LOCUS       NZ_AP018365            21029 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  Streptomyces sp. SN-593 chromosome.
ACCESSION   NZ_AP018365
VERSION     NZ_AP018365.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. SN-593
  ORGANISM  Streptomyces sp. SN-593
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Panthee,S., Kito,N., Hayashi,T., Shimizu,T., Ishikawa,J.,
            Hamamoto,H., Osada,H. and Takahashi,S.
  TITLE     beta-carboline chemical signals induce reveromycin production
            through a LuxR family regulator in Streptomyces sp. SN-593
  JOURNAL   Sci Rep 10 (1), 10230 (2020)
   PUBMED   32576869
  REMARK    DOI:10.1038/s41598-020-66974-y Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Takahashi,S., Toyoda,A., Sekiyama,Y., Takagi,H., Nogawa,T.,
            Uramoto,M., Suzuki,R., Koshino,H., Kumano,T., Panthee,S., Dairi,T.,
            Ishikawa,J., Ikeda,H., Sakaki,Y. and Osada,H.
  TITLE     Reveromycin A biosynthesis uses RevG and RevJ for stereospecific
            spiroacetal formation
  JOURNAL   Nat Chem Biol 7 (7), 461-468 (2011)
   PUBMED   21642985
  REMARK    Publication Status: Online-Only
REFERENCE   3
  AUTHORS   Panthee,S., Takahashi,S., Takagi,H., Nogawa,T., Oowada,E.,
            Uramoto,M. and Osada,H.
  TITLE     Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds
            from Streptomyces reveromyceticus SN-593
  JOURNAL   J. Antibiot. 64, 509-513 (2011)
REFERENCE   4
  AUTHORS   Takahashi,S., Takagi,H., Toyoda,A., Uramoto,M., Nogawa,T., Ueki,M.,
            Sakaki,Y. and Osada,H.
  TITLE     Biochemical characterization of a novel indole prenyltransferase
            from Streptomyces sp. SN-593
  JOURNAL   J Bacteriol 192 (11), 2839-2851 (2010)
   PUBMED   20348259
REFERENCE   5  (bases 1 to 8833490)
  AUTHORS   Takahashi,S., Ueki,M., Toyoda,A., Ishikawa,J., Sakaki,Y. and
            Osada,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2017) Contact:Shunji Takahashi Chemical Biology
            Research Group, RIKEN Center for Sustainable Resource Science
            (CSRS); Hirosawa 2-1, Wako, Saitama 351-0198, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Phrap v. 0.990329
            Genome Coverage                   :: 16x
            Sequencing Technology             :: ABI 3730
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016756395.1-RS_2024_05_21
            Annotation Date                   :: 05/21/2024 03:58:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,420
            CDSs (total)                      :: 7,334
            Genes (coding)                    :: 7,181
            CDSs (with protein)               :: 7,181
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 153
            CDSs (without protein)            :: 153
            Pseudo Genes (ambiguous residues) :: 0 of 153
            Pseudo Genes (frameshifted)       :: 35 of 153
            Pseudo Genes (incomplete)         :: 136 of 153
            Pseudo Genes (internal stop)      :: 8 of 153
            Pseudo Genes (multiple problems)  :: 25 of 153
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:29:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1216731
            Orig. end                         :: 1237760
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP018365.1.
            This work was done in collaboration with Shunji Takahashi, Masashi
            Ueki, Atsushi Toyoda, Yoshiyuki Sakaki and Hiroyuki Osada (RIKEN)
            and Jun Ishikawa (National Institute of Infectious Diseases).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21029
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21029
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21029
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11029](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11029
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            703..1890
                     /locus_tag="RVR_RS05135"
                     /old_locus_tag="RVR_1447"
     CDS             703..1890
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1268: mandelate racemase/muconate lactonizing enzyme"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010267932.1"
                     /locus_tag="RVR_RS05135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1447"
                     /product="mandelate racemase/muconate lactonizing enzyme
                     family protein"
                     /protein_id="WP_202232702.1"
                     /transl_table=11
                     /translation="MLTVNTTRPPGPAGRISKVETLQLGTAWRDFGYVRIHTDEGLTGV
                     GEITHPYRVDETCRLAEAMGHRHLLGADPFDVEELWLRMYQGDFLRGGDIGGVVVSGVD
                     QALYDLMGKALGVPVHRLTGGATRDRVRVYANGWYTGEREPAEFAAKAKETVAKGFTAL
                     KFDPFGAGLHELERPELRRSLALVAAVREAVGPEVDLFVEGHARFAMATARRLVHELEP
                     YDIGWFEEPLPWTHIERYAELRQIAAFPISGGEHFHNRYEYKQLFASNAVDIVQPDLSM
                     AGGFTEVRKIAAQADAHGMLVAPHNSNSPLCTTASVHATLGITNLKILETFDGLLEPYV
                     FEAVRGALPIVDGHIGLSTAPGLGVELVDEVFAEHPPTHRFWNMFADGWEKRNRT"
     gene            1887..2735
                     /locus_tag="RVR_RS05140"
                     /old_locus_tag="RVR_1448"
     CDS             1887..2735
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835504.1"
                     /locus_tag="RVR_RS05140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1448"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_202232703.1"
                     /transl_table=11
                     /translation="MIVDVHSHLFRHSHDFDDAFRAESARAHAGEVDLTVRYEDYAASA
                     PEGTRTVVVGGKARRSGLWVDDAAVADYVGRHPDRLIGYLSIDPTQPGWEDELRYGHQE
                     LGLRGIKLMPMYAGFDPADEAYEPLYAYAERHGLPLLVHTGTTFVSQAPLEYAMPRHLD
                     WVAMRHPELRMVLAHLSHPFEGECIAVIRKHRHVYADVSALHYRPFQLWHSLRLVQDYG
                     VWDKLLFGSDYPFTTVDDSVEGLRRIARVPGIPGLDPLDQEAVEALIHRPSLDLLGLEP
                     S"
     gene            2858..3682
                     /locus_tag="RVR_RS05145"
                     /old_locus_tag="RVR_1450"
