LOCUS       NZ_AP018365            23979 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  Streptomyces sp. SN-593 chromosome.
ACCESSION   NZ_AP018365
VERSION     NZ_AP018365.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. SN-593
  ORGANISM  Streptomyces sp. SN-593
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Panthee,S., Kito,N., Hayashi,T., Shimizu,T., Ishikawa,J.,
            Hamamoto,H., Osada,H. and Takahashi,S.
  TITLE     beta-carboline chemical signals induce reveromycin production
            through a LuxR family regulator in Streptomyces sp. SN-593
  JOURNAL   Sci Rep 10 (1), 10230 (2020)
   PUBMED   32576869
  REMARK    DOI:10.1038/s41598-020-66974-y Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Takahashi,S., Toyoda,A., Sekiyama,Y., Takagi,H., Nogawa,T.,
            Uramoto,M., Suzuki,R., Koshino,H., Kumano,T., Panthee,S., Dairi,T.,
            Ishikawa,J., Ikeda,H., Sakaki,Y. and Osada,H.
  TITLE     Reveromycin A biosynthesis uses RevG and RevJ for stereospecific
            spiroacetal formation
  JOURNAL   Nat Chem Biol 7 (7), 461-468 (2011)
   PUBMED   21642985
  REMARK    Publication Status: Online-Only
REFERENCE   3
  AUTHORS   Panthee,S., Takahashi,S., Takagi,H., Nogawa,T., Oowada,E.,
            Uramoto,M. and Osada,H.
  TITLE     Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds
            from Streptomyces reveromyceticus SN-593
  JOURNAL   J. Antibiot. 64, 509-513 (2011)
REFERENCE   4
  AUTHORS   Takahashi,S., Takagi,H., Toyoda,A., Uramoto,M., Nogawa,T., Ueki,M.,
            Sakaki,Y. and Osada,H.
  TITLE     Biochemical characterization of a novel indole prenyltransferase
            from Streptomyces sp. SN-593
  JOURNAL   J Bacteriol 192 (11), 2839-2851 (2010)
   PUBMED   20348259
REFERENCE   5  (bases 1 to 8833490)
  AUTHORS   Takahashi,S., Ueki,M., Toyoda,A., Ishikawa,J., Sakaki,Y. and
            Osada,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2017) Contact:Shunji Takahashi Chemical Biology
            Research Group, RIKEN Center for Sustainable Resource Science
            (CSRS); Hirosawa 2-1, Wako, Saitama 351-0198, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Phrap v. 0.990329
            Genome Coverage                   :: 16x
            Sequencing Technology             :: ABI 3730
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016756395.1-RS_2024_05_21
            Annotation Date                   :: 05/21/2024 03:58:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,420
            CDSs (total)                      :: 7,334
            Genes (coding)                    :: 7,181
            CDSs (with protein)               :: 7,181
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 153
            CDSs (without protein)            :: 153
            Pseudo Genes (ambiguous residues) :: 0 of 153
            Pseudo Genes (frameshifted)       :: 35 of 153
            Pseudo Genes (incomplete)         :: 136 of 153
            Pseudo Genes (internal stop)      :: 8 of 153
            Pseudo Genes (multiple problems)  :: 25 of 153
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:29:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1036780
            Orig. end                         :: 1060759
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP018365.1.
            This work was done in collaboration with Shunji Takahashi, Masashi
            Ueki, Atsushi Toyoda, Yoshiyuki Sakaki and Hiroyuki Osada (RIKEN)
            and Jun Ishikawa (National Institute of Infectious Diseases).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23979
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="6"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23979
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23979
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13979](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13979)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(37..1245)
                     /locus_tag="RVR_RS04395"
                     /old_locus_tag="RVR_1235"
     CDS             complement(37..1245)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983239.1"
                     /locus_tag="RVR_RS04395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1235"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_202232580.1"
                     /transl_table=11
                     /translation="MAREQIGLVDILAAAEDAAPVGSVDVVARNLRERFGARYVSFLFV
                     DVVGHKLVRVSEAPDTQEGRRAEQIPLAGSVYEEVLRSQEVVEAEDSGGGRRVLAPVTN
                     RGDTLGVLELTLPHPSPEAVAHVAEAAHALAYIVVTDGRFTDIYHWVQRTTTMSLAAEI
                     QRQLLPSAPSCEAAEFALSAALVPADSIAGDTYDYALDRNTLHLSVTDAMGHDTDASLM
                     ATLLVNASRGARRAGADLAEQARQVHQAMLDHGRRTFATGQLMRIALDGTGAHLVNAGH
                     PWPLRLRDGVVDEIHLDADLPFGVNPAHPRDPYRVQDIDLRPGDRLVLYTDGMQERRAK
                     SVDLRGLVRDTATDHPREAVRTLTAAVIDACDGHMEDDATVICLDWHGPDSGTRHAEAG
                     ADA"
     misc_feature    complement(1262..1277)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.82"
                     /tool="antismash"
     misc_feature    1446..1462
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.28"
                     /tool="antismash"
     misc_feature    1454..1471
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.66"
                     /tool="antismash"
     misc_feature    complement(1456..1473)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.23"
                     /tool="antismash"
     gene            1751..3343
                     /locus_tag="RVR_RS04400"
                     /old_locus_tag="RVR_1236"
     CDS             1751..3343
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012958.4"
                     /locus_tag="RVR_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1236"
                     /product="Ig-like domain repeat protein"
                     /protein_id="WP_237405230.1"
                     /transl_table=11
                     /translation="MSRRVTLSVSAATVAAAVLVPVSAGAQTPNSPSASPKLGVTVTHT
                     GKGPTGYQATFRIKAPTATSMQIKGEWGFASFESVEADSSNAHPVAPSDWKPGDFPLES
                     PNSPGGYWPVASMTEDTKTGVWSYTTPLPSGVFTYSYYANCTAAAPALKGCTGTSDPAN
                     PPWNTTTGSTEANSQVYVPSDPKSGTADASWEADAPAGQRGKLVDVAYPTPNTATGTHP
                     LAVYTPAGYDPKRKTPYPVLVLTHGGGGNEMDWSTQGRMQQIVDNLTRTGKMQPTVIVM
                     PDGGGLTSGASFTSEVADQILPYVEKNYHVGTSANDRSFAGLSAYGTQANNFLFTDTSE
                     FGYYGVWSPAAGAPGVVGNGSGNPVLDADYTNPALKQVLGIHLGIGAEDLGGNLPALTA
                     VTERVGMLNAGVPFTFYTTGGGHTWDFWRQALRDFLTKVDFRATTTTVSTTTAKNTAKA
                     TASVSAATDEPVAPTGTVQFKVDGTDLGKPVKLAGGKATVSATASQLSGHTITAVYSGA
                     TTYNPSTSAAVTG"
     gene            complement(3500..4447)
                     /locus_tag="RVR_RS04405"
                     /old_locus_tag="RVR_1238"
