LOCUS       NZ_CP064192            24130 bp    DNA     circular CON 30-JAN-2024
DEFINITION  Saccharothrix sp. 6-C chromosome, complete genome.
ACCESSION   NZ_CP064192
VERSION     NZ_CP064192.1
KEYWORDS    RefSeq.
SOURCE      Saccharothrix sp. 6-C
  ORGANISM  Saccharothrix sp. 6-C
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharothrix.
REFERENCE   1  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Saccharothrix texasensis strain 6-C
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2020) College of Life Sciences, Chongqing
            University, University Town Road, Chongqing, Chongqing 401331, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 10:20:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,916
            Genes (coding)                    :: 7,819
            CDSs (with protein)               :: 7,819
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 41 of 97
            Pseudo Genes (incomplete)         :: 78 of 97
            Pseudo Genes (internal stop)      :: 6 of 97
            Pseudo Genes (multiple problems)  :: 27 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:34:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6481003
            Orig. end                         :: 6505133
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP064192.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24130
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="35"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24130
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24130
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14130](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14130
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(58..2892)
                     /locus_tag="IOD16_RS27210"
                     /old_locus_tag="IOD16_27075"
     CDS             complement(58..2892)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022063.4"
                     /locus_tag="IOD16_RS27210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27075"
                     /product="Z1 domain-containing protein"
                     /protein_id="WP_201436640.1"
                     /transl_table=11
                     /translation="MNPDHRKAMEIALTLLDYEDDVTASVVARAVDQALRAIGQANVDV
                     DKLRRDVESRCNVWLPTEQVLNGHEDHVPWLDVARGEIEWNFWDRYRRYLGRKGWAPAQ
                     IRSIDQVTDRILGSFEKPDRPGRWDRRGMVVGQVQSGKTANYTGVICKAADAGYRLIVV
                     LAGLHNSLRSQTQHRLDMEFLGFDTRSNRSYDQTNAKVGVGQMKGKFLHVHSLTSSDEK
                     GDFQVKVARQVWLNAGGSDPVILVVKKNASVLRNLHLWATRLNQELDPETGQQTVRNVP
                     LLVIDDEADNASVNTKARPTDENGQPIDDYDPTKINGLIRKLLRTFEKSAYLAYTATPF
                     ANIFIDADEKTDKYGEDLFPRSFIINLRPPSNYVGVNTVFGLDSDVNSGIEGQPGLPII
                     STFDDHEMWLPNKHKKDTVPGRLPASLLTAINAFLLATAARRVRGHEDHNSMLVHVTRF
                     TDVQALVRRALHEHVDLMRQRVWHGDPTSPDSPWPALESLWRTDFVPTTEALLRIPDLT
                     SEVGAVIDWAQIRDALPGVLDDVELRVLNGKSEDALTYSEADRPLTLIAIGGDKLSRGL
                     TLEGLTVSYYLRASKMYDTLMQMGRWFGYRPGYLDLCRLYTTDELAGWYRDIALANEEL
                     LREFEYMAALGKTPQEYGLRVRAHPDGLMITARTKMRNGTDVDITFSQTISESITFETD
                     EDVLRNNLAATERLVNAMGVPKSRQGDLGNIKWEGVPAPDVLDFLDEYQASDVATKAQP
                     RALAEYVRTLLTTKKPELTTWTVVLVSVSGKDKKTFKIGDLEVGLAQRGLFLSKEGLYA
                     DDEYKAGLRAGRDRYVIRRLVSPGDEKLDLSEDEGDRALELTKQAWQLDPKTRTSAPSV
                     PGGLFIREVRPPSRGLLLLYPLMPDAWMHPDLPPVGFALSFPRSRTAKTIKYRVTNLWW
                     DQEFGSQDSDEEQS"
     gene            complement(2889..4382)
                     /locus_tag="IOD16_RS27215"
                     /old_locus_tag="IOD16_27080"
     CDS             complement(2889..4382)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024977.4"
                     /locus_tag="IOD16_RS27215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27080"
                     /product="ATP-binding protein"
                     /protein_id="WP_201436641.1"
                     /transl_table=11
                     /translation="MTGYEIVEPRAESLVESLRAFGYATETAIADLVDNSITAKATTID
                     VRLRWAGNESWIAIVDDGLGMDGERLREAMRPGTTSPSTPRKASDLGRFGLGLKTASFS
                     QCRRLVVMSVTVTSSLAARTWDLDHVVRVGGWQLLTELTTEDRRLWEELHGDKPGTVVL
                     WRQLDRLVVSPDPQNVQAEKHFYTIADRVAKHLGMTFHRYITGPGQITIRVNGRNVVPW
                     DPFLESHETTQVVTDESLPYRSELIKVKSFVLPHVSRMTSRDHIIAGGPRGWASQQGFY
                     IYRNRRLIVSGSWLGLGFRREELTSLARIRLDLPNHMDSDWQIDVRKSVARAPGALVPE
                     LRRIAEVVRLRSANVYRHRGKVLQRASQGDVVQAWLQVVRGTKIAYQINREHPLVAALL
                     TTAGGGDVEAMIRLLEETVPVPLIILNHADGPGRQAAPFEETAPDAVRSVLTDVARAMR
                     RTGTSGKEIVGRLLTMEPFSDFPDLVREVCTRELGQEMA"
     misc_feature    complement(5123..5137)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    complement(5133..5146)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     gene            5204..7090
                     /locus_tag="IOD16_RS27220"
                     /old_locus_tag="IOD16_27085"
     CDS             5204..7090
                     /EC_number="2.1.1.37"
                     /GO_function="GO:0003886 - DNA
                     (cytosine-5-)-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012372.4"
                     /locus_tag="IOD16_RS27220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27085"
                     /product="DNA cytosine methyltransferase"
                     /protein_id="WP_201436642.1"
                     /transl_table=11
                     /translation="MSIYGVKLQRSDDLRLARHPDGCTEHTFEQWCAQKLAAGQRLAVD
                     LFSGAGGLSLGLEEAGWTVAVSVDNDEKAVQTHSHNFPGLVLDLDLGEPSQRQELVELL
                     SRTEIDLLAGGPPCQPFSRAGRSKIRSLVVAGHREEHDHRRELWQAFLDVALAVRPRAV
                     LMENVPDMALGDDFAVVRTMVDALERSGYYTEFRLVDAWRYGVPQHRKRLIVLARLDVE
                     EFAWPAEQSKQPTLRDAIGDLPELGDTTGGRELPYSKPRRLSAFAETMRVGARNGVVWD
                     HMTRPVRDDDRTIFGMMDASTLYADLPEDLRRYSAETFDDKYKKLDWESVSRSITAHIA
                     KDGYWYIHPQELRTLTVREAARVQTFPDRFRFAGTRSDAFRQIGNAVPPLLGRAAAAAL
                     RPVPTHERSEERLGEVSRWIEARQALTSWAKQQQRGPSWHALPGQGVTPAVAAVAALLM
                     SRSNAPRGTDRALATIRGRTRLTKAELDQMQHELPTQAGRQVLERFRPLLPKRKLWTDP
                     EALIEHLAMKAAEERTFRLLVGEDVLLANQATLRVAARVAGSGSDRTNRLSDGRVDLAR
                     LVGAGPDAPLRAAALRLLGSTVCKAPSTVCGDCPLRQQCVGSSSERAVQTLF"
     gene            complement(7209..7589)
                     /locus_tag="IOD16_RS27225"
                     /old_locus_tag="IOD16_27090"
     CDS             complement(7209..7589)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151812.1"
                     /locus_tag="IOD16_RS27225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27090"
