LOCUS       NZ_CP068102            21134 bp    DNA     circular CON 12-DEC-2024
DEFINITION  Rothia aeria strain FDAARGOS_1137 chromosome, complete genome.
ACCESSION   NZ_CP068102
VERSION     NZ_CP068102.1
KEYWORDS    RefSeq.
SOURCE      Rothia aeria
  ORGANISM  Rothia aeria
            Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micrococcales;
            Micrococcaceae; Rothia.
REFERENCE   1  (bases 1 to 2583917)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T., Yan,Y.
            and Sichtig,H.
  TITLE     FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
            Supporting development and validation of Infectious Disease Dx tests
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2583917)
  AUTHORS   Sproer,C., Gronow,S., Severitt,S., Schroder,I., Tallon,L.,
            Sadzewicz,L., Zhao,X., Boylan,J., Ott,S., Bowen,H., Vavikolanu,K.,
            Mehta,A., Aluvathingal,J., Nadendla,S., Lowell,S., Myers,T., Yan,Y.
            and Sichtig,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JAN-2021) Institute for Genome Sciences, University of
            Maryland School of Medicine, BioPark II, 801 W. Baltimore St., Suite
            619, Baltimore, MD 21201, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT v. 8.0.0, HGAP v. 4
            Genome Coverage                   :: 941.26x
            Sequencing Technology             :: Pacbio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016726365.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 16:41:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,276
            CDSs (total)                      :: 2,214
            Genes (coding)                    :: 2,202
            CDSs (with protein)               :: 2,202
            Genes (RNA)                       :: 62
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 12
            CDSs (without protein)            :: 12
            Pseudo Genes (ambiguous residues) :: 0 of 12
            Pseudo Genes (frameshifted)       :: 2 of 12
            Pseudo Genes (incomplete)         :: 10 of 12
            Pseudo Genes (internal stop)      :: 2 of 12
            Pseudo Genes (multiple problems)  :: 2 of 12
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:52:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 598349
            Orig. end                         :: 619483
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP068102.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21134
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21134
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21134
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11134](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11134
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(568..2310)
                     /db_xref="GeneID:93861124"
                     /locus_tag="I6I94_RS02495"
                     /old_locus_tag="I6I94_02495"
     CDS             complement(568..2310)
                     /EC_number="6.3.2.13"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:93861124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888886.1"
                     /locus_tag="I6I94_RS02495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02495"
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,
                     6-diaminopimelate ligase"
                     /protein_id="WP_126926539.1"
                     /transl_table=11
                     /translation="MNGEQPGEKLSDEAMPGEELFGKDAQNLRPRLTTGYPLDTLIQKL
                     QNLEAQPHLALSGSRNVTGISMDSRSVREGDLYVALPGAKTHGASFAAAAVAAGAAGIL
                     TDAQGQRIIAEAHLDLADTALIIGTDLRRVLGSLAAFIYGSNDYPQLQRFAVTGTNGKT
                     TTTYMLESVFRAALGVKTGLVGTIQILIDGVSIPSAMTTPESVHVHALLSLMGQRGVRC
                     AAMEVSSHAIDYRRVDGVRYAMSGFTNLTQDHLDLHGGMEEYFDSKAQLFTPERTERAV
                     ITADDPWGQRMLVRAQQQLGAQNTIRLLTNHGAGLEAVPADFGVNDWAVTEVMAQGLGH
                     TFVLANGAGERVQARTGLPADFNVSNAALAALMAWLSTSEEEREPLAAALASGEALTPV
                     VPGRMQLIGHSPHTIVDFAHNPDGLIRALEAMDRPGEGRVIIVFGATGERDQGKRPIMG
                     EIAARYADIVIVTDDDPHGEDPAPIREAVAAGAQQAIAAGARAHEVHNIAPRARAIAQA
                     IDMATPDDAVLIAGRGHETAQDVAGVDVQLDDRIEVARAMVTRGFEILPDYRRMLEENA
                     EDKK"
     gene            complement(2434..4281)
                     /db_xref="GeneID:93861125"
                     /locus_tag="I6I94_RS02500"
                     /old_locus_tag="I6I94_02500"
     CDS             complement(2434..4281)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:93861125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888847.1"
                     /locus_tag="I6I94_RS02500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02500"
                     /product="penicillin-binding protein 2"
                     /protein_id="WP_006888847.1"
                     /transl_table=11
                     /translation="MAHKKKAVSSQSERKLSRRGFMIGASSTGLLGLLSLRLLYVQGLD
                     PQNLAATSRDSRTRTQKVPAVRGQITDVNGHVLARSVQRYNIIADQTIVAEFKRYDHSQ
                     ERVTVTPTELVYEVTDILRTVDPTITDDFVKSKLEGDSRYSVIKTNVTPEIYNRIDALG
                     APFLFGEVISERLYPDGPVGGSVVGRYRIVDEAVEGKENETVERNLSVGIERTFEKELA
                     GVNGKRVYEIGADGVRIPVTQEQVSESVNGKTVRLTLNRDIQYYAQQVMKARVDELKAE
                     WGCAIVMDVRDGSILALADSTTMDPGAEKVENTQDMVPRAISQIIEPGSTEKILTASAL
                     IEKGITTPTDTYDVPATLTVNGQTFKDAFEHPAQRRTFSGIITDSMNTGTVLVGQKMPK
                     EERYEWLKKYGMGEFTGIDIAGEQQGLVSDWKTWDGRQEFTVFFGQGLAQTPLQTAMVF
                     QAVGNLGVKVKPRIVDAIIDPDGTEHKVPVEGAQRVVSEKTARDCLTLMENVVTKGQAK
                     LAQVNGYRVGGKTGTAEAPSEKGGYEGYTTSFIGVAPIENPRFMVSITLQRPKGEVGTI
                     GGTGQFSQIMERVLHTYNIPHSTTEPHIIPIFADGKNSG"
     gene            complement(4455..5555)
                     /db_xref="GeneID:93861126"
                     /locus_tag="I6I94_RS02505"
                     /old_locus_tag="I6I94_02505"
     CDS             complement(4455..5555)
                     /codon_start=1
                     /db_xref="GeneID:93861126"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I6I94_RS02505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="I6I94_02505"
                     /product="hypothetical protein"
                     /protein_id="WP_126926540.1"
                     /transl_table=11
                     /translation="MSVTTKTTMTGERRNTPKPPGRKTRPEGTAAAPGRAGSSHPGSAR
                     RASTTSTSTRRTAQKEKVGASSRAATAGSTTRTSTPSRARTTETARSQGAGAMRTSRGA
                     TLLDAPARFLAYTRGVAGVFEKPSTAQFEANTTSARPKPARGGTAGRAEVREASGAKKR