     CDS             complement(3500..4447)
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1260: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018549572.1"
                     /locus_tag="RVR_RS04405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1238"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_237404566.1"
                     /transl_table=11
                     /translation="MRVEANGYPEPANPVRRTASGAPEGPRPPGMTDPPVGTEPVGGTD
                     PVGGTEPPVGTDPPGAGAVSTAVSPILCIDRDIARDHELLQLHAHPEPMLTWSSTATLM
                     GTVARRDWLIPPGYGFWVPGGVEHAGAVLRAGEMLTITFDADRWPLDWTGPTCFAVGPL
                     LREIITHLHRVAPDHHSRAAAEALMFELLTPLPAHHIQVTMPADPRARAVAEQLVAHPS
                     DPRELTAWADHVHAGVRTLSRLFRAETGLTFATWRAHVRIRAAVPMLADGTSVNATARA
                     VGYRKPSAFIAAFRRVTGQTPGTYLPLAAGDADA"
     gene            4599..6053
                     /locus_tag="RVR_RS04410"
                     /old_locus_tag="RVR_1239"
     CDS             4599..6053
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018549573.1"
                     /locus_tag="RVR_RS04410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1239"
                     /product="MDR family MFS transporter"
                     /protein_id="WP_202232582.1"
                     /transl_table=11
                     /translation="MTTPAEPFSPALRRSVGVVMIGASLSFLDSTVVNVALHTLSVDLH
                     AGLGTVQWVVTAYLLALAAVIPATGWAGRRFGAARVYVAALAVFTVGSVLCACAPTAGT
                     LIACRALQGVGGGAIMPVGTMIWTAQSSKAQMGKVMSLIAIPIILAPTLGPAVGGLLIQ
                     GIDWRAVFWLNVPFGVAGVVLAVRLLPREEPQVQGGGAGRLDVTGLVLASAGIVGVTYG
                     LAELGAAAGPDTAAAVALPVGLAALAGFAAHALRAQRPLLDLRLYGGRAFTAASVATFA
                     LGAANFGGMILMPLYLQTVRGDGVVLAGLLLAPTGLGALLSAPFTDRYGAGITAFTGAA
                     VLAVSTLPFVFLTATTPYALICLVMVVRGVGFGLSVIPAMTAAYRALPPDKIPDATPQL
                     NVLQRVGGAIGTAVLTVILNGRLHGHPTPAGRADGFGTTFVWVLAITVAAAVPTLVLAR
                     TERRARRRADAPRPEPGPEEVAEATR"
     gene            complement(6059..7813)
                     /locus_tag="RVR_RS04415"
                     /old_locus_tag="RVR_1242"
     CDS             complement(6059..7813)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="RVR_RS04415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1242"
                     /product="ATP-binding protein"
                     /protein_id="WP_237404567.1"
                     /transl_table=11
                     /translation="MQEPRRGRPLSPLRNDLGPEMTAWANRLREFYTSLGMTLGELERL
                     VGIDATTLSRYLNGRRLPEIAFLGKLDDAVFSRTQTRMHKDVRESVRELYLAACLVHEP
                     QRHEVYMLRDALARAVQRAELAEETVWELQAELHAEQRRRELVENSLRQLEARTGPADD
                     VDTLRRERARALAERDMLTALMEQHSAELVSAMREQYAIAQAREQLATELHGAERVLDE
                     HLESRWGSPDGPDPGRSQEPRPPKAGRWRRRRAGTRRRQRTDLETLRARAEHAARELPR
                     VVGRFSAGDVLDADLSSLLPLPASTYSDDDIARVAAAMDLVLHDAVRLAGEQALLRGNV
                     NAMFTNLSRRSQGLLQRQISLISELEEQEADAAHLASLFKLDHLATRMMRNGENLLVLA
                     GEEPGRRWTSPVPLVDVLRAAASEVEQYERIELTSVPAVEVAGRVVTDLVHLLAELLEN
                     ATSFSSPQTKVRVTGHALPDGRVLIGIDDAGIGLSAEDLADINERLAAPPTVDAAVSHR
                     MGLFVVGRLSLRHGVRVQLRGNGHGGTEALVMLPVDAVHAEGEGAPAPAPAPDGAGDDA
                     GGGAGGGG"
     misc_feature    complement(8002..8014)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.34"
                     /tool="antismash"
     gene            complement(8268..9863)
                     /locus_tag="RVR_RS04420"
                     /old_locus_tag="RVR_1244"
     CDS             complement(8268..9863)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013508.4"
                     /locus_tag="RVR_RS04420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1244"
                     /product="hypothetical protein"
                     /protein_id="WP_202232583.1"
                     /transl_table=11
                     /translation="MSTHRWRRWAATLAAAAVTLVGGALATGPAHADEGSAPYLFAGTP
                     VGLAVPDDGDGQVSWGLDSQGATLHDVHVTVDITGISSFATSSDDYCAGGLCTFDRGDV
                     GPSGTGGIVDIRALPGAALGAGGTAVITATAAGVTFAPFTVKVTVGRVDLVVDTLQRID
                     DAAPGSTLTEPLTVANVGSLTAATTDYRLALSPGLSFATRFPNCDYTDSTAEGWEATVA
                     TCHFSRPVEPGRKYRLSTPLTIGVKKSALHEIFSYAPTATSTAVPAAPRSAGAGDLTLV
                     PDGSAPSGGSGRQAQQNIDAANTADIALTGDTATARPGDTATLTATAANRGPATVDRYT
                     FDDELTVMVDIPKGTTATQVPAGCVPWDNGTRDPALGAPRYQCDLDGVFDSGHTQKLTF
                     KVKVGADAPATTSGTLVAQLADQGALPYDDHLADNKAAFTVKVPGGASTGTGSTGGAGG
                     GNQGSTQTGTASGSSGDSGTTGTTGGGAPSATGSLAHTGSNGAIPLALASLAALAVGGA
                     ALALTRTRRTRPRP"
     gene            complement(10001..11581)
                     /locus_tag="RVR_RS04425"
                     /old_locus_tag="RVR_1246"
     CDS             complement(10001..11581)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="RVR_RS04425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1246"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_202232584.1"
                     /sec_met_domain="PF00881 (E-value: 5.9e-10, bitscore: 38.2,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTISSVPTAAGALAVGLSLPAHWELVRVDRRLALRGPGGAADLGE
                     TDAEVEAALRGALAGTAVPERAEDVLLDDPDPGTAVARIARFRRLLASLSPHAVRHLLT
                     DDGELARAVPMTEPVPDAPADVAPGAVVRLSRAVVLRADQGVTVAETALRGLRVLVPDP
                     RAVALLGTLSAPAVWDAPPDPRCGLSPEAVREAVRWLAAFGLLAVADADGRFAEDLGPL
                     GQWSANDLHLHTRSRLGWDDRPYGATFRLLGTTEPQPAVRARHSGRTVELRRPAHLRAR
                     PDEPSFSEVLEARQSIRRYGPRAMSVGQLGEFLFRSSRTRARYGPYPERGMPYEAADRP
                     YPSGGGAHDLEVYVTAHRVEGLDRRVYHYDAWRHQLVEVCDEKPVIDALVATAVQSKGD
                     DAPDAVLTVTSRFSRLAWKYERIAYATTLRNVGVLYHTFYLVATVLGLAPCGLGGGDAG
                     LVARATGNDPLVEGSVGDFALGSLPTGRSLATERDRTQRGDPRWTAGQAPEWCQVRREV
                     IGDHPLDLA"
     misc_feature    complement(11566..11581)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            complement(11679..13979)
                     /locus_tag="RVR_RS04430"
                     /old_locus_tag="RVR_1250"
     CDS             complement(11679..13979)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Goadsporin_CD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cyanobactin_D_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NHLP_CD_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="RVR_RS04430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1250"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_202232585.1"
                     /sec_met_domain="Goadsporin_CD_RRE (E-value: 2.2e-22,
                     bitscore: 77.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="Cyanobactin_D_RRE (E-value: 4.5e-16,
                     bitscore: 57.4, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 3.9e-19, bitscore:
                     67.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 1.8e-90, bitscore: 302.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 2e-78, bitscore:
                     262.5, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTERTPGRRVVRFRPHLAVDVVPGEAVYLFAEDTAYAVHGSAVVD
                     LAPFLLGKHTEDEIVTALSADHAPEIVYHALGRLRARGYVVEADASLNPAEVAAWETAG
                     FDGEAVQPLLEALTCEIRTVGEVDAEPLRRALADAGARVVEHDAALLVVLADDYLNPRL
                     EEVNRSALSSGRPWLLARPAGAAVWIGPVFEPGAGGCWECLAFRLRRNRMVETYVEERT
                     GRRYVPAQAATATGTLLAAHLVALRALRWAARGAWTGGGDGAPEPGHGHVEVVRPLTAE
                     RVEHPHAHRPQCPSCGDPGTQARRGESPIVLAPSVPAVARDGGMRAVDGKELMTSLERL
                     ISPITGVVSGIEEFTTEDPRMPADLLHTCVAGQNFALGATGLDALREGIRSRAAGKGTT
                     ALQARVGAACEAIERYSGLYHEDEARITATYRELGDAAVHPNAVAGYSAAQYADRQRWN
                     STGSTFTVVAVPFDEDARLEWSPLHSLTGGPTRWLPTMQLYYFYPKHARTLYAWADSNG
                     CAAGTTPEDALLQGLMELFERDAVAIWWYNRLRRPAVDLASSDDPFVARCVDAYRAVGR
                     ELWVLDVTSDLGVPAFTAVSRRVDKPVEDILLAFGAHLDPAIALRRAVSELNQFLPAVL
                     DVGPDGGGYRFPDPVQMHWWRTARLADHPYLAPDPDAAPVRLDAFPRQSGSDIAVDLRH
                     AVDLCTKAGLDAYGIDMTRPDIGLPVFKAVVPGLRHFWARFGPGRLYDVPVRMGWLDAP
                     LPEQQLNPVPMFL"
     aSDomain        complement(13668..13958)
                     /aSDomain="Goadsporin_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     goadsporin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_RVR_RS04430_Goadsporin_CD_RRE.1"
                     /evalue="8.70E-25"
                     /identifier="RREFam013.1"
                     /label="RVR_RS04430"
                     /locus_tag="RVR_RS04430"
                     /protein_end="104"
                     /protein_start="7"
                     /score="77.7"
                     /tool="antismash"
                     /translation="RRVVRFRPHLAVDVVPGEAVYLFAEDTAYAVHGSAVVDLAPFLLG
                     KHTEDEIVTALSADHAPEIVYHALGRLRARGYVVEADASLNPAEVAAWETAG"
     aSDomain        complement(13677..13955)
                     /aSDomain="NHLP_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     NHLP/Nif11 LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_RVR_RS04430_NHLP_CD_RRE.1"
                     /evalue="1.50E-21"
                     /identifier="RREFam015.1"
                     /label="RVR_RS04430"
                     /locus_tag="RVR_RS04430"
                     /protein_end="101"
                     /protein_start="8"
                     /score="67.2"
                     /tool="antismash"
                     /translation="RVVRFRPHLAVDVVPGEAVYLFAEDTAYAVHGSAVVDLAPFLLGK
                     HTEDEIVTALSADHAPEIVYHALGRLRARGYVVEADASLNPAEVAAWE"
     aSDomain        complement(13722..13955)
                     /aSDomain="Cyanobactin_D_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing D protein in a cyanobactin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_RVR_RS04430_Cyanobactin_D_RRE.1"
                     /evalue="1.70E-18"
                     /identifier="RREFam007.1"
                     /label="RVR_RS04430"
                     /locus_tag="RVR_RS04430"
                     /protein_end="86"
                     /protein_start="8"
                     /score="57.4"
                     /tool="antismash"
                     /translation="RVVRFRPHLAVDVVPGEAVYLFAEDTAYAVHGSAVVDLAPFLLGK
                     HTEDEIVTALSADHAPEIVYHALGRLRARGYVV"
     gene            complement(13976..16666)
                     /locus_tag="RVR_RS04435"
                     /old_locus_tag="RVR_1251"
     CDS             complement(13976..16666)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024964.4"
                     /locus_tag="RVR_RS04435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1251"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_202232586.1"
                     /sec_met_domain="DUF4135 (E-value: 1.6e-50, bitscore:
                     171.1, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSLPSPPGAAAPSPSGAAAPSPSGAAFPSPSGAAFPSPPVARAV
                     TAPGAGPVLRGLGDLADVLATVIAAGAPPADRAAAGPAAVLDDAARRRAAQWAAAATGT
                     SDLDAPAVRAAVAAGALGAGDVLAAHAGIDPARLTALPAWARELALLLRALPDRSTGDD
                     GLWAPQRCMREATRILLLADLAALRAAGRAPELTERAEADLAAQGADRVLAHCGPALDF
                     DLRFLRPAEIDGSRGDWCRRLAALPVLGFLVGTAVRQWRAATREMLTRLAADRDVLAEG
                     LFGQVRAAALDRVAADAGDPHDDGRNVAVLTFACGRRAVYKPRDLSCAAAFLRLLDETA
                     DAFPDRPPHRRPLLARDGYAWEGYVERGACSAPDELADYPRHLGRLIRLATLVQARDLW
                     QDNLRPCGALPVVLDLETVMHPVFATGTDDPVEAALADTALPTGMVTAPVLLRPGGPAV
                     DVGGCSPADRKPVPFRPEVPRLSEHGRDLGLLDGALTWQPESMAWYGDQVLDPREHTAA
                     VAAGYREADTALARSAERLTAPGGAGHAFDGTTVRVMWSSTWASFTTMRAAEAPQALTG
                     FERREAVLARVLRAELAHGADPATPATAGRIALAAASVADLRRLDVPIFRTVVGGTDIL
                     TSTGRRVPGLLAPGGGAALRSRLLRARQGPDPVGDAVLRTCQHLVDVHTGHRRPVPPHP
                     AHPPVGADDDDLLRLAGHLLDRAHRAAIPDSGGGSHWMGLRHEPALGITVLATDGAAPA
                     ALRHAAEELARARAARDRRGSGRAQAAPGEPGAAPGRYCALGSDALLAAGERAAAAAAS
                     PGGAAGERGAARRTLREIGWEFAARAAHGSCLPDRTAAEEHQLGAGDGLPAVVLALLRA
                     AGHPVPPPARTPSSAGPTSPPRSTR"
     gene            complement(16663..18780)
                     /locus_tag="RVR_RS04440"
                     /old_locus_tag="RVR_1252"
     CDS             complement(16663..18780)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="RVR_RS04440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1252"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_202232587.1"
                     /transl_table=11
                     /translation="MSAAASPLSPLDRFRAGAPVSAAPPRGCVEEVAAHLGAAPAADRS
                     GTRDEEGPADVQGAFEALGLRARVVTLADDWHRTPLHPLLGYWRDGSPVALLPRGRSFR
                     LVLPGHGAIGRVDAATAADLTPWAWEVTRPLEARRARDLAAHGRRRGDLALLLAAGLAA
                     AVLGAFLPSAGALALSAVLGDRTGLLGELAVLAGFGLGVYAGLVWLRNLVLARLESYAE
                     AVLGPAALDRLLRTRAWRLREYTAGDLAVRVAGVDAVRQMLGNTTLSALLNLLFGAASL
                     VVVIVLAPLPSLPALALVLAAAALSGWFGMRQLRHDRRVFALYGEASSTLLEMLRGLDK
                     IRVAGREERAFGRWLEVFAEQKRQDLAAVGWQSAASGLTAALPGLLYALLLGAPLLLGT
                     AYPGAGGLLALNIALTQFIGSVGQAGRIATAVFGVVPVVDRLLEVVGLEAEPAGAAVPP
                     ARRLALRGVGVRAPGGAALLRGVDLDVGPGEFVGVVGASGAGKSTLVQALLGLVPLAEG
                     EVRFDGRRLDGLDPVSARRSLAAVLQDATATGTDIRSTVAAGRPGIDDAAVWAALDGVG
                     LTDEVRAMPLGLATPVGAGNRMVSGGQRQRLLVARALAGRPRLLVLDEATSGLDPATEV
                     ALLGRLAEAGPGRIVVTHRVESLAAADRILVLEDGLPVAVGRYAELVTGCPAFARLLDP
                     VGAATGREGAR"
     gene            complement(18777..20978)
                     /locus_tag="RVR_RS04445"
                     /old_locus_tag="RVR_1255"
