LOCUS       NZ_CP064192            22910 bp    DNA     circular CON 30-JAN-2024
DEFINITION  Saccharothrix sp. 6-C chromosome, complete genome.
ACCESSION   NZ_CP064192
VERSION     NZ_CP064192.1
KEYWORDS    RefSeq.
SOURCE      Saccharothrix sp. 6-C
  ORGANISM  Saccharothrix sp. 6-C
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharothrix.
REFERENCE   1  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Saccharothrix texasensis strain 6-C
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2020) College of Life Sciences, Chongqing
            University, University Town Road, Chongqing, Chongqing 401331, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 10:20:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,916
            Genes (coding)                    :: 7,819
            CDSs (with protein)               :: 7,819
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 41 of 97
            Pseudo Genes (incomplete)         :: 78 of 97
            Pseudo Genes (internal stop)      :: 6 of 97
            Pseudo Genes (multiple problems)  :: 27 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:34:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6231329
            Orig. end                         :: 6254239
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP064192.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22910
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="33"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22910
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22910
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12910](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12910
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    25..39
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.49"
                     /tool="antismash"
     misc_feature    complement(1051..1066)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            complement(1063..2136)
                     /locus_tag="IOD16_RS26030"
                     /old_locus_tag="IOD16_25895"
     CDS             complement(1063..2136)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103766.1"
                     /locus_tag="IOD16_RS26030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25895"
                     /product="alkene reductase"
                     /protein_id="WP_201436494.1"
                     /transl_table=11
                     /translation="MSTAFEPLDLAGTKLANRIVMSPMTRSRAYDTVPTPVMAEYYAQR
                     ASAGLIITEGIQPSAVGQGYPHTPGLHTDEQVAGWRVVTDAVHEAGGRIFAQLMHSGRI
                     GHPSLLPGDLHPVGASPVRAAGQLYTGEGMTELVTPVELGPADVEATIADFAAAARRAV
                     DAGFDGIELHGANGYLLHQFLADNTNLRDDEWGGSVENRIRFTVEVVRATAEAIGGARV
                     GLRISPFNRYNDIAEETTAELYPALVDAIEPFGLAYLHIGEAGDRALTLELRERFSGVL
                     ILNPHTPDGVTGPDHLSLLDEGVADAVSFGALFLANPDLPARLANGGPFNTPDQSTFFG
                     GAEQGYTDYPALTSVNA"
     CDS             complement(2174..2263)
                     /gene="allorf_6233503_6233592"
                     /locus_tag="allorf_6233503_6233592"
                     /protein_id="allorf_6233503_6233592"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSGRGHGSSLAARDRERCHSETSECTPCC"
     CDS_motif       complement(2228..2263)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSGRGHGSSLAA"
                     /locus_tag="allorf_6233503_6233592_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(2174..2227)
                     /prepeptide="core"
                     /locus_tag="allorf_6233503_6233592_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.80"
                     /molecular_weight="1940.1"
                     /monoisotopic_mass="1938.8"
                     /core_sequence="RDRERCHSETSECTPCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSGRGHGSSLAA"
                     /leader_location="[2227:2263](-)"
     misc_feature    complement(2197..2213)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.28"
                     /tool="antismash"
     misc_feature    2206..2221
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            2282..2752
                     /locus_tag="IOD16_RS26035"
                     /old_locus_tag="IOD16_25900"
     CDS             2282..2752
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020628630.1"
                     /locus_tag="IOD16_RS26035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25900"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_236594391.1"
                     /transl_table=11
                     /translation="MLQIDEDGRVSHAIFRVARLHRMLAGQLLRQAGLHPGQEMVMMRL
                     WDRGPQRQSDLCGELGADSPTMTRTVQRLERAGFVRRSPDPTDGRAVLVEPTAASQALR
                     HQVERMWRELEEATLGDMDEDQQAETLRVLGLLECNLAVRANKPVGRPSGQA"
     gene            complement(2736..4256)
                     /locus_tag="IOD16_RS26040"
                     /old_locus_tag="IOD16_25905"
     CDS             complement(2736..4256)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1257: Alpha-glucosidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020640279.1"
                     /locus_tag="IOD16_RS26040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25905"
                     /product="glycoside hydrolase family 13 protein"
                     /protein_id="WP_123746486.1"
                     /sec_met_domain="Alpha-amylase (E-value: 4e-72, bitscore:
                     242.4, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNWWRGAAIYQVYPRSFADGNGDGIGDLAGLRQKLPYLAELGVDA
                     IWLSPWYPSPLADGGYDVADYRDIEPVFGTLVEAEKLIGEAHAVGLRVIIDIVPNHCSD
                     QHPWFQEALAGEGRDRFWFHEGDEPPNDWRSRFGGPAWSQAPDGSWYLHLYSPEQPDLN
                     WTNPRVRAEFESILRFWLDRGVDGFRIDVADGLVKDFSRPDAELPYSDQDGVHDIYRSW
                     RKVLDEYPDERVFVGEMWLPDPERFARYLRADELHSAFNFDFLCCPWESGELRRVIDGT
                     LAAHAPVGAPPTWVLSNHDVTRHVSRMGREDSSFDFGRRQHLTPTDLELGTKRARAAIM
                     LTTALPGCVYVYQGEELGLEEVDDLPDELREDPVWVRSGHTDRGRDGCRVPIPWGDDGP
                     SWLPRPEHWRSLSVAAQTAAPDSMLAHYRTVLALRRSEPSLGDGPMEWLELGPGVVAFR
                     RGDDFACVLNLSAEPVALPAHDAVLLSSGPLVDGAVPPDTAAWIRPAR"
     gene            complement(4282..5121)
                     /locus_tag="IOD16_RS26045"
                     /old_locus_tag="IOD16_25910"
     CDS             complement(4282..5121)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666446.1"
                     /locus_tag="IOD16_RS26045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25910"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_236594392.1"
                     /transl_table=11
                     /translation="MRTLIAPGRAGVGYKVALAVTTVILTAVFVVPLVWVVLSAMKPAV
