1"
                     /locus_tag="RVR_RS06360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1798"
                     /product="cell division protein SepF"
                     /protein_id="WP_202232910.1"
                     /transl_table=11
                     /translation="MGSVRRASAWLGLVDDNGGEGYYDEEYADYGEGPERADTWVTDPR
                     VRVATESAEEEGRRIATVTPDGFRDARGIGELFRAGVPVIVNLTAMEPSDAKRVVDFAA
                     GLTFGLRGSIERVATRVFLLTPADYSVMNADSRRGGDGFFNQN"
     misc_feature    20393..20406
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
ORIGIN
        1 gacgttcacc gcgcgggcca ggtccgcgcc gggcaggatc acgttcgccg acttgccgcc
       61 gagttcgagc gccacccgct tgaccgcccc gccggccgcc gcgccgatct gccggccgac
      121 cgcggtggag ccggtgaacg acaccaagtc gacgtccggg tgctccgcga gcgcctggcc
      181 cgcgaccggg ccgagcccgg tgaccaggtt gaacaccccc gcgggcaggc cggcggcgtc
      241 cagcacctcc gccacaagct gggcgaccag cggggtgtcc tccgcgggct tgaggaccac
      301 ggtgcagccc gcggcgagcg cgggtgccac cttggccacc acctggtgca gcgggtagtt
      361 ccacggcgtg atggctccga ccacgcccac gggttcgtgc agcacccggg agttgccgat
      421 gcgctcctcg aaggggtgct cggcggcgag ggcggcgaac gacgccatca ccgaagtggg
      481 catgtccgcg tgcaccgcgg tggcgaaggc gggcggcgcg ccgagttcgg cggtgaccgt
      541 cgccgcgatc tcgtcgcgcc gcccggccat cagctccgcc gccgcggcca gcaccgccgc
      601 ccgcttcgcg ggttcggtcg acgcccagcc gggcagcgcc cgccgggccg cccgcaccgc
      661 cgcgtccacg tccctggcgt cccccgccgg gacatgggcg atgacctgct cggtcgccgg
      721 atcgaccacg tcgatccgcc cctcggccac cgcgggccgc cagccgccgt ccacgtacag
      781 cgcgtcgcgt ccccggtgga cgcgcgcgcc accgcctgcc gtacccgtcc tgccgtccac
      841 gctgccgccc tccggatcgc gcttcgcctg cgacgcctaa actagcgtcg atagttttat
      901 gtgaccagtg ctcgccccgc cgccctgggg cgcgcccatg tgatcggtgg ccacccgcac
      961 cgcgctcgcc ggtcccgtcg atcccgtccg accggtgccg agcggctccg acaacgacct
     1021 acccgccggt atgcgccgcc acccttcgaa tgcgggttcg ttattcgagc acagtcccga
     1081 gataggccct gaccagcact ttcacttcgg cgatgacgcg cgaatcaccc atttggccgg
     1141 tccggaaggc gagttgcagc gcggcgtcgg cggcttccac ggcgacggtc agggccagcc
     1201 gcaaccgcgg gtccgccggg tcggcggtga ggcggtcgcc gagcagttcc ggcagccggt
     1261 cggcgaggtc ctggttggtc tcgcccgggg cgctgaactc caccagcgcg aacccgggcg
     1321 cggtccgctt catggcggtg tactcgtcga ccagcacgtc gaccgcggca cgccagtccg
     1381 ccccggtgcc cggtcccgcc agccgcgccg ccgtgcggtc gaggaactcg tcgaggttgc
     1441 ggcggcccaa cgcgtcggcc atggcgcgct tgtcggagaa gaagcggtag acggaaccga
     1501 tcggcacccc cgcccgcgcc gccaccgccc gcgtgctcaa ccgctcgtag ccgacctcgt
     1561 cgagttcccg ggcacaggcg tcgaggatgc gcgagaggcg ctcggcgctg cggcgctgga
     1621 cggggacgcg gcgcagcgcg ccgcgcgcgg actccggccc gggcgcggcg ggtccggtcc
     1681 ctggccgcgg catcgcacct cccgccccgc ccgccgctcg aacgggcccg cctgctgctc
     1741 actccaccct agccaaggcc ggtccaccgc cccggcaccc gcgcaccgca cccccgccgg
     1801 tccagccggt ccgcgccccc tcggccgacc cggcccgacc gccccatccg tccgcccctc
     1861 ggccgacccg gcccgccccg tccgccacaa ccgccccaca ggcaccgcca tgaggcttgc
     1921 cgccacgatt cctatggccc agcataggaa tcacgatggc gagcggggag tggagcatgg
     1981 agctgcggga cgccgggcac ggcgacgagg gcagggacct cggctaccag ccggggttcg
     2041 gcaacgagca cagcacggag gccgtaccgg gcgccctccc cgtggggcgc aacgccccgc
     2101 agcgcgcgcc gctcgggctg tacgccgagc agctcagcgg caccgctttc accgagcccc
     2161 gggcgcacaa ccaccgcagc tggctctacc gcatccgccc gtccgccgct caccccccgt
