LOCUS       NZ_CP064192            45787 bp    DNA     circular CON 30-JAN-2024
DEFINITION  Saccharothrix sp. 6-C chromosome, complete genome.
ACCESSION   NZ_CP064192
VERSION     NZ_CP064192.1
KEYWORDS    RefSeq.
SOURCE      Saccharothrix sp. 6-C
  ORGANISM  Saccharothrix sp. 6-C
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharothrix.
REFERENCE   1  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Saccharothrix texasensis strain 6-C
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2020) College of Life Sciences, Chongqing
            University, University Town Road, Chongqing, Chongqing 401331, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 10:20:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,916
            Genes (coding)                    :: 7,819
            CDSs (with protein)               :: 7,819
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 41 of 97
            Pseudo Genes (incomplete)         :: 78 of 97
            Pseudo Genes (internal stop)      :: 6 of 97
            Pseudo Genes (multiple problems)  :: 27 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:34:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5828841
            Orig. end                         :: 5874628
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP064192.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..45787
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="T1PKS"
                     /region_number="30"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..45787
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..45787
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="False"
                     /core_location="[20000:25787](-)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..25787)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     misc_feature    complement(503..516)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    complement(707..721)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 26.66"
                     /tool="antismash"
     misc_feature    912..926
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.79"
                     /tool="antismash"
     misc_feature    1566..1575
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.67"
                     /tool="antismash"
     misc_feature    complement(1569..1583)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.54"
                     /tool="antismash"
     misc_feature    1688..1703
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     gene            1755..2159
                     /locus_tag="IOD16_RS24245"
                     /old_locus_tag="IOD16_24120"
     CDS             1755..2159
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS24245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_24120"
                     /product="hypothetical protein"
                     /protein_id="WP_201436287.1"
                     /transl_table=11
                     /translation="MNTKVASALLVLGLSASLVGCSSNEDKFVEELKAAGFTAVGEPRS
                     ESEKKSKKIGKRTVKSSQKTIEVTVRVKGCDLEFAKVSGQSGYWLDELHVNGQEPDWPG
                     YPENLKQQDVVAAFAGSQPKPDGFKDCYQP"
     misc_feature    complement(1756..1770)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.01"
                     /tool="antismash"
     gene            2381..>2923
                     /locus_tag="IOD16_RS40620"
                     /pseudo=""
     CDS             2381..>2923
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222253.1"
                     /locus_tag="IOD16_RS40620"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGLEGAERHAACLLAARAGDRRALDAVIADLTPLVWHVARGHGLD
                     RATAEDVVQTVWLALLRDLDRVADPRALAGWLVVTARREAKRTWTPARREASVSDDTAE
                     LVGEYGLPEDAVLLDGRDRRLWRAFGRLSQRCQELLRLGALAGRAGAEAPAAPRGSLGP
                     SRGRCLDVLRAHLDAETG"
     misc_feature    3225..3240
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.01"
                     /tool="antismash"
     misc_feature    complement(3226..3239)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.54"
                     /tool="antismash"
     gene            3307..4236
                     /locus_tag="IOD16_RS24255"
                     /old_locus_tag="IOD16_24130"
     CDS             3307..4236
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS24255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_24130"
                     /product="hypothetical protein"
                     /protein_id="WP_201436288.1"
                     /transl_table=11
                     /translation="MRELTSTVTVDHSDRLRSIPDTRRDRTIHLRFLRLADGYLAQAWG
                     SAFPHDGGGHQGRVLLGASTLEAGIDDLRARWRAALTDEGAGPTGRPFVDEWDLAGRDV
                     DEAVRSLARAGHDLFALLFRHGDAGLDELRDRLVAAMRAGEHVVTVESDDLRVPWGLLY
                     VPLDDHAPVWDDGHRWDPRGFWGYRHLIEHTSSRATGADPTVPPGGAGLGAAPSGPDHL
                     GRREVGDPLPHRAAGCPVEAQVDPPRAFAREYAARLAEALSAPGATLGDVVRDLARAFL
                     DEHRNPLGLIFSLRRGIDAHVSSATTDR"
     misc_feature    4398..4411
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            4464..4676
                     /locus_tag="IOD16_RS24260"
                     /old_locus_tag="IOD16_24135"
     CDS             4464..4676
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS24260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_24135"
                     /product="hypothetical protein"
                     /protein_id="WP_201436289.1"
                     /transl_table=11
                     /translation="MSTPTETKIDFVDENTETVETVQGDGTAAPVAPETTPEQPGHEHH
                     HHRLENGELSPLCSGGGCVDSPPAK"
     misc_feature    complement(4730..4743)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.88"
                     /tool="antismash"
     gene            4760..7375
                     /locus_tag="IOD16_RS24265"
                     /old_locus_tag="IOD16_24140"
     CDS             4760..7375
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015104564.1"
                     /locus_tag="IOD16_RS24265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24140"
                     /product="CHAT domain-containing protein"
                     /protein_id="WP_236594335.1"
                     /transl_table=11
                     /translation="MPEPASADEAAVIREARELHRRGVDASCVGRHQEAARLLRRGQDL
                     ANTIDPVDPVVRSEWLATRIRLASTVAAEMAETSGPTAGLAGLAEARRLIEDVPDPVVK
                     AELRGRVEHNRGLLLLNAGFIEDAITAFDTALEHKERRLAAGGTVSVLVDLVVKTLRSR
                     GTAHTRLGSVRQARLDLTRAVALATEHGLPDRAADANHALGLLDLRVGDVPAALRRYQL
                     IERSYRQHELDVPVLLGLNRAQALMSAGLADEAGDQLDTLLPEMRAEQSVTRDLADVEL
                     YRAVAAYMTDDLDLARAMASSARRRMRRWGCETCVANATLIGLRVDTRLALRSGRVSRS
                     LPGRALAFADSLPVPRLAEQAALARMLAVRLEIRRGDVEAARSILDRVPRPGKLAPIDY
                     RMLRRLCRAELALALGRRAAALAEIRAGLTDLDHVRDRMGGLDLLSGTALHGRELAELA
                     VQLVLDGGHARRLFSWLERTRAQTYRYEPLTHLDNPELAERIAEVRSLTQSIHQAEHYG
                     HSTTALRGRRAERLREANRLGWHTGRWGRPRPVAGLTDVLARLGDRALVSFASSEDDLV
                     AVVVVGSDVRLARLGSAERAAESARMLNADLNALAPDHLPEPLVRVMSASARKQADRLD
                     AQLIRPLAELIGERELVIVPTGALYAVPWGVLPTLHGRPAVVAPSATAWLAADRAESRP
                     AGRAVLVRGPGLPAAVGEIDKLGAHYTTAALMSGRRASVATVLEALDGAGIAHLAAHGV
                     HEPENALFSRLELSDGPLYAHEMAGLAHPPRQVVLAACELALNRIRRGDEPLGFASALL
                     ASGSQLVVAPLSRVGDQACAAAMDDYHRSLAAGARPAVALADAIAVDPLRRPFVCLGSG
                     "
     gene            7691..8101
                     /locus_tag="IOD16_RS24270"
                     /old_locus_tag="IOD16_24145"
     CDS             7691..8101
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013868.4"
                     /locus_tag="IOD16_RS24270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24145"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_201436290.1"
                     /transl_table=11
                     /translation="MHGDGEQPPVTVEDAGDDGVVIAAVHGDLDVDSFRDVREALFTCL
                     NGRASALVVDLGDVGFFGSMGIAVLVEARQRADVVGAGFAVVAGRRTVARPIRMTDTED
                     LLRLHRTQDEALAAVRSRSGRGADAEFSWWSS"
     gene            8200..8430
                     /locus_tag="IOD16_RS24275"
                     /old_locus_tag="IOD16_24150"
     CDS             8200..8430
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033033.1"
                     /locus_tag="IOD16_RS24275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24150"
                     /product="hypothetical protein"
                     /protein_id="WP_123746765.1"
                     /transl_table=11
                     /translation="MTDEELVVEFALTRLDNPGLDLEEIAALVVRRGGHDRVVEFASRN
                     LATRGELRGAAFPSAVEHVLRVVLTLRGPAD"
     gene            complement(8486..9145)
                     /gene="lexA"
                     /locus_tag="IOD16_RS24280"
                     /old_locus_tag="IOD16_24155"
     CDS             complement(8486..9145)
                     /EC_number="3.4.21.88"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006282 - regulation of DNA repair
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="lexA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003103316.1"
                     /locus_tag="IOD16_RS24280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24155"
                     /product="transcriptional repressor LexA"
                     /protein_id="WP_201436291.1"
                     /transl_table=11
                     /translation="MTAYDDLDAFEHLDTSTLPPRQQRILAVIRDWVVRHGYSPSTREI
                     GDAVGLRSSSSVSKHLAALEEKGFLRRGAAVSRPMDVRLFLHRPPTRESADSVPVPVVG
                     HIAAGTPIAAEEHVDDVLTLPRELTGRGTVFGLRVRGDSMVDAAICDGDIVVVRQQHEA
                     HSGQIVAAMIDGEATVKVYRRRGGHVLLEPRNPAYDVIDGDRAEILGAVVSVLRSV"
     gene            9232..9903
                     /locus_tag="IOD16_RS24285"
                     /old_locus_tag="IOD16_24160"
     CDS             9232..9903
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (11-212). E-value: 1.2e-32. Score:
                     105.1. Matches aSDomain:
                     nrpspksdomains_IOD16_RS24285_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019819378.1"
                     /locus_tag="IOD16_RS24285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24160"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_201436292.1"
                     /transl_table=11
                     /translation="MPTLDRQDDVFTLDLGDDENRFHPDWIASVDAALGEVERAEGARA
                     LVTTATGKFFSNGLDLEWLVANGERHREYVVSVHGLFARVLSLPVITVAAIQGHAFAAG
                     AMLSLAHDFRVMRADRGYWCLPEAEIGIPFTPGMSALIQSRLTPRTAHEAMTTARRYGG
                     VAALDAGIVDHAVDEDAVRSTAAGIASAQAAKAGPTLGAIKARMYASTVDRLRDEDDPL
                     G"
     aSDomain        9265..9867
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IOD16_RS24285_ECH.1"
                     /evalue="1.20E-32"
                     /label="IOD16_RS24285_ECH.1"
                     /locus_tag="IOD16_RS24285"
                     /protein_end="212"
                     /protein_start="11"
                     /score="105.1"
                     /tool="antismash"
                     /translation="TLDLGDDENRFHPDWIASVDAALGEVERAEGARALVTTATGKFFS
                     NGLDLEWLVANGERHREYVVSVHGLFARVLSLPVITVAAIQGHAFAAGAMLSLAHDFRV
                     MRADRGYWCLPEAEIGIPFTPGMSALIQSRLTPRTAHEAMTTARRYGGVAALDAGIVDH
                     AVDEDAVRSTAAGIASAQAAKAGPTLGAIKARMYASTV"
     gene            complement(10033..11256)
                     /locus_tag="IOD16_RS24290"
                     /old_locus_tag="IOD16_24165"
     CDS             complement(10033..11256)
                     /GO_function="GO:0016772 - transferase activity,
                     transferring phosphorus-containing groups [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802865.1"
                     /locus_tag="IOD16_RS24290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24165"
                     /product="putative PEP-binding protein"
                     /protein_id="WP_236594336.1"
                     /transl_table=11
                     /translation="MSPREIPGVLLVGSPSTSVRGIANHTGRPLPGSVLVVEALGPELY
                     DTIVRSAAVVCSGGGRTGHMESLCRSRGIPVLRIPHAELVGLVGEVTVRTDRESVTLGE
                     SEVSVNSVEYPTVTPDDLRSVCVVIADATDIQSTNAIQPRVDQVTSFFIREEFVCLSSG
                     LSPLDALRAGIPEAERYGAAIGAELCAIVDQLVPGQRLVMRLLDLRSDDAAQITNDVDV
                     DHESNPELGLHGARWLLHEPNYPHAFRALRAHVREHLGPDFDRLNFAVPFINDQDEFLR
                     LRERLELPDDVPLSVFVETPAAVHSVTEFCEAGASEIFMGTKDLTQFYLAADRGNHRVA
                     SSYQTRHPAVMSGLRQSVEAGRRAGVPVHVFALGADVGYYFKHLPTDRFMMCTAELRQL
                     ALEAHESR"
     gene            complement(11542..13413)
                     /locus_tag="IOD16_RS24295"
                     /old_locus_tag="IOD16_24170"
     CDS             complement(11542..13413)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802864.1"
                     /locus_tag="IOD16_RS24295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24170"
                     /product="FAD/NAD(P)-binding protein"
                     /protein_id="WP_201436293.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.7e-09, bitscore:
                     36.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKSFGRFRRVVVVGAGLAGTATTIRFLRFAREPLEVVLVERRPE
                     YRSSGVAYQRESNHWHHVFNIQAGRMSAFREDVDDFIRWANHEADRSDWPADWRDFEFT
                     ESGPAPRRIYQDYLENRLAEAVREAATGVRLVEVDGEVVDVEVFDDHAHVVVEHLVEPL
                     GGGEDGHAVIEADHVVLATGLETKYPAFAAEVLEHPSFVRSPYSKSGIERLLGVRKDGV
                     VAIVGTLLSAYDSATLLLRRGHEGRIYMISGSGLTPRTYPPDHRHQVLELPAPQLLGDH
                     YEGREEFVRRFREEWDRACAVLTREHPEISPVVVTERVAKSWEPYLPAILERIPTDELR
                     ALLDGYGTLLAVLRVSAMSYTTDIVDAAMGEDKQIALTTGRVQHIRATGTGTLVLSVAD
                     RDSTRTIEADLVVSNFGRETNYERADSTLWSNLLRKEIAVPHRRTGRGVEVDPYGRLLG
                     PDGTPSGPVSVVGSPREGDEIVRNGRTGAFTFNLAAIKNHSVEVAATTLHRLESCYDVS
                     GGEIAGTVADAADPESRELVEHSVMLDVRRMAARHHDERQSLAARLEGNIQRLRELAAR
                     GGASPPSDRALRFAVSSAATTKLTDLSVTPRELRFLLGLEEAVEPVA"
     misc_feature    complement(13309..13311)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13787..14332)
                     /locus_tag="IOD16_RS24300"
                     /old_locus_tag="IOD16_24175"
     CDS             complement(13787..14332)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015100698.1"
                     /locus_tag="IOD16_RS24300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24175"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_236594337.1"
                     /transl_table=11
                     /translation="MAGDLFYQRGIRATGVDLVAAEAGVAPTTLYRLFASKDDLVGAYV
                     ELADLELRDRFTAAVEEAGPDPRDQILAVFDLMFAEVSSATFRGCKFLMSMAEFPEPGL
                     PAHRNALAAKSWTRARFRELTGKLGVEDPDALSDHLVLVFEGLHASGQSFGPDGPAKRG
                     RGLAEALLPAAAPRSGGT"
     gene            complement(14494..15492)
                     /locus_tag="IOD16_RS24305"
                     /old_locus_tag="IOD16_24180"
     CDS             complement(14494..15492)
                     /GO_function="GO:0016702 - oxidoreductase activity, acting
                     on single donors with incorporation of molecular oxygen,
                     incorporation of two atoms of oxygen [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015043.4"
                     /locus_tag="IOD16_RS24305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24180"
                     /product="carotenoid oxygenase family protein"
                     /protein_id="WP_201436295.1"
                     /transl_table=11
                     /translation="MERVDGVVGVVASVREVAEALVVRGALPAELDGALVWSGKYGVSG
                     VRLGPDGARWYRGPRPAALAPADWPSGATMARPVFDGQVWHTAMSHPDLGYAEHVTLGL
                     DGEVLRAEPFPLDGAPRMRAVGVTDRFVVVFDSAPYYSRAADLVGLRDPYSGPATGPTR
                     IGLLAYGRPLWFEVAEGEVLSLVNAYEDLGRVVVDAVWAPGVLRRHTLDLATGGVRRVE
                     LPAMDVGVVDERLAGRRHRFVFGTAGAAVVRHDVALGCTWRRELGVTPGQPVFVPSGED
                     EGQGWVVVVAGDEVLVLDAADLAGPPVAVVRLPFAVEASRCATWLAGGDAA"
     misc_feature    complement(15503..15516)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 18.37"
                     /tool="antismash"
     misc_feature    15565..15581
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: medium, score: 26.67"
                     /tool="antismash"
     gene            complement(15626..16237)
                     /locus_tag="IOD16_RS24310"
                     /old_locus_tag="IOD16_24185"
     CDS             complement(15626..16237)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666560.1"
                     /locus_tag="IOD16_RS24310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24185"
                     /product="hypothetical protein"
                     /protein_id="WP_201436296.1"
                     /transl_table=11
                     /translation="MTDDRAEPGARHLDVTRLPEDVVALLDALRPGESLVVTREGAPIA
                     TVTGTGARHVDRDREPSVRDVTVVATAMKLSRSARAALSAALGGDYIVLDLHAAPKTAD
                     VLLVPPGSPQLIGLLRSMFPQARVIVAEVEDDRLAVSFHGPVRRMLDAGADGYLTSTTI
                     PRLARQLDHDLTRRRPLAAGRAAPLGIEAAAVAPEPEDHP"
     gene            complement(16380..17918)
                     /locus_tag="IOD16_RS24315"
                     /old_locus_tag="IOD16_24190"
     CDS             complement(16380..17918)
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007031235.1"
                     /locus_tag="IOD16_RS24315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24190"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_201441544.1"
                     /transl_table=11
                     /translation="MDLLRERNDDLRDRAVSNAEAVRRQRSLGKHTARERLDMLLDKGS
                     FTEIELYRRHQAHGLKVSEHRPHTDGVVAGSGTIDGRRVFVYAQDFTIFGGSLGQAHAA
                     KIHKVMDMAIDTGSPIIALNDSGGARIQEGVMALDGYGGIFRRQVEASGVIPQIAVVLG
                     PSAGGAAYSPALADFTFMVRGTAQMYLTGPDVVQAVSGEKVTHDELGGASVHGELSGVA
                     SFVHDDEESCLEDVRYLVSMLPSNNLESPPAFEPVGAVDDVRPEFASIVPVEPNKPYDM
                     RTLIEELVDDGEFLEVHEGWARNVVVAFGRIDGAVVGLVGNQPLVFAGVLDIEASQKAA
                     RFVRFCDAFGIPLVSLVDVPGFLPGTAQEHAGVIRHGAKLLYAYCEASVPRIQVIVRKA
                     YGGAYIVMDSRSIGTDLALAWPTNEIAVMGAEGAVNVIFRKELAASADPDALRAELLAE
                     YSEQLVHPYYAAERGLVDDVIDPSHTRSAVARGLAMLRDKRRPTPARKHGNVPL"
     misc_feature    complement(17934..17953)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.22"
                     /tool="antismash"
     gene            complement(17984..19003)
                     /locus_tag="IOD16_RS24320"
                     /old_locus_tag="IOD16_24195"
     CDS             complement(17984..19003)
                     /NRPS_PKS="Domain: NAD_binding_4 (4-203). E-value: 1.4e-24.