                     /product="hypothetical protein"
                     /protein_id="WP_201436643.1"
                     /transl_table=11
                     /translation="MPASNTEGGRIFREAWIAGVRKHYPGEPKPGYVAAWEDTPDWERA
                     SAAAVYSQVLAFLTITAGQAAKLTRTQKGQFIAACWTGQIHRHFSDPKPSYVANWDELP
                     AWQQETDADIFERIEQDHVAGD"
     misc_feature    7603..7623
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.75"
                     /tool="antismash"
     gene            complement(7653..8879)
                     /locus_tag="IOD16_RS27230"
                     /old_locus_tag="IOD16_27095"
     CDS             complement(7653..8879)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="IOD16_RS27230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27095"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_201436644.1"
                     /transl_table=11
                     /translation="MSDPSPGDVLRAERQRRRLTLAQAGKLLGYSGSALSRIERGRPVD
                     TDTLRRLADRYGIHPQRLGLATVGPADPLNGGDDVLRRELLAGVLGVAGAALLGLPDAH
                     AQSTTTGPVTVDELRRLVDRIQADYLACRYSQLAAGLPQVIRHAQATRAAVDAEQRGEV
                     DALMATAYRHATWLALRLGEDGLATGLSDQALSAARASGNLLVEAEAAQMGAVVLRRFE
                     QPDKAQHLVVDTAGKLHSDAGLASSGYGAAYAMLLETGAYTAAIAGRRDTALELHAEAT
                     TAARTTRTALPTALTPSAVDARYLGLYEISVHRKLGDYGTAIEAARAIRPGTITVTERL
                     VRYWEDVALTFGAWGKREQAFHALLAAERAAPQEIRLRPWAHRLTRQLRSSGPSLPGLR
                     EFAVRAGVA"
     misc_feature    complement(9042..9056)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.89"
                     /tool="antismash"
     gene            complement(9436..9663)
                     /locus_tag="IOD16_RS27235"
                     /old_locus_tag="IOD16_27100"
     CDS             complement(9436..9663)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS27235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_27100"
                     /product="hypothetical protein"
                     /protein_id="WP_201436645.1"
                     /transl_table=11
                     /translation="MSDVEVSGRSALAGGRWNAGETSGVGVVQDMTGDTDTTFERWPHR
                     SMSAALDFVVGPVAAWRSLALITSFFRLAG"
     gene            9780..9932
                     /locus_tag="IOD16_RS27240"
                     /old_locus_tag="IOD16_27105"
     CDS             9780..9932
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="IOD16_RS27240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27105"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_201436646.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 3.2e-14, bitscore:
                     51.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTALQDAPVGAFDLDVRIETEQVGVEDAACATDDGCGHTCELSA
                     CHSQR"
     gene            10001..12985
                     /locus_tag="IOD16_RS27245"
                     /old_locus_tag="IOD16_27110"
     CDS             10001..12985
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="IOD16_RS27245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27110"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_201436647.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.6e-174,
                     bitscore: 579.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.3e-11,
                     bitscore: 43.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-20, bitscore:
                     73.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCADKGFVHYQHHGTGLLRATAEVIDIRRWPDPDDEQDCRSWLVE
                     AWPLPGIAPAIRHASPVLATRVETILSGDAVAARDVRRATLSVVRYVLRARGRPTPFGT
                     FAGVSTLAVGTSTDARWGTGHRPVVRAETRWLHRVVQRLEDCAELVARLDVTLNDAAEL
                     RAGRWELPGPRKVSVRATSAVAMVRDEAAVPIGFGVLSDKLAHAFPEAGDASAMLMSLL
                     RNGLLLTSLRATGTVTNPLAFLVERLRDAGADSLPIAPLAEELNRIHRAITEHNHTPSE
                     QARVDLASRMREVADSVRVPLSVDLRLDAHVQLPQQVVREMQRAAGVLARLTRETTGSR
                     EWREWFAAFCERYGTGTLVPLRMVMDRDGGIGLPRGYPGSPRLAHRHVVSARDELLLAL
                     AAEATALGQREVELDEALAEKLAAASGERGTPPPHVDLGARIHAANAAALDRGEFTLTV
                     SPGRAAGTLTSRFTTLVPEAGLAAIFAALPTTTAGAAPVQLSFSPIYPAAENVCRVPAY
                     LPDVVSIGEHVPDGAIRVDDLAVTATHRRLHLVDLSRRRVVEPQVLHALAPKQQPAMAR
                     LVGELTRALDVGWIGFDWGAADALPFRPRVRYGRAILSAARWRLVQTDLPMNPAEWDQA
                     LHSWRTTWRCPARVELRDFDQLLPLDFDVSAHRKILYRHLRKHSEAVLLEAADPDADGW
                     LSGHPHTVVLPLTSLRVPEPAPAVEVLPILTREHGHLPGSSWLYAKLYLSASRMDHLLV
                     HELPALLAALGDRACWFVRYPQAREGEEPDQLRLRVRAHGDKPGDTDRILIAVTSWGDR
                     LRAEGLIGRLAFDTYFPEVGRYIAIKEAEDVFTADSHLVLAQLAHLTADAVAPAVLTGL
                     SMFDVAAAFLGGPAAAADWLSTQATPAAPDRAEVNEVTRLVRDGWQPGIPGWSAVSEAH
                     RQRADALARYRRALPDGVDIDRVLHSLLHMHHNRALGVNRDREAICLRLARQAAAAWRT
                     TQDIA"
     aSDomain        10463..10702
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IOD16_RS27245_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="8.10E-14"
                     /identifier="RREFam001.1"
                     /label="IOD16_RS27245"
                     /locus_tag="IOD16_RS27245"
                     /protein_end="234"
                     /protein_start="154"
                     /score="43.1"
                     /tool="antismash"
                     /translation="VTLNDAAELRAGRWELPGPRKVSVRATSAVAMVRDEAAVPIGFGV
                     LSDKLAHAFPEAGDASAMLMSLLRNGLLLTSLRAT"
     gene            12982..14130
                     /locus_tag="IOD16_RS27250"
                     /old_locus_tag="IOD16_27115"
     CDS             12982..14130
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="IOD16_RS27250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27115"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_201436648.1"
                     /sec_met_domain="LANC_like (E-value: 5e-36, bitscore:
                     123.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQRRGQVHDVKSARWAQSLADGAAGTALLHLELGEDAEEWLTA
                     MVAEPVLAHPHQATLFDGAPAVAFTLAATTHHRALAAVNEHVEAVIRARLDAAHRRIDS
                     GELPAKREFDLVSGLTGLGAYLLRRHGSTERHGAQLADVLVYLVRLTEPRPDGLPGWWA
                     TSGPTGPGPDWAGGHGNLGVAHGIAGPLTLLALAMRRGVVVPGHAEAVDRICRWLDHWR
                     RGSGHRLWWPGAITRTEHLTGALRSAGPHRPSWCYGTPGITRAQQLAALALGDIRRQRF
                     AQRALAWCLTDEAQLAQLSDVSLCHGWAGVLHTAWRVGEHDEQVRAHVPRLAERLTEHL
                     LHHPPPPHGLLNGEAGVRLAQRAATTDTTPITRWDACLLLDG"
     misc_feature    13867..13869
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14160..15407
                     /gene="fxlM"
                     /locus_tag="IOD16_RS27255"
                     /old_locus_tag="IOD16_27120"