                     ELARVPPTILPRTWTPGTYVEAWELMDLGRYFLNTIVVAVGVWAVQLAVDVPAAYALSR
                     LKPVLGKGILGMMLLTLMMPAAVLLVPTYLTIADLGLLNNPLALWLLGAANAFTVFLLK
                     RFFDQLPAEVLEAARIDGAGQFTMLWRIVLPLSRPILAVVSIFAVVAAWKDFIWPLLVF
                     SDPARQTLSVALQRFAPDTPVNLLLAGLVLSSVPMIGLFLVFQRHVLAGLTAGSVKG"
     gene            complement(5118..5987)
                     /locus_tag="IOD16_RS26050"
                     /old_locus_tag="IOD16_25915"
     CDS             complement(5118..5987)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333856.1"
                     /locus_tag="IOD16_RS26050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25915"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_201436496.1"
                     /transl_table=11
                     /translation="MRRRVAENLTAYGFLSAALICFAVFSWYPIARGAVLGFQQVDFVT
                     EPTWVGWENFERLFADPLFATAWRNTLLFTALALVFGFVVPFLLAVVLNELRHFKGYFR
                     LIVYLPVMLPPVVAALIWKWMYDPGPGLLNSALRGLGLEGAAWLDSADTSMLSLVIVAT
                     WANLGTATLIYLAALQSIPGDLYEAAELDGANVLRRLWHVTVPQTRFVLLVLLLLQVVA
                     TMQVFTEPYVMTGGGPEDSTVTVLLLLYRYAFYYNDFGTASALSLLLLLVLGAFTALYL
                     RVTRKADA"
     gene            complement(5987..7345)
                     /locus_tag="IOD16_RS26055"
                     /old_locus_tag="IOD16_25920"
     CDS             complement(5987..7345)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333857.1"
                     /locus_tag="IOD16_RS26055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25920"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_201436497.1"
                     /transl_table=11
                     /translation="MNSTSLRRAAGLLLAGSLSLAAVACSQADETGAAAGGKVTISVNG
                     QPPQTQPFDRKVFDEDVAEFEAANPDIDIEPHEGFMDPKTFSAKLAGGQLEDVFYAYFT
                     DPANLIARKQAADITDYVKDVPHYDAIRQELRDVFSKDGKVYGVPTANYSMGLLYNRAL
                     FTQAGLNPDQPPKTWDEVREAAKKITALGDGKVGFAEYSKNNQGGWHFTAWMYSVGGQV
                     ARQDGDKWVADFNNDKGREALQHLKDMRWADNTMGEKQLLVIEDVQQMMGAGQLGMYLA
                     APDNVPTLVNQFKGDYANYGLTGIPDGEGTLIGGEGYMLNPKATPEKIKAGLKWVQWKF
                     LNPDRFEKNLQRYKDQGQPIGLPVPPVADVWTGDIAAKQAQLKESLATVPVANFKSYVD
                     ATPKGRIEPPNAQQVYAILDNVMQAVLTNRDADISQLLADAEAKVNPVLAQVK"
     CDS             complement(7416..7493)
                     /gene="allorf_6238745_6238822"
                     /locus_tag="allorf_6238745_6238822"
                     /protein_id="allorf_6238745_6238822"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MEVGLSRVGVRGAAYELMSGSCEFS"
     CDS_motif       complement(7455..7493)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEVGLSRVGVRGA"
                     /locus_tag="allorf_6238745_6238822_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7416..7454)
                     /prepeptide="core"
                     /locus_tag="allorf_6238745_6238822_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.00"
                     /molecular_weight="1269.4"
                     /monoisotopic_mass="1268.5"
                     /core_sequence="AYELMSGSCEFS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEVGLSRVGVRGA"
                     /leader_location="[7454:7493](-)"
                     /alternative_weights="1287.4"
                     /alternative_weights="1305.4"
     gene            complement(7663..8664)
                     /locus_tag="IOD16_RS26060"
                     /old_locus_tag="IOD16_25925"
     CDS             complement(7663..8664)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012783748.1"
                     /locus_tag="IOD16_RS26060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25925"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_123746483.1"
                     /transl_table=11
                     /translation="MTQRRLAEVAAKVGVSEATVSRVLNGKPGVSDATRSAVLTALDVL
                     GYERPTQLRGERARLVGLVLPELQNPIFPAFADVVGNALAQRGFTPVLCTRTAGGVTEA
                     DYLELLFEQHVSGVVFAGGQYAQADASHEHYRQMTRRKLPAVLVNAAIDDLGFPRVSCD
                     DAVAVEQAFGHLVALGHTRIGAVLGPSDHMPSRRKLTALLSCASVAGVELFEEHAMFSL
                     EGGQAATTRLLHRGVTAILCASDPLALGAVRAVRRHGLKVPHDVSVVGYDDSPLMTCTE
                     PPLTTVRQPIEAMGRAAVELLANQIAGTPVPDEELLFEPELVVRSSTAPAPR"
     gene            complement(8661..9203)
                     /locus_tag="IOD16_RS26065"
                     /old_locus_tag="IOD16_25930"
     CDS             complement(8661..9203)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (5-168). E-value: 2e-12. Score:
                     38.9. Matches aSDomain: nrpspksdomains_IOD16_RS26065_ECH.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012596.4"
                     /locus_tag="IOD16_RS26065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25930"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_201436498.1"
                     /transl_table=11
                     /translation="MTVSLDVSGGIAVIRIDEPSDTVLAEVRAVLPVLAEARAVVLLVD
                     PGLCAAGTERLVRGSVAQREAVAAALRGVAGELVNLPVPVVAAIGGNPSGEAAELAMAC
                     DWRVLAADGGLGWVTDGRVTGDQVLVARRVTAEEALRTGLVDRVVPRCSVLRAAVELAN
                     ECKSTQTERKSCRIVAP"
     aSDomain        complement(8700..9188)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IOD16_RS26065_ECH.1"
                     /evalue="2.00E-12"
                     /label="IOD16_RS26065_ECH.1"
                     /locus_tag="IOD16_RS26065"
                     /protein_end="168"
                     /protein_start="5"
                     /score="38.9"
                     /tool="antismash"
                     /translation="DVSGGIAVIRIDEPSDTVLAEVRAVLPVLAEARAVVLLVDPGLCA
                     AGTERLVRGSVAQREAVAAALRGVAGELVNLPVPVVAAIGGNPSGEAAELAMACDWRVL
                     AADGGLGWVTDGRVTGDQVLVARRVTAEEALRTGLVDRVVPRCSVLRAAVELANECKST
                     "
     gene            9284..9838
                     /locus_tag="IOD16_RS26070"
                     /old_locus_tag="IOD16_25935"
     CDS             9284..9838
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS26070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_25935"
                     /product="hypothetical protein"
                     /protein_id="WP_201436499.1"
                     /transl_table=11
                     /translation="MKRWVVAVALVGLTGCAVPVAGQPTAGPVSSVPGTDAGPEVVRWM
                     NNFCGVAKYMVASGGVSFDQTQTDPAAAKKSVSDSLGRVIDVLDVVLHDLDELTPAPSP
                     AADTAVEVISEPLTRARDKFVSAKSTVDAAAEMTTDVFSTVIQDMTEAVTVMNEAVEKM
                     DVVSLPDEFRDAAARAENCAT"
     misc_feature    complement(9899..9910)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     gene            10001..12910
