LOCUS       NZ_AP018365            23450 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  Streptomyces sp. SN-593 chromosome.
ACCESSION   NZ_AP018365
VERSION     NZ_AP018365.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. SN-593
  ORGANISM  Streptomyces sp. SN-593
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Panthee,S., Kito,N., Hayashi,T., Shimizu,T., Ishikawa,J.,
            Hamamoto,H., Osada,H. and Takahashi,S.
  TITLE     beta-carboline chemical signals induce reveromycin production
            through a LuxR family regulator in Streptomyces sp. SN-593
  JOURNAL   Sci Rep 10 (1), 10230 (2020)
   PUBMED   32576869
  REMARK    DOI:10.1038/s41598-020-66974-y Publication Status: Online-Only
REFERENCE   2
  AUTHORS   Takahashi,S., Toyoda,A., Sekiyama,Y., Takagi,H., Nogawa,T.,
            Uramoto,M., Suzuki,R., Koshino,H., Kumano,T., Panthee,S., Dairi,T.,
            Ishikawa,J., Ikeda,H., Sakaki,Y. and Osada,H.
  TITLE     Reveromycin A biosynthesis uses RevG and RevJ for stereospecific
            spiroacetal formation
  JOURNAL   Nat Chem Biol 7 (7), 461-468 (2011)
   PUBMED   21642985
  REMARK    Publication Status: Online-Only
REFERENCE   3
  AUTHORS   Panthee,S., Takahashi,S., Takagi,H., Nogawa,T., Oowada,E.,
            Uramoto,M. and Osada,H.
  TITLE     Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds
            from Streptomyces reveromyceticus SN-593
  JOURNAL   J. Antibiot. 64, 509-513 (2011)
REFERENCE   4
  AUTHORS   Takahashi,S., Takagi,H., Toyoda,A., Uramoto,M., Nogawa,T., Ueki,M.,
            Sakaki,Y. and Osada,H.
  TITLE     Biochemical characterization of a novel indole prenyltransferase
            from Streptomyces sp. SN-593
  JOURNAL   J Bacteriol 192 (11), 2839-2851 (2010)
   PUBMED   20348259
REFERENCE   5  (bases 1 to 8833490)
  AUTHORS   Takahashi,S., Ueki,M., Toyoda,A., Ishikawa,J., Sakaki,Y. and
            Osada,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2017) Contact:Shunji Takahashi Chemical Biology
            Research Group, RIKEN Center for Sustainable Resource Science
            (CSRS); Hirosawa 2-1, Wako, Saitama 351-0198, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Phrap v. 0.990329
            Genome Coverage                   :: 16x
            Sequencing Technology             :: ABI 3730
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016756395.1-RS_2024_05_21
            Annotation Date                   :: 05/21/2024 03:58:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,420
            CDSs (total)                      :: 7,334
            Genes (coding)                    :: 7,181
            CDSs (with protein)               :: 7,181
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 153
            CDSs (without protein)            :: 153
            Pseudo Genes (ambiguous residues) :: 0 of 153
            Pseudo Genes (frameshifted)       :: 35 of 153
            Pseudo Genes (incomplete)         :: 136 of 153
            Pseudo Genes (internal stop)      :: 8 of 153
            Pseudo Genes (multiple problems)  :: 25 of 153
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:29:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 22671
            Orig. end                         :: 46121
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP018365.1.
            This work was done in collaboration with Shunji Takahashi, Masashi
            Ueki, Atsushi Toyoda, Yoshiyuki Sakaki and Hiroyuki Osada (RIKEN)
            and Jun Ishikawa (National Institute of Infectious Diseases).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23450
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23450
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23450
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13450](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13450)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    389..407
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.73"
                     /tool="antismash"
     misc_feature    complement(467..482)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.9"
                     /tool="antismash"
     CDS             complement(773..949)
                     /gene="allorf_0023444_0023620"
                     /locus_tag="allorf_0023444_0023620"
                     /protein_id="allorf_0023444_0023620"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MATRARGDPGDAGQGDPAESGRARAFLAGPVPERRGDPRGARGPL
                     AGRLPGCGSARPR"
     CDS_motif       complement(863..949)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MATRARGDPGDAGQGDPAESGRARAFLAG"
                     /locus_tag="allorf_0023444_0023620_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(773..862)
                     /prepeptide="core"
                     /locus_tag="allorf_0023444_0023620_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.20"
                     /molecular_weight="2991.4"
                     /monoisotopic_mass="2989.6"
                     /core_sequence="PVPERRGDPRGARGPLAGRLPGCGSARPR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MATRARGDPGDAGQGDPAESGRARAFLAG"
                     /leader_location="[862:949](-)"
     gene            complement(966..2783)
                     /locus_tag="RVR_RS00100"
                     /old_locus_tag="RVR_26"
     CDS             complement(966..2783)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0071704 - organic substance metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719388.1"
                     /locus_tag="RVR_RS00100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_26"
                     /product="cellulase family glycosylhydrolase"
                     /protein_id="WP_272933048.1"
                     /transl_table=11
                     /translation="MLTGAQLAASWTAPLSTAGRYVVDANGDRFKLKAGNWEGAQGTWE
                     GSGAVDDPAQNHAGEPSYGLPLGLDRAPVARILADFHGLGLNSVRLPFSDAMIHDTTPV
                     PDSAVAANPQLRGDTPLQVYDAVVAALTGDGFAVILNDHTTTSRWCCGVDGNERWNSGQ
                     STQQWEADWLFMVDRYRADKRVVGADLRNEVRRDVLDDPNWGSGDAHDEYAAFEEAGNE
                     ILADDPDLLIIMEGINWYGIPLDGLPHGRPMLTPVATVSNTLIASDKLVYSAHFYAYTG
                     PANSGAGSGLGATSDPRYEDFTPAQLASAVDQEALFVTQAGQHFTAPVWVSEFGAAGRG
                     EADPKEQAWFDAFTDILIGDDTDFAVWPLVGWTAADGTPQDNWAALSYDRSGNAISITD
                     PGDWRAADWNALVTAPSVTGPVARPDRWNMLDLDFADEDTSATMLALPDWSSGNRKGVC
                     PDTERLAGLGRGDGRGLCTDSGQPQRSAGAFTVVTDERYVTEGDWASGYSKLQCPDATV
                     AVGYSVHNDAMAALLCAPAAVPPPTTGRDVWFDQGDNRPASGGSTASDWAVGSYKGQCA
                     DDEYVAGVAYTWKWLAGGVPAALLCRPLR"
     gene            3454..6807
                     /locus_tag="RVR_RS00105"
                     /old_locus_tag="RVR_28"
     CDS             3454..6807
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF036578.4"
                     /locus_tag="RVR_RS00105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_28"
                     /product="alpha-L-rhamnosidase"
                     /protein_id="WP_202231808.1"
                     /transl_table=11
                     /translation="MKSHDSDAPDAPRDAGASRRQFLVLGGGTLGALGLSATGLPSASA
                     APAKGTPAASSRTVTPRGLRAAAMTDPVGIDVPRPTLSWELALPAGAAPVAEPVRQKAY
                     QIQVATSSQAFDHGRPDLWDSGRVTGADTFAIPYGGKPVPARTRAYWRVRVWDEHAGAS
                     AWSTPALWETGLLDAEDWTARWIGNSQWEQPYGITAPLTAPQTARYVQITVSDLGRPAS
                     ALDDTVNWKPQLQISEITVLDSARPGVDLARGAAVTANDSLTVPGQWAPEYLTDGKLTS
                     REAPYGYQSTVRGDTDISDDPVTLTLDLGASVSFDSVVVYQRWDAPSQWGMTPDYPRSL
                     TVSVADDPAGPFTLAGTVKKDDKPYPPSSMHQAPAALPLFAKDFSVEGAVDRARLYISA
                     AGIHAASVNGRAATSAVLEPPNTNALVEIPYATYDVTDLLHTGANTVGVEIGNGIWDIF
                     NTLDNPSRYIKATAAFGPPRLIAQLEIRYKGGRTQTVATDSSWLTTLGPTTFSNWYGGE
                     DFDARRVQHGWDRPGADRGSWDKASAAGPPAPGTALVGRTAPPVQIVDVHPAVAVTSPS
                     DGVYVIDFGVNSAGWQQLRMRGPAGTTVKMLPGEKLTAAGAVDQSTTGTPIYDSYVMAG
                     TGEEIWQPRFVYHGFRYVEVQGLPAAPALADAKTLVLRTANAAAGSFTSSDTLLNSIHT
                     IIDRSVQSNMYSVFTDCPHREKLGWLDQTGLALGAATRTYDIEAYGRKLVRDMVQAQAA
                     DGMVPTTAPEIALFAGAYRYDANWGGSVVLVPWALYRAYGDLPTLRSTYPAMKRYLAYL
                     TGLTTGNLLDGGLGDWETVETTTTPTMLVQSYAYRRLAGTLATIAGVLGEKADARRYQA
                     LADAITTAFNAAYFNASGATYATGSQTANALALDAGFVPAAHRDAVLSTLIASVRAAGN
                     HLGTGEVGLPAALRVLADAGRHDVIWDIASQTTYPSYGHMVATGSTSLAESWGGMGTSS
                     SQNHWMLGALEEWFTAGLGGITQTPGSVAFGDLSIAPAVVGDLTSVDSTYRTPQGTVGS
                     SWKRSGTSLALTASVPPNTTATLSVPLAPAGGSHAEVTAPAGAALLRRDTATAVYRIGT
                     GTWRFTARPR"
     gene            complement(6960..7862)
                     /locus_tag="RVR_RS00110"
                     /old_locus_tag="RVR_32"
     CDS             complement(6960..7862)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (13-174). E-value: 9.2e-25.
