LOCUS       NZ_AP018365            22652 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  Streptomyces sp. SN-593 chromosome.
ACCESSION   NZ_AP018365
VERSION     NZ_AP018365.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. SN-593
  ORGANISM  Streptomyces sp. SN-593
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Panthee,S., Kito,N., Hayashi,T., Shimizu,T., Ishikawa,J.,
            Hamamoto,H., Osada,H. and Takahashi,S.
  TITLE     beta-carboline chemical signals induce reveromycin production
            through a LuxR family regulator in Streptomyces sp. SN-593
  JOURNAL   Sci Rep 10 (1), 10230 (2020)
   PUBMED   32576869
  REMARK    DOI:10.1038/s41598-020-66974-y Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Takahashi,S., Toyoda,A., Sekiyama,Y., Takagi,H., Nogawa,T.,
            Uramoto,M., Suzuki,R., Koshino,H., Kumano,T., Panthee,S., Dairi,T.,
            Ishikawa,J., Ikeda,H., Sakaki,Y. and Osada,H.
  TITLE     Reveromycin A biosynthesis uses RevG and RevJ for stereospecific
            spiroacetal formation
  JOURNAL   Nat Chem Biol 7 (7), 461-468 (2011)
   PUBMED   21642985
  REMARK    Publication Status: Online-Only
REFERENCE   3
  AUTHORS   Panthee,S., Takahashi,S., Takagi,H., Nogawa,T., Oowada,E.,
            Uramoto,M. and Osada,H.
  TITLE     Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds
            from Streptomyces reveromyceticus SN-593
  JOURNAL   J. Antibiot. 64, 509-513 (2011)
REFERENCE   4
  AUTHORS   Takahashi,S., Takagi,H., Toyoda,A., Uramoto,M., Nogawa,T., Ueki,M.,
            Sakaki,Y. and Osada,H.
  TITLE     Biochemical characterization of a novel indole prenyltransferase
            from Streptomyces sp. SN-593
  JOURNAL   J Bacteriol 192 (11), 2839-2851 (2010)
   PUBMED   20348259
REFERENCE   5  (bases 1 to 8833490)
  AUTHORS   Takahashi,S., Ueki,M., Toyoda,A., Ishikawa,J., Sakaki,Y. and
            Osada,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2017) Contact:Shunji Takahashi Chemical Biology
            Research Group, RIKEN Center for Sustainable Resource Science
            (CSRS); Hirosawa 2-1, Wako, Saitama 351-0198, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Phrap v. 0.990329
            Genome Coverage                   :: 16x
            Sequencing Technology             :: ABI 3730
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016756395.1-RS_2024_05_21
            Annotation Date                   :: 05/21/2024 03:58:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,420
            CDSs (total)                      :: 7,334
            Genes (coding)                    :: 7,181
            CDSs (with protein)               :: 7,181
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 153
            CDSs (without protein)            :: 153
            Pseudo Genes (ambiguous residues) :: 0 of 153
            Pseudo Genes (frameshifted)       :: 35 of 153
            Pseudo Genes (incomplete)         :: 136 of 153
            Pseudo Genes (internal stop)      :: 8 of 153
            Pseudo Genes (multiple problems)  :: 25 of 153
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:29:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 726608
            Orig. end                         :: 749260
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP018365.1.
            This work was done in collaboration with Shunji Takahashi, Masashi
            Ueki, Atsushi Toyoda, Yoshiyuki Sakaki and Hiroyuki Osada (RIKEN)
            and Jun Ishikawa (National Institute of Infectious Diseases).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22652
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="5"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22652
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22652
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12652](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12652
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(847..4677)
                     /locus_tag="RVR_RS37300"
                     /old_locus_tag="RVR_859"
     CDS             complement(847..4677)
                     /GO_process="GO:0009190 - cyclic nucleotide biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0035556 - intracellular signal transduction
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508342.1"
                     /locus_tag="RVR_RS37300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_859"
                     /product="adenylate/guanylate cyclase domain-containing
                     protein"
                     /protein_id="WP_237404539.1"
                     /transl_table=11
                     /translation="MRCAACDAELPSEARFCPSCGTPAASKPAGVPQEERKVVTVVFCD
                     LVGSTALSGVLDPETLRTVVLRYFDRMRECLEEFGGTVEKFIGDAVMAVFGVPVTHEDD
                     AARALAAGLAMLEAVQRLNDTELGPSLGIRIGVRIGINTGPVVTASDVSSRQALVSGET
                     VNVAARLEQNAGEGEVLIGPESLRAAGARALTEPVGPLLLKGKEDAVSAYRLLAVVEEE
                     PEVTRRFDVPFVGRDRQLDALREALAAAAERDGRGPNLVTVFGEAGMGKTRLIHEWRKQ
                     SGGAFAYGSGRCRPYGERGSLAPLAEAVRQLLDEFPEIRLLPDARGGDGPDGPGGPAAG
                     AGGHGDGDTRGAGAAAEDAAEGDEVGAALAVLSAGLLEDGTPNPSTDDTCAALTGLLAV
                     LARRRPVVLVLDDLHWASDPLLAMVTALRAELASAGVLFVCAARPDLADRHAGWGGPGA
                     RALTLPGLTTPQAEAVAEALTEVGAHWDGAASPDRSGPRAARPRRRTGVPPQVLESAGG
                     NPFYLEQLIAALTQPDSGYRPDGGGDLPTTLQALLGARIGALGRAERAALDIAAVAGRE
                     FTADEVADLVAGDPEGAPGGALHDGTRPEAGGPAPRPPLNGPVGAALARLGRHRLLSPA
                     DRPRPGTYPLRFSSGLVHEVTYQSMAKRTRAERHEHAALALSERLAAATRPANAAAPGG
                     GSGAAGGPAGAGDGPAGRNAVSGGGSGSPAGAVNASASGGSPSAATGQASRLSEVLAEP
                     GAVVGGAPGSPVAAAGGALSGGPSTAAAMAAYAVAGPAAVAGAAPLAGTPGRADPAPGA
                     ARVAPPSGSAGRGASAEGLAAVAAHLERAYRYRAELGVLGPHTEELRLRAVRLLIDAGS
                     RALARSDLAWAAGLLERAVELAAEGEPEWAAAARRLGDVLLATGRTDEGRALLLQVLDA
                     ADAGPRDAVRPVEAAHARLALAAVSAAPDGSSAGTVAQWALPVFEGAGDDLGQARACIR
                     IAQDRQSHGSHVAADDLLSRALAHARRAGAEPERALALGAIGISLWRGPEPVSSAVARS
                     RALLAEHGEQRPTVRLTLNCPLAVLLALQERWEEADACLARSRRLAGELGYAEGRVVLP
                     LFAATVAALADDRDRALHLLDEADGAAAGLQAGGLRGVVARESARLLLDAGRVEDAVAR
                     LTEVPGGATAGAGEAASDTADLDGLLARIAAARGNAEEAETLAARAVHTASGTDSPVLI
                     AVAWLDRADVLRRSGRAEDARQAAAQAARQFAAKGHLPGARQAARWQQEPA"
     gene            complement(4711..4971)
                     /locus_tag="RVR_RS03100"