                     /locus_tag="IOD16_RS26075"
                     /old_locus_tag="IOD16_25940"
     CDS             10001..12910
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103770.1"
                     /locus_tag="IOD16_RS26075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25940"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_201436500.1"
                     /sec_met_domain="DUF4135 (E-value: 2.1e-105, bitscore:
                     351.8, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1e-28, bitscore: 99.0,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFPSAVDRPPAAWWLSGVRGNPQELVVPRGRPSWAAFVERATTTA
                     ARADFAGGGPTADADNPAEAFAHALRPLVRAAVALDPRLDADFAHALGRRLARIAARTL
                     VLELNLDRVGGRLVGDTPRERFADFVRGVDLPALFGRYPVLARLLGQACLHAVEAHGEL
                     LDRFAADRPEIVRTLLDGRDPGSLAQVETGRGDPHARGRSVAVLTFADGRRVVYKPRPV
                     ALHQAFADLVTWFDGHTGLGLRLPRVLARPGHGWLEFVEHRPCADVTEVGRFYQRLGAL
                     IALLYAVDGTDMHYENLVAAADQPVLVDVETLFHPTVGTATDPAVRALARSVHRTAVLP
                     RVLLGEHGALDVGGMGGDHGDRPPTEGVAWLHPGTDRMRLVRRPMPMPPAHNRPVVDGL
                     EAEPADYQGALLAGFRVGYDALCDHRADLLGPDGLLSAFADLPVRFVPRMTQLYATLLD
                     ESTHPDAVRGAADRQDVLDLLWDGTADDDVSRALVPHEMRDLWAGDVPLFTTRPGSRDV
                     WTSTGQRLPGLLPSCALDAVTAKVAALDEVDKHDQQWLISAGLASRPRPVDHRTGRGVA
                     SPVEAGVPDPQRLLVAACGIADEVLAHATTADGRVNWVGLELVDDRHWAVAPMGAGLSN
                     GYTGVALFLAQLGELTGAARYTEFARDAVRPIPGLLAAFAEDAGMAAAVGSGAFHGLGG
                     ISYALARLANLLHDDGIGDWLRSAVEVATAVEAIGEDPANVVEGWAGGLAAMLAVRAES
                     GLPAASALARAYADRLAAATPGGDGFARGRAGVGWALLRYARAAGDQRYGVVGRANLRA
                     DHALRQRLLDVTEADHSWCSGLSGAVLAHCAHPDQPVDAHTLHLDRCLNALAVHEPLRD
                     LSLCHGELGVIESLTVLAERGHGLAAAMRTRRAGLVLGALDQYGARCGTPGGVPSAGLL
                     TGLSGIGYGLLRLGFPERVPSVLLLGSTHDIDPLEEITR"
     gene            12907..13119
                     /locus_tag="IOD16_RS26080"
                     /old_locus_tag="IOD16_25945"
     CDS             12907..13119
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS26080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_25945"
                     /product="hypothetical protein"
                     /protein_id="WP_123746480.1"
                     /transl_table=11
                     /translation="MNDANRDEVTTWSEDQDGDHPAGEMALSRRAKAGARARALAGLTL
                     AVGAYAAVTVSESTMTTVSAPGLPL"
     gene            13209..16148
                     /locus_tag="IOD16_RS26085"
                     /old_locus_tag="IOD16_25950"
     CDS             13209..16148
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029579.1"
                     /locus_tag="IOD16_RS26085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25950"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_201436501.1"
                     /transl_table=11
                     /translation="MHTRAPVVVGRDEELHVLDRMLADAGTHRGRAVFLVGEPGIGKTR
                     LARFAAGAAFDRGMRVLRGRGSTIGPIVPFRPLAEALMSLLRAGDGLDLRELGPYRSAL
                     GRLAPDWSPESAGAEEQRPAHSVLVLAEAVLRLLAVVGRTRPCLLVLEDLHEADAETLA
                     VVDYLVDNLDQAPAALLVTTRADAGPTLDVVRSAAQRQAGVLVELRRLDERQVRRMVGL
                     CLEAEDHEVPAEVVRRLWADSAGNPFVVEEMLHGLVNGGLLVRGPGGWQVLGELRIDVP
                     SALVRLIAHRTDRLGPQGREVLSVAAVLGHRFPLPVLRRVTGMDDRALLSHLHAGVAAQ
                     LVTPDEPVPDWYAFRHPLTAEALLAQMPPPHRAELARRTADAVRELHPDLPGEWCALVA
                     SLRLDAGQTAEAGALLAEAGRRALAGGAAGSAVRLLDHAHRLLASEVDVAVRADVLDSL
                     LPALAEAGQFERAFALVDAVTELSAAGLGRVRRAELHTKLAQVANTAGRWTDGMAHVET
                     ARALLGADATDEHTARLDAVAAFLTLNLEVPDRIESAEFLARRAADAAKRVPLPEVGCE
                     TWQLLGVLARDRDLDEAAECFTRARALAEEHGLPIQRAYAVIRQAGLDWLAEGTAAELA
                     EAREEALLIGAISVAYNVDAILGLDTVLRGQYGAAAERLTRVVADTRRLQLRNLTLYGL
                     MAQATAAAHQGRRAEMDAAIEAFDEIGGVGSQERPLCFGLARAFCALLEEDRVAAGHDL
                     ARAVAHEAETPTVYHLSGRHGLQLLLDALSGALDLDGYRAVTRSAAARMRWNRGFAQFA
                     LAVLLGRLGREAEAAQAVRAGREAAAIHPLARHLGLRLVAEAAVADGWGEPVSWLRGAE
                     EYFHQAGQPAVASACRGLLRQVGASVPQRRTGSDQVPRELRALGVTVREFEVFRLLAGR
                     LGNKAIATRLHISPRTVEKHVASLIAKTARPDRESLSAFAASLGPADRP"
     gene            16209..16895
                     /locus_tag="IOD16_RS26090"
                     /old_locus_tag="IOD16_25955"
     CDS             16209..16895
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /GO_function="GO:0016018 - cyclosporin A binding [Evidence
                     IEA]"
                     /GO_process="GO:0000413 - protein peptidyl-prolyl
                     isomerization [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103774.1"
                     /locus_tag="IOD16_RS26090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25955"
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_201441580.1"
                     /transl_table=11
                     /translation="MAVLGGGVAQASPGTPDAGTPGTTRGPCAYTVTPDEPAARPVPLP
                     PDPRHTPDRGHPEVLLQTNQGPVPLVLDRAKAPCTVQSFLHLVRKKFYDDTTCHRLTAY
                     PTLKVLQCGDPANTGEGGPGYRYGDELPTDLAPVPNDPTGLRRVYPRGTLAMANAGPDT
                     NGSQFFLVTSDSVLRPNYTVFGRITPAGLATLDEVAAGGIVPNPDSEVDGRPALTTDVE
                     RAKRTR"
     gene            complement(16892..17617)
                     /locus_tag="IOD16_RS26095"
                     /old_locus_tag="IOD16_25960"
     CDS             complement(16892..17617)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS26095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_25960"
                     /product="hypothetical protein"
                     /protein_id="WP_201436502.1"
                     /transl_table=11
                     /translation="MRRSVVALLLAGVALAGCAERTALPAPALGPAVDDSATLITGLAA
                     RADEQGTVRFATETTMTGRRVTLDGGLLRAREGRLVSLRQDSSTDVVVLADAGYSRTEG
                     GTWTRLDLADRAPVRADTTVAGLADEVDPASVVESLAGSLLVEQRDEELDGVSTRRYTL
                     LVDLRSQAERTPGSSRRAQLLAAYESGFTASATVWVGPGDLPVRVEQVLKTLEDNVFQR
                     TLHRFTDWNADIRVSAPVS"
     gene            17714..18367
                     /locus_tag="IOD16_RS26100"
                     /old_locus_tag="IOD16_25965"
     CDS             17714..18367
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0043546 - molybdopterin cofactor binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017984003.1"
                     /locus_tag="IOD16_RS26100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25965"
                     /product="MOSC domain-containing protein"
                     /protein_id="WP_201436503.1"
                     /transl_table=11