                     APLARSLRKPTRRGGIMSLLMWAVFLVIPLFLIFNLLMNILVAQRQYELVDMHAQELAL
                     TQQNEALHQELGYNEAPQDLAIRASLLNMFPSTTPATLDVQNGTIQGTPTPAASPTSAN
                     GTRGNLVPAPATRDNDPSGQKAADAQKQAQEKTAKQNREREEKEKQEKEKASAAASPSP
                     SASPQGSQSPQQAQPSQAAPSASANR"
     gene            complement(5556..6608)
                     /db_xref="GeneID:93861127"
                     /gene="rsmH"
                     /locus_tag="I6I94_RS02510"
                     /old_locus_tag="I6I94_02510"
     CDS             complement(5556..6608)
                     /EC_number="2.1.1.199"
                     /GO_function="GO:0016434 - rRNA (cytosine)
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:93861127"
                     /gene="rsmH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888919.1"
                     /locus_tag="I6I94_RS02510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02510"
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="WP_126926541.1"
                     /transl_table=11
                     /translation="MSAKESTHAGAQGAVAPAHTLTLTETPDAGLSKKEAKERHVPVML
                     TRCLDLLAPALEREGAVVIDGTLGMGGHTEAMLERFPELQVIGIDRDPQAHTIAGQRLE
                     RFGERFIPVHAVYDQIEYAMDVAGVNAVDGVLFDLGVSSMQLDERSRGFAYSYDAPLDM
                     RMNSEDELTARTVVNEYPLERLQRIIRTWGEEKFAARIAERIVAQRAVQPFETTGELVA
                     AIQKAVPAAAQRKGGHPAKRTFQALRIEVNHELEALERAVPVAIDSLSLGGRFVAMSYH
                     SLEDKIVKRGLSAAATSKAPKGFPVELDEHKPTMKVITRGAEPPTEAEIAENSRAASAK
                     LRAGEKIRVT"
     gene            complement(6676..7104)
                     /db_xref="GeneID:93861128"
                     /gene="mraZ"
                     /locus_tag="I6I94_RS02515"
                     /old_locus_tag="I6I94_02515"
     CDS             complement(6676..7104)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:93861128"
                     /gene="mraZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888897.1"
                     /locus_tag="I6I94_RS02515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02515"
                     /product="division/cell wall cluster transcriptional
                     repressor MraZ"
                     /protein_id="WP_006888897.1"
                     /transl_table=11
                     /translation="MFLGTYSPRLDTKGRIILPAKFREELSAGLVLTRGQERCLYVFSA
                     EEFERIHEQMRSAPLSSRQARDYMRVFLSGASDEVPDKQGRVTIPAALREYARLDRELV
                     VIGAGSRAEIWDAQAWDEYLARTEAEFAQLDEEPFPFL"
     misc_feature    7193..7207
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.83"
                     /tool="antismash"
     gene            complement(7730..8128)
                     /db_xref="GeneID:93861129"
                     /locus_tag="I6I94_RS02520"
                     /old_locus_tag="I6I94_02520"
     CDS             complement(7730..8128)
                     /codon_start=1
                     /db_xref="GeneID:93861129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888833.1"
                     /locus_tag="I6I94_RS02520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02520"
                     /product="DUF3040 domain-containing protein"
                     /protein_id="WP_023134584.1"
                     /transl_table=11
                     /translation="MALSEREQKVLDQLEELMHAEDPQFASSMSSTGNTAPVFSARHMV
                     LGILCVLAGLGIIIGAVASKIILLGIVGFIVAAGGVYFATTSKKTPIDSFLGGKAKGAS
                     AEKAQQQRKQSKLMERLEERWDEREQGR"
     gene            complement(8439..9776)
                     /db_xref="GeneID:93861130"
                     /gene="dinB"
                     /locus_tag="I6I94_RS02525"
                     /old_locus_tag="I6I94_02525"
     CDS             complement(8439..9776)
                     /EC_number="2.7.7.7"
                     /GO_function="GO:0003684 - damaged DNA binding [Evidence
                     IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:93861130"
                     /gene="dinB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888896.1"
                     /locus_tag="I6I94_RS02525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02525"
                     /product="DNA polymerase IV"
                     /protein_id="WP_174232410.1"
                     /transl_table=11
                     /translation="MSENVKNIFNTSRFQRGNTADDRSEKPRIMMHLDMDAFFVNVELL
                     NKPELHGTPIIVAHEGPRSVVCSASYEARDSGVHSGMPLARAKRLSPQATILPLRGDYG
                     FYSRAVMRILRDESPLVEQVSVDEAFIDLTGATAIGGSPVAIAQRVRERIADELSLPCS
                     AGISINKFLAKMASTGSKPNGLWVVPPHRVQEFLDPMPVNKLWGVGARSATLLNEYGIY
                     TVAQLREFDAQWLCGRFGNAAGNHLYALARGIDHRPVVTERVEKSMGAEHTFAADTRCV
                     ADIERAVQGIALRLGRRLRAAGKTAGALTIKYRYEGFETHTKSIPLTEPVDSGMQIYRI
                     ACAALRAMGLLIKSCDGQKEQASRALRLIGVRAERLQQCASGVQQTLFALDPQEGDGAE
                     KADWGRVERALDGIHTRFSAEAVRPASLMGYTAGRTHMHRVQHRQG"
     misc_feature    complement(9864..9882)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 21.44"
                     /tool="antismash"
     misc_feature    9867..9885
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 25.59"
                     /tool="antismash"
     misc_feature    complement(9885..9898)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 18.44"
                     /tool="antismash"
     misc_feature    complement(9893..9902)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.04"
                     /tool="antismash"
     misc_feature    9940..9960
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.65"
                     /tool="antismash"
     misc_feature    complement(9949..9965)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.87"
                     /tool="antismash"
     gene            10001..11134
                     /db_xref="GeneID:93861131"
                     /locus_tag="I6I94_RS02530"
                     /old_locus_tag="I6I94_02530"
     CDS             10001..11134
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:93861131"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888910.1"
                     /locus_tag="I6I94_RS02530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02530"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_126926542.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.7e-38, bitscore:
                     128.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQSAFETQIQAEQQAYLQEVEAEMARFFTQQREMLSNISPDAL
                     SLLAAIEALSTGGKRLRALLSYWGWRGAGGVSILEDPKPLSVVRIGVAIELFQSAALIH