                     Score: 79.3. Matches aSDomain:
                     nrpspksdomains_RVR_RS00110_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136345.1"
                     /locus_tag="RVR_RS00110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_32"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_202231809.1"
                     /sec_met_domain="ADH_N (E-value: 4.8e-10, bitscore: 38.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPNAVVLSAFGPPEVLRWARVPLPEPAEGQIRIKVAAAGVGPTDL
                     DLRSGRLKAFPLEPDAVLGFEVAGTVDAVGPGVTGTFVGDDVAALLFGLGGYAEYALAS
                     IWTPKPAPVSFVDAAALPSSAEAAAGVLRQLGVTAGETLLLLGGGGSVGVIATQLAVAQ
                     GVKVISAVGARDDALAARLGATPVRYGPGLVAEVRRAGGVQAVFDAAGRGALADAVELA
                     GGPERVITLSDPAAADFGVTLSHPSPDRAPGALAETMAMLADGRLVMRERMTLPMAQAA
                     RAHRLLESGEVRRRIVLTL"
     CDS_motif       complement(7245..7265)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RVR_RS00110_0003"
                     /evalue="9.90E+01"
                     /label="PKSI-ER_m2"
                     /locus_tag="RVR_RS00110"
                     /protein_end="206"
                     /protein_start="199"
                     /score="-3.3"
                     /tool="antismash"
                     /translation="AGGVQAV"
     aSDomain        complement(7341..7823)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RVR_RS00110_PKS_ER.1"
                     /evalue="9.20E-25"
                     /label="RVR_RS00110_PKS_ER.1"
                     /locus_tag="RVR_RS00110"
                     /protein_end="174"
                     /protein_start="13"
                     /score="79.3"
                     /tool="antismash"
                     /translation="EVLRWARVPLPEPAEGQIRIKVAAAGVGPTDLDLRSGRLKAFPLE
                     PDAVLGFEVAGTVDAVGPGVTGTFVGDDVAALLFGLGGYAEYALASIWTPKPAPVSFVD
                     AAALPSSAEAAAGVLRQLGVTAGETLLLLGGGGSVGVIATQLAVAQGVKVISAVGAR"
     CDS_motif       complement(7455..7481)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RVR_RS00110_0002"
                     /evalue="5.80E+01"
                     /label="PKSI-ER_m2"
                     /locus_tag="RVR_RS00110"
                     /protein_end="136"
                     /protein_start="127"
                     /score="-2.3"
                     /tool="antismash"
                     /translation="AAGVLRQLG"
     CDS_motif       complement(7638..7676)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RVR_RS00110_0001"
                     /evalue="4.20E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="RVR_RS00110"
                     /protein_end="75"
                     /protein_start="62"
                     /score="10.2"
                     /tool="antismash"
                     /translation="LGFEVAGTVDAVG"
     gene            complement(8019..8483)
                     /locus_tag="RVR_RS00115"
                     /old_locus_tag="RVR_33"
     CDS             complement(8019..8483)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669847.1"
                     /locus_tag="RVR_RS00115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_33"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_237404479.1"
                     /transl_table=11
                     /translation="MDTAPRWLTPVEERAWRGMMRMHDLVVSEAGRVMQEEFGLSGADY
                     AVLAELSRLRDGRLRILELTKVLGWEKSRVSHHLGRMVKRGLLAREECAEDGRGAYVAV
                     TPEGRAAIEAAAPRHVEDVRRLLLDHLTPGQITMLAEISETVIGKSATDR"
     gene            complement(8548..9297)
                     /locus_tag="RVR_RS00120"
                     /old_locus_tag="RVR_34"
     CDS             complement(8548..9297)
                     /NRPS_PKS="Domain: PKS_KR (7-166). E-value: 1.1e-16. Score:
                     53.2. Matches aSDomain:
                     nrpspksdomains_RVR_RS00120_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669630.1"
                     /locus_tag="RVR_RS00120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_34"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_202231810.1"
                     /sec_met_domain="adh_short (E-value: 2.3e-33, bitscore:
                     114.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 3.9e-36, bitscore:
                     123.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGQLDGRTAVVTGGTSGIGLAAAERFAREGAHVYVTGRRKDSLDR
                     AVAQIGGNVTAVQADSADLADLDRLYATVAEAGHRIDVLFANAGGGAFARLEDVTEEHF
                     EATFGTNVKGTLFTVQKALPLLVDGASVILTGSTAAAVGSEAFGVYGASKAAIRSFART
                     WANELRGRGIRVNTISPGPITTPGLNGLAPDEEQAAQLRETLAAGVPLGRMGRPEEVAS
                     LALFLATAESSFITGTEMYVDGGANQV"
     aSDomain        complement(8800..9276)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RVR_RS00120_PKS_KR.1"
                     /evalue="1.10E-16"
                     /label="RVR_RS00120_PKS_KR.1"
                     /locus_tag="RVR_RS00120"
                     /protein_end="166"
                     /protein_start="7"
                     /score="53.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAVVTGGTSGIGLAAAERFAREGAHVYVTGRRKDSLDRAVAQIGG
                     NVTAVQADSADLADLDRLYATVAEAGHRIDVLFANAGGGAFARLEDVTEEHFEATFGTN
                     VKGTLFTVQKALPLLVDGASVILTGSTAAAVGSEAFGVYGASKAAIRSFARTWAN"
     CDS_motif       complement(9181..9270)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RVR_RS00120_0001"
                     /evalue="1.20E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="RVR_RS00120"
                     /protein_end="39"
                     /protein_start="9"
                     /score="21.1"
                     /tool="antismash"
                     /translation="VVTGGTSGIGLAAAERFAREGAHVYVTGRR"
     gene            complement(9480..9659)
                     /locus_tag="RVR_RS00125"
                     /old_locus_tag="RVR_37"
     CDS             complement(9480..9659)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS00125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_37"
                     /product="hypothetical protein"
                     /protein_id="WP_202231811.1"
                     /transl_table=11
                     /translation="MENDIVRAWKAYAEPGVAGGGPLQALDVQDVVQGGSVVASWQGSF
                     SCCDTTLCSDCSIN"
     CDS_motif       complement(9555..9659)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MENDIVRAWKAYAEPGVAGGGPLQALDVQDVVQGG"
                     /locus_tag="RVR_RS00125_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9480..9554)
                     /prepeptide="core"
                     /locus_tag="RVR_RS00125_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.20"
                     /molecular_weight="2371.6"
                     /monoisotopic_mass="2370.0"
                     /core_sequence="SVVASWQGSFSCCDTTLCSDCSIN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MENDIVRAWKAYAEPGVAGGGPLQALDVQDVVQGG"
                     /leader_location="[9554:9659](-)"
                     /alternative_weights="2389.6"
                     /alternative_weights="2407.6"
                     /alternative_weights="2425.7"
                     /alternative_weights="2443.7"
     gene            complement(9721..9900)
                     /locus_tag="RVR_RS00130"
                     /old_locus_tag="RVR_38"
     CDS             complement(9721..9900)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS00130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RVR_38"
                     /product="hypothetical protein"
                     /protein_id="WP_202231812.1"
                     /transl_table=11
                     /translation="MENDIVRAWKAYAEPGVAVSGPLEALDVRDVVKGGGVIGSWEGTF
                     SCCDTTICAGCTGF"
     CDS_motif       complement(9796..9900)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MENDIVRAWKAYAEPGVAVSGPLEALDVRDVVKGG"
                     /locus_tag="RVR_RS00130_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9721..9795)
                     /prepeptide="core"
                     /locus_tag="RVR_RS00130_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.80"
                     /molecular_weight="2307.6"
                     /monoisotopic_mass="2306.0"
                     /core_sequence="GVIGSWEGTFSCCDTTICAGCTGF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MENDIVRAWKAYAEPGVAVSGPLEALDVRDVVKGG"
                     /leader_location="[9795:9900](-)"
                     /alternative_weights="2325.6"
                     /alternative_weights="2343.6"
     gene            complement(10001..13450)
                     /locus_tag="RVR_RS00135"
                     /old_locus_tag="RVR_40"
     CDS             complement(10001..13450)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="RVR_RS00135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_40"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_202231813.1"
                     /sec_met_domain="DUF4135 (E-value: 2.9e-88, bitscore:
                     295.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.2e-47, bitscore:
                     161.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQQVLGEGVAAKRPLAMPWERRGRAALEGAWWARALRLDERCAA
                     GVPAVDLAEGTDARRLADLRMARWRAAFADLAADTVDRQAAAYGCTPVDLWRLLGEPPE
                     DLARRVPRPGWARDVERVAASAGDGRGEGEGPEPAWGTGWQRDFARILDPFVCEAVRLF
                     HAAVGADIGTEAATGTDIATAATTGTRDRAAEEARRADLPAVVASVRREAARQSVQLAM
                     RVLVMELNVLRVTGRLEGDTPEARFASFVRHFRRPEGLAELLDEYAVLARSLVAAAERV
                     AQVHAEFLRRLAADRPSLAAELFGGTDPGPLAALDLGRGDTHAGGRSAGIATFASGARV
                     AYKPRPAALHRHVAEVVERCNAVLPAGTELRVPAVVDRGDHGWSEFITAAPCPDAPAAA
                     RYFRRQGALLAVLHVLGGVDFHFENLIAAGDRPVPIDLETLLCADLPRPSGSGVHDTDP
                     AAHAYRESVGRVGLLPAVIVGADGQAFDAGGMGGGADAALPYRIAGWAGAGTDTMRLER
                     VTPVLRDAANRPRLDGVELDAVRYAADLLAGYRGCYEALAPSAAGLLAPERFAADPVRV
                     IPRPTHEYSVLLAETTHPDVLREALDREQVYAVLWARGAADPLRARLTRFEVADLWAGD
                     VPLFTTLAGEREVRAADGTPVGELLPESGVDLVRRTLGALGGRHLAEQEWIIAAQLATR
                     ADTGAGPEGRAAERAGVPASPVPAPGGPADLAERALAQADAIADRLSATAYRDGPRVGW
                     LGLDLAEDTRWSVRPLGMDLYNGYGGVALFLAQLAAVTGEERRAAQALAALAPVAGRAR
                     ELLADPDGQDPEGLPGAFTGAGGLAYVLAACGKLLGGTAAADAAALAGPLLEMIRRGLG
                     PEAGHDVISGIAGCLAVAEALAGEADEGAAGEQAGERAGAPGGKAAARAGGLGRAARAL
                     AERCVEVLLAGAVPEDGHLSWPGPDGRALLGFSHGASGIGWALLRHARRSGDQEAAAAA
                     RRAFAFERAGFDPRTGNWPDRRYDPPGNLFAWCHGAPGVGLARAAAADPGDEDARADLR
                     RALAGTAAFRRQGNDSLCHGESGNLELFAAARDLGWERGRLEWRERAAALVARIERNGP
                     VCGTPGGIATPGLMTGLSGVGHGLLRVAAPDRVPPVLLLPPV"
     misc_feature    complement(13840..13855)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.51"
                     /tool="antismash"
     gene            13977..14744
                     /locus_tag="RVR_RS00140"
                     /old_locus_tag="RVR_41"
     CDS             13977..14744
                     /NRPS_PKS="Domain: Thioesterase (26-249). E-value: 6e-39.