                     /translation="MPHVLSVNVGSRVEFDQAAVGHTGIGKRPAPGPVEVRAPGPVGSG
                     LVGDHISDDRRHGGDDQAVYAYAREDLDAWAVELGRADLRPGLFGENLTTAGVDVCGAR
                     IGERWRIGGLLLQATSPRVPCRTFAGVMEEDAWMKTFTRRGLPGTYFRVLEPGTITAGD
                     EIVIEHRPDHGVTIAFAFRALTLEPASLPDVLAAGDDLTEDLRRRVERRTSDPA"
     gene            complement(18397..19236)
                     /locus_tag="IOD16_RS26105"
                     /old_locus_tag="IOD16_25970"
     CDS             complement(18397..19236)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015804023.1"
                     /locus_tag="IOD16_RS26105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25970"
                     /product="aldo/keto reductase"
                     /protein_id="WP_201436504.1"
                     /transl_table=11
                     /translation="MSETFSLGGDLTVNRLGYGAMRLTGEGIWGYPADRDNAIALLRRV
                     VELGVNFIDTADSYGPHINEELIRQALHPYADDLVVATKGGLLRTGPNEWPMLGKPAYL
                     RQAVETSLVRLGIERIDLYQLHRVDPDYPLEDQVGELRKLQEEGKIRHIGLSEVDVEQL
                     EAARAVAPIVSVQNLYNLANRGHEAVLDRCTELGIAFIPWFPVATGELARPGGVLDAAA
                     KEHGATPAQLALAWLLRKSPVVLPIPGTSSIAHLEENVAAARIELTDEEFEKLSALA"
     misc_feature    19196..19211
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.47"
                     /tool="antismash"
     gene            complement(19368..21392)
                     /gene="paaZ"
                     /locus_tag="IOD16_RS26110"
                     /old_locus_tag="IOD16_25975"
     CDS             complement(19368..21392)
                     /codon_start=1
                     /gene="paaZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR02278"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005168076.1"
                     /locus_tag="IOD16_RS26110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25975"
                     /product="phenylacetic acid degradation bifunctional
                     protein PaaZ"
                     /protein_id="WP_201436505.1"
                     /sec_met_domain="TIGR02278 (E-value: 0.0, bitscore: 1013.5,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="Aldedh (E-value: 3.4e-59, bitscore: 199.4,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMLRSYVSGRWHAPSVEGAPLHDAVTGEEIARISSQGIDMAAAL
                     DHGRRVGGPALRELTFHQRAALLKALASHLREHRDELYALSARSGATRTDSLIDVDGGI
                     GVLFGYASKAKRELPNDHVYVDGDVEPLSKGGTFVGQHVATPLRGVAVQINAFNFPMWG
                     PLEKFAPAFIAGVPSLIKPASQTAYLTEKLVELMLASDLLPEGSLQLVTGGAGDLLDHL
                     TGQDLVGFTGSASTARKLRTHPTVVRNSVRFNAEADSLNCSILGPDAVEGTPEFDLFVK
                     QLVSEMTVKAGQKCTAIRRALVPASLLDAVADAAAARLAKVVIGNPATEGVRMGALAGL
                     EQREEVRRSLKALMEVGEVVYGSPDRVDVVDADAERGAFLSPVLLKADPDHAQPHEVEA
                     FGPVSTLMAYRDAGHAVELAARGAGSLVGSVVTHDTDFARDVVLGVAPWHGRVLVLDRD
                     DAKESTGHGSPLPMLVHGGPGRAGGGEEMGGIRGVLHHMQRTAVQAGPRVLSAVTGRWV
                     TGAPRTETDVHPFRKSLRELRIGDTVVAGPRAVTLADIEHFAEFTGDTFYAHMDEEAAA
                     ANPFFGGRVAHGYLVVSFAAGLFVSPEPGPVLANYGLENLRFLTPTFPGDELTVTLTAK
                     QITPREDQEYGEVRWDADLVNQKGESVAKYDVLTLVAKQ"
     misc_feature    complement(21433..21448)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.08"
                     /tool="antismash"
     misc_feature    21487..21503
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.05"
                     /tool="antismash"
     gene            21531..22778
                     /locus_tag="IOD16_RS26115"
                     /old_locus_tag="IOD16_25980"
     CDS             21531..22778
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020664563.1"
                     /locus_tag="IOD16_RS26115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_25980"
                     /product="glycoside hydrolase family 16 protein"
                     /protein_id="WP_201436506.1"
                     /transl_table=11
                     /translation="MRTRVVVSAVVLALSGLVGPAAQAGPAPAPAPGAADVGAMAVTFA
                     EEFNGSAGTRVDASKWNTEVGDNNGNNREHQYYTTSASNAAMDGAGNLVITARKENPGN
                     YNCWYGRCQYTSARINTAGKFTTTYGKVEARMKMPRGKGIWPAFWMLGQDINSGNPWPN
                     SGEIDIMEFLGHDLDTVYGTIHGPGYSGAGGVGAAFNGPNFADGFHTFAIEWSPTGIAW
                     SVDGNVYQRRTPADVSGKQWVFNKPFFIILNLAVGGEWPGYPDASTTFPQQFVIDYVRV
                     STADGNPPAGGRITGIGGKCVDVAGANSANGTPVQLYDCNGTAAQQWSRPGDGTIRALG
                     KCLDAASGGTADGTLVQLWDCNGSGAQKWAVSGANDIVNIQANKCLDAQNNSSANGTRL
                     QLWTCLGSANQKWAVA"
ORIGIN
        1 cgaaccggtg gaagctcgac acgccgaact tcgtgtgcac gccgacgaag acgcgccggc
       61 gcgccgaggc cagggcctgc gccttgaccg cgcccaccgc cgggtccggc gtggtgagcc
      121 cgtgctcgcg ggagatgccg ttcgccccga tgtaggcgag gtcgatcacc atctccgaga
      181 gcatccgcgt ggcccagtgg tcgacggtgg ccagcgtccg gccgcgcacc cggccgccga
      241 gcagcagcac ggtcgcggac ggcacctccg acagcacggc ggcggtgggc agggacgcgg
      301 tgatcaccgt gagcggccgg ccggtgggca gtgcctcggc gacgagctgc ggcgtgtagc
      361 cctcgtcgat gaagaccgtc tcggcgtcac cgagccggtc cgcggcggcc cgggcgatgc
      421 gccgcttctc cggcaccatc gacgcggacc ggaacttcag gcccgtctcg tagccggcgc
      481 tctccaccgg gaacgcgccg ccgtgcgtgc ggcggaccag gccgtgctcg tccagcaggc
      541 gcaggtcgcg tcgcacggtc tcctgcgcga cctccagctc ggccgcgatc tcggccacgt
      601 cgacccggcc gtccgcccgt gcccgggcca ggatccggcg cttgcgctcg tccgcccgca
      661 cgtcacctcc ctgcccgctc ggaccgtcgc tgcccgttcg ggccgcgcct aaggtgtaac
      721 accggccgat tggtgtggcc accgccacag ccaggtgaac gatgcccggg ttccgcccgc
      781 ttagcctgac cgaacacaca cgatcgagtg aatccgtgcc cgaacgggcc tcacttcctg
      841 cccgttcaca ccccagaacg cacggcgagg cccccgagtt cgcgcgactc gggggcctcg
      901 tcgtcgtccc actgttcaac tcgggtgtcc tgaacgtagg actctcgcgt cctgaacgta
      961 ggactcgcgc gagagtcgta cgttcgcgcc gcgcgtgtcc tacgaccgga acgcgcgtgt
     1021 cctacgttcg gaacacccga gttgaccgct cggaacagcc ggtcaggcgt tcacgctggt
     1081 cagggccggg tagtcggtgt agccctgctc cgcgccgccg aagaacgtcg actggtccgg
     1141 cgtgttgaac gggccgccgt tcgccaggcg ggcgggcagg tccgggttgg ccaggaacag
     1201 cgcgccgaag ctcaccgcgt ccgccacgcc ctcgtccagc agggacaggt ggtccgggcc
     1261 ggtcacgccg tccggcgtgt gcgggttgag gatcagcacg ccggagaacc gctcgcgcag
     1321 ctccagcgtc aacgcccggt cgccggcctc gccgatgtgc aggtaggcca ggccgaacgg
     1381 ctcgatcgcg tcgaccaggg ccgggtacag ctcggcggtc gtctcctcgg cgatgtcgtt
     1441 gtaccggttg aacggcgaga tccgcaggcc cacgcgggcg ccgccgatcg cctcggccgt
     1501 ggcgcgcacg acctcgacgg tgaaccggat gcggttctcc accgagccgc cccactcgtc
     1561 gtcgcgcagg ttggtgttgt cggccaggaa ctggtgcagc aggtagccgt tggcgccgtg
     1621 cagctcgatc ccgtcgaacc cggcgtcgac ggcccggcgc gcggcggcgg cgaagtcggc