     CDS             complement(18777..20978)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="RVR_RS04445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_1255"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_202232588.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4e-25, bitscore:
                     86.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRTLRVPYVPQAEETDCAPACLASVLACHGRRVPLRDLREATGA
                     SRDGVDALTWLRAARDQGLRASAVRITVPWRDGVPDPSGLATVALPVVAHLADGHFVVV
                     ERVRGDLVTVVDPAIGRHRMPFAELAPELSGVLLTAQPGAEFTRGGPRGTAGRRLAAAL
                     AAQWPGVLCAVALSLVGGAMSLLLAMVLKLLAADAVSGGSGGGLRLYAVTVAVGLVSGL
                     AVAAQNQLLGRLQVRQSLTMSVDLVWRLLHIDGRTLLRRDPGAMAARAQAVDAFSLGLV
                     HQLVPAAGAVVNAALLGTVIVREDSVVGGLAVGLGLLVVGVPLTSWRRQSAAALVEARL
                     TACRDAAGFAALRALDAVKAGGGEAEVTGRWSSLHAVAVRATSVHNRQQQTLTALPAVL
                     TVGASSLVVLAAAPRILHLHMTLGALFAVQSLTGGFTAAAATAVGGLLAVPGLLTRIGL
                     LDDLLAEPYDPSAVRTVEPDTGARAGGSLRMEQVTAGYAPGRPVLREVDLDVAAGEWVA
                     ITGPTGAGKTTLARLAAGVLAPLTGRVLLDGRPSDERPRGELVRSVAWVDQTIELFAGT
                     VAENVALWDETVSDEAIERAVHDACLDRVVELRGGCHRAVVDEGGANFSGGERQRLEIA
                     RALACDPSLLVLDEATGALDRAVEQQLFARLRRRGVTVVMLAHRRSAVRACDRELVVRE
                     GRVTPSGPAPTGPPGGTPPAGRSATGPLAGARAARVGDR"
     gene            complement(20975..21970)
                     /locus_tag="RVR_RS04450"
                     /old_locus_tag="RVR_1256"
     CDS             complement(20975..21970)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS04450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_1256"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_202232589.1"
                     /transl_table=11
                     /translation="MSEHGRGTADDARGAARTGRVAAAEAEHGVEADGTAGTGAPGGQE
                     TAAEEKATAEQEAIAGQEAAAEARAQERLASAARIAGQRMTLVPPGLLTALAVVLAAVA
                     GLVSWAAIGTVQSTVRLEGVLVHGSGPRPVASPVTGTVLSVDVAPGDAVRSGQRVGQVA
                     VAGGGTRAVLAPVDGSVLGIVSAPGTAVSPGTPVVSVDSGSGGLRAWMFLGSDRGFPVT
                     EGAAVSAQLSSDQSAVSVSGEVGSVGRYPVTAAEVSRMLGGLSASLAVSGHGPYRLVTV
                     DLHDALVAGAARIGLGSGDVASQLPALVPVIARVRTGSVHPLDELTGGHW"
     gene            complement(21970..23247)
                     /locus_tag="RVR_RS04455"
                     /old_locus_tag="RVR_1257"
     CDS             complement(21970..23247)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS04455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_1257"
                     /product="cytochrome P450"
                     /protein_id="WP_202232590.1"
                     /transl_table=11
                     /translation="MGETANPTSAAVGEVLACLAGRRPTLSPSVARRWPALHAGTGLTV
                     VARADAAREALGDPRLVVGDGDGRLPALRISPHDDLDAVFRAMPSLRDGSAHARLRRLV
                     APYFTRRRASAARAAIAEAVERTWPADAGEGFDFVSGYADRLPVRLALLVMGLPAGDAD
                     ELERWARLLRDRIGPGAGPSGEEADALAGELAALRRYVRGALAAADGGPLYAVGEAVRT
                     GTADEAEGFALFVLLLTAGLETLSQALAQAAHRAAAEPELLARLREEPDRAHDAFRSTL
                     RAASPLRMLARRAACPASVGGLALPAGQTVVLLLASALAGEDAGPGPRTGPEAALAYGH
                     GPHICLGMHHADLAGAEFLRFLAGRPGRLALLPGAVPHRSPAVQGWSRLPVRELPPEPE
                     PEPDPTPAPGGRESAHDGANRPAGGE"
     gene            complement(23331..23657)
                     /locus_tag="RVR_RS04460"
                     /old_locus_tag="RVR_1258"
     CDS             complement(23331..23657)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS04460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_1258"
                     /product="hypothetical protein"
                     /protein_id="WP_202232591.1"
                     /transl_table=11
                     /translation="MSDIQLTAEERRSFGALVAQLWSDEELATRYRDEPVAVLAEYGIS
                     AQEALPVPPAPVEEISDESLGLLGAVGGLSTCGSASSFSCPGCTASTVGSGTCCGSQPT
                     LPVS"
     misc_feature    complement(23656..23670)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
ORIGIN
        1 acgtgccgcc gggcctcttc ccgcggccgt tcgcggtcag gcgtcggctc ctgcttcggc
       61 gtggcgggtg ccggagtcgg ggccgtgcca gtccaggcag atcacggtgg cgtcgtcctc
      121 catgtgcccg tcgcaggcgt cgatgaccgc ggcggtcagc gtgcggaccg cttcccgcgg
      181 gtggtcggtg gcggtgtcgc ggaccagacc gcgcaggtcg acgctcttcg cccggcgctc
      241 ctgcatgccg tcggtgtaca gcaccagccg gtctccgggg cgcaggtcga tgtcctggac
      301 ccggtagggg tcgcgcgggt gggccgggtt gaccccgaag ggaaggtcgg cgtccaggtg
      361 gatctcgtcg acgacaccgt cgcgcaggcg gagcggccag gggtgcccgg cgttgacgag
      421 gtgggcgccg gtgccgtcca gcgcgatgcg catgagctgt ccggtggcga aagtgcggcg
      481 gccgtggtcg agcatggcct ggtggacctg ccgcgcctgc tcggcgaggt cggctccggc
      541 gcggcgggcg ccgcgggagg cgttgaccag gagggtggcc atcagcgagg cgtcggtgtc
      601 gtggcccatc gcgtcggtga cggacaggtg gagggtgttg cggtcgagcg cgtagtcgta
      661 ggtgtcgccg gcgatggagt cggcggggac cagggcggcg gagagggcga actcggcggc
      721 ctcgcaggag ggggccgacg gcagtagctg gcgctggatc tcggcggcca ggctcatcgt
      781 ggtggtgcgc tggacccagt ggtagatgtc ggtgaagcgg ccgtcggtga cgacgatgta
      841 cgccagcgcg tgggcggcct ccgcgacgtg tgcgaccgcc tcggggctgg ggtggggaag
      901 ggtcagctcc agcacgccga gggtgtcgcc ccggttggtg accggggcca gtacccgccg
      961 gccgcctccg ctgtcctccg cctcgaccac ttcctgggag cgcagtacct cctcgtacac
     1021 gctgcccgcc agggggatct gctccgcgcg gcggccctcc tgtgtgtccg gtgcctcgct
     1081 gacccgcacc aacttgtggc ccacgacgtc gacgaacagg aacgacacgt accgcgcgcc
     1141 gaatcgctcc cgcaggttcc gggccaccac gtccacggac cccaccggag cggcgtcctc
     1201 cgccgcagcc aggatgtcga ccagtccgat ctgctcccgc gccatgacaa cctcccaggc
     1261 agtagatcat tctccttccc gcaagtgcct ccgcatcact cgatcccacc ggaaaggcca
     1321 ctcccgcgcc gacccgggag cggccgtccc gtgatcccaa ggccgcgatc ctgtcccacc
     1381 cgccccacgt atcccctccc tgtcggcggg aagaggcgtc ggtccgatct ttgctgcggg
     1441 atgccttgac ccttggttac aagcaggtta gaaagtggtg cgccaaacag aaatatgcat
     1501 tcaacatatg aacgagcgca tcgcgtcacc atccggcgga tccgtggaac aggtctgctg
     1561 agggggtgtc agggttccgg tgcgcggatg cttttccgtt ccggcgcgct tacccgtcgt
     1621 ttcgattcgt gaagggaaga cacgcgaagc gacgccggtg gccaccctca ggcccagccg
     1681 gctccgtcca cccgagcgat cgacggagcg gcggccccac cctcagcgtc gaggagcaca
     1741 cgtgcccaga atgtcccgac gggtcaccct ctcggtgtcc gctgccaccg tggcggcagc
     1801 cgtcctcgtc ccggtctcgg ccggcgcaca gacccccaac tccccttcgg cgtcccccaa
     1861 gctgggggtc accgtcaccc acaccggcaa ggggccgacc ggataccagg ccaccttccg
     1921 gatcaaggcc cccaccgcga cgtccatgca gatcaagggc gaatggggct tcgcgtcctt
     1981 cgagagcgtc gaggccgact cctccaacgc gcacccggtc gccccctccg actggaagcc
     2041 gggtgacttc ccgctggagt cgccgaactc ccctggcggc tactggcccg tcgccagcat
     2101 gacggaggac accaagacgg gggtctggtc ctacaccaca ccgctcccgt ccggcgtgtt
     2161 cacgtactcc tactacgcga actgcaccgc cgccgccccc gccctgaagg gctgcacggg
     2221 gacctcggac ccggcgaacc cgccgtggaa caccaccacc ggctcgaccg aggcgaacag