     CDS             14160..15407
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="IOD16_RS27255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27120"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_201436649.1"
                     /sec_met_domain="PCMT (E-value: 1.6e-42, bitscore: 144.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSDTATDPTAETAASPEALRAEMVEKVRKAGYAQREEVERVLRD
                     TPRHEFVPEAGLKSAYNPWQAVITHRFEDGRSLSCASAPFVVAMMLDQLDVQPGNRVLE
                     IGAGTGYNASLLARLTGRADLVTTIDIDPDVTAQASRNLTTAGHADVHVITGDGGLGYA
                     DHAPYDRLIATVSPWDIPAAWWQQLAPGARLVAPLRWRGQARSVGFTYTDGRLVSDSIY
                     LCGFVYLVNADEGELSGPITADETVKLHWDRDQAIDLDALRGVLDQPRTTAWSGVTIAG
                     DESHDGIWLRLTVTDQRVCRIDAHSDVAPEVCDPIQAFRSPALVDGDSLAYLTSRRQTN
                     GDEVRWELGAIGHGPAAAELTEHLCDEIRAWTPERDRRKPTLIVYPVDMPDSELAGPAI
                     DKTHSRFVLTYDDVSG"
     gene            complement(15616..17145)
                     /locus_tag="IOD16_RS27260"
                     /old_locus_tag="IOD16_27125"
     CDS             complement(15616..17145)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015397.4"
                     /locus_tag="IOD16_RS27260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27125"
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="WP_201436650.1"
                     /transl_table=11
                     /translation="MIAKAPAKGKYGKDTYGLLRYLFGPGKSNEHTDPHLVAAWDPEWL
                     EGGAFAEHHRGWLARLAREIDAPRTGHEVDLEGGHVYHLVLSIPSQDGALGDARWRELV
                     EEAVDRMGFGPTDDGRAGCRWVAVHHGPSKDGNDHVHVAINLVRGDGTIADTYRNWPRW
                     RQWCLEVEQRLDLTRTSPANQTAPIRSTRAEVEKATRYRRADTNRDLLRTKVRTAAVEA
                     SSAREFIALLERDLQVAVQPRWGSDRQLTAYRVALRAEWEKASADGRIWFSGSSLAHDL
                     SAPKLTARWTSTRQPAQEQAEVRRAPEELLTRATQAVDNARRHLTGRVIAGDVSDGSGG
                     DDVAHATADMLVAVARALGGPEPGALAEVVVVYERAATAPRRGQPVWQTEVAAALRTTA
                     RDLFRAGILSKRNSTGLLAAALVLALIALLVQIAAWRQLSRQQAQATAATRAAARMNNY
                     SAYLAKRHPPTGRPEPLSFQPEPVHKPSSLSPPLARRPQHPQPDPTIRRTR"
     gene            complement(17142..17546)
                     /gene="mobC"
                     /locus_tag="IOD16_RS27265"
                     /old_locus_tag="IOD16_27130"
     CDS             complement(17142..17546)
                     /codon_start=1
                     /gene="mobC"
                     /inference="COORDINATES: protein motif:HMM:NF017524.4"
                     /locus_tag="IOD16_RS27265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27130"
                     /product="plasmid mobilization relaxosome protein MobC"
                     /protein_id="WP_201436651.1"
                     /transl_table=11
                     /translation="MTQRKTRRQRRVTGGSPVSIHVRTTVTTYAALVARAAVAGLSIPR
                     YLVESALRDSTTGWSLREQRWWAERLDTVETRLIRIGTNLNQMATVANSTGDLPPELPA
                     ALAYFTATLEQHRAVLAAIDPADSSREREL"
     gene            complement(17748..19007)
                     /locus_tag="IOD16_RS27270"
                     /old_locus_tag="IOD16_27135"
     CDS             complement(17748..19007)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024547.4"
                     /locus_tag="IOD16_RS27270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27135"
                     /product="DUF3987 domain-containing protein"
                     /protein_id="WP_201436652.1"
                     /transl_table=11
                     /translation="MTHSGESYEETNKTNELPPAPPAVDPTVFRGVLGELVMAADPTTE
                     ADPIGVLVSLMANVSAVIGTGPHVQIGNTRHPLIVWPLLFGRTGAGRKGDATETADRLT
                     WAAVPEVGHLFVSGLSSGEGLIERIRDPRDENDPGGTEDKRLRILEAEFGSVMARAKRE
                     GNTVGAVLREGWSGKALAVMNRLALRASSSHVVIIGHVTPREFRLRLAQTEMAGGTFNR
                     FLPVYVERSKRLPLPEGIAPEVLSELGARLREAVERAARHGEVGLDEEARRLWNEELYD
                     ELGCADDEEGAWTEFARRALPYCRRIAALYAVLDDRDQVDVKDLKAAAALVRYSIGTAK
                     FVLDRTLRNPRVDTLRRALDGVGEAGLGRGEVSALFGRNLTKQVLDELLHEVMATGEYT
                     EFRHSGERGRPSMRYRRAES"
     gene            complement(19004..19246)
                     /locus_tag="IOD16_RS27275"
                     /old_locus_tag="IOD16_27140"
     CDS             complement(19004..19246)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS27275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_27140"
                     /product="hypothetical protein"
                     /protein_id="WP_201436653.1"
                     /transl_table=11
                     /translation="MTDRRKLTNPGGRQCRTRRALTESQAATEAGLEAYVERIVRAAPP
                     FTASQRARIAAILNGSAPAAERANRPSIDHEDGRT"
     gene            complement(19243..19443)
                     /locus_tag="IOD16_RS27280"
                     /old_locus_tag="IOD16_27145"
     CDS             complement(19243..19443)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024139.4"
                     /locus_tag="IOD16_RS27280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27145"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_201436654.1"
                     /transl_table=11
                     /translation="MADKNIEPAYLSVGDAAGRLSVSEVTIRRAIRSGALAHVRIGRAV
                     RIAVADLDAYATARREGGEAR"
     gene            complement(19480..20202)
                     /locus_tag="IOD16_RS27285"
                     /old_locus_tag="IOD16_27150"
     CDS             complement(19480..20202)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS27285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_27150"
                     /product="hypothetical protein"
                     /protein_id="WP_201436655.1"
                     /transl_table=11
                     /translation="MGAGDNTRIVEERPPQRLAVPSSAVPDSYSVGEIRRAVNSLRALR
                     LTQAEPPDEGWPQGLAAGFEAFVERDDRIRARITAGHAKRLRLLRRADDLPYTVQEDLF
                     VLTGKALTTATPQDLGITVSYYPGSSRAQQEKVISDAEAVIQLIRLLLFWAALGARKYP
                     TALRALLLLIFGPRLVPHLLTWPASNAPPPRTQHPPGRLVLAEPRVARAPGRRWSLAAV
                     VQRGPRRAVHAWGSALTT"
     misc_feature    20280..20290
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    complement(20286..20301)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.17"
                     /tool="antismash"
     misc_feature    20304..20317
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.6"
                     /tool="antismash"
     misc_feature    20305..20318
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.29"
                     /tool="antismash"
     misc_feature    complement(20305..20319)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.66"
                     /tool="antismash"
     misc_feature    20306..20319