                     /old_locus_tag="RVR_861"
     CDS             complement(4711..4971)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577231.1"
                     /locus_tag="RVR_RS03100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_861"
                     /product="aroma-sacti cluster domain-containing protein"
                     /protein_id="WP_237404540.1"
                     /transl_table=11
                     /translation="MTDGAAQGRDDGGTGRSGEGGRPADDTLDVLRAHGFGVAELTEEQ
                     QEVLRGLSAEELSVMLDIKARLDEVGPEVQAHSEIAGGALF"
     gene            complement(4968..5675)
                     /locus_tag="RVR_RS03105"
                     /old_locus_tag="RVR_862"
     CDS             complement(4968..5675)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511307.1"
                     /locus_tag="RVR_RS03105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_862"
                     /product="iron-containing redox enzyme family protein"
                     /protein_id="WP_237404541.1"
                     /transl_table=11
                     /translation="MTAGTAVPAGTALSARLLLTAPAVRAATTAMWRAPGLARRYGRYL
                     EDMHGLIRASVPLMQRAASRCADLGDAVGAPLAAYLRVHVEEERGHDDWLLDDIAALGG
                     DPAAVRDRQPSPAVARLAGAQYYWIEHHHPVALLGYIAVLESNAPAPWLADEIAAAGVP
                     EAALRTVRGHAELDTGHTAELFALLDGLPLDPPLVNAVVMSALHTVDGLVELFAHIGRA
                     AQQDHSRERTHTS"
     gene            complement(5672..6781)
                     /locus_tag="RVR_RS03110"
                     /old_locus_tag="RVR_864"
     CDS             complement(5672..6781)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608637.1"
                     /locus_tag="RVR_RS03110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_864"
                     /product="radical SAM protein"
                     /protein_id="WP_202232361.1"
                     /transl_table=11
                     /translation="MELAELMTQRPLPGAGLLLTVTGRCPLHCAHCSTSATMASGEPDA
                     ARLRSFVGTFTPAAHPSVLMMTGGEPLLRPELVTELAATARAAGTRTALLTGAFFAGRA
                     DRPGHPGQVAAVPERIWRAVTAVDHFSVSVDAYHERETGRAPVFALVRRVLDAGVAASF
                     HLVGSGADDPYLADVTADIRRTFGSRVPMLVNSLRRVGRAASWAAADTASPDPERALPC
                     SMAAWPVVAADGTVVACCNQAVVDRRPAPAHLTLGHIGTDDWESISARAVRSPVLRMIR
                     TVGPAHLRHRYGAADEAAPRPGYCDGCRALAERPEVLAAATAAGAGPVGALLDRYAARG
                     QAEAGAVALVRRHGCAPYADLVALHGAAR"
     gene            complement(7316..9232)
                     /locus_tag="RVR_RS03115"
                     /old_locus_tag="RVR_866"
     CDS             complement(7316..9232)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608633.1"
                     /locus_tag="RVR_RS03115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_866"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_202232363.1"
                     /transl_table=11
                     /translation="MAEPLHDSLRLTVLGPLSVGTAEGPFPLGPLKQRLLLAMLLLRAN
                     TPVSLDLLTDTLWDGRPPRTARKNIQVYISALRKLLDRAGAGERLAHHAGGYLMRVRDD
                     ELDVLRFRHLARGAREATAQGALGPASRMLREALGLWQELPLRELRFSPAVRSEAERLD
                     SRYVQVYEDWAEVELRLGRATEVAETVGDLVERHPERERLRAVQMTALFDQGRQTEALA
                     AYAALRQLLAAEYGLQPSAALETLYRSILDGGPQQPGSSLGPLGAAGPRAAARRPGGVL
                     GTVLPQDLADFTGRERHLRDLTGLLAGERRLTLLTGPVGTGKTALAVHAAHRLAAEFPD
                     GRVLLRMRDEDGRPRTAASLVAELARMADLPEPARTADLPGAAPGAGVRRAGAQEAGTE
                     EAAAAWRTWLEPRRVLLVLDDAADEGSVRPLVPDTGGSAVLVTSRAQLAGLASANRLDL
                     AAFDRSESLELLGRIVGHDRLRSCPASAEQIVAATGMLPLAVRVSGLKLAVRRYLPLGE
                     YAARLADGRTVLDELVAGDTDVRPRLDSGWNDLPTADRTTLCLLAELPEGPFTLRQAAE
                     ALTCDQDRALHKLESLMDAGALIAPDCEVTAHAAHYELPRLTQVYAREQALQHVQPLPR
                     ATA"
     misc_feature    complement(9308..9321)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.73"
                     /tool="antismash"
     misc_feature    9371..9386
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     gene            9497..9649
                     /locus_tag="RVR_RS03120"
                     /old_locus_tag="RVR_868"
     CDS             9497..9649
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608636.1"
                     /locus_tag="RVR_RS03120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_868"
                     /product="hypothetical protein"
                     /protein_id="WP_202232369.1"
                     /transl_table=11
                     /translation="MADAVDPTNEDTTAETENEVEAHSEALDLQEMGVSGLEAPGSTVS
                     LAACA"
     CDS_motif       9497..9610
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MADAVDPTNEDTTAETENEVEAHSEALDLQEMGVSGLE"
                     /locus_tag="RVR_RS03120_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9611..9649
                     /prepeptide="core"
                     /locus_tag="RVR_RS03120_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="2.10"
                     /molecular_weight="993.1"
                     /monoisotopic_mass="992.5"
                     /core_sequence="APGSTVSLAACA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MADAVDPTNEDTTAETENEVEAHSEALDLQEMGVSGLE"
                     /leader_location="[9496:9610](+)"
                     /alternative_weights="1011.1"
                     /alternative_weights="1029.2"
     gene            9757..9954
                     /locus_tag="RVR_RS03125"
                     /old_locus_tag="RVR_869"
     CDS             9757..9954
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS03125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_869"
                     /product="hypothetical protein"
                     /protein_id="WP_202232370.1"
                     /transl_table=11
                     /translation="MADPVDPASSAVPDDEQTAPEAADGESEVEAHVANPLDLQEMGVQ
                     TSFADNVIGSTSATSLISCC"
     CDS_motif       9757..9912
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MADPVDPASSAVPDDEQTAPEAADGESEVEAHVANPLDLQEMGVQTSFADNV"
                     /locus_tag="RVR_RS03125_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9913..9954
                     /prepeptide="core"
                     /locus_tag="RVR_RS03125_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="3.70"
                     /molecular_weight="1134.3"
                     /monoisotopic_mass="1133.6"