     1681 gatggtggcc tcgacgtcgg ccgggcccag ctcgaccggc gtgacgagct cggtcatccc
     1741 ctcgccggtg tacagctggc ccgccgcgcg caccggtgac gccccgacgg ggtgcaggtc
     1801 gccgggcagc aggctcgggt ggccgatccg gccggagtgc atgagctgcg cgaagatccg
     1861 gccgcccgcc tcgtgcaccg cgtcggtgac gacgcgccag ccggcgacct gctcgtcggt
     1921 gtgcagcccc ggcgtgtgcg ggtagccctg gccgaccgcg gacggctgga tgccctcggt
     1981 gatgatcagc ccggcgctgg cccgctgggc gtagtactcg gccatcacgg gcgtcggcac
     2041 cgtgtcgtac gcgcggctgc gagtcatcgg cgacatcacg atccggttgg ccaacttggt
     2101 gccggcgagg tcgagcggct cgaacgcggt gctcatgtct tcctccaggt tgcggtatta
     2161 cctgtccgaa cagctaacaa cacggagtgc attccgatgt ttcactgtga cagcgctcac
     2221 gatcccgggc ggctagactc gaaccatggc ctcgaccgga caaaatccca cgtcagcgcc
     2281 catgctccag atcgatgagg acgggcgcgt cagccacgcg atcttccgcg tcgcccgcct
     2341 gcaccgcatg ctcgcgggtc agctgctcag gcaggcaggc ctgcaccccg gacaggaaat
     2401 ggtcatgatg cgcctctggg accgcggtcc gcagcggcag tcggacctgt gcggcgagct
     2461 gggcgcggac tcgccgacca tgaccaggac cgtgcagcgg ctggaacgcg cgggcttcgt
     2521 gcgccgctca cccgacccga ccgacggccg cgccgtgctc gtcgagccga ccgccgccag
     2581 ccaggcgctg cggcaccagg tcgagcgcat gtggcgcgag ctggaggaag ccaccctcgg
     2641 cgacatggac gaagaccagc aggccgagac cctgagggtg ctcggcctgc tggagtgcaa
     2701 cttggcggtc cgggcgaaca agcccgtcgg tcggcctagc gggcaggcct gatccaggcc
     2761 gcggtgtccg gcggcacggc gccgtccacg aggggcccgc tgctcagcag cacggcgtcg
     2821 tgcgcgggca gcgcgaccgg ctcggcggac aggttgagca cgcacgcgaa gtcgtcgccg
     2881 cggcggaacg cgaccacgcc cggtccgagc tccagccact ccatcggccc gtcgcccagc
     2941 gacggctccg accgccgcaa cgccagcacg gtgcggtagt gcgcgagcat cgagtcgggc
     3001 gcggcggtct gcgcggccac cgacagcgac ctccagtgct ccggccgggg cagccacgac
     3061 gggccgtcgt caccccaggg gatcggcacc cggcacccgt cacggccccg gtcggtgtgg
     3121 cccgaacgca cccacaccgg gtcctcgcgc agctcgtcgg gcaggtcgtc cacctcctcc
     3181 agccccagct cctccccctg gtagacgtag acgcagccgg gcagcgcggt ggtcagcatg
     3241 atcgccgccc gcgcgcgctt cgtgcccagc tccaggtccg tcggcgtcag gtgctggcgc
     3301 cggccgaagt cgaacgacga gtcctcccga cccatccgcg acacgtgccg cgtcacgtcg
     3361 tggttggaca gcacccaggt cggcggcgcg ccgaccggcg cgtgcgcggc gagcgtgccg
     3421 tcgatgaccc gccgcagctc gccggactcc cacgggcagc acaggaagtc gaagttgaac
     3481 gccgagtgca gctcgtccgc gcgcaggtag cgggcgaacc gctccgggtc gggcaaccac
     3541 atctcgccga cgaacacccg ctcgtccggg tactcgtcga gcaccttccg ccacgagcgg
     3601 tagatgtcgt gcacgccgtc ctggtcggag tacggcagct cggcgtccgg cctggagaag
     3661 tccttgacca ggccgtcggc gacgtcgatg cggaacccgt cgacgccccg gtccagccag
     3721 aaccgcagga tcgactcgaa ctcggcccgc acccgcgggt tggtccagtt caggtccggc
     3781 tgctccgggc tgtacaggtg caggtaccac gacccgtccg gcgcctggct ccacgccggc
     3841 ccgccgaacc gcgaccgcca gtcgttcggc ggctcgtcgc cctcgtggaa ccagaaccgg
     3901 tcccggccct cccccgccaa cgcctcctgg aaccaggggt gctggtcgga gcagtggttg
     3961 ggcacgatgt cgatgatcac ccgcaggccg accgcgtgcg cctcgccgat cagcttctcc
     4021 gcctcgacga gcgtgccgaa caccggctcg atgtcgcggt agtcggcgac gtcgtagccg
     4081 ccgtccgcca acggggacgg gtaccagggg ctgagccaga tcgcgtccac acccaactcg
     4141 gcgaggtacg ggagcttctg gcgcagaccc gccagatccc cgatcccgtc gccgttgccg
     4201 tcggcgaagc tgcgcgggta cacctggtag atggccgcac cgcgccacca gttcatgtgg
     4261 attcctccct cggtgatgtg ttcagccctt cacgctgccg gcggtgagac ccgccagcac
     4321 gtgccgctgg aacaccagga acaggccgat catcggcacg ctggacagca cgaggccggc
     4381 cagcagcagg ttgaccgggg tgtcgggggc gaagcgctgc aacgcgacgc tgagcgtctg
     4441 ccgcgccggg tcggagaaca ccagcagcgg ccagatgaag tccttccacg cggccacgac
     4501 cgcgaagatg gacacgaccg ccaggatcgg ccgggacagc ggcagcacga tccgccacag
     4561 catggtgaac tggccggctc cgtcgatccg cgccgcctcc agcacctccg cgggcagctg
     4621 gtcgaagaac cgcttgagca ggaacacggt gaacgcgttg gccgcgccca gcagccacag
     4681 cgccaacggg ttgttgagca gcccgaggtc ggcgatcgtc aggtaggtcg gcaccagcag
     4741 caccgcggcg ggcatcatca gggtcagcag catcatgccg aggatcccct tgcccagcac
     4801 gggcttgagc cgtgacaggg cgtacgccgc gggcacgtcg accgcgagct gcaccgccca
     4861 cacccccacc gcgacgacga tcgtgttgag gaagtaccgg ccgaggtcca tcagctccca
     4921 cgcctcgacg tacgtgccgg gcgtccacgt ccgcggcagg atcgtcggcg gcacccgggc
     4981 cagctccacg gccggtttca tggccgagag cacgacccac accagcggca ccacgaagac
     5041 cgcggtgagg atgacggtcg tgaccgccag cgcgaccttg tagccgacgc cggctcgtcc
     5101 cggcgcgatc aacgtcctca cgcgtccgcc ttccgcgtca cccgcaggta cagcgcggtg
     5161 aacgcgccga gcaccagcag cagcaacagg ctcagggcac tcgccgtgcc gaagtcgttg
     5221 tagtagaagg cgtagcggta cagcaggagc agcacggtga ccgtggagtc ctcgggcccg
     5281 ccgccggtca tcacgtacgg ctcggtgaac acctgcatcg tcgccacgac ctgcaacagc
     5341 agcagcacca gcagcacgaa ccgggtctgc ggcaccgtga cgtgccacag cctgcgcagc
     5401 acgttcgcgc cgtccagctc ggccgcctcg tacaggtctc cggggatgct ctgcaatgcg
     5461 gccaggtaga tcagcgtggc ggtgcccagg ttcgcccagg tcgccacgat caccagcgac
     5521 agcatcgagg tgtcggcgct gtccagccac gccgcgccct ccagcccgag cccgcgcaac
     5581 gccgagttga gcaggcccgg gccggggtcg tacatccact tccagatcag cgcggccacc
     5641 accggcggca gcatcacggg caagtacacg atgagccgga agtagccctt gaagtgccgc
     5701 agctcgttga gcacgaccgc gagcaggaac ggcaccacga agccgaacac cagcgccagc
     5761 gcggtgaaca gcagcgtgtt gcgccacgcc gtggcgaaca gggggtcggc gaagagccgc
     5821 tcgaagttct cccagccgac ccacgtgggc tcggtgacga agtcgacctg ctggaagccg
     5881 agcaccgccc cacgcgcgat cgggtaccag gagaacaccg cgaagcagat cagcgcggcg
     5941 gacaggaacc cgtacgcggt caggttctcc gcgacgcggc ggcgcatcac ttgacctggg
     6001 ccaggacggg gttcaccttg gcttccgcgt cggccaggag ctggctgatg tccgcgtcgc
     6061 ggttggtgag caccgcctgc atgacgttgt cgaggatcgc gtacacctgc tgggcgttcg
     6121 gcggctcgat ccggcccttc ggggtggcgt ccacgtagga cttgaagttc gccaccggca
     6181 cggtcgccag gctctccttg agctgggcct gcttggcggc gatgtcaccg gtccagacgt
     6241 cggcgaccgg cggcacgggc aggccgatcg gctggccctg gtccttgtac cgctggaggt
     6301 tcttctcgaa ccggtccggg ttgaggaact tccactggac ccacttcagc ccggccttga
     6361 tcttctccgg cgtggccttc gggttgagca tgtagccctc gccgccgatg agcgtgccct
     6421 cgccgtccgg gatgccggtc aggccgtagt tcgcgtagtc gcccttgaac tggttgacca
     6481 gcgtcggcac gttgtccggc gcggccaggt acatgccgag ctggcccgcg cccatcatct
     6541 gctggacgtc ctcgatgacg agcagctgct tctcgcccat cgtgttgtcg gcccagcgca
     6601 tgtccttgag gtgctggagg gcttcacggc ccttgtcgtt gttgaagtcc gcgacccact
     6661 tgtcgccgtc ctggcgggcg acctggccgc cgacggagta catccacgcg gtgaagtgcc
     6721 agccgccctg gttgttcttg ctgtactcgg cgaaaccgac cttgccgtca ccgagcgcgg
     6781 tgatcttctt ggcggcctcg cggacctcgt cccacgtctt cggcggctgg tcggggttca
     6841 ggcccgcctg ggtgaacagc gcccggttgt agagcaggcc catcgagtag ttggcggtgg
     6901 ggacgccgta gaccttgccg tccttgctga agacgtcgcg cagctcctgc cggatggcgt
     6961 cgtagtgcgg gacgtccttc acgtagtcgg tgatgtccgc ggcctgcttg cgcgcgatga