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.52"
                     /tool="antismash"
     misc_feature    complement(20307..20320)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 18.26"
                     /tool="antismash"
     gene            complement(20336..21073)
                     /locus_tag="IOD16_RS27290"
                     /old_locus_tag="IOD16_27155"
     CDS             complement(20336..21073)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS27290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_27155"
                     /product="hypothetical protein"
                     /protein_id="WP_201436656.1"
                     /transl_table=11
                     /translation="MWRTQAFDDGIKDARRRQQVWRTSEDLLTHRRETAYGIGNSGYQA
                     QYRAAESAARNALDAAVSAYNFLEDHPLADIAHQHAHAVGEFVGGIFGCWIRMYDGVYW
                     DECPATLMHHRWGFSPGYTSRRLCSICFEDIDDCPHLIGQKYEMIAARDDQGRCNCCGW
                     TDCSHVPGQSVEVNPVAIHGDIDLEEVSMVSRPRDPLARPTRISLDVEALGAVLDLDSS
                     EGILRCYRCVNSCEGFIDPSFDF"
     misc_feature    complement(20396..20398)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(21282..21788)
                     /locus_tag="IOD16_RS27295"
                     /old_locus_tag="IOD16_27160"
     CDS             complement(21282..21788)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS27295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_27160"
                     /product="hypothetical protein"
                     /protein_id="WP_201436657.1"
                     /transl_table=11
                     /translation="MEMVDPVTLAGVDPGTLLLLPDKIGKEGRALYRDDNAGLVKTIRA
                     EGASLEFAWPRDRRAYVSEFGAGEVIAAVTLGVVGNFTTDVIRYMYRIVQFRVAAALGR
                     PVLDGQEIDEVVTFKVARFESSPQRRVIEGLECSGPVSGVIDLIKSLVDSEVESFDGEP
                     DGQSE"
     gene            complement(22113..23618)
                     /locus_tag="IOD16_RS27300"
                     /old_locus_tag="IOD16_27165"
     CDS             complement(22113..23618)
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012464.4"
                     /locus_tag="IOD16_RS27300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_27165"
                     /product="recombinase family protein"
                     /protein_id="WP_201436658.1"
                     /transl_table=11
                     /translation="MDEAVGVYARISEDPLGLEKGVKRQVTDGVALCGQRGWTIYDTFV
                     DNDLSALRGGPRPEYDRLIEAAVAGKITRIVAFQMSRLWRNRRERAEAIEKLSKAGVSV
                     VLVKGSDIDLTSAYGRALAGLLGEFDTMESEVKAERVEAAARQRAEEGKANGAVAYGWR
                     RVKVRNSSGEVIDWYDEIEPEEAAIVREIVDRLLARESLNAITSDLNARGVPTPQGGGK
                     TWRTSSVRKLALRLANIARRARGRQDFGPAAWPPIIESDRHDQVTALLNDPSRVQTRGG
                     ARQHLLTFGIGRCGKPGCGTRLRVAQKWINPRHKELGKVPLYVCDSPSSCVGRRQSWVD
                     DLVERVVVRRLQEPDARDLLTRDDDKARAARERVETLRARLNGAADDYADGVIDREQMR
                     RITTTLRPELEKAEQDSMRAVQGIPPHILGDIIGPKARERWRDLQVTQKRALLEAMGVV
                     VTILPARGGAGFRPESVDVRFMSDRESAMADEMTAALTMSSRR"
ORIGIN
        1 gcgtgtcgtg cagctcgccc cagagctcct caagatcggt ggtggacggc accgcggtca
       61 tgactgctcc tcgtcggagt cctggctgcc gaactcctga tcccaccaca ggttcgtcac
      121 ccggtacttg atggtctttg cggttcggct cctcgggaag ctaagggcga accctacggg
      181 cggcaggtca ggatgcatcc aggcgtcggg catgagcgga tacagcaaca acagtccgcg
      241 actcggtggg cggacctcac ggatgaagag tccacccggc acgctcggcg cagatgtcct
      301 agtcttcggg tctagctgcc aagcctgctt ggtaagttca agagcccggt cgccctcgtc
      361 ttcggagagg tccagtttct cgtcccccgg cgagacgagc cgacggatca cgtagcggtc
      421 acgtccggct cgaaggccag ctttgtactc gtcgtcggcg tacaggcctt ccttggacag
      481 gaagaggccg cgttgcgcga gcccgacctc gagatcgccg atcttgaacg tcttcttgtc
      541 tttgccggag accgaaacga gtaccaccgt ccacgtcgtg agttccggtt ttttcgtagt
      601 cagcaaagtc ctgacgtact ccgccaatgc ccgcggctgc gcctttgtcg caacatcgga
      661 ggcctggtac tcatccagga agtcaaggac gtcaggcgcg ggcacgcctt cccacttgat
      721 attgccgaga tcgccctggc gggacttcgg gacacccatg gcgttgacga ggcgttcagt
      781 ggcggccagg ttgttgcgaa gcacatcctc gtccgtctcg aacgtgattg actcactgat
      841 agtctgcgag aatgtgatgt caacgtcggt accgttacgc atctttgttc tggcagtgat
      901 catcagcccg tctggatgtg cgcggacccg aagcccatac tcctgtggcg tcttcccgag
      961 agctgccatg tactcgaact cgcgtagcag ctcctcgttg gccagcgcga tgtcgcggta
     1021 ccacccggcg agttcgtcgg tcgtgtatag gcggcacagg tcaaggtaac cgggtcgata
     1081 accgaaccag cggcccatct gcatcagcgt gtcgtacatc ttcgatgcgc ggaggtagta
     1141 gctgactgtc agcccttcga gggtcagacc acgggagagc ttgtctccac cgatcgcgat
     1201 cagggtcagc ggtcggtcgg cctcgctgta ggtcagggca tcctcggact tcccgttgag
     1261 cacgcgcagt tcgacatcgt cgagcacgcc tggaagcgca tcgcggatct gtgcccagtc
     1321 gatcaccgca ccgacctccg aagtcagatc agggatccgc agcagggctt cggtggtcgg
     1381 tacgaaatcg gttcgccaca aagactccaa cgcgggccac ggggagtcgg gactggtggg
     1441 gtcaccgtgc cacacgcgct ggcgcatcag gtccacatgc tcatgcagag cccggcggac
     1501 gagcgcttgc acgtcggtaa agcgggtgac gtgcacgagc atcgagttgt gatcttcgtg
     1561 accgcgaacc cgacgtgcgg ctgtggcgag gaggaacgcg ttgatcgcgg ttagcagcga
     1621 tgccggcagt ctgcctggga cagtgtcttt tttgtgctta ttcgggagcc acatctcgtg
     1681 gtcgtcgaac gtactgatga tcggcagacc aggctgcccc tcgatgcccg agttcacatc
     1741 gctgtccagc ccgaaaacgg tgttcacgcc gacgtagttg ctcggtggcc ggagattgat
     1801 tatgaagctg cgcggaaaca ggtcctcgcc gtacttgtcg gtcttctcgt cggcgtcgat
     1861 gaatatgttt gcaaacggcg tggcagtgta agcgaggtaa gctgattttt cgaacgtcct
     1921 cagtagtttc cggatcagac cgttgatctt cgttgggtcg tagtcatcga tcggctgtcc
     1981 gttctcgtcc gtcggccggg ccttggtgtt gaccgaggcg ttatccgcct cgtcgtcgat
     2041 caccagcaat ggaacgttcc gtacagtctg ctgaccagtc tccgggtcaa gctcctgatt
     2101 cagccgggtg gcccacaagt gcaagttccg caatacagag gcgttcttct tgaccaccag
     2161 aatgaccggg tcactgccac ccgcattgag ccagacctgc ctggcgacct tgacctgaaa
     2221 atcgcccttc tcatcgctgc tggtcaacga gtggacgtgg aggaacttcc ccttcatctg
     2281 cccgaccccg accttggcat tggtctggtc gtagctgcgg ttgctcctgg tgtcgaaccc
     2341 gaggaactcc atgtccaagc ggtgctgagt ctggctgcgc agactgttgt gcagaccggc
     2401 caacacaacg atcaggcgat aaccggcgtc tgcggccttg caaatgacgc ctgtgtagtt
     2461 ggcggtcttg ccggactgca cttggccgac aaccattcca cgacggtccc acctgccagg
     2521 ccggtctggt ttctcgaacg agcctagaat ccggtcggta acctggtcga tgctgcggat
     2581 ctgagctggc gcccaaccct tccggcccag ataccgccga taccggtccc aaaagttcca
     2641 ctcgatttcg cccctggcga cgtccagcca gggcacatgg tcctcatgac cgttgaggac
     2701 ctgttcggtc ggaagccaga cattgcaccg gctctccacg tccctccgca gcttgtcgac
     2761 gtcgacgttt gcctgcccta tggcacgcaa cgcctggtcg accgcccgtg cgacaacgct
     2821 ggccgtgacg tcgtcctcgt aatcaagcaa cgtcagggcg atctccatcg ccttgcggtg
