GCF_016726365.1 - 3 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP068102.1 (Rothia aeria)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	terpene-precursor	598,350	619,483
Region 2	lanthipeptide-class-ii,lassopeptide	1,159,091	1,200,946
Region 3	NRPS	2,454,467	2,498,723	High	enterobactin	NRPS:Type I

NZ_CP068102.1 - Region 1 - terpene-precursor

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Location: 598,350 - 619,483 nt. (total: 21,134 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

I6I94_RS02565: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acyltransferase

I6I94_RS02550: acyltransferase

smcogs: SMCOG1141: acyltransferase

Ligases: ligase synthetase

I6I94_RS02530: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

I6I94_RS02560: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000597.4	0.39	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0001910.4	0.39	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000595.3	0.39	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000664.5	0.39	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000597.4	0.39	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0001910.4	0.39	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000595.3	0.39	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000664.5	0.39	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

I6I94_RS02530: PT_FPPS_like

Domain 1 (54 - 372): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.04 out of 18.57

Confidence: medium

Additional weak hits (7):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.83 out of 27.78

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 21.44 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.59 out of 36.54

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.44 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.65 out of 39.62

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.87 out of 32.93

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.03 out of 23.43

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis

NZ_CP068102.1 - Region 2 - lanthipeptide-class-ii,lassopeptide

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Location: 1,159,091 - 1,200,946 nt. (total: 41,856 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

I6I94_RS04875: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: acetyltransferase

I6I94_RS04960: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase

I6I94_RS04920: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: cyclase

I6I94_RS04835: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

I6I94_RS04845: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: ligase

I6I94_RS04935: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001555.4	0.32	ribosomal	colicin V	Escherichia coli chi7122
BGC0002698.2	0.31	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000517.4	0.30	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000575.5	0.30	ribosomal	lariatin	Rhodococcus jostii
BGC0000504.5	0.29	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001889.2	0.29	ribosomal	fusilassin	Thermobifida fusca YX
BGC0001210.5	0.29	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000589.5	0.29	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0000588.5	0.29	ribosomal	microcin L	Escherichia coli
BGC0001229.4	0.28	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.62	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001176.4	0.61	ribosomal	streptomonomicin	Streptomonospora alba
BGC0002110.3	0.56	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0002698.2	0.54	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002150.2	0.54	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.54	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0001634.3	0.51	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0001549.3	0.51	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for I6I94_RS04835

I6I94_RS04840

Leader:

MPKDITLLEEISDQELGQVNGG

Core:

GSHGGGYYSSVGGGSYGGGYCGGGCGGYGYGFGFWGGSFS

Core with dehydrations:

GDhaHGGGYYDhaDhaVGGGDhaYGGGYCysGGGCysGGYGYGFGFWGGDhaFDha

antiSMASH-DB 4.0 matches for I6I94_RS04840

100.0%

NZ_CP068102.1and 7 others:

NZ_CP068102.1 Lanthipeptides: I6I94_RS04840_lanthipeptideNZ_CP079819.1 Lanthipeptides: LPB401_RS00100_lanthipeptideNZ_CP079819.1 Lanthipeptides: LPB401_RS00100_lanthipeptideNZ_KI518028.1 Lanthipeptides: HMPREF0742_RS01820_lanthipeptideNZ_KI518028.1 Lanthipeptides: HMPREF0742_RS01820_lanthipeptideNZ_LR134479.1 Lanthipeptides: EL250_RS01330_lanthipeptideNZ_LR134479.1 Lanthipeptides: EL250_RS01330_lanthipeptide

Lanthipeptides: I6I94_RS04840_lanthipeptide

GSHGGGYYSSVGGGSYGGGYCGGGCGGYGYGFGFWGGSFS

18.2%

NC_014643.1and 16 others:

NC_014643.1 Lanthipeptides: HMPREF0733_RS05060_lanthipeptideNZ_CP054018.1 Lanthipeptides: FOC60_RS00340_lanthipeptideNZ_CP079201.1 Lanthipeptides: LPB409_RS01335_lanthipeptideNZ_JVLW01000024.1 Lanthipeptides: ADD47_RS04725_lanthipeptideNZ_JVXR01000038.1 Lanthipeptides: ADK06_RS05015_lanthipeptideNZ_KV793075.1 Lanthipeptides: HMPREF3164_RS06945_lanthipeptideNZ_KV795763.1 Lanthipeptides: HMPREF2554_RS09025_lanthipeptideNZ_KV795763.1 Lanthipeptides: HMPREF2554_RS09025_lanthipeptideNZ_KV797630.1 Lanthipeptides: HMPREF2609_RS06005_lanthipeptideNZ_KV797887.1 Lanthipeptides: HMPREF2625_RS00515_lanthipeptideNZ_KV802313.1 Lanthipeptides: HMPREF2756_RS06530_lanthipeptideNZ_KV804818.1 Lanthipeptides: HMPREF2804_RS09475_lanthipeptideNZ_KV804818.1 Lanthipeptides: HMPREF2804_RS09475_lanthipeptideNZ_KV815277.1 Lanthipeptides: HMPREF2958_RS01940_lanthipeptideNZ_KV817389.1 Lanthipeptides: HMPREF2981_RS04625_lanthipeptideNZ_KV820076.1 Lanthipeptides: HMPREF3016_RS03055_lanthipeptide

Lanthipeptides: HMPREF0733_RS05060_lanthipeptide

YGFGFWGGS

+GFGFWGGS

FGFGFWGGS

MIBiG 4.0 matches for I6I94_RS04840

15.0%

BGC0002322.3 (CEJ66604.1):

Lasso peptide: citrocin

YCGGGCGGYG

+ GGG G YG

FIGGGVGRYG

I6I94_RS04850

Leader:

MAKDTMFMEELTDQELEQVNGG

Core:

CYSSCGYYGGSYGGSYGGSYCGSGSSYYGGGYYYAAVGYGYSC

Core with dehydrations:

CysYDhaDhaCysGYYGGDhaYGGDhaYGGDhaYCysGDhaGDhaDhaYYGGGYYYAAVGYGYDhaCys

antiSMASH-DB 4.0 matches for I6I94_RS04850

100.0%

NZ_CP068102.1and 1 other:

NZ_CP068102.1 Lanthipeptides: I6I94_RS04850_lanthipeptide

Lanthipeptides: I6I94_RS04850_lanthipeptide

CYSSCGYYGGSYGGSYGGSYCGSGSSYYGGGYYYAAVGYGYSC

87.5%

NZ_CP079819.1and 1 other:

NZ_CP079819.1 Lanthipeptides: LPB401_RS00090_lanthipeptide

Lanthipeptides: LPB401_RS00090_lanthipeptide

CYSSCGYYGGSYGGSYGGSYCGSGSSYY-----GGGYYYAAVGYGYSC

CYSSCGYYGGSYGGSYGGSYCGS SSYY GGGYYYAAVGYGYSC

CYSSCGYYGGSYGGSYGGSYCGSSSSYYGGSYSGGGYYYAAVGYGYSC

19.1%

NZ_QFWW01000059.1:

Lanthipeptides: allorf_187545_187781_lanthipeptide

GGSYGGSYGGSYCGSG-SSYYGGGYYYAAVGYGYSC

GG + GG++ +G S++ GGG + AA+G S

GGDWRAVVGGAWRVAGCSAWPGGGDWRAALGEARSA

with 2 more sequence matches

18.0%

NC_015953.1:

Lanthipeptides: allorf_2485079_2485273_lanthipeptide

SYGGSYCGSGSSYYGGGYYYAAVG

GG CG+ YG G A G

KLGGPACGTLRRRYGAGIAPARRG

17.9%

NZ_CP025394.1and 1 other:

NZ_CP025394.1 Lanthipeptides: CFP65_RS07275_lanthipeptide

Lanthipeptides: CFP65_RS07275_lanthipeptide

SSCGYYGGSYGGSYGGSYCGS

S G GS GS+ GS+ GS

SQPGSRPGSRPGSWTGSWTGS

MIBiG 4.0 matches for I6I94_RS04850

14.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

CGYYGGSYGGSYGGSYC

C +Y S G+YC

CAWYNISCRLGNKGAYC

9.3%

BGC0000581.6 (AAD28494.1):

Lasso peptide: microcin J25

CGSGSSYYG

G+ S+YG

IGTPISFYG

allorf_1166508_1166591

Leader:

MVNNLYGG

Core:

GYFCSLVVSSCSLVDTHPA

Core with dehydrations:

GYFCysDhaLVVDhaDhaCysDhaLVDDhbHPA

antiSMASH-DB 4.0 matches for allorf_1166508_1166591

100.0%

NZ_CP068102.1and 3 others:

NZ_CP068102.1 Lanthipeptides: allorf_1166508_1166591_lanthipeptideNZ_CP079819.1 Lanthipeptides: allorf_0023758_0023841_lanthipeptideNZ_CP079819.1 Lanthipeptides: allorf_0023758_0023841_lanthipeptide

Lanthipeptides: allorf_1166508_1166591_lanthipeptide

GYFCSLVVSSCSLVDTHPA

MIBiG 4.0 matches for allorf_1166508_1166591

5.9%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

CSLVVSSC

C++ ++C

CNMKTATC

allorf_1176509_1176580

Leader:

MVENRDLASS

Core:

SPKYSAIKNCSRK

Core with dehydrations:

DhaPKYDhaAIKNCysDhaRK

antiSMASH-DB 4.0 matches for allorf_1176509_1176580

100.0%

NZ_CP068102.1and 1 other:

NZ_CP068102.1 Lanthipeptides: allorf_1176509_1176580_lanthipeptide

Lanthipeptides: allorf_1176509_1176580_lanthipeptide

SPKYSAIKNCSRK

92.3%

NZ_CP079819.1and 3 others:

NZ_CP079819.1 Lanthipeptides: allorf_0013756_0013827_lanthipeptideNZ_KI518028.1 Lanthipeptides: allorf_295646_295717_lanthipeptideNZ_KI518028.1 Lanthipeptides: allorf_295646_295717_lanthipeptide

Lanthipeptides: allorf_0013756_0013827_lanthipeptide

SPKYSAIKNCSRK

SPK+SAIKNCSRK

SPKHSAIKNCSRK

84.6%

NZ_LR134479.1and 1 other:

NZ_LR134479.1 Lanthipeptides: allorf_0270410_0270481_lanthipeptide

Lanthipeptides: allorf_0270410_0270481_lanthipeptide

SPKYSAIKNCSRK

SPK+S IKNCSRK

SPKHSTIKNCSRK

with 1 more sequence matches

21.4%

NZ_RYYV01000004.1:

Lanthipeptides: allorf_108405_108521_lanthipeptide

PKYSAIKNCSRK

P++ NCSRK

PRWKISNNCSRK

allorf_1176709_1176894

Leader:

MLCALIALYYG

Core:

HHITKWCDIKWKLRICESVKLFLSHNRSPISAFGSSRCYPFFASSIEHPQ

Core with dehydrations:

HHIDhbKWCysDIKWKLRICysEDhaVKLFLDhaHNRDhaPIDhaAFGDhaDhaRCysYPFFADhaDhaIEHPQ

antiSMASH-DB 4.0 matches for allorf_1176709_1176894

100.0%

NZ_CP068102.1and 1 other:

NZ_CP068102.1 Lanthipeptides: allorf_1176709_1176894_lanthipeptide

Lanthipeptides: allorf_1176709_1176894_lanthipeptide

HHITKWCDIKWKLRICESVKLFLSHNRSPISAFGSSRCYPFFASSIEHPQ

98.0%

NZ_KI518028.1and 3 others:

NZ_KI518028.1 Lanthipeptides: allorf_295332_295517_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0270096_0270281_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0270096_0270281_lanthipeptide

Lanthipeptides: allorf_295332_295517_lanthipeptide

HHITKWCDIKWKLRICESVKLFLSHNRSPISAFGSSRCYPFFASSIEHPQ

HHITKWCDIKWKLRICESVKLFLSHNRSPISAFGSS+CYPFFASSIEHPQ

HHITKWCDIKWKLRICESVKLFLSHNRSPISAFGSSQCYPFFASSIEHPQ

18.0%

NZ_CP114039.1:

Lanthipeptides: allorf_9368264_9368425_lanthipeptide

HNRSPISAFGSSRCYPFFASSIEH

RSP+ A GS+R A +++H

QTRSPVLAVGSAR-----AGALQH

with 7 more sequence matches

14.0%

NZ_AP018365.1:

Lanthipeptides: allorf_0038677_0038835_lanthipeptide

RSPISAFGSSRC

R P+SA G RC

RVPVSATGGHRC

14.0%

NZ_CP040424.1:

Lanthipeptides: allorf_0710205_0710291_lanthipeptide

SSRCYPFFASSIEH

S R YP FA + H

SERLYPLFAGGLLH

12.0%

NZ_CP062165.1:

Lanthipeptides: allorf_3871444_3871542_lanthipeptide

NRSPISAFGSSRCY

+++ SAFG ++CY

DQTGGSAFGFTKCY

12.0%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15515_lanthipeptide

KWCDIKWKLRIC

KWC + W+ IC

KWCTLTWECSIC

12.0%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

KWCDIKWKLRICES

KWC + W+ IC +

KWCTVTWECSICPT

10.0%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

KWCDIKWKLRICESVKLF

K+C + W+ +C ++ F

KYCTLTWECSVCPTLTCF

10.0%

NZ_CP013979.1:

Lanthipeptides: ATC03_RS01475_lanthipeptide

NRSPISAFGSSRCYPFFAS

+P+ FG C P+++

GTNPLGTFGCCWCVPWWSG

allorf_1176779_1176994

Leader:

MEIMMRTYCILPRWFDTVEGLARVAISLLQGRELIVGVLLRMQRMDSIESFRKLILGS

Core:

YCVIGTVLHSHIS

Core with dehydrations:

YCysVIGDhbVLHDhaHIDha

antiSMASH-DB 4.0 matches for allorf_1176779_1176994

100.0%

NZ_CP068102.1and 7 others:

NZ_CP068102.1 Lanthipeptides: allorf_1176779_1176994_lanthipeptideNZ_CP079819.1 Lanthipeptides: allorf_0013342_0013557_lanthipeptideNZ_CP079819.1 Lanthipeptides: allorf_0013342_0013557_lanthipeptideNZ_KI518028.1 Lanthipeptides: allorf_295232_295447_lanthipeptideNZ_KI518028.1 Lanthipeptides: allorf_295232_295447_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0269996_0270211_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0269996_0270211_lanthipeptide

Lanthipeptides: allorf_1176779_1176994_lanthipeptide

YCVIGTVLHSHIS

24.0%

NZ_JACHNX010000043.1:

Lanthipeptides: allorf_0139_0258_lanthipeptide

CVIGTVLHSH

CVIG HS

CVIGEADHSE

10.3%

NZ_CP045142.1:

Lanthipeptides: GBQ70_RS07075_lanthipeptide

YCVIGTVLHSHIS

YC T LH H S

YCDTPTRLHRHES

allorf_1181035_1181187

Leader:

MPQMMIWLQGTRSKYGA

Core:

NAPPAQLGTPRRPPPIRRRRAGCRNTRTFAKGT

Core with dehydrations:

NAPPAQLGDhbPRRPPPIRRRRAGCysRNDhbRDhbFAKGDhb

antiSMASH-DB 4.0 matches for allorf_1181035_1181187

100.0%

NZ_CP068102.1and 1 other:

NZ_CP068102.1 Lanthipeptides: allorf_1181035_1181187_lanthipeptide

Lanthipeptides: allorf_1181035_1181187_lanthipeptide

NAPPAQLGTPRRPPPIRRRRAGCRNTRTFAKGT

25.7%

NZ_CP017169.1:

Lanthipeptides: allorf_8041304_8041468_lanthipeptide

TPRRPPPIRRRRAGCRN

+P PPP+RR A CR+

SPSTPPPVRRHVAMCRH

24.2%

NZ_BMVE01000002.1and 1 other:

NZ_BMVE01000002.1 Lanthipeptides: allorf_0860736_0860912_lanthipeptide

Lanthipeptides: allorf_0860736_0860912_lanthipeptide

PPIRRRRAGCRNTRTFAKG

PP+ R R+ RT+A+G

PPLSSRGGVGRSLRTWARG

with 2 more sequence matches

18.2%

NZ_CP029560.1and 1 other:

NZ_JADOZM010000015.1 Lanthipeptides: I4U92_RS06525_lanthipeptide

Lanthipeptides: DLJ51_RS10415_lanthipeptide

AGCRNTRTFAKG

GC N TF+ G

GGCHNWSTFSIG

14.3%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: allorf_335018_335257_lanthipeptide

Lanthipeptides: allorf_335018_335257_lanthipeptide

TPRRPPPIRRRRAGCR

T RRPP + R R G R

TDRRPPAMSRSRTGAR

allorf_1181060_1181164

Leader:

MFLHPARRLLIGG

Core:

GLLGVPSCAGGAFAPYLLRVP

Core with dehydrations:

GLLGVPDhaCysAGGAFAPYLLRVP

antiSMASH-DB 4.0 matches for allorf_1181060_1181164

100.0%

NZ_CP068102.1and 5 others:

NZ_CP068102.1 Lanthipeptides: allorf_1181060_1181164_lanthipeptideNZ_CP079819.1 Lanthipeptides: allorf_0009138_0009242_lanthipeptideNZ_CP079819.1 Lanthipeptides: allorf_0009138_0009242_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0265791_0265895_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0265791_0265895_lanthipeptide

Lanthipeptides: allorf_1181060_1181164_lanthipeptide

GLLGVPSCAGGAFAPYLLRVP

26.9%

NC_014483.2and 23 others:

NC_014622.2 Lanthipeptides: PPSC2_RS36205_lanthipeptideNC_017542.1 Lanthipeptides: PPM_RS07465_lanthipeptideNZ_CP006872.1 Lanthipeptides: PPSQR21_RS07740_lanthipeptideNZ_CP023711.1 Lanthipeptides: CPY53_RS22235_lanthipeptideNZ_CP025957.1 Lanthipeptides: C1A50_RS07530_lanthipeptideNZ_CP029370.1 Lanthipeptides: DI243_RS07495_lanthipeptideNZ_CP040829.1 Lanthipeptides: FGY93_RS00500_lanthipeptideNZ_CP049598.1 Lanthipeptides: G7L40_RS00115_lanthipeptideNZ_CP061172.1 Lanthipeptides: IAQ67_RS07480_lanthipeptideNZ_CP073682.1 Lanthipeptides: KAI36_RS07745_lanthipeptideNZ_CP084033.1 Lanthipeptides: LAZ93_RS07550_lanthipeptideNZ_CP085682.1 Lanthipeptides: LJR53_RS07370_lanthipeptideNZ_CP086373.1 Lanthipeptides: LMH85_RS07780_lanthipeptideNZ_CP092779.1 Lanthipeptides: MJ749_RS07440_lanthipeptideNZ_CP097766.1 Lanthipeptides: MF620_RS07485_lanthipeptideNZ_CP102865.1 Lanthipeptides: NWS42_RS21195_lanthipeptideNZ_CP109848.1 Lanthipeptides: OF859_RS22650_lanthipeptideNZ_CP113973.1 Lanthipeptides: OYT09_RS07785_lanthipeptideNZ_JAAMNR010000001.1 Lanthipeptides: G9G54_RS03500_lanthipeptideNZ_JWJJ01000002.1 Lanthipeptides: U707_RS10390_lanthipeptideNZ_PNXQ01000013.1 Lanthipeptides: C1I60_RS14430_lanthipeptideNZ_POVS01000009.1 Lanthipeptides: C1T21_RS10630_lanthipeptideNZ_POVT01000009.1 Lanthipeptides: C1T20_RS05900_lanthipeptide