                     /core_sequence="IGSTSATSLISCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MADPVDPASSAVPDDEQTAPEAADGESEVEAHVANPLDLQE
                     MGVQTSFADNV"
                     /leader_location="[9756:9912](+)"
                     /alternative_weights="1152.3"
                     /alternative_weights="1170.3"
                     /alternative_weights="1188.4"
                     /alternative_weights="1206.4"
     gene            10001..12652
                     /gene="lanKC"
                     /locus_tag="RVR_RS03130"
                     /old_locus_tag="RVR_872"
     CDS             10001..12652
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="RVR_RS03130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_872"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_202232371.1"
                     /sec_met_domain="micKC (E-value: 9.6e-143, bitscore: 475.7,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.9e-09, bitscore: 35.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 0.00073, bitscore:
                     17.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPFLYVVADKEFYAPLETARDRGEVYRPAGVPDGWAGTESGIWT
                     MWHRGRQLRGVEDGWKVHVSARPGRQQHVLDTVAAVCFEQDVAFKHMSCSLAYWWMHHK
                     QAARQQSGKFVAAYPTDVEAARALMERLRTELDGEQGPFVLTDRRYRDSRTVHYRYGAY
                     LPRDRVNADGTYTMLLRRPDGVVEEDHRGVSFHLPEGVVDPFVKRRPAAAGTKAAAPRR
                     KAGTPRTEPVTFHGYTFEEALQFSNAGGTYRARELATGRQVFIKEARAHTGVAHGERTA
                     PDQLRSEHHTLTALHAAAPGLAPQPLELFHEWEHDYLVTEFIEGETLQRWMVAHQPMLG
                     TGRLPHEFDDYYARCEKLLERVESALERLHAAGYLFVDVSPGNVMVGEDDSVRLVDFEA
                     AQRADADEILVMGTPGYSPPPELVGDDRRIHDDFGLAGLALLLLGPFHQSARRNPDALA
                     HLRGELLERAPLPEPLWQKAVRFHPPRAAADGALPLPSPEEVAADPLRHLADLRDRTAD
                     ALVAMAEPDHPDRVFPTIADGYRTNTQCLAYGSAGVLHALTRAGRALPDGALERLRTDA
                     FDRIDRLGPGLMAGTAGIAWVLADHGLLDEARDLLAAADRHPLITSGASATLFGGSSGL
                     ALAHLAVYGHTRDAAHVERAAELAAALPSDAGLAPLLGADDATGLMHGRTGIALMLQQL
                     AAVTGSDDGLERGVRLLHAELDRATDPDAPGLAFPISATDSRSLPYLYSGSASMAHAVV
                     RYTRTVDDERLAQALPRLLASTRTTYTAMSGLFQGLAGLGFALAEQARLTGERSARADA
                     VRGARGLFKFAVPHPTGVRFLGDQLMRFSADLWSGSAGILLFLTQLLDPAPDPLFTVDA
                     LSGAHARTPAAR"
     gene            12660..14003
                     /locus_tag="RVR_RS03135"
                     /old_locus_tag="RVR_875"
     CDS             12660..14003
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="RVR_RS03135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_875"
                     /product="MFS transporter"
                     /protein_id="WP_202232372.1"
                     /transl_table=11
                     /translation="MSVEKTDGTNGSPTGDAPAADPPDGASAGWAATRDVNLYWCGQTA
                     SAFGSVFTTIALPVVAVVHLNASAGAIGLISAAATAPILLLGFPAGALADRLAHPRRAL
                     ILLDLICAAAVGVVALGLAAGAVSLLWLGLLCAIMGATSTLSMSVYFLHLRQLVGPDGI
                     GGARARLQAGQYGAALVGRLLAGPAIALLGAAAALSVDVASYLLSAAALVTMRSTDLVP
                     RGPAPSVLTSLRGAMAGLRLFTGDGFHRALGVFIVVPAAALAGVTALTGPFLLRVIHLP
                     TAAYGSLFALSGLMGLSGSAVAGRVLAPGRDARRVLLGGFTAAMICSLLLPLSGGPLPL
                     AAFCAAMGIGLPIFFGAIANVAVSSVLVASMSEETLGRAMAALQVCVATAGLVGALGSG
                     VLGDWLGVRGALWAMGLLALGGIVLSLPPALRAARVAADVPEPEPAPV"
     gene            14285..14821
                     /locus_tag="RVR_RS03140"
                     /old_locus_tag="RVR_876"
     CDS             14285..14821
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014150717.1"
                     /locus_tag="RVR_RS03140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_876"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_202232373.1"
                     /transl_table=11
                     /translation="MDKRVSAVSSAAGRRAGTAAASPAGSGSAADEQSPAAPPPAPTST
                     LAGKIDALFRVVRRPNREPYSHEEVARACREATGESFSATYLWQLRTGRRDNPTKRHLE
                     ALAQFFDVPVGYFFDDEQGAAIAKELELLGALRDAGVRSMALRAVNLSPEDAATISDMI
                     DVLARRERGSAGRGL"
     gene            complement(15054..16274)
                     /gene="glgC"
                     /locus_tag="RVR_RS03145"
                     /old_locus_tag="RVR_877"
     CDS             complement(15054..16274)
                     /EC_number="2.7.7.27"
                     /GO_function="GO:0008878 - glucose-1-phosphate
                     adenylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0005978 - glycogen biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glgC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191734.1"
                     /locus_tag="RVR_RS03145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_877"
                     /product="glucose-1-phosphate adenylyltransferase"
                     /protein_id="WP_202232374.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.6e-09, bitscore:
                     36.3, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGGGPSVLGIVLAGGAGKRLMPLTADRAKPAVTFGGSYRLVDFV
                     LSNLVNGGILRICVLTQYKSHSLDRHVSTTWRMSNMLGNYVTPVPAQQRLGPRWYLGSA
                     DAILQSLNLIHDEQPDYVAVFGADHVYRMDPRQMLEQHAEHGAGVTVAGIKVPRADASG
                     FGVITPGADGVAVERFLEKPADPPGLPGDPGRVFASMGNYVFTTKALLEALHEDAEDPQ
                     SVHDMGGSILPRLTAQGAAHVYDFDANHVPGETARDHGYWRDVGTLDAYYDAHMDLVSD
                     RPAFSLYNRDWPIHTNPGSLPPAKIAAGGIVGESVISPGCVVRGQVTRSVLSPGVVVDT
                     GAVVQGSVLHHNVRVGRGAIVRGAVLDKNVDVPPGATIGVNPERDRALYTVSEAGVIAL
                     GKGAQVG"
     gene            complement(16581..17750)
                     /gene="glgA"
                     /locus_tag="RVR_RS03150"
                     /old_locus_tag="RVR_879"
     CDS             complement(16581..17750)
                     /EC_number="2.4.1.21"
                     /GO_function="GO:0004373 - glycogen (starch) synthase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="glgA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999075.1"
                     /locus_tag="RVR_RS03150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_879"
                     /product="glycogen synthase"
                     /protein_id="WP_202232375.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.4e-30,
                     bitscore: 104.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVALLTREYPPDVYGGAGVHVEFLARELRPLVDLDVHCWGEGNT
                     AGVFRHRAPAGLDGANDALRTFAVDLQMSAALGDRDLVHSHTWYANLAGHFGKLLHGIP