     7021 ggttcgccgg gtcggtgaag taggcgtaga agacgtcctc gagctggccg cccgcgagct
     7081 tcgcggagaa cgtcttgggg tccatgaacc cctcgtgcgg ctcgatgtcg atgtccgggt
     7141 tggcggcctc gaactcggcc acgtcctcgt cgaagacctt gcggtcgaac ggctgggtct
     7201 gcggcggctg gccgttgacg gagatcgtga ccttgccacc ggcggcggcg ccggtctcgt
     7261 cggcttgcga gcacgcgacg gcggccaggc tcaggctgcc tgccagcagc aaccccgccg
     7321 ctctgcggag gctggttgag ttcatggggg cggaccctcc tcgggtgtgg tgtggcgcac
     7381 acggtaagtc gccccaacac tccgccgcaa gatgtctacg aaaactcgca acttcccgac
     7441 atcaactcgt aagctgcccc cctcacccca acgcgcgaga gtcctacctc caacgcgcga
     7501 gagtcctacg tccacgcacc ccgagttcaa cgctcagcgc aggcggcgcc tgtcgtgagt
     7561 gttgaattca ggggtcgtga acgtaggact ctcgggttgt gaacgtagga ctctcgcgcc
     7621 cggaaggttg gactctcggg gcccggaggt tggactcccg ggtcagcggg gggcgggggc
     7681 ggtggaggag cggacgacca gctccggttc gaagagcagt tcctcgtccg ggaccggggt
     7741 gccggcgatc tggttcgcca gcagctccac ggcggcgcgg cccatcgcct cgatcggctg
     7801 gcggaccgtg gtcaacggcg gctcggtgca ggtcatgagc ggcgagtcgt cgtagccgac
     7861 cacggacacg tcgtgcggca ccttgaggcc gtgccggcgc acggcgcgca cggcgcccaa
     7921 cgccaggggg tccgaggcgc acaggatcgc ggtgacgccc cggtgcagca ggcgcgtggt
     7981 ggcggcctgc ccgccctcca gcgagaacat cgcgtgctcc tcgaacagct ccaccccggc
     8041 gaccgacgcg cacgacaaca acgcggtcag cttccgccgc gacggcatgt ggtccgacgg
     8101 gcccagcacc gccccgatcc gggtgtgccc cagcgccacc aggtgcccga acgcctgctc
     8161 gacggccacc gcgtcgtcgc acgacacgcg cgggaagccg agatcgtcta tggccgcgtt
     8221 caccagcacg gcgggcagct tgcgccgcgt catctgccgg tagtgctcgt gcgacgcgtc
     8281 cgcctgcgcg tactgcccgc cggcgaacac caccccggac acgtgctgct cgaacagcag
     8341 ctccaggtag tccgcctcgg tcaccccgcc ggcggtccgg gtgcacagca ccggcgtgaa
     8401 gccgcgctgc gccagcgcgt tgccgaccac gtcggcgaac gcggggaaga tcgggttctg
     8461 cagctccggc agcaccagac cgaccagccg ggcgcgttca ccgcgcagct gcgtcggccg
     8521 ctcgtacccg agcacgtcca gggccgtgag cacggccgag cgcgtcgcgt cggacacccc
     8581 cggcttgccg ttgagcaccc ggctgaccgt cgcctcgctc acgccgacct tcgcggccac
     8641 ttccgccaac cgccgttgcg tcatggagca actatacggc aggacttacg ttccgtttgc
     8701 gttgacttgc actcatttgc gagttcgacg gcggcccgca gcaccgagca ccgcggcacg
     8761 acccggtcca ccagcccggt gcgcaacgcc tcctcggcgg tcacgcgccg tgccaccagc
     8821 acctggtcgc ccgtcacccg accgtccgtc acccacccga gcccaccgtc ggcggccagc
     8881 acccgccagt cgcacgccat ggccagctcc gccgcctcgc cggacgggtt gccgccgatc
     8941 gccgcgacca ccggcacggg caggttcacc agttccccgg ccacgccgcg caacgccgcc
     9001 gccaccgcct cccgctgcgc caccgacccc cggaccagcc gttcggtgcc cgcggcgcac
     9061 aggcccgggt cgaccaggag cacgaccgcg cgggcctcgg ccagcaccgg cagcaccgcg
     9121 cgcacctcgg ccaggaccgt gtccgacggc tcgtcgatcc ggatgaccgc gatcccgccg
     9181 gagacgtcga gtgagacggt catgagccgc catcgtggcc gacggttccc ccggttgtca
     9241 tgttccaccc cactatcggg tgatggcggg gtacaaatcc cctgtgaagc ggtgggtggt
     9301 ggcggtggcg ttggtcggcc tgaccgggtg cgcggtgccc gtggcggggc agccgacagc
     9361 cgggccggtg tcgtcggtcc ccgggacgga cgccgggccc gaggtcgtgc gctggatgaa
     9421 caacttctgc ggcgtggcga agtacatggt cgcctcgggc ggggtgtcgt tcgaccagac
     9481 gcagaccgac ccggcggcgg ccaagaagtc ggtcagcgac tccctcggcc gggtgatcga
     9541 cgtgctcgac gtcgtcctgc acgacctgga cgagctgaca ccggccccgt cgcccgccgc
     9601 ggacaccgcg gtcgaggtga tcagcgagcc gttgaccagg gcgcgggaca agttcgtctc
     9661 ggccaagtcg acggtcgacg cggcggcgga gatgaccacc gacgtcttct ccacggtcat
     9721 ccaggacatg accgaggccg tcacggtgat gaacgaggcc gtggagaaga tggacgtggt
     9781 ctcgctgccg gacgagttcc gcgacgccgc cgcccgggcg gagaactgcg cgacctgagg
     9841 tccgaccgcg cgccacgccg tccgttcacc tccccgcaag gcgctggtga cctgcgacgg
     9901 aagccttttc cgcacatctg cggactcacg cccgcccact cgcaaatctg ggggcggtgc
     9961 ccccatgtgc gccgcggcac gcccgtgaca cgttgtgcgc gtgttcccct ccgccgtcga
    10021 ccggccgccc gcagcgtggt ggctcagcgg tgtgcgcggg aacccccaag agctggtcgt
    10081 cccccgtgga cggccctcat gggccgcgtt cgtggaacgc gccaccacga ccgcggcccg
    10141 tgcagacttc gccggcggcg ggccgaccgc cgacgccgac aacccggccg aggcgttcgc
    10201 gcacgcgctg agacccctgg tgcgcgcggc ggtcgccctc gaccccaggt tggacgccga
    10261 cttcgcccac gcgctgggca ggcggctggc ccggatcgcc gcgcgcacgc tcgtgctgga
    10321 gctcaacctc gaccgggtcg gcgggcggct cgtcggcgac acgccgcggg agcggttcgc
    10381 cgacttcgtc cggggtgtcg acctgcccgc gctgttcggc cggtacccgg tgctggcccg
    10441 gctgctcggc caggcctgcc tgcacgcggt cgaggcgcac ggcgagctgc tcgaccggtt
    10501 cgccgccgat cggccggaga tcgtgcggac cctcctcgac ggccgtgacc ccggctccct
    10561 ggcgcaggtg gagacgggcc ggggcgaccc gcacgcgcgg ggccgctcgg tggccgtgct
    10621 gaccttcgcc gacggccgcc gggtggtcta caagccccgg ccggtggcgt tgcaccaggc
    10681 gttcgcggac ctggtgacct ggttcgacgg gcacaccggc ctcggcctgc ggctgccgcg
    10741 ggtgctcgcc cggccgggcc acgggtggct ggagttcgtc gagcaccgcc cgtgcgcgga
    10801 cgtcaccgag gtcggccggt tctaccagcg gctcggcgcg ctgatcgcgc tgctgtacgc
    10861 ggtggacggc accgacatgc actacgagaa cctggtcgcg gcggccgacc agccggtgct
    10921 ggtggacgtg gagacgctgt tccaccccac ggtgggcacg gcgacggacc cggcggtccg
    10981 ggcgctggcc cggtccgtgc accgcaccgc cgtgctgccg cgggtgctgc tgggcgagca
    11041 cggcgcgctg gacgtcggcg gcatgggcgg cgaccacggc gaccggccgc cgaccgaggg
    11101 cgtggcctgg ctgcaccccg gcaccgaccg gatgcgcctg gtgcgcaggc ccatgccgat
    11161 gccgcccgcg cacaaccggc ccgtggtgga cggcctggag gccgagcccg ccgactacca
    11221 gggcgcgctg ctggccgggt tccgggtcgg ctacgacgcc ctctgcgacc accgggccga
    11281 cctgctcggc ccggacgggc tgctgagcgc cttcgccgac ctgccggtgc ggttcgtgcc
    11341 gcggatgacc cagctgtacg cgacgttgct ggacgagtcg acgcacccgg acgcggtgcg
    11401 cggtgcggcg gaccgccagg acgtcctcga cctgctgtgg gacggcacgg cggacgacga
    11461 cgtgtcacgc gccctggtcc cgcacgagat gcgcgacctg tgggcgggcg acgtgccgct
    11521 gttcaccacc cggccgggca gccgcgacgt gtggacctcg accgggcagc ggctgccggg
    11581 cctgctgccg tcctgcgcgc tggacgccgt cacggccaag gtcgccgcgc tggacgaggt
    11641 ggacaagcac gaccagcagt ggctgatcag cgccgggctg gcgagccggc cgcggccggt
    11701 cgaccaccgc accggccgcg gggtcgcctc gccggtggag gcgggcgtcc ccgacccgca
    11761 acggctgctg gtcgccgcgt gcggcatcgc cgacgaggtg ctcgcgcacg ccacgaccgc
    11821 cgacggccgg gtcaactggg tgggcctgga gctggtggac gaccggcact gggcggtggc
    11881 cccgatgggc gcgggcctgt ccaacggcta caccggcgtc gcgttgttcc tggcgcagct
    11941 cggcgagctc accggcgccg cccggtacac cgagttcgcg cgcgacgcgg tgcggccgat
    12001 ccccgggttg ctggccgcgt tcgccgagga cgccgggatg gcggcggccg tcggcagcgg
    12061 cgcgttccac gggctgggcg gcatctccta cgccttggca cggctggcga acctgctgca
    12121 cgacgacggg atcggcgact ggctgaggtc ggccgtggag gtcgcgaccg cggtcgaggc
    12181 gatcggcgag gacccggcca acgtggtcga gggctgggcg ggcggcctgg ccgcgatgct
    12241 ggcggtgcgg gcggagagcg gcttgcccgc cgcctcggcg ctggcccgcg cctacgccga