Lanthipeptides: PPE_RS07020_lanthipeptide

GLLGVPSCAGGAF

GL+ PSCA G

GLICTPSCATGTL

23.1%

NC_023037.2and 6 others:

NZ_CP017967.2 Lanthipeptides: PPYC1_RS07755_lanthipeptideNZ_CP017968.3 Lanthipeptides: PPYC2_RS08330_lanthipeptideNZ_CP073683.1 Lanthipeptides: KAI37_RS07495_lanthipeptideNZ_FOYG01000001.1 Lanthipeptides: BM358_RS03525_lanthipeptideNZ_JAKVDC010000001.1 Lanthipeptides: MKN04_RS02755_lanthipeptideNZ_PTJM01000020.1 Lanthipeptides: C5G87_RS02825_lanthipeptide

Lanthipeptides: X809_RS07820_lanthipeptide

GLLGVPSCAGGAF

G++ PSCA G

GIICTPSCATGTL

with 2 more sequence matches

15.7%

NZ_WWJS01000019.1:

Lanthipeptides: GT018_RS20925_lanthipeptide

GLLGVPSCAGGAFAPY

G VP +GG APY

GCQSVPDQSGGVVAPY

14.3%

NC_017765.1and 1 other:

NZ_KQ948355.1 Lanthipeptides: AQJ11_RS50945_lanthipeptide

Lanthipeptides: SHJG_RS52475_lanthipeptide

VPSCAGGAFAPY

VP+CAGG P+

VPACAGGIARPF

MIBiG 4.0 matches for allorf_1181060_1181164

19.0%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

SCAGGAFA

SC+ G F

SCSFGPFT

allorf_1181119_1181259

Leader:

MCRWRIRAVLAS

Core:

CSLKPDHHLGHPATGEGCRPASQSFTPGLIILAF

Core with dehydrations:

CysDhaLKPDHHLGHPADhbGEGCysRPADhaQDhaFDhbPGLIILAF

antiSMASH-DB 4.0 matches for allorf_1181119_1181259

100.0%

NZ_CP068102.1and 7 others:

NZ_CP068102.1 Lanthipeptides: allorf_1181119_1181259_lanthipeptideNZ_CP079819.1 Lanthipeptides: allorf_0009043_0009246_lanthipeptideNZ_CP079819.1 Lanthipeptides: allorf_0009043_0009246_lanthipeptideNZ_KI518028.1 Lanthipeptides: allorf_291916_292056_lanthipeptideNZ_KI518028.1 Lanthipeptides: allorf_291916_292056_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0265696_0265836_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0265696_0265836_lanthipeptide

Lanthipeptides: allorf_1181119_1181259_lanthipeptide

CSLKPDHHLGHPATGEGCRPASQSFTPGLIILAF

23.5%

NZ_CP069338.1and 1 other:

NZ_CP069338.1 Lanthipeptides: allorf_09109175_09109414_lanthipeptide

Lanthipeptides: allorf_09109175_09109414_lanthipeptide

HLGHPATGEGCRPASQSFT

G P EG P +SFT

EFGAPPLKEGNHPCLESFT

23.5%

NZ_SNZH01000011.1:

Lanthipeptides: allorf_218796_219029_lanthipeptide

TGEGCRPASQSFT

TG GCR A S T

TGSGCRKAGPSHT

with 1 more sequence matches

14.6%

NZ_LIPB01000002.1:

Lanthipeptides: allorf_1135461_1135619_lanthipeptide

HPATGEGCR

HP G GCR

HPWGGSGCR

MIBiG 4.0 matches for allorf_1181119_1181259

11.8%

BGC0000580.3 (EGD17355.1):

Lasso peptide: xanthomonin II or xanthomonin I

GHPATGE

G P GE

GGPLAGE

8.8%

BGC0000566.5 (SPy_0738):

LAP: streptolysin S

FTPG

+TPG

YTPG

allorf_1181240_1181359

Leader:

MTKYCMIHAKYYGA

Core:

ESQKLMFVIYCSPHLRGDTLRTQGL

Core with dehydrations:

EDhaQKLMFVIYCysDhaPHLRGDDhbLRDhbQGL

antiSMASH-DB 4.0 matches for allorf_1181240_1181359

100.0%

NZ_CP068102.1and 1 other:

NZ_CP068102.1 Lanthipeptides: allorf_1181240_1181359_lanthipeptide

Lanthipeptides: allorf_1181240_1181359_lanthipeptide

ESQKLMFVIYCSPHLRGDTLRTQGL

34.0%

NZ_CP079819.1and 5 others:

NZ_CP079819.1 Lanthipeptides: allorf_0008942_0009127_lanthipeptideNZ_KI518028.1 Lanthipeptides: allorf_291815_292000_lanthipeptideNZ_KI518028.1 Lanthipeptides: allorf_291815_292000_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0265595_0265780_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0265595_0265780_lanthipeptide

Lanthipeptides: allorf_0008942_0009127_lanthipeptide

ESQKLMFVIYCS-PHLRGDT

ESQKLMFVIYCS P RG T

ESQKLMFVIYCSPPSARGYT

28.0%

NZ_CP018295.1:

Lanthipeptides: allorf_1233116_1233202_lanthipeptide

VIYCSPHLRGDTLRT

I C L G T+RT

AIRCKKCLAGSTVRT

with 2 more sequence matches

24.0%

NZ_QGHB01000007.1:

Lanthipeptides: allorf_406636_406737_lanthipeptide

CSPHLRGDTLR

CSPH R R

CSPHARARFCR

15.0%

NZ_CP070496.1:

Lanthipeptides: allorf_3787129_3787275_lanthipeptide

SQKLMFVIYCSPHLRG

+ ++ V+ CSP RG

TAPIIRVVLCSPRTRG

Lanthipeptide(s) for I6I94_RS04845

I6I94_RS04840

Leader:

MPKDITLLEEISDQELGQVNGG

Core:

GSHGGGYYSSVGGGSYGGGYCGGGCGGYGYGFGFWGGSFS

Core with dehydrations:

GDhaHGGGYYDhaDhaVGGGDhaYGGGYCysGGGCysGGYGYGFGFWGGDhaFDha

antiSMASH-DB 4.0 matches for I6I94_RS04840

100.0%

NZ_CP068102.1and 7 others:

Lanthipeptides: I6I94_RS04840_lanthipeptide

GSHGGGYYSSVGGGSYGGGYCGGGCGGYGYGFGFWGGSFS

18.2%

NC_014643.1and 16 others:

Lanthipeptides: HMPREF0733_RS05060_lanthipeptide

YGFGFWGGS

+GFGFWGGS

FGFGFWGGS

MIBiG 4.0 matches for I6I94_RS04840

15.0%

BGC0002322.3 (CEJ66604.1):

Lasso peptide: citrocin

YCGGGCGGYG

+ GGG G YG

FIGGGVGRYG

I6I94_RS04850

Leader:

MAKDTMFMEELTDQELEQVNGG

Core:

CYSSCGYYGGSYGGSYGGSYCGSGSSYYGGGYYYAAVGYGYSC

Core with dehydrations:

CysYDhaDhaCysGYYGGDhaYGGDhaYGGDhaYCysGDhaGDhaDhaYYGGGYYYAAVGYGYDhaCys

antiSMASH-DB 4.0 matches for I6I94_RS04850

100.0%

NZ_CP068102.1and 1 other:

NZ_CP068102.1 Lanthipeptides: I6I94_RS04850_lanthipeptide

Lanthipeptides: I6I94_RS04850_lanthipeptide

CYSSCGYYGGSYGGSYGGSYCGSGSSYYGGGYYYAAVGYGYSC

87.5%

NZ_CP079819.1and 1 other:

NZ_CP079819.1 Lanthipeptides: LPB401_RS00090_lanthipeptide

Lanthipeptides: LPB401_RS00090_lanthipeptide

CYSSCGYYGGSYGGSYGGSYCGSGSSYY-----GGGYYYAAVGYGYSC

CYSSCGYYGGSYGGSYGGSYCGS SSYY GGGYYYAAVGYGYSC

CYSSCGYYGGSYGGSYGGSYCGSSSSYYGGSYSGGGYYYAAVGYGYSC

19.1%

NZ_QFWW01000059.1:

Lanthipeptides: allorf_187545_187781_lanthipeptide

GGSYGGSYGGSYCGSG-SSYYGGGYYYAAVGYGYSC

GG + GG++ +G S++ GGG + AA+G S

GGDWRAVVGGAWRVAGCSAWPGGGDWRAALGEARSA

with 2 more sequence matches

18.0%

NC_015953.1:

Lanthipeptides: allorf_2485079_2485273_lanthipeptide

SYGGSYCGSGSSYYGGGYYYAAVG

GG CG+ YG G A G

KLGGPACGTLRRRYGAGIAPARRG

17.9%

NZ_CP025394.1and 1 other:

NZ_CP025394.1 Lanthipeptides: CFP65_RS07275_lanthipeptide

Lanthipeptides: CFP65_RS07275_lanthipeptide

SSCGYYGGSYGGSYGGSYCGS

S G GS GS+ GS+ GS

SQPGSRPGSRPGSWTGSWTGS

MIBiG 4.0 matches for I6I94_RS04850

14.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

CGYYGGSYGGSYGGSYC

C +Y S G+YC

CAWYNISCRLGNKGAYC

9.3%

BGC0000581.6 (AAD28494.1):

Lasso peptide: microcin J25

CGSGSSYYG

G+ S+YG

IGTPISFYG

allorf_1166508_1166591

Leader:

MVNNLYGG

Core:

GYFCSLVVSSCSLVDTHPA

Core with dehydrations:

GYFCysDhaLVVDhaDhaCysDhaLVDDhbHPA

antiSMASH-DB 4.0 matches for allorf_1166508_1166591

100.0%

NZ_CP068102.1and 3 others:

NZ_CP068102.1 Lanthipeptides: allorf_1166508_1166591_lanthipeptideNZ_CP079819.1 Lanthipeptides: allorf_0023758_0023841_lanthipeptideNZ_CP079819.1 Lanthipeptides: allorf_0023758_0023841_lanthipeptide

Lanthipeptides: allorf_1166508_1166591_lanthipeptide

GYFCSLVVSSCSLVDTHPA

MIBiG 4.0 matches for allorf_1166508_1166591

5.9%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

CSLVVSSC

C++ ++C

CNMKTATC

allorf_1176509_1176580

Leader:

MVENRDLASS

Core:

SPKYSAIKNCSRK

Core with dehydrations:

DhaPKYDhaAIKNCysDhaRK

antiSMASH-DB 4.0 matches for allorf_1176509_1176580

100.0%

NZ_CP068102.1and 1 other:

NZ_CP068102.1 Lanthipeptides: allorf_1176509_1176580_lanthipeptide

Lanthipeptides: allorf_1176509_1176580_lanthipeptide

SPKYSAIKNCSRK

92.3%

NZ_CP079819.1and 3 others:

NZ_CP079819.1 Lanthipeptides: allorf_0013756_0013827_lanthipeptideNZ_KI518028.1 Lanthipeptides: allorf_295646_295717_lanthipeptideNZ_KI518028.1 Lanthipeptides: allorf_295646_295717_lanthipeptide

Lanthipeptides: allorf_0013756_0013827_lanthipeptide

SPKYSAIKNCSRK

SPK+SAIKNCSRK

SPKHSAIKNCSRK

84.6%

NZ_LR134479.1and 1 other:

NZ_LR134479.1 Lanthipeptides: allorf_0270410_0270481_lanthipeptide

Lanthipeptides: allorf_0270410_0270481_lanthipeptide

SPKYSAIKNCSRK

SPK+S IKNCSRK

SPKHSTIKNCSRK

with 1 more sequence matches

21.4%

NZ_RYYV01000004.1:

Lanthipeptides: allorf_108405_108521_lanthipeptide

PKYSAIKNCSRK

P++ NCSRK

PRWKISNNCSRK

allorf_1176709_1176894

Leader:

MLCALIALYYG

Core:

HHITKWCDIKWKLRICESVKLFLSHNRSPISAFGSSRCYPFFASSIEHPQ

Core with dehydrations:

HHIDhbKWCysDIKWKLRICysEDhaVKLFLDhaHNRDhaPIDhaAFGDhaDhaRCysYPFFADhaDhaIEHPQ

antiSMASH-DB 4.0 matches for allorf_1176709_1176894

100.0%

NZ_CP068102.1and 1 other:

NZ_CP068102.1 Lanthipeptides: allorf_1176709_1176894_lanthipeptide

Lanthipeptides: allorf_1176709_1176894_lanthipeptide

HHITKWCDIKWKLRICESVKLFLSHNRSPISAFGSSRCYPFFASSIEHPQ

98.0%

NZ_KI518028.1and 3 others:

NZ_KI518028.1 Lanthipeptides: allorf_295332_295517_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0270096_0270281_lanthipeptideNZ_LR134479.1 Lanthipeptides: allorf_0270096_0270281_lanthipeptide

Lanthipeptides: allorf_295332_295517_lanthipeptide

HHITKWCDIKWKLRICESVKLFLSHNRSPISAFGSSRCYPFFASSIEHPQ

HHITKWCDIKWKLRICESVKLFLSHNRSPISAFGSS+CYPFFASSIEHPQ

HHITKWCDIKWKLRICESVKLFLSHNRSPISAFGSSQCYPFFASSIEHPQ

18.0%

NZ_CP114039.1:

Lanthipeptides: allorf_9368264_9368425_lanthipeptide

HNRSPISAFGSSRCYPFFASSIEH

RSP+ A GS+R A +++H

QTRSPVLAVGSAR-----AGALQH

with 7 more sequence matches

14.0%

NZ_AP018365.1:

Lanthipeptides: allorf_0038677_0038835_lanthipeptide

RSPISAFGSSRC

R P+SA G RC

RVPVSATGGHRC

14.0%

NZ_CP040424.1:

Lanthipeptides: allorf_0710205_0710291_lanthipeptide

SSRCYPFFASSIEH

S R YP FA + H

SERLYPLFAGGLLH

12.0%

NZ_CP062165.1:

Lanthipeptides: allorf_3871444_3871542_lanthipeptide

NRSPISAFGSSRCY

+++ SAFG ++CY

DQTGGSAFGFTKCY

12.0%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15515_lanthipeptide

KWCDIKWKLRIC

KWC + W+ IC

KWCTLTWECSIC

12.0%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

KWCDIKWKLRICES

KWC + W+ IC +

KWCTVTWECSICPT

10.0%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

KWCDIKWKLRICESVKLF

K+C + W+ +C ++ F

KYCTLTWECSVCPTLTCF

10.0%

NZ_CP013979.1:

Lanthipeptides: ATC03_RS01475_lanthipeptide

NRSPISAFGSSRCYPFFAS

+P+ FG C P+++

GTNPLGTFGCCWCVPWWSG

allorf_1176779_1176994

Leader:

MEIMMRTYCILPRWFDTVEGLARVAISLLQGRELIVGVLLRMQRMDSIESFRKLILGS

Core:

YCVIGTVLHSHIS

Core with dehydrations:

YCysVIGDhbVLHDhaHIDha

antiSMASH-DB 4.0 matches for allorf_1176779_1176994

100.0%

NZ_CP068102.1and 7 others:

Lanthipeptides: allorf_1176779_1176994_lanthipeptide

YCVIGTVLHSHIS

24.0%

NZ_JACHNX010000043.1:

Lanthipeptides: allorf_0139_0258_lanthipeptide

CVIGTVLHSH

CVIG HS

CVIGEADHSE

10.3%

NZ_CP045142.1:

Lanthipeptides: GBQ70_RS07075_lanthipeptide

YCVIGTVLHSHIS

YC T LH H S

YCDTPTRLHRHES

allorf_1181035_1181187

Leader:

MPQMMIWLQGTRSKYGA

Core:

NAPPAQLGTPRRPPPIRRRRAGCRNTRTFAKGT

Core with dehydrations:

NAPPAQLGDhbPRRPPPIRRRRAGCysRNDhbRDhbFAKGDhb

antiSMASH-DB 4.0 matches for allorf_1181035_1181187

100.0%

NZ_CP068102.1and 1 other:

NZ_CP068102.1 Lanthipeptides: allorf_1181035_1181187_lanthipeptide

Lanthipeptides: allorf_1181035_1181187_lanthipeptide

NAPPAQLGTPRRPPPIRRRRAGCRNTRTFAKGT

25.7%

NZ_CP017169.1:

Lanthipeptides: allorf_8041304_8041468_lanthipeptide

TPRRPPPIRRRRAGCRN

+P PPP+RR A CR+

SPSTPPPVRRHVAMCRH

24.2%

NZ_BMVE01000002.1and 1 other:

NZ_BMVE01000002.1 Lanthipeptides: allorf_0860736_0860912_lanthipeptide

Lanthipeptides: allorf_0860736_0860912_lanthipeptide

PPIRRRRAGCRNTRTFAKG

PP+ R R+ RT+A+G

PPLSSRGGVGRSLRTWARG

with 2 more sequence matches

18.2%

NZ_CP029560.1and 1 other:

NZ_JADOZM010000015.1 Lanthipeptides: I4U92_RS06525_lanthipeptide

Lanthipeptides: DLJ51_RS10415_lanthipeptide

AGCRNTRTFAKG

GC N TF+ G

GGCHNWSTFSIG

14.3%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: allorf_335018_335257_lanthipeptide

Lanthipeptides: allorf_335018_335257_lanthipeptide

TPRRPPPIRRRRAGCR

T RRPP + R R G R

TDRRPPAMSRSRTGAR

allorf_1181060_1181164

Leader:

MFLHPARRLLIGG

Core:

GLLGVPSCAGGAFAPYLLRVP

Core with dehydrations:

GLLGVPDhaCysAGGAFAPYLLRVP

antiSMASH-DB 4.0 matches for allorf_1181060_1181164

100.0%

NZ_CP068102.1and 5 others:

Lanthipeptides: allorf_1181060_1181164_lanthipeptide

GLLGVPSCAGGAFAPYLLRVP

26.9%

NC_014483.2and 23 others:

Lanthipeptides: PPE_RS07020_lanthipeptide

GLLGVPSCAGGAF

GL+ PSCA G

GLICTPSCATGTL

23.1%

NC_023037.2and 6 others:

Lanthipeptides: X809_RS07820_lanthipeptide

GLLGVPSCAGGAF

G++ PSCA G

GIICTPSCATGTL

with 2 more sequence matches

15.7%

NZ_WWJS01000019.1:

Lanthipeptides: GT018_RS20925_lanthipeptide

GLLGVPSCAGGAFAPY

G VP +GG APY

GCQSVPDQSGGVVAPY

14.3%

NC_017765.1and 1 other:

NZ_KQ948355.1 Lanthipeptides: AQJ11_RS50945_lanthipeptide

Lanthipeptides: SHJG_RS52475_lanthipeptide

VPSCAGGAFAPY

VP+CAGG P+

VPACAGGIARPF

MIBiG 4.0 matches for allorf_1181060_1181164

19.0%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

SCAGGAFA

SC+ G F

SCSFGPFT

allorf_1181119_1181259

Leader:

MCRWRIRAVLAS

Core:

CSLKPDHHLGHPATGEGCRPASQSFTPGLIILAF

Core with dehydrations:

CysDhaLKPDHHLGHPADhbGEGCysRPADhaQDhaFDhbPGLIILAF

antiSMASH-DB 4.0 matches for allorf_1181119_1181259

100.0%

NZ_CP068102.1and 7 others:

Lanthipeptides: allorf_1181119_1181259_lanthipeptide

CSLKPDHHLGHPATGEGCRPASQSFTPGLIILAF

23.5%

NZ_CP069338.1and 1 other:

NZ_CP069338.1 Lanthipeptides: allorf_09109175_09109414_lanthipeptide

Lanthipeptides: allorf_09109175_09109414_lanthipeptide

HLGHPATGEGCRPASQSFT

G P EG P +SFT

EFGAPPLKEGNHPCLESFT

23.5%

NZ_SNZH01000011.1:

Lanthipeptides: allorf_218796_219029_lanthipeptide

TGEGCRPASQSFT

TG GCR A S T

TGSGCRKAGPSHT

with 1 more sequence matches

14.6%

NZ_LIPB01000002.1:

Lanthipeptides: allorf_1135461_1135619_lanthipeptide

HPATGEGCR

HP G GCR

HPWGGSGCR

MIBiG 4.0 matches for allorf_1181119_1181259

11.8%

BGC0000580.3 (EGD17355.1):

Lasso peptide: xanthomonin II or xanthomonin I

GHPATGE

G P GE

GGPLAGE

8.8%

BGC0000566.5 (SPy_0738):

LAP: streptolysin S

FTPG

+TPG

YTPG

allorf_1181240_1181359

Leader:

MTKYCMIHAKYYGA

Core:

ESQKLMFVIYCSPHLRGDTLRTQGL

Core with dehydrations:

EDhaQKLMFVIYCysDhaPHLRGDDhbLRDhbQGL

antiSMASH-DB 4.0 matches for allorf_1181240_1181359

100.0%

NZ_CP068102.1and 1 other:

NZ_CP068102.1 Lanthipeptides: allorf_1181240_1181359_lanthipeptide

Lanthipeptides: allorf_1181240_1181359_lanthipeptide

ESQKLMFVIYCSPHLRGDTLRTQGL

34.0%

NZ_CP079819.1and 5 others:

Lanthipeptides: allorf_0008942_0009127_lanthipeptide

ESQKLMFVIYCS-PHLRGDT

ESQKLMFVIYCS P RG T

ESQKLMFVIYCSPPSARGYT

28.0%

NZ_CP018295.1:

Lanthipeptides: allorf_1233116_1233202_lanthipeptide

VIYCSPHLRGDTLRT

I C L G T+RT

AIRCKKCLAGSTVRT

with 2 more sequence matches

24.0%

NZ_QGHB01000007.1:

Lanthipeptides: allorf_406636_406737_lanthipeptide

CSPHLRGDTLR

CSPH R R

CSPHARARFCR

15.0%

NZ_CP070496.1:

Lanthipeptides: allorf_3787129_3787275_lanthipeptide

SQKLMFVIYCSPHLRG

+ ++ V+ CSP RG

TAPIIRVVLCSPRTRG

allorf_1185663_1185779

Leader:

MNEIQLIGA

Core:

PQPPPTRGTRGALRRAPARKCIKIRYVRG

Core with dehydrations:

PQPPPDhbRGDhbRGALRRAPARKCysIKIRYVRG

antiSMASH-DB 4.0 matches for allorf_1185663_1185779

100.0%

NZ_CP068102.1:

Lanthipeptides: allorf_1185663_1185779_lanthipeptide

PQPPPTRGTRGALRRAPARKCIKIRYVRG

96.6%

NZ_KI518028.1:

Lanthipeptides: allorf_287397_287513_lanthipeptide

PQPPPTRGTRGALRRAPARKCIKIRYVRG

PQPPPTRGTRGALRRAPA+KCIKIRYVRG

PQPPPTRGTRGALRRAPAQKCIKIRYVRG

93.1%

NZ_LR134479.1:

Lanthipeptides: allorf_0261182_0261298_lanthipeptide

PQPPPTRGTRGALRRAPARKCIKIRYVRG

PQPPPTRGTRGALRRAPA++CIKIRYVRG

PQPPPTRGTRGALRRAPAQECIKIRYVRG

with 5 more sequence matches

29.7%

NZ_CP013219.1:

Lanthipeptides: allorf_0179059_0179217_lanthipeptide

PQPPPTRGTRGALRRAPAR

P PP G RGA RR P R

PVPPADGGPRGAGRRVPCR

24.1%

NZ_CP026498.1:

Lanthipeptides: allorf_00224338_00224481_lanthipeptide

PTRGTRGALRRAPA

P G+RG +RR P

PRNGSRGGVRRRPG

22.9%

NZ_CP022098.1:

Lanthipeptides: allorf_01007786_01007962_lanthipeptide

PPTRGTRGALRRAP-------ARKCIKI

P +R + ALRRAP RKC+ +

PSSRASLRALRRAPFIAARGLDRKCLTL

18.6%

NZ_CP017170.1:

Lanthipeptides: allorf_7967497_7967682_lanthipeptide

RGTRGALRRAPARKC

R +RG L++A AR C

RRSRGGLKQARARSC

15.8%

NZ_CP011505.1:

Lanthipeptides: allorf_0567554_0567700_lanthipeptide

TRGALRRAPARKCI

T A+R AR+C+

THQAIRTVVARECV

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 21.84 out of 21.84

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 24.59 out of 29.72

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.08 out of 18.57

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.39 out of 27.78

Confidence: medium

Additional weak hits (18):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.81 out of 36.54

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.72 out of 32.93

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.99 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.44 out of 27.78

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.54 out of 21.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.92 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.52 out of 27.78

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.84 out of 32.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.75 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.71 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.12 out of 31.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.75 out of 26.12