                     HVLTAHSLEPLRPWKAEQLGGGYALSSWAERTAMESADAVVAVSDGMRGDILSCYPGLD
                     PDRVHVVRNGIDTTTYRADPRTDALARLGIDPARPYVLFVGRITRQKGVPHLLRAARAI
                     DPAAQLVLCAGAPDTPALDREFRSLFDELSSVRDGVHWIPAMLPRPAVVQLLTHAAVFV
                     CPSVYEPLGIVNLEAMACGTAVVASAVGGIPEVVEDGETGLLVPYREGHAEEFEAGLTR
                     ALDRVLGDPAGAARMGEAGRLRAVREFGWDAVARRTADLYEAVAKAGTA"
     misc_feature    complement(18043..18057)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.83"
                     /tool="antismash"
     misc_feature    complement(18044..18057)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.01"
                     /tool="antismash"
     misc_feature    18166..18181
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            18231..18788
                     /locus_tag="RVR_RS03155"
                     /old_locus_tag="RVR_880"
     CDS             18231..18788
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014137214.1"
                     /locus_tag="RVR_RS03155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_880"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_202232376.1"
                     /transl_table=11
                     /translation="MTTPHPPAPLPLRAGERLALALAREEMMQDYHRWETDPATVVGFG
                     ARWPVSWEVFRARFLSSHTSRHYQLFEVVTTEGAVPVGTTSLNVDQAVNTAELTLVIAP
                     EHRGRGYAAEATALTLDWAFSIASLSAVWLEVLAPHTAAVNAYLKAGFRTAGRLRSAAL
                     WQGRRVDKLFLDCVPDDLAEKR"
     misc_feature    complement(18972..18987)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            19011..19976
                     /locus_tag="RVR_RS03160"
                     /old_locus_tag="RVR_882"
     CDS             19011..19976
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144521.1"
                     /locus_tag="RVR_RS03160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_882"
                     /product="acetylxylan esterase"
                     /protein_id="WP_202232377.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 6.6e-07, bitscore:
                     27.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQFDMPIEQLRTYRSESVEPPDFDRFWADTLAQARGHDLAARFE
                     PVATALRTVDTFDVEFSGFDGHRIKGWFTVPAGAREPLPVVVEFIGYGGGRGLPHERLT
                     WASAGYAHFLMDTRGQGGSWSTGDTPDPVGSGSATPGFLTRGITDRDEFYYRRVITDGV
                     RAVEAARTHPLADASRTVVTGVSQGGGLSIAVGGLVPDLVAVAPDVPFLCDLPRAVRIT
                     DAFPYREVASYLSTHRPERERAFGTLAYFDNVHFAARGRAPALFSTALLDATCPPSTVF
                     AAFNGYGHEDRTIEVYDFNGHEGGGAHHEALRLEWLPKYL"
     misc_feature    complement(20085..20100)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.32"
                     /tool="antismash"
     misc_feature    complement(20087..20096)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.37"
                     /tool="antismash"
     gene            20211..21062
                     /locus_tag="RVR_RS03165"
                     /old_locus_tag="RVR_883"
     CDS             20211..21062
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970969.1"
                     /locus_tag="RVR_RS03165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_883"
                     /product="SigB/SigF/SigG family RNA polymerase sigma
                     factor"
                     /protein_id="WP_237405217.1"
                     /transl_table=11
                     /translation="MRQAGSAHQEAPGGLPWIEDATAVAPQDARVLSKLFFDRLQELEE
                     GTHAYSYARNTLIEMNLALVHFAAGRYRNRPGTDREEIIQVGTIGLIKAIDRFDLSRET
                     EFTTFAIPYIVGEMKRFFRDTSWAVHVPRRLQELRVELSKAKEHLALLLDRDPTVPELA
                     AHLELTENEVLEGLVAANGYTAGSLDIPWSDSDAGPDSDGRTLADTIGDCDPTMELIEN
                     LGSLAPLVAELSDRDRDLLRMRFVEEMTQSQIGEVLGYSQMHVSRLLSRIVKKLRAGML
                     VQ"
ORIGIN
        1 acaggatgcg ggcgcacagc ccggcgatgt agggcgtggc gaagctgttg cccgtggtcc
       61 tgatcgtccc cccgccgagc cacgccacct ggacgttctg gccgggggcg aagaactcca
      121 ccggggggct cgggttgtac aggtgcagct cggggtcgtc ctcctggtgg ctgccgacgg
      181 agatcacgga cgcgaagcgc caggggaagc tctccaccgg cgtgttgtgc gcggaggcga
      241 cgatcgccgt gccgcggaag tacgcctcgt cggcgaggac ccgcagctcc tccgcgaact
      301 gcgggcgcgt ggtggacagg ctgaggttga tcacgtcgaa gccctgccgg atcgcccagc
      361 gcagcccggc cagcagcacg tccccggtgc cgccgaaccc cttgccgagc acctgcacgc
      421 tgtacagctc gcactccggc gcggtcctgc ggatgatgcc ggcgcaggcg gtgccgtggc
      481 cgcacgagtc ggtgggctcg gtctccacca cgctggtccc cgactcgtcc ttgcggaccg
      541 tccaggagcc gtcgacccgg ccgatcagcg ggtggtcgtc ctccaccccg gagtcgacca
      601 cgcacacccg caccccggtg ccgagcgcgt cggcccagcc ccggtcgggc gcgggcgcct
      661 cgccgtcggc ggcgaccagc acgtcctcgg ggtgcttgcc gcgcagactc caggtgagtc
      721 cgggccctgt gccctgctcg gcggttctca ttcagcagca gcctctcgcg ttctggcgtg
      781 gtcgcgtgtg cggtgcgggg gccggccgcg cgggccggcg gggtcggccg ggcggcggcg
      841 ggcggctcat gccggctcct gctgccaccg ggccgcctgg cgcgcgccgg gcaggtggcc
      901 cttggccgcg aactgccggg cggcctgggc ggcggcctgc cgggcgtcct cggcccggcc
      961 ggaccggcgc agcacgtcgg cgcggtccag ccaggcgacg gcgatcagca cgggcgagtc
     1021 ggtgccggag gcggtgtgca ccgcgcgggc ggccagcgtc tcggcctcct cggcgttgcc
     1081 gcgcgccgcg gcgatccggg cgaggaggcc gtcgaggtcg gcggtgtccg aggcggcctc
     1141 gccggcgccg gcggtcgcgc cgccgggcac ctcggtgagg cgggccaccg cgtcctccac
     1201 ccggccggcg tccagcagca gccgtgccga ctcccgggcg accacgccgc gcaggccgcc
     1261 ggcctggagg ccggcggcgg cgccgtcggc ctcgtcgagc aggtgcagcg cccggtcgcg
     1321 gtcgtccgcg agcgcggcca ccgtggcggc gaacagcggg agcaccacgc ggccctcggc
     1381 gtagcccagt tcgccggcca gccgccggga gcgggccagg cacgcgtcgg cctcctccca
     1441 ccgctcctgg agcgcgagca gcaccgccag cgggcagttc agggtcagcc gtacggtggg
     1501 gcgctgctcg ccgtgctcgg ccaggagggc gcggctgcgg gctaccgcgg aggacaccgg
     1561 ttcggggccg cgccacagcg agatcccgat cgcgccgagt gccagggccc gttccggctc
     1621 cgcgccggcc cggcgcgcgt gcgccagcgc ccgcgagagc aggtcgtccg cggcgacgtg
     1681 gctgccgtgc gactggcggt cctgcgcgat cctgatgcac gcccgcgcct gcccgaggtc
     1741 gtcgcccgcg ccctcgaaca ctggcagcgc ccactgggcg acggtgcccg cgctgctccc
     1801 gtcgggcgcc gcggacaccg cggccagggc caggcgcgcg tgcgcggcct ccaccgggcg
     1861 gaccgcgtcc cgcgggccgg cgtccgcggc gtcgagcacc tggagcagca gcgcccggcc
     1921 ctcgtccgta cggcctgtcg ccagcaggac gtcgccgagc cgccgggcgg cggccgccca
     1981 ctccggctct ccctcggcgg cgagttcgac ggcgcgctcc agcagtcccg cggcccacgc
     2041 caggtcggag cgggccagtg ccctggaacc ggcgtcgatc agcaaccgta cggcgcgcag
     2101 ccgcagttcc tcggtgtgcg ggccgagcac gcccagctcg gcgcggtagc ggtaggcgcg