                     Score: 126.7. Matches aSDomain:
                     nrpspksdomains_RVR_RS00140_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013166.4"
                     /locus_tag="RVR_RS00140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_41"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_202231814.1"
                     /sec_met_domain="Thioesterase (E-value: 6.5e-34, bitscore:
                     116.8, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.1e-09, bitscore:
                     37.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGPEMVESGNPWVLTFGEPPVPPGIRLFCLPYAGGSPHSFHTWA
                     EALDPRIEVVAVALPGQGHRISEKPHEDWTALTADAFAALEPLLEQPHAFYGHSFGARL
                     GYELARLAADRYPGATRRLFVGGCRSPQWPQDRPYMHEQPYDGFVASLRKLGGTPTVVL
                     DHPALMRSLFPSLQAQIRLAELWEDVHGAPTTVPVTAMYGQEDPIDGEAAMRGWAAFGG
                     PGSEVLAMAGGHFFLDADPASVLSVIDARLSGV"
     aSDomain        14055..14723
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RVR_RS00140_Thioesterase.1"
                     /evalue="6.00E-39"
                     /label="RVR_RS00140_Thioesterase.1"
                     /locus_tag="RVR_RS00140"
                     /protein_end="249"
                     /protein_start="26"
                     /score="126.7"
                     /tool="antismash"
                     /translation="RLFCLPYAGGSPHSFHTWAEALDPRIEVVAVALPGQGHRISEKPH
                     EDWTALTADAFAALEPLLEQPHAFYGHSFGARLGYELARLAADRYPGATRRLFVGGCRS
                     PQWPQDRPYMHEQPYDGFVASLRKLGGTPTVVLDHPALMRSLFPSLQAQIRLAELWEDV
                     HGAPTTVPVTAMYGQEDPIDGEAAMRGWAAFGGPGSEVLAMAGGHFFLDADPASVLSVI
                     D"
     CDS_motif       14250..14309
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RVR_RS00140_0001"
                     /evalue="3.70E-05"
                     /label="NRPS-te1"
                     /locus_tag="RVR_RS00140"
                     /protein_end="111"
                     /protein_start="91"
                     /score="16.3"
                     /tool="antismash"
                     /translation="PHAFYGHSFGARLGYELARL"
     gene            complement(14882..15271)
                     /locus_tag="RVR_RS00145"
     CDS             complement(14882..15271)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RVR_RS00145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_237404480.1"
                     /transl_table=11
                     /translation="MAETPRALVRRPRKRAGMTRFQPAERAGSGERTTGRIANDKPFDH
                     PARAAGARRPTRACEAGTHGRQAGSGKAGSQAQVQGETQVEGGLRGGAAGGGRLALLAA
                     AALAAAAASRPLPRLRNRQRRGRDD"
     misc_feature    complement(15303..15321)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 20.7"
                     /tool="antismash"
     gene            complement(15313..15993)
                     /locus_tag="RVR_RS00150"
                     /old_locus_tag="RVR_43"
     CDS             complement(15313..15993)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="RVR_RS00150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_43"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_202231816.1"
                     /transl_table=11
                     /translation="MAGRPVDHERRAELLDAVVDHTVEHGFNDLSWRPVAAALGVSPTT
                     LVHRFGSKEQMLQAVLGRLRERILTATATATATATATGKATAPAGPGGLEAAARAVWQR
                     TSDPGQGPEFRLFFAVYGRALQDPEQFADFLGHVVADWSEVLREAQGPDADPALAARTA
                     TLVIATIRGLLLDLLATGDRARVQDAAEAFLATLRPAGGASGDPATEPPPRAGTPATGD
                     TASG"
     CDS             16006..16164
                     /gene="allorf_0038677_0038835"
                     /locus_tag="allorf_0038677_0038835"
                     /protein_id="allorf_0038677_0038835"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MCHGPPVRGRRLSRTPAVPAAASRTPVPAAPRCRVPVSATGGHRC
                     AGRAVTW"
     CDS_motif       16006..16068
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MCHGPPVRGRRLSRTPAVPAA"
                     /locus_tag="allorf_0038677_0038835_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       16069..16164
                     /prepeptide="core"
                     /locus_tag="allorf_0038677_0038835_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.20"
                     /molecular_weight="3098.6"
                     /monoisotopic_mass="3096.7"
                     /core_sequence="ASRTPVPAAPRCRVPVSATGGHRCAGRAVTW"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MCHGPPVRGRRLSRTPAVPAA"
                     /leader_location="[16005:16068](+)"
                     /alternative_weights="3116.6"
                     /alternative_weights="3134.6"
                     /alternative_weights="3152.6"
     misc_feature    16153..16168
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            complement(16165..17151)
                     /locus_tag="RVR_RS00155"
                     /old_locus_tag="RVR_45"
     CDS             complement(16165..17151)
                     /NRPS_PKS="Domain: PKS_ER (15-325). E-value: 3e-50. Score:
                     163.0. Matches aSDomain:
                     nrpspksdomains_RVR_RS00155_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573521.1"
                     /locus_tag="RVR_RS00155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_45"
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_202231817.1"
                     /sec_met_domain="ADH_N (E-value: 1.2e-08, bitscore: 33.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 7.3e-17, bitscore:
                     60.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRVVIFDETGGPEVLHVVDEPAGEPGPGEVRVRIEAFAVNRLDA
                     LVRAGTAPMPARLPHARLGCEGTGTIDAVGPGVEGLAEGDAVLITAVPDMTAGGTYAET
                     VVLPAARVIERPAGLGATEAAALWVAYSTAYGALVEKAGTRPGDHVLITAASGTVGLAA
                     LQIARQIGAVPLAVSRHAAKRDALLAAGAAAVVATDEEDVVEATRRHTGGAGADVVLDS
                     VMGPGLAALANATRRFTGTLVTVGWLDPRPAPYPGNAITTHRYMSFEHTLDPVAVRRIA
                     AFLRAGLRTGALHPAVDRVFALEDVVAAHRYLEEGQQGPGKIVVTAG"
     aSDomain        complement(16177..17106)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RVR_RS00155_PKS_ER.1"
                     /evalue="3.00E-50"
                     /label="RVR_RS00155_PKS_ER.1"
                     /locus_tag="RVR_RS00155"
                     /protein_end="325"
                     /protein_start="15"
                     /score="163.0"
                     /tool="antismash"
                     /translation="LHVVDEPAGEPGPGEVRVRIEAFAVNRLDALVRAGTAPMPARLPH
                     ARLGCEGTGTIDAVGPGVEGLAEGDAVLITAVPDMTAGGTYAETVVLPAARVIERPAGL
                     GATEAAALWVAYSTAYGALVEKAGTRPGDHVLITAASGTVGLAALQIARQIGAVPLAVS
                     RHAAKRDALLAAGAAAVVATDEEDVVEATRRHTGGAGADVVLDSVMGPGLAALANATRR
                     FTGTLVTVGWLDPRPAPYPGNAITTHRYMSFEHTLDPVAVRRIAAFLRAGLRTGALHPA
                     VDRVFALEDVVAAHRYLEEGQQGPGKIVV"
     CDS_motif       complement(16651..16713)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RVR_RS00155_0002"
                     /evalue="3.30E-07"