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.41 out of 33.73

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.97 out of 32.93

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.27 out of 20.01

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.72 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.24 out of 32.38

Confidence: weak

Lanthipeptides

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

I6I94_RS04840 - Class II

Cleavage pHMM score: 3.20

RODEO score: 0

Monoisotopic mass: 3620.4 Da

Molecular weight: 3622.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3640.7 Da N = 1; 3658.8 Da N = 2; 3676.8 Da N = 3; 3694.8 Da N = 4

I6I94_RS04850 - Class II

Cleavage pHMM score: 4.70

RODEO score: 0

Monoisotopic mass: 4210.6 Da

Molecular weight: 4213.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4231.4 Da N = 1; 4249.4 Da N = 2; 4267.4 Da N = 3; 4285.4 Da N = 4; 4303.5 Da N = 5

allorf_1166508_1166591 - Class II

Cleavage pHMM score: -5.10

RODEO score: 0

Monoisotopic mass: 1893.9 Da

Molecular weight: 1895.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1913.2 Da N = 1; 1931.2 Da N = 2; 1949.2 Da N = 3

allorf_1176509_1176580 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 1426.8 Da

Molecular weight: 1427.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1445.7 Da N = 1; 1463.7 Da N = 2

allorf_1176709_1176894 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 5724.0 Da

Molecular weight: 5727.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 5745.6 Da N = 1; 5763.6 Da N = 2; 5781.6 Da N = 3; 5799.6 Da N = 4; 5817.7 Da N = 5; 5835.7 Da N = 6

allorf_1176779_1176994 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 1373.7 Da

Molecular weight: 1374.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1392.6 Da N = 1; 1410.6 Da N = 2

allorf_1181035_1181187 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 3597.0 Da

Molecular weight: 3599.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3617.2 Da N = 1; 3635.2 Da N = 2; 3653.2 Da N = 3

allorf_1181060_1181164 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 2039.1 Da

Molecular weight: 2040.4 Da

Number of bridges: 1

allorf_1181119_1181259 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 3466.8 Da

Molecular weight: 3468.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3487.0 Da N = 1; 3505.0 Da N = 2; 3523.0 Da N = 3

allorf_1181240_1181359 - Class II

Cleavage pHMM score: -5.30

RODEO score: 0

Monoisotopic mass: 2819.5 Da

Molecular weight: 2821.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2839.3 Da N = 1; 2857.3 Da N = 2; 2875.3 Da N = 3

I6I94_RS04840 - Class II

Cleavage pHMM score: 3.20

RODEO score: 0

Monoisotopic mass: 3620.4 Da

Molecular weight: 3622.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3640.7 Da N = 1; 3658.8 Da N = 2; 3676.8 Da N = 3; 3694.8 Da N = 4

I6I94_RS04850 - Class II

Cleavage pHMM score: 4.70

RODEO score: 0

Monoisotopic mass: 4210.6 Da

Molecular weight: 4213.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4231.4 Da N = 1; 4249.4 Da N = 2; 4267.4 Da N = 3; 4285.4 Da N = 4; 4303.5 Da N = 5

allorf_1166508_1166591 - Class II

Cleavage pHMM score: -5.10

RODEO score: 0

Monoisotopic mass: 1893.9 Da

Molecular weight: 1895.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1913.2 Da N = 1; 1931.2 Da N = 2; 1949.2 Da N = 3

allorf_1176509_1176580 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 1426.8 Da

Molecular weight: 1427.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1445.7 Da N = 1; 1463.7 Da N = 2

allorf_1176709_1176894 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 5724.0 Da

Molecular weight: 5727.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 5745.6 Da N = 1; 5763.6 Da N = 2; 5781.6 Da N = 3; 5799.6 Da N = 4; 5817.7 Da N = 5; 5835.7 Da N = 6

allorf_1176779_1176994 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 1373.7 Da

Molecular weight: 1374.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1392.6 Da N = 1; 1410.6 Da N = 2

allorf_1181035_1181187 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 3597.0 Da

Molecular weight: 3599.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3617.2 Da N = 1; 3635.2 Da N = 2; 3653.2 Da N = 3

allorf_1181060_1181164 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 2039.1 Da

Molecular weight: 2040.4 Da

Number of bridges: 1

allorf_1181119_1181259 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 3466.8 Da

Molecular weight: 3468.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3487.0 Da N = 1; 3505.0 Da N = 2; 3523.0 Da N = 3

allorf_1181240_1181359 - Class II

Cleavage pHMM score: -5.30

RODEO score: 0

Monoisotopic mass: 2819.5 Da

Molecular weight: 2821.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2839.3 Da N = 1; 2857.3 Da N = 2; 2875.3 Da N = 3

allorf_1185663_1185779 - Class II

Cleavage pHMM score: -5.20

RODEO score: 0

Monoisotopic mass: 3234.9 Da

Molecular weight: 3236.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3254.9 Da N = 1

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 14 - 94; Score: 38.4

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MexT	Global virulence regulator
NtrC	Nitrogen regulatory protein C
ToxT	Regulator of MSHA biosynthesis

NZ_CP068102.1 - Region 3 - NRPS

Download region GenBank file

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Location: 2,454,467 - 2,498,723 nt. (total: 44,257 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

I6I94_RS10925: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: formyltransferase transketolase

I6I94_RS10835: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

I6I94_RS10915: transketolase

smcogs: SMCOG1204: transketolase

Hydrolases: deformylase esterase

I6I94_RS10830: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

I6I94_RS10880: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

Ligases: ligase synthase

I6I94_RS10885: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

I6I94_RS10945: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002685.2	0.79	NRPS	enterobactin	Rothia mucilaginosa ATCC 25296
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.64	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002685.2	0.79	NRPS	enterobactin	Rothia mucilaginosa ATCC 25296
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.64	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 21.40 out of 23.05

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 30.25

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

Additional weak hits (11):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.56 out of 28.14

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.22 out of 25.75

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.00 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.95 out of 39.62

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.55 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.59 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.47 out of 29.38

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.90 out of 30.98

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.24 out of 29.25

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.03 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 5, location 2454466 - 2498723:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

I6I94_RS10885: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (50..465): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SGSLFTMSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz TMPSQGVVNK (94% 8Å match)
Stachelhaus code match:: 90% (moderate)

I6I94_RS10895: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (516..966): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWQTFDVHVWEWHFVCSGELNLYGPTEAAVDVTF
Nearest Stachelhaus code(s):: Ser DVWHVSLVDK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
ColR	Phenol-responsive regulator
VqsM	Regulator of quorum-sensing signalling systems