     2161 ctccaggtgc gcggccaccg ccgcgaggcc ctcggcggag gcacctcgcc ccgccgaccc
     2221 ggacggcggt gcgacccgcg cggcccccgg cgccggatcg gcccggcccg gcgtgcccgc
     2281 gagcggcgcg gcaccggcca ccgcggccgg gcccgccacc gcgtacgcgg ccatggcggc
     2341 ggccgtcgaa ggccccccgg acagcgcgcc gccggccgcc gcgaccggac tccccggcgc
     2401 accgccgacc accgcccccg gctccgccaa cacctccgac agcctactcg cctgccccgt
     2461 ggcggcgctc ggacttcccc cggacgcaga ggcgttgacg gctccggccg ggctccccga
     2521 cccgcccccg gacaccgcat tgcgccccgc cggaccgtcc cccgctcctg ccggaccccc
     2581 ggcggcaccc gaacctcccc cgggcgcggc cgcgttggcc ggacgggtcg cggccgccag
     2641 gcgttcggac agcgcgaggg ccgcgtgttc gtggcgctcg gcccgggtcc gcttggccat
     2701 cgactggtag gtgacctcgt ggacgagccc gctgctgaag cgcaacgggt aggtgcccgg
     2761 gcgcggccgg tccgcgggcg acagcaggcg gtgccggccg agccgggcga gtgccgcgcc
     2821 gaccgggccg ttcagcggcg ggcgcggcgc gggcccgccg gcttccggcc gcgtcccgtc
     2881 gtgcagcgcg ccgccggggg cgccttcggg gtccccggcg accaggtccg ccacctcgtc
     2941 cgcggtgaac tcccggccgg cgacggccgc gatgtcgagc gcggcgcgct ccgcccggcc
     3001 gagcgcgccg atccgcgcgc cgagcagcgc ctggagggtg gtcggcaggt cgccgccgcc
     3061 gtccggccgg tagccggagt ccggctgggt gagcgcggcg atgagctgtt cgaggtagaa
     3121 cgggttgccg cccgcggact ccagcacctg cggcggcacg cccgtacgcc ggcggggccg
     3181 ggcggcccgg ggcccggacc ggtccgggga cgccgcgccg tcccagtgcg cgccgacctc
     3241 ggtcagcgct tcggccacgg cctcggcctg cggggtggtc aggcccggca gggtcagcgc
     3301 ccgcgcgccc gggccgcccc acccggcgtg gcggtcggcg aggtcgggtc gggccgcgca
     3361 cacgaacagc accccggccg aggcgagttc ggcacgcagc gcggtgacca tggccagcag
     3421 ggggtcgctc gcccagtgca ggtcgtccag caccagcacg accggccggc ggcgcgccag
     3481 tacggccagc aggccggtca gggccgcgca ggtgtcgtcg gtcgacgggt tgggggtgcc
     3541 gtcctccagc agtccggccg agagcacggc cagcgcggcg ccgacctcgt cgccttccgc
     3601 ggcgtcctcg gccgcggccc cggccccccg cgtgtccccg tccccgtgcc cgcccgcgcc
     3661 ggccgccggg ccgccgggtc cgtccggccc gtcaccgccc cgcgcgtccg ggagcagcct
     3721 gatctccggg aactcgtcga ggagttggcg gacggcctcg gcgagcggcg ccaggctgcc
     3781 gcgctccccg tacggccggc agcggcccga gccgtacgcg aaggcaccgc cggactgctt
     3841 gcgccactcg tggatcagcc gggtcttgcc catgccggcc tcgccgaaca cggtgaccag
     3901 gttcgggccg cggccgtccc tttccgccgc cgcggccaac gcctcgcgca gggcgtccag
     3961 ttggcggtcc cgcccgacga agggcacgtc gaagcggcgg gtaacctcgg gctcctcctc
     4021 gaccaccgcg agcaaccggt aggcggagac cgcgtcctcc ttgcccttga gcagcagcgg
     4081 cccgaccggc tccgtcagcg cgcgggcgcc ggcggcccgg aggctctccg gaccgatcag
     4141 cacctcgccc tcgcccgcgt tctgctccag ccgggccgcg acgttgaccg tctcgcccga
     4201 caccagcgcc tggcgcgacg acacgtccga cgcggtgacc accggcccgg tgttgatgcc
     4261 gatccgcacc ccgatccgga tgccgagcga ggggcccagc tcggtgtcgt tgagccgctg
     4321 gacggcctcc agcatggcca ggccggccgc gagggcgcgg gccgcgtcgt cctcgtgggt
     4381 caccggcacg ccgaagaccg ccatcacggc gtcgccgatg aacttctcga cggtgccgcc
     4441 gaactcctcc aggcactcgc gcatccggtc gaagtagcgc agcaccaccg tccgcagcgt
     4501 ctccgggtcg agcacccccg acagcgccgt ggagcccacc aggtcgcaga agaccacggt
     4561 cacgaccttg cgctcctcct gcggcacacc cgccggtttg gaggcggccg gggtgccgca
     4621 ggacgggcag aagcgcgcct cggacggcag ttcggcgtcg cacgcagcgc agcgcatggt
     4681 cgtgtccctt cccgctggtc gtggagcggc tcagaagagc gcgccgccgg cgatctcgct
     4741 gtgggcctgt acctcgggtc cgacctcgtc caaccgcgcc ttgatgtcga gcatcaccga
     4801 cagttcctcg gcgctcagcc cgcgcagcac ctcctgctgc tcctcggtga gttcggcgac
     4861 gccgaacccg tgtgcccgga gcacgtccag ggtgtcgtcg gccggtcggc cgccctcccc
     4921 gctccgtccg gtcccgccgt cgtcccggcc ctgcgccgcc ccgtcggtca tgaggtgtgg
     4981 gtcctttccc tggagtgatc ctgctgcgct gcccggccga tgtgcgcgaa cagctccacg
     5041 agtccgtcca cggtgtgcag cgcgctcatc acgaccgcgt tcaccagggg cgggtcgagc
     5101 ggcagcccgt cgagcagtgc gaacagctcg gcggtgtgcc cggtgtccag ttcggcgtgc
     5161 ccgcgtacgg tgcgcagcgc cgcctcgggc actccggcgg cggcgatctc gtcggccagc
     5221 cagggcgcgg gcgcgttgct ctccagcacg gcgatgtagc cgagcagcgc gacggggtga
     5281 tggtgctcga tccagtagta ctgggcgccg gccagccggg cgacggcggg cgacggctgc
     5341 cggtcgcgta cggccgcggg gtccccgccc agcgcggcga tgtcgtcgag cagccagtcg
     5401 tcgtggccgc gttcctcctc gacgtggacg cgcaggtacg ccgcgagcgg ggcaccgacc
     5461 gcgtcgccga ggtccgcgca gcgggacgcc gcgcgctgca tcagcgggac ggacgcgcgg
     5521 atcaggccgt gcatgtcctc caggtagcgg ccgtagcgcc gggccaggcc cggtgcccgc
     5581 cacatggccg tggtggccgc ccgcaccgcc ggcgcggtca gcagcagccg ggcgctcagc
     5641 gccgtaccgg ccgggaccgc cgtgccggca gtcaccgtgc cgctccgtgg agcgcgacca
     5701 ggtcggcgta gggagcgcag ccgtgccgcc ggaccagcgc cacggcgccg gcctcggcct
     5761 ggccgcgggc ggcgtaccgg tccagcaggg cgccgacggg cccggcgccg gcggcggtcg
     5821 ccgcggccag cacctcgggc cgctcggcga gcgcgcggca gccgtcgcag tagcccggac
     5881 gcggggccgc ctcgtcggcg gcgccgtagc ggtgccggag gtgggcgggg ccgacggtcc
     5941 tgatcatccg cagcaccggc gaccggaccg cgcgggcgct gatcgactcc cagtcgtcgg
     6001 tgccgatgtg gccgagggtc aggtgggcgg gggcgggtct gcggtccacg accgcctggt
     6061 tgcagcaggc gacgacggtg ccgtcggccg cgaccaccgg ccacgcggcc atcgagcagg
     6121 gcagcgcgcg ctcggggtcg ggcgaggcgg tgtccgcggc ggcccaggag gccgcgcgcc
     6181 ccacccggcg cagcgagttg accagcatcg ggacgcggga gccgaaggtg cgccggatgt
     6241 cggcggtgac atcggcgagg tacgggtcgt ccgcgccgct gccgaccagg tggaagctgg
     6301 cggcgacgcc ggcgtccagg acccgccgga cgagggcgaa cacgggggcg cggccggtct
     6361 cgcgctcgtg gtaggcgtcg acgctcaccg agaagtggtc cacggccgtg acggcccgcc
     6421 agatccgctc gggcacggcc gcgacctgcc cggggtgccc ggggcggtcc gcccggccgg
     6481 cgaagaaggc gccggtgagc agcgcggtcc gggtgcccgc cgcgcgcgcc gtcgcggcca
     6541 gttcggtgac cagctccggg cgcagcagcg gttcgccgcc ggtcatcatc agcacggacg
     6601 ggtgcgccgc gggcgtgaag gtgccgacga aggaccgcag ccgcgccgcg tccggctcgc
     6661 ccgaggccat ggtcgcggag gtggagcagt gcgcgcagtg cagggggcag cggccggtga
     6721 cggtcaggag cagccccgca cccggcagcg ggcgctgcgt catcagttcg gcgagttcca
     6781 tcgcacgctc ctcatcgtcc ttccgaagtg tcggcggggg cggttcgagg cggggtagga
     6841 aacggtatgg aagcggtaaa tccgcaggtc ggggcccggg acaccgttgg cccctggagg
     6901 tgtcgcgcgc ggcggtgcgg aaccggtcgc ggccgccccc gcgaaggccc gtccggcggt
     6961 cccgcggtgc cccttcccga ggcccgcgcg aggccgcttc cgcagggctc cggcgccggc
     7021 ctcgcccggg cccgcgcgag gccgcttccg cagggctccg gcgccggccc gggcggcggt
     7081 ccgggcggcg gtccggaggg cggtccgggc gccggctcgg agggcggcgc gggcgccggc
     7141 tccggcggtg gtccgaacgg ccgcctcggg gagggtccgg gcggccggcg cagccgcgga
     7201 cggtcggcag tggcgcgcgg ccggttcggg cggcgcggcc ccctcgggcg ctgccgccgg