    12301 ccggctcgcc gcggccactc ccggcggcga cggcttcgcg cgcggccggg ccggtgtcgg
    12361 ctgggcgttg ctgcgctacg cgcgggcggc gggcgatcag cgctacggtg tggtcggccg
    12421 ggcgaacctg cgcgcggacc acgcgctgcg gcaacgcctg ctcgacgtga ccgaggcgga
    12481 ccacagctgg tgctccgggc tctccggcgc ggtgctcgcg cactgcgcgc acccggacca
    12541 gccggtcgac gcgcacaccc tgcacctgga ccggtgcctg aacgccttgg cggtgcacga
    12601 gcccttgcgc gacctgagcc tgtgccacgg cgagctgggc gtgatcgagt ccttgaccgt
    12661 cctcgccgaa cgcgggcacg gcctggccgc ggccatgcgc acccggcgcg cgggactggt
    12721 cctcggcgcg ctggaccagt acggggcgcg ctgcggcacg cccggcggcg tgccgtcggc
    12781 cggcctgctc accgggttgt ccggtatcgg gtacggcttg ctccgcctag gttttcccga
    12841 gcgggtgcct tcggtgctcc tgctcggatc aacgcacgac atcgaccccc tcgaggagat
    12901 cacccgatga acgacgccaa ccgcgacgag gtcaccacct ggagcgagga ccaggacggc
    12961 gaccaccccg ccggcgagat ggcgctgtcc cgcagggcca aggcgggcgc ccgcgcccgc
    13021 gcgctggcgg gcctgaccct ggccgtcggc gcgtacgcgg cggtgaccgt gagcgagagc
    13081 accatgacca cggtgagcgc gccgggcctg cccctgtaac cagcttcacc ctgccgccgg
    13141 actgcccgcc cacactgggg gtgcgggcag tttggcatgc ggccgatcgg cttgactaag
    13201 gtcggcgcat gcacacccgc gcgccggtcg tggtcggccg cgacgaagaa ctccacgtgc
    13261 tcgaccgcat gctggccgac gcgggcaccc accggggccg cgcggtgttc ctcgtcggcg
    13321 agccgggcat cggcaagacc cggttggcgc gcttcgccgc cggcgccgcc ttcgaccgcg
    13381 gcatgcgggt gctgcggggt cgcggcagca cgatcgggcc gatcgtgccg ttccggccgc
    13441 tggccgaggc cctgatgtcc ctgctgcgcg ccggggacgg gctcgacctg cgggaactgg
    13501 gcccgtaccg gtcggcgctc ggccggttgg cgcccgactg gagcccggaa tcggccggcg
    13561 ccgaggagca gcggcccgcg cactccgtgc tggtgctcgc cgaggccgtg ctgcggctgc
    13621 tggccgtggt cggccgcacg cgcccgtgcc tgctggtgct ggaggacctg cacgaggcgg
    13681 acgccgagac gctggcggtc gtcgactacc tggtggacaa cctcgaccag gcgcccgccg
    13741 cgctgctggt gaccacccgc gccgacgccg gccccacgct ggacgtggtc cgttcggccg
    13801 cgcaacggca ggcgggcgtg ctggtggagc tgcgccgcct ggacgagcgc caggtgcgcc
    13861 ggatggtcgg cctgtgcctg gaggcggagg accacgaggt gcccgccgag gtcgtgcggc
    13921 ggctgtgggc ggacagcgcg ggcaacccgt tcgtggtcga ggagatgctg cacggcctgg
    13981 tgaacggcgg cctgctggtg cgcgggccgg gcggctggca ggtgctgggc gaactgcgca
    14041 tcgacgtgcc gtcggcgctg gtccggttga tcgcgcaccg caccgaccgg ctggggccgc
    14101 aggggcgcga ggtgctgtcg gtggccgccg tgctgggcca ccggttcccg ctgccggtgc
    14161 tgcgccgggt gaccggcatg gacgaccggg ccctgctgtc gcacctgcac gccggcgtgg
    14221 ccgcgcagct cgtcacgccg gacgagccgg tgcccgactg gtacgcgttc cggcacccgc
    14281 tgaccgccga ggcgctgctg gcgcagatgc cgccgccgca ccgggcggag ctggcgcggc
    14341 ggaccgccga cgccgtccgg gagctgcacc ccgacctgcc cggcgagtgg tgcgcgctgg
    14401 tggcgtcgct gcggctggac gccgggcaga ccgccgaggc gggcgcgttg ctggccgagg
    14461 cggggcggcg ggcgctggcg ggcggcgcgg ccgggtcggc ggtgcggctg ctcgaccacg
    14521 cgcaccggct gctggccagc gaggtggacg tggcggtccg cgcggacgtg ctggactcgc
    14581 tgctgcccgc gctcgccgaa gcgggccagt tcgagcgggc gttcgcgctg gtcgacgcgg
    14641 tgaccgagct gagcgccgcc gggttgggcc gggtgcggcg ggccgagctg cacaccaagc
    14701 tggcgcaggt ggccaacacc gcgggccggt ggaccgacgg catggcgcac gtggagacgg
    14761 cacgcgcgct gctcggcgcg gacgcgaccg acgagcacac cgcgcggctc gacgccgtgg
    14821 ccgcgttcct gacgttgaac ctggaggtgc cggaccggat cgagtcggcc gagttcctgg
    14881 ccaggcgggc ggccgacgcg gcgaagcggg tgccgctgcc cgaggtgggc tgcgagacgt
    14941 ggcagctgct cggcgtgctg gcccgcgacc gggacctgga cgaggcggcc gagtgcttca
    15001 cccgggcgcg ggcgctggcc gaggagcacg ggctgccgat ccagcgggcg tacgcggtga
    15061 tccggcaggc cggcctggac tggctggccg agggcacggc ggcggagctg gccgaggcgc
    15121 gtgaggaggc gttgctgatc ggcgcgatca gcgtggccta caacgtggac gcgatcctcg
    15181 ggctggacac cgtgctgcgc ggccagtacg gcgcggcggc ggagcggctg acccgggtcg
    15241 tcgccgacac ccggcggttg cagctgcgga acctgaccct ctacgggttg atggcgcagg
    15301 cgacggcggc ggcgcaccag ggcaggcggg ccgagatgga cgccgcgatc gaggcgttcg
    15361 acgagatcgg cggggtcggc tcgcaggaac ggccgctgtg cttcgggttg gcgcgggcgt
    15421 tctgcgcgct gctggaggag gaccgggtgg cggccgggca cgacctggcg cgggccgtcg
    15481 cgcacgaggc ggagacgccg accgtctacc acctgtccgg tcggcacggg ttgcaactgc
    15541 tgctggacgc gttgtcgggc gcgttggacc tggacggcta ccgcgcggtg acgcggtcgg
    15601 cggcggcccg gatgcggtgg aaccgcggct tcgcgcagtt cgcgctggcc gtgctgctgg
    15661 gcaggctcgg ccgggaggcg gaggcggcgc aggccgtgcg cgcggggcgg gaggcggcgg
    15721 cgatccaccc gctggcccgc cacctggggc tgcggttggt ggccgaggcg gcggtcgccg
    15781 acgggtgggg cgagccggtg agctggctgc gcggcgccga ggagtacttc caccaggccg
    15841 ggcagcccgc cgtggccagc gcgtgccgcg gtctgctgcg gcaggtgggc gcgtcggtgc
    15901 cgcagcggcg gaccgggtcc gaccaggtgc cgcgcgagct gcgggcgctg ggcgtgaccg
    15961 tgcgcgagtt cgaggtgttc cggctgctgg cgggccgcct gggcaacaag gcgatcgcca
    16021 cccggctgca catctcgccg cgcacggtgg agaagcacgt ggccagcctg atcgcgaaga
    16081 ccgcgcggcc ggaccgggag tcgttgagcg cgttcgccgc gtcgctcgga cccgccgacc
    16141 ggccctagca aggcggtcgc gggtccgtta gacctggtgc ggtgagaatc ctggtggcag
    16201 tggcgctgat ggcggtcctg ggcggcgggg tggcgcaggc ctcccccggc acaccggacg
    16261 cgggcacgcc gggcacgact cgcgggccgt gcgcgtacac cgtgacgccg gacgagccgg
    16321 ccgcccggcc ggtgccgctg ccgcccgacc cgcggcacac gcccgaccgc ggccaccccg
    16381 aggtgctgtt gcagaccaac cagggccccg tgccgctggt gctggaccgc gcgaaggcgc
    16441 cgtgcaccgt ccagagcttc ctgcacctgg tgcggaagaa gttctacgac gacacgacct
    16501 gccaccggct cacggcgtac ccgacgttga aggtgctgca gtgcggcgac ccggcgaaca
    16561 cgggtgaggg cggtcccggc taccggtacg gggacgagct gccgaccgac ctggcacccg
    16621 tcccgaacga cccgaccggc ctgcgccgcg tctacccgcg cggcaccctg gccatggcca
    16681 acgcgggccc ggacaccaac ggcagccagt tcttcctggt cacgtcggac tcggtgctgc
    16741 ggccgaacta caccgtcttc ggtcgcatca cacccgccgg gctcgccacc ctcgacgagg
    16801 tcgccgccgg cggcatcgtg ccgaacccgg acagcgaggt cgacggccgc ccggccctga
    16861 ccacggacgt cgagcgggcc aagcgcaccc gctaggagac cggcgcgctc acccggatgt
    16921 cggcgttcca gtcggtgaag cggtgcaagg tgcgctggaa gacgttgtcc tccaacgtct
    16981 tcagcacctg ctccacccgc accggcaggt cgcccggacc cacccacacg gtggcggacg
    17041 cggtgaagcc cgactcgtag gccgccagca gctgggcgcg ccgcgagctg ccgggcgtgc
    17101 gctcggcctg cgaccgcagg tcgaccagga gcgtgtagcg gcgcgtcgac acgccgtcga
    17161 gctcctcgtc gcgctgctcc accagcaggc tgccggccag cgactccacc accgaggccg
    17221 ggtcgacctc gtcggccagg ccggcgaccg tggtgtccgc ccgcacgggc gcgcggtcgg
    17281 ccaggtcgag cctggtccag gtgccgccct cggtgcggga gtagccggcg tcggccagca
    17341 cgacgacgtc ggtggacgag tcctgccgca acgacaccag ccggccctcg cgggcgcgca
    17401 gcagaccgcc gtcgagggtg acgcgccgcc cggtcatggt ggtctcggtc gcgaaccgga
    17461 ccgtgccctg ctcgtcggcg cgggcggcca ggccggtgat cagcgtggcg ctgtcgtcca
    17521 ccgccgggcc gagcgccggc gccggcaggg ctgtccgctc cgcgcagccc gccagcgcca
    17581 ccccggccag cagcaacgcg acgacggacc tgcgcatgtc tccccccacg gacggtgaac