                     Score: 78.5. Matches aSDomain:
                     nrpspksdomains_IOD16_RS24320_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228627.1"
                     /locus_tag="IOD16_RS24320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24195"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_201436297.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.5e-06, bitscore:
                     26.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 7.6e-11,
                     bitscore: 40.5, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.9e-22, bitscore:
                     78.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVTVTGGTGFVGSHTVAELVRAGHRVRLLVRDAGAVEAATRPLE
                     VPPDAVDVVVGDVTDEQSVAAAVRGADAVVHAASVYSFDRRRRAEMLRTNAHGTEVVLS
                     AARRAGAGRVVHVSSIAALFTPGVRVIREQSPVGTTREPYAATKAASEAIARRHQDEGA
                     PVVISYPPALLGPHDPKLGDQIDRLRNTVRGIMPMWPAGGLQIGDVRDTAALHAALLSP
                     DAAPGPVGRHFGPGHYLDMKEYLAGVREATGRALPAVFLPAAMMTPVGRLVDLVQPFWP
                     WHIPAEYGAIATVGAAVRVDPAASTFDLKPRPFADTVTDAVRWLADTGAVTDRQAGRR"
     aSDomain        complement(18395..18991)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IOD16_RS24320_NAD_binding_4.1"
                     /evalue="1.40E-24"
                     /label="IOD16_RS24320_NAD_binding_4.1"
                     /locus_tag="IOD16_RS24320"
                     /protein_end="203"
                     /protein_start="4"
                     /score="78.5"
                     /tool="antismash"
                     /translation="VTGGTGFVGSHTVAELVRAGHRVRLLVRDAGAVEAATRPLEVPPD
                     AVDVVVGDVTDEQSVAAAVRGADAVVHAASVYSFDRRRRAEMLRTNAHGTEVVLSAARR
                     AGAGRVVHVSSIAALFTPGVRVIREQSPVGTTREPYAATKAASEAIARRHQDEGAPVVI
                     SYPPALLGPHDPKLGDQIDRLRNTVRGIMPMWPAGG"
     CDS_motif       complement(18926..18991)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IOD16_RS24320_0001"
                     /evalue="2.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="IOD16_RS24320"
                     /protein_end="26"
                     /protein_start="4"
                     /score="10.4"
                     /tool="antismash"
                     /translation="VTGGTGFVGSHTVAELVRAGHR"
     gene            complement(19038..19544)
                     /locus_tag="IOD16_RS24325"
                     /old_locus_tag="IOD16_24200"
     CDS             complement(19038..19544)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101332.1"
                     /locus_tag="IOD16_RS24325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24200"
                     /product="flavin reductase family protein"
                     /protein_id="WP_123746757.1"
                     /transl_table=11
                     /translation="MRDMYESAPTMEETTLRDAMSLFATGVTVLTVGGEHAHGMTANAF
                     TSVSLDPPLVLACIAHSAVMHDAIANTKRFGVSIMGADQRDTAKYFADKRRPLGPEQFD
                     AVDWIEGPHSGAPLLNGSLAWLECELVQFYDGGDHTIFVGQVLRSSRGADASALLFYGS
                     SFHQV"
     gene            complement(19541..19999)
                     /locus_tag="IOD16_RS24330"
                     /old_locus_tag="IOD16_24205"
     CDS             complement(19541..19999)
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101331.1"
                     /locus_tag="IOD16_RS24330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24205"
                     /product="acyl-CoA thioesterase"
                     /protein_id="WP_123746756.1"
                     /sec_met_domain="4HBT_2 (E-value: 2.3e-12, bitscore: 46.3,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDYYEIRHTVGFEETNLVGNVYYVNYLRWQGRCREMFLKEKAPS
                     VLKDLQDDLKLFTLKVECEFFSEITLFDDLSVRMRLEELTQTQIQFSFDYVKVTAGQEV
                     LVAKGRQRIACMRGPNTNTVPSRVPEDLRKALAPYAEAPVLARAGLGG"
     gene            complement(20001..25787)
                     /locus_tag="IOD16_RS24335"
                     /old_locus_tag="IOD16_24210"
     CDS             complement(20001..25787)
                     /EC_number="6.4.-.-"
                     /GO_component="GO:0034081 - polyketide synthase complex
                     [Evidence IEA]"
                     /GO_process="GO:0030639 - polyketide biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Enediyne-KS) (5-464). E-value:
                     7.8e-99. Score: 323.4. Matches aSDomain:
                     nrpspksdomains_IOD16_RS24335_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (615-849). E-value: 2.4e-57.
                     Score: 186.5. Matches aSDomain:
                     nrpspksdomains_IOD16_RS24335_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_KR (1203-1384). E-value: 3.7e-29.
                     Score: 93.9. Matches aSDomain:
                     nrpspksdomains_IOD16_RS24335_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_DH (1462-1596). E-value: 2.7e-10.
                     Score: 32.8. Matches aSDomain:
                     nrpspksdomains_IOD16_RS24335_PKS_DH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     ene_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156126.1"
                     /locus_tag="IOD16_RS24335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24210"
                     /product="type I polyketide synthase"
                     /protein_id="WP_201436298.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.6e-54, bitscore:
                     182.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="ene_KS (E-value: 5e-253, bitscore: 838.4,
                     seeds: 19, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 3.2e-55, bitscore: 186.5,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSERIAIVGIGLRYPDAGSTGELWENVLAGRRAFRRLPDERMNQ
                     ADYYSPDPEAPDRFYTTKAAVLRDFEFDRVRYRVAGSTFRSTDLTHWLALDVTSQALAD
                     AGFPDGEGLPKRTTGVVLGNSLTGEFSRANVMRLRWPYVRRTVAAALTGKGWPEDEIAG
                     FLSQLEVDYKAPFPEINEDTLAGGLANTIAGRICNYFDLRGGGYTVDGACSSSLLSVAT
                     AAKSLVEGDMDVAIAGGVDLSIDPFEVIGFAKTGALAKRVMKVYDKDSNGFWPGEGAGS
                     LVLMREEDALAKGARIYATIAGWGVSSDGKGGITRPEADGHRLALHRAYGRAGYGLESV
                     SYFEGHGTGTALGDETEIEALSSARRTADPNARPAALSTVKGNFGHTKAAAGVAGLIKA
                     ALAVHHQVIPPGTGHYDPHPKLTADDAVMYVPVEAELWPDDQPVRAGVSAMGFGGINTH
                     IALEASPDAPRREQLDVRTKALVAGRQDAEVLLFDAPDRTTLKDRVAEVAALLPKLAFA
                     ELGDLAAALSARLGGASLRGAVVARTPEEAERKVERLMVAVSEGATLFDANDGVFLDDR
                     TTAPRLAFLFPGQGSGRGAVGAIRRRFPVAEEVFRTAGLPTDGDQVATEVAQPRIVAGS
                     LAALNVLRELGIEAHTAVGHSLGELSALHWGGALSANRVLSLAAERGRVMASAGKGGGA
                     MAGLGTTPERALELAAGEDVVIAGYNGPAQTVLSGPAEAVDRVCAVARAEGVQATRINV
                     SHAFHSPLVSPASAAMAERLVDFDFGRLIRPVHSTVTGEVLEAGADLRELLRDQITLPV
                     RFHEAAAKAAAVTDLVVEVGPGRVLTGLLEEIAPDKPVLSVDTDSGSLTSLLTVVAAAH
                     VLGAPVRTEVLFSDRVLRDLPLDGTMTFLASPCETAPALDSSLRSAERNASAAAKAAKP
                     ETAAGSDGESTLELLRRLAAQRVELPLDAITADTHPLDDLHLSSITVGQLVNEVTRSLG
                     RPALEGTTNFATVRMGELADLIDNLAETAHTDERDNGEVPGVAPWVRPFLVEHVERELV
                     AATPGAVGEWTVHAPEGHPLAEPLKAGLPGDGVLLLLPPEGGDAHVGLFLEAAHDVLAS
                     GRRLAVVQHKLGASGLARTLHLEAPHIPVTLVDLAPGLTGSEADVVRRVAAEVAATTGF
                     SQVRYDADGVRTVPVLRAVSGRVAPTPAEGSPLDSDDVLLVTGGGKGITAECAIAMATD
                     SGASLALIGRADPAADPELAANLARMTAAGIKHRYERADVTSAEQIAVAVAKFRAELGE
                     VTAVLHGAGRNEPKALTGLSEQDFHATLAPKIAGLTAVLDAVDQDRIKLLVTFGSIIGR
                     AGLRGEAHYSTANDWMSELTVDFGVKHPGARVLALEWSVWSGAGMGERLGVVEALMRDG
                     ITPISTDAGIAVLREVLADPTAGPVLVVSGRAAGLPTLEMSRTELPLARFVDRVLVHYP
                     AVELVTEADLSDGSDPYLGDHLLEGDLLFPAVIGMEAMTQVASALTGHDSPPLLEDVEF
                     LRPVVVRPGGSLTVRIAALARDAETVDVAIRAEDTGFSADHFRARLRFPRPAIPGDVVD
                     GAPVLPLVPVDPVTELYGSVLFQGKRFQRLQGYRRASARHAVAEVATTSVATWFAPFLP
                     QDRMLADPGTRDVMMHAIQCCVPDATLLPQSVERLYLAAPVDQLAQYVVLDARERSQDG
                     DSYTYDLDVRDPEGRLVERWEGLVLRAVRKRDGAGPWTPTMLGSYLERSLERVLGGSRA
                     IVVEPDPTDTSPEHRAQTALALSRALDRPVEVRYRPDGKPEVDGAEVSASHSAGVTFAA
                     AAPGGTLGVDVEEAVGRSEEDWAGLLGDDLIAVRDLLASEVGETAAIAGTRVWSALECL
                     RKTGSTTQALTVDRVHPDGWAVLSTGDAKVATWVTTVVDRAEPVVFAVLVGKEG"
     aSDomain        complement(21000..21401)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IOD16_RS24335_PKS_DH.1"
                     /evalue="2.70E-10"
                     /label="IOD16_RS24335_PKS_DH.1"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="1596"
                     /protein_start="1462"
                     /score="32.8"
                     /tool="antismash"
                     /translation="VELVTEADLSDGSDPYLGDHLLEGDLLFPAVIGMEAMTQVASALT
                     GHDSPPLLEDVEFLRPVVVRPGGSLTVRIAALARDAETVDVAIRAEDTGFSADHFRARL
                     RFPRPAIPGDVVDGAPVLPLVPVDPVTELY"
     aSModule        complement(21000..25772)
                     /domains="nrpspksdomains_IOD16_RS24335_PKS_KS.1"
                     /domains="nrpspksdomains_IOD16_RS24335_PKS_AT.1"
                     /domains="nrpspksdomains_IOD16_RS24335_PKS_KR.1"
                     /domains="nrpspksdomains_IOD16_RS24335_PKS_DH.1"
                     /incomplete
                     /locus_tags="IOD16_RS24335"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       complement(21309..21356)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IOD16_RS24335_0008"
                     /evalue="6.90E-03"
                     /label="PKSI-DH_m2"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="1493"
                     /protein_start="1477"
                     /score="9.1"
                     /tool="antismash"
                     /translation="YLGDHLLEGDLLFPAV"
     aSDomain        complement(21636..22178)
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IOD16_RS24335_PKS_KR.1"
                     /evalue="3.70E-29"
                     /label="IOD16_RS24335_PKS_KR.1"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="1384"
                     /protein_start="1203"
                     /score="93.9"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="VLLVTGGGKGITAECAIAMATDSGASLALIGRADPAADPELAANL
                     ARMTAAGIKHRYERADVTSAEQIAVAVAKFRAELGEVTAVLHGAGRNEPKALTGLSEQD
                     FHATLAPKIAGLTAVLDAVDQDRIKLLVTFGSIIGRAGLRGEAHYSTANDWMSELTVDF
                     GVKHPGARVLALEWSVWS"
     CDS_motif       complement(21708..21788)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IOD16_RS24335_0007"
                     /evalue="2.90E-05"
                     /label="PKSI-KR_m4"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="1360"
                     /protein_start="1333"
                     /score="16.6"
                     /tool="antismash"
                     /translation="LVTFGSIIGRAGLRGEAHYSTANDWMS"
     CDS_motif       complement(22083..22172)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IOD16_RS24335_0006"