     CDS             2858..3682
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (4-168). E-value: 2.9e-17. Score:
                     55.1. Matches aSDomain:
                     nrpspksdomains_RVR_RS05145_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547346.1"
                     /locus_tag="RVR_RS05145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1450"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_237405239.1"
                     /sec_met_domain="adh_short (E-value: 3.6e-35, bitscore:
                     120.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGRTALVTGAARGLGRAFAVALAEAGADLVLTDLPGAAGLAETA
                     ARVRESGRGALVVEQDLSDTAALHGFADRVRAQAGPIRVLVNNAGTAALERFNEITPES
                     WYRVMRVNLDAVFFLTQRLAEHMVADGVPGRIVNITSKNALVAEAGLAHYNASKAAVDL
                     LTQTLAVELAPHGITVNSLAPGMVETPIDGEFPFDREAFEAAYRRRIPLGRYARPEECA
                     AALLLLAGDGGAYLTGSRIVVDGGVLADQMPRTAFMPPYRSSLGGGEGGATG"
     aSDomain        2870..3361
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RVR_RS05145_PKS_KR.1"
                     /evalue="2.90E-17"
                     /label="RVR_RS05145_PKS_KR.1"
                     /locus_tag="RVR_RS05145"
                     /protein_end="168"
                     /protein_start="4"
                     /score="55.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TALVTGAARGLGRAFAVALAEAGADLVLTDLPGAAGLAETAARVR
                     ESGRGALVVEQDLSDTAALHGFADRVRAQAGPIRVLVNNAGTAALERFNEITPESWYRV
                     MRVNLDAVFFLTQRLAEHMVADGVPGRIVNITSKNALVAEAGLAHYNASKAAVDLLTQT
                     L"
     CDS_motif       2876..2947
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RVR_RS05145_0001"
                     /evalue="3.10E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="RVR_RS05145"
                     /protein_end="30"
                     /protein_start="6"
                     /score="19.8"
                     /tool="antismash"
                     /translation="LVTGAARGLGRAFAVALAEAGADL"
     gene            3891..4844
                     /locus_tag="RVR_RS05150"
                     /old_locus_tag="RVR_1452"
     CDS             3891..4844
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007830017.1"
                     /locus_tag="RVR_RS05150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1452"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_202232704.1"
                     /transl_table=11
                     /translation="MPYRTATPADEAALHALWAAAFPEADAAAVVALWGRDPGRHGRTL
                     VAEDGGGRLVSALHHLPRPIRSATGAPQRVGCVGSVATRPDARGRGHVRRLLAAAVAAM
                     TADGCAWSLLFTATPRVYEGAGWRSFAAPGWSGRPAGRTPHPGAAAVRPATAGDLPVLR
                     ALRTAYDAGRPLTTVRSADDWAHRVPVWYAPPTRILVATTGGAGSPATGFVVLRRPAPG
                     AFEVVEIALAPGHEEAAAGALLSAAAVRARAAGTATATVRLPADPAVVAALPHLLADPA
                     PSPTHHGMARPLLAPPAEVHATVTAPTAFHWPADAF"
     gene            4941..5462
                     /locus_tag="RVR_RS05155"
                     /old_locus_tag="RVR_1453"
     CDS             4941..5462
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.4"
                     /locus_tag="RVR_RS05155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1453"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_202232705.1"
                     /transl_table=11
                     /translation="MPRSMLIHDGRTTRELGLVYCCSGYLVERGKVLLVHHNRFDKWVP
                     PGGHLEPGESFAETAVREFKEETGLLVEAISSQPAVHPADHHATPEPVPFYVDVEREGF
                     PTPALVQFFYVRRLPGTREQAVEAQLEEVQGAAWFGLEDIDGIETFDQVRSLARFALLN
                     YPVAAERAAS"
     gene            6086..6682
                     /locus_tag="RVR_RS05160"
                     /old_locus_tag="RVR_1455"
     CDS             6086..6682
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018560144.1"
                     /locus_tag="RVR_RS05160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1455"
                     /product="TetR-like C-terminal domain-containing protein"
                     /protein_id="WP_202232706.1"
                     /transl_table=11
                     /translation="MVRAGLTPERLTRAGAELADEVGFAQVTVSALARHFDVKVASLYS
                     HVRSSQDLKVRIALLALEEMADRAGAAVAGRAGKDALAAFAEAYRGYAREHPGRYEAAR
                     LRLDPETAAGSAGVRHAQMTRAILRGYHLAEPDQTHAVRMLGSAFHGYVDLELSGAFSH
                     TPVAAEESWAWLLDSLDLLLRDRAPLDHQTDRQGR"
     gene            6679..7875
                     /locus_tag="RVR_RS05165"
                     /old_locus_tag="RVR_1456"
     CDS             6679..7875
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044367.1"
                     /locus_tag="RVR_RS05165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1456"
                     /product="GDSL-type esterase/lipase family protein"
                     /protein_id="WP_202232707.1"
                     /transl_table=11
                     /translation="MSTEHDWTTTPLTAAMLRGAVEVEHTAHGLLPHRLPAAARRQFPD
                     GQLVMAEAQPSGVRLVFRTRATAVELDTLPTKRVYVGAPPPPDGVYDLLVDGRLAGQAT
                     VPGGRLRTIDMATQAVELTEGPAGTARFAGLPGHDKRVEIWLPHNEGAELVALRTNAPV
                     GPAADGTRKVWLHHGSSISHGSNATHPTGIWPALAAARGDVELVNLGFGGGALLDPFTA
                     RAMRDIPADLISVKLGINIVNADLMRLRAFGSAVHGFLDTVREGHPDTPLLVVSSILCP
                     VQEDTPGPLAPDFGGGVLRFKATGDPAERAAGRLTLNVIRAELARIVERRAADDPHLHY
                     LDGRELYGEADYAELPLPDEVHPSPEAHRRIGANFARLVFGPGGAFHSARTRPAGATA"
     gene            8487..9926
                     /locus_tag="RVR_RS05170"
                     /old_locus_tag="RVR_1457"
     CDS             8487..9926
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557598.1"
                     /locus_tag="RVR_RS05170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1457"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_237404579.1"
                     /transl_table=11
                     /translation="MPEPGHTTGATTDDPAADPASGAQLTSLSTRAARQLATTTKSEPQ
                     MQGISSRWLIRMLPWLDIKGGTYRVNRRLHLRVGRGRVAFEHNGADDIRVVPETLTELP