                     DDIIDRSDTRRGAPAVHKRFENQHKSSAWRGDTFNYGLTGGIIAGDLCLSWSETMFART
                     GVGSLPDRTARTVFDTMRTEVMAGQYLDVLSEVIDSEDYDAALQRAQNVIRYKSAKYSC
                     EHPLTLGGALALDAQQNQHHPILNAYHSFGLPLGEGFQLRDDQLGVFGEPETTGKPAGD
                     DIREGKRTVLVALTEKNADQAGRSLLETCLGNPNLDVHDVQRVRGLMLSCGAVAQLEEL
                     IARKSAAIDTALAALPVPEQVREALEAIAAKALHRAA"
     gene            complement(11246..11614)
                     /db_xref="GeneID:93861132"
                     /locus_tag="I6I94_RS02535"
                     /old_locus_tag="I6I94_02535"
     CDS             complement(11246..11614)
                     /codon_start=1
                     /db_xref="GeneID:93861132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888853.1"
                     /locus_tag="I6I94_RS02535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02535"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_006888853.1"
                     /transl_table=11
                     /translation="MSSEKTVQTFALVGDWVTIPDIAEALDLKVTRVHNLISDGTLVAL
                     REPDTNVRKVPALFLNGDHVLESLKGTLVVLKDAGFSDEEAITWLYTADDSLPGRPIDA
                     LINGQKTEIRRRAQALAW"
     gene            11810..13360
                     /db_xref="GeneID:93861133"
                     /locus_tag="I6I94_RS02540"
                     /old_locus_tag="I6I94_02540"
     CDS             11810..13360
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:93861133"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013398831.1"
                     /locus_tag="I6I94_RS02540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02540"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_128087629.1"
                     /sec_met_domain="Pkinase (E-value: 1.7e-44, bitscore:
                     149.2, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPPPSSTPSSSPASSATRGRDWLNGIIFDEHYLAGPLIAGGGMA
                     EVYYATDTWLNDSPVAIKILKPELAASPENQRKFYSEESSLRQMGGGHVIGVLSSGEQT
                     VRGQKLRYIVMEYVHGCTLGQLLRERGALSVGEALQILLPVVEGLSEAHARRLVHSDIK
                     PGNILLDVTETVKLADFGLTRRDDQALTGEIMGTPAYAAPELVKGQQTGAPADIFALGV
                     MMYLMFAGHLPFDGIANSSEVHRYNANVEIPPVAEAAPGLDPGLAGLISWCTRQQPEDR
                     PENALEVLTDLRDVTAHMSEEELAWRTPLVEEPEVPLWEAVEHIAETTGLAQMVHNSPI
                     SGIGRAEDLLVGTNRRAQPAKPVLPMEEYVPLSIGIGPETRPVNPALARGDIPLGGQRS
                     LDGSSARMHYGALRPELAQRSPNNVFGLPRTPPGPNRSPQRRPASHPQARPGPRPFPRN
                     RRLPAERLGPPPSPFTVVTGVVVLLVALVLAGFVGWLLAQSVLQSTWWANLSQMFGGL"
     gene            complement(13446..14834)
                     /db_xref="GeneID:93861134"
                     /locus_tag="I6I94_RS02545"
                     /old_locus_tag="I6I94_02545"
     CDS             complement(13446..14834)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:93861134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888865.1"
                     /locus_tag="I6I94_RS02545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02545"
                     /product="class II 3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_128087628.1"
                     /transl_table=11
                     /translation="MSNTIRPQQPSDHGLDIWRTLNADQQPTWADHPDYAPTVAELEKL
                     PPLVFAGEVDSMRHQLAEVAEGRAFLLQGGDCAETFAGATADKISGRVRTILQMAAVLT
                     YGASMPVVKMGRIAGQFSKPRSSDVETRDGVTLPSFRGETVNGHEFTAEARTHDPKRML
                     RGYHTSSATLNLVRAFTKGGFADLRSVHQWNRGFTENPAHARYEETAREIGRALKFMEA
                     CGVDFNALTTTDLYVGHEALVLDFERALTRIDSRTHQPYDTSAHFLWIGERTRGINDAH
                     VDFLSKVRNPIGVKLGPSTTTDDALALIDKLDPEREPGRLTFITRMGAKNIREKLPALV
                     EGVNASGAKVVWVTDPMHGNTISVPSGIKTRRFDDILDEVRGFFEVHESLGSFPGGIHV
                     EMTGDDVTECLGGSDPVDEAALANRYESLCDPRLNHSQSLEIAFLVSEYLKSQYVRQLG
                     NTMR"
     misc_feature    14966..14979
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.03"
                     /tool="antismash"
     gene            complement(15023..15784)
                     /db_xref="GeneID:93861135"
                     /locus_tag="I6I94_RS02550"
                     /old_locus_tag="I6I94_02550"
     CDS             complement(15023..15784)
                     /codon_start=1
                     /db_xref="GeneID:93861135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888851.1"
                     /locus_tag="I6I94_RS02550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02550"
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="WP_006888851.1"
                     /transl_table=11
                     /translation="MVTHPATTPVYAVLKAISDPTVRRIWPHEVIGAENMPNGPAIIAS
                     NHLAFCDSVFIPLAVKPTVNFLAKSDYFTTPGFKGRAMAAFFRSVGQLPMDRSGGEKSR
                     ASLEAGLKVLRAGGVLGIYPEGTRSPDGRYYRPKIGVARLALESGAPVVPVGQLGTDLI
                     QPAGTNRPRFRHNGKPITVRTIIGKPLEFAHLQDKANDHATLRAVTDQIAEAIRALSGQ
                     QYVPVPADKVKRLMAAHGWSAQTAVASLLTH"
     gene            16061..16900
                     /db_xref="GeneID:93861136"
                     /locus_tag="I6I94_RS02555"
                     /old_locus_tag="I6I94_02555"
     CDS             16061..16900
                     /NRPS_PKS="Domain: Abhydrolase_1 (53-154). E-value:
                     1.5e-14. Score: 46.2. Matches aSDomain:
                     nrpspksdomains_I6I94_RS02555_Abhydrolase_1.1"
                     /codon_start=1
                     /db_xref="GeneID:93861136"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888837.1"
                     /locus_tag="I6I94_RS02555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02555"
                     /product="carboxylesterase"
                     /protein_id="WP_126499823.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3e-14, bitscore:
                     51.2, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.1e-09, bitscore: 35.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIFENSLEPVRRIRRKVHERQQTGGVPAQQPDFNHEPLSSPADP
                     KKYAGDLGILIVHGFTGSPHSLHPLAAYLAEKGYPVELPRLPGHGTHWRDMAVTHYTDW
                     IDSVEQAYERLTGAGYRVIVIGMSMGGCLAAHLAARRPVAGTVLINPFFVDVNPLMRIA
                     HRVAPVLPVMRSIGSDIAVPGVDEGAYARTPTASIRQLHLLGVETRELLPKLHAPVLYL
                     RSVSDHTVTDASHRYFLQHVSASVEFKWLTRSYHVATLDYDAELVKEFTHKFVQSLS"
     aSDomain        16220..16522
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I6I94_RS02555_Abhydrolase_1.1"
                     /evalue="1.50E-14"
                     /label="I6I94_RS02555_Abhydrolase_1.1"
                     /locus_tag="I6I94_RS02555"
                     /protein_end="154"
                     /protein_start="53"