                     /evalue="2.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="1235"
                     /protein_start="1205"
                     /score="10.4"
                     /tool="antismash"
                     /translation="LVTGGGKGITAECAIAMATDSGASLALIGR"
     CDS_motif       complement(23217..23243)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IOD16_RS24335_0005"
                     /evalue="9.90E+01"
                     /label="PKSI-KS_m3"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="857"
                     /protein_start="848"
                     /score="-3.3"
                     /tool="antismash"
                     /translation="PVLSVDTDS"
     aSDomain        complement(23241..23942)
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IOD16_RS24335_PKS_AT.1"
                     /evalue="2.40E-57"
                     /label="IOD16_RS24335_PKS_AT.1"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="849"
                     /protein_start="615"
                     /score="186.5"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="PTDGDQVATEVAQPRIVAGSLAALNVLRELGIEAHTAVGHSLGEL
                     SALHWGGALSANRVLSLAAERGRVMASAGKGGGAMAGLGTTPERALELAAGEDVVIAGY
                     NGPAQTVLSGPAEAVDRVCAVARAEGVQATRINVSHAFHSPLVSPASAAMAERLVDFDF
                     GRLIRPVHSTVTGEVLEAGADLRELLRDQITLPVRFHEAAAKAAAVTDLVVEVGPGRVL
                     TGLLEEIAPDKP"
     CDS_motif       complement(23571..23603)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IOD16_RS24335_0004"
                     /evalue="9.90E+01"
                     /label="PKSI-KS_m3"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="739"
                     /protein_start="728"
                     /score="-3.3"
                     /tool="antismash"
                     /translation="GPAEAVDRVCA"
     CDS_motif       complement(23730..23846)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IOD16_RS24335_0003"
                     /evalue="2.70E-10"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="686"
                     /protein_start="647"
                     /score="32.2"
                     /tool="antismash"
                     /translation="EAHTAVGHSLGELSALHWGGALSANRVLSLAAERGRVMA"
     aSDomain        complement(24396..25772)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IOD16_RS24335_PKS_KS.1"
                     /domain_subtypes="Enediyne-KS"
                     /evalue="7.80E-99"
                     /label="IOD16_RS24335_PKS_KS.1"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="464"
                     /protein_start="5"
                     /score="323.4"
                     /tool="antismash"
                     /translation="IAIVGIGLRYPDAGSTGELWENVLAGRRAFRRLPDERMNQADYYS
                     PDPEAPDRFYTTKAAVLRDFEFDRVRYRVAGSTFRSTDLTHWLALDVTSQALADAGFPD
                     GEGLPKRTTGVVLGNSLTGEFSRANVMRLRWPYVRRTVAAALTGKGWPEDEIAGFLSQL
                     EVDYKAPFPEINEDTLAGGLANTIAGRICNYFDLRGGGYTVDGACSSSLLSVATAAKSL
                     VEGDMDVAIAGGVDLSIDPFEVIGFAKTGALAKRVMKVYDKDSNGFWPGEGAGSLVLMR
                     EEDALAKGARIYATIAGWGVSSDGKGGITRPEADGHRLALHRAYGRAGYGLESVSYFEG
                     HGTGTALGDETEIEALSSARRTADPNARPAALSTVKGNFGHTKAAAGVAGLIKAALAVH
                     HQVIPPGTGHYDPHPKLTADDAVMYVPVEAELWPDDQPVRAGVSAMGFGGINTHIALEA
                     S"
     CDS_motif       complement(24717..24764)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IOD16_RS24335_0002"
                     /evalue="1.10E-02"
                     /label="PKSI-KS_m5"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="357"
                     /protein_start="341"
                     /score="8.8"
                     /tool="antismash"
                     /translation="YFEGHGTGTALGDETE"
     CDS_motif       complement(25134..25172)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IOD16_RS24335_0001"
                     /evalue="7.40E-03"
                     /label="PKSI-KS_m3"
                     /locus_tag="IOD16_RS24335"
                     /protein_end="218"
                     /protein_start="205"
                     /score="9.2"
                     /tool="antismash"
                     /translation="GYTVDGACSSSLL"
     misc_feature    complement(25983..25998)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            26226..27209
                     /locus_tag="IOD16_RS24340"
                     /old_locus_tag="IOD16_24215"
     CDS             26226..27209
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802838.1"
                     /locus_tag="IOD16_RS24340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24215"
                     /product="hypothetical protein"
                     /protein_id="WP_236594338.1"
                     /transl_table=11
                     /translation="MARTGTNRLVRREPASTTVATSSFVNGHFPRRRGLILVLSSIAGF
                     LLTVVWSAQFVDSTIGDSVANTLLGHDAKETPIQGIAAGIAFAFVSGIAGTFTACNIAA
                     FGAVAPMLGASGSRWSKLAATLKPVGWLAVGMIPVSALYGVLVGIVGTRMPQFATAANQ
                     PGTLSSRSIQSLIVFGVIGLVMVYLGLAALGYVRDPFRKIAKRFPNAPMVFMGVLIAGF
                     LIGRPFGLFRQMFRDAAESHNPLYGAAAFTLQSVGNIVIMALLFLALAYFTGGRLQRWL
                     SAKPSRIAAVTAAALIIAGVFTFMYWDIRMLARREIIPWYPTAPWA"
     gene            27235..28299
                     /locus_tag="IOD16_RS24345"
                     /old_locus_tag="IOD16_24220"
     CDS             27235..28299
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015100695.1"
                     /locus_tag="IOD16_RS24345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24220"
                     /product="cobalamin-independent methionine synthase II
                     family protein"
                     /protein_id="WP_201436299.1"
                     /transl_table=11
                     /translation="MGIPTEPIGSVPRPAELLKGFQDHAEGRIDAAALRALTDQALADT
                     VSRFEATGSPVVTDGEQDKPSFLTYPVAGIPDLAAGGAVVPFADGHTRELPVLTSGPFR
                     YSAHAVDLLRAAQQLTALPVKQPVIAPSALALLYPADGIDGYSRDEFVADLVNETEADI
                     RACLDAGAAVVQLDFTEGRLSLKLDPSGGLLRDFVALNNAVLDRFSAEDRARIGLHTCP
                     GGDQDSTHSADVDYADLLPDLFRIKAGRFYVQLASEPDRRRVLGIIKEHLPADARVFIG
                     VTDPIDPRVETAEEVRDRVLEAAEFLPVDRLGTCDDCGFAPFADDTSTSRDTAFAKIAA
                     RVEGTRLAEAALGI"
     gene            28561..29880
                     /locus_tag="IOD16_RS24350"
                     /old_locus_tag="IOD16_24225"
     CDS             28561..29880
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802840.1"
                     /locus_tag="IOD16_RS24350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24225"
                     /product="AarF/UbiB family protein"
                     /protein_id="WP_201436300.1"
                     /transl_table=11
                     /translation="MTKTTGRLVRLPGLVLRCAWVGAIVFCYGLLIAGSAVGARFRRSK
                     DGRGLRDGDRWVRMLTRLGPSYIKIGQLLSTRRDLLPEEVTTPLGRLTDGASPPRRRRI
                     ERAVRHAYRDRPWPFREFDWEPVASGSIATVHEAVTLDGRHVAVKVRRPGIERVMWQDF
                     TLTSSAMSLMGMLPKLRKMPFKLMHGQVGGAILRQLDFAAEAASLTALRANLEGGSRTV
                     TIPAPLPELCTPETVVMEFISDLRRFEPGELDLDTRRSVQRAVLGTVYEMLFIDGFVHC
                     DLHPGNLYFDLNADLVMLDAGFVIQLPDPVRRSFADFFINMAMGDGWMCAQIVIESAAE
                     IADDCDLEGFRAALGELVAETSGAKSGDFDLATFAGRLFDLQRRFGLFPAPEFAFPLLS
                     LLVIEGMIKGFDSDLDFQAEAIPVLRRRNIPRDAPSAVER"
     gene            29888..30493
                     /locus_tag="IOD16_RS24355"
                     /old_locus_tag="IOD16_24230"
     CDS             29888..30493
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802841.1"
                     /locus_tag="IOD16_RS24355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24230"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_123746752.1"
                     /transl_table=11
                     /translation="MDATTHVRVPLVDEGQAEGRLAELYADIKSNTNLPFVPDMFRLLS
                     TRPDLLEGVVAGYKGMFITGIMPRQTRELIAAWTSKVNQCPYCVGTHNFFFQAFGGPQE
                     TAQAVESAESVEDLPVDEKHKVLLRLLTKLSKEAYKITDVDWKLATDAGWTSEELLEGF
                     FIAGMFNFITRMVDGLGLGFSVAASRVSQQEVPTGGDA"
     gene            30490..31359
                     /locus_tag="IOD16_RS24360"
                     /old_locus_tag="IOD16_24235"
     CDS             30490..31359
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (21-170). E-value: 2.7e-11.
                     Score: 35.6. Matches aSDomain:
                     nrpspksdomains_IOD16_RS24360_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802842.1"
                     /locus_tag="IOD16_RS24360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24235"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_123746751.1"
                     /transl_table=11
                     /translation="MTASRAVLITGVNSSGGLSSGTGRATALRLHRAGWPVYATGRDLD
                     GLKDLAEEGITTLQVDVTDEESMVAAVERITEDHGAVGVLVNNAAYSLNGTIGETPIDQ
                     VRRQFETNFFGLSRMTQLVLPGMREQRSGRIIMMSSIFGLFATPGRGYYQATKHALEAI
                     SDSLRLEVKPWDIKVSIIEPSPILGSFVPTTVGDLGLDTDSDLYADFWERFVVWHGAYR
                     EVDKPKGRGRTAVRSGKVAETIEKAITDPNPRIRYRLGLPTHLLKPQRAIFGDRAWEVF
                     VTKFFPQP"
     aSDomain        30553..30999
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IOD16_RS24360_PKS_KR.1"
                     /evalue="2.70E-11"
                     /label="IOD16_RS24360_PKS_KR.1"
                     /locus_tag="IOD16_RS24360"
                     /protein_end="170"
                     /protein_start="21"
                     /score="35.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TGRATALRLHRAGWPVYATGRDLDGLKDLAEEGITTLQVDVTDEE
                     SMVAAVERITEDHGAVGVLVNNAAYSLNGTIGETPIDQVRRQFETNFFGLSRMTQLVLP
                     GMREQRSGRIIMMSSIFGLFATPGRGYYQATKHALEAISDSLRLE"
     gene            complement(31428..32975)
                     /locus_tag="IOD16_RS24365"
                     /old_locus_tag="IOD16_24240"
     CDS             complement(31428..32975)
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802843.1"
                     /locus_tag="IOD16_RS24365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24240"
                     /product="GMC family oxidoreductase N-terminal
                     domain-containing protein"
                     /protein_id="WP_201436301.1"
                     /transl_table=11
                     /translation="MTAQYDDIIVGAGSAGAALAARLTEDPARRVLLLEGGPDYVEPED
                     LPEEIFYGRAMSFDGNDWTFRADVHDGRRIRFPRGKLAGGSSAVGATVGLRGVAEDYDD
                     WAAAGNPGWSYEEVLPYFRKLENDYDFGDSEFHGGGGPMPIRRWRPEELSPGQTAFVEA
                     CLAAGFPEVKDHNHPDATGVGSIPSTRHDPVHRATTGTTYLRLIRQRPNLEIRAETSVD
                     RVVFDGAKAIGVMAAAKGGSYELVEGRRVILASGAVASPMILLRSGIGPAEDLRRLGID
                     VRADLSGVGGNLVDHQRTGAFLVPQPGVIDPTEAFLQQILRTTSPVTGEFNDLQYYMVN
                     HFSLAHFPELQMLAGATEILGVMVVSQRPGSRGRITLPSADPAAQPTIVLNFLDDEREM