                     PLHGYSDTGVLAELASRFRPREVRPGEVLCEAGQPITDTYLVVHGRLTRYAEGLYGEEG
                     VVGVLTDGDQVGDEAVGQAEPRWTTSVRADTAGVLLALPWQSLRELTAREASLAAHLAA
                     YAERQKLPANRRGEADIPMQAGHTGEPTLSSGFVDYELRPREYELSLTQTVLKVHSRVS
                     DLYNDPMDQTQQQLRLTIEAIRERQEWELVNNREFGLLHNTDYGQRISTYSGPPTPDDL
                     DDLLAMRRKTRLFIAHPKAIAAFFRQCNKRGLLPGSADVGGHQVPAWRGVPIFPCGKIP
                     VSAQHTSSIIALRTGEDDQGVVGLHATGIPEEYQPGLNVRFMGVNQAAVISYLVTAYYS
                     MAILVPDAVGILENVQLGRVE"
     gene            10001..11029
                     /locus_tag="RVR_RS05175"
                     /old_locus_tag="RVR_1458"
     CDS             10001..11029
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069178.1"
                     /locus_tag="RVR_RS05175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1458"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_202238400.1"
                     /sec_met_domain="T1TS (E-value: 3.2e-53, bitscore: 180.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLPGPPSLPRSVAARRTGAIPGLTYRAVTPPDPEKVAEVDRRLE
                     AWARGLDLFPTAWTGDFAGFQFGRAVVLQHPGAADLDRLTAAGELLLAENLVDDCYCEE
                     EEDRGGSHRGLGGPLIMAQSAIDPYHGTAGSEEDWRQGMQADGPLRSYHWAMKDYAGFA
                     TPSQTTRFVHDIARLHLGYLAEAAWAETGHMPKVWEYLVMRQFNNFRPCLSIVDAVDGY
                     ELPEPLYSRPEVQRITALASNATTLVNDLYSFTKELETDPTHLNLPQVVAANERCGLKT
                     AYLRSVEIHNQIMASFEEEAAALSATSPLVGRYARGLSDWVAGNHEWHATNTHRYHLPN
                     YW"
     gene            11085..11960
                     /locus_tag="RVR_RS05180"
                     /old_locus_tag="RVR_1459"
     CDS             11085..11960
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069177.1"
                     /locus_tag="RVR_RS05180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1459"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_202232709.1"
                     /transl_table=11
                     /translation="MTTTHRGTTTAPVPAQSTYQTRVADYWNAEENPVNLELGKIDDLY
                     HHHYGIGEADRSVLDEPDPALRRERITAELHRLEHAQAELLASRLGPLTPADRVFDAGC
                     GRGGGSVVAHLRYGCSADGVTLSTKQADFANEQARARGIDGKVRYHHRNMLDTGFRTGG
                     YAASWNNESTMYVELDLLFAEHARLLRRGGRYVTITGCYNDTYGRASREVSLINAHYIC
                     DIHPRSAYFRAMAANRLVPVHVEDLTATAIPYWELRRQAEHLVTGVEEPFLTAYRNGSF
                     QYLMIVADRV"
     gene            complement(12075..13220)
                     /locus_tag="RVR_RS05185"
                     /old_locus_tag="RVR_1460"
     CDS             complement(12075..13220)
                     /EC_number="3.1.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121521.1"
                     /locus_tag="RVR_RS05185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1460"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_202232710.1"
                     /transl_table=11
                     /translation="MRRSPLLFALALAAAVGVGAGTALPAAAAAGRHAVAVQAAPAAGA
                     SSLRVMPLGDSITWGVGSSTGDSYRSALAAELTGEGHTLDFVGSGRDGTMSDPDNEGHS
                     GWRIDQIAGIADGVLDRYRPNVVTLEIGTNDLNQNYQVATATDRLHALIDQITTDRPGV
                     TVLVGSLIVSTNPVEEPNRPAFNAAVPGIVQAEQAAGRHVGFVDMSALTAADLSDQLHP
                     NDGGYQKMADAFDAGVRSADAAGWIAPPVPNGGAVRSGIAGKCLDDNGDNPANGTAVQL
                     WSCNSSDAQWWQLRTDGTLRAVGKCLDATGNGTGDGTKVQLWDCNGGANQVWQPYNGGY
                     RNPVSGRCLDDPNSSTTDGTQLQLWDCNGTNAQKWTTLGVI"
     misc_feature    complement(13203..13205)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13305..14789)
                     /locus_tag="RVR_RS05190"
                     /old_locus_tag="RVR_1461"
     CDS             complement(13305..14789)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192341.1"
                     /locus_tag="RVR_RS05190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1461"
                     /product="glycoside hydrolase family 76 protein"
                     /protein_id="WP_202232711.1"
                     /transl_table=11
                     /translation="MRAMRPLRIVVLAAALTTMSATVAQGAAPPADAAASAAAAPSATA
                     ATTICNSYCDARDPALSTQDRQPVSATVNSRSIVLHFDDNDAMAWASIGNGGAGDEVWL
                     DRSMDGGRTWSAGSKLGDTKVPSGSGGWRTLMYNVDDWNNEGVGAVRACGEASGSTAIA
                     CTSWARTTWNAWSRGTAAATALMMSYDRGTKLFGGNGWWTSANALTAIIDDARISGMPS
                     YKYAISETYNANINAQDGNFTNSYLDDTGWWGLAWVDAYDATGDSRYLATARADADHMA
                     DNWNTVCGGGVRWNTGGEYKNAITNELYLYLDAALHNRISGDTTYLGRANTEWSWFQNS
                     GMINGDHMINDGLSDACVNNGQTTWTYNQGVVLGGLTELYKATGNSGLLDTARTLANAS
                     TVKLQTAGVLREPGEGDSCTGDGPSFKGAYVRGLGKLNTQLSDHPYAADLTAWANSAYA
                     HDRNSLDQYGPHWAGGTGSSDYGCQQSVLDLLNAAG"
     misc_feature    14763..14781
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.87"
                     /tool="antismash"
     misc_feature    complement(14774..14784)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            complement(15243..16172)
                     /locus_tag="RVR_RS05195"
                     /old_locus_tag="RVR_1462"
     CDS             complement(15243..16172)
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020140967.1"
                     /locus_tag="RVR_RS05195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1462"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_202232712.1"
                     /sec_met_domain="APH (E-value: 4.9e-34, bitscore: 117.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESESATESGTRAGSGTGITADLVRDLLREQHPDLAGLPLREVA
                     GGWGNQMWRLGDELAVRMQRMDRTPGPQLKERRWLPVLAPRLPLPVPTPVRSGEPSARF
                     PKHWTVMTWVPGEPLDHGVISRGAHAADTLASFLRALHVEAPVEAPVGTDRGAHPRDCA
                     DGFEDFFRAVAPDDLAADVRAVWDDAVAAPAWRGPPVWVHGDLHPANVVVADGTLSGVV
                     DFGDVFAGDPAWDLAAAWVLLPAGTAARFFDAYARADEAAVRRARGLAAMKSLFLMLMG
                     RNGDQGLPGGKPHWGPLGRAALDRVLAG"
     gene            16237..16971
                     /locus_tag="RVR_RS05200"
                     /old_locus_tag="RVR_1463"
     CDS             16237..16971