     2221 tccaccgggt gccgaacggg gcgttgcgca gcgcgccgtt ccacgacgtg gagcccgacc
     2281 ccaaccgcct gcgctggggc cccctgccgc tgcccgacga gcccacggac ttcgtccagg
     2341 gcctggtcac cgtgggcggc aacggcgacg tgctgcgccg cgagggcatc ggcatccact
     2401 ggtacgcggc caacgcctcg atggaccgcc gggtgttctc ctcggccgac ggcgagttcc
     2461 tgatcgtccc ccaggagggc gccctgctgc tgcgcaccga actgggcgtg ctgcgcgccg
     2521 acccgggcca cgtcgcgctc gtcccgcgcg gggtccgctt ccgcgtggaa ctcctcgggc
     2581 cgaccgcccg gggctacgtg tgcgagaact acggccgccc cttccagctc ccggacctcg
     2641 gcccgatcgg cgccaacggc ctggccaacg cgcgggactt cctcgccccg gtcgccgcct
     2701 acgaggaccg ggaggaggac accgaggtcg tcaacaagtt cggcggcaac ctgtgggccg
     2761 ccgtctacga ccactcaccc ctcgacgtcg tcgcctggca cggcaaccac gtgccctacc
     2821 tctacgacct gcaccgcttc aacgtcctgg gctcgatcag ctacgaccac cccgacccgt
     2881 ccatcttcac cgtcctcacc tccccctcgg acaccccggg gctcgcgggc gcggacttcg
     2941 tggtgttcgc cccccgctgg ctggtcggcg aggacacctt ccgccccccg tacttccatc
     3001 ggaacgtgat gtcggagttc atgggactgg tcgagggcgc ctacgacgcg aaggccgagg
     3061 gcttcgtccc cggcggcgcc tcgctgcaca acatgatgtc cgcgcacgga ccggaccaca
     3121 cgacgttcga ccgggccagc accgccgagc tgcgcccgca gaaggtcgac gacggcctgg
     3181 cgttcatgtt cgagacgcgc tggccggtgg tgccgaccgg gttcgccctg ggcgccgggc
     3241 accggcagga ggggtacgac gcggtgtggg agggcctgcg gaggaacttc cgcccgtgac
     3301 gccggtgaac gccttcgccc ccgactccct ggtgctcaac cgcaggctgc cgctgtggta
     3361 ccaggtctcg cagtccctgc gcgcctcgat actgggccgg cggccggacg ccccgctgcg
     3421 gctgcccacc gaggaggacc tcgccgcgca ctacggggtg agcgtgctga ccatgcgcca
     3481 ggcgctgaag gagctggagg ccgaggggct gatatcccgg caccgcaggc gcggcacctt
     3541 catcgaaccg accgcgctgc gcggggcgcc ggtacgcctg ctcggctcgg tggacgccgt
     3601 cgtcgcccag cagtccgggg gacgtaccac ggtcctggcc cacggccccg ctcccctgcc
     3661 gcccgaggcg gccgagcact tcccggacct gaccgaggcc gtccgcttcc ggcggctgcg
     3721 ccacgacgag tccggcgaac cctccaactg ggcggagaac cacgtccgtc ccgaactcgc
     3781 cgcccgcatc gaccccgccg acctcgaacg ctggccgatg acgaagatcc tgcgcgacgt
     3841 gctgggggtg cggatcagcc gcatcaccga caccctggag gccgggctcg ccgaccccgg
     3901 caccgcccgc ctgctccggg tgccgctgct cagcccgatc ctgcactgca ccggcgtgac
     3961 ctacgacgag accggcaggg ccgtggacgt ggtccgcatc cactaccgcg gcgacaggtt
     4021 ctccttcacc gtgacgatgg aggcaccctg acgggcgtca gtagcatgcg tgtggtgagc
     4081 gatgacgcgc ctttgctgca cgacctgatg ccctggtcgg tgcgcccgct gcgcatcggc
     4141 cgcggctggc cgatggcgtc cgaacccgcc tgcctgcggg cccgctggac gctcctcacc
     4201 accgcgccgg acgaggccac cagaaacgcg ttgctgcgcc cgacccgggc ccggggcccg
     4261 cacaccccgg tcggccagct ccccggccac cccactccca ccaccgcgat cgcccgcgag
     4321 gccggccgct gcccggagcc ggtccgcgtc cagcacgggc cgttcgacca gcagtggctg
     4381 atacccgacc accggctgat cgacgtggcc cggcccgagt tgtggcggat cgccgacgac
     4441 cggcagctct tcgccgtcga acacagcccg ctgccggaca ccgcggaggc cgtggtgacc
     4501 ttcagcgcgc tgcttcccga cgggcgttcg ccggccggca ggcccgcgct gatccggccg
     4561 ctgtaccggc gccccggcgg ccgcgacccc aacctcgccc cgggcctgac cggttggctc
     4621 gcctcccgcc tggacaccgg cgtcaccgcc gaggacaccc tcgcctggat tgccgccgcg
     4681 gcccgccccg gccaccgggg ctgcgaggtg ccgctccccc gcgacctgga ccagtggcag
     4741 gaggggacgg ccctgggccg caggtcgctg tggctgcaca cccggggcgc ccgctgcgcc
     4801 gaccccgggc agggccgcga cgcgtcccgg ctgcggcctc ccgggggcag ccgcccctac
     4861 gtccgtgcgg cgctgcccga acggccccgg ccggacgacc tgcggtacga cccgcaggag