                     /score="46.2"
                     /tool="antismash"
                     /translation="ILIVHGFTGSPHSLHPLAAYLAEKGYPVELPRLPGHGTHWRDMAV
                     THYTDWIDSVEQAYERLTGAGYRVIVIGMSMGGCLAAHLAARRPVAGTVLINPFFV"
     gene            16920..18998
                     /db_xref="GeneID:93861137"
                     /locus_tag="I6I94_RS02560"
                     /old_locus_tag="I6I94_02560"
     CDS             16920..18998
                     /NRPS_PKS="Domain: AMP-binding (36-469). E-value: 5.6e-87.
                     Score: 283.9. Matches aSDomain:
                     nrpspksdomains_I6I94_RS02560_AMP-binding.1"
                     /codon_start=1
                     /db_xref="GeneID:93861137"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888843.1"
                     /locus_tag="I6I94_RS02560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02560"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_128087627.1"
                     /sec_met_domain="AMP-binding (E-value: 2.5e-87, bitscore:
                     290.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVFSVPAEVMCDPQLNITSILERRCADTTNPLLYRWQMSPGNWQ
                     PVRAREFRAMVVAVAKGLIASGIVPGDRIGIMSRTRFEWTLIDFAIWYAGAVSVPVYET
                     SAPAQAAWALSHSEAKAVFVEDDKLAGVIEQANSIEPLHLENTWVINNGALDALITAGL
                     NVPEEAVYTARDTATCSSLATIVYTSGTTGRPKGCPLTHGHFLNLSVNTKLAEPEIANP
                     HNSSIIFLPLAHVLARLIQILAMDAGVQIGHSPNIKNLAADLDSFKPTMLLVVPRVFEK
                     IYEGAKAKAAKGGTLNKALFDRSVKVAVEWSRAKISGRVPLALAAQYTFYDRLVYAKLR
                     AAMGGQLKYAVSGGGPLSDTLGHFFHAVGIRVVEGYGLTETCAPIAAGRISEFQIGAIG
                     PLLPGAQGRIAEDGELQVRGVGVIDGYYKNPQEDATAFTEDGWFKTGDLARFDERGNLT
                     IVGRKKEIIVTAGGKNVVPSVAEDHIRTSPLVSQAMLVGDQKPFIAALVTLDPDTLPEQ
                     LEHLGLPRAMSIPEAAVHPKVREAVQMFIDEANLLVSRAEAVREFRIMNKDLTEADGYL
                     TPSQKLKRSKILKDFSAYVDDMYSRVSSDMGVRLERLQEIKEQASEKLHEYAEQASERI
                     EELREQASERLQGYQAARAQKTESTEQVETTAVTSDGPKDTAVIEAAEDDTSRSHEQ"
     aSDomain        17028..18326
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I6I94_RS02560_AMP-binding.1"
                     /evalue="5.60E-87"
                     /label="I6I94_RS02560_AMP-binding.1"
                     /locus_tag="I6I94_RS02560"
                     /protein_end="469"
                     /protein_start="36"
                     /score="283.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="WQMSPGNWQPVRAREFRAMVVAVAKGLIASGIVPGDRIGIMSRTR
                     FEWTLIDFAIWYAGAVSVPVYETSAPAQAAWALSHSEAKAVFVEDDKLAGVIEQANSIE
                     PLHLENTWVINNGALDALITAGLNVPEEAVYTARDTATCSSLATIVYTSGTTGRPKGCP
                     LTHGHFLNLSVNTKLAEPEIANPHNSSIIFLPLAHVLARLIQILAMDAGVQIGHSPNIK
                     NLAADLDSFKPTMLLVVPRVFEKIYEGAKAKAAKGGTLNKALFDRSVKVAVEWSRAKIS
                     GRVPLALAAQYTFYDRLVYAKLRAAMGGQLKYAVSGGGPLSDTLGHFFHAVGIRVVEGY
                     GLTETCAPIAAGRISEFQIGAIGPLLPGAQGRIAEDGELQVRGVGVIDGYYKNPQEDAT
                     AFTEDGWFKTGDLARFDERGNLTIVGRKKEIIVT"
     CDS_motif       17466..17525
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I6I94_RS02560_0001"
                     /evalue="2.10E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="I6I94_RS02560"
                     /protein_end="202"
                     /protein_start="182"
                     /score="23.3"
                     /tool="antismash"
                     /translation="ATIVYTSGTTGRPKGCPLTH"
     CDS_motif       18156..18230
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I6I94_RS02560_0002"
                     /evalue="1.20E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="I6I94_RS02560"
                     /protein_end="437"
                     /protein_start="412"
                     /score="17.8"
                     /tool="antismash"
                     /translation="GELQVRGVGVIDGYYKNPQEDATAF"
     gene            complement(19161..20597)
                     /db_xref="GeneID:93861138"
                     /locus_tag="I6I94_RS02565"
                     /old_locus_tag="I6I94_02565"
     CDS             complement(19161..20597)
                     /EC_number="1.8.1.15"
                     /codon_start=1
                     /db_xref="GeneID:93861138"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888907.1"
                     /locus_tag="I6I94_RS02565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02565"
                     /product="mycothione reductase"
                     /protein_id="WP_128087626.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.7e-40, bitscore:
                     135.0, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIKDLEVIDGVAQYDLVVIGSGSGNSIIGPEWDDKTVAIIDGGI
                     FGGTCLNVGCIPTKMFVYPATVAVKTQEVAELGVEASVQNISWQNMRDRIFPHRIDKIS
                     EAGRQWRANLPNVDFYPEYAHFTGRHTLQTASGRKIHGKQVVIAAGSRATRPDVPGINL
                     PQVLTNDTVMRMEHLPQRMVVLGGGVVAAEFAHVFSALGVEVTQANRSARLLRGVDEEV
                     VNRFAQAASQQWNLLLEHSLIEIRQNDDDSVTVVLENDGELVDVVADKVLVATGRRPNS
                     DSLHAEKFFDVDARGLIGVDEYQRVLYNGAPVEGVFALGDISSPYQLKHVANHEARIVQ
                     HNLSHPNELRASDHRFVPAAVFSHPQLAYVGLTEEQARAAGEREGFEVTVKSQEFGDTA
                     YGWAMEDKVGLCKLIARKDTGQLLGAALVGEESSVLIQPLIQAMSFGLGVREMARGQYW
                     IHPALTEVVENALLGLEINA"
     gene            complement(20719..21039)
                     /db_xref="GeneID:93861139"
                     /locus_tag="I6I94_RS02570"
                     /old_locus_tag="I6I94_02570"
     CDS             complement(20719..21039)
                     /codon_start=1
                     /db_xref="GeneID:93861139"
                     /inference="COORDINATES: protein motif:HMM:NF012584.5"
                     /locus_tag="I6I94_RS02570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I6I94_02570"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_126853880.1"
                     /transl_table=11
                     /translation="MKEPQKVKDFFMPQNSNSPQRPNEHTLHSNQDDLGPTIVCAPFAG
                     YLTLLVGQGEHVDAGQKLAIVEALKVETLVTARTHGRVGRITHTDGSYVTGGQLLLTIV
                     PE"
ORIGIN
        1 ccggctgtac gatattcgcc aggtactcaa tattgcctac atggtcggca cccatttcaa
       61 taaccaagta ccgggtggtt tcatccgcac ggaataccgt cagcggcacc ccaacctcac
      121 cgttatagga gcccacggga gccaccgtag caccctcggc accaaaaata gctgccagca
      181 agtctttggt ggtggttttc cctgcggaac cagtaatccc aatgacttcc acgggaccaa
      241 gactacgcat cttctcgata gcgtatgccg ccaagcgccc catcgccagt accgcatcat