                     DILVDGVRTAWKLAHHPDIMKLGQGFVVLRDAMIDNDDMVRQYVKTSLDSAYHPVGTVR
                     MGPASDPDSVVDERGAVHGTESLYVADSSIMPSTVRANTNLTSIMIGERMAAWLREG"
     misc_feature    33326..33341
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.19"
                     /tool="antismash"
     gene            33342..34334
                     /locus_tag="IOD16_RS24370"
                     /old_locus_tag="IOD16_24245"
     CDS             33342..34334
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802844.1"
                     /locus_tag="IOD16_RS24370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24245"
                     /product="DUF1702 family protein"
                     /protein_id="WP_236594339.1"
                     /transl_table=11
                     /translation="MSSSWGALRRRILTPNISATKLSVRGFHYKDETARELLETVGRSF
                     LEGYGYAAESREPLEAEQKLEKMPYKFRGFAYEGAGMGFAVRDALPFGRGGRTGRFLQG
                     RARNHDYMVLVGVGWAMARVPRSRWSKLGLDDPLLRWLALDGYGFHQAYFHTEKYVREQ
                     YREPAFPWPTDGSSWYSPRGIDQGIGRALWFVGGAEPKVVADLIESFAEERHADLYAGS
                     GLAATYAGGLPESELRWYADRVGPYLPNVAQGSAFAATARVDQGLVVDHTGVATKVFCD
                     MTPDEAAKLCHDTRPPAVAELPEQPGIPAFEVWRRRITATFTTDADVTT"
     gene            34331..35698
                     /locus_tag="IOD16_RS24375"
                     /old_locus_tag="IOD16_24250"
     CDS             34331..35698
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020629611.1"
                     /locus_tag="IOD16_RS24375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24250"
                     /product="cytochrome P450"
                     /protein_id="WP_201436302.1"
                     /sec_met_domain="p450 (E-value: 3.2e-89, bitscore: 298.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTDTAGARRAVPGPPRSETLSLLARMARDRLSVMTGVSQQYGD
                     AVRLRLGPKSMYFFNHPDHAKYVLADNPGNFVKGIGLVHARRALGDGLLTSEGELWKAQ
                     RKTIQPVFQAKRIAGKADVIAQEAAGLVAKLRGHRGGQPIDISEEMTGLTLGVLGRALL
                     DADLGAFESIGHSFEAVQNQAMFEMMSLSTVPHWVPLPIQRRFHRARADLDRIVAQLVE
                     ERRANPTADGDDILSRLVEATRNEPDPVVAHQRVRDEMVTLLLAGHETTASTLSWTFYL
                     ADKHPEVWERMHAEAVEVLGDRQPTFQDIPRLRYTTQVIQEVMRLYPPVWILPRVTREE
                     DVIGGYHVPAGADVLLCPYTLHRHPGFWDEPDTFDPDRFSPGRSSGRSRYAYIPFGAGP
                     RVCVGSGLGMMEATIVAASVVRELRLSTVPGYDVRGEPMLTLRVRGGLPMTVRSAA"
     gene            35986..37011
                     /locus_tag="IOD16_RS24380"
                     /old_locus_tag="IOD16_24255"
     CDS             35986..37011
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670848.1"
                     /locus_tag="IOD16_RS24380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24255"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_236594340.1"
                     /transl_table=11
                     /translation="MRAVRYGAAEQDVARVYRELERDFGVLAPPIALHASSPDVLAAAW
                     LMLRETLLVPGTASRAHKEAVSTAVSETNNCPFCVSMHSSMLIDLVGYRDGAIPDPGTR
                     AVAEWATANATPDGAAGHPVPFPASQGPEMIGTAVILQYLNRMVNIFLGELPLPPGAPA
                     ASMTVVRRVLVWLIKSAERRGPRPGASFDLLPDAPLPEDMKWAEGHAAIAGAYARAAAA
                     VDEAGRRSVPAEVRSLVLEHLARWDGKPMGVSRAWVEDAIAGLPEDQRDAGRLALLTAL
                     ASYQIDQSVLDRFRAGRPDDGSLIDLTSWSSLAAARRVGSWMTFRAQDEALPPAASSTH
                     E"
     gene            complement(37127..37351)
                     /locus_tag="IOD16_RS24385"
                     /old_locus_tag="IOD16_24260"
     CDS             complement(37127..37351)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS24385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_24260"
                     /product="hypothetical protein"
                     /protein_id="WP_201436304.1"
                     /transl_table=11
                     /translation="MRRAGSWKWVVGPAAVAALLVLVGAGGAIGWRVGRLVGAWIGAGA
                     GLLAAVLLLVVVDRFGSALAAPPDERHRS"
     gene            complement(37365..38174)
                     /locus_tag="IOD16_RS24390"
                     /old_locus_tag="IOD16_24265"
     CDS             complement(37365..38174)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1015: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802847.1"
                     /locus_tag="IOD16_RS24390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24265"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_201436305.1"
                     /transl_table=11
                     /translation="MQTAVERAIDTMWSRYHEPLSLADMADTAILSKFYFSRVFRTLTG
                     TSPGRFLTAIRLTKAKQLLLETSLSVTEISYMVGYNSLGTFTSRFTRSVGVPPARYRAL
                     SYGGILSPSSFSGPARGTQAGAVAGWVGVPETSTPVRVYVGAFKDPIAQGVPVACDIRD
                     GSGPYRLEALPEGRFYLRVAVVAVDDLDPNPSKRRPLFVGAAEAGSVRAGRTAEADIET
                     RSASTLDLPILLALPELDTREAPDVDLAVPAARTPLGRATPLDARAR"
     gene            complement(38310..39071)
                     /locus_tag="IOD16_RS24395"
     CDS             complement(38310..39071)
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005154151.1"
                     /locus_tag="IOD16_RS24395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_236594341.1"
                     /transl_table=11
                     /translation="MHDAVQRAITLMRTHYYEPLTLRDVAGAALVSPFHFSRLFHAAVG
                     VPPGRYLTAVRLFEAKRLLLTTWMNVADIVATIGYSSVGTFTTRFTRAVGLSPTQYRNP
                     AVSGLLAAVALPDFDNPLETGSSVFDAMPMPRFGGSGSVVGTLEVPAGDDESKVTVGLI
                     DDLIPCSVFASSTLVEGPLHHELVVGASATRCVAVALRAGNPRLSGSGLEFAGGIGHVI
                     ATGPGEHLRISVRMRERTPEPVAVAVGTGRR"
     misc_feature    complement(39445..39458)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 21.53"
                     /tool="antismash"
     misc_feature    39454..39469
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.58"
                     /tool="antismash"
     misc_feature    39999..40013
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     misc_feature    40036..40049
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            40910..41602
                     /locus_tag="IOD16_RS24400"
                     /old_locus_tag="IOD16_24275"
     CDS             40910..41602
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802848.1"
                     /locus_tag="IOD16_RS24400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24275"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_201436306.1"
                     /transl_table=11
                     /translation="MSPRKLDPETRATLVDIAARLLAEHGAEALSTRKIAAEAGTSTMA
                     VYTHFGSMSGLVREMVHEGFARLERQFSMVVRTDDPVADMAVLGYAYRQNAKANSHLYA
                     VMFGGQSLAGFSLTDEDRQYGRYTLLTVVECATRCIEAGRFRDGDPLLVAHEMWIATHG
                     LVNLELGGYLIDPVDADRCYDTILHSLLLGVGDDAQAVAASMAASKKRRAHEVEADPAP
                     AEPATTHR"
     gene            complement(41805..42506)
                     /locus_tag="IOD16_RS24405"
                     /old_locus_tag="IOD16_24280"
     CDS             complement(41805..42506)
                     /GO_function="GO:0015036 - disulfide oxidoreductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802856.1"
                     /locus_tag="IOD16_RS24405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24280"
                     /product="DUF899 domain-containing protein"
                     /protein_id="WP_201436307.1"
                     /transl_table=11
                     /translation="MSQLKVVSRQEWLEARKALLEKEKEVTRARDMIAEERRRLPMVKV
                     EKKYTFEGPGGSRLSLLDLFEGRRQLIVRHYMFSPGATEGCIGCSMQADSVGELSHMWA
                     RDTTFVMISRAPVADFTPFKERMGWNIPWYSSFGSDFNYDYEVSTDKGESPGVSSFYRD
                     GEDVFFTYSIFDRGGDIFKSFYNYLDITHLGRQEDQLEHPWDWWRFKDTYDVEDSHGPN
                     DNWWNGTRYKA"
     misc_feature    42674..42687
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.36"
                     /tool="antismash"
     misc_feature    complement(42675..42688)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.98"
                     /tool="antismash"
     misc_feature    complement(42684..42699)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     misc_feature    complement(42895..42909)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.98"
                     /tool="antismash"
     misc_feature    complement(43010..43022)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.2"
                     /tool="antismash"
     misc_feature    43211..43225
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.06"
                     /tool="antismash"
     gene            43271..43792
                     /locus_tag="IOD16_RS24410"
                     /old_locus_tag="IOD16_24285"
     CDS             43271..43792
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS24410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_24285"
                     /product="hypothetical protein"
                     /protein_id="WP_201436308.1"
                     /transl_table=11
                     /translation="MSALRASRRNYPEIVGRQSDTDGAYAVVRGPAGMGFVAGRGGQAH
                     RFANKNRLRNESHSRPGGIGRPVARVRWPGNGSREKFPFPAAGRDTGRGTWFVGESDAE
                     RVADLIDQCPERRDEAPRTAAPTGAPGTAAPFTGDVRAAPPVADGAAPVFETWRRRIAE
                     QVIHQEGVSL"
     gene            43789..45738
                     /locus_tag="IOD16_RS24415"
                     /old_locus_tag="IOD16_24290"
     CDS             43789..45738
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020629613.1"
                     /locus_tag="IOD16_RS24415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_24290"
                     /product="CRTAC1 family protein"
                     /protein_id="WP_201436309.1"
                     /transl_table=11
                     /translation="MTSTASWLRRQLPGVLALVLVAATFLVARLPEVSAEERQEVAAQF
                     GFQPESIALPGGYTQQTIRQVNQRYQHINAWISSVGSAVAINDLDGDGLSNDLCFVDVR
                     TDQVIITPAPEAGRTPRYEPFALSPGSLPMNDVMAPMGCVPGDYNEDGRIDLLIYMWGR
                     TPILHLAQAGATGMDEDTYEATELVPGKSSGTYDGPEWNSNSATVADFDGDGHADIFIG
                     NYFPHGPVLDPSKNTGVWMNDSMSAGFNGGEDYIFLSKGASGDTPKWEMSDPFPLEVSR
                     GWALASSSTDVNGDLLPELYVGNDFGPDRLLYNMSTPGNLKFEVVEGSKGPMEPKSKNV
                     GIDSFKGMGVDFGDLNGDQVFDMYVSNITASFGIEESHFAFMSQENNLSRVTSSLEDGD
                     AIWEDESAPLQLAWSGWGWDVKLSDLDNNAELEVLQATGFVKGDVNRWPQLQELATAND
                     TLLDDPMWWPIVGPGDDVGGNHHFHFFAKNKEGFYSDLSGDLGMAAPIPSRGIATGDVD
                     GDGKLDMAISRQWSDPVLFHNDGGSGNGFLGLRLTHDEQQTAGAFPGAGSPVIGAEVTI
                     TSSSGKKQINRVDGGSGHSGKRSHEVHFGLGTDNGPVQAHIKWRDRDGEIHEQDMTLNP
                     GWHDIQLGDQAKEK"
ORIGIN
        1 gctgcggaag ccggtgatcg agggagggcc ggaaccggcg tggtcgcgga tcaccgcgtt
       61 gaggtactgg gcggcggcgt gcagcgccag cggcaggcct cccagcgcca cggcgaggtc
      121 ccgggcctcc tgggaggtgc cgccgtcggg cacccgttcg gtcagcatgg aggcgccgtc
      181 gtcggggtcc agcggcggca ccgcgtgcac ggtcgcccag tcgccccaag tggcccgact
      241 gcggtcacgg ctggtgacca ggacccggcc gtgcggtgag gcgggtttgc gcaaccaccc