     4921 cgcgccctgt gggtcggaac cggccaggtg gctccggtgg cgcccgaggc gtgggaggcc
     4981 accgcgggcg gcgtgcgggt gctggaggcg tggtacgggc ggcggaccgc gcccggcgag
     5041 cccggctcgc tggaggccct gcgcccggcc gcctggacgc gggcgacgac ctcggaactc
     5101 ctggagctga tcggcgtgct gacgctgctg gccggtctcc gggaggaggt ggcggacttc
     5161 acggcgcggt cggcagccga gggggtcgac agggcgggtg cggccggcgc ggcggcgctg
     5221 cgggcggccg gggtccttcc ggtgcccgcg gccaggcgga ggccggcctc ggtgctggaa
     5281 caccacgagg agggcccgga cgggcagttc gccctgctgt gaccgcgcgt gtgaccgcgc
     5341 gtgcggtggt cgggctgcgg ccgctgggga ggacggccgc atgcacccca ccaccgaggt
     5401 gacagcagga cggacgcgaa ctgctcgcgg actcagcggt gattgccgaa gagcgacctc
     5461 cgcagccggc gcagcggcgc gaacagggac acccgggcgc ccttgtcggt cctgacacgc
     5521 gtggcgtcac gcgaggtcag ctcccgcagc agcacggtgg cctcctcggc ctcacgctgc
     5581 ggcactgcgg ggccggccag tatcgaaagg tgccggtcca aacgcgcact ggacgccgta
     5641 gtaccgcagt tgatggcagg cactcttggc ctgctgtgca tcgctatctg ttccatgact
     5701 ctccccaccc tgtcgagggc acccagcacg ggcagggtaa ccctatcgcc ccgtcacgtc
     5761 acgtgcgcgt cccccgtgca cccctgtcgc ccgattcacc ttccgcacaa gggggttgac
     5821 gcggtagtgc acacaaaggg gcgacgtcgc acgtcgcggc cccggccgca ccggaatcct
     5881 ttccggacac gcgtgcggcg aatcaaccct ttcgaggggt ttggaagttc acaccagggc
     5941 ccgaatcgaa ccgaaaagca ctgggcgatc gcccctccgt gccggatcat gggccccatg
     6001 tccgccacac cccgtccacc gaggaggcac gtgccgccca cctctcccgc cgccgacgcg
     6061 acggacgccg cggccgccga tccgttccgc accctgcccg tccacctgcg gctggacgac
     6121 agcgactcgc cgtccgacgt cgtcgacgcc ctgttcctgg ggcgtttcac ctcggggcgg
     6181 cagcccttcg cccgcagcag ctcgctggag aacgtcaagc ccggcctcac cctgctgccg
     6241 ccggacgcga ccgtactgcg gcaggcgcgc gacaaggacc gcagcgccct gctggccgag
     6301 ggggaggact ggacgatcct cgtctcgcgc tggagccggg gcgcggacgt cacggtgacg
     6361 gcgacctccg acgaactcgc cgagcgggtg ctgaagtcgg cggtcgagga cgcggaggac
     6421 gaaccggagc cgcagccgga gaacgtcacc atgggcttct ggtacgtctc cccccggcgg
     6481 ggcccgcacc gcacgacccg gaagatctcc gccggcacct gggacgaact gcgcggcaac
     6541 tactcggcgc cggtcgccga cgccatggac ggcctgatga agatgacggc cgacgacatc
     6601 accgggcggc tgctgctgct ccacggaccg cccggcaccg gcaagacgtc cgccctgcgc
     6661 accctggcgc gctcctggcg cgactggtgc caggtggact gcgtcctgga ccccgagcgg
     6721 ctcttcaacg acgtgggcta cctgatggac atcgccatcg gcgaggacga gagcgagggc
     6781 ggccgctggc ggctgctcct gctggaggac tgcgacgagc tgatccgcgg gcaggccaag
     6841 cacgagaccg gccaggccct gtcccgcctg ctcaacctga ccgacggcct gctcgggcag
     6901 ggccgcaacg tcctggtcgg catcaccacc aacgaggccc tggaacgcct gcacccggcc
     6961 gtcgtacggc ccggccgctg cctcgcccgc atcgaggtcg gcccgctgaa ccgggaggag
     7021 gccgtgcgct ggctcggcac cggcgagggc gtcggacgcg agggggccag cctcgccgag
     7081 ctgtacgccc tgcgccgcgg cacctcgccg accctcgccg tgccgcccca ggcggacggc
     7141 ggcctctacc tgtgacgccg gcgccggtcc accgccggcg tccgccgccc cggtccggcg
     7201 cccggaccta cccgccgtac tccgcgcgca gcgcctcctc cacggcggcg cgtgcggcgt
     7261 cacggtccag gccgaggcgg tggacccgcc gggcgtagcc ggccgcggcg tccgccacct
     7321 cgcgggccat ggcgtcgccg gccgcgacgt aggtcccgtg gcggccccgg gtctcgatca
     7381 ccccgtccgc ctccagcgcc cggtacgcct tcgcgacggt gttcgcggcg aggcccaact
     7441 gttcggccag cccccgtacg gtgggcagct tgtggtggac ggggagctcc cccgagcggg
     7501 ccttctcggc gatctggccg cgcacctgct cgtacggcgc ggcggtggcg tccggatcga
     7561 tcgtgatctt caggctcata cgccggatac tggcacagcg gccgccgcca gcggcaccgc