      301 ccacctgcac ggcaggatac agctcacctg aaggctcagc ggtaacgggc cgctccacaa
      361 gggctaagga agcaccagag ttaaaagccg cggcaacaaa acggtgcccg tcggtacttt
      421 ctcccggttt cgcaataaaa agggtaccgg ggactacttc ccgtgaatca gtagtggcga
      481 aggtacagaa gaccgtctcg gggtcttgaa gcccgagcgc ggcacctccg gtcgcctgga
      541 taatctcggc ggcacttagt ttaatcatta tttcttatcc tcagcgtttt cttccagcat
      601 acgccgataa tctggcagaa tctcaaatcc gcgagtaacc atggcgcggg ccacttcaat
      661 acggtcatcc agctgcacgt ctaccccagc tacatcttgg gctgtttcat ggccgcggcc
      721 cgcaatgagc acggcatcgt caggggtggc catatcgatg gcctgcgcaa tagccctagc
      781 acgcggggca atattatgta cttcatgagc ccgcgcccca gcggcgatag cttgctgcgc
      841 accggcagca acagcctcgc gaatgggggc cgggtcttcc ccatgcggat cgtcatcggt
      901 cacaataaca atatctgcgt agcgggcagc gatctcaccc atgatggggc gcttgccttg
      961 atcacgttca ccggtagcac cgaacacgat aatgactcgg ccctcaccgg ggcggtccat
     1021 cgcctctaac gcacggatta gcccgtcagg attatgcgca aaatcaacaa tagtgtgggg
     1081 gctgtgccca ataagctgca ttcgaccagg aactaccggg gtgagtgcct ccccactggc
     1141 gagcgcagcc gccaacggct ctctctcttc ttcgcttgtg ctgagccagg ccataagcgc
     1201 cgccagggcc gcattggaaa cgttaaaatc tgcgggaagt ccggtacgag cctgaacacg
     1261 ctccccagcc ccgttagcaa gtacgaaggt atgccctaac ccttgagcca tcacctcagt
     1321 gacagcccaa tcgttgacac caaaatctgc cggtaccgct tctaacccgg caccgtgatt
     1381 ggtcagcaac cgaattgtgt tttgcgcacc cagctgctgt tgtgcgcgaa caagcatccg
     1441 ctgcccccat ggatcgtctg cggtgatcac ggcccgttca gtacgttcag gggtgaacag
     1501 ctgtgctttt gagtcaaagt attcttccat cccaccgtgt aggtctaggt ggtcttgggt
     1561 gaggtttgtg aaaccactca ttgcataacg caccccgtca acgcggcgat aatcaatggc
     1621 gtgggaagag acttccatag ctgcacaacg tactccacgc tggcccatga gagacagcag
     1681 ggcgtgcaca tgcacagatt cgggggtggt catcgcggag ggaatcgaca caccgtcaat
     1741 aaggatttgg atggtaccga ccaacccggt tttgacgccc agagcggcac ggaaaacgga
     1801 ttcaagcata taggtggtgg tagttttccc gtttgttccg gtcaccgcga accgctgcag
     1861 ttgcgggtag tcgtttgaac cgtagatgaa agccgccaag gaacccagca cccggcgtaa
     1921 atctgtgcca ataataagcg cagtatctgc taaatcaagg tgcgcctcag caataatgcg
     1981 ctgcccctga gcgtcagtaa gaatacccgc tgcgcctgcg gctacagcag ctgcagcgaa
     2041 actagctccg tgtgttttag cacctggcag cgctacatat agatccccct cgcgtacgga
     2101 gcgtgagtcc atactgatac cggtcacgtt tcgggaaccg gatagggcta ggtgcggctg
     2161 tgcctcaagg ttttgcagct tctgaatgag cgtatctagc gggtagcctg tggttaggcg
     2221 gggccgtaag ttctgggcat ctttgccgaa cagctcttcg ccgggcatag cttcgtctga
     2281 gagtttctca ccgggctgtt cgccgttcat tgtccttctt ccttcgcgca tggggcgccc
     2341 tatttatcgt cttgtgatgt gccacagctg ggctggggcg attggtacct tctcattgta
     2401 atgagccaac gggtgctcgg caccctcacg agactagccg ctgttcttac catccgcaaa
     2461 aatggggata atatgtggct cggtggtgga gtgcggaata ttgtaggtgt gcagaactcg
     2521 ctccatgatt tgggagaatt gcccggtgcc gccgatagtt cccacctcac ctttggggcg
     2581 ctgcagggtg atactcacca taaaccgggg gttctcaatg ggtgctacac caatgaaaga
     2641 tgtggtgtat ccctcatagc cgcctttttc gctgggcgcc tctgcggtac cggttttacc
     2701 cccgacacgg tacccgttga cctgggcaag tttcgcttgc cccttagtca ccacattctc
     2761 catgagggtc aggcagtctc gggcggtttt ttcactcacc acacgctggg cgccctctac
     2821 gggaacctta tgctcggtgc cgtcggggtc gataatcgca tccacaatcc gtggcttcac
     2881 tttaaccccc aggttaccta cggcttgaaa aaccatagcg gtctgaagcg gggtctgtgc
     2941 aaggccctgg ccgaaaaaca ccgtgaattc ctggcgtccg tcccaggttt tccaatcgga
     3001 gactaggccc tgctgctccc cggcaatatc aatacctgtg aactcgccca taccgtattt
     3061 tttcagccac tcatagcgct cttctttggg catcttctgg ccaaccagca cagttccggt
     3121 gttcatcgaa tcggtaataa tacccgagaa cgtgcggcgt tgcgcggggt gctcaaaagc
     3181 atctttgaag gtttgcccgt taacggtgag ggtggcgggc acatcatatg tatcggtggg
     3241 ggtggtaatg cctttctcaa tgagcgctga tgcggtgagg attttctccg tcgatccggg
     3301 ctcaataatc tgagaaatgg cacgtggcac catatcttgt gtgttctcaa ctttttcggc
     3361 gcccgggtcc atcgttgttg aatcagcaag tgccaggatt gagccgtcgc gtacatccat
     3421 cacaatggcg catccccatt ctgctttgag ttcgtctaca cgggctttca taacctgctg
     3481 ggcgtagtac tggatatccc ggttgagggt cagacgcacg gttttaccgt tcactgattc
     3541 gctcacctgc tcctgggtca caggaatacg cacgccgtcg gccccgatct cgtacacgcg
     3601 tttgccgttc accccagcga gttccttctc gaaggtgcgc tcaatcccta ccgagaggtt
     3661 gcgttcaacg gtttcgtttt ctttaccctc aactgcttca tcaacgatgc ggtagcgacc
     3721 taccacagaa ccacccaccg gcccgtcggg gtacaggcgt tcgctgatta cttccccgaa
     3781 gaggaacggc gcccctaatg cgtcgatacg attgtaaatt tcgggggtta cgttggtttt
     3841 aatgaccgaa taccgggagt ctccctcaag ttttgacttc acgaagtcat cggtgatggt
     3901 cgggtccacg gtgcgcaaaa tatcggtgac ctcgtacacc agctcggtgg gggtgactgt
     3961 cacacgctct tgggagtggt cgtaacgttt aaattccgcc acgatcgtct ggtccgcgat
     4021 gatattgtac ctttgcacac tacgggccag tacatgcccg ttcacatcgg taatctgccc
     4081 gcggactgcg ggaactttct gggttcgggt tcgagaatcc cgggaggttg cagccaggtt
     4141 ttgcgggtca agcccctgaa cgtacagtag acgtaaactc agcaggccaa gtagccccgt
     4201 gctgctggcg cctatcatga atccacgtcg gctgagttta cgctcgctct gtgaggatac
     4261 cgcttttttc ttgtgggcca cagtgttcct tccggtacat tcctgcgcta tttcctggat
     4321 tgttgttcct atatcgccgg gctcttctgg cacctgccgg ggcagcttat aacttgcccc
     4381 gaacagaaca ctaccccgag tagattaggt gacaccaatc ggcgccaccg cccctacccg
     4441 gggtgtgaac tgtattagcg attcgcggag gcgctaggcg cagcctgtga tggctgagcc
     4501 tgctgcgggc tctgtgaacc ctgcggagat gcagagggtg aaggcgaggc ggcagcactt
     4561 gccttctcct tttcctgctt ctctttctct tcccgctcac ggttctgctt cgcggttttc
     4621 tcctgcgcct gcttctgggc atccgcagcc ttctgcccgg aggggtcatt atcgcgggtc
     4681 gcgggtgctg gcaccagatt cccgcgggtc ccattagctg aggtgggcga agcagctggg
     4741 gttggggtgc cctgaatcgt accgttctgc acgtccaaag ttgccggggt ggtgctgggg
     4801 aacatattca gcagagaagc acggatcgct agatcctgcg gagcttcgtt gtaccccagc
     4861 tcctgatgca gagcctcgtt ctgctgggtg agagccagct cctgggcgtg catgtctacc
     4921 agttcgtact gacgctgagc cactaggata ttcatcagta ggttaaagat gagaaatagc
     4981 gggatcacca aaaacaccgc ccacatcaga aggctcatga tgcctccccg gcgggtgggt
     5041 ttacgtaaag aacgggccag cggcgcacgt ttttttgcac cggaggcttc acgcacttca
     5101 gcgcgcccag ctgtaccgcc ccgagcaggt ttaggccgcg ccgaggtggt attcgcttcg
     5161 aactgcgcgg ttgagggctt ctcaaatact cccgctaccc cgcgcgtgta cgccaagaaa
     5221 cgggcaggag cgtctagcag ggtcgccccc cgggaggtgc gcatggcacc agcgccctga
     5281 gaccgggctg tttcggttgt tcgagcccgg ctgggggtgc tggttcgggt ggtgctgcca
     5341 gcggtagcag cccgagatga tgcaccaact ttttccttct gtgcggtgcg gcgggtgctt
     5401 gtcgaagttg tggaggcacg acgagccgac ccggggtgtg aggagcctgc tcggcccggc
     5461 gcagcagctg tcccttccgg gcgtgtttta cgacccgggg gtttgggcgt gttcctacgc