      301 cgtgccgtcg gacacctgct tggtcgtggg gtcgagcagt tgggggtcgt cggcgttgtc
      361 gaagacgagc agccacggct cgccggtcgc gtcgagcagg cgccacagca ggtcggccgc
      421 gctgcgcggg cccgcgtacc aggcggtctc cgcctcgtcg cgcggcgcgc cgagctggtt
      481 cgccacctcg cgcatggaga ggttgatccg gggcacctcg atccaccaga cccggtgtcc
      541 ggccttcttg gcgcgcgcgg cgacctcgag cgcgatccgg ctcttcccgg aaccgccgat
      601 gccgcccagc acgtgcacct tcgactgccg gtcgtagacg atggacgcga cgagcttgct
      661 gcgcccgtac agcttgggca ggccgtcgag ccgcggcgtg accgagacgg ccggtcggcc
      721 cgcgtccggc ttctcgacca cggtctcgga ggtcgcgacg gacggcgcgc cgccctggtt
      781 cagcacgtcg agcacgtgcc ctctcagcac gcggtaggac gaggacgccg agtcctccgg
      841 ctggatgatc gagaagtggt cgccgtccac catgccgctg ttgtggaaga gccaggcgct
      901 ggacctcggc gggacgatcc ggtcctgcag ccccccgtag gccgcgatcg gtatccgaca
      961 ggtcgactcg ctgacgcccg tggcgttgac gacggcgcgg aacaacgtcc gctgggtctc
     1021 cacgatcgcg gtgtcgaacg gccgcagttg cgcctcttgc gggttgttgg ggtaccacca
     1081 cttgcggatg ccgaggaaga actcggaacc gtcgttggga caggcgaaca tgacgacctg
     1141 cttgatcctg gccagcgact cgccctcgcc gcgccacagc gtcctggcca ggaaccgctg
     1201 ggtgatcagc ccgccctggc tgtgggtgac cagcaggatc gacgacgact cccccagctc
     1261 gtgccgcagg taggtgccga ggcggtcggc gatgtcgtcc gcggtcgcga tgcgccggtc
     1321 cggccggaag ctgaatctcg gcgaggggta ctcgaatagg tgggtgcgca cccgaccgga
     1381 gaagtccggg tcggtcgcga ccaggtgcgc gaaccggtcc caggtgcggc cggcggagaa
     1441 cagcccgtgc acgaataccg cgtcgaccgg ttcggaccgt gccatgggcc ctccgaatga
     1501 ctgaactccg cgcaaatacc cagaccatag ccctcgcgaa caggggcggt accgcagtat
     1561 tgcggcgttt ttcgaatggt gaccggacat tcgggccatc accggaattc acctccgacc
     1621 ggaatatcgt ccacttctcg gcgcttgccg ggcatggcgc ggtcgcgctt cggaactgcc
     1681 cttcgacgtc acagcgcggt aacggttggg tgaggtgggc gcggtggttt cggcggggcg
     1741 gtttgctgtg cgccatgaac acgaaggtcg cgtccgcgct gctggtgctg gggttgagcg
     1801 cctccctggt cgggtgctcc agcaacgagg acaagttcgt cgaggagttg aaggccgccg
     1861 ggttcaccgc ggtcggcgag ccgcgcagcg agtcggagaa gaagtccaag aagatcggca
     1921 agcggacggt caagtcctcg cagaagacca tcgaggtcac ggtgcgggtc aagggctgcg
     1981 acctggagtt cgcgaaggtg tccgggcagt ccggctactg gctggacgag ctgcacgtga
     2041 acggtcagga gccggactgg cccggctacc ccgagaacct gaagcagcag gacgtcgtgg
     2101 ccgcgttcgc gggctcccag ccgaagccgg acggcttcaa ggactgctac cagccctagc
     2161 ccgcgacggg cgagcggccc cgtccccggt cacgggggcg gggcttttcg ccgtcccccg
     2221 aaggcgtgtc cggcgaacac aggagttgtc caccgcacta gtgcgggcaa cttgtcgcgc
     2281 gctcgtggtg gtgtagcggt cgaacgcgcg gaatccgccc ggaaagggag tgggagcact
     2341 gcccggaaca ccgaccggct tcgaccccga gccccactgg ctgggcctgg agggggcgga
     2401 gcggcacgcc gcctgcctgc tcgccgcgcg cgccggcgac cgccgggcgc tggacgcggt
     2461 gatcgcggac ctgacgccgc tggtgtggca cgtcgcccgg gggcacgggc tggaccgcgc
     2521 caccgcggag gacgtggtgc agacggtctg gctcgccctg ctgcgcgacc tcgaccgcgt
     2581 cgccgacccg cgcgcgttgg ccgggtggct ggtcgtcacg gcgcgccgcg aggcgaagcg
     2641 gacctggaca ccggcccgcc gcgaggcgtc ggtgagcgac gacaccgcgg agctggtcgg
     2701 cgagtacggg ctgcccgagg acgccgtgct gctcgacggc cgggaccgcc ggctgtggcg
     2761 ggccttcggc cggctctccc agcgctgcca ggaactcctg cggctcggcg ccctggccgg
     2821 ccgggcgggc gccgaggcgc cggccgcgcc gcgcgggagc ctcggcccga gccgggggcg
     2881 gtgcctggac gtgctgcgcg cgcacctcga cgccgagacg gggtggccgg gcctgccctc
     2941 gcccgcgcgg ccgcagcacc cgccccgcga cccgcgggtg cggctgcgct ccgaccggcc
     3001 ggtggtcgcc ggtgcgccga cggaggtgga gttcggctac acggtggtcc gggacgccct
     3061 gacgacctcc gggcacgaca ccgcgcccgt gtcggcgccg gtccgcgtgc tgctgcacgt
     3121 cgagggcgcc accgtcgagc cgttgacgag ggtgttccgc ctgccggccg acgtcgacgc
     3181 ggaatcggtg cggttccgcg tggtgccggg ggcgcggggc acgctcgaac tcgtgttccg
     3241 ggtgtacctc ggcgacggac acctgctcca ggaggtccgc gccgacctgc cggtcggtga
     3301 ggcctgatgc gggagctgac gagcaccgtc acggtcgacc acagcgaccg gctccggtcc
     3361 atcccggaca cccgccgcga ccgcacgatc cacctccggt tcctgcgcct ggccgacggc
     3421 tacctcgcgc aggcctgggg cagcgcgttc ccgcacgacg gcggcggcca ccaggggcgc
     3481 gtgctcctgg gcgcgtcgac gttggaggcg ggcatcgacg acctgcgcgc gcggtggcgc
     3541 gcggcgctga ccgacgaggg cgcgggtccg accggccggc cgttcgtcga cgagtgggac
     3601 ctggccggtc gggacgtcga cgaggcggtg cggtccctcg cccgcgccgg ccacgacctg
     3661 ttcgccctgc tgttccgcca cggcgacgcg gggctcgacg agctccgcga ccgcctcgtc
     3721 gccgcgatgc gcgccggcga gcacgtcgtc accgtcgagt ccgacgacct gcgcgtgccc
     3781 tgggggctgc tctacgtccc gctcgacgac cacgccccgg tgtgggacga cgggcaccgc
     3841 tgggacccgc gcggcttctg gggctaccgc cacctgatcg agcacacctc ctcccgcgcc
     3901 accggagccg acccgacggt ccccccgggc ggggccgggc tcggggccgc cccgagcggc
     3961 cccgaccacc tcggccgccg ggaggtcggc gaccccctgc cgcaccgggc cgccggctgc
     4021 ccggtcgagg cgcaggtcga cccgccgcgc gcgttcgccc gcgagtacgc cgcgaggctg
     4081 gcggaggccc tctcggcgcc cggcgccacg ctcggcgacg tcgtccggga cctcgcccgc
     4141 gcgttcctgg acgagcaccg caacccgctc gggttgatct tctcgctgcg ccgcgggatc
     4201 gacgcgcacg tgtcgtcggc gacgacggac cggtgatcgg actacccgcc gtggttcgtt
     4261 acctgaatgg gtgacagttg agggtgttta cgcacggcag gagccgtatg cctacccgat
     4321 gtgcgaaatt ccctctcgat ggttacgccg ttgtgccact attaccctgt tcgagcggta
     4381 cgaggggtcc gctgaacttg actcagagca atcgtctgag tcgttgtaag gccaagacag
     4441 atcctcaggg gagggagatc gttttgtcga cgcccaccga gaccaagatc gacttcgtgg
     4501 acgagaacac cgagaccgtc gagaccgtcc aaggggacgg gaccgcggcc ccggtcgccc
     4561 cggagaccac gccggagcag ccaggacacg agcaccacca ccacaggctg gagaacggcg
     4621 agttgtcgcc gctgtgctcg ggtggagggt gcgtggactc gccgccggcg aagtgagctg
     4681 tcaaccgtga tcgagcccgt cgaccggatc tcctggtcgg cgggctttat cacgctgcgt
     4741 tgtgtgatgt catggaagtg tgcctgaacc cgcttccgcc gatgaagccg cggtcatccg
     4801 cgaagcacgc gaactgcacc gccgcggagt cgacgcctcg tgcgtcggcc ggcaccagga
     4861 agcggcccgg ttgctgcggc gcgggcagga cctcgcgaac accatcgacc ccgtcgaccc
     4921 ggtggtccgc tccgagtggc tcgccacccg gatccggttg gcctcgacgg tcgcggccga
     4981 gatggcggag acctcgggcc cgaccgccgg gttggccggg ctcgccgagg cgcggcggct
     5041 gatcgaggac gtgcccgatc ccgtggtgaa ggccgaactg cgcgggcggg tcgagcacaa
     5101 ccgcggcctg ctgctgctga acgcggggtt catcgaggac gccatcaccg ccttcgacac
     5161 cgcgctggag cacaaggaac gccgcctcgc cgcgggcggg acggtgtcgg tgctcgtcga
     5221 cctggtcgtg aagacgctgc ggagcagggg cacggcgcac acgcggctgg gctccgtgcg
     5281 ccaggcgcgg ctcgacctca ccagggccgt cgcgctggcc accgagcacg ggctgccgga
     5341 ccgcgcggcc gacgcgaacc acgcgctcgg cctgctggac ctgcgggtcg gcgacgtgcc
     5401 ggcggcgctg cggcgctacc agctcatcga gcggtcctac cggcagcacg agctggacgt
     5461 gccggtgctg ctcggcctga accgcgccca ggcgctgatg tccgcgggcc tggccgacga
     5521 ggcgggcgac cagctcgaca ccctgctgcc ggagatgcgc gccgagcaga gcgtcacccg
     5581 cgacctggcc gacgtggagc tgtaccgggc ggtggccgcg tacatgaccg acgacctcga
     5641 cctggcgcgc gcgatggcct cgtcggcacg gcggcggatg cgtcgctggg gctgcgagac
     5701 ctgcgtcgcg aacgcgacgc tcatcgggct gcgcgtggac acccggctcg cgctgcggtc
     5761 cggacgggtg tcccggtcgt tgcccggtcg cgccctggcc ttcgccgact cgctgcccgt
     5821 gccgcggctg gccgagcagg ccgccctcgc ccggatgctg gcggtgcggc tggagatccg
     5881 gcgcggcgac gtcgaggcgg cgcggagcat cctggaccgg gtaccgcggc ccgggaagct
     5941 cgccccgatc gactaccgga tgctgcgccg gctgtgccgg gcggagctcg ccctcgccct
     6001 cggccgccgg gccgccgcgc tcgccgagat ccgggccggc ctgacggacc tcgaccacgt
     6061 gcgcgaccgg atgggcggcc tcgacctgct gtccgggacc gcgctgcacg gccgggagct
     6121 ggcggagctg gccgtccagc tggtgctcga cggcggccac gcgcggcggt tgttctcctg
     6181 gctggagcgg acgcgggcgc agacctaccg ctacgagccg ctcacccacc tcgacaaccc
     6241 cgagctggcc gagcggatcg ccgaggtccg cagcctcacc cagtccatcc accaggccga
     6301 gcactacggc cactcgacca ccgcgctgcg cggccgccgg gccgaacgcc tccgcgaggc
     6361 caaccggctc ggctggcaca cgggccggtg gggcaggccg cggccggtcg ccgggctgac
     6421 cgacgtgctg gcgcgcctcg gcgaccgggc cctggtgagc ttcgcgtcgt ccgaggacga
     6481 cctggtcgcg gtggtcgtgg tcggctccga cgtgcggctg gcccggctcg ggtcggccga
     6541 gcgggcggcc gagagcgccc ggatgctgaa cgcggacctc aacgcgctgg cgcccgacca
     6601 cctgccggag ccgctggtgc gggtgatgtc ggcgtcggcg cgcaagcagg ccgaccggct
     6661 cgacgcgcag ctgatccgcc cgctggccga gctgatcggc gagcgcgagc tggtgatcgt
     6721 gccgaccggc gcgctgtacg cggtgccgtg gggcgtgctg ccgacgctgc acgggcggcc
     6781 ggccgtcgtc gcgccgtcgg ccaccgcgtg gctggccgcg gaccgggccg agagcaggcc
     6841 cgccggccgg gcggtgctgg tgcgcggccc cgggctgccc gccgccgtcg gcgagatcga
     6901 caagctcggc gcgcactaca ccaccgcggc gctcatgtcg ggccggcggg cgtcggtcgc
     6961 cacggtgctg gaggcgctgg acggcgcggg gatcgcgcac ctggccgcgc acggcgtcca
     7021 cgagccggag aacgccctgt tctcccggtt ggagctgagc gacggcccgc tctacgcgca
     7081 cgagatggcc ggtctcgccc acccgccccg gcaggtcgtg ctggccgcgt gcgagctcgc
     7141 cctcaaccgg atccggcgcg gcgacgagcc cctcggcttc gccagcgccc tgctcgccag
     7201 cggctcgcag ctggtggtgg ccccgctgag ccgggtcggc gaccaggcgt gcgccgccgc
     7261 gatggacgac taccaccgca gcctggccgc cggcgcgcgg ccggccgtgg cgctggcgga
     7321 cgcgatcgcg gtcgacccgc tgcggcggcc gttcgtgtgc ctcggcagcg gctgagccct
     7381 tcgccgggct cgtccgtcgc cgccgaggtg caccggctca ccgacctgcg cggtctggcc
     7441 ggcaccccgg gactcgccga cgcgccagtc ggtcgctcgt cgaccccggc gggctcgccc
     7501 tcgcgctggg cgcggccctc cggcccgacc tcgctcctcc ggggtgaggc gtcgctccct
     7561 tgaggacgga tgaggacgcc ggcccgccca cctcgacggc actggcggcg ctttggcggt
     7621 gtcggtcgcg cgtcgaacgg gtaatggtgg gagacggtgt cgcagccggg atcggggtga
     7681 gggagcggcc gtgcacggtg atggagagca gccgccggtg acggtcgagg acgcgggtga
     7741 cgacggtgtg gtgatcgccg ccgtgcacgg cgacctcgac gtcgacagct tccgcgacgt
     7801 gcgggaagcg ttgttcacct gcctgaacgg tcgcgcgtcc gcgctggtgg tcgacctggg
     7861 cgacgtgggg ttcttcgggt cgatgggcat cgcggtgctg gtcgaggcgc ggcagcgcgc
     7921 ggacgtggtg ggcgccgggt tcgccgtcgt ggcgggcagg cgcacggtgg cgcggccgat
     7981 ccggatgacc gacaccgagg acctgctgcg gctgcaccgc acccaggacg aggcgctggc
     8041 cgcggtgcgc tcccggtccg ggcggggcgc ggacgccgag ttctcgtggt ggtcgtcgtg
     8101 aggcggtccc ggacggagag gtccggtcgg ggcgggccgt gacggagaag tccgccggcc
     8161 ccggctcgac tactctcgga ggggtcggag ggagcggtcg tgacggatga ggagctcgtg
     8221 gtcgagttcg ccctgacccg gctggacaac cccggcctcg acctggagga gatcgccgcg
     8281 ctcgtggtgc ggcgcggcgg gcacgaccgc gtggtggagt tcgcctcgcg gaacctggcc
     8341 acgcgcggcg agctgcgggg cgcggcgttc ccgtccgcgg tcgagcacgt gctgcgggtc
     8401 gtgctgaccc tgcgcggccc cgccgactga cgcccgccgg acgcggcggt ccgccccggg
     8461 gccgcctcgc cgtggcgggc gggtgtcaga cgctgcgcag caccgagacg acggccccga
     8521 ggatctcggc ccggtcgccg tcgatgacgt cgtaggccgg gttgcgcggc tccaggagga
     8581 cgtgcccgcc gcgccggcgg tagaccttga cggtcgcctc gccgtcgatc atcgcggcga
     8641 cgatctgccc ggagtgcgcc tcgtgctgct gccgcaccac cacgatgtcg ccgtcgcaga
     8701 tcgccgcgtc gaccatcgag tcgccgcgca cccgcaggcc gaacacggtg ccgcgcccgg
     8761 tcagctcgcg cggcagggtc aggacgtcgt ccacgtgctc ctcggccgcg atgggcgtgc
     8821 ccgcggcgat gtggccgacc acgggcacgg gcacggagtc ggcgctctcc cgcgtcggcg
     8881 gccggtgcag gaacaggcgc acgtccatcg gccgggacac ggcggcgccg cgccgcagga
     8941 agcccttctc ctccagcgcc gccaggtgct tggacaccga ggacgacgac cgcaggccca