                     /EC_number="3.4.13.21"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016805 - dipeptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004991562.1"
                     /locus_tag="RVR_RS05200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1463"
                     /product="peptidase E"
                     /protein_id="WP_202232713.1"
                     /transl_table=11
                     /translation="MTAAEPTVLATSGGHRAGGRTRVEFDALVHHAVELSGAHGRRPRI
                     MYVGTAIGDAEHFTARMAEAARVAGFDLTPLHLFPMPNLEDVEGTVLEQDVVWVMGGSV
                     VNLLAVWRAHGVDRVMRRAWRAGVVLSGVSAGSICWFRGGATDSFGRRLRPVTDALGLL
                     PYGNGVHYDSDAGRRPLIHRLVADGTLPTSHCTDDGVGLVYRGETLVEAVTEVPGKGAY
                     VVRREGQDAVEERLEPRRLPSV"
     gene            complement(17302..17940)
                     /locus_tag="RVR_RS05205"
                     /old_locus_tag="RVR_1465"
     CDS             complement(17302..17940)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS05205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_1465"
                     /product="hypothetical protein"
                     /protein_id="WP_202232714.1"
                     /transl_table=11
                     /translation="MSVFRSAGRLMAVLTALLVLPAMLVLPQSASASEAGHSGSAIAVK
                     VHVARDAASGASPRTCYAVSGHFISRYNQNPGGWGCAVTPEYAYLDGTYQEFANGEMDW
                     SPSQGGNMVVSGLRYPGGIYFQFGPSDPFNYDAWLVRISQEGGGTFQPECSSGSNDGQG
                     NYCDRSNGAVHLGTTSTGHWQIITEGCDVSWTGSHTCRQSWTIPVDIWY"
     misc_feature    17935..17946
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 21.4"
                     /tool="antismash"
     gene            complement(18208..18603)
                     /locus_tag="RVR_RS05210"
                     /old_locus_tag="RVR_1467"
     CDS             complement(18208..18603)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018384566.1"
                     /locus_tag="RVR_RS05210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1467"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_202232715.1"
                     /transl_table=11
                     /translation="MLIDTVAWVRIEDGRILCARPRGKGVFYIPGGKREGAETDLQTLV
                     REIREELTVRIDPGTAAHAGTYEAGGPGLPDGALVRMACYTASYEGRLAPSSEIEEVAW
                     FSYADRERVPPVDQLLFDDLNSRGELP"
     gene            complement(18689..19954)
                     /locus_tag="RVR_RS05215"
                     /old_locus_tag="RVR_1468"
     CDS             complement(18689..19954)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010356199.1"
                     /locus_tag="RVR_RS05215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1468"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_237404580.1"
                     /transl_table=11
                     /translation="MTQGGTNLPRVGGYNQAVILDAIRTAGPVSRVELAPLTGLTSQTV
                     SNVVRRLLAAGLITESGYAPSSGGKRRTLLSPRADGAFAVGVQLDPDGAVVVVVDLAGE
                     VLASRRVRLVDPGEPADVVARVAAAARRLTARTRVDPARLLGTGIATPGPIDGTAGDVV
                     LPPNFPGWGRVPLLEMFGAATGMPVAMDNDATAAAIGERWIGGRARAGSFLFLYLGTGI
                     GAGIVLNNTVLHGDSGNAGEFGHMAVEPGDRICHCGGNNCLGPYVSPSAVLSDLLVRHG
                     RGAAERIGLACAEDSVHADWKLLCRAARRGDPAARDVVRAAAARIGQAARGAVALLDVE
                     RVVLGGEALRGIEAIMCEEVASAVNTTSVTRAIRPVAVERSVIGDAVGAVGAASLVLHG
                     TYAPGWRMLTQPSPSPSPTPPA"
     misc_feature    complement(20204..20219)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.85"
                     /tool="antismash"
     misc_feature    complement(20219..20230)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
ORIGIN
        1 gcgcgcgctg cgcgaggagt gcaccgcggc cggcagcgtg ctggtcttcg acgaggtgat
       61 caccggcttc cggcacgccc tcggcggcta ccaggcgatc tccggcgtca ccccggacct
      121 caccaccctc ggcaaggcga tcgccaacgg cgccccgatc ggcgcgctcg gcgggcgcgc
      181 cgacctgatg cagtacttca gcagccgccc gggcggcccg gtcttcttcg ccggcaccta
      241 caacggccac ccgctgccgg tcgccgccgc gctggccacc gtgcgcaagc tgcgcgagca
      301 gccggtgcac gagcacgtct tccggctcgg cgaccgggtg cgcggcgaac tcaccgcgct
      361 ctacgagcgg atgggcgtgc ccgccgtggt gaccggctac ggctcggtct tcgtcagcta
      421 cttcatgccc ggcccggccc cgctcagcta cgacgacctg ctcgccaacg acaccgcgct
      481 gttcgtcggc taccgccgcc acctcgtgga acacggcatc ttcgaactgc cgctcaacct
      541 caagcgcagc cacctgtcct acgcccacac cgacgccgac gtcgaccggc tgctggaggc
      601 caccgaggcg gcggtccggc gcaccctggc cgagggcggc ccgagcgacc tgacccacac
      661 ctcgaccatg ggcggcgccg ccaccacgac gggagcacgc tgatgctgac ggtgaacacc
      721 actcgcccgc ccggcccggc gggccggatc agcaaggtcg agaccctgca actgggcacc
      781 gcctggcgtg acttcggcta cgtccggatc cacaccgacg agggcctgac cggcgtcggc
      841 gagatcaccc acccctaccg ggtggacgag acctgccggc tcgccgaggc gatgggccac
      901 cgccacctgc tgggcgccga cccgttcgac gtcgaggaac tctggctgcg catgtaccag
      961 ggcgacttcc tgcgcggcgg cgacatcggc ggcgtggtcg tctccggcgt ggaccaggcg
     1021 ctgtacgacc tgatgggcaa ggcgctgggc gtgcccgtgc accggctgac cggcggcgcc
     1081 acccgcgacc gggtccgggt ctacgccaac ggctggtaca ccggcgagcg cgagccggcc
     1141 gagttcgccg ccaaggcgaa ggagaccgtc gccaagggct tcaccgcgct gaagttcgac
     1201 ccgttcggcg cgggcctgca cgaactggaa cgacccgagc tgcgccgctc gctggccctg
     1261 gtcgccgccg tgcgcgaggc ggtcggcccc gaggtggacc tcttcgtcga ggggcacgcc
     1321 cggttcgcga tggccaccgc ccgccggctg gtgcacgagc tggagccgta cgacatcggc
     1381 tggttcgagg aaccgctgcc ctggacgcac atcgagcgct acgccgagtt gcggcagatc
     1441 gcggccttcc cgatctccgg cggcgagcac ttccacaacc ggtacgagta caagcagctc
     1501 ttcgcgagca acgcggtgga catcgtgcag cccgacctgt cgatggccgg cggcttcacc
     1561 gaggtgcgga agatcgccgc ccaggccgac gcgcatggca tgctggtagc cccgcacaac
     1621 tccaactcgc cgctgtgtac caccgcttcg gtgcacgcca cgctcgggat caccaacctc
     1681 aagatcctgg agaccttcga cgggctgctc gaaccgtacg tcttcgaggc ggtgcgcggc
     1741 gcgctgccga tcgtcgacgg acacatcggg ctgtccaccg cgcccggact cggcgtcgag
     1801 ctggtggacg aggtcttcgc ggagcacccg cccacgcacc gcttctggaa catgttcgcg
     1861 gacggctggg agaagaggaa ccgcacatga tcgtcgacgt gcactcccat ctcttccggc