     7261 cccaagcgct gccgccggcc caggcgctgc cgccggctca ggcagtgccg ccggctcagg
     7321 cggtggccct tggcagcggc tggacgtgtt gcagggcctg ttcccgcgcg tacacctggg
     7381 tcagccgcgg gagttcgtag tgcgcggcgt gcgcggtgac ctcgcagtcc ggcgcgatca
     7441 gcgcgccagc gtccatcagg gactccagct tgtgcagggc gcggtcctgg tcgcaggtga
     7501 gcgcttcggc ggcctgacgc agcgtgaagg gcccctccgg cagctccgcg agcaggcaga
     7561 gcgtggtccg gtcggccgtc ggcaggtcgt tccacccgct gtccagccgg ggccgcacgt
     7621 cggtgtcccc ggcgaccagt tcgtccagca ccgtcctgcc gtcggccagc cgggcggcgt
     7681 actcgcccag cggcaggtag cggcgtaccg cgagcttcag gccgctgacc cggacggcga
     7741 gcggcagcat gcccgtggcg gccacgatct gttcggccga cgccggacag gaccgcagcc
     7801 ggtcgtggcc gacgatccgg ccgagcagtt cgaggctctc ggaccggtcg aaggccgcca
     7861 ggtccagccg gttcgccgac gccaggcccg cgagctgggc gcgggacgtg accaggacgg
     7921 cgctgccgcc ggtgtccggc acgaggggcc gtacggagcc ctcgtcggcc gcgtcgtcca
     7981 gcaccagcag tacccgccgc ggctccagcc aggtccgcca cgcggcggcc gcctcctcgg
     8041 tgccggcctc ctgggcgccg gcccggcgga ccccggcccc gggcgccgcc ccgggcaggt
     8101 cggccgtgcg ggccggctcc ggaaggtcgg ccatccgggc cagctcggcc accagcgagg
     8161 cggccgtgcg cggccggccg tcctcgtcgc gcatccgcag cagcacgcgc ccgtcgggga
     8221 actccgcggc gagccggtgc gccgcgtgca ccgcgagcgc ggtcttgccg gtgccgaccg
     8281 ggccggtgag cagtgtcagg cgccgctcgc cggccagcag gccggtcagg tcccgcaggt
     8341 gccgctcgcg gccggtgaag tcggcgaggt cctgcgggag gacggtaccc aggacaccgc
     8401 cgggacggcg cgccgcggcc ctcgggccgg cggcgcccag cgggccgagg gagctgccgg
     8461 gttgctgcgg gccgccgtcg aggatcgacc ggtagagcgt ctccagggcg gcgctgggct
     8521 ggagtccgta ctccgcggcg aggagctggc gcagcgccgc gtaggcggcg agcgcctcgg
     8581 tctgccggcc ctggtcgaac agcgcggtca tctgcaccgc cctgagccgc tcccgctccg
     8641 ggtgccgctc gaccaggtcc cctacggtct cggcgacctc ggtggcccgg ccgaggcgca
     8701 gctccacctc ggcccagtcc tcgtagacct ggacgtagcg gctgtcgagc cgctcggcct
     8761 cggacctgac ggcgggggag aaccgcagct cgcgcagcgg gagttcctgc cacagcccga
     8821 gcgcctcgcg cagcatccgg gacgcggggc ccagggcgcc ctgcgccgtg gcctcgcggg
     8881 cgcccctggc caggtgccgg aaacgcagca cgtccagttc gtcgtcgcgc acccgcatca
     8941 ggtagccgcc tgcgtggtgc gcgaggcgct cgccggcgcc ggcccggtcc agcagtttgc
     9001 gcagcgcgga gatgtagacc tggatgttct tgcgcgcggt gcgcgggggt cggccgtccc
     9061 acaaggtgtc ggtcaacagg tccagcgaca cgggggtgtt ggcacgcagc agcagcatcg
     9121 ccagcagcag ccgctgcttg agcggaccga gcgggaaggg gccctcggcg gttccgacgg
     9181 acagggggcc gaggacggtg agccgcaggc tgtcgtgcag tggttcggcc atctctggtt
     9241 tcacctttcc caccgacgga cccgggagcg gatcgtgagc tgagatgaat gacatccggc
     9301 ggatgactta tatcaaagga tgcggcccgg gtgaacacgg caacgtccct ccgcgccgcg
     9361 cgagttgccg tcaacacctt ttccacctgc gacgataccg cccccatacc gcgggtagac
     9421 cggttccgaa tcgaccccgc ctagcgtttg ggatgtccga gcaacgcttc acatccgctg
     9481 agacgaggag acgatcatgg ctgacgccgt cgaccccacc aacgaggaca ccaccgccga
     9541 gaccgagaac gaggtggagg cgcactccga ggccctcgac ctccaggaga tgggcgtgag
     9601 cgggctcgag gcccccggca gcacggtcag cctggccgcc tgcgcctgag ctacccgtgt
     9661 gggtggcgtg ccgatgcggc gcgccaccca ctcgtcgttt cgcacccgcg cggcccggcc
     9721 ggccgtgccg ggcgcccgga cccgacagga gacaccatgg ccgatcccgt ggaccccgct
     9781 tcctccgcag tgcccgacga cgagcagacc gcccccgaag cggccgacgg cgagtccgag
     9841 gtcgaggcgc acgtcgccaa cccgctggac ctccaggaga tgggcgtgca gacctccttc
     9901 gccgacaacg tcatcggctc gacgagcgcg accagcctga tctcctgctg ctgacgtccg
     9961 caccgccgcc gcaccgtcga cccagcaccg gagaggcccc atgatcccgt tcctttacgt
    10021 cgtcgcggac aaggagttct acgcaccgct ggagaccgcc cgcgaccgcg gcgaggtcta
    10081 ccggcccgcg ggggtgccgg acggctgggc cgggacggag tccgggatct ggacgatgtg
    10141 gcaccggggc cggcagttgc gcggtgtcga ggacggctgg aaggtgcacg tgtccgcgcg
    10201 gcccggccgc cagcagcacg tcctcgacac cgtggccgcc gtctgcttcg aacaggacgt
    10261 cgccttcaag cacatgtcct gctcgctcgc ctactggtgg atgcaccaca agcaggccgc
    10321 gcggcagcag agcggcaagt tcgtcgccgc ctatcccacc gacgtcgagg ccgcccgcgc
    10381 gctcatggag cggctgcgca ccgaactcga cggcgaacag ggaccgttcg tcctcaccga
    10441 ccggcgctac cgcgactcgc gcaccgtcca ctaccggtac ggcgcctacc tgccgcgcga
    10501 ccgcgtcaac gccgacggca cctacaccat gctgctgcgc cgcccggacg gcgtggtgga
    10561 ggaggaccac cgcggcgtct ccttccacct gccggaggga gtggtcgacc ccttcgtcaa
    10621 gcgccgcccc gccgcggcgg gcacgaaggc cgcggccccc cgccggaagg ccggcacccc
    10681 ccgcacggag ccggtgacct tccacgggta caccttcgag gaggccctcc agttctccaa
    10741 cgccggcggc acctaccggg cgcgggaact ggccaccggc cgccaggtct tcatcaagga
    10801 ggcccgcgcg cacaccggcg tggcccacgg cgagcgcacc gcacccgacc agttgcggtc
    10861 cgagcaccac acgctgaccg ccctgcacgc cgcggccccc ggcctcgccc cgcagccgct
    10921 ggagctcttc cacgagtggg aacacgacta cctcgtcacc gagttcatcg agggcgagac
    10981 cctccagcgc tggatggtcg cccaccagcc gatgctcggc accggccggc tgccccacga
    11041 gttcgacgac tactacgccc gctgcgagaa gctgctcgaa cgggtggaga gcgcgctgga
    11101 gcggctgcac gccgccggct acctcttcgt ggacgtcagc cccggcaacg tgatggtcgg
    11161 cgaggacgac agcgtccgac tggtggactt cgaggccgcc cagcgcgcgg acgccgacga
    11221 gatcctggtg atgggcaccc cgggctactc cccgccgccc gaactcgtgg gcgacgaccg
    11281 gcggatccac gacgacttcg ggctggccgg cctggccctg ctgctcctcg gccccttcca
    11341 ccagtcggcg cggcgcaacc ccgacgcgct cgcgcacctg cgcggcgaac tgctggagcg
    11401 ggcgccgctg ccggagccgc tgtggcagaa ggcggtgcgg ttccacccgc cgcgcgccgc
    11461 ggcggacggc gcgctccccc taccctcgcc cgaggaggtg gccgccgacc cgctgcggca
    11521 cctcgccgac ctgcgcgacc gcaccgcgga cgcgctggtc gcgatggccg aaccggacca
    11581 tcccgaccgg gtgttcccca ccatcgccga cggctaccgc accaacaccc agtgcctggc
    11641 ctacggttcc gccggtgtcc tgcacgccct gacccgcgcc gggcgcgccc tgccggacgg
    11701 cgcgctggag cgcctgcgca ccgacgcctt cgaccggatc gaccgcctgg gccccggact
    11761 gatggccggc accgccggca tcgcctgggt gctggccgac cacgggctgc tggacgaggc
    11821 gcgggacctg ctcgccgccg cggaccgcca cccgctgatc acctcgggcg cctccgcgac
    11881 gctcttcggc ggcagctccg gcctcgccct cgcccacctg gcggtgtacg gccacacccg
    11941 cgacgccgcg cacgtcgagc gcgcggccga actcgcggcg gcgctgccgt ccgacgccgg
    12001 cctcgcaccg ctgctcggcg ccgacgacgc caccggcctc atgcacggcc ggaccggcat
    12061 cgcgctgatg ctccagcagc tcgccgccgt caccgggtcg gacgacggac tggagcgcgg
    12121 cgtccggctg ctgcacgccg aactcgaccg cgccaccgac cccgacgcgc ccggcctggc
    12181 cttcccgatc tccgccaccg acagccgcag cctgccgtac ctgtactccg ggtccgcgtc
    12241 gatggcgcac gcggtcgtcc gctacacgcg gaccgtcgac gacgagcggc tcgcgcaggc
    12301 gctgccgcgg ctgctggcgt ccacccgcac cacctacacc gcgatgtccg ggctcttcca
    12361 gggcctggcc ggactggggt tcgccctcgc cgagcaggcc cggctgaccg gcgagaggtc