     9001 ccgcgtcgcc gatctcccgc gtgctcggcg agtacccgtg ccggaccacc cagtcgcgga
     9061 tcaccgcgag gatccgctgc tggcgcggcg ggagggtgga ggtgtccagg tgctcgaagg
     9121 cgtcgagatc gtcgtaggcg gtcacctgcg cgatcataga ggcgggctgg caccggccgc
     9181 gtccgagcac taagttaccg actggtagcg aaccggaccc cggaggaacc catgccgacg
     9241 ctcgaccgcc aggacgacgt gttcaccctc gacctcgggg acgatgagaa ccggttccac
     9301 cccgactgga tcgcctcggt cgacgcggcc ctcggcgagg tggagcgggc ggagggcgcc
     9361 cgcgccctgg tcaccaccgc caccggcaag ttcttctcca acggcctgga cctcgagtgg
     9421 ctggtggcca acggcgagcg ccaccgcgag tacgtcgtgt ccgtgcacgg cctgttcgcg
     9481 cgggtgctgt cgctgcccgt gatcacggtg gccgcgatcc aggggcacgc gttcgccgcc
     9541 ggcgcgatgt tgtccctggc gcacgacttc cgcgtgatgc gcgccgaccg cgggtactgg
     9601 tgcctgcccg aggccgagat cggcatcccg ttcacgccgg gcatgtccgc gttgatccag
     9661 tcccggctga ccccccggac cgcccacgag gccatgacga ccgcccgccg ctacggcggc
     9721 gtcgccgcgc tcgacgccgg catcgtcgac cacgcggtgg acgaggacgc ggtccggtcg
     9781 accgcggcgg ggatcgcctc ggcgcaagcg gccaaggccg gtccgaccct cggcgccatc
     9841 aaggcgcgca tgtacgcgtc cactgtggac cgcctgcgcg acgaggacga cccgctcggc
     9901 tgagcggacc ggggagtggc ctccgacccg ggggtcgaca tcggaggcca ctccgggcag
     9961 cacccgaccg cggcggcgac gcggtcgtgc tgcggcgggg tgacaccgcg gcgcggcggg
    10021 tggaccggcg cgtcaccgtg actcgtgggc ctccagggcg agctgcctca gctcggccgt
    10081 gcacatcatg aaccggtcgg tcggcaggtg cttgaagtag tagcccacgt ccgcccccag
    10141 agcgaacacg tggaccggca cccccgcccg cctgcccgcc tccacggact ggcgcagccc
    10201 ggacatgacc gccgggtgcc gcgtctggta cgaggaggcg acccggtggt tgccccggtc
    10261 cgcggcgagg tagaactgcg tcaggtcctt ggtgcccatg aagatctcgc tcgcgccggc
    10321 ttcgcagaac tccgtcaccg agtggacggc ggcgggggtt tccacgaaga ccgacagcgg
    10381 cacgtcgtcg ggcagctcga gccgctcccg caggcgcagg aactcgtcct ggtcgttgat
    10441 gaacggcacc gcgaagttca gccggtcgaa gtccggaccg aggtgctccc gcacgtgggc
    10501 gcgcaaagcc cggaacgcgt gcgggtagtt cggctcgtgc agcagccagc gcgcgccgtg
    10561 caggccgagt tccggattcg actcgtggtc gacgtcgacg tcgttggtga tctgcgcggc
    10621 gtcgtccgac cggaggtcca gcagcctcat cacgaggcgt tgcccgggga cgagctggtc
    10681 gacgatggcg cacagctccg cgccgatggc cgcgccgtag cgctcggcct cgggaattcc
    10741 cgcgcgcagc gcgtcgaggg ggctgagccc cgacgagagg cagacgaact cctcgcggat
    10801 gaagaacgag gtcacctggt cgacgcgggg ttggatcgcg ttcgtcgact ggatgtcggt
    10861 cgcgtcggcg atcacgacgc agaccgagcg gaggtcgtcg ggggtgacgg tggggtattc
    10921 gacggagttc accgagactt cggattcgcc gagggtgacc gattcgcggt cggtccgcac
    10981 ggtcacctcc ccgaccagcc cgacgagttc ggcgtgggga atccgcagca ccgggattcc
    11041 ccgcgaccgg cacagggatt ccatgtgacc ggtgcggcca ccgccggagc agaccacggc
    11101 ggccgacctg acgatggtgt cgtagagctc ggggccgagc gcttcgacca ccagcacgga
    11161 accgggcagc ggtcttccgg tgtggttggc gatgccgcga acactcgtcg acggcgaacc
    11221 gacgagcaaa accccgggga tctcgcgcgg gctcacggca tcctcctacc gattccgacc
    11281 ggtgtgcgga cctggcgtgg gagtcggcct gaccgccgac ccgcggggcc gacgtcgtcg
    11341 tgcacgacat cggccccggg tttgtgtgga acacgacgag gcatggcacg agcctcgcag
    11401 tcggccggcc ggcgccgcat cttctcgagt gcgaggtcgt ggtccattcg tgcgacaccg
    11461 ccttcggccg acgggcaacg gcgaagtagt cgggtggtcg ggaaccgtgc ggaaatggtc
    11521 gatagatgag cggagttcgg ttcaggcgac cggctccacc gcctcttcga ggcccagcag
    11581 gaaacggagt tcgcgcgggg tcacggagag gtcggtcagc ttcgtggtgg cggccgagct
    11641 caccgcgaac cgcaaggcgc gatcactcgg cggtgacgcg ccgccgcgcg cggcgagttc
    11701 gcgcagccgc tggatgttcc cctcgagccg ggccgcgagc gactggcgtt cgtcgtggtg
    11761 gcgcgcggcc atccggcgga cgtcgagcat gaccgagtgc tcgacgagtt cgcgcgattc
    11821 gggatcggcg gcgtcggcca ccgttccggc gatctcgccg cccgacacgt cgtaacacga
    11881 ttcgaggcgg tgcagcgtgg tggccgcgac ttccacggag tggttcttga tggcggccag
    11941 gttgaacgtg aacgcgccgg tccggccgtt gcggacgatc tcgtcgccct cccgggggct
    12001 gcccacgacg gacacgggac cggacggcgt gccgtcgggc ccgaggagcc ggccgtaggg
    12061 gtcgacctcg acgccgcgcc cggtgcgccg gtgcggcacg gcgatctcct tgcgcagcag
    12121 gttcgaccac agcgtcgaat cggcgcgctc gtagttcgtc tcgcgcccga agttcgacac
    12181 cacgagatcc gcttcgatcg tccgcgtcga atcccggtcc gcgacggaca gcaccaacgt
    12241 gcccgttccg gtggcccgga tgtgctgcac gcgaccggtg gtgagcgcga tctgcttgtc
    12301 ctcgcccatc gccgcgtcga cgatgtccgt ggtgtacgac atggcactca cccgcagcac
    12361 ggccaaaagc gtcccgtaac cgtccagcag tgcccgaagc tcgtccgtgg gaatccgctc
    12421 cagaatcgcg ggcaggtacg gctcccacga tttcgcgacc cgttccgtca ccaccaccgg
    12481 agatatctcg ggatgctcgc gggtgaggac ggcacaggcc cggtcccatt cttcgcggaa
    12541 tcggcggacg aattcctcgc ggccttcgta gtggtcgccg agcaattgcg gagcgggtag
    12601 ttcgagcact tggtgccggt ggtccggcgg ataggtgcgg ggcgtcagcc cggaaccgga
    12661 gatcatgtag atccggcctt cgtggccccg gcgcaacaac agcgtcgccg agtcgtacgc
    12721 gctgagcagc gtgccgacga tggcgacgac gccgtccttc cgcacgccga gcagccgctc
    12781 gatgccgctc ttggagtacg ggctgcgcac gaacgacggg tgctccagca cctcggccgc
    12841 gaacgccggg tacttcgtct ccagcccggt ggcgagcacg acgtggtcgg cctcgatcac
    12901 cgcgtgcccg tcctcgccgc cgccgagcgg ctcgaccagg tgctccacca cgacgtgcgc
    12961 gtggtcgtcg aagacctcca cgtcgaccac ctccccgtcg acctcgacca gccgcacgcc
    13021 cgtcgccgcc tcgcggacgg cctcggcgag gcggttctcc aggtagtcct ggtagatccg
    13081 gcgcggcgcg gggccggact cggtgaactc gaagtcgcgc cagtccgccg gccagtccga
    13141 ccggtcggcc tcgtggttgg cccagcggat gaagtcgtcg acgtcctcgc ggaatgccga
    13201 catgcggccc gcctggatgt tgaacacgtg gtgccagtgg ttgctctcgc gctggtacgc
    13261 caccccggag ctccggtatt ccggacgacg ttccaccaac accacctcta aaggctcgcg
    13321 ggcgaagcgg agaaagcgga tggtggtcgc ggtgccggcc agacccgcgc cgacgacgac
    13381 taccctgcga aaccggccga agcttttcac catgccacct ctgtcccctc tggcgctacc
    13441 cgccgaagcc cgggacggag tggccgaagc cgcaccgccc cgcaccgcgc attgggtgat
    13501 cgggcagtag aatacctgcc atcctgcgag gtggacatgc cgcgagaccc aatcgttcct
    13561 cggatttcac gtcggcgccg gccgaccgtt cgacacgacc gcaccggcga tcaccgcagg
    13621 tcaccgcgcc acgaccggaa cgggtcggca cggcggattt ccgcacattc ccgaagcttt
    13681 ttccggccgc gtgcttgact tttcttcgaa cgactccccg gaaaacgccg gaggccgtcg
    13741 acggcgcgtc gacggcctct cgcggcggat ggggaggggc ccggcgtcag gttccgcccg
    13801 accgcggcgc ggcggccggg aggagcgctt cggccaggcc ccgtccccgc ttggcggggc
    13861 cgtccggacc gaacgactga cccgacgcgt gcaggccttc gaagaccagc accaggtggt
    13921 cggacagcgc gtccgggtcc tcgaccccga gcttgcccgt cagctcccgg aaccgcgccc
    13981 tggtccacga cttcgccgcg agggcgttgc ggtgcgcggg cagcccgggt tccgggaact
    14041 cggccatcga catgaggaac ttgcagccgc ggaacgtcgc ggaggacacc tcggcgaaca
    14101 tgaggtcgaa caccgccagg atctggtcgc gcgggtcggg gcccgcctcc tcgaccgcgg
    14161 cggtgaaccg gtcgcggagc tccaggtcgg cgagctcgac gtaggcgccg acgaggtcgt
    14221 ccttcgacgc gaacaagcgg tagagggtgg tgggcgcgac gccggcctcg gcggcgacga
    14281 ggtcgacgcc cgtggcgcgg atccccctct ggtagaacag gtccccggcc actcgcagta
    14341 cgtgggaccg ggtctcagca gcggatcggt gcacggttcc ccttgccgtc tgccacgcta
    14401 gggatggttc cctccaggct actcgggtcc cggtggcacc accatcggcc gcgagggccg
    14461 accgcccgcg gcgtccggcg cggcggaccg ggctcacgcc gcgtcgccgc ccgcgagcca
    14521 cgtcgcgcac cgggacgcct cgaccgcgaa cggcaggcgc accaccgcga ccggcggacc
    14581 ggcgaggtcg gccgcgtcca gcaccagcac ctcgtcaccc gcgacgacca ccacccagcc
    14641 ctggccctcg tcctcgccgc tcggcacgaa caccggctgg ccgggcgtga cgccgagctc
    14701 gcggcgccac gtgcagccca gcgccacgtc gtggcggacg accgcggcgc ccgccgtgcc
    14761 gaacacgaag cggtgacggc ggcccgcgag gcgctcgtcg acgacgccga cgtccatcgc
    14821 cggcagctcg acccggcgca cgccgccggt ggcgaggtcc agcgtgtggc ggcgcagcac
    14881 gcccggcgcc cacacggcgt ccacgaccac gcggccgagg tcctcgtagg cgttgaccag
    14941 ggacagcacc tcgccctcgg ccacctcgaa ccagagcggg cggccgtagg cgagcaggcc
    15001 gatgcgcgtg gggccggtgg ccgggccgga gtacgggtcg cgcaggccga cgaggtcggc
    15061 ggcgcggctg tagtacggcg ccgagtcgaa gacgaccacg aaccggtccg tcacgccgac
    15121 cgcgcgcatc cggggcgcgc cgtccagcgg gaagggctcc gcgcgcagca cctcgccgtc
    15181 gaggccgagc gtgacgtgct cggcgtagcc gaggtccggg tgcgacatgg ccgtgtgcca
    15241 cacctggccg tcgaagacgg ggcgggccat cgtggcgccc gagggccagt cggccggcgc
    15301 gagggccgcc ggcctgggcc cgcggtacca ccgcgcgccg tccggcccca gccggacacc
    15361 cgacacgccg tacttgccgg accagacgag cgcaccgtcc agctcggcgg gcagcgcacc
    15421 ccgcaccacc agcgcttccg cgacttcccg taccgacgcg accacgccca ccaccccgtc
    15481 cacgcgttcc ataacactgt cttactacta tttatagcgg cgttatggaa cctcgtcaag
    15541 acgatccggc cctcggcgac gggtataccc ggatggcgta ttgcgccccc gttcggcggc
    15601 tcgccggaca gcccccgccg ggccgtcacg ggtggtcctc cggctccggc gcgaccgcgg
    15661 cggcctcgat cccgagcggc gcggcgcgac cggccgcgag cgggcggcgc cgggtgaggt
    15721 cgtggtcgag ctgccgggcc aggcgcggga tggtggtgga ggtcaggtag ccgtccgcgc
    15781 cggcgtcgag catgcggcgg accgggccgt ggaagctgac cgcgaggcgg tcgtcctcga
    15841 cctcggcgac gatgacgcgg gcctgcggga acatcgaccg gagcagcccg atcagctgcg
    15901 ggctgcccgg cggcaccagc agcacgtccg ccgtcttcgg cgccgcgtgc aggtcgagca
    15961 cgatgtagtc cccgcccagc gccgccgaca gcgccgccct ggccgaccgg gacagcttca
    16021 tcgcggtggc gaccacggtc acgtcgcgca ccgacggctc gcgatcgcgg tccacgtgcc
    16081 gcgcgcccgt gccggtgacc gtcgcgatcg gcgcgccctc gcgcgtgacg accaggctct
    16141 cgccgggccg gagggcgtcg aggagcgcga ccacgtcctc gggcaggcgg gtcacgtcga
    16201 ggtgtcgtgc accgggctcg gcgcggtcgt cggtcatgca ctacgggacg ggtgtgaccc
    16261 ctgcggcgtt gtccggcggg cgccgcggac ccgccgcgcc ccgcgcggcc gaaccgggcc
    16321 cggacgcggc aacggcacct cgctgtggga cgaggtgccg ttgtggaggt gccgcggggc
    16381 tacagcggca cgttgccgtg cttgcgcgcg ggcgtcgggc gccgcttgtc gcgcagcatc
    16441 gccagtcccc gggcgaccgc ggaccgggtg tgggacgggt cgatcacgtc gtccacgagg
    16501 ccccgctcgg ccgcgtagta cgggtgcacg agctgttccg agtactccgc gagcagctcg
    16561 gcccgcagcg cgtccgggtc ggccgacgcg gcgagctcct tgcggaagat gacgttcacc
    16621 gcgccctccg cgcccatcac cgcgatctcg ttggtgggcc aggccagcgc caggtccgtc
    16681 ccgatggacc gggagtccat cacgatgtac gcgccgccgt aggccttgcg cacgatgacc
    16741 tggatgcgcg gcacggacgc ctcgcagtag gcgtagagca gcttcgcccc gtgccggatc
    16801 acgcccgcgt gctcctgcgc cgtgcccggg aggaagcccg gcacgtccac gagggacacg
    16861 agcgggatgc cgaacgcgtc gcagaaccgc acgaaccgcg ccgccttctg ggacgcctcg
    16921 atgtccagca cgcccgcgaa caccaggggc tggttgccga ccagccccac gaccgcgccg
    16981 tcgatccggc cgaacgcgac caccacgttg cgcgcccacc cctcgtgcac ctcgaggaac
    17041 tcgccgtcgt cgaccaactc ctcgatcagg gtgcgcatgt cgtagggctt gttcggctcg
    17101 acgggcacga tcgaggcgaa ctccggccgc acgtcgtcca ccgcgccgac gggctcgaag
    17161 gcgggcgggg actccaggtt gttcgacggc agcatcgaca ccaggtagcg gacgtcctcc
    17221 aggcacgact cctcgtcgtc gtgcacgaac gacgccacgc ccgacagctc gccgtgcacc
    17281 gacgcgccgc ccagctcgtc gtgcgtgacc ttctcccccg acacggcctg caccacgtcg
    17341 ggaccggtca ggtacatctg cgccgtgccg cgcaccatga acgtgaagtc ggccagcgcg
    17401 ggcgagtacg cggcgccgcc cgcggacggc cccagcacca ccgcgatctg cgggatgacg
    17461 ccggacgcct cgacctggcg gcggaagatg ccgccgtagc cgtccagcgc catcacgcct
    17521 tcctggatgc gcgcgccgcc gctgtcgttc agcgcgatga tgggcgagcc ggtgtcgatg
    17581 gccatgtcca tcaccttgtg gatcttcgcc gcgtgcgcct ggccgagcga gccgccgaag
    17641 atggtgaagt cctgcgcgta gacgaacacg cgccggccgt cgatggtgcc cgagcccgcc
    17701 accacgccgt cggtgtgggg gcggtgctcg gacaccttca ggccgtgcgc ctggtgccgc