     5521 tcccccgtca tggtggtctt cgttgttacg ctcatttatg taaccctaat cttctcgcca
     5581 gcccgcaatt ttgcgcttgc ggcgcgtgaa ttctctgcga tttcagcctc agtcggtggc
     5641 tctgcgccac gcgtgataac tttcatcgtt ggcttatgtt cgtcaagctc cacggggaac
     5701 cctttgggcg ccttagaggt ggcggcagca ctcaggcccc gcttgacgat cttgtcttct
     5761 aaactgtggt agctcatggc cacgaaccgc ccgcccaggg agagcgagtc gattgcgacc
     5821 ggcacagcgc gttccagtgc ctccagttcg tggttcacct caatgcgtag cgcctggaaa
     5881 gtgcgtttcg cagggtgccc gcccttgcgt tgtgccgctg ctggcaccgc cttttggata
     5941 gcggctacca gctcaccggt ggtctcaaac ggctgaacgg cccgctgagc aacgatccgt
     6001 tcggcaatcc gcgcggcgaa cttctcttcg ccccacgtgc ggataattct ctgcagccgc
     6061 tccagcggat actcgttcac tacggtgcgt gctgtcagct catcttcact attcatccgc
     6121 atatcgagcg gagcgtcgta agaataagca aacccgcgtg aacgctcatc cagctgcata
     6181 gaggagacac ccaagtcgaa taggacgcca tcgacggcat tcaccccggc gacatccatg
     6241 gcgtattcaa tctggtcgta cacagcgtgc acggggatga accgctcgcc gaaccgctcc
     6301 agccgctgcc ccgcaatagt gtgcgcctgc gggtctcggt cgataccgat cacctgcagt
     6361 tcggggaaac gttcaagcat tgcctcggtg tgcccgccca ttcctaacgt cccatcaatg
     6421 accactgccc cttcacgttc gagggccggg gctagcaggt caaggcacct ggtaagcata
     6481 accggtacgt ggcgttcttt cgcttctttc ttcgaaagcc ccgcatcggg agtttcagta
     6541 agcgtaaggg tgtgtgcggg agctaccgct ccctgagcac cggcgtgggt gctttcctta
     6601 gcgctcatat tcgctccttg agggtcacgt actaggatct gctcccgcag cgaatgcgct
     6661 aacagatggg gtggtttaca ggaaggggaa aggctcctca tccagttgtg caaattcagc
     6721 ttcggtacga gcaaggtact cgtcccaagc ctgagcgtcc cagatttcgg ctcgggaacc
     6781 cgcgccgatg acgacaagct cgcggtctaa ccgagcgtac tcacgcaacg ccgccgggat
     6841 ggtgacccgc ccctgcttat cgggcacctc atcagatgcg cccgacagga acacacgcat
     6901 gtagtcccga gcctgccgtg aagacagtgg cgctgaacgc atctgctcgt gaatacgctc
     6961 aaactcttcc gcagagaaca cgtacaagca acgttcctgt ccgcgggtga gcactagacc
     7021 agcagaaagt tcctcacgaa atttcgcggg aagaatgatg cgccctttgg tgtctaaccg
     7081 aggcgaatac gtccctaaaa acacgtaccc accccctcac agcgcacttg aacaatctgc
     7141 taccctccac tttaccccac tttccaccac ttaacccttt ttaagcaccc aaattttccc
     7201 gcaaatttta ataaacctgc acgtcaagcc cttgaatccc gcagcttcac cccagatagg
     7261 accgttattg aggagttcgc cacccgctga ttcgacgcac gaatagccaa catattttga
     7321 aaaaccacat cattgcccgt tccacgcagg cagttttaga gttattggcg gcagcagaca
     7381 caatcccgcc gctacacggg ttattgtggg gcggtggagg attgtggagg gaaaagtgga
     7441 ggaaacatcc tcagtttcag cgtgagtacc gcttacggtg gggaaaacac ccataatcag
     7501 aagctaacgc tagcttggga taaataccgg ctcttagtac caccaccccg gtgtggcatg
     7561 tacagtagct gcaagtacag cgacctttaa cggacagtgg ggcggggcct cccttatgga
     7621 agccccgccc caccaccaag tctgaggtag aacacggttt aaacgtacca gcctattacc
     7681 acggtggtac ctcacgccag cactgacgta tcacaagaag aaaaatatac taacgcccct
     7741 gttcgcgctc atcccagcgc tcttccaggc gctccatgag cttcgattgt ttgcgctgtt
     7801 gctgcgcctt ctcagcggag gcacctttag ccttaccacc taagaacgaa tcaatagggg
     7861 ttttcttact ggtggtcgca aaatacacgc ccccggcggc aactataaag ccgacaatac
     7921 caagcagaat aatctttgag gcaaccgccc caataataat gcccagccca gcaagcacgc
     7981 acaggatacc cagcaccatg tggcgggcgc taaatacggg cgcggtattg cccgtcgaag
     8041 acatcgaact tgcaaactgc gggtcttcgg cgtgcattaa ctcctcaagc tgatcaagga
     8101 ctttctgttc gcgctccgaa agtgccatag cattctcctt aaaaccgtgc ccaaaagccc
     8161 tgccgtcggc acatatccac cccggggcaa gaccatcaca tgtagcctag cgtacgttca
     8221 tcatagtacc ccttttaggc ccccaatagg tactctttct tgagctaaat ctctgtgtat
     8281 gtactgagaa taaaagccgc actcaccaca tccctgcgtt gccgcggatg catcagagta
     8341 cccagcggcc catgaacctg cctcaacgct taacactcag gggatttcta agccgtatat
     8401 tctttaaaag ctcgcacttc tacgcctctc atcctgcctt acccctgacg atgctgcacc
     8461 ctgtgcatat gtgttcgccc cgccgtatac cccatcagag aggccgggcg caccgcctct
     8521 gcactaaatc gcgtatggat gccgtcaagg gcacgctcca cacgacccca gtcagctttc
     8581 tctgcaccgt caccttcctg tgggtccaag gcaaaaagcg tctgctgcac accagaggcg
     8641 cattgttgca gccgctcggc gcgtacccct atcaaccgta aagcccgtga cgcttgttcc
     8701 ttttgaccat cacaactttt gatcaaaagc cccatcgccc tcagggcggc gcaagcaata
     8761 cgatatatct gcatcccaga atctacaggc tcagttaggg gtatagattt agtgtgtgtc
     8821 tcaaaacctt cataacgata tttaatggtc agcgcaccgg cggttttccc tgctgcgcgc
     8881 agccgccgcc ccaaccgtaa agcaataccc tgcaccgctc gctcaatatc tgcgacgcag
     8941 cgagtatcgg cagcaaaggt atgttcagct cccatacttt tctcaacacg ttcagtgacc
     9001 accggacgat gatcaatacc acgagcaaga gcatagagat ggttccctgc cgcattacca
     9061 aaacgcccgc acagccactg ggcgtcaaat tcacgcagct gtgccaccgt gtagattccg
     9121 tattcgttca gcaaagtggc gcttcgcgcc cccacacccc acagtttatt aaccggcata
     9181 ggatccagga actcctgcac cctgtggggt ggcaccaccc acagcccatt gggtttactg
     9241 ccagttgagg ccattttggc aagaaactta ttaatagata tccccgccga gcagggtaga
     9301 gacagctcgt ctgcaatacg ttctcgcacc cgctgtgcta tcgcaaccgg ggatccgccg
     9361 atggcagtgg caccggtgag atcaatgaat gcctcatcaa cacttacttg ttccacaagc
     9421 gggctttcat cccgcagtat tcgcatgacc gcacgagagt aaaagccgta atcaccccgc
     9481 agaggcagaa tagttgcctg tgggctcagg cgtttagcac gtgccagcgg catacccgaa
     9541 tgaacacccg agtctcgagc ctcataggaa gcagaacata ccactgagcg cgggccctca
     9601 tgcgccacaa taataggagt tccgtgtaat tctggtttat tcagcagctc tacgttgaca
     9661 aaaaatgcgt ccatatcaag atgcatcatg atgcggggct tctcgcttcg gtcatcagcg
     9721 gtattccccc gctggaagcg agatgtatta aagatgtttt ttacgttctc agacattcca
     9781 cccccttgat agagggaggc cctggatgac tattgtgcct cagctttgat gtatcttcag
     9841 cctcccacca ccccataata gcatatatat tctatatagt attcttgttc tataaaaaat
     9901 cgagttggct agccccacgc gaaaataccg cgaattatgg gagatagcat aagctagatg
     9961 ggtatcgacc accgccagat atatatcgac gggagcaaca atggctacgc agagcgcgtt
    10021 tgaaacgcaa attcaggccg aacagcaggc atatctgcaa gaggttgagg ccgaaatggc
    10081 gcgttttttt acccaacagc gcgagatgct ctccaatatt tcaccagatg cactcagcct
    10141 gttagcagcc attgaagcgc tctccacagg tggtaaaagg ctgcgtgcgc tactgagcta
    10201 ctggggatgg cgcggcgcag gtggggtgag tattcttgag gacccaaagc ccctgtcggt
    10261 ggtgcgtata ggggtggcca ttgaactgtt tcaatccgct gcgctcatcc acgacgatat
    10321 tattgaccgt tccgatactc ggcgtggagc acccgctgtg cacaagcgtt ttgagaacca
    10381 gcataaaagt agtgcctggc gcggcgatac ttttaactat ggtcttacgg ggggtattat
    10441 cgccggagat ctgtgcctat cgtggtcgga gacaatgttt gcgcgcacgg gggtgggctc
    10501 cctaccagac cgcaccgcac gaactgtttt cgatacgatg cgcaccgaag tcatggccgg
    10561 gcaatacctg gatgtgctct cggaagtcat cgattccgaa gattatgatg cggcactaca
    10621 gcgtgcccag aacgtgatcc gttataagtc agccaaatat tcatgcgagc acccgctgac
    10681 tcttggcggc gctctagccc ttgatgcaca gcagaaccag caccacccca ttcttaatgc