     2881 gtcggggttc atgccatctc ctgaccgagt tcgcgtgtgc agacctctct gacgaggtcg
     2941 ggaaagtcag agaacggttc cattgtcagc agccgaccta caatttcctt gccggatgtc
     3001 cctgtgcgtc tcatcgctcg ggcgacatca gtcagcaccg accggaccgc gtccggcgcg
     3061 gtctcctcga acggtgccgc ttgccggccc ggtccgtccg catggttgag gatgatcagc
     3121 ggaaccggaa cagtctcctc cagcagcctg atcatggcct cgacgtcgcc gccgcccgca
     3181 gtcgtgagca acgcggccac aagcgggtgc tcacgattga tctgataggc gatctttgtt
     3241 ccccgcacaa cctgcagcca ggcttggacc acgtcacctt gactggcacg ctgaagtacc
     3301 ttgccgcggt gtcggtagac attcgccgac cgcagccgaa cgacctctgc gatccgccgc
     3361 aactctggga cgagtgcgcc cggtgcccgg gccaccgact tgcggacgtc gatctgccag
     3421 tctgagtcca tgtggttggg caggtcgagg cggatccggg ccagtgaggt cagctcctcc
     3481 cgccggaatc cgagcccgag ccagcttccg gacacgatca accgtcggtt ccggtagatg
     3541 tagaacccct gctgggatgc ccagccacga gggccgccag cgatgatgtg gtcccgagac
     3601 gtcatcctgc tcacatgcgg caggacgaag gacttcacct tgatcagctc gctccggtac
     3661 ggcaatgact cgtccgtgac cacctgggtc gtctcgtggg actccaggaa cgggtcccac
     3721 ggcacgacgt tccggccgtt cacccggatc gtgatctgcc cgggacccgt gatgtaccga
     3781 tggaaggtca tcccgagatg cttggcaacc cggtcagcga tggtgtaaaa gtgtttctct
     3841 gcctgcacat tctgcggatc tggtgagaca acaagacggt ccagctgtcg ccacagcacc
     3901 accgttcccg gcttgtcacc gtgtagctcc tcccacagtc gccggtcctc ggttgtcagc
     3961 tccgtcagca gctgccagcc accgacgcgg acgacatggt cgagatccca cgtccgagcc
     4021 gccaacgacg atgtcactgt caccgacatg acgaccagcc gccggcactg cgagaatgac
     4081 gctgtcttga gtccgagtcc gaaccgcccg agatcactcg cctttctcgg cgtcgaaggg
     4141 ctggtggtgc ccggccgcat cgcctctcgg agcctttcgc cgtccatccc gagaccatcg
     4201 tcgacgatcg caatccagga ctcgttgcca gcccatcgca ggcggacgtc gatcgtcgtg
     4261 gccttggcgg tgatgctgtt gtcaaccagg tccgcgattg cggtctcggt ggcgtacccg
     4321 aacgcgcgaa gcgactccac caacgattct gcgcggggtt cgacgatctc gtagccagtc
     4381 acgtttccgc cacgtcaacg gtttccgctt catgcatgat ccgtagcacg accacgggcc
     4441 ccgtctcggc cgacagcctg gcaagaggcg gcgggtttgc gctgctgtcc accctccagg
     4501 aagcacctgt cgcacgggtg ggtgctcggg gtccaccccg cagttcagct gcctcttgtc
     4561 gcgagtcatc gtccagatac aaaggcagcc cacgtcgcgg gagcatgcgg tgtttcgccc
     4621 acgagcctgg agtgtctcct ccgcaaggcc gcaggcggcg acactgatcc tgcggaggtg
     4681 accacgagcc gcgatcggcg gcgccgtagg gccttcggac gtcgacgttc cactccgcag
     4741 caagcgctgc gaaccagctc agtgaagctg ggcccccgac cggatgcggg ttgacgatct
     4801 cgtagtaggc gttgttcatc tcaacccgcc accagccact acacccccgt ccgcgtctgc
     4861 tcggctcgac cgagccaccg acgcaccaag cttccccggg tcaaacgacc agcgtaagga
     4921 ggtcctacag gtccgtacgt accatctgcc cgtgggcgtc accagcacaa agagtgataa
     4981 cccagctcag cacaccgacc gactgttgcc gaaccgttac actggccgcg agcggtcctg
     5041 gccaggaatc gtcggacccc accgctatcg ttacagtcgt ccatcggccc cggtgacgga
     5101 cggcgactcg gcaccggaga tcatggacgt tgttgatcca ggacgacgtc tgtgttctcc
     5161 tggtgctcgt tgacgcagat gttcggggga aaggtacggg cgggtgtcca tctacggggt
     5221 caagctgcaa cgcagcgacg atctacgact tgcccgccac cctgacggct gcaccgagca
     5281 cactttcgag cagtggtgcg cgcagaagct ggccgctgga cagcggctcg ccgtcgacct
     5341 gttctccggt gccggcgggc tgagcctcgg gctggaggag gctggctgga ccgtcgcggt
     5401 ttccgtcgac aacgacgaga aggccgtgca gacacacagt cacaacttcc cggggttggt
     5461 gctggatctc gacctcggcg agccctcaca gcgtcaggag ctggtcgagc tactaagcag
     5521 gaccgagatc gatctcctcg cgggcggacc gccttgtcaa ccgttcagcc gcgccggtcg
     5581 cagcaagatc cgcagcttgg tggtcgccgg gcaccgtgag gaacacgacc accggcgtga
     5641 gctgtggcag gcgttcctcg atgtcgcgct agctgtacgg cctcgggccg tcttgatgga
     5701 aaacgttccg gacatggccc tcggtgacga cttcgccgtg gtgcggacca tggttgatgc
     5761 actggaacgc agcggttact acaccgagtt ccggctggtc gatgcctggc gttacggcgt
     5821 tccccagcat cggaagcgtc tcatagttct agctcgactt gatgtagagg aattcgcttg
     5881 gccagccgag cagagcaagc agccaacgct gcgcgacgcg atcggtgacc tccctgaact
     5941 cggcgacacc accggcggtc gcgagcttcc ctacagcaag ccccgacgtc tgtctgcctt
     6001 cgccgagacg atgcgagtcg gtgcacggaa cggtgtcgtg tgggaccaca tgacgaggcc
     6061 ggtacgtgac gacgatcgca cgatctttgg aatgatggac gcctccaccc tgtacgccga
     6121 ccttcctgag gatttgaggc gttactcggc ggagacgttc gacgacaagt acaagaagct
     6181 cgactgggag tcagtaagtc gctccatcac cgcccacatc gccaaggacg gctactggta
     6241 cattcaccca caggaactca gaactctcac agtccgcgaa gccgcccgag tccagacctt
     6301 ccccgatcgc ttccgcttcg cgggcactcg cagtgacgca tttcgccaaa tcggcaacgc
     6361 cgtccctccg ctcctaggac gcgccgcggc agctgcgctc cgcccggtac cgacgcacga
     6421 acgttccgaa gagcggctgg gggaagtttc gcgctggatt gaggcaaggc aggcgcttac
     6481 cagttgggca aagcaacagc agcgcggccc tagttggcat gcgttgcccg gtcaaggtgt
     6541 cacgccggcc gtggccgccg tcgcagcgct tctgatgagt cggtccaacg ctccaagagg
     6601 caccgaccga gcgcttgcca cgatccgagg ccgtacacgg ctgacgaagg cggagctcga
     6661 ccagatgcaa cacgaactcc cgacgcaggc agggcgtcag gtgctggagc gattccggcc
     6721 gttgctgccc aagcgcaagc tatggacgga tccagaagcg ctgatcgagc acctggccat
     6781 gaaggcagcg gaagagcgaa ccttccgact cctggtaggc gaggacgtac tccttgcgaa
     6841 ccaggcgact ctcagggttg cggcacgggt agcgggcagt ggctcggaca ggacgaacag
     6901 gctgagcgac ggccgtgtcg atctggcaag actggtcgga gctggcccgg acgcgccgct
     6961 gcgcgcggcg gcgctccgtc tgctcggtag tacggtatgc aaggcaccca gcacggtatg
     7021 cggcgactgc ccactcaggc agcagtgcgt cggcagctca agtgagcgcg ctgtgcagac
     7081 cctgttctag ccgccaccgc tctggttcgg cgcgcaggtg gtccgcgacg gccagccggc
     7141 tcccgtccac ccggaccacc agggtccaag tgggtctggt gtccgacatc cgggacgatg
     7201 cctacgattc aatcgccagc cacatggtcc tgttcgatgc gctcgaagat gtctgcgtcg
     7261 gtctcctgct gccaggcggg caactcgtcc cagttggcaa cgtaggaagg cttggggtca
     7321 gaaaagtgcc ggtggatctg gccggtccag caggcggcga tgaactggcc cttctgggta
     7381 cgagtcagct tggcggcttg accagcggtg atggtgagaa aagccaggac ctgcgagtag
     7441 accgcggcgg cggaggcgcg ttcccagtcg ggggtgtcct cccaggcggc gacgtagccg
     7501 ggtttcggct cgcccgggta gtgcttgcgg accccggcga tccacgcctc ccggaagatc
     7561 cttccacctt cggtgttgct cgcgggcacg cgcgttctcc ttggatcctg acggtgacga
     7621 ttacggtcgg ctcgatggcg tcaggctggt gatcaggcga cgccagcacg gacggcgaac
     7681 tcgcgcaagc ccggcagcga cggcccggaa gagcgcagtt gccgggtcaa gcggtgcgcc
     7741 cacgggcgca gcctgatttc ctgcggggcg gcgcgttcgg cggcgagcag agcgtggaat
     7801 gcctgttctc gcttgcccca ggcgccgaag gtcagggcaa cgtcctccca atagcgcacc
     7861 agccgctcgg tgacggtgat cgtgccggga cggatggcgc gggccgcctc gatggcggtg
     7921 ccgtagtcgc cgagcttgcg gtgcacactg atctcgtaca accccaggta gcgggcgtcc
     7981 accgccgacg gggtgagtgc ggtgggcaac gccgtccggg tggtacgggc cgcggtggtc
     8041 gcctctgcgt gcaactccaa ggcggtgtca cggcggccgg cgatggcggc ggtgtacgcg
     8101 ccggtctcca gcagcatcgc gtaggccgcg ccgtacccag agctggccag gccggcatcg
     8161 gaatgcagtt tgcctgcggt gtccacgacc agatgctggg ccttgtcagg ctgctcgaac