    17761 cggtagagct cgatctcggt gaacgagccc ttgtccagca gcatgtccag gcgctcgcgc
    17821 gccgtgtgct tgccgagcga gcgctgccgg cgcaccgcct cggcgttgga caccgcgcgg
    17881 tcgcgcaggt cgtcgttgcg ctcccgcagc aggtccatcg tgcggacggg cagctcgggc
    17941 cggaagtccg agtgctcgct gacgtggtcg atccctgaag tggtcatcgg cgtcctgcct
    18001 ggcgatcggt caccgcaccg gtgtcggcga gccaccgcac ggcgtcggtg accgtgtcgg
    18061 cgaacgggcg gggtttgagg tcgaacgtgc tcgcggccgg gtcgacccgg accgccgcgc
    18121 cgaccgtggc gatggccccg tactcggcgg ggatgtgcca cggccagaac ggctgcacca
    18181 ggtcgacgag ccgcccgacg ggcgtcatca tcgccgcggg caggaagacc gcgggcaacg
    18241 cgcgcccggt ggcctcccgg acaccggcca ggtactcctt catgtccagg tagtgcccgg
    18301 ggccgaagtg ccggccgacg gggcccgggg ccgcgtccgg ggacagcagc gccgcgtgca
    18361 gcgccgccgt gtcccgcacg tcgccgatct gcaacccgcc cgcgggccac atcggcatga
    18421 tcccgcgcac cgtgttgcgc aaccggtcga tctggtcgcc gagcttgggg tcgtggggcc
    18481 cgaggagggc cggcgggtag ctgatgacca ccggcgcccc ctcgtcctgg tgccgtctcg
    18541 cgatggcctc cgacgcggcc ttggtcgccg cgtacggctc ccgggtcgtg ccgacgggcg
    18601 actgctcgcg gatcacccgc acaccgggcg tgaacagcgc cgcgatgctc gacacgtgga
    18661 cgacgcggcc cgcgccggca cggcgggcgg cggagagcac cacctccgtg ccgtgcgcgt
    18721 tggtccgcag catctccgcc cgcctgcgcc ggtcgaacga gtacaccgac gccgcgtgga
    18781 ccaccgcgtc cgcgccccgc accgccgcgg cgaccgattg ctcgtcggtc acgtccccga
    18841 cgacgacgtc caccgcgtcg ggcggcacct ccaacggtcg cgtggcggct tccaccgcgc
    18901 ccgcgtcccg gaccagcagg cggacccggt ggccggcgcg cacgagctcc gccaccgtgt
    18961 gcgagccgac gaaaccggta cctccggtga cggtcaccag catgtgcact ccttcccgaa
    19021 gcgtgcggac ccggaggtca gacctggtgg aacgagctgc cgtagaacag cagcgccgac
    19081 gcgtccgcgc cgcgactgga cctcagcacc tgaccgacga agatcgtgtg gtccccgccg
    19141 tcgtagaact gcaccagctc gcactccagc caggccagcg aaccgttcag cagcggcgcg
    19201 ccgctgtgcg gtccctcgat ccagtcgacc gcgtcgaact gctccggccc gagcggccgg
    19261 cgcttgtcgg cgaagtactt cgcggtgtcc cgctggtcgg cgcccatgat cgacacgccg
    19321 aaccgcttgg tgttggcgat ggcgtcgtgc atgaccgccg agtgggcgat gcaggccagc
    19381 acgagcggcg ggtcgagcga caccgaggtg aacgcgttcg ccgtcatgcc gtgggcgtgc
    19441 tcgccgccga cggtcagcac cgtgaccccg gtcgcgaaca gggacatcgc gtcccgcagc
    19501 gtggtctcct ccatcgtggg cgccgactcg tacatgtccc tcatcccccc agcccggcgc
    19561 gggcgagcac cggggcctcg gcgtagggcg cgagcgcctt ccgcaggtct tcgggcaccc
    19621 gggagggcac cgtgttggtg ttcgggccgc gcatgcacgc gatccgctgc cgtcccttgg
    19681 cgaccaggac ctcctggccg gcggtgacct tgacgtagtc gaagctgaac tggatctgcg
    19741 tctgggtcag ctcctccagc cgcatccgca ccgacaggtc gtcgaagagg gtgatctcgg
    19801 agaagaactc gcactccacc ttgagggtga acagcttgag gtcgtcctgg aggtccttca
    19861 gcacgctcgg cgccttctcc ttcaggaaca tctcccggca ccgcccctgc caccgcaggt
    19921 agttcacgta gtacacgttg ccgacgaggt tggtctcctc gaagccgacc gtgtggcgga
    19981 tctcgtagta gtcggtcatg tcagccctcc ttgcccacga gcaccgcgaa caccaccggc
    20041 tcggcccggt cgacgacggt ggtcacccag gtggcgacct tggcgtcgcc ggtcgacagc
    20101 acggcccagc cgtccgggtg gacccggtcg acggtcagcg cctgcgtggt ggaaccggtc
    20161 ttgcgcaggc actccagggc actccacacg cgggtgccgg cgatggccgc cgtctcgccc
    20221 acctcggagg cgagcaggtc gcgcacggcg atcaggtcgt cgccgagcag ccccgcccag
    20281 tcctcttcgg accggccgac ggcctcctcg acgtccacgc cgagcgtgcc gcccggcgcc
    20341 gccgcggcga acgtgacgcc cgcgctgtgc gaagcggaca cctcggcccc gtcgacctcg
    20401 ggcttgccgt cggggcggta gcgcacctcg acggggcggt ccagcgcccg gctgagcgcg
    20461 agcgcggtct gcgcccggtg ctccggcgag gtgtcggtcg ggtcgggctc gaccacgatc
    20521 gcgcggctgc cgcccaggac ccgctccagc gagcgctcca ggtaggagcc gagcatggtc
    20581 ggcgtccacg gtcccgcgcc gtcgcgcttg cgcacggccc gcagcaccag gccctcccac
    20641 cgctcgacga gccggccctc ggggtcgcgc acgtcgaggt cgtaggtgta gctgtcgccg
    20701 tcctgcgacc gctcgcgggc gtccagcacc acgtactggg ccagctggtc gaccggcgcg
    20761 gccaggtaga gccgctccac gctctgcggc agcagcgtgg cgtcggggac gcagcactgg
    20821 atggcgtgca tcatcacgtc ccgcgtgccc gggtcggcca gcatccggtc ctgcggcagg
    20881 aacggggcga accaggtggc cacggacgtc gtggcgacct cggccaccgc gtgccgggcg
    20941 ctcgcccgcc ggtagccctg caaccgctgg aaccgcttgc cctggaacag gacgctgccg
    21001 tacagctcgg tgaccgggtc gaccggcacc agcggcagca cgggggcgcc gtcgaccacg
    21061 tcgccgggga tcgccggccg cgggaaccgc agccgggccc ggaagtggtc ggcggagaac
    21121 ccggtgtcct cggcccggat cgccacgtcc accgtctcgg cgtcgcgggc gagcgcggcg
    21181 atgcgcaccg tcagcgagcc ccccggccgc acgaccaccg gccgcaggaa ctccacgtcc
    21241 tccagcagcg gcggcgagtc gtgcccggtg agggcgctgg ccacctgggt catcgcctcc
    21301 atgccgatga ccgccgggaa cagcaggtcg ccttcgagga ggtggtcgcc caggtacggg
    21361 tcgctgccgt cggacaggtc ggcctcggtg accagctcca ccgccgggta gtggaccagg
    21421 acgcggtcca cgaacctggc cagcggcagc tcggtgcggg acatctccag cgtgggcagg
    21481 cccgccgcgc ggccggagac cacgagcacg gggcccgcgg tcgggtcggc cagcacctcg
    21541 cggagcaccg cgatgcccgc gtcggtggag atcggcgtga tgccgtcgcg catcagcgcc
    21601 tcgaccacgc ccagccgctc gcccatgccg gcgccggacc agacggacca ctccagcgcc
    21661 aggaccctgg cgccggggtg cttcacgccg aagtcgacgg tcagctcgct catccagtcg
    21721 ttggcggtcg agtagtgcgc ctcgccgcgc agtcccgccc ggccgatgat gctgccgaac
    21781 gtgaccagga gcttgatccg gtcctggtcc acggcgtcga gcaccgcggt gagaccggcg
    21841 atcttcggcg ccagcgtggc gtggaagtcc tgttcggaca gtccggtcag cgccttgggc
    21901 tcgttgcggc ccgcgccgtg cagcacggcg gtcacctcgc ccagctcggc gcggaacttg
    21961 gcgaccgcga cggcgatctg ctcggcggag gtcacgtcgg cccgctcgta gcggtgcttg
    22021 atgcccgccg cggtcatccg ggcgaggttg gccgccagct cggggtcggc ggccgggtcg
    22081 gcccgaccga tcagcgccag ggacgcgccc gagtcggtgg ccatcgcgat ggcgcactcg
    22141 gccgtgatgc ccttgccgcc gccggtcacc agcagcacgt cgtccgagtc gagcggactc
    22201 ccttccgcag gagtgggcgc cacccggccg gacaccgcgc gcagcaccgg cacggtccgc
    22261 acgccgtcgg cgtcgtaccg gacctgcgag aagccggtcg tggccgcgac ctcggccgcc
    22321 acccggcgca ccacgtcggc ctccgacccg gtcagcccgg gcgcgaggtc gaccagggtc
    22381 accgggatgt gcggcgcctc caggtgcagc gtgcgggcca ggcccgacgc gcccagcttg
    22441 tgctgcacga ccgcgagcct gcggccggac gccagcacgt cgtgcgcggc ctcgaggaac
    22501 aggccgacgt gcgcgtcgcc gccctccggc ggcagcagca ggagcacgcc gtcaccgggc
    22561 aggccggcct tcagcggctc ggccagcggg tggccttcgg gggcgtgcac ggtccactcc
    22621 cccaccgccc cgggtgtcgc cgcgacgagc tcgcgctcga cgtgctcgac caggaacggc
    22681 cgcacccacg gcgcgacgcc cggcacctcg ccgttgtcgc gctcgtcggt gtgcgccgtc
    22741 tcggccaggt tgtcgatcag gtcggccagc tcgcccatcc gcacggtggc gaagttggtc
    22801 gtgccctcca gggccgggcg gccgaggctg cgggtgacct cgttgaccag ctggccgacc
    22861 gtgatggagc tcaggtgcag gtcgtccagc gggtgggtgt ccgcggtgat ggcgtccagc
    22921 ggcagctcca cgcgctgcgc ggccaggcgg cgcagcagtt ccagcgtgga ctcgccgtcg
    22981 gagccggctg ccgtctcggg cttggccgcc ttggccgcgg cggaggcgtt ccgctcggcc
    23041 gagcgcaggc tcgagtccag cgcgggcgcc gtctcgcagg ggctcgccag gaacgtcatc
    23101 gtgccgtcca gcggcaggtc gcgcaggacc cggtcgctga acaggacctc ggtgcggacc
    23161 ggcgcgccga gcacgtgcgc ggcggcgacg acggtcagca gcgacgtgag cgagccgctg
    23221 tcggtgtcga cggagagcac gggcttgtcg ggcgcgatct cctccagcag gccggtgagg
    23281 acgcggccgg ggcccacctc gacgaccagg tcggtcacgg cggcggcctt ggcggcggcc
    23341 tcgtggaacc ggaccgggag ggtgatctgg tcgcgcagca gctcgcgcag gtcggcaccc
    23401 gcctccagca cctcgccggt gacggtggag tgcaccgggc ggatcagccg gccgaagtcg
    23461 aagtcgacca gccgctccgc catggccgcc gacgccggcg acaccagcgg cgagtggaac
    23521 gcgtgggaga cgttgatgcg ggtcgcctgc acgccctcgg cccgggccac cgcgcacacc
    23581 cggtccacgg cctcggccgg gccggacagc acggtctgcg cggggccgtt gtacccggcg
    23641 atgacgacgt cctcgccggc cgccagctcg agcgcccgct cgggcgtcgt gcccaggccg
    23701 gccatcgcgc cgccgccctt gccggcgctc gccatgacgc gaccgcgctc ggcggccagc
    23761 gacagcaccc ggttggcgct gagcgcgccg ccccagtgca gcgcggacag ctcgccgagg
    23821 ctgtgcccga cggccgtgtg cgcctcgatg cccagctccc gcagcacgtt cagcgcggcc
    23881 agcgagccgg cgacgatgcg cggctgcgcc acctcggtgg cgacctggtc gccgtcggtg
    23941 ggcaggccgg cggtccggaa gacctcctcg gcgaccggga agcggcggcg gatggcgccg
    24001 accgcgcccc gaccggagcc ctggcccggg aacaggaacg ccaggcgcgg cgccgtggtc
    24061 cggtcgtcca ggaacacgcc gtcgttggcg tcgaagagcg tggcgccctc gctcaccgcg
    24121 accatcagcc gctcgacctt gcgctcggcc tcctcgggcg tgcgggccac gacggcgccg
    24181 cgcagcgagg cgccgcccag ccgggccgac agcgccgccg ccaggtcgcc cagctcggcg
    24241 aacgccagct tcggcagcag ggcggcgacc tcggcgacgc ggtccttcag cgtcgtgcgg
    24301 tcgggcgcgt cgaacagcag cacctcggcg tcctggcgac cggcgaccag cgccttcgtg
    24361 cggacgtcga gctgctcgcg gcgcggcgcg tcgggcgagg cctccagggc gatgtgggtg
    24421 ttgatgccgc cgaagcccat ggccgacacg ccggcgcgca ccggctggtc gtccggccac
    24481 agctcggcct ccaccggcac gtacatcacc gcgtcgtcgg cggtcagctt cgggtgcggg
    24541 tcgtagtggc ccgtgcccgg cgggatgacc tggtggtgca cggcgagggc cgccttgatc
    24601 agtccggcga cccccgccgc ggccttggtg tgcccgaagt tgcccttgac ggtgctcagc
    24661 gcggcgggcc gggcgttcgg gtcggcggtg cggcgggccg aggacagcgc ctcgatctcc
    24721 gtctcgtcgc ccagcgccgt gccggtaccg tggccctcga agtaggacac cgactccagg
    24781 ccgtagcccg cgcggccgta ggcgcggtgc agggccaggc ggtggccgtc ggcctcgggg
    24841 cgggtgatgc cgcccttgcc gtccgacgag acgccccagc cggcgatggt cgcgtagatc
    24901 cgggcgccct tggccagggc gtcctcctcg cgcatcagca cgagcgagcc ggcgccctcg
    24961 cccggccaga agccgttgga gtccttgtcg tagaccttca tcacgcgctt ggccagcgcg
    25021 ccggtcttgg cgaagccgat gacctcgaac gggtcgatcg acaggtcgac accgcccgcg
    25081 atggcgacgt ccatgtcgcc ctcgacgagc gacttggcgg ccgtggcgac cgacagcaac
    25141 gacgaggagc acgcgccgtc gacggtgtag ccgccgccgc gcaggtcgaa gtagttgcag
    25201 atgcggccgg cgatggtgtt ggccagacca cccgccaggg tgtcctcgtt gatctccggg
    25261 aacggggcct tgtagtccac ttccagctgg ctgaggaagc ccgcgatctc gtcctcgggc
    25321 cagcccttgc cggtcagcgc cgcggcgacg gtgcgccgca cgtacggcca gcgcagccgc
    25381 atgacgttcg cccgggagaa ctcgccggtg aggctgttgc ccagcaccac tccggtcgtc
    25441 cgcttcggca ggccctcgcc gtcggggaaa cccgcgtcgg ccagcgcctg ggaggtcacg
    25501 tcgagcgcca gccagtgcgt caggtcggtg gagcggaacg tgctgcccgc gacgcggtag
    25561 cgaacgcggt cgaactcgaa gtcgcgcagc accgccgcct tcgtggtgta gaagcggtcc
    25621 ggtgcttcgg ggtcggggga gtagtagtcc gcctggttca tccgctcgtc gggcagcctg
    25681 cggaaggccc gacgaccggc caggacgttc tcccacagtt ccccggttga accggcatcg
    25741 gggtagcgca ggccgatgcc gacgattgcg atccgctcac tgctcatgct ttcaccgtct
    25801 ttgaggacat cgggggttct ggatggtccg agaaatctgc cgtgcacgga aagacaaaaa
    25861 cacccgtgac acttcgtaaa tgtgcgcaac gtaagactgc acgaccgccc gacgacactg
    25921 cttctccgat tttgccctgc tgacctgcgc ttttccataa cagcgtgatt tgaattccgc
    25981 gggtgaccgc cgggtcaccc gcgggcgccg cccggccgga cacccgcgcg gcccgccggc
    26041 ccggagacct gcggactcgg ctgatcgcgt cgccgtatgc cacccgacgt ggaccgttcg
    26101 gcccaccagg tgcgcacacc ggaagaagca cccaagacat aacgctggga tgctttgcgg
    26161 gccccgaaac gacgccgcga aggggcgcac atcggccgat cggcattgct ccggagaggg
    26221 aacacatggc gcgcaccgga accaacagac tcgtccggcg ggagcccgcg tcgacgaccg
    26281 tggccacgtc gtcgttcgtc aacggccact tcccgcgcag gcgcgggctc atcctcgtgc
    26341 tcagctcgat cgcgggcttc ctgctgaccg tggtgtggtc ggcgcagttc gtcgactcga
    26401 ccatcggtga cagcgtggcc aacaccctgc tcggccacga cgccaaggag accccgatcc