    10741 gtaccacagc ttcggcttac ccctgggtga aggctttcag ctgcgtgatg atcagctggg
    10801 ggtgttcggt gagcctgaaa ccactggaaa acctgccggg gatgatattc gggaaggaaa
    10861 acgcaccgta ctggtggcac ttacggaaaa gaatgcggat caggcgggac ggtccctgct
    10921 tgagacatgc ttggggaacc cgaacctaga tgttcacgat gttcagcggg tgcgtggtct
    10981 catgctttct tgtggtgcag tggcgcagct tgaggaactc attgcccgca agtctgctgc
    11041 cattgatacg gcgctggctg ctttaccggt accggagcag gtacgggaag ccttagaagc
    11101 tattgcagca aaagcgctgc atcgagccgc gtaactgtaa aaggtggagg ggaccactcc
    11161 atcatgcggg tggcccctcc accgtcacta gtttgagaaa agcgcccaag tactcaacgg
    11221 cgcgcggttt tatcggactt gggttttacc aggctaaggc ctgtgcgcgg cggcggattt
    11281 ccgtcttctg cccgttaatg agcgcatcaa tgggacgtcc cggcagagaa tcatccgcag
    11341 tgtagagcca ggtgatggct tcctcgtcgc taaaaccagc gtctttgagc actactaagg
    11401 tgcctttgag agattcgagc acatgatcgc cgttgagaaa aagcgcgggt actttacgca
    11461 cattcgtgtc tggttcgcgc agggctacaa gagtgccatc tgagataagg ttgtgcactc
    11521 gagtaacttt caaatcaagt gcctcggcaa tatcgggaat agtgacccag tcacctacaa
    11581 gggcaaaggt ctgtacagtt ttttcgctac tcacctttta agagtgccag aatctaccca
    11641 attttgccta cttatgcgcc gccattattg ccggttctgt tatggtgtgt ggtccgggct
    11701 ctattacttg gccggtttta ccctctttac ctatgaatcc gctgtatctt tgctcagtga
    11761 gagttgtcca tgcagcatgg acaccacata tcccctagaa tcgtagataa tgaatcctcc
    11821 cccatcttca acaccatctt cttcccccgc gagttctgcg acgcgggggc gtgactggtt
    11881 aaacggcatc atcttcgatg aacactactt ggctggcccg ctcattgctg gcggcggtat
    11941 ggccgaagtg tattatgcga ccgacacatg gctcaacgat tccccggtgg ctattaaaat
    12001 tctgaaacct gaactggctg cttcgccaga gaatcagcgc aagttttaca gtgaagagtc
    12061 atcgctacgg cagatgggcg gcggacatgt gatcggcgtg ctttcctcag gtgaacagac
    12121 ggtacgcggg cagaagctac gatacattgt catggagtac gtgcacgggt gtactctagg
    12181 ccagctgctg cgggagcgcg gtgccctatc tgtgggggaa gccctgcaaa ttctactgcc
    12241 ggtagtggag ggactgtctg aggctcatgc gcgacggctg gtacacagcg atattaaacc
    12301 cggcaatatt ttgttggatg tgaccgaaac ggtgaaactg gcagacttcg ggttgacgcg
    12361 ccgcgacgac caggcactca ccggtgagat tatgggcacc cccgcatacg ccgcaccgga
    12421 actggtcaaa ggccagcaga cgggtgcacc cgccgatatt tttgccttgg gcgtgatgat
    12481 gtacctcatg ttcgccgggc atctgccgtt tgatggcatc gccaacagca gcgaggttca
    12541 ccgttacaat gcaaacgtcg aaatcccgcc cgtcgcggag gctgctcccg gcctagatcc
    12601 agggcttgcg gggctcatta gctggtgtac ccgtcagcag cctgaagacc gtccagagaa
    12661 cgcgcttgaa gttctaaccg atctgcggga tgtgacggcc cacatgagcg aggaagagct
    12721 tgcctggcgc actcccctcg tggaggaacc tgaagttccg ctatgggagg ctgtggaaca
    12781 catcgctgag actacggggt tggcccagat ggtgcacaac agccccatca gtggtattgg
    12841 ccgtgctgag gatctgctgg tgggcactaa ccggcgggcc cagcctgcaa aacctgtgct
    12901 gcccatggaa gaatacgttc cgctctcgat cggtatcggc cctgaaaccc ggccggtaaa
    12961 ccctgcttta gcgcgtggcg atatccctct gggcggccag cggtccttgg acggttcctc
    13021 ggcgcggatg cattatggcg cgctgcgccc agagcttgct cagcgttccc cgaataatgt
    13081 ctttggactt ccacgcaccc caccgggccc taaccgttcc ccacagcgca ggccagcatc
    13141 gcatccgcaa gcgcggcccg gcccgcgtcc tttcccccgt aacaggaggc tcccggctga
    13201 acggctaggt ccgccaccgt caccatttac agtagtgacg ggagtggtcg tactcttggt
    13261 ggccctagtt ttggcagggt tcgtggggtg gctgctggcc cagtcggtat tacagagcac
    13321 gtggtgggct aacctgtcac aaatgtttgg tgggctctaa tcccccacac ctcatacgtt
    13381 caaggccgat gggctgccct ctttaggacg gctcatcggc ctcatcatac gttatgtggg
    13441 tgtgcttaac gcatagtatt acccagttgg cgcacgtact ggctcttcag gtactcagat
    13501 accaagaatg cgatctccag agactgtgaa tggttcagtc gcgggtcgca cagcgattcg
    13561 tagcggttag ccagtgctgc ctcatccacg gggtctgagc cgcccaaaca ctcggtgacg
    13621 tcatccccag tcatttcaac gtggatgcca ccggggaaag agcccaggga ctcatgcacc
    13681 tcaaagaagc cgcgcacctc atccaggata tcgtcaaacc ggcgggtttt aatccccgat
    13741 ggaaccgata tagtgttgcc gtgcatgggg tcggtaaccc acacgacctt cgccccggat
    13801 gcattaaccc cctcaacgag agcgggaagt ttttcacgaa tgttctttgc ccccatgcgg
    13861 gtgataaaag taagacgacc gggctcccgt tcagggtcga gcttgtcgat aagagctagt
    13921 gcgtcatcgg tggtggtgct ggggcccagc ttaacaccga tggggttacg caccttagag
    13981 aggaagtcta cgtgggcgtc gttaattcct cgggtgcgtt cgccaatcca caaaaagtgt
    14041 gcggacgtgt catacggttg gtgggtacgc gaatcgatgc gtgtgagggc acgttcaaaa
    14101 tcaagcacca gtgcctcgtg gcccacgtac aggtcggtgg tggtcaacgc gttaaagtcc
    14161 accccgcagg cttccataaa tttgagggca cggcctattt cacgcgcagt ttcttcatag
    14221 cgggcatgcg cagggttttc ggtaaacccg cggttccact ggtgtacgga acgcagatcg
    14281 gcaaaaccgc ccttcgtgaa agcccgcacc aggttcaggg ttgccgagga ggtgtggtac
    14341 ccgcgcagca tccgcttggg gtcgtgagtg cgcgcctctg ctgtgaactc atgaccgtta
    14401 acggtttctc cacggaacga aggcagggta acaccgtcac gggtttccac atccgaggag
    14461 cggggtttag agaactgccc ggcaatgcgg cccatcttaa ccacaggcat agaggcccca
    14521 taggtcagca ccgctgccat ctgtaggatg gtgcgaacac ggcctgaaat tttatcggcg
    14581 gtggctcccg cgaacgtttc ggcgcagtct ccgccctgaa gcagaaaagc acgaccttca
    14641 gcgacttcag caagttgatg gcgcatcgag tctacttccc ccgcaaagac cagcgggggc
    14701 agcttttcga gttctgccac tgtgggcgcg tagtcgggat gatccgccca ggtaggctgc
    14761 tggtcagcat taagggtgcg ccaaatatcc agcccatggt cgctgggctg ttgcgggcga
    14821 atcgtgttgc tcatgtatgt tgtctcgctc tatcactcag gttgggttgt ctgcggttgc
    14881 ggtaccccat agctaaaacc atgaggcagt actacgttat tgtactcccg ctatgggcaa
    14941 gacggtacgg agcggtcatg tttttatctc gctgcgtgaa atcacacgcc acaaagcggc
    15001 ccgtacaacc gaaatgtggc tgttagtgtg tgagaagact agctactgcg gtttgggcgc
    15061 tccacccatg agccgccata agccgtttaa ctttgtcggc gggcacaggc acgtactgct
    15121 gccccgagag ggcgcgaata gcctcagcaa tctgatcggt cacagccctg agcgtggcgt
    15181 ggtcattagc tttatcctgc aaatgcgcga actccaacgg tttaccaata atagtgcgta
    15241 ccgtaatggg tttcccatta tgccgaaaac gtggcctgtt cgtcccggct ggctgtatta
    15301 ggtcggtgcc cagctgaccc acaggtacca cgggcgcacc agattccaat gcaagacgcg
    15361 ccaccccaat tttagggcgg tagtagcgtc cgtcaggact gcgggttcct tcagggtaga
    15421 tgccgagcac tccccctgca cgaagtacct ttagacccgc ttctaaagaa gccctgcttt
    15481 tctccccacc cgaacgatcc ataggaagct ggcccacgct gcggaagaaa gctgccattg
    15541 cacgcccttt aaagccgggg gtagtgaaat agtcgctttt cgctaagaaa tttacggtgg
    15601 gtttaaccgc aagcggaata aacaccgaat cgcagaaggc taagtggtta ctggcaataa
    15661 tggctggacc attgggcatg ttttcagcac ctatgacttc atgcggccag atccgccgga
    15721 cagtggggtc gcttattgct ttaagtaccg catatacggg tgttgtggcg gggtgtgtga
    15781 ccacagtttt ctcctggagt gtttccggtt attgaacgcg gcacggttcg attaattcac
    15841 accggtgtgc gtcatcggag gggcgagtgc cttcctagta gattgtagcc gggtaccagg
    15901 gggtccattg ggtgttatac agcccatttt cacctgccag ttacctgtga atcgcacgaa