     8221 cggcgcagca cgaccgcacc catctgagcg gcttcggcct ccaccagcag gttcccggac
     8281 gcgcgggcag ccgagagtgc ctggtcagac agaccagtgg ccagtccgtc ctcgcccagc
     8341 cgcagcgcca gccaggtggc gtgccggtag gcggtggcca tcagcgcgtc cacttcgcca
     8401 cgttgttcgg cgtccacggc ggcgcgcgta gcctgcgcgt ggcggattac ctgcggcagg
     8461 ccagcggcca actgggagta ccggcaggcc aggtagtcgg cttgtatgcg gtcgaccagg
     8521 cgacgcagct cgtcgacggt cacgggtccg gttgtcgtgg actgggcgtg ggcgtcgggc
     8581 aggccgagca acgcggcccc ggcgacaccg agcaccccgg ccagcagttc tcgacgcagc
     8641 acgtcatcac cgccattcag agggtctgct ggccctacgg tagcgagtcc cagtcgctga
     8701 gggtggatgc cgtagcggtc ggccagccgc cgcaacgtgt cggtgtccac cggacggccg
     8761 cgttcgatgc gggacagcgc cgagccggag tagcccagca gcttgccagc ttgcgccaag
     8821 gtgaggcggc gcctctggcg ctcggcgcgc aggacgtccc caggggatgg atccgacatc
     8881 tccgtgatcc tcacgtgtcc cgcctgtact ccaccagacc caattgggtc aagaggctgc
     8941 ccggaatcgg cacaccgtgc gcacgcagcg cacacaagct cccgattcga cctgaacggt
     9001 cgttagctgg ctccagcgga catggcgtcc agcggaccag gtggaacgga gcatcccgca
     9061 tgagcctccg ggcgaagcga gcagcgcggt tgccgctggt gctggcgcac gacgaccagg
     9121 tcgtcggccg tctccctgca accggacgcc ggacgtgtct tcgaacgtct gccgtgctgg
     9181 ccgtgcggac accggtcagc acggcaggac cccaccgatc acgactgcga ggacgtcatg
     9241 tgggtcgcca ccgcgctcac gctgctgggc ctgttgctgc tggcgctggc cgccggggcc
     9301 agcttgatct acgggttgcg tgcctggcgg aaccaccggc ggctgacccg gcgccgcacc
     9361 gcggatgttc aaacgcatgt ggcggagctg cgctgccgca ccggctctgg gaagcaggac
     9421 cacgactcgc tgccgtcacc ctgccagcct gaagaaggag gtgatcagcg cgagcgatct
     9481 ccacgcggcg accggaccga cgacgaagtc caaggcggcc gacatcgagc ggtgaggcca
     9541 ccgttcgaag gtcgtgtccg tatcgccggt catgtcctgc acaacgccga cacccgacgt
     9601 ctcccccgca ttccaccttc cgccggcgag ggctgatcta cccgaaacct cgacatcgct
     9661 catggcgaca ccaatcacca ccaggttgct gcaccaccgt gccgccttcc cgaatggcct
     9721 ctgctgccaa ccgcaagatc acgcttgcga tgcgcgtgta acgaactaag gagaccaacg
     9781 tgacaactgc tcttcaggac gccccggtgg gcgccttcga cctggacgtg cggatcgaga
     9841 ccgaacaggt gggggtcgaa gacgcggcgt gcgcgaccga cgacggctgc gggcacacct
     9901 gcgagctttc cgcctgccac tcacagcggt gatctgacga cgacgagcga cgtggggccg
     9961 ggtgcgaagc ctggccccat gccgggagga ggacgtagac atgtgcgctg acaagggttt
    10021 cgtccactac caacaccacg ggaccgggtt gctccgggca acggctgaag tcatcgacat
    10081 ccgccgttgg ccggatcctg acgacgagca ggactgtcgt tcgtggttgg tcgaagcctg
    10141 gccccttccc ggaatcgccc cggcgatccg gcacgccagc cccgtccttg ccacccgcgt
    10201 ggagacgatc ctgtcgggcg acgcggtggc agcacgggac gtccgacgcg ccaccctgtc
    10261 cgtcgtccgg tacgtgttgc gcgctcgtgg ccgaccgacc ccgttcggca ccttcgccgg
    10321 cgtgagcacg ctggccgtgg gaacctcgac agacgctcgc tggggtacgg gtcatcgtcc
    10381 tgtcgtgcgt gcggagacgc gctggctcca ccgggtcgtg caacgcctgg aggactgtgc
    10441 tgagctggtg gcgcggctgg atgtcaccct caacgacgcg gcggaactgc gcgccggacg
    10501 gtgggaactg cccggcccgc gcaaggtcag cgtccgagcg acatccgcgg tggcgatggt
    10561 tcgggacgag gccgccgtgc caatcggttt cggtgtcctc tcggacaagc tggcccacgc
    10621 cttcccggag gccggggacg cctcggcgat gctgatgtcc ctcctgcgaa acggtctcct
    10681 gttgacctcg ctgcgcgcca cgggcacggt caccaacccg ctggcgttcc tggtcgaacg
    10741 tctgcgggac gcgggtgccg actcgttgcc catcgccccc ttggcggagg aactgaaccg
    10801 gattcaccgc gcgatcaccg agcacaacca cactccaagc gagcaggccc gcgttgacct
    10861 ggcttcgcgg atgcgtgagg tcgcggactc ggtgcgcgtg ccgctatcgg tcgatctccg
    10921 gctcgacgct cacgtgcagc tcccgcaaca ggtggtccgg gagatgcagc gcgccgccgg
    10981 cgtgctggca cggctgaccc gtgaaaccac cggcagccgc gagtggcgag agtggttcgc
    11041 cgcgttctgc gagcgctacg gcaccggcac gctcgtacca ctgcggatgg tcatggatcg
    11101 agacggcgga atcggcctgc cccgcggcta tccgggcagc ccgcggctgg cccaccggca
    11161 tgtggtctcg gcacgtgacg agctgctgct ggctttggct gccgaggcga ccgccctcgg
    11221 acagcgagag gtcgagctgg acgaagcgct ggcggagaag ctggctgccg ccagcggtga
    11281 gcgggggaca cctccgccgc acgtcgacct cggtgcgcgc atccacgccg ccaatgccgc
    11341 cgctctggac cgtggcgagt tcacgctgac ggtgtcgccc ggacgggccg ccgggacgct
    11401 cacctcacgg ttcaccactc tggtgccgga ggcggggctg gcagcgatct tcgccgcgtt
    11461 gccgaccacg accgccggcg cggcgccggt gcaactgtcg ttctccccga tctacccggc
    11521 tgcggagaac gtgtgccggg tgcccgcgta cctgccggac gtcgtgtcga tcggcgagca
    11581 cgtccctgat ggggcgatcc gcgttgacga cctcgcggtc accgcaacgc accgacgcct
    11641 gcacttggtg gacctttctc gtcgccgcgt cgtcgaaccg caggtgctgc acgccctggc
    11701 acccaagcag caaccggcga tggcacggct ggtcggcgag ctgacccgcg cactggacgt
    11761 tggctggatc gggttcgact ggggcgcggc cgacgcgctg cccttccggc cgcgagtgcg
    11821 ctacgggcgg gccatcctgt cggcggcccg gtggcggctt gtgcagaccg atctgccgat
    11881 gaatccggct gagtgggatc aagccctgca ctcctggcgg acgacgtggc gctgcccggc
    11941 acgggtcgag ctgcgcgact tcgaccagtt gctgccgctg gatttcgacg tgtccgcaca
    12001 tcgaaagatc ctctaccggc acctgcgcaa gcactccgag gccgtgctgc tggaagcagc
    12061 cgacccggat gcggacgggt ggctttccgg tcatccgcac accgtggtgc tgccgctgac
    12121 ctccttgcgg gtgcctgagc ccgctccggc cgtcgaggtg ctgccgatcc tgacccgcga
    12181 acacggccac ctgcccggct cgtcctggct gtacgccaag ctctacctct ccgcgagccg
    12241 gatggatcac ctgctcgtcc acgagttgcc cgcgctgctg gccgcgctcg gcgaccgcgc
    12301 gtgctggttc gtccgctacc cgcaggcccg ggaaggggag gaacccgatc aactgcggct
    12361 gcgggtccgc gcgcacggcg acaagccagg tgacaccgac cggatactga tcgcggtcac
    12421 ctcatggggt gaccgacttc gcgccgaagg gctgatcgga cgactggcgt tcgacaccta
    12481 cttccccgag gtcggccgct acatcgccat aaaagaggcg gaggacgtct tcaccgcaga
    12541 ctcccacctg gtgctcgccc aactcgctca cctgactgcc gacgccgtcg cccccgccgt
    12601 gctcaccggg ttgtcaatgt tcgacgtggc cgctgcgttc ctcggcggcc ctgccgccgc
    12661 cgcggactgg ttgagcaccc aggccactcc cgctgctccc gaccgcgctg aggtcaacga
    12721 ggtcacgcgg ttggtccgcg acggatggca gcccggcatt cccggatggt ccgccgtctc
    12781 cgaggctcac cgacaacgcg ccgacgcact cgcccggtac cgccgagcac tgcccgacgg
    12841 cgtggacatc gaccgcgtgc tgcactcact gctgcacatg caccacaacc gcgcgctggg
    12901 cgtgaaccgt gaccgcgagg cgatctgtct gcggttggcg cggcaggccg ccgcagcctg
    12961 gcgaaccacc caagacatcg catgacagta caaagacgcg gacaggtcca cgacgtcaag
    13021 agcgcccgat gggcgcagtc actggccgac ggtgcggcgg gcacggcact gctgcacttg
    13081 gagctgggcg aggacgctga ggagtggctg acggcgatgg tcgccgaacc ggtgctggcg
    13141 cacccgcacc aggccacgct gttcgacggc gcaccggctg tggcgttcac cctcgccgca
    13201 accacccacc accgtgcgct ggccgcagtg aacgagcatg tcgaggcggt catccgcgcc
    13261 cgcttggacg ccgctcaccg ccggatcgac tccggcgagc tgcccgccaa gcgggagttc
    13321 gacctcgtct ccgggctgac cggcctcggc gcgtacctcc tgcgtcgcca cggcagcacg
    13381 gagcggcatg gtgcgcagtt ggcggacgtg ctcgtctacc tggtgcgtct gaccgaacca
    13441 cgccccgatg gcctgccggg ctggtgggcc accagcgggc caaccggtcc cggccccgac