     7621 tcgggccggc ccgtccgggg cgtgggcgat ggagtccccg ctctcgtgca ggtggagcag
     7681 gaagcggtgg ccggccagga agccgtccac cgccgcacgg cagtaggcga ccatgtcgtc
     7741 gggcagcgcg tccagcgggt accagccgag ctcggagcac ttgtccggtt cgcggttgac
     7801 cggctcgggg ctcccggccg cgtggtgcgc gacgaagaac cagccgatcc tggcccggcc
     7861 gtcgggcgcc cggtgctgca tcaccatcgc ggcttccagg tcgccggggg ccaggtcgag
     7921 cccgatctcc tcacgggcct cgcggagcat tccgctccgg acgtcctcgc cgtcctccag
     7981 gtgcccggac ggggcgtgca gcaggccgtc cgcgtatccg gtcccgtccc ggcgggagag
     8041 cagcacctcc cggccgcgca gcaggagcag gtgcacgtcg acgatctcgg tgtgccggcg
     8101 ggcggcccgg tgcgcggggc ggaccaccgc cacgtacctc tcgtcgcgga ccgcgcgtcc
     8161 ccacagcggc gtgtcgtgtc cgagctgttc gacctggacc gacccgccga gcggagcggc
     8221 gagtcggacg agggtgtcgg ccgcgatacc ggccgggggc gtcccccacc ggccctccac
     8281 gaggaccagg cggccgccgg gccgcagcag gtccgcccac cgccgcagca cctcctcggg
     8341 gtccggcagc gcccacagga cgtggcggac gaggacgacg tcgaagccgc cggcggccac
     8401 cggcggccgg gccgcgtcgc cgacgagcac ccgcgcgcgc gtcccggaga gtttggcgcg
     8461 ggccagcgcg accatccgct ccgaccggtc caccgcggtg acgcggtgcc cgtccgcggc
     8521 cgcgaggagc gcgaggcttc cggttccgca gcccaggtcg aggacgtccg acggcccggc
     8581 gggcagccag gaccgcagcc gcgcctccca ggccgagcgc acgcccgggt cgcgcaggcc
     8641 gtggtcgggc tcgtcgtcga agtggtcggc ggcggcgtcc cagtactgcc gggcgtccgg
     8701 gtccgggccc gattccgtgc tcgtggcgtc cgtgctcatg ggaggagcct cccacctgcc
     8761 accgacagcc gggcggcccc ggaccgcccg gctccccgcc gggaatcgac gatccccccg
     8821 aggagccggc cggcccgcgg gcgaccacgg acgccgggtg cgcgtgccgg gcgtcgcggg
     8881 cccggcacgt tccgccggac agggcctgac cggctagctc gccgccgaca ggcaggtggt
     8941 ccgggtggcg tgcgcgggat cgagcgcgtt ggccgcctcg tggaacgcga tgcggtcggt
     9001 caggccgatg gcgacgtgtt cggagacgtc gagcgggcag aggtcctgga gcaccacgtt
     9061 gtggacgttg ggcccggaca gtgcctgcgt ggtgtagggg gtgacgacct cgtcgtagat
     9121 ggtggagatc acggtgtact gcacgccggg caccgtgtcg ccgcccgcgt tcagttcacg
     9181 ctggaagtcc gagccggcca cctggtcggc caggccggga aggtcgtcct ggaggaagtc
     9241 ggacgcgccg gggaagtacg gcagcagcgc ggtcagcccg tccagcgtgg tcccgtggtt
     9301 gtcgggggcg agggcgacca gtgcgttcac cttggacgcg ccgccgagga actgcaggta
     9361 gtagcgcggc atcatgccgc cctgggagtg gccgacgatg tcgaccttgg acgcgtgggt
     9421 ggccgccagc acccggtcgg tgaagtcgga gagctgctgc gccgagtcgg cgatcggccc
     9481 cagcccgccg atcaggttct cgccggggag catgccgtag tcgagcgaga agacgcagta
     9541 gccgcgcgcc accaggtagg gggcgaaggc gagccagttg tcggtgccgt tggcgaaggt
     9601 gccgtgcacc aggacgacgg gccgggggtg ttgggcggag gggcggcagg agtagttgtt
     9661 ccagccgctg gtcggcgcgg agccggcaga cgcggagccg gtggacgcgg aggcgacggc
     9721 cgtgggcgcg accgccatcg cggtcgtcag ggcgaacacg gccaggagcc gtctccagga
     9781 cagcctcatg ggaactcctc acagggaagc gggggcgcga caacgacacc cggcagcctg
     9841 tgatccggat cactttgctg ggctcatgac aagttacgca cgagtaggaa gccgctgact
     9901 agttacgcgt gagtaaaaaa tggcgcaccc gccgcatcgg ccctcccgcg agggcgttca
     9961 agccggacgc gggtcggacg cgggcgggct cgggccgggc tcaggaccgc cgggcggcca
    10021 gacgtgcggc catggccgcg aggtggtcgc ggtggcagcc ggggggcagc tcctccagcg
    10081 cggccagcgc gacggcgagg tggtccgcgg cggtggcccg ggcggcaccc agcgccccgc
    10141 cggcctccag gagttcggcc agggcgtgct gggcgtcctc cgccggccgc cgccacaggt
    10201 cctgcaacaa caggcgctgc cggggggccg cgtcggcgaa ggcgatcagc acgggcaggg
    10261 tcgggcgccg gttgcgcagg tcgctgagcg cgggcttgcc ggccgcccgg ccgtcgtcgg