    17641 aaggcccatc ctcccccacc ggcgaccgat gaggagtgcg aaccccgaaa gtggctcggc
    17701 taccgtcgtg gtcatgcctc acgtgctctc cgtcaacgtc ggctcccgcg tcgagttcga
    17761 ccaggccgcc gtcggccaca ccggtatcgg caagcgcccg gcgcccggcc ccgtggaggt
    17821 ccgcgcgccc ggcccggtcg gcagcggcct ggtcggcgac cacatctccg acgaccgccg
    17881 ccacggtggc gacgaccagg ccgtttacgc ctacgcgcgg gaagacctcg acgcgtgggc
    17941 ggtggagttg ggtcgcgccg acctgcggcc gggcctgttc ggcgagaacc tgaccacggc
    18001 gggcgtcgac gtgtgcggcg cgcggatcgg ggagcggtgg cgcatcggcg ggctgctgct
    18061 gcaggcgacg agcccgcgcg tgccgtgccg gacgttcgcc ggggtgatgg aggaggacgc
    18121 gtggatgaag acgttcaccc gtcgcgggct gcccggcacg tacttccggg tcctggagcc
    18181 cggcacgatc acggccggtg acgagatcgt catcgagcac cggcccgacc acggcgtcac
    18241 gatcgcgttc gcgttccggg ccctgacgct ggagcccgcg tcgctgccgg acgtgctggc
    18301 ggccggcgac gacctgaccg aggacctgcg acgccgggtc gaacggcgga cgtccgaccc
    18361 ggcgtagccg gagccgcgcg aggcggctcc cggcgctcag gccagcgcgg acagcttctc
    18421 gaactcctcg tcggtcagct cgatccgcgc cgccgccacg ttctcctcca ggtgcgcgat
    18481 cgacgacgtg ccggggatcg gcagcaccac gggcgacttg cgcagcagcc acgccagcgc
    18541 gagctgcgcg ggcgtggcgc cgtgctcctt ggccgccgcg tcgagcacgc cgcccggacg
    18601 ggccagctcg ccggtcgcca ccgggaacca cgggatgaac gcgatgccca gctcggtgca
    18661 gcggtccagc acggcctcgt gcccgcggtt ggccaggttg tacaggttct gcacgctcac
    18721 gatcggcgcg acggcgcggg cggcctcgag ctgctcgacg tccacctcgg acagtccgat
    18781 gtgccggatc ttgccctctt cctgcagctt gcgcagctcg ccgacctggt cctccagcgg
    18841 gtagtccggg tcgacgcggt gcagctggta gaggtcgatg cgctcgatgc cgagccggac
    18901 gaggctggtc tccacggcct gccgcaggta cgcgggcttg ccgagcatgg gccactcgtt
    18961 cgggccggtg cgcagcaggc cgcccttggt cgcgacgacc aggtcgtccg cgtacgggtg
    19021 cagggcctgc cggatcagct cctcgttgat gtgcgggccg taggaatccg cggtgtcgat
    19081 gaagttgacg cccagctcga cgacccggcg cagcagggcg atcgcgttgt cgcggtcggc
    19141 cgggtacccc cagatgccct caccggtgag ccgcatcgct ccgtagccga ggcggttgac
    19201 ggtcaggtcg ccgcccagcg aaaaggtctc agacacctct ggtgctcctc gtgtgactca
    19261 ggtgttgcac ggtctctcct cgcgccaacc agacggagtg cgccggttgt tcccgttcgg
    19321 gttgatcatc tcggcgcacg tccacctggt ggacccctaa cggcccccta ctgcttggcg
    19381 acgagcgtga gcacgtcgta cttggcgacc gactcgccct tctggttgac caggtcggcg
    19441 tcccagcgga cctcgccgta ctcctggtcc tcgcgcgggg tgatctgctt cgcggtcaac
    19501 gtcacggtca gctcgtcgcc ggggaacgtc ggcgtgagga accgcaggtt ctccagccca
    19561 tagttggcca gcaccgggcc gggctcgggc gagacgaaca ggcccgcggc gaacgacacc
    19621 accaggtacc cgtgcgcgac ccggccgccg aagaacgggt tcgccgccgc ggcctcctcg
    19681 tccatgtgcg cgtagaacgt gtcgccggtg aactccgcga agtgctcgat gtcggccagc
    19741 gtcaccgcgc gcggcccggc caccaccgtg tcgccgatcc tcagctcccg caacgacttg
    19801 cggaacgggt gcacgtccgt ctcggtgcgc ggcgcgcccg tcacccaccg cccggtgacc
    19861 gcgctcagca cccgggggcc ggcctgcacc gccgtgcgct gcatgtggtg cagcacgccc
    19921 cggatgccgc ccatctcctc accgccgccc gcccggcccg gaccgccgtg caccagcatc
    19981 ggcagcggcg agccgtggcc ggtggactcc ttggcgtcgt cgcggtccag caccagcacc
    20041 cggccgtgcc agggggccac gcccagcacc acgtcccgcg cgaagtcggt gtcgtgcgtg
    20101 acgacggagc cgaccaggct gcccgcgccc cgcgcggcca gctcgaccgc gtgcccggcg
    20161 tcgcggtagg ccatcagcgt cgagaccggc ccgaacgcct ccacctcgtg cggctgggcg
    20221 tggtccgggt cggccttgag cagcaccggt gacaggaacg cgccgcgctc ggcgtcggca
    20281 tccaccacgt ccacgcggtc cggcgagccg tagacgacct cgccgacctc catgagcgcc
    20341 ttcagcgagc gccgcacctc ctcgcgctgc tccagcccgg ccagcgcgcc catccgaacg
    20401 ccctcggtcg cggggttgcc gatgacgacc ttcgccaggc gtgcggcggc ggcgtcggcg
    20461 acggcgtcca ggagggaggc ggggaccagg gcgcgccgga tcgcggtgca cttctggcct
    20521 gccttgaccg tcatctcgct gacgagctgc ttgacgaaca ggtcgaactc gggggtgccc
    20581 tcgaccgcgt ccgggccgag gatcgagcag ttcagcgagt ccgcctcggc gttgaaccgc
    20641 acgctgttgc gcaccacggt cgggtgggtg cgcagcttcc gggcggtgga cgcggagccg
    20701 gtgaagccga ccaggtcctg gccggtcagg tggtcgagca ggtcgcccgc gccgccggtg
    20761 acgagctgca gggagccttc ggggagcagg tccgaggcca gcatcagctc gaccagcttc
    20821 tcggtgaggt aggccgtctg ggaggcgggc ttgatcagtg acggcacccc ggcgatgaac
    20881 gcgggcgcga acttctccag cgggccccac atcgggaagt tgaaggcgtt gatctgcacg
    20941 gccacgcccc gcagcggggt ggcgacgtgc tggccgacga acgtgccgcc cttgctcagc
    21001 ggctcgacgt cgccgtccac gtagacgtgg tcgttgggca gctcgcgctt ggccttgctc
    21061 gcgtagccga acagcacgcc gatgccgccg tcgacgtcga tcagggagtc cgtcctggtg
    21121 gcgcccgatc gggcggacag ggcgtacagc tcgtcgcggt gttcccgcag gtgcgaggcg
    21181 agggccttga gcagggccgc gcgctggtgg aacgtcagct cccgcagcgc cggtccgccg
    21241 acgcgcctgc cgtggtccag cgccgccgcc atgtcgatgc cctgcgacga gatccgggcg
    21301 atctcctcgc cggtcaccgc gtcgtgcagc ggcgctcctt cgacggacgg ggcgtgccag
    21361 cgacctgaca cgtagctgcg cagcatggcc atcgggtgtc gacctcctcg tcgggccggt
    21421 gggtgtcccg gcatgacccg acagtaaagc cttcccactt tcatcgtgac ttgattcaag
    21481 gtcatgcagt aacttttgga ccggccgccg ccagagtgag aggagtgtcg atgaggacac
    21541 gagtggtggt gagcgcggtc gtgctcgccc tcagcgggct ggtcgggccg gccgcccagg
    21601 ccggccccgc ccccgccccc gcgccgggcg ccgccgacgt gggcgccatg gcggtgacct
    21661 tcgccgagga gttcaacggc tcggcgggca cgcgggtcga cgcctccaag tggaacacgg
    21721 aggtcggcga caacaacggc aacaaccgcg agcaccagta ctacacgacg tcggcgagca
    21781 acgcggccat ggacggcgcg ggcaacctcg tcatcaccgc gcgcaaggag aaccccggca
    21841 actacaactg ctggtacggc cggtgccagt acacctccgc ccggatcaac accgccggca
    21901 agttcaccac gacctacggc aaggtcgagg cgcggatgaa gatgccgcgc ggcaagggca
    21961 tctggcccgc gttctggatg ctgggccagg acatcaactc cggcaacccg tggccgaaca
    22021 gcggcgagat cgacatcatg gagttcctgg gccacgacct ggacaccgtg tacggcacca
    22081 tccacggtcc cggctactcc ggcgcgggcg gcgtgggcgc cgccttcaac gggccgaact
    22141 tcgccgacgg cttccacacc ttcgccatcg agtggtcgcc gacgggcatc gcgtggtccg
    22201 tggacggcaa cgtctaccag cgccgcacgc ccgccgacgt gagcggcaag cagtgggtgt
    22261 tcaacaagcc gttcttcatc atcctgaacc tcgcggtcgg cggcgagtgg ccgggctacc
    22321 cggacgcgag caccacgttc ccgcagcagt tcgtgatcga ctacgtgcgc gtgtcgacgg
    22381 cggacggcaa cccgcccgcc ggcggccgga tcaccggcat cggcggcaag tgcgtggacg
    22441 tggccggcgc gaactccgcc aacggcacgc ccgtgcagct gtacgactgc aacggcaccg
    22501 cggcccagca gtggtcgcgg ccgggtgacg gcacgatccg cgcgctgggc aagtgcctgg
    22561 acgcggcgtc gggcggcacg gcggacggca cgctggtcca gctgtgggac tgcaacggga
    22621 gcggcgccca gaagtgggcg gtgagcggcg ccaacgacat cgtgaacatc caggcgaaca
    22681 agtgcctgga cgcgcagaac aacagctccg ccaacggcac ccggttgcag ctgtggacct
    22741 gcctcggctc ggccaaccag aagtgggccg tggcgtgacc ggacccggca tgatcagggc
    22801 atgcacagcc tgatcagagc ggaagcggcc aaggccgacc acgaccgccg actctccccg
    22861 gcggtcgtgg cggcactggt cgaggcgggc gcgacgcgga tgctcgcgcc
//