     2281 ccaggtctac gtgccctccg accccaagtc cggtaccgct gacgcgtcct gggaggccga
     2341 cgccccggcc ggccagcggg gcaagctcgt ggacgtggcc tatccgaccc ccaacaccgc
     2401 cacggggacc caccctctcg cggtctacac ccccgccggc tacgacccga agcgcaagac
     2461 gccctacccc gtgctcgtcc tcacccacgg gggcgggggc aacgagatgg actggtcgac
     2521 ccagggccgg atgcagcaga tcgtcgacaa cctcacccgc accggcaaga tgcagccgac
     2581 cgtcatcgtc atgcccgacg gcggcggcct gacctccggt gccagcttca cctccgaggt
     2641 cgccgaccag atcctgccgt acgtcgagaa gaactaccac gtcggcacga gcgcgaacga
     2701 ccggtccttc gccgggctct ccgcctacgg gacccaggcg aacaacttcc tgttcaccga
     2761 cacctccgag ttcggctact acggcgtctg gtcgcccgcc gccggcgcgc ccggtgtcgt
     2821 cggcaacggc tcgggcaacc cggtcctgga cgccgactac accaaccccg ccctcaagca
     2881 ggtcctcggc atccacctcg ggatcggtgc ggaggacctg ggcggcaacc tccccgccct
     2941 caccgccgtc accgagcggg tcggcatgct caacgccggg gtgcccttca ccttctacac
     3001 caccggcggc ggccacacct gggacttctg gcgccaggcg ctgcgcgact tcctgaccaa
     3061 ggtcgacttc cgcgccacca cgaccaccgt ctcgaccacc accgccaaga acaccgccaa
     3121 ggcgaccgcg tcggtctccg ccgccacgga cgagcccgtc gcacccaccg gaaccgtcca
     3181 gttcaaggtc gacggcaccg acctgggcaa gccggtcaag ctcgcgggcg ggaaggcgac
     3241 cgtgagcgcc accgcgtcgc aactgtccgg acacaccatc accgccgtct acagcggcgc
     3301 caccacctac aaccccagca cgagcgcggc ggtcaccggc tgaccttcgc tgacgccgac
     3361 cgggccacac ccgcaagggc gtggcccggt cccgtgcgtc cgcggtcgac ggcggagccg
     3421 ctgcgaccgg acagcgaacg cgcgggcgcc aggggggcgg cccgggggcg tcgggggtgc
     3481 ggcgtcgcgt cctcgggggc tacgcgtcgg cgtcgccggc ggcgagggga aggtaggtgc
     3541 cgggggtctg gccggtgacc cggcggaacg cggcgatgaa cgcgctgggt ttgcggtagc
     3601 cgaccgctcg ggcggtggcg ttgaccgagg tgccgtcggc cagcatcggg acggccgccc
     3661 ggatacggac gtgggcgcgc caggtggcga aggtgaggcc ggtctcggcg cggaacagcc
     3721 gggacagggt gcggacgccg gcgtggacgt ggtcggccca cgcggtgagt tcgcgcgggt
     3781 cggacgggtg ggcgacgagc tgttcggcga ccgcgcgggc ccgcgggtcg gcgggcatcg
     3841 tgacctggat gtggtgcgcg ggcagcggcg tgagcagctc gaacatcagc gcctcggcgg
     3901 ccgcacggct gtggtggtcg ggggcgacgc ggtgcaggtg ggtgatgatc tcgcgcagca
     3961 gcgggccgac ggcgaagcag gtgggcccgg tccagtccag gggccagcgg tcggcgtcga
     4021 aggtgatggt cagcatctcc cccgcgcgca gcacggcgcc ggcgtgctcg acgccgccgg
     4081 gcacccagaa cccgtagccg ggcgggatga gccagtcacg gcgggcgacg gtccccatca
     4141 gcgtcgcggt cgagctccac gtgagcatcg gttcgggatg cgcgtgcagt tggagcagtt
     4201 cgtggtcccg ggcgatgtcg cggtcgatgc acaggatggg ggagaccgcc gtcgacaccg
     4261 ctcccgcgcc cggcgggtcc gtaccgaccg gcggctccgt accgcccacc gggtccgtac
     4321 cgcccaccgg ctccgtaccg accggcgggt ccgtcatgcc cggcggccgg gggccctccg
     4381 gcgcaccgct cgcggtccgc cgcaccgggt tggccggttc ggggtatcca ttggcctcta
     4441 cgcgcacagc ggccagccta gcgtgggtga cccgacgtga ggagtgcgtg gctgatgaac
     4501 gacgtgaggg tccgggccgg gggcccggtg gagcggtacg ggccggccgc ggcggcggcc
     4561 ggaagcgacg cggcgcgcgg cgcgagggcg gtgcgggcat gaccaccccc gccgaaccgt
     4621 tctcccccgc actgcgccgg tcggtggggg tggtgatgat cggcgcgtcc ctgtccttcc
     4681 tggactcgac ggtcgtcaac gtcgccctgc acaccctctc ggtcgacctg cacgccgggc
     4741 tggggacggt gcagtgggtg gtgaccgcct acctgctcgc cctcgcggcg gtcatcccgg
     4801 cgaccggctg ggcgggccgc cggttcggcg ccgcccgggt gtacgtcgcc gcgctggcgg
     4861 tgttcaccgt ggggtcggtg ctgtgcgcgt gcgcgccgac cgccgggacg ctcatcgcct
     4921 gccgggcgct gcaaggcgtc ggcggcgggg cgatcatgcc ggtcggcacg atgatctgga
     4981 ccgcgcagtc ctccaaggcg cagatgggga aggtgatgag cctgatcgcc atcccgatca
     5041 tcctcgctcc gacgctcggc cccgccgtcg ggggtctgct catccagggc atcgactggc
     5101 gggcggtctt ctggctgaac gtccccttcg gggtcgccgg tgtcgtgctc gccgtccggc
     5161 tccttccccg ggaggagccg caggtgcagg ggggcggcgc gggacggctc gacgtgaccg
     5221 gcctggtcct ggcctccgcc gggatcgtgg gcgtcaccta cggcctggcg gaactcggcg
     5281 ccgcggccgg cccggacacc gccgccgccg tcgccctgcc ggtcgggctg gccgccctgg
     5341 ccggattcgc cgcacacgcc ctgcgggcgc agcggccgct gctcgacctg cggctgtacg
     5401 gcggccgcgc gttcaccgcc gcgtcggtcg ccacgttcgc cctcggcgcc gcgaacttcg
     5461 gcgggatgat cctgatgccc ctgtacctcc agaccgtccg cggcgacggt gtggtcctgg
     5521 ccgggctcct gctcgcgccg accggactcg gcgcgctgct ctcggcaccg ttcaccgacc
     5581 gctacggcgc cgggatcacc gccttcaccg gcgccgccgt cctggcggtc tcgaccctcc
     5641 cgttcgtctt cctgaccgcc accaccccct acgccctgat ctgcctggtc atggtggtca
     5701 ggggcgtcgg gttcggcctg tcggtcatcc cggcgatgac cgccgcctac cgtgccctgc
     5761 cgccggacaa gatccccgac gccaccccgc agctcaacgt cctccaacgc gtcggcggcg
     5821 cgatcggcac cgcggtgctc accgtcatcc tcaacggccg gctccacggc caccccacac
     5881 ccgccgggcg ggcggacggc ttcgggacca cgttcgtctg ggtgctcgcg atcacggtcg
     5941 cggccgccgt gccgaccctc gtgctcgccc gcaccgaacg ccgagcccgc cgacgcgcgg
     6001 acgcgccccg gcccgaaccc ggacccgagg aggtcgccga ggccacccgc tgaccccctc
     6061 agccgccgcc cccggcgccg ccgccggcgt cgtcccccgc gccgtcgggt gcgggtgccg
     6121 gggcgggtgc gccttcccct tccgcgtgga cggcgtcgac gggcagcatg accagggcct
     6181 cggtgccgcc gtggccgttg ccgcggagtt ggacgcgtac gccgtggcgc agcgacagcc
     6241 ggccgaccac gaacaggccc atccggtggg agaccgcggc atccacggtc ggcggggcgg
     6301 ccagccgctc gttgatgtcg gccaggtcct ccgcggacag gccgatcccg gcgtcgtcga
     6361 tcccgatcag cacccggccg tcgggaaggg cgtggccggt gacgcgcacc ttggtctgcg
     6421 gcgaggagaa cgacgtggcg ttctccagca gctcggcgag caggtggacg aggtcggtga
     6481 cgacgcggcc ggcgacctcg accgccggca ccgaggtcag ctcgatccgc tcgtactgct
     6541 ccacctcgga cgcggcggcg cgcagcacgt cgaccagcgg gaccgggctg gtccaccggc
     6601 ggccgggctc ctcaccggcg agcaccagca ggttctcccc gttgcgcatc atgcgggtcg
     6661 ccaggtggtc gagcttgaac agcgacgcga ggtgggcggc gtcggcctcc tgctcctcca
     6721 gttcggagat gagggagatc tgccgctgga ggaggccctg gctgcggcgc gagaggttgg
     6781 tgaacatcgc gttcacgttg ccccgcagca gcgcctgctc tcccgccagc cgcacggcgt
     6841 catggagcac caggtccatg gcggcggcga cgcgggcgat gtcgtcgtcg ctgtacgtgc
     6901 tcgccggaag gggcagcagc gaggagaggt cggcgtcgag gacgtccccg gcggagaacc
     6961 ggccgaccac gcggggcagt tcacgcgcgg cgtgctcggc ccgcgcgcgc agcgtctcca
     7021 ggtccgtccg ctgccgcctg cgcgtccccg cgcgccgtcg ccgccaccgc ccggccttcg
     7081 gcgggcgcgg ctcctgcgac cggccgggat cgggaccgtc cggactgccc cagcggctct
     7141 ccaggtgctc gtccagcacc cgttcggcgc cgtgcagctc ggtcgcgagc tgctcgcgcg
     7201 cctgggcgat ggcgtactgc tcccgcatgg ccgagaccag ttccgccgag tgctgctcca
     7261 tcagcgcggt gagcatgtcc cgttcggcca gggcgcgggc gcgttcgcgc cggagggtgt
     7321 cgacgtcgtc ggccggtccg gtccgcgctt cgagctgccg caggctgttc tccaccagtt
     7381 cccgccgccg ctgctcggcg tggagttcgg cctggagttc ccacacggtc tcctcggcca
     7441 gctcggcccg ctgcaccgcc cgggccaggg cgtcgcgcag catgtagacc tcgtgccgtt
     7501 gcggctcgtg gaccaggcag gccgcgaggt acagctcccg taccgactcc cgcacgtcct
     7561 tgtgcatgcg ggtctgcgtg cggctgaaga ccgcgtcgtc gagcttgccg aggaaggcga
     7621 tctccggcag gcggcgcccg ttgaggtagc gcgacagcgt cgtggcgtcg atccccacca