    10321 tgtacggcag caggtcgtcc tgcatctgga aggcgacgcc gaggtggtcg gagaaccggg
    10381 ccagcgcccg ggcgtgcgac ggttctgcgc cggtcagcac ggcggcggtg cgggtcgcgg
    10441 cgtcgagcag cgcgcccgtc ttgagccgga ccatccgaag gtactgcgcc atggcgcagt
    10501 ccatgcgccc ggccaggtcg gcctccatca tctggccccg gctgacctcg atcgcggccg
    10561 tgctgatcac ctccagcacc cgcagggccc ggtcggcgcc gtagccgctg gaggccaggg
    10621 ccctggcctg tccgagcgcg gcgcacatca tggcgtcccc gcccaccagg gcgtcggcct
    10681 ggccgaaccg cgcggccacg ctggggcgac cgcgccgcag cgcgtcctgg tcgatgatgt
    10741 cgtcgtgcac gagcgtggcg gcgtgcagca tctccagggc cgcggcggcg ggcagcgccg
    10801 cacccgggtc accgccgagg gccgcgacgg actccaggag gagcagcggg cgcagcagct
    10861 tcccgccggg cagcagggcg tggcgcatca gcgcccccag ccggtcgtcc gaggcgcaca
    10921 cggactccag gtgcccgagc aggagcgcgg ccatctccac ggcgcagccg tccgcgacgg
    10981 cgtcggcggg cggggagagc accgtcaggg gctcggggcc gagttccacg ccaccgcgca
    11041 cactccacca gctctcgggc aggacggacg acaggatcca cgcgcccgcc ctccggcacg
    11101 acgaaccggg cgcaggccga cgagcggcag atacccacac aatatgccga ccgtgtggag
    11161 cggctgccag cgccccatgg atggcgtggg cggcgggcgg ccggcgggcg cgttcggatc
    11221 gccgcgcctc ggcgtcgcgg cgcggccggc cgcggccggg ccgtgccgtg ccgtgaggaa
    11281 cgtcatggcg gtcggcggcg ccgcgccgcg tgccgccaag tccgttgccg gaccgcggag
    11341 atgccgcgcg ggcgttcgat ccggccaccg cctcccgcgg tcccgtccgt ccgacgcggg
    11401 cgcgttcgag tcgctgacct ggggcgaccg cgctaagcta atcgaacgaa cgtacgagga
    11461 acgttccggg tggatggccg aaaaggggtg gagcgggagg tgcggcatgg cgggcttcgc
    11521 ccatctgcat gtcgcgtccg gctactccga gcggtacggc gccgcgcacc ccgaacagct
    11581 cgcgctgcgg gccgccgagc gcggcatgga agcgctggcg ctgaccgacc gggacaccgt
    11641 gaccgggatc gtccgcttcg cgcaggcgtg tacgcagacg ggggtgcggc cggttttcgg
    11701 gatcgacctc gccgtggcgg gccttctgcc gccgcccccg gcgcggcgga cgcggactcc
    11761 ggtgcgcggc ggcgcccacg tggtcgagcc gccgctgagg ttcgtgctgc tggcccgcga
    11821 ccgggagggc tgggcgcggc tgtgccggat caccagcgcc gcccacgtgg ggacggcgag
    11881 ccgcgccgcg cccgtacagg tgtcgtggga cgcgctgcgc gagcatggcg gtgccggtct
    11941 gaccgtcctg ctcggaccgc tctcggagcc ggtgcgggcg ctggcggccg gacgggagga
    12001 cgtcgcggcg cggctgctgc gcccctggca ggaggtcttc ggtgacgggg tgcgcctgga
    12061 ggcggccgtc cacggccggt ccggaaccgg tccgggctcc ctgcggctgg ccgcccgtac
    12121 cctcgcgctc gccgaccgga cccgtacgcc cgcggtgctg accaacgccg tccgctacgc
    12181 cgacccggca cagcaccgcc tcgccgacgt cctggacgcc gcccggctgc tgcggcccat
    12241 cgaccggcgc cggctggacg gcggacagcg ctggctcaag ggcgaggagg agatggcacg
    12301 cgtcgcgcgg caggtcgccg agtgcgccgg cgacgacccg cgccgggccg accggctgct
    12361 cgccgacacc gtcgccaccg cggcggcctg ccgcctcgac ccgaaggcgg atctcgggct
    12421 gggggcccgg cacttccccg agccggcggt cgtcggcgcc ggcccgggcc ccggcgccgg
    12481 tgcccggctg ctgagggagc gctgcgcggc gggtctggcc cgccgcggcc tggagcggga
    12541 cgggaaggcg ctggaccgga tggaccgtga gctggggatc atcgggaagc tgggctacga
    12601 ctcgtacttc ctcgccgtgg ggcaggccgt ggccgacatc cgcgagctgg gcatcagggt
    12661 cgccgcccgc ggttccagcg cgggctcgat ggtctgccac gccctcggca tcgccaccgc
    12721 caacccgctc gaccaccacc tgctgttcga acgcttcctc agcgagcggc gccgaagcct
    12781 gccggacatc gacatcgacg tggagtcgat gcgccggttg gagtgctatg acgcgatctt
    12841 ccgccggttc ggccacgagc gggtcgcggt caccgcgatg cccgagacct accgggcgcg
    12901 cagggcgctg cgcgacacgg gactggcgct cggcatcccc ccggcggagg tggaccgcgt