    13501 tgggcgggcg gacacggcaa cctcggcgtc gcgcacggca tcgccggacc gttgacgctc
    13561 ctggcgctgg cgatgcggcg cggggttgtc gtacccggtc acgccgaggc ggtggaccgc
    13621 atctgccgct ggctggacca ctggcgtcgc gggagcgggc accggttgtg gtggcccgga
    13681 gcgatcactc gaaccgaaca cctcaccggt gccctacgat cggctggccc gcaccgcccg
    13741 tcttggtgtt acggcacccc cggcatcacc cgcgcacaac aactggccgc actcgccctc
    13801 ggcgacatcc gccggcagcg cttcgcccag cgggcactgg cctggtgcct gactgacgaa
    13861 gcccaattag cccagctcag cgatgtgtcg ctgtgccacg ggtgggccgg ggtgctgcac
    13921 actgcctggc gggtgggaga gcacgatgaa caggtgcgcg cccacgttcc gcggctcgcc
    13981 gagcggctga cagagcacct gctccaccac ccgccgcctc cgcacgggct gctgaacggg
    14041 gaagccggtg tccggctggc acagcgtgcc gcgaccaccg acacgacgcc catcacgcga
    14101 tgggacgcct gcctgctgct ggacggttga ccatgaccgc tgaacgacga aaggaaccga
    14161 tggactccga caccgccacc gacccgacgg ccgagaccgc cgcctcaccc gaggcgttgc
    14221 gcgctgagat ggtcgagaag gtccgcaagg ccgggtatgc ccagcgcgag gaggtggagc
    14281 gggtcctgcg ggacacgccc cgccacgagt tcgtgcccga ggccggcctg aagtccgcct
    14341 acaacccgtg gcaggcggtg atcacccacc gcttcgagga cggccgctcg ctgtcctgcg
    14401 catcggcgcc gttcgtggtc gccatgatgc tcgaccagct cgacgtccag ccgggcaatc
    14461 gagtcctgga gatcggcgcc ggaaccggct acaacgcaag cctgctcgcc cggttgaccg
    14521 gccgcgccga cctggtgacc accatcgata tcgacccgga tgtcaccgcg caagcctcac
    14581 gcaacctgac caccgcaggt cacgccgacg tccacgtgat caccggtgat ggcgggctcg
    14641 gctacgccga ccacgcgcct tatgatcgcc tcatcgccac cgtctcgcct tgggacatcc
    14701 ccgccgcctg gtggcagcag ctcgcccccg gcgcacggct ggtcgcgccg ctgcgctggc
    14761 gcggccaggc acgcagcgtc ggcttcacct acaccgacgg tcggctggtc tccgactcga
    14821 tctacctgtg cggcttcgtg tacctggtca acgccgacga gggcgaactc agcggcccga
    14881 tcaccgccga cgagacggtc aagctccact gggaccggga ccaagccatt gacctggacg
    14941 cactgcgcgg agtgctcgac cagccgcgca ccaccgcctg gtcgggcgtc accatcgccg
    15001 gcgacgagtc gcacgacggg atctggctcc gccttactgt taccgaccag cgcgtctgcc
    15061 ggatcgacgc ccactccgac gtcgcgcccg aggtgtgcga cccgatccag gcgttccggt
    15121 ccccggcgct ggtcgacggc gactccctgg cctacctcac gtcccgccgc cagaccaacg
    15181 gcgacgaggt gcggtgggag ctgggcgcga tcggccacgg cccggccgcc gccgagttga
    15241 ccgagcacct gtgcgacgag atccgagcct ggacgcccga gcgcgatcga cggaagccca
    15301 ccctgatcgt ctaccccgtc gacatgccgg acagcgagct ggctggccct gccatcgaca
    15361 aaacccacag caggttcgtg ctcacctacg acgacgtgtc cggctgacct caagaccgcg
    15421 ctgtgcggac tgaggggcgg aggtccatac cccagccagg tctgcacagc ccgcgttgag
    15481 gctggtccgt tgactggaga cgtcggttcg ggtcggcaca ggactccaca ccctgtgccg
    15541 acccgctcga cgtccgacaa aggttcaggg ctgggcagcg cggagcaccg gttctggtcc
    15601 ggcgctccgc gcggttcagc gtgtgcgtct gatagtcggg tctggttgcg ggtgctgtgg
    15661 tcgtcgcgcc aagggcgggg atagtgatga tggtttgtgc accggctctg gttgaaatga
    15721 cagcggctcc gggcggccgg ttggtgggtg tcgtttggcc aggtaggcgc tgtagttgtt
    15781 catcctggcc gctgcgcggg tggcggcggt ggcttgtgct tgctggcggc tcagctgtcg
    15841 ccacgcggcg atctggacca gcagtgcgat aagcgcgagg acgagggccg cggcgagcag
    15901 gccggtactg ttgcgtttgg agaggatgcc cgccctgaac aggtcgcgtg cggtggtgcg
    15961 tagcgctgcc gcgacctcgg tctgccagac aggctggccc ctgcgcggtg ctgtggcggc
    16021 ccgctcgtag acgacgacca cctcggccag ggcacccggt tcagggccac cgagtgccct
    16081 ggcgaccgcg acgagcatat ccgccgtggc gtgggcgacg tcgtcaccgc cgctgccgtc
    16141 ggagacatcg cccgcgatga cgcggccggt gaggtggcgc cgggcattgt cgacggcctg
    16201 cgtcgctctg gtgagcaact cctcgggagc gcggcgcact tccgcctgct cctgggctgg
    16261 ttgtcgtgtg ctggtccacc tggcggtcag cttcggagcg gacaggtcat gggcgagact
    16321 gctgccgctg aaccagatcc ggccgtcggc agatgctttc tcccactccg cgcgcaacgc
    16381 cacgcggtaa gcggtcagtt gcctgtccga gccccagcgt ggctgcaccg ccacctgaag
    16441 gtcacgctcc agcagcgcga tgaactcccg cgccgaggat gcctcgacgg ctgcggtacg
    16501 gaccttcgtg cgcagcaggt cccggttggt gtccgctcgc cggtagcggg tggccttctc
    16561 gacttcggca cgtgtcgacc gtatcggcgc cgtctggttc gccggcgagg tccgggtcag
    16621 gtcgaggcgc tgctccacct ccaggcacca ctgccgccag cgcggccagt tgcggtaggt
    16681 gtcggcgatg gtgccgtcac cgcggacgag gttgatggcg acgtggacgt ggtcgttgcc
    16741 gtccttgctc gggccgtggt gcaccgcgac ccaccggcac ccggccctgc cgtcgtcggt
    16801 cgggccgaag cccatccggt cgacggcctc ctccaccagc tcgcgccaac gggcatcacc
    16861 gagcgcgccg tcctggctgg ggatggacag caccaggtgg tagacgtgac cgccttccag
    16921 gtccacctcg tgcccggtcc tcggcgcgtc gatttcccga gcgaggcggg ccagccagcc
    16981 gcggtggtgc tcggcgaacg cgccgccctc cagccactcc ggatcccagg ccgcgaccag
    17041 gtgcgggtcg gtgtgctcgt tgctcttgcc gggaccgaac aggtagcgca gcagaccgta
    17101 ggtgtccttg ccgtacttgc ccttcgccgg agccttggcg atcacagctc gcgctcacgt
    17161 gaggagtcgg ccgggtcgat cgccgcgagc acggcccggt gctgctccag ggtcgcggtg
    17221 aagtaggcca gcgcggcggg tagctccggt ggtagatcgc cggtgctgtt ggcgacggtg
    17281 gccatctggt tgaggttggt gccgatgcga atgagccggg tctcgacggt gtcgagtcgt
    17341 tcagcccacc agcgctgctc gcgcaggctc cagccggtgg tcgagtcgcg cagcgcggac
    17401 tccaccaggt agcgcgggat cgacaggccc gcgaccgccg cacgtgcgac gagagctgcg
    17461 taggtcgtga ccgtggtgcg gacgtggatg ctgacgggcg agccgcccgt cacgcgacgc
    17521 tgccgccgcg tcttccgttg cgtcatcagt tcccccgatg agtagccggg cgtgccccct
    17581 gcacgcccgg gacgtcaacc gcagcgctcg gctgcggcat cgggatccgg taaccggatc
    17641 cctaacttgc tgaccgctgg tgggggtggc tccccaaacc gcccccacca gcggtcaggg
    17701 cttccgcggc gacgaagaaa cgaagcaatt cgtcgctcaa ccggccgcta ggactcggca
    17761 cgccggtacc gcatcgatgg ccgtccgcgc tccccggagt gccggaattc ggtgtactcg
    17821 ccggtggcca tcacctcgtg gagcagctcg tcgagcacct gtttggtgag gttgcgcccg
    17881 aacaacgcgg acacttcgcc gcgcccaagt ccggcctcgc ccacaccgtc cagagcccgg
    17941 cgcaaggtgt cgactctcgg gttgcgcagc gtccggtcga ggacgaactt ggccgttccg
    18001 atcgagtagc gcaccagcgc ggcagccgcc ttgaggtcct tcacgtcgac ctggtcgcgg
    18061 tcgtccagga ccgcgtacag ggcggcgatg cggcggcagt acggcaatgc tcgacgggcg
    18121 aactcggtcc aggcgccctc ctcgtcgtca gcacagccca gctcgtcgta cagctcctcg
    18181 ttccacaacc ggcgggcttc ctcgtccagg ccgacttccc cgtgacgcgc tgctcgctcg
    18241 actgcttcgc gcagccgggc acccagctcc gacaggacct cgggtgcaat cccctccggc
    18301 aacgggagcc gcttggagcg ctcgacgtag acggggagga agcggttgaa ggtgccgccg
    18361 gccatctcag tctgggccag cctgaggcgg aactcacggg gcgtgacgtg gccgatgatg
    18421 accacgtgcg aggacgaggc acgcagcgcg aggcggttca tcacggccag agccttgccc
    18481 gaccagcctt cgcgcagcac cgctccgacg gtgttgccct ctcgcttggc gcgggccatg
    18541 acggagccga attcggcttc gaggatcctc agccgcttgt cctcggtgcc gcccgggtcg
    18601 ttctcgtcgc gcgggtcgcg gatgcgttcg atcagccctt caccggagga caggccactc
    18661 acgaataggt ggccgacctc gggcacggcg gcccaggtga gccggtccgc ggtctccgtg
    18721 gcatcaccct tgcgtcccgc accggtgcgg ccgaacagca gcggccagac gatcagtgga
    18781 tgccgggtgt tgccgatctg gacgtgtgga ccggtgccta tgacggcact gacgttggcc