     7681 ggcgttccag ctcgccgagc gtcatgccga ggctggtgta gaactcccgc agccggttgg
     7741 cccacgcggt catctccggg cccaggtcgt tcctcagcgg actgagcgga cggcctcgac
     7801 gtggttcctg catcccccgc aacaactccc ctctgccgtc atcctgccag gaattgttgc
     7861 cgccccgcgg cacgaacgct gtctccgctg gtgcaagaaa tccggccttg cgaggttcag
     7921 gtgcggaagg acgcgcacga gaaccatgga ggacgaggga tgaacaccgc aggtcagtac
     7981 ctcgagttgg gaggagcggt cctgcaactc gcaacggccc tgatcggggc gttcggcccc
     8041 cggccggcac gccgcaggcg ccggaacagg aagccggccg gcaccaggag gtcctgagca
     8101 cgcaaggggg gcccggcgcg acgcgccggg ccccgggcaa agcaggtcag gacacaccct
     8161 cgcaggagca gccgccgggc cacgggctcc cgtaccgggc gcggtccggg gagcactccg
     8221 ggagcgggca ccggtatgtc cgcgaccgcg gcggccgggc ggggcggtca gggtcggggg
     8281 cgggttctgc gggtgcgggt gagggcgagg gccgcgccgc cgacggcgag ggccgcgagg
     8341 gaggcgaggg cgagggggat cgcgccgttg ctgccggtgt gggcgagcga gccggtggcg
     8401 gacggggcgc cgccgcccgt ggtgccggtg gtgccggagt ccccggagct tccggacgcg
     8461 gtgccggtct gggtggagcc ctggttgccg ccgcccgcac cgccggtgga gccggtgccg
     8521 gtggaggcac cgccgggcac cttcacggtg aaggcggcct tgttgtcggc gaggtggtcg
     8581 tcgtagggaa gggccccctg gtcggcgagt tgggcgacca gggtgccgct ggtggtggcc
     8641 ggggcgtcgg cgcccacctt caccttgaag gtcagcttct gcgtgtggcc gctgtcgaag
     8701 acgccgtcga ggtcgcactg gtaccgcggc gcgccgagcg cgggatcgcg ggtgccgttg
     8761 tcccacggga cgcacccggc gggcacctgc gtggcggtgg tgcccttggg gatgtcgacc
     8821 atgaccgtga gttcgtcgtc gaacgtgtag cggtcgacgg tggccggccc ccggttggcg
     8881 gccgtggcgg tgagcgtggc cgtgtcgccg gggcgggccg tcgcggtgtc accggtgagg
     8941 gcgatgtcgg cggtgttggc cgcgtcgatg ttctgctgtg cttgccgacc ggagccgccc
     9001 gacggtgcgc tgccgtccgg cacgagcgtc aggtcgccgg cgccggcgct cctcggcgcg
     9061 gccggcaccg cggtggacgt ggccgtcggg gcgtaggaga agatctcgtg cagcgcggac
     9121 ttcttcaccc cgatcgtcag cggggtggac agccggtact tcctgccggg ctcgaccggc
     9181 ctggagaagt ggcaggtcgc gaccgtcgcc tcccagccct cggcggtgct gtcggtgtag
     9241 tcgcagttcg ggaagcgcgt cgcgaaggac aggcccgggg agagcgcgag ccggtagtcc
     9301 gtggtcgcgg cggtcagcga gccgacgttg gcgacggtga gcggctcggt cagggtgctg
     9361 ccgggcgcgg cgtcgtcgat ccgctggagg gtgtcgacga ccaggtcgac cctgccgacg
     9421 gtgaccttga cggtgaaggg ggcgaacgtc actccggcgg cggtcgcggt gatgacggcc
     9481 gtgcctccgg cgccgagcgc ggcgcccggc agggcccgga tgtcgacgat gccgccggtg
     9541 ccgctcgggc cgacgtcacc cctgtcgaag gtgcacaggc cgcccgcgca gtagtcgtcc
     9601 gagctggtgg cgaaggagct gatgccggtg atgtcgacgg tgacgtgcac gtcgtggagg
     9661 gtcgcgccct gcgagtccag cccccaactg acctggccgt caccgtcgtc gggcacggcg
     9721 agcccgacgg gcgtcccggc gaacaggtac ggcgcggacc cctcgtcggc gtgggccggg
     9781 ccggtggcca gcgccccgcc gaccagggtg accgcggccg cggccagggt ggccgcccat
     9841 cgtcgccatc tgtgcgtgga catcatgcgg tctcccccag gaactcacgg agtacggctt
     9901 cgggacaccc ctttcgacct ccgggcgccc cggatggttg ccccggcggt ggcacagggc
     9961 gtcggcgccc tgtgccacgc gccgcgccgg ggcgcgccgt tcacgcgagg tccaggggat
    10021 ggtccccgat cacctcgcgg cggacctggc accactcggg cgcctggccg gccgtccacc
    10081 gcgggtcgcc gcgctgggtc cggtcccgct ccgtggccag cgaccgcccg gtcggaaggc
    10141 tgccgagggc gaagtccccg accgatccct ccaccagcgg gtcgttcccc gtcgcccgtg
    10201 ccaccagtcc ggcgtcaccg ccgccgagcc cgcacggggc gaggcccagc accgtcgcca
    10261 ccaggtagaa cgtgtggtag agcacaccga cgttgcgcag cgtggtcgcg taggcgatcc
    10321 gctcgtactt ccaggccagc cgggagaagc gcgaggtgac ggtgagcacg gcgtcgggtg
    10381 cgtcgtcgcc cttggactgc acggcggtgg ccacgagcgc gtcgatcacc ggcttctcgt
    10441 cgcacacctc gaccaactgg tgccgccagg cgtcgtagtg gtagacgcgg cggtccaggc
    10501 cctccacccg gtgggcggtg acgtagacct ccaggtcgtg ggcgccgcca ccgctcgggt
    10561 aggggcggtc ggccgcttcg tagggcatgc cgcgctcggg gtaggggccg tagcgggcgc
    10621 gggtgcggct gctgcggaag aggaactcgc cgagttgtcc gacggacatc gcccggggac
    10681 cgtagcgccg gatggactgg cgggcttcca gcacctcgct gaaggagggt tcgtcgggcc
    10741 gggcgcgcag gtgcgcgggc cgccgcaact ccaccgtgcg gccggagtgc cgggcccgga
    10801 cggcgggttg cggctcggtc gtgcccagca gccggaacgt ggcgccgtac ggacggtcgt
    10861 cccagccgag ccgcgaacgg gtgtgcaggt ggaggtcgtt cgcggaccac tggcccagcg
    10921 ggcccaggtc ctccgcgaag cggccgtccg cgtccgcgac ggccagcagc ccgaaggccg
    10981 cgagccaccg gaccgcctca cggacggcct ccggcgacag gccgcaccgg gggtcgggcg
    11041 gcgcgtccca gaccgccggc gcgctcaacg tccccaggag cgccaccgcc ctggggtcgg
    11101 gcaccaggac gcgcagcccc cgcagcgccg tctcggcgac cgtcaccccc tggtccgcgc
    11161 gcagcacgac ggcacgcgac aaccggacga ccgcccccgg cgccacgtcg gcaggggcgt
    11221 ccggcaccgg ctcggtcatc ggcaccgcac gtgccaactc cccgtcatcg gtgagcagat
    11281 ggcgcaccgc gtgcggggac agcgaggcga gcaggcgccg gaagcgggcg atccgggcca
    11341 cggccgtacc cgggtcgggg tcgtcgagca gcacgtcctc ggcccgctcc ggcacggccg
    11401 tgccggcgag cgccccgcgc agcgccgcct ccacctcggc gtcggtctcc cccaggtcgg
    11461 ccgcgcctcc gggcccgcgc agcgccaacc tccgatcgac gcggacgagt tcccagtggg
    11521 cgggaaggga gaggccgacg gcgagtgcgc cggccgcggt ggggaccgag gagatggtca
    11581 acgggggctc ccgacgggtc gggcgcttcc cggacgggaa gcgcgggggg atcggcgggg
    11641 cccggacggg cccgggcgcc gtcctgatgc cgggccggtc acaggaacat cggcaccggg
    11701 ttgagctgct gctccggcag cggtgcgtcg agccagccca tccggacggg cacgtcgtag
    11761 agccggccgg gtccgaaccg cgcccagaag tggcgcagtc cgggcacgac ggccttgaac
    11821 accggcaggc cgatgtcggg ccgggtcatg tcgatcccgt aggcgtccag gccggccttc
    11881 gtgcacaggt cgacggcgtg ccgcagatcg accgcgatgt cgctgccgct ctgccggggg
    11941 aaggcgtcca ggcgcaccgg ggcggcgtcc gggtcggggg cgagataggg gtggtccgcg
    12001 agccgggcgg tgcgccacca gtgcatctgg accgggtcgg ggaagcggta gcccccgccg
    12061 tccgggccga cgtccagcac cgccgggagg aactggttga gctccgagac cgcccttcgc
    12121 agggcgatgg cggggtccag gtgggcgccg aaggccagca ggatgtcctc gacgggcttg
    12181 tcgacgcgcc gcgacaccgc ggtgaaggcc ggcacgccga ggtcgctggt gacgtccagc
    12241 acccacagtt cgcggccgac cgcacggtac gcgtccacgc agcgcgcgac gaaggggtcg
    12301 tcggacgacg ccaggtcgac ggccgggcgg cgcagccggt tgtaccacca gatcgccacc
    12361 gcgtcgcgtt cgaacagttc catcaggccc tggagcaggg cgtcctcggg cgtggtgccg
    12421 gcggcgcagc cgttggagtc ggcccacgcg tacagcgtcc gggcgtgctt ggggtagaag
    12481 tagtagagct gcatcgtcgg cagccagcgc gtggggccgc cggtcagcga gtgcaggggg
    12541 gaccactcca gccgggcgtc ctcgtcgaac gggacggcca ccacggtgaa cgtggagccg
    12601 gtgctgttcc agcgctgccg gtcggcgtac tgggccgcgc tgtagccggc gaccgcgttg
    12661 gggtggacgg ccgcgtcgcc gagttcccgg taggtggcgg tgatccgcgc ctcgtcctcg
    12721 tggtagaggc ccgagtagcg ctcgatcgcc tcgcacgcgg ctccgacgcg ggcctggagg
    12781 gccgtggtgc ccttgcccgc cgcgcggctg cggatgccct cgcgcagggc gtcgagtccg
    12841 gtggcgccga gcgcgaagtt ctggccggcc acgcaggtgt gcaggaggtc cgcgggcatg
    12901 cgcgggtcct cggtggtgaa ctcctcgatg ccggacacga ctccggtgat cgggctgatg
    12961 agccgctcca gcgacgtcat gagctccttg ccgtccacgg cgcgcatgcc gccgtcgcgg
    13021 gcgaccgccg gaaccgaggg cgcgagcacg atcggggact ccccgcgccg cgcctgggtc
    13081 cccgggtcgc cgcagctcgg gcactgcggc cggtgcgcgt gcgggtgttc gacgcgttcg