    12961 cgccaagagc ttcccgcacc tgcgggcctg cgacatcacg agcgcgctcg ccgagctgcc
    13021 cgaactgcgc gccctcgccg ccgaggccgg acggtacggg ccgctgtggg agctggccga
    13081 ggggctggac tccctcgtcc acggcatggc catgcacccg tgcggagtga tcatcagcga
    13141 cgcgaccctg ctggaccgcc tccccgtcca gccgaccccc cagggcgact accccatggc
    13201 catggcggcc aaggaggagg tcgaggccct gggcaacatc aagctggacg tcctggccgt
    13261 acggatgcag tcctcgatgg cgcacgcggt caccgagatc gaacgcgcca ccgggaagcg
    13321 gatcgacctc gacgacggga ggcaggtccc gctggacgac gtcttcgcct tcaggctgat
    13381 ccaggagagc cggaccatcg gcatgttcca gctcgagtcg cccggccagc aggatctgct
    13441 ctcccgcctg caaccgcggg acgtgcagga cgtcatcgcc gacatcagcc tcttccgccc
    13501 cggcccggtc cagggcggca tgcccgagcg gtacatcgcc gcccggcacg gcggcgtccc
    13561 gcacttcgcc caccgcgccc tcgaacccgt cctcgccgac acctacgggg tgaccatctg
    13621 gcacgagcag gtcatcgaga cgctgcacgt gatgaccggg tgcggaaagg accgggcgga
    13681 gatgggccgg cgcctgctcg gcgacaagga gaggctgccg gggatccggg actggttcca
    13741 ccgcgccgcc gccgcccgcg gcttctcccc cgaggtgcgc gaggaggtgt gggcgacggt
    13801 cgaggccttc ggcgcctacg ggttctgccg ggcccacgcc gtcgccttcg ccgtgcccgc
    13861 cctgcagtcc gcctggctga aggcgcacta cccggcgttc ctgctggccg gtctgctgga
    13921 gcacgacccg ggcatgtggc ccaagcgcgt catcgtcgcc gacgcccgcc gcatgggagt
    13981 gcccgtgctg ccggtcgacg tcaaccgctc ccgtccggag cacgtcgtcg agcgggccgg
    14041 ggacggccgg tggggggtgc ggctcgcgct gtccggggta cgcgggatcg gtgaggagga
    14101 gtgcgcgcgg atcgccgccg ggcagcccta cggatcgctg tccgacttct ggcagcgggc
    14161 ccggcccagc cgcccggtgg ccgaacagct cgccgggatc ggggccctgc acgcgttgca
    14221 cgacgggcgg ttgacccggc gggacctgct gttgcagatc gccgagctgc accggcagtc
    14281 ccgccaccgg aacgcggccg aggggcagct cccgctcacc gccgacgcga tcggcgcgac
    14341 cgagcccgcc gggctgcccg agatgaccgg acgcgagatg ctcggcgcgg aactgcacac
    14401 gctcggcatc gacgtctccc ggcacctgat ggagtaccac caccggctgc tgagggaggt
    14461 cggcgcgacc gactccgtcc acctggccga cctgcccgcg ggccgccagg tgctcgtggc
    14521 cggcatccgc tccgcgaccc agacccctcc gatcgcctcc ggcaagcgga tcatcttcgt
    14581 caccctggag gacggctccg gcctggtcga cctcgccttc ttcgaggact cccacgagcg
    14641 ttgcgcccac acggtcttcc attccgggct gctgctggtc cgcggcaccg tccaggtccg
    14701 cggcacccgc cggacgatcg tcggcaccat ggcctgggat ctggaggagg tcgccgccac
    14761 ccggcgggac gacggccccg aggccgctct cgcgctcctg ggagcggacg gcccccaccc
    14821 gacaccggcg cagccgcagc cgcagccgca gcggaccctg gagaacggca ccaccggcgc
    14881 ccgcctccac ccctacgccg acctccagcc ggccggctcc cgcaccgccg acctgcgcag
    14941 gctcggccac cgcagcccgg ggagcgcggg atgaggccgc gccacatcgc ccacctccac
    15001 ctgctcgccg acagcctcgg cgaggagggc tacgcgcagg tgctggaggt gctgagcggc
    15061 ctcacccccc acgtccaggc gttcccgccc gacgcggtgc agctcgacct gacctcggca
    15121 ctgcgctact tcgaccgcgg cccctacgac atcgtgcaga tggccaggct gcggatcgcc
    15181 gccctgtacg gcgtccggac cagcgcggga ctggccagga acccgatgct ggcggccatg
    15241 gcggcggccg cctccccgcc cggccgcacc acgcgcgtcc ccggcgacca ggaggcggtg
    15301 gacgcctggc tgggaccgat gccggtggtc acgctgcccg gggtcggccg ggccaccgcg
    15361 gccacgctcg gcatgtacgg gctgtacacc atcggccagg tcgcgggcgt ccccgcggcc
    15421 accctccagc ggatcctggg cgccgccccc gcccggctgc tcgccgaacg cgtccgcggc
    15481 aacgaccccc gcccggtcac gccgcaggct cccgcggcgc acctgaccgc cgacctcgcg
    15541 ctcgaccgcg actgcctcga tcccctgcac caccgccgcg ccgtgatcgg gctggtcgag
    15601 gacctcggcc acaggctgcg gaccggggac cgggtcaccg gccgcctcac gctcaccctc