                     /label="PKSI-ER_m5"
                     /locus_tag="RVR_RS00155"
                     /protein_end="167"
                     /protein_start="146"
                     /score="22.8"
                     /tool="antismash"
                     /translation="GDHVLITAASGTVGLAALQIA"
     CDS_motif       complement(16738..16782)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RVR_RS00155_0001"
                     /evalue="4.90E-02"
                     /label="PKSI-ER_m4"
                     /locus_tag="RVR_RS00155"
                     /protein_end="138"
                     /protein_start="123"
                     /score="7.4"
                     /tool="antismash"
                     /translation="AAALWVAYSTAYGAL"
     gene            complement(17239..17673)
                     /locus_tag="RVR_RS00160"
                     /old_locus_tag="RVR_46"
     CDS             complement(17239..17673)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324492.1"
                     /locus_tag="RVR_RS00160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_46"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_202231818.1"
                     /transl_table=11
                     /translation="MRVGELAARTGVSVRALRYYEEQHLLTAERSASGQRHYPDGAVDR
                     VRLIQELYAAGLSSRTIVELMPCVVEGRATPELLDRLAAERERVDRRVTDLLRTRDRLD
                     AVIGGASGNLRTGVSCRARSAAGAPPAEASSAGTSPDRAV"
     gene            17817..18758
                     /locus_tag="RVR_RS00165"
                     /old_locus_tag="RVR_47"
     CDS             17817..18758
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467618.1"
                     /locus_tag="RVR_RS00165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_47"
                     /product="chlorophyllase"
                     /protein_id="WP_202231819.1"
                     /transl_table=11
                     /translation="MPRYETTGLTGPSPVAAVSVGPVVLPAPDRGTDLHVRVSAPVTGT
                     GLPVVLFAHGFGSDLDGYAPLAAHWASRGFVVVQPTHLDAKRLDLAPDDPRRPNLWLHR
                     VRDMRRVLDELGTLEAALPGLAGRVDRSRVVAAGHSFGGQTAGLLVGQRVTDPLTGRVQ
                     DLSDPRVTASIQLATAGRGGDDLTPYAREHVPWLVGQDFSAITAPGLVVAGDRDELPLS
                     TRGPAWTAEPYTLGPGARSLLTVYGGRHFLGGISGYGAAETTDEDPDRLALVQHVTLAY
                     LRHVTGTGDGDWDAARAELAGGSHPLGRLESK"
     gene            complement(18781..20541)
                     /locus_tag="RVR_RS00170"
                     /old_locus_tag="RVR_48"
     CDS             complement(18781..20541)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018560919.1"
                     /locus_tag="RVR_RS00170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_48"
                     /product="beta-galactosidase"
                     /protein_id="WP_202231820.1"
                     /transl_table=11
                     /translation="MPQELRIEPDGFRLDGEPFRIISGGLHYFRVHPEQWADRLRKARL
                     MGLNTIDTYVPWNLHQPRPGAELDLAGMLDLPRFLELAAAEGLHVLLRPGPYICAEWEG
                     GGLPSWLLARQDVRLRSNDAGYMAAVEDYFRALLPVVAPHLASNGGPVLAVQVENEYGA
                     YGDDTGHLRRIADLLRDGGVDVPLFTCDQPGDLARGALPGVLATVNLGSRAAAGLAALR
                     AHQPQGPLMVAEFWNGWFDRWGGVHVVRDAADAAAELDAVLASGASVNLYMFHGGTNFG
                     FTNGANDKHTYRPTVTSYDYDAPLDEAGDPTPKYAAFREVIARHAPVPDEAAPPPAKKL
                     SVLGVTLDRTAPLLDGAPLLGDAVRGPRPLSMEELGQDFGFVLYGTTLAEPGPAVLSLQ
                     DVRDRAQVFVDGQPAGVLEREGHEPAVAFTVPRAGARLEVLVENQGRVNYGQALHDRKG
                     LLGEARLDGAVLRDWTSRPLPLTAASLERLEFTAADRPPVGPAFHRGVFDVETPADTYL
                     DLTGWTKGNAWINGFPLGRFWSRGPQATLYVPAPVLRAGANEVVVLELHTAARTTVALR
                     DTPDLGPEEE"
     gene            complement(20680..21672)
                     /locus_tag="RVR_RS00175"
                     /old_locus_tag="RVR_51"
     CDS             complement(20680..21672)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527322.1"
                     /locus_tag="RVR_RS00175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_51"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_202238269.1"
                     /transl_table=11
                     /translation="MADVARLAGVSAQTVSRVSNGAPGVVDATRQQVLAAMKELGYRPN
                     SAARALKSGRFHTIGVILFNISTTGNTRTLEAIATSAAAEGYAITLLPVAAATQDSVRG
                     AFTRMGELAVDGIIMLMEAHLLDASTVTLPPRALAVVADSNAGDRYRVVDTDQVGGAQA
                     AVQHLLQLGHDTVWHVAGPADSYSAERRVEAWRSALQSRRREVPEPLRGDWTADSGYRA
                     GLQLAEEPDCTAVFVANDQMALGLLRALHEHGLRVPEDISVVGFDDLPEAGSFLPPLTT
                     VHQDFSEVGRRCVEELLAQIRNDQEATGTTLVPTRLVTRASTAPPRSTR"
     gene            complement(21927..23270)
                     /locus_tag="RVR_RS00180"
                     /old_locus_tag="RVR_52"
     CDS             complement(21927..23270)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044303.1"
                     /locus_tag="RVR_RS00180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RVR_52"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_202231821.1"
                     /transl_table=11
                     /translation="MRTSSLSRFAGMVAALCAASVGLAACGSSGGSGSSGDKTSASDVQ
                     SALAKGGSITVWAWEPTLKQVVTDFEKKYPKVHVNLVNAGTGNDQYTALQNAVEAGKGV
                     PDVAQIEYYALGQFALSKSLTDLSGYGAKDLKSTYSTGPWNSVNVDGGVYALPMDSGPM
                     ALFYNKKVFDKYKLPVPTTWEQYLDDARKLHKADPKAYIANDTGDAGETTSLIWQAGGK
                     PYSVDGSNVSIDFSKDSGTATYTKVWQQLISEHLLAPVTGWTDQWYKGLGDGTIATLAT
                     GAWMPANFASGVKDAAGDWRVAPLPQWQAGANASAENGGSSLAVMKASSKKDLAYAFLQ
                     YANQGAGVQTRISNGAFPATTADLDSASFQDQKFAYFGGQQANKVFAQSAKDVLPGWSY
                     LPYQVYANSVFNDSVGKAYTSGTPLTSALEAWQNKSISYGKEQGFSVK"
ORIGIN
        1 ctcccagtcc tccatcagcc gcgcggccag gccgtgccgc tccgccagtg cgacgagcgt
       61 ctccgcgcgg tagtagaagt cctcccgcag cacctggtgc tcggcgccca gcgtgcggtc
      121 gaaggtgaag tcgaagtagc ccccgggcgc caggacccgc cccacgtgcg caaggcactc
      181 gtcgatcacc ggcaggggcg aatgcgagaa cacgctgtgc gcgtgcacca ccgtgaagaa
      241 gcccgacggc aggaagtcga aggtcaggtc gttcgcgagc gtcaggtgcg ggagcttgtc
      301 ctggaggccg tagcggacca ccgtgccctt cgcctccacc aggatgtccg gcgagatgtc
      361 gatgccgtgg tagtggccgg gctccagata ctcgatgaac cgccaacccg cccgcaggtt
      421 cccgcacccg atctccagca tccggtctcc cggcaccagc ccgtgcccga ccaggtagtc
      481 gaactgcatc cggcccaggg ccagccagcg gtccatcgtc gcgctcccca cggcgtcctg
      541 cgggctgcgc gcggtgtccg aggccatgac cgcgcggtag tacgccacat ggtcgcggtg
      601 ccgggcacgc agccaggcat cacgcgccga gcgccgcaca tagggccgga tccgctccgg
      661 atggcgcagc gcgtagccga tcttgtgggc gagtgacgcg cggttggcca gcagccgcga
      721 cgtggtccgg tccgccatga cgcctccgct tcctgtccgg tcccccacat cgtcaccgcg
      781 gacgtgccga cccgcacccc ggaagccgcc ctgcgagtgg tccccgagcg ccgcgggggt
      841 caccgcggcg ctcggggacc gggcccgcga ggaaggcgcg ggcccgcccg gactcggccg
      901 gatcaccctg gccggcatcc cccgggtcac cacgcgcccg ggtcgccaca cacccggtgg
      961 cccggtcagc gcaaggggcg gcacagcagg gccgccggga cgcctcccgc caaccacttc
     1021 caggtgtagg cgacgcccgc gacgtactcg tcgtcggcgc actggccctt gtaggagccc