    13141 gcggtgagcg gccgcaccac ctccacgtgg ccgtggcccg gctcgggggc accgtcgccg
    13201 ccaccggtcc aggcgccgcg cgcggcccac cgcagcgcgc gcagcgccac caggtgcgcc
    13261 gcgaggaggg tgccggtcgc ggtggcggcc tgcgccggta cgtaccgccg gccggtgcgc
    13321 tcctcgacgt acgtctccac catccggttg cgtcgcagcc ggaaggccag gcactcccag
    13381 cacccgccgg cgcccggctc gaagaccggg ccgatccaca ccgcggcccc ggcgggcctg
    13441 gccagcagcc acggccggcc ggaggacagg gccgagcggt tgacctcctc caaccgcggg
    13501 ttgaggtagt cgtcggcgag tacgaccagc agcgccgcgt cgtgctcgac gacgcgcgcc
    13561 ccggcgtcgg ccagggcccg gcgcagcggc tcggcgtcca cctccccgac cgtcctgatc
    13621 tcgcaggtca gtgcttccag cagcggctgg accgcctcgc cgtcgaagcc ggcggtctcc
    13681 caggcggcga cctcggccgg gttgagggag gcgtccgcct ccaccacgta gccgcgggcg
    13741 cggagccttc ccagggcgtg gtagacgatc tccggggcgt ggtcggcgga cagggcggtg
    13801 acgatctcgt cctcggtgtg cttgccgagc aggaaggggg ccaggtccac gaccgcggag
    13861 ccgtgcaccg cgtaggcggt gtcctcggcg aacaggtaga ccgcctcgcc gggcaccacg
    13921 tccacggcca gatgagggcg gaaccgcacc accctgcggc cgggggttct ctccgtcatc
    13981 gtgtgctcct cgggggtgaa gtcggtccgg cggacgaggg ggtccgggca gggggcggga
    14041 cggggtggcc ggcggcgcgc agcagggcga gcacgacggc gggcaggccg tcgccggcgc
    14101 cgagctggtg ctcctcggcc gccgtccggt cgggcaggca ggagccgtgg gcggcgcggg
    14161 ccgcgaactc ccacccgatc tcccgcaggg tccgccgcgc cgcgccgcgc tccccggcgg
    14221 cgccgccggg ggaggccgcg gcggccgccg cgcgctcgcc cgccgccagg agggcgtcgc
    14281 tgccgagcgc gcagtaccgc ccgggcgccg cgccgggctc gccgggcgcg gcctgggccc
    14341 gtccggagcc gcggcggtcc cgcgcggccc gcgcgcgggc cagttcctcg gcggcgtggc
    14401 gcagtgccgc gggcgcggcg ccgtccgtgg cgagcaccgt gatgcccagc gcgggttcgt
    14461 gccgcagccc catccagtgc gagccgccgc cgctgtccgg gatcgcggcc cggtgcgcgc
    14521 ggtccagcag gtgcccggcc agccgcagca ggtcgtcgtc gtccgctccg acgggcgggt
    14581 gcgcggggtg cggcgggacg gggcggcggt ggccggtgtg gacgtcgacc aggtgctggc
    14641 aggtccgcag gacggcgtcg ccgaccgggt ccggcccctg gcgggccctc agcagccggg
    14701 agcgcagcgc ggccccgccg ccgggcgcca gcaggcccgg cacccgtcgg ccggtcgagg
    14761 tcaggatgtc ggtgccgccc accacggtgc ggaagatcgg cacgtccagg cggcgcaggt
    14821 cggcgaccga ggccgcggcc agggcgatcc ggccggccgt cgccggcgtg gcggggtcgg
    14881 cgccgtgcgc cagttcggcc cgcaggacgc gggccaggac ggcctcgcgc cgctcgaagc
    14941 cggtcagcgc ctggggcgcc tccgccgcgc gcatcgtggt gaacgacgcc caggtgctgg
    15001 accacatcac gcggaccgtg gtgccgtcga aggcgtggcc cgcgccgccg ggcgcggtca
    15061 gccgttccgc cgaccgggcg agcgcggtgt ccgcctcccg gtagccggcg gcgaccgcgg
    15121 cggtgtgctc gcgcgggtcg agcacctggt cgccgtacca ggccatgctc tccggctgcc
    15181 aggtcagcgc gccgtcgagc aggcccaggt cccggccgtg ctcgctcagc cgcggcacct
    15241 ccggccggaa ggggaccggt ttgcggtcgg cggggctgca ccctcccacg tccaccgcgg
    15301 ggccgccggg gcgcagcagc accggggcgg tcaccatgcc cgtgggcagc gcggtgtccg
    15361 ccagcgcggc ctccaccggg tcgtccgtgc ccgtggcgaa cacggggtgc atgaccgtct
    15421 ccaggtccag gacgaccggc agggcgccgc aggggcgcag gttgtcctgc cacaggtcgc
    15481 gtgcctgcac cagggtggcc agccggatca ggcggcccag gtgccgcggg tagtccgcca
    15541 gttcgtccgg cgccgagcac gcgccgcgct ccacgtagcc ctcccaggcg tagccgtcgc
    15601 gggccaggag ggggcggcgg tgcggggggc ggtcggggaa cgcgtcggcg gtctcgtcca
    15661 gcaaccgcag gaaggcggcg gcgcagctca ggtcgcgggg cttgtagacg gcgcgccggc
    15721 cgcaggcgaa ggtgagcacc gcgacgttcc gaccgtcgtc gtgcggatcg ccggcgtcgg
    15781 ccgcgacccg gtccagggcg gcggcgcgga cctgtccgaa caggccctcg gcaaggacgt
    15841 cccggtccgc ggcgagccgg gtgagcatct cccgggtggc ggcccgccac tgccgcaccg
    15901 cggtgccgac caggaagccg aggaccggca gcgccgccag ccgccggcac cagtcgccgc
    15961 gcgagccgtc gatctcggcg ggccgcagga agcgcaggtc gaagtcgagg gccggcccgc
    16021 agtgcgcgag gacgcggtcc gcgccctgcg cggccaggtc cgcttcggca cgttcggtga
    16081 gttccggcgc gcggccggcc gcccgcaggg cggcgaggtc ggcgagcagc aggatgcggg
    16141 tggcctcccg catgcaccgc tgcggcgccc acagcccgtc gtcgccggtc gaacggtccg
    16201 gcagggcgcg cagcaggagg gcgagttccc gggcccaggc cggcagggcg gtcagccgtg
    16261 cggggtcgat ccccgcgtgc gccgcgagga cgtctccggc gccgagcgcc ccggccgcca
    16321 ccgcggcgcg caccgcgggg gcgtccaggt cggaggtccc cgtggccgcc gcggcccact
    16381 gcgcggcccg acggcgcgcg gcgtcgtcga ggaccgcggc cgggccggcg gcggcgcggt
    16441 cggccggcgg ggcgccggcc gcgatcaccg tcgccaggac gtcggccagg tcgccgaggc
    16501 cgcgcagcac cggaccggct ccgggtgccg tgacggcacg ggcgaccggt ggggacggga
    16561 aggcggcacc cgacggggac gggaaggcgg cgccggacgg ggacggggcg gcggctccgg
    16621 acggggacgg ggcggcggct ccgggcgggg aggggaggct gctcatcgcg cgccctcccg
    16681 tccggtcgcc gcgcccaccg gatccagcag gcgggcgaac gccgggcagc cggtgaccag
    16741 ttccgcatag cggcccaccg cgaccggcag gccgtcctcc agcacgagga tgcggtcggc
    16801 cgcggcgagc gactcgaccc ggtgggtgac cacgatccgg cccggtccgg cctcggccag
    16861 ccggccgagc agcgcgacct cggtggccgg gtcgaggccg ctggtggctt cgtccaggac
    16921 cagcaggcgc ggccggccgg ccagcgcccg ggccaccagc agccgctggc gctgcccccc
    16981 ggagaccatc cggttgcccg cgcccaccgg cgtggccagg cccagcggca tggcccgcac
    17041 ctcgtcggtc agtccgacgc cgtcgagggc cgcccacacc gcggcgtcgt cgatgccggg
    17101 ccgcccggcg gcgacggtgc tgcggatgtc ggtcccggtg gcggtggcgt cctggagcac
    17161 cgcggccagc gagcgccgtg ccgagaccgg atcgaggccg tcgagccggc ggccgtcgaa
    17221 gcgcacctcg ccctccgcca gggggaccag gccgagcagg gcctggacca gcgtggactt
    17281 cccggcgccg gaggctccga ccacgccgac gaactcgccc ggtccgacgt ccaggtccac
    17341 gccccgcagc agggccgcgc cgcccggggc gcgtacgccc accccgcgca gtgccagccg
    17401 gcgggcgggg ggcacggcgg cgccggcggg ctccgcctcc agccccacca cctccagcag
    17461 ccggtccacg acggggacca cgccgaagac ggcggtggcg atccgcccgg cctggccgac
    17521 ggagccgatg aactgcgtca gggcgatgtt gagggccagc aggccgccgg cgcccgggta
    17581 cgcggtcccc agcagcagcg gcgcccccag cagcagggcg tagagcaggc ccggaagggc
    17641 cgccgtgagc ccgctggcgg cggactgcca gcccaccgcc gccaggtcct gccgcttctg
    17701 ctccgcgaac acctccagcc agcggccgaa ggcgcgttcc tcccgcccgg ccacccggat
    17761 cttgtccagc ccgcgcagca tttccaggag cgtcgacgac gcctccccgt agagcgcgaa
    17821 cacccggcgg tcatggcgga gttggcgcat gccgaaccag ccggagaggg cggcggcggc
    17881 gagtaccagg gcgagggcgg gcaggctcgg cagcggcgcc agcacgatga cgacgacgag
    17941 gctcgcggcg ccgaacagca ggttcaggag ggccgacaag gtggtgttgc ccagcatctg
    18001 gcgcaccgcg tcgactccgg cgacccgcac ggcgaggtcg ccggcggtgt actcgcgcag
    18061 ccgccaagcc cgcgtccgca gcagccggtc cagggcggcg ggcccgagga ccgcctcggc
    18121 gtaggactcc agccgggcca gcaccaggtt ccgcagccag accaggccgg cgtagacgcc
    18181 cagtccgaag ccggccagga ccgccagctc gccgaggagt ccggtacggt ccccgagcac
    18241 cgcggacagg gcgagggcgc ccgccgacgg caggaacgcg ccgagcaccg cggcggccag
    18301 gccggcggcc agcagcaggg ccaggtcccc gcgcctgcgc ccgtgggccg ccaggtcccg
    18361 ggcccggcgc gcctccagcg gccgtgtcac ctcccacgcc cacggcgtca ggtcggcggc
    18421 ggtggccgcg tccacccgcc cgatcgcgcc gtggcccggc aggaccagcc ggaaggagcg
    18481 cccgcggggc aggagcgcga cgggcgagcc gtcccgccag tagccgagga gggggtgcag