    15661 cggtacgccg accggagcgc caccacccgg acccgtacgc tgcccgaacc caccgcccac
    15721 tcacccctgc tggccgcctc cgccctggac gtcctggcct ccctgggcct gcaacgcgcc
    15781 cgggtgcgcg gctactgcct gaccgccgac agcctgctgg ccaccaccga cgccacccgc
    15841 caactcagcc tcgacgccgc cgatgcccgc gcccgcgccg ccgaagccgc cgccgaccgg
    15901 gcccgccgcc gcttcggacc gggcgcggtg agccccgcga tcctggccgg gcgcaccgga
    15961 cccggcgggt caggcgggtc aggcgggcca agcggttccg gcgatccggg cggtctcctc
    16021 cggcggtgag ttcggtgcgg acgccgcccc accggcccga cctcgggtcc ccgtccactc
    16081 ggacgagtga atccgtgcgg atcggcgttc gagccggaac aagggtcggt cacggtgcgt
    16141 tctccccacc acaggcagta accgaccggt atccgtcagc acccctccac caggagcgat
    16201 catgcaccag gcccccgcca ccagcccgct gctggacctg ctcaaggaac agcggaacgg
    16261 cgtgctcgtc accctcaaga aggacggccg cccccaactg tccaacgtca cgttcctcta
    16321 cgacgagtcg acccgcctca tccgggtctc cgccaccgac agccgggcca agacccgcaa
    16381 tctgcgccgc gacccgcggg cgagcttcta cgtcacgacc ccggacctgg gggcgtacct
    16441 ggtcgccgag ggcgaggcgg agctgacccc ggtggccgcc gacccgcatg acgccaccgt
    16501 cgacgaactg gtcgagatct accgggcgat cgccggggag cacccggact gggaggagta
    16561 ccgcgcggcg atggtggccg acgggaggct ggtcatacgc ctgcgggccg atcgtgccta
    16621 cggatggggc cgcacccagg gcggcacgag cggcgctctg gactgagcgg gcccgcccgg
    16681 ggtcaggggg cgccgccgtc cccggccgtg cggcgggccg cgcgggccag ccggccggac
    16741 accgccgcga ggtgggacac cagctcgggc ggctccttca cctcgaactc cgcgcccgtc
    16801 atgccgatga acatcgccac cgcgtccagc gactcgaacc cggtggtcag ttcgcaggcg
    16861 tcgggcccga gcgcggtgag ccggccgaag ccggaccagg cgagggaggc gatggcgtcc
    16921 agcggcgcgt gcagcaccac ccgggcctgg tagcggtagg cccgtgaggt gacgccttcg
    16981 gcgacgtagg aggcggcgtc gtcggggagt ccacgcgggg cgaaccgcgg accggtgggc
    17041 ggcctgggct cgatccggtc cacccggaag gtccgccagt cgtcccggtc ggtgtcgaac
    17101 gcgaggaggt accagcgccg gccgtggtgg accagccggt agggctcgac ggtgcggcgg
    17161 ctcccggtgc cgcggtggtc gaggtagtcg aagcgcagtt gctcgcggtc ccggcaggcg
    17221 gccccgatga cggtcagcac ctcctggctg accgtcgtcg cggccggcgc ggggcccacg
    17281 gtgaccgcct gcatcgcctg cacccggtgc cgcagccgtg acgggaggac ctgctccagc
    17341 ttggtcagcg cccgccccga ggtctcctcg atgccctcga cgccgccgac cgcgcccgtc
    17401 cgcaggcaca gcgccaccgc gacggcctcc tcgtcgtcga gcagcagcgg cggcagggcg
    17461 gctcccgcgc ccagccggta gccgccggcc gtgccgggcg cggcgtggac gggatagccg
    17521 agcgtgcgca ggcgttcgac gtcccgccgg accgtgcggg cggtgacctc caggcgcgcg
    17581 gcgagttcgg gccccctcca gtcacggcgc gactggagga gggagagcag gcgcagcagg
    17641 cgcgccgacg tttccagcat gcgtgcagtc tggcagcggg ccgggacagg aggcggccgc
    17701 gcaccggtcg gccgcggggg ctcaggccgt ggggctcagg ccgcggggct cagcagtcgc
    17761 acccgcagtc gcagcagtcg cagtccccgc agcactcggc gcactggcag cagtcgccgc
    17821 aaccgctgca gtccccgcag tccccgcagt cgcacgaggt gcaccaggcg tcgcggggcc
    17881 ggccggtcca ggcgtcctgg tggtcggtgc agcacagtcg gcaggtgcag cacatgcccg
    17941 tgtagaccag gcatccggac agcagcccgc gccggcgcgg cggctcgggc gggggcggga
    18001 aaccgccggg accggccggt ccgcccggct gcccgggcgg gtagggccgc tggccgggcg
    18061 caccgggcgc gtaggggctg ccggtgtacg ggtcgccggt gtaccggtcg ccgtcccgtg
    18121 ccgacgggcc gtgcgagcag ccgtcggtgc cgaacacccg gtccacggag cgttccagtt
    18181 cgtggacgag cagggtgtgg gccaggcggg cggaggcggt gtcggcgaag tcgacgtccc
    18241 gcagggcgag ccggatgccg tgccgggcgt cgtcgcacag ccggcgggcc tcggcgaggt
    18301 cggtgccggt ggcggcgagc gggttccagg cgccggtgcg ggcgtcctcg gccaggtcct