     1081 accgcccagt cgctggccgt ggaaccgccg gaggcgggtc ggttgtcgcc ctggtcgaac
     1141 cagacgtccc gtcccgtcgt gggcgggggg accgcggcgg gcgcgcacag cagcgccgcc
     1201 atggcgtcgt tgtgcacgct gtaccccacg gcgacggtgg cgtccgggca ctggagcttg
     1261 ctgtagccgg acgcccagtc cccctcggtg acgtaccgct cgtcggtcac gacggtgaac
     1321 gcgcccgccg accgctgcgg ctgcccggaa tccgtgcaca ggccgcggcc gtcaccgcgg
     1381 ccgagcccgg ccagacgctc ggtgtcgggg cacaccccct tgcggttccc gctggaccag
     1441 tccggcagcg cgagcatggt ggccgaggtg tcctcgtccg cgaagtccag gtcgagcatg
     1501 ttccaccggt cgggtcgcgc gaccgggccc gtcacgctcg gggcggtgac cagcgcgttc
     1561 cagtccgccg cgcgccagtc gccggggtcg gtgatgctga tcgcgttccc ggaccggtcg
     1621 tacgacagcg ccgcccagtt gtcctgcggc gtgccgtcgg ccgccgtcca ccccaccagg
     1681 ggccacaccg cgaagtccgt gtcgtcgccg atcaggatgt cggtgaacgc gtcgaaccac
     1741 gcctgctcct tcggatccgc ctcgccgcgg cccgccgcgc cgaactcgct cacccacacc
     1801 ggcgcggtga agtgctgccc ggcctgggtg acgaacagcg cctcctggtc caccgcggag
     1861 gcgagctggg ccggggtgaa gtcctcgtac ctcgggtcgc tggtggcccc gagcccggag
     1921 ccggccccgc tgttggccgg tccggtgtag gcgtagaagt gcgccgagta caccagcttg
     1981 tccgacgcga tcagggtgtt ggacaccgtc gccaccgggg tgagcatcgg ccggccgtgc
     2041 ggcagcccgt cgagcgggat gccgtaccag ttgatgccct ccatgatgat cagcaggtcc
     2101 gggtcgtcgg ccaggatctc gttgcccgcc tcctcgaacg cggcgtactc gtcgtgcgcg
     2161 tcgcccgagc cccagttggg atcgtcgagc acgtcccggc gcacctcgtt gcgcaggtcc
     2221 gcgcccacca cccgcttgtc cgcccggtag cggtccacca tgaacagcca gtccgcctcc
     2281 cactgctgag tgctctgccc gctgttccac cgctcgttcc cgtccacacc gcagcaccaa
     2341 cgggacgtcg tggtgtggtc gttgaggatc accgcgaagc cgtcaccggt cagcgccgcg
     2401 accaccgcgt cgtagacctg gagcggagtg tcgccacgca gttgcgggtt ggccgcgacc
     2461 gcggaatccg gcacgggcgt cgtgtcgtgg atcatcgcgt cggagaacgg caaccggacg
     2521 ctgttcaggc ccaggccgtg gaagtcggcc agaatccgtg cgaccggcgc ccggtccaac
     2581 cccagcggca ggccgtacga cggctccccc gcatggttct gcgcgggatc gtcgacagcg
     2641 ccgctgccct cccacgtgcc ctgcgccccc tcccagttgc ccgctttcag cttgaagcgg
     2701 tccccgttcg catcgacgac gtaacggccc gcggtactca gcggagcggt ccacgacgcc
     2761 gcgagctgcg caccggtcaa cacagtcggc gccgccgacc ccgccgcttc cggccccgct
     2821 cccgccggtg tcctcgcagc cgaggcggcc gaagcggcgg aagcggcgga agcggccacg
     2881 cttccggacg tccccggcgc cgcgccgatc aacgtccccg cgaccgccgc cacggccacc
     2941 gccacccgcg cggcccggcg cgagcgccca ggtgccggga cccacgtgat ccactccatc
     3001 gaagcgcccc ttccagcaac ggatgcggta ccccacaggt tcgggcaccc ggccggcgaa
     3061 caccacaacc gcgcacgcac gcgaggcccc cacccgtcac ttttcagccc cgcggcacgc
     3121 accggagccg ccctcgttcc acccccgccc cccgcaccac cccggccggc aacgcccggg
     3181 caaacagggc cgccccgccg gaaacccggg gccgtcgcac accccggcag caatcggaac
     3241 gtttcagaca ccccgccata tgccaccccc ggccgacccg caccggcccc gcgggggtgg
     3301 gctccctcgt ccaacctgtg cggccgaaga cggtgacacg cacgggattt agccgtaagt
     3361 tgccctcgca agcccctccc cccgcatccg cctcgcgcgg tggccgaccg cacacgcgag
     3421 atttgaaacg attcatttat ggagaggaac atcatgaaaa gccacgattc cgacgccccc
     3481 gacgcccccc gcgacgcggg cgccagccgc cgccagttcc tggtgctcgg cggcggaacg
     3541 ctcggcgccc tgggcctgag cgcgacgggc ctgcccagcg cgtccgccgc gcccgcgaaa
     3601 gggacaccgg cggcctcctc gcgcaccgtc accccccgcg ggctgcgcgc cgccgcgatg
     3661 accgacccgg tcggcatcga cgtgccccgc cccaccctga gctgggaact cgccctcccc
     3721 gcgggggccg cgccggtcgc cgagccggtg cgccagaagg cgtaccagat ccaagtggcc
     3781 accagcagcc aggcgttcga ccacggccgc cccgacctgt gggacagcgg acgcgtcacc
     3841 ggcgcggaca ccttcgcgat cccctacggc ggaaagccgg tccccgcccg gacccgggcg
     3901 tactggaggg tgcgggtctg ggacgagcac gcaggcgcgt ccgcctggag cacgcccgcg
     3961 ttgtgggaga ccggcctgct cgacgccgag gactggaccg cccggtggat cggcaacagc
     4021 cagtgggagc agccctacgg catcaccgcg ccgctgacgg ctccgcagac cgcacgctac
     4081 gtgcagatca ccgtcagcga cctgggccgt cccgcgtccg cgctggacga caccgtgaac
     4141 tggaagccgc agcttcagat ctccgagatc acggtgctcg actccgcccg gcccggggtc
     4201 gacctcgccc gcggtgccgc ggtgaccgcc aacgactcgc tgaccgtccc cggccagtgg
     4261 gcccccgaat acctcaccga cggcaagctg acctcccgtg aggcgccgta cggctaccag
     4321 agcacggtgc gcggcgacac cgacatctcc gacgacccgg tcaccctcac cctcgacctg
     4381 ggcgcctccg tgtccttcga ctcggtcgtg gtctaccagc gctgggacgc gccgagccag
     4441 tggggcatga ccccggacta cccccggtcg ctgaccgtgt cggtcgccga cgacccggcc
     4501 gggcccttca ccctggccgg cacggtgaag aaggacgaca agccgtaccc gccgtccagc
     4561 atgcaccagg cacccgccgc cctgccgctg ttcgccaagg acttctccgt cgagggcgcc
     4621 gtggaccgcg cccggctcta catatccgcc gccggcatcc acgccgcgag tgtcaacggc
     4681 cgcgccgcca ccagcgcggt gctcgaaccg cccaacacca acgcgctggt cgagatcccc
     4741 tacgccacct acgacgtcac cgatctgctg cacaccggcg ccaacaccgt gggcgtcgag
     4801 atcggcaacg gcatctggga catcttcaac accctcgaca accccagccg ctacatcaag
     4861 gccaccgccg ccttcggacc gccgcggctc atcgcccaac tggagatccg ctacaagggc
     4921 ggccgcaccc agaccgtcgc caccgacagc tcctggctga ccacgctcgg accgaccacg
     4981 ttcagcaact ggtacggcgg cgaggacttc gacgcccgcc gcgtgcagca cggatgggac
     5041 cggcccggcg ccgaccgcgg ctcctgggac aaggcgtcgg ccgccggccc gcccgccccg
     5101 ggcaccgcgc tcgtcggccg gaccgcaccg cccgtgcaga tcgtggacgt ccaccccgcc
     5161 gtcgcggtca cctcgccctc cgacggcgtg tacgtgatcg acttcggcgt caacagcgcg
     5221 ggctggcagc aactgcggat gcgcggcccg gccggcacca ccgtgaagat gctgcccggg
     5281 gagaagctga ccgccgccgg cgccgtcgac cagtccacca ccggcacgcc catctacgac
     5341 agctacgtga tggccggcac cggggaggag atctggcagc cccgcttcgt ctaccacggc
     5401 ttccgctacg tggaggtgca gggcctgccc gccgcccccg cgctcgccga cgccaagacg
     5461 ctcgtgctgc gcaccgccaa cgccgcggcc ggctccttca cctcctccga caccctgctc
     5521 aacagcatcc acaccatcat cgaccggtcc gtgcagagca acatgtactc ggtgttcacc
     5581 gactgcccgc accgcgagaa gctcggctgg ctggaccaga ccggactcgc cctgggcgcg
     5641 gccacccgca cgtacgacat cgaggcgtac ggccgcaagc tcgtgcgcga catggtccag
     5701 gcgcaggcgg ccgacggcat ggtcccgacc accgcgccgg agatcgccct gttcgccggc
     5761 gcgtaccgct acgacgcgaa ctggggcggc tccgtcgtcc tcgtgccctg ggcgctgtac
     5821 cgcgcctacg gcgacctgcc caccctgcgc tccacctacc cggccatgaa gcgctacctc
     5881 gcctacctga ccggcctgac caccggcaac ctcctcgacg gcggactcgg cgactgggag
     5941 accgtcgaga ccaccaccac cccgaccatg ctggtccaga gctacgccta ccggcggctg
     6001 gccggcaccc tggccacgat cgccggggtg ctcggcgaga aggccgacgc ccggcgctac
     6061 caggccctgg ccgacgcgat caccaccgcg ttcaacgccg cctacttcaa cgcgtccggc
     6121 gccacctacg cgaccggctc gcagaccgcc aacgccctcg ccctggacgc cgggttcgtg
     6181 ccggccgccc accgggacgc cgtgctgtcg acgctgatcg cgtccgtccg cgccgcgggc
     6241 aaccacctcg ggaccggcga ggtcggcctg cccgcggccc tgcgcgtcct ggccgacgcg
     6301 ggacgccacg acgtcatctg ggacatcgcc agccagacga cctaccccag ctacggacac
     6361 atggtggcca ccggctccac ctcgctggcc gagtcctggg gcggcatggg caccagttcc
     6421 tcccagaacc actggatgct cggcgcgctc gaggaatggt tcaccgcggg tctgggcggc
     6481 atcacccaga cccccggctc cgtcgccttc ggcgacctgt ccatcgcccc ggccgtcgtc
     6541 ggcgacctca cctccgtgga ttccacctac cgcacaccgc agggcaccgt gggcagctcc
     6601 tggaagcgct cgggcacctc cctcgcgctg accgcctccg tcccgcccaa caccaccgcc