    12421 cgcccgggcc gacgcggtcc gcggcgcgcg ggggctgttc aagttcgcgg tgccccaccc
    12481 gaccggggtg cgcttcctcg gggaccagct catgcgcttc agcgcggacc tgtggagcgg
    12541 ctcggcgggg atactgctct tcctgacgca gttgctggac cccgcgcccg acccgctgtt
    12601 caccgtggac gcgctcagcg gcgcgcacgc ccgtacccca gcggccaggt gaggtgccga
    12661 tgagcgtgga gaagaccgac ggaacgaacg ggtcgcccac gggcgacgcg cccgccgccg
    12721 acccgccgga cggcgcctcg gcgggctggg ccgccacccg cgacgtcaac ctctactggt
    12781 gcgggcagac cgcctccgcg ttcggctcgg tcttcaccac gatcgcgctg ccggtggtgg
    12841 cggtggtgca cctcaacgcc tcggccgggg ccatcggcct gatcagcgcc gccgcgaccg
    12901 cgccgatcct gctgctcggc ttcccggcgg gcgcgctcgc cgaccgcctc gcccacccgc
    12961 gccgcgcgct gatcctgctc gacctgatct gcgcggcggc cgtcggtgtc gtcgccctcg
    13021 ggctggccgc cggcgccgtc tcgctgctct ggctgggcct gctgtgcgcc atcatgggcg
    13081 ccacgtccac gctctccatg tcggtgtact tcctgcacct gcgccaactc gtcggcccgg
    13141 acgggatcgg cggcgcccgc gcccggctcc aggccgggca gtacggcgcc gcgctcgtcg
    13201 gccgcctgct cgccggaccc gcgatcgcgc tgctcggcgc ggccgccgcg ctctccgtcg
    13261 acgtggccag ctacctgctc agcgccgcgg ccctggtcac catgcgctcg accgacctgg
    13321 tcccgcgcgg gcccgcgccc tcggtgctca cctcgctgcg cggcgcgatg gcggggctgc
    13381 ggctgttcac cggcgacggc ttccaccgcg cgctgggcgt gttcatcgtg gtgccggccg
    13441 cggccctggc cggtgtcacc gcgctgaccg gaccgttcct gctgcgggtc atccacctgc
    13501 cgaccgccgc ctacggctcg ctcttcgcgc tgtcggggct gatggggctg tcgggctccg
    13561 ccgtcgccgg gcgggtgctg gcaccgggcc gggacgcccg gcgggtgctg ctgggcggct
    13621 tcaccgccgc catgatctgc agcctgctgc tgccgctgtc cggcggtccg ctgccgctgg
    13681 ccgcgttctg cgcggcgatg ggcatcggtc tgccgatctt cttcggcgcg atcgccaacg
    13741 tggccgtcag ctccgtcctg gtcgcctcga tgtccgagga gacgctcggc cgcgcgatgg
    13801 ccgcgctcca ggtgtgcgtc gccacggccg gcctggtcgg cgcgctgggc agcggtgtgc
    13861 tcggcgactg gctcggggtg cgcggagcgc tgtgggcgat gggcctgctc gcgctgggcg
    13921 gcatcgtgct gagcctgccg cccgccctgc gggccgcgcg ggtggccgcc gacgtgcccg
    13981 aaccggagcc ggccccggtc tgaccaccgg ttcccccgac atggccggaa ttcgacttgc
    14041 ccggccggtt cggcgttccg ccggcgcggc cgggcgcgcg gcccgaacgg acagcgacgt
    14101 ccgtgtcacg cacggaagtc ggccccggcg gcggacacac cggcaccccc gcctttgtcc
    14161 cgtcacacag ttcacatcgg ccacagggcc gacggccatt ccgggatcgg gggagcaccg
    14221 gctacgatga ggccggggga agaacagctc ggcctggccg gtactactcg gggggaggcg
    14281 gacgatggac aagcgtgttt ccgccgtgtc gtccgccgcc ggacgccggg ccggcaccgc
    14341 cgccgcgtcc ccggccggaa gcggttccgc cgccgacgag cagtcccccg cggccccgcc
    14401 gcccgcgccg acctccacgc tcgccggcaa gatcgacgcc ctcttccgtg tcgtccgccg
    14461 ccccaaccgg gagccgtaca gccacgagga ggtcgcccgc gcctgccggg aggccacggg
    14521 cgagagcttc tccgcgacgt acctgtggca gttgcgcacc ggccggcgcg acaaccccac
    14581 caagcgccac ctcgaagccc tcgcccagtt cttcgacgtc cccgtcgggt acttcttcga
    14641 cgacgagcag ggcgcggcca tcgccaagga gctcgaactg ctcggcgcgc tgcgggacgc
    14701 gggcgtgcgc agcatggcgc tgcgcgcggt caacctctcc cccgaggacg cggccacgat
    14761 cagcgacatg atcgacgtcc tcgcccgccg ggagcgcggc tccgcggggc gcgggctcta
    14821 gggccggtcc ggcggaaccc gccgggctca ggcgcccggc accgcacctc cctgcgttgc
    14881 cgaaccaccc acggacgacc cggtacgagg acgtctctcc gccttgcgac gcaacggcac
    14941 cggacaccgc gcgcccgacc ggcacgatcc gccggacagg ccccgggacc tgtccggcgg
    15001 aaacccgcgg ccgggtggcg cgcggtcgcg gccgccccgt gggccgcgcc ggatcagccg
    15061 acctgggcgc ccttgcccag cgcgatcacg cccgcctcgg agacggtgta cagcgcgcgg
    15121 tcccgctcgg ggttgacgcc gatggtggcg ccgggcggca cgtccacgtt cttgtcgagc
    15181 accgccccgc ggacgatcgc gccgcgcccg acccgcacgt tgtggtgcag caccgagccc
    15241 tggacgacgg cgccggtgtc cacgacgacg cccggcgaga gcaccgagcg cgtgacctgg
    15301 ccgcgcacca cgcagccggg gctgatcacg gactccccca cgatgccgcc ggcggcgatc
    15361 ttcgcgggcg gcagcgaacc ggggttggtg tggatcggcc agtcgcggtt gtagaggctg
    15421 aaggcgggcc ggtcggagac caggtccatg tgcgcgtcgt agtaggcgtc gagggtgccc
    15481 acgtcccgcc agtagccatg gtcgcgggcg gtctcgccgg gcacgtggtt ggcgtcgaag
    15541 tcgtagacgt gcgcggcgcc ctgcgcggtc agccggggca ggatgctgcc gcccatgtcg
    15601 tgcaccgact gcgggtcctc ggcgtcctcg tgcagcgcct ccagcagcgc cttggtggtg
    15661 aagacgtagt tgcccatcga ggcgaagacc cgcccggggt cgccgggcag ccccggcggg
    15721 tcggccggct tctccaggaa ccgttcgacc gccaccccgt cggcgccggg ggtgatcacg
    15781 ccgaagccgg aggcgtcggc cctgggcacc ttgatgccgg ccaccgtgac gcccgcaccg
    15841 tgctccgcgt gctgctccag catctgccgc gggtccatcc ggtagacgtg gtcggcgccg
    15901 aacaccgcga cgtagtccgg ctgctcgtcg tggatgaggt tgagcgactg gaggatcgcg
    15961 tccgcgctgc cgaggtacca gcgcgggccg agccgctgct gggcgggcac cggcgtcacg
    16021 tagttgccca gcatgttcga catccgccag gtcgtcgaca cgtgccggtc cagagagtgc
    16081 gacttgtact gggtgagcac gcagatccgc aggatgccgc cgttgaccag gttggacagc
    16141 acgaagtcga ccaggcggta cgacccgccg aaggtcaccg cgggtttcgc ccggtccgcg
    16201 gtgagcggca tcagccgctt ccccgccccg ccggccagca ctatgccaag gaccgaaggt
    16261 ccaccaccgc gcatcggcgc ccctttgttc gtcgtcgtcg gtcgcggagg gccggccgga
    16321 cggccgcctc cgttcccgtg agccgtgtgc ccgcgtgccg cggaccgatc cgcggccgcc
    16381 ggccgttctc ccgcgccgtc cgcccgcaac aggccccagg gcctgtccgg cggaccctgc
    16441 cgggctcacg gcgcccggca ccgcacctcc ctgcgttgtc gaatcatcca tgtacgaccc
    16501 ggtacgagga tggttctccg ccttgcgatg cacggcaccg gaccccgcga gctcgaccgg
    16561 cacgatccgc cggaccggcc ctaggcggtg ccggccttcg cgaccgcctc gtacaggtcc
    16621 gcggtcctgc gggcgacggc gtcccagccg aactcgcgca ccgcgcgcag ccgccccgcc
    16681 tcccccatgc gcgccgcgcc cgccgggtcg ccgagcaccc ggtccagggc ccgggtcaga
    16741 ccggcctcga actcctcggc gtggccctcc cggtagggca ccagcagccc ggtctcgccg
    16801 tcctcgacga cctcgggtat gccgccgacc gccgaggcga ccaccgccgt accgcaggcc
    16861 atggcctcca ggttgacgat ccccagcggc tcgtacaccg acgggcagac gaacaccgcc
    16921 gcgtgggtga gcagttgcac caccgcgggg cgcggcagca tcgccggtat ccagtgcacc
    16981 ccgtcgcgca ccgagctgag ctcgtcgaag agcgaccgga actcccggtc cagcgcgggg
    17041 gtgtcgggcg cgccggcgca cagcacgagt tgcgcggcgg gatcgatcgc gcgggcggcg
    17101 cgcagcaggt gcggcacgcc cttctgccgg gtgatccggc cgacgaacag cacgtagggc
    17161 cgggccgggt cgatgccgag gcgggccagg gcgtcggtgc gcgggtcggc ccggtaggtg
    17221 gtggtgtcga tgccgttgcg caccacgtgc acccggtcgg ggtcgaggcc cgggtagcag
    17281 gacaggatgt cgccgcgcat gccgtcggag accgcgacca cggcgtcggc cgactccatc
    17341 gcggtgcgct cggcccaact cgacagggcg tagccgccgc cgagctgctc ggccttccac
    17401 gggcgcagcg gttccaacga gtgggcggtg agcacgtgcg ggatgccgtg caggagcttg
    17461 ccgaagtggc cggcgaggtt ggcgtaccag gtgtgggagt gcaccaggtc ccggtcgccg