    18541 cggggtgcgg tgccagtcgt cggcgagcgt caccacgcgg gctcgcagcc cgagcgcctc
    18601 gaaggcgccc tggacgtccg ccgggccctc ctcgtcccgt gtcccggacc ggtccgccgc
    18661 gggggcggcg ccgaggtggg ccgccacctc ctcgacgcag ccgcggggcg gggcggcgga
    18721 caccggggct ccggcccgga accggtccag cggggagagg ggcgaagccg cggcgctcac
    18781 cggtcgccca ccctcgccgc tcgcgccccg gccagcgggc cggtggcgga ccggccggcg
    18841 ggcggcgttc cgccgggcgg acccgtaggg gccgggccgg acggcgtcac acggccttcg
    18901 cgcacgacca gttcgcggtc gcacgcccgc accgccgagc gccggtgggc cagcatcacg
    18961 accgtcacgc cgcgccgccg cagccgggcg aagagctgct gctccacggc ccggtccagc
    19021 gcgcccgtcg cctcgtcgag gaccaggagc gacgggtcgc aggcgagcgc ccgggcgatc
    19081 tccaggcgct gccgctcacc gccgctgaag ttggcgccgc cctcgtcgac caccgcccgg
    19141 tggcagccgc cccggagttc gaccacacgg tccaggcagg cgtcgtggac ggcccgttcg
    19201 atcgcctcgt cgctcaccgt ctcgtcccac agcgccacgt tctccgccac cgttcccgcg
    19261 aacagctcga tggtctggtc cacccaggcg acgctccgca ccagctcgcc cctgggcctc
    19321 tcgtccgacg gccggccgtc gagcagcacc cggccggtca gcggggccag cacccccgcc
    19381 gccagccgcg ccagcgtggt cttgccggca ccggtcggcc cggtgatcgc cacccactcc
    19441 cccgccgcca cgtcgaggtc cacctcgcgc agcaccggcc ggcccggggc gtacccggcc
    19501 gtcacctgct ccatccgcaa cgagcccccg gcgcgcgcac cggtgtccgg ctccacggtc
    19561 cgcaccgcgg acgggtcgta cggctcggcg aggaggtcgt ccagcagccc gatgcgggtg
    19621 agcagtccgg gcaccgcgag gagcccgccg accgccgtag cggccgccgc cgtgaacccg
    19681 cccgtcaggc tctgcaccgc gaagagcgcg ccgagggtca tgtgcaggtg gaggatgcgc
    19741 ggcgccgcgg ccaggacgac cagcgacgag gcgcccacgg tcagcaccgc cggcagggcg
    19801 gtgagcgtct gctgctgccg gttgtgcacc gacgtggcgc gcaccgcgac cgcgtgcagg
    19861 ctgctccacc gaccggtcac ctcggcctcg ccgccgcccg ccttgaccgc gtccagcgcc
    19921 ctcagcgccg cgaagcccgc cgcgtcccgg caggcggtca gccgggcctc caccagcgcg
    19981 gcggcggact ggcgccgcca gctggtcagc ggcaccccga ccaccagcag gccgagtccg
    20041 accgcgaggc cgccgaccac ggagtcctcg cgcacgatca ccgtgccgag cagggcggcg
    20101 ttgaccaccg cgcccgccgc cggcaccagt tggtgcacga ggcccaggct gaacgcgtcg
    20161 acggcctgcg cccgggccgc catcgcaccc gggtcgcgcc gcagcagggt ccgtccgtcg
    20221 atgtgcagca gccgccacac caggtccacc gacatcgtca gggactggcg cacctggaga
    20281 cggcccagga gctggttctg cgcggccacc gccagcccgg acaccaggcc cacggccacc
    20341 gtgaccgcgt agagccgcag cccgccgccg gaccctcccg acaccgcgtc cgcggccagg
    20401 agcttcaaca ccatcgccag cagcagggac atggccccgc ccaccaggga cagcgcgacg
    20461 gcgcacagga cgcccggcca ctgggcggcc agcgccgccg ccagccgccg gcccgcggtg
    20521 ccgcgcggcc cgccccgggt gaactccgcg cccggctgcg ccgtcagcag caccccgctc
    20581 agttccggtg ccagttcggc gaacggcatc cggtgccggc cgatcgcggg gtccacgacg
    20641 gtcaccaggt cgccgcgcac ccgctcgacc acgacgaagt ggccgtccgc gagatgcgcc
    20701 accaccggca gcgccaccgt agcgaggccg gaagggtcgg ggacgccgtc gcgccacggg
    20761 acggtgatcc gtaccgccga ggctcgaaga ccctggtccc gggccgcgcg cagccaggtc
    20821 agcgcgtcga cgccgtcccg ggacgcgccg gtggcctcgc gcaggtcgcg cagcggcacg
    20881 cgccggccgt ggcaggccag cacggacgcg aggcaggcgg gcgcgcagtc ggtctcctcg
    20941 gcctgcggca cgtaggggac gcggagggtg cggctcacca gtgccctccc gtcagctcgt
    21001 ccagggggtg caccgatccc gtccggaccc gcgcgatcac cggtaccagc gccgggagtt
    21061 gggacgccac gtcgccgctc cccagcccga tccgcgccgc gccggcgacc agcgcgtcgt
    21121 ggaggtccac cgtcaccagg cgatacgggc cgtgcccgct caccgcgagg gaggcggaca
    21181 gcccgcccag catccggctg acctccgcgg cggtgaccgg gtagcgcccc accgagccga
    21241 cctcgccgct caccgagacc gccgactggt cggaggacaa ctgggcgctg accgccgccc
    21301 cttcggtcac cgggaagccg cggtcgctgc cgaggaacat ccaggcgcgc aggccccccg
    21361 agccgctatc cacggacacc accggcgtgc ccggggagac cgccgtgccc ggagccgaga
    21421 cgatgcccag cacgctgccg tcgacgggtg cgaggaccgc acgggtgccg cctcccgcga
    21481 cggcgacctg tccgacccgc tggccggagc gcaccgcgtc gccgggcgcg acgtccacgc
    21541 tcagtacggt tccggtgacc ggggaggcca ccggcctcgg gccgctgccg tgcaccagca
    21601 cgccctccag ccggacggtc gactgcaccg tgccgatcgc cgcccaggac accaggcccg
    21661 cgaccgccgc gagcaccacg gccagcgcgg tcagcaggcc cgggggcacc agggtcatcc
    21721 gctggccggc gatgcgcgcc gccgacgcca gccgctcctg cgcccgcgcc tcggcggcgg
    21781 cttcctgccc ggcgatggct tcctgctcgg cggtggcctt ctcctcggcg gcggtttcct
    21841 gcccgcccgg cgctccggtc ccggccgtgc cgtccgcctc gaccccgtgc tccgcctcgg
    21901 ctgcggccac ccgtcccgtc cgggccgcgc cccgcgcgtc gtccgccgtt cccctgccgt
    21961 gctcggacat cactcgcccc ccgcgggacg gttcgcgccg tcgtgggcgc tctcccggcc
    22021 gcccggcgcg ggcgtcgggt ccggctccgg ctccggctcc ggcgggagct cgcgcaccgg
    22081 cagacgggac cagccctgga ccgccggcga ccggtgcggc acggcacccg gcagaagggc
    22141 gagccttccc ggccgcccgg ccaggaaccg caggaactcc gcgcccgcga ggtcggcgtg
    22201 gtgcatgccc aggcagatgt gggggccgtg cccgtaggcg agggcggcct ccgggcccgt
    22261 gcgggggccg gggccggcgt cctcgccggc gagcgcggag gccagcagca gcaccaccgt
    22321 ctgccccgcc gggagggcga ggccgccgac cgacgcgggg caggccgccc gccgggccag
    22381 catcctcagc gggctcgcgg cccgcagggt ggaacggaag gcgtcgtgcg cccggtccgg
    22441 ctcctcgcgc agccgggcca gcagctccgg ctcggctgcg gcccggtgcg ccgcctgggc
    22501 caacgcctgg ctgagggtct ccagccccgc cgtgagcagg agtacgaaga gcgcaaaacc
    22561 ctctgcctcg tcggcggtcc ccgtccgcac ggcctcgccg accgcgtaca gcggcccgcc
    22621 gtccgcggcc gccagggcac ccctcacgta ccgccgcagc gcggcgagtt cgccggcgag
    22681 ggcgtccgct tcctcccccg aagggccggc tccgggaccg atacggtcgc gcagcagccg
    22741 cgcccagcgc tccagttcgt cggcgtcccc ggcgggcagt cccatgacca ggagcgccag
    22801 tcgcaccggc aggcggtccg cgtagccgct gacgaagtcg aagccctcgc cggcgtccgc
    22861 cggccacgtc cgctcgaccg cctcggcgat ggcggcgcgc gccgccgacg cccggcgccg
    22921 ggtgaagtac ggcgcgacca ggcggcgcag ccgggcgtgt gccgacccgt cgcgcaggct
    22981 gggcatggcc cggaacaccg cgtcgaggtc gtcgtgcggg ctgatccgca gcgcgggcag
    23041 cctgccgtcg ccgtccccga cgaccaggcg tggatcgccc agcgcctcgc gcgcggcgtc
    23101 ggcccgtgcc accaccgtca gcccggtgcc cgcgtggagg gcgggccagc ggcgggcgac
    23161 ggacggactg agcgtcggac gccggccggc caggcacgcc aggacctcgc cgaccgccgc
    23221 ggaggtcggg ttcgcggtct cccccatggg ctgttcacgc tcttccgtca gtgccggcgg
    23281 gcagggttcg ccctgcccgc cggcggcgaa tcaccggcgg ggccggagga tcacgacacg
    23341 ggcagggtgg gctgcgagcc gcagcaggtg ccggacccga cggtgctcgc ggtgcagccg
    23401 ggacaggaga acgagctggc cgagccgcag gtgctcaggc cgccgacggc ccccagcagc
    23461 ccgagggact cgtcgctgat ctcctcgacc ggagcgggcg gcaccggcag tgcctcctgc
    23521 gcgctgatcc cgtactcggc gagcaccgcg accggctcgt cccggtagcg cgtcgcgagt
    23581 tcctcgtcgc tccagagctg tgccacgaga gcaccgaaac tgcgtctttc ctcggcggtc
    23641 agctggatgt cggacatcga cacgtccaat ctcggatcgg ggtcccgggc cacacggccc
    23701 ggggaccagg caggtggctt ccaccgatcg gggcccgacg gccccgtacc gtgcggaacg
    23761 cgaagcggaa tccccgtatc cgggtccgcc gagacggaaa tgtggcacag cgcgtccctg
    23821 cccgacatcg gggaaacccc tacgcgcgac cccaacaccg cttccggcgt gcggggttgg
    23881 ccctccttct cggcacggca gcggccgtcg tccccccgaa agggggtgcg ggaacggcgc
    23941 gcgtgtgacg gacgggaggc aggtgacgga atggagtca
//