     1921 acagccacga cttcgacgac gccttccgcg ccgagtccgc ccgggcgcac gccggcgagg
     1981 tggacctcac cgtgcggtac gaggactacg cggcgagcgc cccggagggc acccggaccg
     2041 tggtggtcgg cggcaaggcg cgccgcagcg ggctgtgggt cgacgacgcg gccgtggccg
     2101 actacgtcgg ccggcacccc gaccggctga tcggctacct ctcgatcgac ccgacccagc
     2161 ccgggtggga ggacgaactg cgctacggtc accaggagtt gggcctgcgc ggcatcaagc
     2221 tgatgccgat gtacgccggc ttcgacccgg cggacgaggc gtacgaaccg ctgtacgcct
     2281 acgccgagcg gcacggcctg cccctgctgg tgcacaccgg caccaccttc gtctcgcagg
     2341 cgccgctgga gtacgccatg ccgcggcacc tggactgggt ggccatgcgc cacccggagc
     2401 tgcggatggt gctcgcccac ctcagtcacc ccttcgaggg cgagtgcatc gcggtgatcc
     2461 gcaagcaccg gcatgtctac gcggacgtca gcgccctgca ctaccggccg ttccagttgt
     2521 ggcacagcct gcgcctggtg caggactacg gggtgtggga caagctgctg ttcggcagcg
     2581 actacccgtt caccacggtg gacgactcgg tggaggggtt gcgccggatc gcccgcgtcc
     2641 ccggcatccc cgggctcgac ccgctcgacc aggaggcggt cgaggcgctg atccaccgcc
     2701 cgtcgctgga cctgctcggg ctggagccgt cgtgaccggt gcgggtgggg cccctgccgc
     2761 gggcggcgcg atcggtgcgg gtggcacggg cggcgcgggc ggtgcgggtg gcacgggcag
     2821 tgcgggcggt gccggtccgg ccggggcgcc cttcgacctg accggccgca ccgcgctggt
     2881 caccggcgcg gcccgcggcc tgggccgggc gttcgcggtg gcgctcgccg aggcgggcgc
     2941 cgacctggtc ctcaccgacc tgcccggcgc ggccggactc gcggagaccg ccgcgcgcgt
     3001 gcgggagtcg ggacgcggcg cgctcgtcgt cgagcaggac ctgtccgaca ccgcggcgct
     3061 gcacggtttc gccgaccggg tgcgcgcgca ggccgggccg atccgcgtcc tggtcaacaa
     3121 cgccggcacc gccgcgctgg agcggttcaa cgagatcacc ccggagagct ggtaccgcgt
     3181 catgcgggtc aacctcgacg cggtgttctt cctgacccag cggctggccg agcacatggt
     3241 ggccgacggt gtacccggcc ggatcgtcaa catcacctcc aagaacgcgc tggtcgccga
     3301 ggccgggctg gcgcactaca acgcgtcgaa ggccgcggtg gacctgctca cgcagaccct
     3361 cgcggtggag ctggcgccgc acggcatcac cgtcaacagc ctggcccccg gcatggtcga
     3421 gaccccgatc gacggcgagt tcccgttcga ccgggaggcg ttcgaggcgg cgtaccgccg
     3481 gcgcatcccg ctcggccgct acgcgcggcc cgaggagtgc gccgccgcgc tgctgctgct
     3541 cgccggcgac gggggcgcct acctgaccgg cagccggatc gtggtggacg gcggggtgct
     3601 ggccgatcag atgccgcgga ccgcgttcat gccgccgtac cgctcgtcac tcggcggcgg
     3661 ggagggcggc gccacgggct gaccggcacg cgcggtacgt acggccgggt acccgcgtgg
     3721 tcgggggccg tacggacggc tcggaccgta gggatcctgc cgaccgccac cgtaggaccg
     3781 ttgatccctg atcactactc acagaccgct gaccgccagc cgttgaccgt tgaccgctgg
     3841 ccactggcca ctggccactg gccgacggtc ggcagggagg agccgccgtc atgccgtacc
     3901 gcaccgcgac cccggcggac gaggcggcgc tgcacgcgct gtgggcggcg gccttcccgg
     3961 aggcggacgc ggccgcggtc gtcgcgctgt ggggccggga cccggggcgg cacggccgca
     4021 cgctcgtcgc cgaggacggt ggcggacggc tggtctcggc cctgcaccac ctgccgcggc
     4081 cgatccgctc ggccaccggc gcaccgcagc gggtcgggtg cgtcggcagc gtggccaccc
     4141 gtcccgacgc gcgcggccgg ggccacgtcc ggcgcctgct cgcggcggcg gtcgccgcga
     4201 tgacggcgga cgggtgcgcc tggtccctgc tgttcacggc caccccgcgg gtctacgagg
     4261 gcgcgggatg gcggtccttc gccgcgcccg gctggtcggg ccggcccgcc ggccggaccc
     4321 cgcaccccgg tgccgcggcc gtacgccccg cgaccgccgg cgacctcccg gtcctgcgcg
     4381 ccctgcgcac cgcctacgac gcgggccgcc ccctgacgac cgtgcgcagc gcggacgact
     4441 gggcgcaccg cgtccccgtc tggtacgcgc cgccgacccg gatcctggtg gcgaccaccg
     4501 gcggtgccgg cagtcccgcg acgggtttcg tcgtcctgcg ccgccccgcg cccggcgcct
     4561 tcgaggtcgt ggagatcgcg ctggccccgg gccacgagga ggccgcggcc ggcgccctgc
     4621 tgtcggctgc ggcggtgcgc gcccgcgccg cgggcaccgc gaccgcgacg gttcggctcc
     4681 ccgccgaccc cgccgtcgtc gccgccctcc cccacctcct cgccgacccg gccccctccc
     4741 ccacccacca cggcatggcc cgccccctcc tcgccccgcc cgccgaggtc cacgccaccg
     4801 tcaccgcccc caccgccttc cactggcccg ccgacgcctt ctgacacccc cgccgggtcg
     4861 ccggcgcacg gcacaccgga agtccggtgc agggtcgggg agttgggggg cgggtgggtg
     4921 ggtggattat cgtgggcggc gtgcctcgct cgatgttgat ccatgacggc cggaccacgc
     4981 gtgaactcgg tctggtgtac tgctgctccg gctatctcgt cgagcgcggc aaggtgttgc
     5041 tggtgcacca caaccggttc gacaagtggg ttccaccagg ggggcacctc gaacccgggg
     5101 agtcgttcgc cgagacggcg gtgcgggagt tcaaggagga gacggggctg ctggtggagg
     5161 cgatctccag tcagcccgcc gtccatccgg ccgaccacca cgccacccct gagcccgtgc
     5221 cgttctacgt ggacgtggag cgcgaggggt ttccgacccc ggcgctggtc cagttcttct
     5281 acgtgcggcg gctgccgggc acccgcgagc aagccgtgga ggcgcagctc gaagaggtcc
     5341 agggcgccgc gtggttcggc ctggaggaca tcgacggcat cgagaccttc gaccaggtcc
     5401 gctccctggc ccggttcgcg ctgctcaact atccggtggc ggccgagcgc gccgcgtcgt
     5461 agacggccgt cggccatccg tcgtcgcgcc gtgaggcgca acccatccac ggtcgcagca
     5521 cacctacagc ggcaggccac cgcgtccgcc gacacccgca tccacggcgt cggtgtgcgg
     5581 tgccgggcga tcacccggcc gaggacgtcc cctgcgtacc gctgacgcgg cagccactgc
     5641 ggggccgcct gccggatggt ctccagcttg tccacggcct cggcctacca ccgcaggcgc
     5701 accagcgcgc cggcctggtc ccagcggtcg cggttgaggt tgttcgaggt cgggcgcatc
     5761 cctcccagga gatcaccgcc gacaggtgca gcacccggtc cggcccggcc cggtccgtga
     5821 tcatggagtg cccggccccc ttgagccgca acgtccaggc gtcgaacgcg cgcgggaacc
     5881 tgcccggaac gacccgtcgc ccaagtgcgg gcgccaccga acccgccagg ccccttgcca
     5941 cgcacccgcc agccgccacc cgccagccgc cagccgccag ccgccagccg ccagccgctg
     6001 ccaccgtcgg cctgcgcggg cctaggcatt tgcctaaatg cattaggtag atgcaggatg
     6061 gatctaggca agaaggagga aggtcatggt tcgagcgggg ctgaccccgg agcggctgac
     6121 ccgggcggga gccgaactcg ccgacgaggt cggcttcgcc caggtgaccg tctcggcgct
     6181 cgcgcggcac ttcgacgtga aggtcgcgag cctctactcg catgtgcgca gttcgcagga
     6241 cctgaaggtg cggatcgcgc tgctggcgtt ggaggagatg gcggaccggg cgggcgcggc
     6301 ggtggcgggg agggccggca aggacgcgct cgcggcgttc gcggaggcgt accggggcta
     6361 cgcgcgggag cacccgggcc ggtacgaggc ggcgcggctg cggttggacc cggagacggc
     6421 ggcgggcagc gcgggcgtgc ggcacgcgca gatgacccgg gcgatcctgc gcgggtacca
     6481 cctggcggag ccggaccaga cgcacgccgt gcggatgctg ggcagcgcat tccacggcta
     6541 cgtggacctg gagctgagcg gggcgttcag ccacaccccg gtcgccgccg aggagtcgtg
     6601 ggcgtggttg ctcgactcgc tcgacctcct cctgcgcgac cgcgcacccc tcgaccacca