     6661 accctcagcg tccccctcgc cccggcggga ggatcccacg ccgaggtgac agcgcccgcc
     6721 ggcgccgcgc tcctgcggcg cgacaccgcc accgccgtct accggatcgg caccggcacg
     6781 tggaggttca ccgcccggcc gcgctgaccg gagggcccgc gccatccgcg gcgcccacga
     6841 cgcaggaccg cgcggcgggc cccgggaccg atccgcacgc accggggcgc gccgccgtcc
     6901 atgacggccg ggcgggccgc agggccgcag ggccgcaggg ccgcagggcc gcagggccgt
     6961 cagagcgtga ggacgatccg ccggcgcacc tcgccgctct ccaggaggcg gtgggcgcgc
     7021 gcggcctgcg ccatggggag ggtcatgcgc tcgcgcatca ccagccggcc gtcggcgagc
     7081 atcgccatgg tctcggcgag ggctcccggc gcacggtccg gggaggggtg ggagagggtg
     7141 acgccgaagt cggccgcggc ggggtcggac agggtgatca cgcgttccgg tcccccggcc
     7201 agttcgaccg cgtccgccag cgctccccgc ccggccgcgt cgaagacggc ctggacaccg
     7261 cccgcccgcc ggacctccgc caccagcccg ggcccgtagc ggaccggggt ggcacccaac
     7321 cgggcggcca gcgcgtcgtc ccgggcaccg accgcgctga tcaccttcac cccctgggcg
     7381 acggcgagtt gggtggcgat gacgcccacc gaaccgccgc cgcccaggag cagcagcgtc
     7441 tcccccgccg tgacgccgag ctgccgcagc accccggcgg ccgcctccgc ggaactcggc
     7501 agggccgcgg cgtcgacgaa ggacaccggg gcgggcttgg gcgtccagat cgaggccagc
     7561 gcgtattccg cgtagccgcc caggccgaag agcagcgccg cgacatcgtc accgacgaag
     7621 gtgcccgtca cacccgggcc cacggcgtcg accgtccccg cgacctcgaa acccagcacg
     7681 gcgtccggct ccagcgggaa cgccttcaga cggccggacc gcaggtcgag atcggtcgga
     7741 ccgaccccgg ccgcggccac cttgatcctg atctggccct cggccggctc cggcagcggc
     7801 acccgcgccc agcgcaggac ctccggcggc ccgaacgcgg acagcaccac ggcattcggc
     7861 atgactcctc gctttcccat gcacagttca cggtccccca cggccgaggg cttcacgact
     7921 ccacgcggca ccggtacgac gtccgaaccc gctttggatg acgcgtcatc tatatacggc
     7981 cggggaactc cgacccgccg cgaccgcggc ggcccgggtc agcggtccgt ggcgctcttt
     8041 ccgatgaccg tctcggatat ctcggccagc atcgtgatct ggcccggggt gaggtggtcc
     8101 agcagcagcc gccggacgtc ctccacgtgc cggggcgcgg ccgcctctat cgccgcacgg
     8161 ccttcgggag tgaccgccac gtacgccccg cgtccgtcct ccgcgcactc ctcgcgggcc
     8221 agcaggccgc gcttgaccat ccgcccgagg tggtgggaca cccggctctt ctcccacccg
     8281 agcaccttgg tgagttcgag gatgcgcagc cggccgtcgc ggaggcggct caactcggcc
     8341 agcaccgcgt agtcggcgcc cgacagcccg aactcctcct gcatgacccg gccggcctcg
     8401 ctcaccacca gatcgtgcat ccgcatcatg ccccgccacg cgcgctcctc gaccggggtg
     8461 agccaacgcg gtgccgtgtc catgcacgca tcgtacgaga ggggggccgc cggcacgccc
     8521 gcgcccttcg ccccgccgcg cgggcgctca gacctggttg gcgccaccgt cgacgtacat
     8581 ctcggtgccg gtgatgaagc tggactccgc cgtggcgagg aagagcgcga ggctcgcgac
     8641 ctcctcgggc cgccccatac ggcccagcgg gaccccggcg gcgagcgtct cgcgcagttg
     8701 ggcggcctgc tcctcgtcgg gggccaggcc gttgagcccg ggggtcgtga tcggtccggg
     8761 ggagatcgtg ttgacgcgga tgccgcggcc gcgcagctcg ttcgcccagg tccgggcgaa
     8821 ggagcggatg gccgccttgg acgcgccgta gacgccgaac gcctcgctgc cgaccgcggc
     8881 cgcggtcgag ccggtcagga tcaccgacgc cccgtccacc aggagcggaa gcgccttctg
     8941 gacggtgaac agcgtcccct tgacgttcgt gccgaacgtc gcctcgaagt gctcctcggt
     9001 cacgtcctcc agcctggcga acgcgccgcc gccggcgttg gcgaacagca cgtcgatacg
     9061 gtgcccggcc tcggcgacgg tggcgtagag ccggtcgagg tccgcgaggt cggcgctgtc
     9121 ggcctggacg gccgtcacgt tcccgccgat ctgcgcgacc gcccggtcca gggagtcctt
     9181 gcggcgcccc gtgacgtaga cgtgcgcgcc ctcccgggcg aagcgctccg ccgcggcgag
     9241 cccgatcccg ctcgtaccgc cggtgaccac ggccgtcctg ccgtccaact gtcccatgac
     9301 acgctccttg ctgcttccgg atggccggac ggccaccctg cggttcaatc ttcaaccacc
     9361 ataacccaac tggatgacat gtcaaccata cgtcgatgag acgcccggcg cgtccaccgg
     9421 ggaggacgcg tacgggcccc gtcccgtcac cggggcgggg cccgcgagcc gccggacgat
     9481 cagttgatcg agcagtccga gcacagcgtg gtgtcgcagc agctgaacga gccctgccag
     9541 ctcgccacga cgctcccgcc ctggacgacg tcctggacgt cgagcgcctg aagcggaccg
     9601 ccgccggcca cgccgggctc ggcgtacgcc ttccaggcgc gcacgatgtc gttctccatg
     9661 ggtgtcacct cccttctcgt cagtcgcgcg gggggcggct cacagcggcc gccccgacgg
     9721 tcagaagccg gtgcagcccg cgcagatggt ggtgtcgcag cagctgaacg tgccctccca
     9781 gctcccgatg acgccaccgc ccttgacgac gtcccggacg tccagcgcct ccagcggacc
     9841 gctcacggcc acacccggct cggcgtacgc cttccaggcg cgcacgatgt cgttctccac
     9901 agctctcact tcccttctcg tcggtaacca ccgctccccg cccgtgccgg acggggagcc
     9961 ccgcggaggg cgcacccgcg cgccctccgc ggcccgccgg tcacaccggc gggagcagga
    10021 ggaccggggg gacccggtcg ggagcggcca cgcgcagcag cccgtggccg actccggaca
    10081 ggccggtcat gaggccggga gtcgcgatgc cgcccggggt cccgcagacc gggccgttcc
    10141 gctcgatgcg ggcgaccagc gcggcggccc gctcgcgcca ttccaggcgg ccccgctccc
    10201 agcccaggtc gcgcgccgcg gcgaacagtt cgaggttgcc cgactcgccg tggcacaggc
    10261 tgtcgttgcc ctgcctcctg aaggcggccg tgccggccag cgcgcgccgc aggtccgccc
    10321 gcgcgtcctc gtcgcccggg tcggcggcgg ccgcccgcgc caggcccacg cccggcgcgc
    10381 cgtggcacca cgcgaacagg ttccccggcg ggtcgtagcg gcggtcgggc cagttgcccg
    10441 tgcgcgggtc gaagcccgcg cgctcgaacg cgaaggcgcg ccgcgctgcg gcggccgcct
    10501 cctggtcgcc gctgcgccgg gcgtgccgga gcagcgccca gccgatgccg gatgcgccgt
    10561 gcgagaaacc cagcagggcg cggccgtccg ggcccggcca ggacaggtgg ccgtcctcgg
    10621 gaacggcgcc ggccagcagc acctcgacgc accgctcagc gagcgcgcgg gcggcgcgcc
    10681 cgaggccgcc cgcccgcgcg gcggccttcc cccccggcgc cccggcccgc tccccggcct
    10741 gctcccccgc cgcgccctcg tccgcctcac cggccagcgc ctcggccacc gcgaggcagc
    10801 cggcgatgcc gctgatgacg tcgtgtcccg cctccgggcc cagcccgcgc cggatcatct
    10861 ccagcagggg acccgccaga gccgcggcgt ccgccgccgc cgtgccgccg agcagtttcc
    10921 cgcacgccgc caggacgtag gcgaggccgc cggctccggt gaaggcgccg ggcagtccct
    10981 cggggtcctg cccgtcgggg tccgccagca gttcccgcgc ccggcccgcc acgggcgcca
    11041 gcgcggctag ggcctgcgcc gcgcgccgct cctcaccggt gaccgcggcg agctgggcca
    11101 ggaacagcgc gaccccgccg tacccgttgt agaggtccat gccgagcggg cgcaccgacc
    11161 agcgggtgtc ttccgccagg tccagcccca gccagcccac ccgggggccg tcgcggtagg
    11221 ccgtcgccga cagccggtcc gcgatggcgt ccgcctgggc cagcgcccgc tccgccaggt
    11281 ccgccggtcc ccctggcgcc ggcacggggg acgcggggac cccggcccgt tcggcggccc
    11341 tcccctcggg tcccgccccg gtgtcggcgc gggtcgccaa ctgggccgcg atgatccact
    11401 cctgctcggc caggtggcgg ccgcccaggg cgccgagggt acggcggacc aggtccaccc
    11461 cggactccgg cagcagttcc cccaccgggg tgccgtccgc cgcccggacc tcgcgctccc
    11521 cggccagcgt cgtgaagagc gggacgtcgc cggcccacag gtcggccacc tcgaaccggg
    11581 tcaggcgcgc gcggagcggg tcggcggcgc ccctggccca cagcaccgcg tacacctgct
    11641 cgcggtccag tgcctcccgc agcacgtcgg gatgggtggt ctcggcgagc agcaccgagt
    11701 actcgtgggt ggggcgcggg atcacccgca cggggtcggc ggcgaaccgc tccggcgcga
    11761 ggagtccggc cgccgacggg gccagcgcct cgtagcagcc gcggtagccc gcgagcaggt
    11821 cggcggcgta gcgcaccgcg tccagttcca caccgtccag ccgggggcgg ttcgccgcgt
    11881 cgcgcaggac cggcgtgacc cgctccaggc gcatggtgtc cgtgccggcg cccgcccatc
    11941 ccgcgatccg gtacggcagg gcggcgtcgg cgccgcctcc catcccgccc gcgtcgaacg
    12001 cctgcccgtc cgcgcccacg atcaccgccg gcagcagccc cacccggccc accgactcgc
    12061 ggtacgcgtg cgccgcggga tcggtgtcgt ggaccccgct gccggacggg cgcggcaggt
    12121 cggcgcacag cagcgtctcc aggtcgatcg gtaccggccg gtcccccgcc gcgatcaggt
    12181 tctcgaagtg gaagtcgacg ccgcccagga cgtgcagcac cgccagcagc gcgccctgcc