    17521 agcgcggcgg acatctggag gtccacggcg aaggtgcgca gcgcgtcgtt ggcgccgtcg
    17581 aggccggccg gggcgcggtg gcggaagacg cccgcggtgt tcccctcgcc ccagcagtgc
    17641 acgtcgaggt cgaccagcgg gcgcagctcg cgggcgagga actcgacgtg cacaccggcc
    17701 ccgccgtaga cgtccggggg gtactcccgg gtcagcagtg cgaccttcat ccggacctcc
    17761 acccgtcggc aaccgtgctc cttgccttcc ccggttccgg gcggagctat cacggtgaac
    17821 ggctcgggtt ccgcggtgcc cccgcccccg gtcggacccg gtcgggcggc cgcacccgac
    17881 cggcgggcgc cggcggggac gcccgcccgc gcgccggcgc gcggacgcgg cgggggcgcg
    17941 gtgcggttga cccgtattcg gccaaggtcg ccgcgttgcc cccggttgcc cccggttgcc
    18001 acccgtttgc cgtccatgac cccccgcagt cgccggggtg ggcttttact gacgaatggg
    18061 gcaccggtgc acgtgtgggt cgcgtgggac cggctcacag gcaagcacaa ccccgtggtg
    18121 cacgcggcaa tacggccgat cccgccccgg cgggcccgga gcggaatgac gctttatgga
    18181 cggctgcggc cccctggccc cgggcacacg tatgggagag acgacacgtg atgaccaccc
    18241 cccacccccc cgcacctctg ccgctgcgcg caggagagcg gttggcactg gcgctggcga
    18301 gagaagagat gatgcaggac taccaccggt gggagaccga cccggcgacg gtcgtcgggt
    18361 tcggcgcccg ctggccggtg tcctgggagg tgttccgggc ccggttcctg agcagtcaca
    18421 cctcgcggca ctaccagctc ttcgaagtgg tcaccacgga gggcgcggtg ccggtcggca
    18481 ccacctccct caacgtcgac caggcggtca acaccgccga actcaccctg gtgatcgccc
    18541 cggagcaccg cggccggggc tacgcggccg aagccaccgc actcacgctg gactgggcgt
    18601 tctccatcgc gtcgctgagc gcggtgtggt tggaggtgct ggccccgcac accgccgcgg
    18661 tcaacgccta cctcaaggcc ggtttccgca ccgccggccg gctgcgcagc gcggcgctgt
    18721 ggcagggccg gcgggtggac aagctgttcc tggactgcgt gcccgacgac ctggcagaaa
    18781 agaggtgatc cgagaatgtc ctgccccgac gtgaactgcc gcaagggcgg ctgcaccacc
    18841 gaccccggtc aaggccggcc ggcccccgag cgcggtccga aggcatgacc ccgctcgtca
    18901 cctgccgtac ccccgcccgg cgggggtacg gccccgggcc ccacgggccg gtccgggcaa
    18961 gtacggtatg cgggaccgtg tggtgaccag ccgcggaggg gaacgcaccg atggcccagt
    19021 tcgacatgcc gatagagcag ctcaggacgt accgcagcga gtcggtcgag ccaccggact
    19081 tcgaccgctt ctgggccgac accctggcgc aggcccgcgg ccacgacctg gccgcgcggt
    19141 tcgagccggt cgcgacggcg ctgcggaccg tggacacctt cgacgtggag ttctccggct
    19201 tcgacgggca ccggatcaag ggctggttca cggtgccggc cggtgcccgt gaacctctgc
    19261 cggtggtggt ggagttcatc gggtacggcg gcgggcgcgg cctgccgcac gagcgcctga
    19321 cctgggcctc cgcggggtac gcgcacttcc tgatggacac ccgcgggcag ggcggctcct
    19381 ggtcgaccgg cgacaccccc gacccggtgg gctcgggttc ggcgaccccc ggcttcctga
    19441 cccgcggcat caccgaccgc gacgagttct actaccgccg ggtgatcacc gacggcgtgc
    19501 gcgcggtgga ggcggcccgt acccacccgc tggccgacgc ctcccgcacg gtggtgaccg
    19561 gcgtcagcca gggcggcggg ctgagcatcg cggtcggcgg cctggtgccc gacctcgtcg
    19621 cggtcgcgcc cgacgtgccg ttcctgtgcg acctgccgcg ggcagtccgg atcaccgacg
    19681 cgttccccta ccgcgaggtc gcgtcctacc tgtccaccca ccgccccgag cgcgagcggg
    19741 ccttcggcac cctcgcctac ttcgacaacg tgcacttcgc cgcccgcggc cgggcgcccg
    19801 cgctgttctc caccgccctg ctggacgcga cctgcccgcc ctccacggtc ttcgccgcgt
    19861 tcaacggcta cggccacgag gaccgcacca tcgaggtcta cgacttcaac ggccacgagg
    19921 gcggcggcgc ccaccacgag gccctgcgcc tggagtggct gccgaagtac ctctgatccg
    19981 cgccctcccc cggccctgcc gcgcgttccg ccgtccgtcc gtcccctccc gtgccgaacc
    20041 gcacgggcgc gcggacgtgt tggcggggac cgtttcgaac ctccgcgaaa aaaagaggaa
    20101 tacgtcggcg gtcggggggc aggaggcggt tgaccgtcct acaagtgcga ggcgatgacg
    20161 tgaccgcgaa tgcgcagcag tcgagtagca caagcgggac cgcgacctgc ctgcggcagg
    20221 cgggttcggc ccaccaggag gcgcccggcg ggctcccctg gatcgaagac gcgaccgcgg
    20281 ttgccccgca ggacgcgcgc gtgctctcga aactcttctt cgaccgactc caggaactgg
    20341 aggaggggac ccacgcctac agctacgccc ggaacaccct gatcgagatg aacctggcgc
    20401 tggtgcactt cgcggccggc cgctaccgga accgcccggg caccgaccgg gaggagatca
    20461 tccaggtcgg cacgatcggg ctgatcaagg cgatcgaccg gttcgacctg tcccgggaga
    20521 cggagttcac caccttcgcg atcccgtaca tcgtcggcga gatgaagcgg ttcttccgcg
    20581 acacctcgtg ggcggtgcac gtgccgcggc ggctccagga gctgcgggtc gagctgagca
    20641 aggcgaagga gcacctggcg ctgctgctcg accgcgaccc cacggtgccg gagctggccg
    20701 cccacctgga actgaccgag aacgaggtgc tggagggcct ggtcgcggcg aacggctaca
    20761 ccgccggatc gctcgacatc ccctggtccg acagcgacgc gggtcccgac agcgacggcc
    20821 gcaccctcgc cgacaccatc ggcgactgcg acccgacgat ggagctgatc gagaacctgg
    20881 gcagcctggc gccgctggtc gccgaactct ccgaccgcga ccgcgacctg ctgcggatgc
    20941 gcttcgtgga ggagatgacc cagtcccaga tcggcgaggt gctgggatac tcccagatgc
    21001 acgtctcccg gttgctgagc cggatcgtga agaagctgcg cgcgggcatg ctggtgcagt
    21061 aggaggacgt tcttccggcc gggggccggg tgcgggccgc gagcccgtac ccggcccccg
    21121 tcgtttgccc gcaccccacg cccgcaccca ccacgcccgc gcccgcgccc gcgcagcgtg
    21181 ccgcacctcc cccgcacccg cgccctcgcc ccacgcgcgc atgccgcgcc ccggcccggt
    21241 gagcgccggg ccggggcggg ggggttcacg ccggatcggg gcgggtcacg ccggaccgct
    21301 cgacgcccgc ggcgtgccgg tcggcgacgc cgccgtcgcc gggccggccg aggagagcgg
    21361 cgtcgcgatg tcctccaggg acttctgctc ggcgttgacc gcgaagaccg ccgccaccag
    21421 cccgcccgcg cacatcaggg ccgcgccgat gcagaacgcc agcacggtgt cgcccacctt
    21481 ccccgaggag gtgaggtcgg agaagaccag cgggccggtg atgccgccgg ccgccgtacc
    21541 gaccgcgtag aagaaggcga tcgccatcgc gcgggtctcc atcgggaaga tctccgacac
    21601 cgtcaggtag gcgctgctgg ccccggccga ggcgaagaag agcaccacgc accagcagac
    21661 ggtcagcgtg gtggcgtcca gcgagccgcg gtggaacagc cacgcggtga ggaagagcag
    21721 gacgccggac agcaggtacg tcccgctgat catgatccgc cggccgacga ggtcgaagag
    21781 cgggctgagc agcaccgcgc cgcacaggtt gccggcggcg atcaccgcga agtagtagcc
    21841 ggtgtggccg gagtcgacgc cgtagaaggt gatgaggatc gtgccgaacc cgaaggtgat
    21901 ggcgttgtag aggaacgcct gcccgatgaa cagggacagg ccgagcgtgg cgcgcctggg
    21961 gtacttcagg aagacggtct tcgcgatcag tccgaagccg atgctccggc gctggtggat
    22021 ggccatctcg cggtcggcgc gcggcagccg ggtccccttc tccgcctcga cctgccgctc
    22081 gacgtcggag acgagctggt cggcctcgtc gccgtagccg tggatgaact gccagcgcgg
    22141 gctctccggc acgtgccggc gcaccagcag gatgaccagg ccgagcacca cgccgagcgc
    22201 gaaggtcagc cgccagccga cgtccttggc gaagacgccg gtgttcagcg ccacgatgga
    22261 cagcagcgaa ccgccgatcg cgccgagcca gtagctgccg ttgatgctca ggtccacccg
    22321 gccgcggtac ttcgacggga tcagctcgtc gatcgcggag ttgatcgccg cgtactcccc
    22381 gccgatgccg aagccggtca ggaagcggaa ggtgaagaac caccacggcg cgaaggacag
    22441 cgcggtcatc gcggtggcgc ccaggtacac cgcgagggtc accatgaaca gcttcctgcg
    22501 gccgaaccgg tccgtcagcc acccgaagaa gagcgcgccg acacacgcgc cggtcacgta
    22561 gagggcggcc gcgagcccgg tgatctgcga ggacgtgatg gacagcccgg agccgggctc
    22621 ggacagccgc ccggcgatgt tgccgacgat gg
//