     6661 gaccgacagg cagggacgat gagcaccgag cacgactgga ccaccacccc cctgaccgcc
     6721 gccatgctgc gcggcgccgt cgaggtggag cacaccgcgc acggcctgct gccgcaccgg
     6781 ctgcccgccg ccgcgcgccg gcagttcccc gacgggcaac tggtcatggc cgaggcgcag
     6841 ccgtccggcg tacggctggt cttccgcacc cgggcgacgg cggtcgagct ggacaccctc
     6901 cccaccaagc gcgtctacgt cggcgcccca ccgcccccgg acggggtgta cgacctgctg
     6961 gtcgacgggc gcctcgccgg ccaggccacc gtgcccggcg gacggctgcg caccatcgac
     7021 atggccacgc aggcggtgga gttgacggag gggcccgccg gcaccgcccg gttcgcgggt
     7081 ctgcccggcc acgacaagcg cgtcgagatc tggctcccgc acaacgaggg cgccgaactg
     7141 gtcgcgctgc gcacgaacgc gccggtcggg ccggccgccg acgggacccg caaggtgtgg
     7201 ctgcaccacg gcagttcgat cagccacggc tccaacgcga cccacccgac cggcatctgg
     7261 ccggcgctgg cggccgcgcg cggcgacgtc gagctggtca acctggggtt cggcggcggc
     7321 gccctgctcg acccgttcac cgcccgcgcg atgcgcgaca tccccgcgga cctgatcagc
     7381 gtcaagctgg gcatcaacat cgtgaacgcg gacctgatgc ggctgcgggc cttcggctcc
     7441 gcggtgcacg gcttcctcga caccgtccgc gaggggcacc cggacacgcc gctgctggtg
     7501 gtgtcctcga tcctgtgccc ggtgcaggag gacacaccgg ggccgctggc cccggacttc
     7561 ggcggcggcg tcctgcggtt caaggccacc ggcgacccgg cggagcgcgc cgccggacgc
     7621 ctgacgctga acgtgatccg tgccgagctc gcccggatcg tggagcggcg cgcggcggac
     7681 gacccgcacc tgcactacct ggacggccgc gagctgtacg gcgaggcgga ctacgccgaa
     7741 ctgccgctgc ccgacgaggt gcacccctcc cccgaggcgc accgccgcat cggcgccaac
     7801 ttcgcccggc tggtcttcgg cccgggcggt gcgttccact ccgcgaggac acgccccgcc
     7861 ggcgccaccg cgtgaggcac tgacgttgag caggagcggg tgagcacggg cgcgtccgcg
     7921 cgaggcccgt ccccgtccgc acgcccgcgg ccccgtccgc gtctccacgt ccacgcgtcc
     7981 ccgtacgcgg acccgtgccc gtgcacgcgg ccccccgtac gcgccgtccc cccgtaacgc
     8041 acgggccccg tccgccgtac gcacggacca gtcacgcgcg ggcccgtccc gtccccacgg
     8101 ccacgccgcc gacccccacc agcaggcccc cgggagacca ccgcccgggg gcctgcccgc
     8161 gccgtccccc ggcgcgcggc cacgacccgc acgccggggt gacgctcccc cgcgccggcg
     8221 cgcgaggtgc gtcggcggca cgcgcccgcg cgcactcccc tcttccgcct cacccggcag
     8281 gtttgcacca ccgggggcgc gaaggcgccc cctgcccgct ataccgccgc gcgccccccg
     8341 ctgcttggct ggtccctgcg cgcaaccgcc ggcggactcc gccgcgcgaa ccgtcgatgt
     8401 ccgccgactc cgttgtccag caagcccgtt cacctgactc caggtcctct cacgctgcct
     8461 gtccagctcg tcttacggga gaaaacgtgc ccgaaccggg acacaccacc ggcgccacca
     8521 ccgacgaccc cgccgccgat ccggcgagcg gcgcacagct caccagtctc agcacccggg
     8581 cggcgcggca gctcgcgacc accaccaagt ccgaaccgca gatgcagggc atcagctccc
     8641 gctggctgat caggatgctg ccctggctgg acatcaaggg cggcacctac cgcgtcaacc
     8701 ggcgcctgca cctgcgggtc ggccgcggcc gggtggcgtt cgagcacaac ggcgccgacg
     8761 acatccgggt cgtccccgag accctcaccg aactgccgcc gctgcacggc tactccgaca
     8821 ccggcgtgct cgccgagctg gcctcccgct tccggccccg ggaggtacgg ccgggcgagg
     8881 tgctgtgcga ggcgggtcag ccgatcacgg acacctacct ggtcgtccac ggccggctca
     8941 cccgctacgc cgagggcctg tacggcgagg agggcgtcgt cggggtcctc accgacgggg
     9001 accaggtggg cgacgaggcc gtcggccagg ccgaaccgcg ctggaccacc tcggtgcgcg
     9061 ccgacaccgc cggcgtgctg ctggcactgc cctggcagag cctccgggaa ctcaccgccc
     9121 gcgaggcgtc gttggccgcg cacctggcgg cctacgccga gcggcagaag ctgcccgcca
     9181 accgccgcgg cgaggcggac atcccgatgc aggccggcca caccggcgag ccgaccctgt
     9241 ccagcggctt cgtggactac gaactccggc cgcgcgaata cgagttgtcg ctgacccaga
     9301 ccgtgctgaa ggtgcacagc agggtctccg acctctacaa cgacccgatg gaccagaccc
     9361 agcagcaact gcggctgacc atcgaggcga tccgcgagcg ccaggaatgg gaactggtca
     9421 acaaccgcga gttcggactg ctgcacaaca ccgactacgg ccagcggatc agcacctact
     9481 cgggcccgcc gacgcccgac gacctggacg acctgctcgc gatgcgccgc aagacccggc
     9541 tgttcatcgc ccaccccaag gccatcgccg ccttcttccg gcagtgcaac aagcgcggcc
     9601 tgctgcccgg ctccgccgac gtcggcggcc accaggtgcc ggcctggcgc ggcgtgccga
     9661 tcttcccgtg cggcaagatc ccggtcagcg cccagcacac cagcagcatc atcgcgctgc
     9721 gcaccggcga ggacgaccag ggcgtcgtcg gcctgcacgc cacgggcatc cccgaggagt
     9781 accagccggg cctgaacgtc cgcttcatgg gcgtcaacca ggccgcggtc atcagctacc
     9841 tcgtcacggc ctactactcg atggcgatcc tggtgccgga cgccgtcggc atcctggaga
     9901 acgtccagct cggccgggtc gagtgaccgc cgccgaggac cgggtggagc acccggcgcg
     9961 cacgtccccc ggcacccgcc ccccggcccg cccggcccgc ctgccgctgc ccggcccgcc
    10021 gagcctcccg cggtcggtgg ccgcccgccg caccggcgcg atcccggggc tgacgtaccg
    10081 ggctgtcacg cccccagacc cggagaaggt cgccgaggtc gaccgccggc tggaggcgtg
    10141 ggcacgcggc ctcgacctgt tccccaccgc gtggaccggg gacttcgccg gcttccagtt
    10201 cggccgggcc gtggtgctcc agcaccccgg cgcggcggac ctggaccggc tcaccgccgc
    10261 cggcgaactc ctgctggccg agaacctcgt cgacgactgc tactgcgagg aggaagagga
    10321 ccgcggcggc tcgcaccgcg gcctcggcgg cccgctgatc atggcccagt cggcgatcga
    10381 cccctaccac ggcacagcgg ggtcggagga ggactggcgg cagggcatgc aggccgacgg
    10441 gccgctgcgg tcctaccact gggcgatgaa ggactacgcc gggttcgcca cacccagcca
    10501 gaccacccgc ttcgtccacg acatcgcccg cctgcacctg ggctacctcg ccgaagccgc
    10561 ctgggccgag accggccaca tgcccaaggt gtgggagtac ctggtcatgc ggcagttcaa
    10621 caacttccgc ccctgcctgt cgatcgtgga cgcggtggac ggctacgaac tgcccgaacc
    10681 gctctactcc cgtccggagg tccagcggat caccgcgctc gcctccaacg cgacgacgct
    10741 cgtcaacgac ctctactcct tcaccaagga gttggagacc gatccgaccc acctcaacct
    10801 gccgcaggtg gtggccgcca acgagcgctg cggcctgaag accgcgtacc tgcgcagtgt
    10861 cgagatccac aaccagatca tggcgtcctt cgaggaggag gccgccgcgc tgtcggcgac
    10921 ctcgcccctc gtcggccgtt acgcgcgcgg gctgtcggac tgggtggccg gcaaccacga
    10981 gtggcacgcg accaacaccc accgctacca cctgccgaac tactggtagg cgcacatcgc
    11041 tccacccgca ccaccaccag caccctgtac agaaggagtc agtgttgacc acgacccacc
    11101 gcggcaccac caccgcaccg gtgccggccc agtccacgta ccagacccgc gtcgcggact
    11161 actggaacgc tgaggagaac ccggtcaacc tcgaactcgg caagatcgac gacctctacc
    11221 accaccacta cggcatcggc gaggccgacc ggtccgtgct cgacgagccg gacccggccc
    11281 tgcggcgcga gcggatcacc gccgaactgc accggctgga gcacgcgcag gccgagttgc
    11341 tcgcctcccg cctcggaccg ctcacccccg ccgaccgcgt cttcgacgcc gggtgcggac
    11401 gcggcggcgg cagcgtggtg gcgcacctgc gctacggctg ctccgccgac ggcgtgacgc