    12241 gccggaagta ccgcgccgcc gccggggcgt ccgggcacgg cgccgccgtg atgaactcgc
    12301 tccagccgtg gtccccgcgg tccacgacgg ccggcacccg cagttccgtc cccgccggca
    12361 gcacggcgtt gcaccgctcc accacctcgg ccacgtgccg gtgcagggcg gcggggcgcg
    12421 gcttgtacgc gacgcgcgcg cccgacgcga aggtggcgat ccccgcggac cggccgccgg
    12481 cgtgggtgtc cccccgtccg aggtcgaggg cggccagcgg gcccgggtcc gttccgccga
    12541 acagctccgc ggcgagcgac ggacggtcgg cggcgagccg ccggaggaac tcggcgtgca
    12601 cctgcgcgac ccgttccgcg gcggcgacca gcgaccgcgc cagcaccgcg tactcgtcca
    12661 gcagttcggc gagtccctcg gggcggcgga agtggcggac gaacgacgcg aaccgcgctt
    12721 cgggcgtgtc gccctccagc cggcccgtca cccgcaggac gttcagctcc atgacgagga
    12781 cccgcatcgc caactggacc gactgccgtg ccgcctcgcg ccgtaccgac gcgacgaccg
    12841 cggggaggtc cgcgcggcgc gcctcctcgg cggcacggtc gcgggtgccg gtggtggcgg
    12901 cggtggcgat gtccgtgccg gtggcggctt cggtgccgat gtccgcgccg accgcggcgt
    12961 ggaacaggcg tacggcctca cacacgaacg ggtccaggat ccgggcgaag tcccgctgcc
    13021 agcccgtccc ccaggcgggt tccggcccct cgccctcgcc ccggccgtct cccgcggagg
    13081 cggccacccg ctccacgtcc cgcgcccacc cgggccgggg gacccgccgt gccaggtcct
    13141 ccggcggttc ccccagcagc cgccacaggt ccaccggcgt gcagccgtac gcggcggcct
    13201 ggcggtccac cgtgtcggcg gccaggtcgg cgaaggccgc gcgccagcgc gccatccgca
    13261 ggtccgccag ccgtcgggcg tccgtgccct cggccaggtc caccgcgggg acaccggccg
    13321 cgcagcgctc gtccaggcgc agcgcccgcg cccaccacgc gccttccagg gccgcgcgcc
    13381 cccgccgctc ccagggcatc gccagcgggc gcttcgcggc cacgccctca cccagcacct
    13441 gctgcgtcac cgccgcaacc tccctcaccc tccggtgcgg ccggtgaggc cggtccgccg
    13501 accggatacg agacggtccg ggcaccaggc caggcacccg cctgattgga acccggcagg
    13561 gcacccgacg gcatgggtgc tggccaccca catttgccgc cggccgggcg gcgcggcggc
    13621 gcgggacggt ggggcggcgc agggacggct cggcggcgca gggcgatggg gcggcgcggg
    13681 ccgtccgccc gcccgtgagc ggaggtgacg cctcgtcagg gcggttcaac gcaggccggg
    13741 ccgggagccg tcggcacacc tggcgcggcc gggaccggcc gaacgacgcg gggcgcgggg
    13801 cgggcgggcg cgagcgccgg ttcccgcgcg gatgacggcg cttcgctccc ggcgatgcta
    13861 ctgatcgtcc ggtcccggca acggtacggt gaggactcgc tgctgccgga cgacctgtcc
    13921 gccgagagct gcgggagatc gccgagggcg tcctccgcga cacaaccgtg gactatgtgg
    13981 aaggtccgga gatggtggag tccggcaacc cctgggtgct gacgttcggg gagccgcccg
    14041 tgcccccggg catccggctg ttctgcctgc cctacgcggg cggcagcccg cactccttcc
    14101 acacgtgggc ggaggcgctg gacccgcgca ttgaggtcgt cgcggtcgcg ctgcccggcc
    14161 agggccaccg gatcagcgag aagccgcacg aggactggac ggctctcacc gccgacgcct
    14221 tcgccgcgct cgaaccgctc ctggagcagc cgcacgcctt ctacgggcac agcttcggcg
    14281 cgcggctcgg ttacgagctg gcccggcttg cggccgaccg gtatccgggc gccaccaggc
    14341 ggctgttcgt cggcgggtgc cgcagcccgc agtggccgca ggaccgcccc tacatgcacg
    14401 agcagcccta cgacgggttc gtggcgtcgc tgcggaagct gggcggcacg ccgaccgtcg
    14461 tcctggacca ccctgccctg atgcggtcgc tcttcccgtc cctccaggcc cagatccggc
    14521 tcgccgagct gtgggaggac gtgcacgggg cgcccacgac ggttcccgtg accgcgatgt
    14581 acgggcagga ggacccgatc gacggcgagg ccgccatgcg cggttgggcc gccttcggcg
    14641 gtccgggaag cgaggtgctg gccatggccg gcgggcactt cttcctggac gccgatcccg
    14701 cgagcgtgct gtcggtgatc gacgcgcggc tgagcggggt gtgacggccg cggtcgccgc
    14761 cgcgctcagt cgggggtgcg agccggtggc atcgggcttg ctcggccgac gtgacggccg
    14821 ccgtcgtccg acccgccgcg ccggccgccg gtggacggcc cctcgccgcg ggaggcgcgg
    14881 atcagtcgtc gcggccgcgg cgctgacggt tcctcaggcg cggcagcggg cgcgaggcgg
    14941 ccgcggcggc cagcgcggcc gcggccagca gggccaggcg cccgccaccg gcagcaccgc
    15001 cccggagacc gccctcgacc tgagtctcac cctggacctg agcttgagac cctgccttgc
    15061 cgctgcccgc ctggcggcca tgggtccccg cctcgcacgc gcgcgtcggt cgtcgagcac
    15121 cggcagcacg agcagggtgg tcgaacggct tgtcgttcgc gatccggccg gtcgtccgct
    15181 cgcccgaccc ggcgcgctcg gcgggctgga accgcgtcat ccccgcccgc ttgcgcggcc
    15241 gacgcaccag agcccggggg gtctccgcca ccgcgtcgcc cctcgccctt ccgggtgacc
    15301 ggaacggcgg gcctacccgg acgccgtgtc acctgtggcg ggtgtgccgg cgcggggcgg
    15361 gggttcggtt gccgggtcgc cggacgcgcc gccggcgggg cgcagggtcg ccaggaacgc
    15421 ctccgcggcg tcctggaccc tcgcccggtc gccggtggcg agcaggtcga gcagcaggcc
    15481 gcggatcgtg gcgatgacga gggtggcggt gcgcgccgca agtgccgggt cggcgtccgg
    15541 gccctgtgcc tcccgcagga cctcgctcca gtcggccacg acgtggccga ggaagtccgc
    15601 gaactgctcc gggtcctgga gggcgcgtcc gtagaccgcg aagaacagcc ggaactcggg
    15661 gccctggccg gggtcggagg tccgctgcca gaccgcgcgc gcggcggcct ccaggccgcc
    15721 cggcccggcg ggggcggtgg ccttgccggt agcggtagcg gtagcggtag cggtagcggt
    15781 agcggtgagg atccgctcgc gcagccggcc caggaccgcc tggagcatct gctccttgga
    15841 gccgaagcgg tggaccaggg tggtcggcga gaccccgagg gcggccgcga ccggccgcca
    15901 ggacaggtcg ttgaacccgt gctccaccgt gtggtccacg accgcgtcga gcagttcggc
    15961 ccgccgctcg tggtccacgg gacgccccgc catcgccacc tccatgtgtg tcacggcccg
    16021 ccggtgcgcg gccgccggct ctcccggacg ccggccgtcc cggccgccgc ttcccggacg
    16081 ccggtgccgg ccgcaccccg gtgccgggta ccagtctccg ccaccggcgg ccaccggtgc
    16141 gccgggcgtg cggtcacctg gtgatcaccc ggcggtcacc acgatcttgc cggggccctg
    16201 ctgcccctcc tcgaggtagc ggtgggcggc cacgacgtcc tccagcgcga acacccggtc
    16261 cacggccggg tgcagcgccc cggtacgcag accggcgcgc aggaacgcgg cgatgcggcg
    16321 taccgcgacc gggtcgaggg tgtgctcgaa gctcatgtac cggtgggtgg tgatggcgtt
    16381 gccggggtag ggcgcgggcc gcgggtcgag ccagccgacg gtgaccaggg tgccggtgaa
    16441 gcgcctggtg gcgttggcga gggcggcgag gccggggccc atgacggagt cgaggacgac
    16501 gtcggcgccc gcgccgccgg tgtgccggcg ggtggcctcg acgacgtcct cctcgtcggt
    16561 ggcgacgacg gcggccgcgc cggcggccag cagcgcgtcc ctcttcgccg cgtggcggct
    16621 gacggccagc gggacggccc cgatctgccg ggcgatctgg agggcggcca ggcccaccgt
    16681 gccggacgcg gcggtgatca ggacgtggtc gcccggccgg gtcccggcct tctccacgag
    16741 cgcgccgtag gcggtggagt acgccaccca cagcgcggcc gcctcggtgg cgcccaggcc
    16801 cgcgggccgc tcgatcaccc tggcggcggg gagcacgacg gtctcggcgt aggtgccgcc
    16861 cgcggtcatg tcggggacgg cggtgatcag gaccgcgtcg ccctcggcga gtccctcgac
    16921 gccagggccg accgcgtcga tcgtgccggt gccctcgcag cccaggcggg cgtgcggcag
    16981 ccgggccggc atcggggcgg tcccggcgcg caccagcgcg tcgagccggt tgaccgcgaa
    17041 cgcctcgatc cgcacgcgca cctcgccggg tccgggttcg ccggccggtt cgtccacgac
    17101 gtgcaggacc tcgggtccgc cggtctcgtc gaagatgacg actcgtgaca tgggtgtgct
    17161 cctcactggg gacgggcgcg cgcctcgcga cgcgccgtcg gcgaccgcct ccattctttg
    17221 tacggtcgtt caattaagtc aaacggcccg gtcgggggat gtcccggcgg aggatgcctc
    17281 ggcagggggt gccccggcgg cggaccgcgc gcggcaggag acgccggtgc gcaggttccc
    17341 ggacgcgccg ccgatcaccg cgtcgagccg gtcccgggtg cgcagcaggt cggtgacgcg
    17401 ccggtcgacc cgctcgcgct cggccgcgag gcggtcaagc agttcgggcg tggcgcgccc
    17461 ctcgaccacg cacggcatga gttccacgat ggtcctgctg gacagcccgg cggcgtacaa
    17521 ctcctggatc aggcggaccc ggtcgaccgc accgtccggg tagtggcgct gcccgctggc
    17581 gctgcgctcg gcggtgagca ggtgctgttc ctcgtagtag cgcagcgccc ggacgctgac
    17641 cccggtccgg gcggcgagtt ctccgacgcg catctcttct cctgtcggcg gggtgcggcg
    17701 gtccgccgca ggacgggggc cgcggcatct tgcccctgac gtcaacgtca ggttttagcg
    17761 tagccacgcc ccgccgcatt ccgcacgcgc gggaccccga ggagagaagc gcgcccatgc
    17821 cccgctacga gacgaccggt ctgaccggcc cctcccccgt cgccgccgtg tcggtcggcc