    15961 atcacgctca cagctcaata gcgtgagttt ttatctcacc ttgaaagcaa taatagtgct
    16021 agatattaag tgtggggtta cacagcttcc tgggggatgt atgaatattt ttgagaactc
    16081 gttagagccg gtgcgtcgga tacgccgcaa agtacacgag aggcaacaga caggtggggt
    16141 gcctgcgcag cagccggact ttaaccacga accgctgtcg tcccccgcag accccaaaaa
    16201 gtatgcgggt gacttaggta tcctcatcgt gcacgggttc acaggctctc cgcacagtct
    16261 gcacccgtta gcagcgtatt tagcagagaa agggtacccg gtggagttac cccgcttacc
    16321 cggccacgga actcactggc gtgatatggc agtcacccac tacaccgatt ggatagatag
    16381 tgttgagcag gcgtacgagc ggctcactgg tgcgggatat cgagtaattg ttatcggtat
    16441 gtctatgggt ggatgccttg ccgcgcacct tgcggcacgc cgcccggttg ctggcacagt
    16501 gcttattaac ccgttctttg ttgatgtcaa cccgctcatg cgcattgccc accgggtggc
    16561 accagtgctg ccggtaatgc gctcaatagg gtccgatatt gccgtgccgg gtgtagatga
    16621 aggggcatat gcacgcactc ccaccgcgtc tatccggcag ctgcacctgc tgggggtaga
    16681 aacccgcgag ctactgccga aactgcatgc acctgtactg tacttgcgct ccgtatcaga
    16741 ccacaccgtt actgacgcgt cacaccgcta ttttctgcaa catgtctcgg catcggtaga
    16801 atttaaatgg ctcacccgta gctaccatgt ggcgaccctt gattacgatg ccgagcttgt
    16861 taaagaattc acacacaaat ttgtacagtc cttaagctag ggcgtggaag gcgtaactca
    16921 tgaaggtttt ctctgttcca gcagaggtaa tgtgcgaccc gcagctgaat atcaccagca
    16981 tcttagaacg ccgttgcgct gacactacca acccgttgtt gtatcgctgg cagatgtcac
    17041 cggggaattg gcagccggtg cgggcccgcg aatttcgggc catggtggtg gcggtggcta
    17101 aagggctgat cgcctccggt attgttcccg gagatcgtat cggcattatg agccgcaccc
    17161 ggttcgaatg gactctcatt gacttcgcta tctggtatgc gggagccgtc tctgttcccg
    17221 tgtatgagac gagcgcgccc gcccaggcgg cgtgggctct ttctcactcc gaagcgaaag
    17281 cagttttcgt tgaggacgat aagctggctg gtgttatcga acaggcgaac agcattgagc
    17341 cgttgcacct tgaaaacacc tgggttatta ataacggggc cctggatgcg ctcattacgg
    17401 ccgggctcaa cgtgccggaa gaagcagtgt atacggcacg tgacaccgcc acctgcagct
    17461 ccctggcaac tattgtgtac acctcaggta ccaccggcag gccgaagggg tgcccgctaa
    17521 cacacgggca tttcctgaac ctgagcgtaa acaccaaact ggcggaacca gagattgcga
    17581 atccccataa ttcctctatt atttttctgc cgttggcgca tgtgctcgcc aggctgattc
    17641 agatattggc gatggacgcg ggcgtacaga ttgggcattc ccccaatatt aaaaacctcg
    17701 ctgccgatct ggacagtttt aaaccgacta tgctgctggt agtgccccgc gtgtttgaga
    17761 aaatctatga gggggcgaag gctaaagcag ctaaaggcgg aacgctcaac aaagccctat
    17821 ttgaccgctc agtgaaggtt gctgttgagt ggtcgcgcgc taaaatttcc ggtcgggttc
    17881 ccctcgcgtt ggcggcccag tacacgttct acgataggct cgtgtatgcg aagctgcgag
    17941 cggcgatggg cgggcagcta aagtacgccg tctcgggtgg tggcccgtta tccgatactc
    18001 taggccactt cttccacgct gtaggtatcc gggtggttga agggtacggt ctcacggaga
    18061 cttgcgcgcc gattgcagcg gggcgtatta gcgagttcca gatcggggcc atcggcccgc
    18121 tcttaccggg agcgcagggg cgtattgccg aagacggcga actgcaggtg cgcggcgtgg
    18181 gtgtgatcga tggatactat aagaaccctc aggaagacgc caccgcattt actgaagacg
    18241 gctggtttaa aaccggggac ctggcccgct ttgatgaacg cggcaacctg acgattgtgg
    18301 gccgtaagaa agaaattatt gtgactgcgg gcggtaaaaa tgtggtaccg tccgtggcgg
    18361 aagatcacat ccgtacctcc cccttggtat ctcaggcaat gttggtggga gatcagaaac
    18421 catttattgc cgcgctggtg acgcttgacc cggatacgct gccggagcag ctggaacacc
    18481 tgggcttacc gcgtgccatg agcatccccg aggcagcggt gcacccgaag gtgcgtgagg
    18541 cagtgcagat gtttattgac gaggcaaacc tgctggtgtc tcgggcagag gcagtgcgtg
    18601 aatttcgcat catgaacaaa gacctgacgg aagccgacgg ttacctgacg ccatcgcaga
    18661 agcttaaacg ctcaaagatt ctgaaagatt tctccgcata tgtggacgat atgtacagcc
    18721 gggtctccag cgatatgggt gtgcgtctag agcggctgca ggagataaaa gagcaggcgt
    18781 ccgagaaact gcacgaatac gcggagcagg ccagcgaacg cattgaggag ctcagggagc
    18841 aggccagtga gaggctgcag gggtatcagg ctgcgcgagc gcagaaaacc gaaagtaccg
    18901 agcaggttga gacgactgct gtgacctctg acggccccaa ggataccgct gtgatcgaag
    18961 cagcagagga tgacacttct cgctcccacg agcaataagt tcggccttgg gccggaacgg
    19021 tcgggtgccg catgtacgca atgtgcgctg acggctgcca ggtatatgtt tcccagaaga
    19081 tgtatgccgc agggcaggct ttcccaccga gtctcctcaa accgggaaaa cttgccctgc
    19141 ggcatatttt gcagctatag ctatgcgttg atttcaagcc ccagcagagc gttctcaaca
    19201 acttcagtca gtgcggggtg aatccagtac tggccgcggg ccatctcgcg cacccccagc
    19261 ccgaagctca tcgcttgaat gagcggctga atgagcacgg atgactcctc gcccaccagc
    19321 gccgccccca gcagctgacc ggtatcttta cgggcgatca gcttgcacag ccccacttta
    19381 tcctccatcg cccagccata ggcggtatcc ccaaactcct ggcttttaac ggtcacctca
    19441 aagccttcac gttcaccggc ggcacgcgct tgctcctcgg tgaggcccac atacgccagc
    19501 tgcgggtggc tgaacacagc cgcgggcaca aagcggtggt cgctggcgcg tagctcattc
    19561 gggtgggaca ggttatgctg cacgatgcgc gcctcgtggt tagcaacatg tttaagctga
    19621 tatggggagg agatatcccc cagcgcaaaa acgccttcaa cgggggcgcc gttgtacagt
    19681 acccgctgat actcgtccac accaataagg ccgcgggcat ctacatcaaa gaacttctca
    19741 gcatgcaggc tatcactatt tggacgccgc ccggtagcca ccagcacctt atcggcaacc
    19801 acatcaacta gttcgccgtc gttctcaaga accacggtta ctgagtcgtc atcattttga
    19861 cggatctcga tgagagagtg ctccagcagc agattccact gttgagatgc ggcttgggcg
    19921 aaacggttca caacctcctc atccacgccg cgcagcaggc gggctgaccg gttcgcctgg
    19981 gttacctcaa cgcccagcgc tgagaaaaca tgtgcgaact ctgcggccac taccccgccg
    20041 ccaagcacca ccatacgctg cggtaggtgt tccattcgca tcacggtatc atttgtgagc
    20101 acctgcggca ggttaattcc gggcacgtcg gggcgcgtgg cgcgtgaacc ggcggcgata
    20161 accacctgct taccgtggat cttccggccc gatgcagtct gcagggtgtg ccggccggta
    20221 aagtgcgcat actctgggta gaagtcaacg ttcggcaggt tagcacgcca ttggcggcca
    20281 gcctcagaaa tcttatcgat tcggtgtggg aaaatgcggt cgcgcatgtt ctgccacgaa
    20341 atgttttgca cggatgcttc aacgccaagc tcagcaactt cttgcgtttt aactgccacg
    20401 gtggccggat acacaaacat ttttgtgggg atacacccca cgtttaggca ggtgccgcca
    20461 aatataccgc cgtcaataat ggcgactgtc ttatcatccc actcgggtcc aataatgcta
    20521 ttgcccgacc cagagccgat cactacaagg tcgtactgtg ccaccccgtc aatgacttcg
    20581 aggtctttaa tgctcatgcg ctcctacctt tatcatgtgg tggtcccggg cctgccggtt
    20641 ctcgggtttg ccagtttctt gggcctcagg tgcccttcgt atcattctaa cggtagctat
    20701 aacacgggga cttaggtttt attccggcac tatagtcagt agcagctgcc caccagttac
    20761 gtatgagcca tcggtgtggg taatacgccc aacccgaccg tgcgtccgag ccgttaccag
    20821 agtttccact ttaagggctt cgacgatggc gagcttctgt cccgcgtcca catgctcgcc
    20881 ctgacccacg agcagagtca ggtacccggc gaacggtgca cacactatag tgggccccag
    20941 atcatcctgg tttgagtgta gagtatgttc gtttgggcgc tgcggcgagt tgctgttctg
    21001 cggcatgaag aagtccttta ctttctgcgg ctctttcata tccaacggct acagggcggc
    21061 gacaagcccc gtgagcaggc gggtgaaacg ggttgccggg tccacggctt cctcatcggg
    21121 ccagtaatgg atag
//