    11461 tctccaccaa gcaggcggac ttcgccaacg agcaggcccg ggcgcgcggc atcgacggca
    11521 aggtccgcta ccaccaccgc aacatgctcg acaccggctt ccgcaccggc gggtacgccg
    11581 cctcctggaa caacgagtcc acgatgtacg tggagttgga cctgctcttc gccgagcacg
    11641 cccggctgct gcgccgcggc ggccgctacg tcacgatcac cggctgctac aacgacacct
    11701 acggccgggc ctcccgcgag gtgtccctga tcaacgccca ctacatctgc gacatccacc
    11761 cgcgctcggc gtacttccgg gcgatggcgg ccaaccggct ggtcccggtg cacgtcgagg
    11821 acctcaccgc gaccgcgatc ccgtactggg agctgcgccg gcaggcggag catctcgtca
    11881 cgggggtcga agaaccgttt ctgacggcgt accggaacgg cagcttccag tacctgatga
    11941 tcgtggccga ccgggtctga cgcgcccggc ctgcgcgaac gccgagcggc gcgggccggc
    12001 cacgggaggg tgccccgtgg ccggcccgcg ccgccgtcgt gccgtgggcg ggcgcgccaa
    12061 gagatgagtg gacgtcagat gaccccgaga gtcgtccact tctgggcgtt cgtgccgttg
    12121 cagtcccaca gttggagctg ggtgccgtcc gtcgtcgagg agttggggtc gtcgagacag
    12181 cggccggaca ccgggttgcg gtagccgccg ttgtacggct gccacacctg gttggcgccg
    12241 ccgttgcagt cccagagctg caccttggtg ccgtcgccgg tgccgttgcc ggtcgcgtcc
    12301 aggcacttgc cgacggcccg cagcgtgccg tcggtccgca actgccacca ctgggcgtca
    12361 ctgctgttgc aggaccacaa ctgcacggca gtgccgttgg cgggattgtc gccgttgtcg
    12421 tcgaggcact tgccggcgat gcccgaccgc accgcaccgc cgttgggcac cggcggtgcg
    12481 atccagccgg ccgcgtcggc cgaccggacg ccggcgtcga aggcgtcggc catcttctgg
    12541 tagccgccgt cgttggggtg caactggtcg gacaggtcgg ctgccgtcag ggcgctcatg
    12601 tcgacgaacc ccacgtgccg gcccgcggcc tgctcggcct gcacgatgcc gggcacggcg
    12661 gcgttgaacg ccggccggtt gggctcctcc accgggttgg tcgacacgat cagcgagccg
    12721 accagcaccg tcacgcccgg ccggtccgtg gtgatctggt cgatcagcgc gtgcagccgg
    12781 tcggtggcgg tggcgacctg gtagttctgg ttgaggtcgt tggtgccgat ctccagggtg
    12841 acgacgttgg gccggtagcg gtcgagcacg ccgtcggcga tgccggcgat ctggtcgatc
    12901 cgccagccgg agtggccctc gttgtccggg tcggacatcg tgccgtcccg gccgctgccg
    12961 acgaagtcca acgtgtggcc ctcgccggtc agctcggcgg ccagcgcgga ccggtagctg
    13021 tcgccggtgc tgctgccgac gccccaggtg atcgagtcgc ccagcggcat cacccgcagg
    13081 ctcgacgcac ccgcggccgg ggcggcctgt acggcgacgg cgtggcggcc ggcggcagcg
    13141 gccgccggca gcgcggtgcc cgcgccgacg cccacggcgg cggccaacgc cagggcgaac
    13201 agtaaggggg atcgtctcat cgtcgtgcca cgctccttct cgggttcacg cgtctcacgg
    13261 gaagtggggg gaggaagggg tggtgcgagg tacgaacggc cgtgtcaccc ggccgcgttg
    13321 agcaggtcga gcacgctctg ctggcagccg tagtcactgc tgccggtgcc gccggcccag
    13381 tgcgggccgt actggtcgag ggagttgcgg tcgtgggcgt acgccgagtt cgcccacgcg
    13441 gtcaggtccg cggcgtacgg gtggtcggac aactgggtgt tgagcttgcc cagcccgcgc
    13501 acgtaggcgc ccttgaagct cgggccgtca ccggtgcagc tgtcgccctc gcccggctca
    13561 cgcagcacgc cggccgtctg gagcttgacc gtcgaggcgt tggcgagggt gcgcgcggtg
    13621 tccagcaggc cggagttgcc ggtcgccttg tacagctcgg tcagcccgcc gagcaccacg
    13681 ccctggttgt acgtccaggt ggtctgcccg ttgttgacgc aggcgtcgga gagcccgtcg
    13741 ttgatcatgt ggtcgccgtt gatcatgccg ctgttctgga accacgacca ctcggtgttc
    13801 gcccggccga ggtaggtggt gtccccgctg atccggttgt gcagcgcggc gtcgaggtac
    13861 aggtacagct cgttggtgat ggcgttcttg tactcgccgc cggtgttcca ccgcaccccg
    13921 ccgccgcaga cggtgttcca gttgtcggcc atgtggtcgg cgtcggcccg cgcggtggcc
    13981 aggtagcggc tgtccccggt cgcgtcgtac gcgtccaccc acgccaggcc ccaccaaccg
    14041 gtgtcgtcca ggtagctgtt ggtgaagttg ccgtcctgcg cgttgatgtt cgcgttgtag
    14101 gtctcgctga tcgcgtactt gtagctcggc atgccgctga tccgcgcgtc gtcgatgatc
    14161 gcggtcagcg cgttggcact ggtccaccag ccgttgccgc cgaacagctt ggtgccgcgg
    14221 tcgtaggaca tcatcagcgc ggtcgccgcg gcggtgcccc gggaccaggc gttccaggtg
    14281 gtgcgcgccc acgaggtgca cgcgatggcg gtcgacccgg acgcctctcc gcaggcgcgc
    14341 accgcgccga cgccctcgtt gttccagtcg tcgacgttgt acatcagggt gcgccaaccg
    14401 ccggagccgg acggcacctt ggtgtcgccg agcttgctgc cggcgctcca ggtgcggccg
    14461 ccgtccatcg accggtccag ccacacctcg tcgcccgcgc cgccgttgcc gatcgacgcc
    14521 cacgccatcg cgtcgttgtc gtcgaagtgc agcacgattg aacgggagtt gaccgtggcg
    14581 ctcaccggct gccggtcctg cgtgctcagc gcggggtccc gggcgtcgca gtaggagttg
    14641 cagatcgtgg tggccgcggt cgcggaaggc gccgcggcgg cggacgcggc cgcgtcggcc
    14701 ggcggcgccg caccttgggc gacggtggct gacatcgttg tcagggccgc cgcgaggacg
    14761 acgatgcgca ggggtctcat tgcacgcatg gggggctcct gagccgtggt caggcgtgcg
    14821 ggagcacgcc gcttgggggg aagggctctg ctcggaagct agccagcggg tgacggcacg
    14881 tcaataaccc gggcggatgg tcggatcact gcgggaggtc gagcgcgggt ggtgcggggc
    14941 ggccacggcc gggcccgggt cgggacgcgg gtccgtcccg gatcgggacc cggatcgggc
    15001 ccgggtcggg acccgggccg gggccgtacg gtccgctgca tcgcactccg caccggtgcc
    15061 acacgcgccc ccacgtgcgc tcccgtcgca ggaacctcgt cctgcctcct cttgcccatc
    15121 agtggtcgga tgtctgggcg gccgcggcca ggcccgggga agcgcgcgtc acgcgcccgt
    15181 cgttccgtca acccgccaac ccgccaaccc gccaacccgc caacccgcca acccgccaac
    15241 cgtcaacccg ccaggacccg atcgagcgcc gcccggccca ggggccccca gtggggcttg
    15301 ccgccgggaa ggccctggtc gccgttgcgg cccatgagca tcaggaacag gctcttcatc
    15361 gcggccagcc cgcgggcgcg ccgtaccgcc gcctcgtccg ctcgggcgta ggcgtcgaag
    15421 aagcgggcgg cggtgcccgc gggcagcagc acccatgcgg cggcgaggtc ccacgccggg
    15481 tcgcccgcga agacgtcacc gaagtcgacg acgcccgaga gcgttccgtc cgcgacgacg
    15541 acgttcgcgg ggtggaggtc gccgtgcacc cacaccggcg ggccccgcca cgcgggcgcc
    15601 gcgacggcgt cgtcccagac ggcccggacg tccgcggcga ggtcgtccgg ggcgacggcc
    15661 cggaagaagt cctcgaagcc gtccgcgcag tcccgggggt gggcaccgcg gtccgtgccg
    15721 accggcgcct ccacgggcgc ctccacgtgg agcgcccgga ggaagctggc cagggtgtcg
    15781 gccgcgtggg cgccgcggct gatcacgccg tggtccagcg gctcgcccgg gacccaggtc
    15841 atcacggtcc agtgcttggg gaagcgtgcg gacggctcgc cggagcggac cggagtcggc
    15901 accgggagcg gcaggcgcgg ggcgagtacg ggcagccagc gccgctcctt gagctggggc
    15961 ccgggggtgc ggtccatgcg ctgcatgcgc acggccaact cgtcgccgag acgccacatc
    16021 tggttgcccc agccgcccgc cacctcgcgg agcggcagcc ccgcgaggtc cggatgctgc
    16081 tcccgcagca ggtcgcggac aaggtccgcg gtgatcccgg tcccgctccc ggcccgggtc
    16141 ccgctctcgg tcgcgctctc gctctcggtc atggccagcc acactagcga ggcggcggac
    16201 cgggcggctc ccggcgccct cggtacgatc ggcggcatga cagcagcgga accgaccgtt