    17881 ccgtcgtact gccggcgccg gaccgcggca ccgacctgca cgtgcgcgtc agcgcaccgg
    17941 tcaccggcac cggcctgccg gtcgtgctgt tcgcgcacgg cttcggctcg gacctcgacg
    18001 gctacgcgcc gctggccgcc cactgggcct cgcgcggatt cgtggtcgtc cagcccaccc
    18061 acctggacgc gaagcgcctc gacctcgccc cggacgaccc gcgccgcccc aacctgtggc
    18121 tgcaccgcgt gcgggacatg cgccgcgtcc tggacgaact cggcaccctg gaggcggcgc
    18181 tgcccggcct ggccgggcgg gtggaccgga gccgggtggt ggcggccggg cactccttcg
    18241 gcggtcagac cgccggcctc ctcgtcggtc agcgcgtcac cgacccgctg accggacggg
    18301 ttcaggacct gtccgacccg cgcgtcacgg cgagcatcca gttggccacc gcgggccggg
    18361 gcggcgacga cctgacgccg tacgcccgcg agcacgtgcc ctggctggtc ggccaggact
    18421 tctcggcgat caccgcgccg gggctggtgg tcgccggcga ccgggacgag ttgccgctgt
    18481 ccacccgggg cccggcctgg accgccgagc cgtacaccct cggccccggc gcgaggagcc
    18541 tcctgacggt gtacggcggc cggcacttcc tcggcggcat ctccggctac ggcgcggccg
    18601 agaccaccga cgaggacccg gaccgcctcg cccttgtcca gcacgtcacc ctggcctacc
    18661 ttcgccatgt gacgggcacc ggcgacggcg actgggacgc ggcgcgggcc gagctggccg
    18721 gcggttccca tccgctgggc cggctggagt ccaagtgacc gcggcctcgg cccgcccgcc
    18781 tcactcctcc tcggggccga ggtcgggcgt gtcgcgcagc gccaccgtgg tccgggcggc
    18841 ggtgtgcagt tccagcacga cgacctcgtt ggcacccgcg cgcaggaccg gcgccggcac
    18901 gtagagggtg gcctgcgggc cgcgggacca gaagcggccg agcgggaacc cgttgatcca
    18961 ggcgttgccc ttggtccagc cggtcaggtc gaggtaggtg tcggccgggg tctccacgtc
    19021 gaacacgccg cggtggaagg ccgggccgac gggggggcgg tcggccgcgg tgaactccag
    19081 ccgttccagg ctcgccgcgg tgagcggcag cgggcggctg gtccagtcgc gcagtacggc
    19141 gccgtccagc cgcgcctcgc cgagcaggcc cttgcggtcg tgcagcgcct ggccgtagtt
    19201 gacgcggccc tggttctcca ccaggacctc caggcgggcg ccggcgcgcg gcaccgtgaa
    19261 ggccaccgcc ggctcgtgtc cctcgcgctc cagcacaccg gccggctgcc cgtcgacgaa
    19321 cacctgggcg cggtcgcgca cgtcctggag ggagagcacc gccggtcccg gctcggcgag
    19381 cgtcgtcccg tagagcacga acccgaagtc ctggccgagt tcctccatgg acagcgggcg
    19441 cgggccgcgg acggcgtcgc cgagcagggg cgcgccgtcc agcagcgggg cggtgcggtc
    19501 cagggtgacg cccaggacgc tcagcttctt cgcgggcggc ggcgcggcct cgtccggcac
    19561 gggcgcgtga cgggcgatca cctcgcggaa ggccgcgtac ttcggggtgg ggtcgccggc
    19621 ctcgtcgagc ggcgcgtcgt agtcgtacga ggtgacggtg ggccggtagg tgtgcttgtc
    19681 gttggcgccg ttggtgaagc cgaagttggt gccgccgtgg aacatgtaga ggttcaccga
    19741 ggcgccggag gccaggacgg cgtcgagttc ggcggccgcg tcggcggcgt cgcgcaccac
    19801 gtggacgccg ccccagcggt cgaaccagcc gttccagaac tcggcgacca tcagcggccc
    19861 ctgcggctgg tgcgcgcgca gggcggcgag gccggcggcg gcgcggctgc cgaggttgac
    19921 ggtcgcgagc acgccgggca gggcgccgcg ggcgaggtcg ccgggctggt cgcaggtgaa
    19981 caggggcacg tccacgccgc cgtcccggag caggtcggcg atccgccgca ggtgaccggt
    20041 gtcgtcgccg taggcgccgt actcgttctc gacctggacg gccagcaccg ggccgccgtt
    20101 gctcgccagg tgcggggcga ccaccggcag cagggcccgg aagtagtcct cgacggcggc
    20161 catgtagccg gcgtcgttgc tgcgcagccg gacgtcctgc cgcgccagca gccaggacgg
    20221 cagcccgccg ccctcccact ccgcgcagat gtacgggccc gggcgcagca gcacgtgcag
    20281 gccctcggcc gcggcgagtt cgaggaaccg gggcaggtcg agcatgccgg ccaggtccag
    20341 ttcggcgccg gggcgcggct ggtgcaggtt ccagggcacg taggtgtcga tggtgttcag
    20401 gcccatcagg cgggccttgc gcagccggtc ggcccactgc tcggggtgga cccggaagta
    20461 gtgcaggccg ccggagatga tgcggaacgg ttcgccgtcg agccggaaac cgtcgggttc
    20521 gatccgcagt tcctggggca tggggtcctg ctccttccgg ggagcgtcgt cgaagcaagg
    20581 ggatggttgc gcaaccatcg gtgtgcgcgg gtcggtccgg gcgcgccgaa gggcccggcg
    20641 cgcaccgggg gtccggtgtc ggtcggccgc gggtgcggct cagcgcgtgc tgcgcggagg
    20701 ggcggtgctg gcgcgggtga ccagccgggt gggcaccagc gtggtgccgg tcgcctcctg
    20761 gtcgttgcgt atctgcgcca gcagctcttc cacgcagcgc cgtccgacct cggagaagtc
    20821 ctggtggacg gtggtgagcg ggggcaggaa ggagccggcc tcgggcaggt cgtcgaaccc
    20881 caccacgctg atgtcctccg ggacccgcag cccgtgctcg tgcagggccc gcaggaggcc
    20941 cagcgccatc tggtcgttgg cgacgaagac ggcggtgcag tcgggttcct cggcgagctg
    21001 gagtccggcc cggtagccgg agtcggccgt ccagtcgccg cgcagcggtt cgggcacctc
    21061 gcggcgccgg gactggagcg ccgagcgcca cgcctcgacc cgccgctccg cggagtagga
    21121 gtccgcgggg ccggcgacgt gccagaccgt gtcgtgtccg agctggagca ggtgctggac
    21181 ggccgcctgc gcgcccccga cctggtcggt gtcgaccacg cggtagcggt cgccggcgtt
    21241 ggagtcggcg acgacggcca gggctcgcgg cggcagcgtc accgtggagg cgtccagcag
    21301 gtgggcctcc atcagcatga tgatgccgtc gacggcgagt tctcccatcc gggtgaacgc
    21361 gccgcgcacg ctgtcctggg tcgccgcggc gaccggcagc agcgtgatgg cgtacccctc
    21421 ggccgcggcg gaggtcgcga tggcctccag cgtgcgggtg ttgccggtgg tggagatgtt
    21481 gaacaggatg acgccgatcg tgtggaaccg gccgctcttg agggcccggg cggcggagtt
    21541 gggccggtag cccagctcct tcatcgcggc cagcacctgc tggcgggtgg cgtcgaccac
    21601 gccgggcgcg ccgttggaca cccgggagac ggtctgcgcg gagacccccg cgagccgggc
    21661 cacgtccgcc atcgacgcgc tgcggcgccg ccgctgggcg gtggccggcc cgggccggag
    21721 ccgagcggtg tcgccctgct cggctgtttc gctgtcggtc acttgctgcc tgcaccttcg
    21781 cccgctggcc gggctcttac gatggccgat gccacagtct acggatggcg ccgtcgccgg
    21841 gccggggcgg cttccccggc gccgggtccg gctgccgcgg ggaccgcccg tcaggcgggc
    21901 cccgcggcac ccttgctgag cgggcgtcac ttgacgctga agccctgttc cttgccgtag
    21961 gagatcgact tgttctgcca tgcctccagc gcggaggtca gcggcgtgcc cgaggtgtac
    22021 gccttgccga cggagtcgtt gaagacggag ttggcgtaga cctggtaggg caggtaggac
    22081 cagcccggca gcacgtcctt ggcggactgg gcgaagacct tgttggcctg ctggccgccg
    22141 aagtaggcga acttctggtc ctggaaggac gcggagtcca ggtccgcggt ggtggccggg
    22201 aacgcgccgt tggagatccg ggtctgcacg ccggcgccct ggttcgcgta ctgcaggaag
    22261 gcgtaggcga ggtccttctt gctgctggcc ttcatcaccg cgagcgagct gccgccgttc
    22321 tcggcgctgg cgttcgcgcc ggcctgccac tgcggcagcg gggccacccg ccagtcgccg
    22381 gccgcgtcct tcacgccgga ggcgaagttg gccggcatcc acgcgccggt ggccagggtg
    22441 gcgatggtgc cgtcgcccag gcccttgtac cactggtcgg tccagccggt caccggcgcg
    22501 agcaggtgct cggagatgag ctgctgccac accttggtgt aggtggcggt gccggagtcc
    22561 ttcgagaagt cgatcgagac gttgctgccg tcgaccgagt agggcttgcc gccggcctgc
    22621 cagatgaggc tggtggtctc gccggcgtca ccggtgtcgt tggcgatgta cgccttcggg
    22681 tcggccttgt gcagcttgcg ggcgtcgtcg aggtactgct cccaggtggt gggcaccggc
    22741 aacttgtact tgtcgaagac cttcttgttg tagaacagcg ccatcggacc ggagtccatc
    22801 ggcagcgcgt agacgccgcc gtcgacgttg acggagttcc acggcccggt ggagtaggtg
    22861 ctcttgaggt ccttggcgcc gtagccgctc aggtcggtga gggacttcga cagcgcgaac
    22921 tggccgagcg cgtagtactc gatctgcgcg acgtcaggga cgcccttgcc ggcctcgacg
    22981 gcgttctgca gcgccgtgta ctggtcgttg ccggtgccgg cgttgaccag gttgacgtgc
    23041 accttcgggt acttcttctc gaagtcggtg acgacctgct tcaaggtggg ctcccacgcc
    23101 cagacggtga tcgaccctcc cttggccagc gcggactgga cgtcggaggc cgaggtcttg
    23161 tcgccggacg agccggaacc accggacgag ccgcaggcgg ccagaccgac cgaggcggcg
    23221 cagagcgcgg ccaccatccc cgcgaagcgg gagagggacg aggttctcat tgatgtcact
    23281 ccgttgtgcg tgatgagggt gctgaagcgt ggaacgtggt ggtccggagc ggcccgggac
    23341 gggtcactcc ttgacgctcc cggcggccag gccggactgc cagtaccgct ggaggaggag
    23401 gaaggccgcg atgagcggga tgatcgtcag cagcgagccg gtgatcacca
//