    18841 atcagcgaca ccaacacgcc gatcgggtcc gcctcggtcg tcgggtcggc ggccatcacc
    18901 agctcaccga gcaccccgcg gaagaccgtc gggtccactg cgggaggagc gggtggcaat
    18961 tcgttcgttt tattcgtctc ttcgtaggac tccccagagt gcgtcacgta cgaccgtcct
    19021 cgtggtcgat cgatggccgg ttcgcgcgtt cagcagcggg tgcgctcccg ttgaggatcg
    19081 ccgcgatccg agcacgctgg ctggcggtga acggcggcgc agcgcgaacg atgcgctcga
    19141 cgtacgcttc caagcccgcc tcggtggctg cctgggattc cgttagcgca cgccgtgtcc
    19201 ggcactgcct gccgcccggg ttggtgagct tgcggcgatc tgtcatcgcg cctcaccgcc
    19261 ctcacgccgc gcagtggcgt aggcgtcgag gtcggcgacg gcgatccgca cagcccgtcc
    19321 gatccggacg tgcgcgagcg cgccggacct gatggcgcgg cgaatcgtca cctcggacac
    19381 ggacaggcgc cctgccgcgt cccccacgga caggtaggcg ggttctatgt tcttgtctgc
    19441 cacggtgtgg cccttccgat gcgggaaggc cacgacgggc tacgtggtca aagcgctccc
    19501 ccaagcgtgc acagcccgac gtggccctcg ctgcacgaca gcggcgaggg accaacggcg
    19561 gcccggcgcg cgagctacac ggggctcagc gagaacaagg cggcctggtg gatgctgcgt
    19621 tcgaggcggc ggtgcgttcg aggccggcca cgtcagaagg tgcggcacga gccgcgggcc
    19681 gaagatcaag agcaggaggg cgcggagtgc tgtcgggtac ttccgggcgc ccaacgcagc
    19741 ccagaagagt agcagtctga tcagctggat gaccgcttcg gcgtcactga tcaccttctc
    19801 ctgctgggct cgtgaggagc ccgggtagta cgagacggtg atgccgagat cctgtggcgt
    19861 ggccgtggtc aacgccttgc cggtcaatac gaacaggtct tcctgcaccg tgtacggcag
    19921 atcgtccgct cgtcgcagca acctcagtcg cttcgcatgt cccgccgtga tccgcgcccg
    19981 gatccggtcg tcgcgctcga cgaatgcctc gaacccggcc gccagtccct gcggccatcc
    20041 ctcgtcggga ggctcggcct gcgtgaggcg aagcgcgcga agactattga ccgcgcgcct
    20101 gatctcaccg accgaatagg aatccggtac agcggacgac ggcacggcca accgttgcgg
    20161 cggtcgttcc tctacgatcc tggtgttgtc accagccccc atgagaccac gttagaccac
    20221 gttagaccac acagggcaga cagtcgaacg actcacagtc ggtactgaga caactacatt
    20281 gcgatgtcac aaaaacgtca ggtaagtttt aacaaaaaag cggtcttcct cgcggttaga
    20341 aatcaaacga aggatcaata aaaccttcgc aagaattgac acacctataa caacgtaaaa
    20401 ttccctcgct tgaatcgaga tcaagcactg cccctagcgc ctctacatcc agcgagatgc
    20461 gcgtgggtcg cgctagcggg tcgcgcgggc gggacaccat gcttacttcc tcgaggtcaa
    20521 tatcgccatg gatcgccacc ggattgacct cgacagactg tcccggaaca tgcgaacaat
    20581 cagtccagcc gcaacaatta cacctcccct ggtcgtccct agcggcgatc atctcatatt
    20641 tctgtccgat caaatgagga cagtcgtcaa tatcctcgaa gcagattgaa caaaggcgtc
    20701 gacttgtgta gccaggcgag aatccccagc ggtgatgcat cagagttgcg gggcattcat
    20761 cccagtagac tccgtcgtac atccgaatcc agcagccgaa gataccaccg acaaattcac
    20821 cgactgcgtg cgcatgctga tgagcgatat cagcaagagg atgatcttcg agaaaattgt
    20881 acgcggaaac agccgcatcg agggcgttcc gcgcggctga ctcagcagct cgatactgcg
    20941 cctggtaacc agagttgccg atgccgtagg cagtctcacg ccggtgcgtg agcaaatctt
    21001 cactagtacg ccacacctgt tgccggcgac gcgcatcttt tattccatca tcgaaagcct
    21061 gcgtcctcca catgccgtgc gatcgtgaga agacccgcag atcccaagcc aacgacagtc
    21121 ccgcaatgcg cagactaaga ccatactgtc ggaatgattt cctaaggtag gttattcctt
    21181 cgtgctcgag gtaggccgct cggcgcgacc cagcggcagg agcgataggc acacctgtcc
    21241 gggccaccaa cccgccaacc aacagccctc cgggcccata cttactcgct ttggccatct
    21301 ggctcaccat cgaacgactc gacctcggaa tccacgagtg acttaatcag atcaatcact
    21361 ccactcaccg ggccactaca ctccaaccct tcaattacgc gacgctgggg cgaggattca
    21421 aaacgtgcta ctttgaaggt aacaacttca tcgatctcct ggccatcaag tacaggacgg
    21481 ccgagcgctg ccgcaacccg gaactgcact atgcgataca tatacctgat cacatcggtc
    21541 gtaaaattgc caactacgcc gagcgtgaca gcggcaatga cttctcccgc cccaaactcg
    21601 ctaacgtaag cacgccgatc acgcggccaa gcgaactcaa gcgatgcacc ttcggcccgg
    21661 atggttttaa ccaagcctgc attatcatcg cgatatagag ccctaccttc ctttccgatc
    21721 ttatctggaa gtagaagcag tgttccaggg tccactccag caagagtcac cggatcgacc
    21781 atctccatcc gaggagacca tgaactagtg gacagcttcc cagcgtcgtc cattacttgc
    21841 acctctccac tatgtgatca catcagactt tacctcacgc caagcctatg gccatcatga
    21901 ccgcagccca tgtcaaccga tcgtgaagat ttacagcctc atgcatagat catgcaacgg
    21961 atgtcaaccc ggttaaagcg accccacatc ataacccgat ggacgcgaga tgtgaaacgt
    22021 ggaaggactt gccgataggc ttcagtgcca gtattcgtat ctcgacagcg gacacattgc
    22081 atgcggcgcc atgccaacgt tgcacgggga agtcaacgtc ggctgctcat cgtcaatgcc
    22141 gctgtcatct catcggccat cgcgctctct ctgtcactca tgaaccgcac gtcaacggac
    22201 tccggtctaa aacccgcacc gcctcgggca ggaaggatcg tcaccacgac acccatcgcc
    22261 tccagcaacg cccgcttctg ggtcacctgc aggtcgcgcc aacgttccct ggccttggga
    22321 ccgatgatgt ccccgaggat gtgcggtggg atcccttgaa ccgcgcgcat ggagtcctgc
    22381 tcggccttct ccaactccgg ccgcagcgtc gtggtgatcc tccgcatctg ctcgcggtcg
    22441 ataacgccgt ccgcgtagtc gtcggccgca ccgttcaggc gagcgcggag tgtctctacg
    22501 cgctcacgtg ctgcccgcgc cttgtcgtcg tctcgggtca acagatcacg ggcatctggc
    22561 tcttgcagcc ggcgcacgac tacgcgctcg acgaggtcgt ccacccagct ctgacgccga
    22621 ccgacgcacg atgacgggct gtcacacacg tacagcggga ccttgcccaa ctccttgtgt
    22681 cgcgggttga tccacttctg ggcaacccga aggcgggtgc cacacccagg cttgccgcac
    22741 cgaccgatac cgaaggtcag gagatgctgc cgcgcaccac cgcgggtctg cactcgggat
    22801 gggtcgttca atagcgccgt gacctggtcg tgtcggtcac tttcgatgat cggcggccag
    22861 gcggccgggc cgaagtcctg gcgcccgcgg gctcgcctcg cgatgttcgc gagacgcagc
    22921 gccagcttgc gcactgagct ggtgcgccac gtcttgccgc cgccctgtgg cgtgggaacg
    22981 cctctcgcgt tgaggtctga ggtgatcgca ttgagcgact cccgagccaa caggcggtcc
    23041 acgatctcgc ggactatggc cgcttcctct ggctcgatct cgtcgtacca gtcgatcacc
    23101 tcgccgctgc tattgcggac cttcaccctc cgccagccgt aggcgaccgc accgttggcc
    23161 ttgccctcct ctgcgcgctg ccgggccgca gcctccaccc gctcggcctt gacctcggac
    23221 tccatcgtgt cgaactcgcc cagcagtccg gccagcgcgc ggccgtaggc ggaggtcaag
    23281 tcgatgtcgg agcccttcac caggaccacc gagacgcctg ccttggacag cttctcgatc
    23341 gcctcggcac gctctcgacg gttgcgccac aacctggaca tctggaatgc cacgatccgc
    23401 gtgatcttgc ccgcgactgc cgcttcgatc agcctgtcgt actcgggccg cgggccgccc
    23461 ctgagcgcgg ataggtcgtt gtcgacgaac gtgtcgtaga tcgtccagcc acgctgtccg
    23521 cagagggcca caccatcggt gacctgccgc ttgacgccct tctccagccc cagcgggtcc
    23581 tcgctgatac gggcgtagac ccccaccgcc tcgtccatgc ggtaaggcta gcgcgtgttc
    23641 accgctaatg acacttgcta gcctctgaag cacctggtta caagattgct acaggcactc
    23701 gtcgcgctgg tcaggacatg aagacccgac tttcgacgta ctgccggggc gacaagtgct
    23761 ccaccgcagc catggatacg actccacctc gatgcgagta gtcgaactta tggggtgacg
    23821 ttcgcgcggt tggtgatcgc gtcacgctga gatcggtcaa ccttcgggcg ggggcctaac
    23881 gcgagtgacc ggcccaattg gtttaatgac gccatgacgc aggccatcac gaacggtgcc
    23941 actatccgct tgttcctcgt cgacggcaca ccgcagggga tacgagtcgt caaccgcagt
    24001 cagtggaccg gcgtgtgcct cgctttctcg agggctgact acgcgagcgc acgcctccgc
    24061 gaagagttcc ggcgaaccgg cgtctatcta ctgactggtc ccgatcccga tgccacggga
    24121 cccgacgttc
//