    16261 ctcgccacct ccggggggca ccgcgccgga gggcgcaccc gggtggagtt cgacgccctg
    16321 gtgcaccacg cggtggagct gtccggggcg cacggaagac gcccccggat catgtacgtg
    16381 ggcaccgcca tcggcgacgc cgagcacttc acggcgcgga tggccgaggc cgcccgggtg
    16441 gcgggcttcg acctgacgcc cctgcacctg ttccccatgc cgaacctgga ggacgtcgag
    16501 ggcaccgtcc tggagcagga cgtggtgtgg gtcatgggcg gttcggtggt caacctgctc
    16561 gcggtgtggc gggcgcacgg cgtggatcgc gtgatgcgcc gcgcgtggcg ggccggggtg
    16621 gtgctcagcg gggtcagcgc cggctcgatc tgctggttcc ggggcggcgc gacggactcg
    16681 ttcgggcggc ggctgcgccc ggtcacggac gcgctggggc tgctgcccta cggcaacggc
    16741 gtgcactacg actcggatgc gggccggcgg ccgctcatcc accggctcgt ggcggacggc
    16801 accctcccga cgtcccactg cacggacgac ggcgtcggcc tggtctaccg cggggagact
    16861 ctggtggagg cggtcaccga agtcccgggc aagggcgcgt acgtggtccg gcgcgagggc
    16921 caggacgcgg tggaggagcg cctcgaaccg cgcaggctgc cgtccgtgtg agcgccccgc
    16981 cggcaacctc cgcgcctgcg cgggcgaccc ccgcaggcgc ggacgggggc gcgggaggcg
    17041 gggccgcgag cgccggcgcc ggctcaagcg gtggaccgcc tcccgcacct ccgacatcgc
    17101 ggacgccgac cgcgcggtgg ggacgtgggg atcgggtgcc ggccgtctcc ttcggcgtgt
    17161 gccggctgaa ttcgatggcg gcgttggcgt cgtggtcgct gtcgtcgccg ttcccggcga
    17221 tgaccacgag ccggtcgtag cggtggaggg cttacgggcc gccggtgtcg ggcgggctgc
    17281 tcacgggttc caggcggccc gtcagtacca gatgtccacc gggatggtcc agctctggcg
    17341 gcaggtgtgg ctcccggtcc aactgacgtc gcagccctcg gtgatgatct gccagtgccc
    17401 ggtgctcgtg gttcccaggt gaaccgcccc gttcgagcgg tcacagtagt tgccctgccc
    17461 gtcgttgctc ccgctgctgc actcgggctg gaaggtgccg cctccctcct ggctgatcct
    17521 caccagccag gcgtcgtagt tgaacggatc cgacggcccg aactggaagt agatgccgcc
    17581 ggggtacctc agaccggaga cgaccatgtt cccgccctgg ctgggcgacc agtccatctc
    17641 gccgttggcg aattcctggt aggtgccgtc gaggtaggcg tactcagggg tgacggcgca
    17701 gccccagccc cctgggttct ggttgtagcg gctgatgaag tggcccgaca cggcgtagca
    17761 ggtgcgcggg gacgccccgg atgccgcatc gcgcgccacg tggaccttga cggcgatcgc
    17821 cgacccgctg tgtccggcct ccgaggcgga cgcggactgc ggcaggacca gcatggcggg
    17881 cagcacgagc agcgcggtga gtacggccat gaggcggccc gcggaccgga agacggacat
    17941 gaacgcgaca cgggaccggg gcggtccggg cggctcggac aggactggcg agcggaacat
    18001 ccgctacccc ctctgagagc tggtggtgac gcggcgacat cgccgcgtca ccacccactc
    18061 tgaggccgaa cgggcacgct gcctggtata cggggaaaaa tacgcatccg gttttcggcc
    18121 ttgttgggag atcgggaaca ggcttctcgg cctgttctcc ggcctccgct tcgggacggc
    18181 cacgcggaag ggtctccggc gcccggatca gggcagctca ccgcgggagt tgaggtcgtc
    18241 gaagagcaac tggtcgaccg gcggtacgcg ttcgcggtcc gcgtacgaga accacgccac
    18301 ctcctcgatc tcgctgctcg gcgccaaccg gccctcgtag gaggcggtgt agcaggccat
    18361 ccgcaccagg gcgccgtcgg gcagaccggg gcccccggcc tcgtaggtcc ccgcgtgggc
    18421 cgcggtcccc gggtcgatcc ggaccgtcag ctcctcccgg atctcccgca ccagggtctg
    18481 gaggtcggtc tcggcgccct cgcgcttgcc cccggggatg tagaagacgc ccttcccgcg
    18541 cggccgtgcg cacaggatcc ggccgtcctc gatccgcacc caggcgaccg tgtcgatcag
    18601 caccgccgtt cccgcccctc cctcgtccgc acctgaccgc cccgacccta ccgagagatg
    18661 ccgccgcacc cggggggccc ggccccgctc aggccggcgg ggtcggggac ggggacgggg
    18721 acggctgtgt cagcatccgc cagcccggtg cgtacgtgcc gtgcagcacc agggacgccg
    18781 cacccaccgc gcccaccgcg tcgccgatca cgctgcgctc gacggcgacg ggccgtatcg
    18841 cccgggtcac cgaggtcgtg ttgacggcgg acgcgacctc ctcgcacatg atcgcctcga
    18901 tgccgcgcag tgcctccccg cccagcacca cccgctcgac gtcgaggagg gcgacggcgc
    18961 cgcgcgcggc ctggccgata cgggccgcgg cggcgcggac gacgtcgcgg gccgccgggt
    19021 cgccgcggcg ggcggcccgg cacagcagct tccagtcggc gtgcacggag tcctcggcgc
    19081 aggccaggcc gatccgctcg gcggcaccgc ggccgtgccg gaccagcagg tcggacagca
    19141 ccgcggaggg gctgacgtac gggccgaggc agttgttgcc gccgcagtgg cagatccggt
    19201 ccccgggctc gacggccatg tgtccgaact cgcccgcgtt gcccgaatcg ccgtgcagca
    19261 ccgtgttgtt gagcacgatg ccggcaccga tgccggtgcc gaggtagagg aagaggaagc
    19321 tgccggcccg ggcccgcccg ccgatccagc gctcgccgat ggcggcggcc gtcgcgtcgt
    19381 tgtccatggc gaccggcatc ccggtggccg ctccgaacat ctccagcagc ggcacccggc
    19441 cccacccggg gaagttcggc gggagcacca cgtcgccggc ggtgccgtcg atcgggccgg
    19501 gcgtggcgat gccggtgccc agcagccggg ccgggtccac ccgggtcctg gcggtgaggc
    19561 gccgtgccgc ggcggcgacc cgggccacca cgtctgccgg ctcgccggga tcgaccagcc
    19621 tgacccggcg cgaggccagc acctccccgg ccaggtccac cacgacgacc accgcgccgt
    19681 ccggatcgag ttgcaccccg accgcgaagg cgccgtcggc gcggggcgac agcagggtcc
    19741 ggcgcttgcc gccgctggaa ggggcgtacc ccgactccgt gatcaggccg gccgccagca
    19801 gccggcgcac cacgttggag acggtctggc tggtcagtcc ggtcagcggt gccagttcca
    19861 cccggctgac cggccccgcc gtccggatcg cgtccaggat cacggcctgg ttgtagcccc
    19921 ccacccgggg cagattggtc ccgccctgcg tcaccgcgtc acgtcctctc ctcgccgtgt
    19981 cacgccttgc gccccgcgtc cgcgccggag tccgcacgcc ccgacgcggg gcgcgcacac
    20041 gacctcgcgc ggcattccgc ttgacccccc gcggcgccgc cgggccggtg cgccgcgctc
    20101 ccccgcgggc ccgtgcacgc gccgcccgcg tacgccccga cccgcccggc aagccctccg
    20161 ccgcacgccc cgcgtgcgct tccgcacccc ccgacggcgg gaagtttaca tgtcagaagc
    20221 gttgacttac tccatccatt ggatttagct tcgccgacaa ccagggcgcc gcccgccctg
    20281 tcggccatgg ggtttccggc tgttggcgcc ctgcggcaca cccgcgtccc gcaccgtccc
    20341 gcacccgtca acgcagggtc gcgggccgcg tccgggcact ccaccggagg ttgaacgtgc
    20401 gcacgagact caccgtcgcc accggcatcg ccgtcgtcac cgcagtgctg gccgcgaccg
    20461 cgtcgggctg cggttccggt tccggcggtt cgggcaagac gatcaaggtc gtgtaccaga
    20521 agcagctcaa cagcagcaac acggtgcagc cggacttcct ggccggccag gtgaaggtgt
    20581 tcgagaaggc gaaccccggc accacggtca aactcgtgcc cgtcaccgcg agcgagaacg
    20641 actactacac caagatccag ctcatgatgc gctcccccgt gaccgcgccc gacctggtct
    20701 acgaggacac cgccaccatc aactccgatg tcgccagcgg ttatctcaag cccctggacg
    20761 gctacctgtc gacctggaag gactggggcc agtacgcggc cgcgtccaag gcggcgatga
    20821 agtacgccga ggacggcaag acctacggcg tcccggacaa caccgacacc cgcggcatct
    20881 ggtacaacaa gacgctcttc gagaaggccg gcatagcggt gccgtggcag ccgaagacgt
    20941 gggccgacgt gctcaccgcc gcccgcgcgg tcaaggcgaa ggtgcccggt gtcaccccga
    21001 tgaacctcta caccggcacc gccggcggc
//