    18361 cgaccgcgtc gaggaggtgg gcgaggcggc cgaacagccg cccggcctcc tggagcgggg
    18421 cggtgttgcc gggccgcccg gcgaggactg cggtgtgggc gaaggccgcg gcggtcgcgg
    18481 tctcggtggg ctcggtgacg gccagcacgc aactgccggg tccggccgcc gcctcgacct
    18541 cgctctgccg tccgaccgcg tcgagcagca gggcggtgtc gaagccgagg gcaccgccgg
    18601 tgcgcgcgcc ggcccggtcc cagcggcggg cgacccggcg ggccgcgagc gcgaccgggc
    18661 gccgggcgaa cgccccgtcc ccgtcgtcga catggtcgcg caccttcgcc gacgccagca
    18721 ccagcgagac cgccgcggcc aggcgggccc cctcgcccct ggcgaccggc gcggtgcgca
    18781 tgccgcgcag cgggcagggc cccgcggtgc ggcgccgacc ggcggtggac gcggtctgcg
    18841 cctcgaccag gacggagatc accagaccgt cgtaattggt ggcgacacgg gcgaactggc
    18901 cgtgtccgtc gcgcagggcg aggcacagcc cgcacaggtg ggcgagccag gacgcggcca
    18961 tgccctccga catccggtgc cggcacggcc gaatgattcc gaacacgctt cccactcccc
    19021 catcggaccg cggtgcgccg acgcggtgcc ttgaggcgac gcgtggggcg gaggcggcgt
    19081 gtgggccgcc ccgggtcgtg cccggccgcc acgcgcccgc catcaccagc gctttgacct
    19141 tcggtcaggt ttcagaaccc ggtcggcggt catgttatcg gtgcggcacc ccgcttccgt
    19201 acggccgtac ggcccccgaa atcacccgat cgtggaggac gttcccatca cgtcgtcagg
    19261 tctccgatgc ctgcccctgc ttgacggtgc gccactatcg tgtgtgccag taccgtcaca
    19321 aagcacctgc gtggcgcgta tccccttggc gcatcaccct catcatggat gacgatagga
    19381 ctaagcggac ggtacagacc gcgtgcgaga gaggaggcgt ccatgggttc tgttcgacgg
    19441 gcgagtgcct ggcttggcct cgtcgacgac aacggcggcg agggttacta cgacgaggag
    19501 tacgccgact acggcgaggg cccggagcgc gccgacacgt gggtgaccga cccgcgggtt
    19561 cgggtcgcca ccgagtcggc cgaggaagag ggccggcgga tcgccacggt gacgcccgac
    19621 ggcttccgtg acgcgcgcgg catcggcgag ctcttccgcg ccggcgtccc ggtgatcgtc
    19681 aacctcaccg cgatggagcc ctccgacgcc aagcgcgtgg tcgacttcgc cgccgggctg
    19741 accttcggcc tgcgcggctc catcgagcgg gtggccaccc gggtgttcct gctcaccccg
    19801 gccgactact ccgtgatgaa cgccgactcc cgccgcggcg gcgacggctt cttcaaccag
    19861 aactgagtcc ggccccggcc gcgcgcccgc cgctccccgc ggccgcgcac cggccggtgc
    19921 cggcggccgc caccgccttc cgcgggcaac gcctcacccg cggaaggcgt cgatcccggt
    19981 gagcgccttg cccagcacga gctggtgcat ctccacggtg ccctcgtagg tcagcacgga
    20041 ctccaggttg gtcgcgtgcc gcatcaccgg gtactccagc gagatgccgt tggcgcccag
    20101 gatcgtgcgc gcggtgcggc agatctcgat cgcctcgcgc acgttgttga gcttgccgaa
    20161 gctgacctgc tccgggcgca gcgtgcccgc gtccatccgc tgcccgaggt ggtgcgccag
    20221 caggatcccc ttgtggagtt cgaccgccat gtcggccagc ttggcctggg tgagctggaa
    20281 gcccccgatc ggccgtccga actgctcacg ctcgcccgcg tacgccagcg ccgcctcgaa
    20341 actggaccgt gccgcgccca tcgcgcccca cacgatgccg tagcgcgcgt ggttgaggca
    20401 gctcagcgga ccgcgcaggc cggtgacctc gggcagcacc gcgtccgcgg gcagccgtac
    20461 gccgtccagc accagttcgc tggtgaccga ggcgcgcagg ctccacttgt ggcggatctc
    20521 gggtgcggag aacccggggg cgtcggtggg gacgacgaag ccgcgcaccc cctcctccgt
    20581 cgcggcccag accacggcca ccccggcgac cgagccgttg gtgatccaca tcttgcggcc
    20641 gtcgagcacc cagtccgagc cgtcccggac cgcgcgggtg cgcatgccgg ccgggtcgga
    20701 gccgtggtcg ggctcggtca gcccgaagca gccgatcacc tcgcccgcgg ccatcgacgg
    20761 cagccagcgc tccttctggg cgtcggagcc gaagcggtgg acggcgtaca tggcgagcga
    20821 accctgcacc gacaccagtg agcggatgcc ggagtcggcg gcctccaact ccaggcaggc
    20881 caggccgtac tgcaccgcgc tcgcgcccgc gcagccgtaa ccgtccagtt gcatgccgag
    20941 ggcgccgatg gagccgagtt cgcgggccag ttcgcggacc tcgggcagct cgccgcgctc
    21001 gtaccagccc gccacgtggg gcagcaccc
//