    26461 agggcatcgc ggcgggcatc gcgttcgcct tcgtcagcgg catcgcgggc accttcaccg
    26521 cgtgcaacat cgccgcgttc ggcgcggtcg cgccgatgct cggcgcctcc gggtcgcgct
    26581 ggtcgaagct ggccgcgacg ctcaagccgg tcgggtggct ggccgtcggc atgatcccgg
    26641 tgtccgccct ctacggggtg ctggtcggga tcgtcggcac gaggatgccc cagttcgcca
    26701 ccgcggcgaa ccagcccggc accctgagca gccgcagcat ccagtcgctg atcgtgttcg
    26761 gcgtcatcgg gctcgtcatg gtctacctgg ggctcgccgc gctcggctac gtgcgcgacc
    26821 cgttccgcaa gatcgccaag cggttcccga acgccccgat ggtgttcatg ggcgtgctga
    26881 tcgccgggtt cctcatcggt cgcccgttcg ggctgttccg gcagatgttc cgcgacgcgg
    26941 cggagagcca caaccccctg tacggcgccg cggcgttcac ccttcagtcg gtaggcaaca
    27001 tcgtcatcat ggccctactg ttcctcgcgc tggcgtactt caccggcggc cgtctgcagc
    27061 ggtggctctc cgcgaagccg agccggatcg ccgctgtgac ggcggccgcg ctgatcatcg
    27121 ccggtgtctt caccttcatg tactgggaca tcaggatgct ggcgcggcgg gagatcatcc
    27181 cgtggtaccc gaccgcgcct tgggcctgat cacgtcgagg ggaacaagca caccatgggc
    27241 ataccgaccg agccgatcgg cagcgtcccg cgtcccgcgg agctcctcaa gggcttccag
    27301 gaccacgcgg agggccgcat cgacgccgct gcgctgcgcg cgctgacgga ccaggcgttg
    27361 gcggacacgg tcagccggtt cgaggccacc ggttcgccgg tggtcaccga cggcgagcag
    27421 gacaagccga gcttcctgac ctacccggtg gcgggcatcc ccgacctggc ggcgggcggc
    27481 gcggtcgtgc cgttcgccga cggccacacc cgtgagctgc ccgtgctcac gagcgggccg
    27541 ttccgctact ccgcgcacgc cgtggacctg ctgcgcgccg cgcagcagct cacggcgctg
    27601 ccggtgaagc agccggtgat cgcgccgtcg gcgctggccc tgctctaccc ggccgacggg
    27661 atcgacggct actcgcgcga cgagttcgtc gcggacctcg tcaacgagac cgaggccgac
    27721 atccgcgcct gcctcgacgc gggggcggcc gtggtgcagc tggacttcac cgaggggcgg
    27781 ctgtcgctca agctcgaccc gtcgggcggg ctgctgcgcg acttcgtggc gctcaacaac
    27841 gcggtgctgg accggttctc cgccgaggac cgggccagga tcggcctgca cacgtgcccc
    27901 ggcggcgacc aggactccac gcacagcgcg gacgtcgact acgccgacct gctgccggac
    27961 ctgttccgga tcaaggcggg ccggttctac gtgcagctgg ccagcgagcc cgaccgccgt
    28021 cgggtgctgg ggatcatcaa ggagcacctg cccgccgacg cgcgggtctt catcggcgtc
    28081 accgacccga tcgacccgcg ggtcgagacg gccgaggagg tgcgcgaccg cgtgctggag
    28141 gcggccgagt tcctccccgt cgaccggctg ggcacctgcg acgactgcgg tttcgccccg
    28201 ttcgccgacg acacctccac ctcgcgcgac acggcgttcg ccaagatcgc cgcgcgcgtc
    28261 gagggcacca ggctcgccga ggcggccctg gggatctgac ccgctgtcca ccgacgccgg
    28321 ggcggccgcg aattcgcggc cgccccggcg tcgtcgtgcc cgcgtcctct tgcgcgccga
    28381 caacgcggga acagcaacgt gcgagaagag gaaagccgac ccgtaacgct gtaatgcata
    28441 aatgcatttc ccttcgggcc cgcaaggcac ggagggagta ggcggcgcgt caccggcgcc
    28501 gagacgatcg caggcgggcg gcgtcgtgcc gcccggccga atcgcacgac gggggcgagg
    28561 atgaccaaga ccactggccg cctggtgcgg ctgcccggac tggtcctgcg ctgcgcgtgg
    28621 gtgggcgcca tcgtgttctg ctacggcctg ctcatcgccg ggtcggcggt cggcgcgcgg
    28681 ttccggcgct cgaaggacgg gcgcggcctg cgcgacggcg accggtgggt ccggatgctg
    28741 acccgcctcg ggccgtccta catcaagatc ggccaactgc tgagcacccg gcgcgacctg
    28801 ctgccggaag aggtgaccac cccgctgggc cggctcaccg acggcgcctc gcccccgcgc
    28861 aggcggcgga tcgagcgcgc cgtccggcac gcctaccgcg accggccgtg gccgttccgg
    28921 gagttcgact gggaaccggt cgcctccggc agcatcgcga cggtccacga agccgtgacg
    28981 ctggacggca ggcacgtcgc ggtcaaggtg cgccgtcccg gcatcgagcg cgtgatgtgg
    29041 caggacttca ccctgacctc ctcggcgatg agcctgatgg gcatgctgcc caagctgcgc
    29101 aagatgccgt tcaagctcat gcacgggcag gtcggcggcg cgatcctgcg gcagctcgac
    29161 ttcgcggccg aggcggcgtc gctgaccgcg ttgcgggcca acctggaggg cggctcccgc
    29221 accgtgacca tcccggcgcc gctgccggag ctgtgcacgc ccgagaccgt ggtcatggag
    29281 ttcatcagcg acctcaggcg gttcgagccg ggcgagctgg acctcgacac caggcgctcg
    29341 gtgcagcggg ccgtgctcgg cacggtctac gagatgctgt tcatcgacgg cttcgtgcac
    29401 tgcgacctgc accccggcaa cctgtacttc gacctcaacg ccgacctggt gatgctggac
    29461 gccggcttcg tcatccaact gcccgacccg gtgcgccggt cgttcgcgga cttcttcatc
    29521 aacatggcga tgggcgacgg ctggatgtgc gcccagatcg tcatcgagag cgccgccgag
    29581 atcgccgacg actgcgacct ggagggcttc cgcgccgcgc tcggcgagct ggtggcggag
    29641 acgtcgggcg cgaagtccgg cgacttcgac ctggccacct tcgccggccg gctgttcgac
    29701 ctgcaacgcc gcttcggcct gttccccgcg ccggagttcg ccttccccct gctctcgctg
    29761 ctggtcatcg agggcatgat caagggcttc gactccgacc tcgacttcca ggccgaggcc
    29821 atcccggtgc tgcgccgccg caacatccct cgtgacgccc catccgctgt tgaaaggtga
    29881 gtcgagcatg gacgcaacca cccacgtccg ggtcccgctg gtcgacgagg gtcaggccga
    29941 aggccgcctc gccgagctgt acgccgacat caagagcaac accaacctgc cgttcgtgcc
    30001 ggacatgttc cgcctgctgt ccacccggcc ggacctcctc gaaggggtgg tcgccggcta
    30061 caagggcatg ttcatcaccg gcatcatgcc ccggcagacg cgcgagctga tcgcggcgtg
    30121 gacgtcgaag gtcaaccagt gcccctactg cgtcggcacg cacaacttct tcttccaggc
    30181 cttcggcggc ccccaggaga ccgcgcaggc cgtggagtcc gccgagtccg tcgaggacct
    30241 gccggtggac gagaagcaca aggtcctgct gcgcctgctc accaagctca gcaaggaggc
    30301 gtacaagatc accgacgtcg actggaagct ggccaccgac gccggctgga cgtcggagga
    30361 gctgctggag ggcttcttca tcgccggcat gttcaacttc atcacccgca tggtcgacgg
    30421 gctgggcctg ggcttctcgg tggcggcgag ccgggtgtcg cagcaggagg tcccgaccgg
    30481 aggcgacgcg tgacggcgtc ccgcgcggtc ctcatcaccg gcgtcaactc ctcgggcggg
    30541 ctctcctccg gcaccggccg cgccaccgcg ctgcgcctgc accgcgccgg ctggccggtg
    30601 tacgccaccg ggcgcgacct cgacgggctg aaggacctcg ccgaggaggg catcaccacg
    30661 ctccaggtgg acgtcaccga cgaggagtcg atggtggccg cggtggagcg gatcaccgag
    30721 gaccacggcg cggtcggggt cctggtgaac aacgccgcct acagcctcaa cggcacgatc
    30781 ggcgagacgc cgatcgacca ggtgcgccgg cagttcgaga cgaacttctt cgggctgtcc
    30841 cggatgacgc agctggtgct gcccggcatg cgcgagcagc gctccggccg gatcatcatg
    30901 atgtcgtcga tcttcggcct gttcgccacc cccggccgcg gctactacca ggcgaccaag
    30961 cacgccctgg aggccatcag cgactcgctg cggctggagg tgaagccgtg ggacatcaag
    31021 gtgtcgatca tcgagccgtc gccgatcctc ggctcgttcg tgccgaccac ggtcggcgac
    31081 ctcgggctgg acaccgacag cgacctgtac gccgacttct gggagcgctt cgtcgtctgg
    31141 cacggcgcct accgcgaggt cgacaagccc aagggccgcg gtcgcacggc ggtgcgctcc
    31201 ggcaaggtcg cggagaccat cgagaaggcc atcacggacc ccaacccgag gatccgctac
    31261 cggctcggcc tgccgaccca cctgctcaag ccgcagcgcg cgatcttcgg cgaccgggcc
    31321 tgggaggtgt tcgtcaccaa gttcttcccg cagccgtgac gactgcaccg cacgacggaa
    31381 gcggctccgg accttctcgg tccggagccg cttccgtcgt gggggtctca gccctcacgc
    31441 aaccaggccg ccatccgctc cccgatcatg atcgaggtca ggttggtgtt ggcgcgcacc
    31501 gtgctcggca tgatggacga gtcggcgacg tacagggact cggtgccgtg caccgcgccc
    31561 cgctcgtcca cgaccgagtc cgggtccgag gccggtccca tccggaccgt gccgaccggg
    31621 tggtaggcgc tgtccagact ggtcttcacg tactgccgca ccatgtcgtc gttgtcgatc
    31681 atggcgtccc gcagcaccac gaagccctgg ccgagcttca tgatgtccgg gtggtgcgcc
    31741 agcttccacg ccgtgcggac gccgtcgacg aggatgtcca tctcgcgctc gtcgtcgagg
    31801 aagttcagca cgatcgtcgg ctgggccgcg gggtcggcgg agggcagcgt gatccggccg
    31861 cgggaaccgg ggcgctgcga caccaccatc acgccgagga tctcggtggc gcccgccagc
    31921 atctgcaact ccgggaagtg cgccagcgag aagtggttga ccatgtagta ctggaggtcg
    31981 ttgaactcgc cggtcaccgg ggacgtggtg cgcaggatct gctggaggaa cgcctcggtc
    32041 gggtcgatca cccccggctg cggcaccagg aacgcgccgg tccgctggtg gtcgaccagg
    32101 ttgccgccga cgcccgacag gtccgcgcgg acgtcgatgc ccagccggcg caggtcctcg
    32161 gccgggccga tgccggagcg cagcaggatc atcggcgacg cgaccgcgcc gctggccagg
    32221 atgacccggc ggccctcgac gagctcgtag gagccgccct tcgccgccgc catgaccccg
    32281 atcgccttcg cgccgtcgaa caccacccgg tcgaccgacg tctcggccct gatctccagg
    32341 ttcggccgct gccggatcaa ccgcaggtac gtcgtgccgg tggtggcccg gtgcaccggg
    32401 tcgtgccggg tggacgggat cgagccgaca ccggtcgcgt cggggtggtt gtggtccttg
    32461 acctccggga aacccgccgc caggcaggcc tcgacgaacg ccgtctgccc cggcgacagc
    32521 tcctccggcc gccaccggcg gatcggcatc ggcccgccgc cgccgtggaa ctcgctgtcg
    32581 ccgaagtcgt agtcgttctc cagcttgcgg aagtacggca gcacctcctc gtaggaccac
    32641 ccggggttcc cggcggcggc ccagtcgtcg tagtcctccg cgacaccgcg cagacccacc
    32701 gtcgcgccga ccgccgacga gccgccggcg agcttgccgc gggggaagcg gatccggcga
    32761 ccgtcgtgga cgtccgcccg gaaggtccag tcattgccgt cgaacgacat ggcgcggccg
    32821 tagaagatct cctccggcag atcctccggc tcgacgtagt ccgggccgcc ctccaggagc
    32881 agcacgcgtc gcgcgggatc ctcggtcagc cgggccgcga gcgccgcacc ggccgacccg
    32941 gcgccgacga tgatgtcgtc atattgagcc gtcatgagca gtcctcgaaa gattgggcgc
    33001 ttcgggcgca gggttctgcg acccgcccgc cgagcctcgc accggccgcg atgaccttgc
    33061 tactcgcgcg ttgcccggcg tgcgcgccgc cgtcgacccc gtccgaccga gtagaggaac
    33121 actcggtttc accggtcgaa aagcgcccga gaatgcgtct cgcaccggaa atgccgcacc
    33181 ggccgccgcc ttctccgatc atgccgactt cgctggccac ggtgcccgcg gaggggctcg
    33241 gcgggcacgc tgggagtagg catccgggcg cggttgcgcc gaccatttca accaagtccg
    33301 aaacgccgcg gccacccgtg gcgggacgaa gggagcgaac attgtccagc tcttggggcg
    33361 cgctcaggcg tcgcatcctg actcccaaca tctcggcgac gaaactgtcg gtgcgcggct
    33421 tccactacaa ggacgagacc gcgcgggaac tgctggaaac ggtcggccgg tccttcctgg
    33481 agggctacgg ctacgccgcc gagtcgcgtg agccgctcga ggccgagcag aagctcgaga
    33541 agatgccgta caagttccgc ggcttcgcct acgagggcgc cgggatgggc ttcgcggtgc
    33601 gcgacgcgct cccgttcggc cggggcgggc ggaccgggcg gttcctccag gggcgggcca
    33661 ggaaccacga ctacatggtc ctcgtcggcg tcggctgggc gatggcccgg gtgccgaggt
    33721 cgcgctggtc caagctcggg ttggacgacc cgctgctgcg ctggctcgcg ctcgacggct
    33781 acggcttcca ccaggcgtac ttccacaccg agaagtacgt gcgcgagcag taccgcgagc
    33841 cggccttccc gtggccgacc gacggctcca gctggtactc gccgcgcggc atcgaccagg
    33901 gcatcggccg ggcgctgtgg ttcgtcggcg gcgccgagcc gaaggtcgtg gccgacctga
    33961 tcgagtcgtt cgccgaggag cgccacgccg acctgtacgc gggctcgggg ctggcggcca
    34021 cctacgcggg cggcctgccc gagagcgagc tgcgctggta cgccgaccgg gtcggcccct
    34081 acctgcccaa cgtcgcgcag ggcagcgcgt tcgccgccac cgcgcgggtg gaccagggcc
    34141 tcgtcgtcga ccacaccggt gtggcgacca aggtcttctg cgacatgacg cccgacgagg
    34201 cggcgaagct gtgccacgac acccggccgc cggcggtcgc cgaactgccc gagcagcccg
    34261 ggatcccggc cttcgaggtg tggcgcaggc gcatcaccgc gacgttcacg accgatgcgg
    34321 atgtgacgac atgacgacga ccgacacggc gggcgcgcga cgggccgtgc ccggaccgcc
    34381 gcgcagcgag acgctgagcc tgctggccag gatggcgcgg gaccggctct cggtgatgac
    34441 cggcgtgtcc cagcagtacg gcgacgcggt ccggctgcgg ctcggcccga agtcgatgta
    34501 cttcttcaac caccccgacc acgccaagta cgtgctcgcc gacaaccccg gcaacttcgt
    34561 caagggcatc ggcctggtgc acgcccgccg cgcgctcggc gacggcctgc tcaccagcga
    34621 gggcgagctg tggaaggcgc agcgcaagac gatccagccg gtcttccagg ccaagcggat
    34681 cgcgggcaag gccgacgtga tcgcgcagga ggccgcgggc ctggtcgcca agctgcgcgg
    34741 gcaccgcggc ggtcagccga tcgacatcag cgaggagatg accgggctga cgctcggcgt
    34801 gctcggccgc gccctgctcg acgccgacct cggcgcgttc gagtccatcg ggcactcgtt
    34861 cgaggcggtc cagaaccagg cgatgttcga gatgatgtcg ttgagcacgg tgccgcactg
    34921 ggtgccgctg cccatccagc ggcgcttcca ccgcgccagg gccgacctgg accgcatcgt
    34981 cgcccagctc gtcgaggagc gccgggcgaa cccgaccgcc gacggcgacg acatcctgtc
    35041 ccggctggtc gaggcgacca ggaacgaacc cgacccggtg gtcgcgcacc agcgggtgcg
    35101 cgacgagatg gtgacgctgc tgctggccgg gcacgagacc accgcgagca cgctcagctg
    35161 gacgttctac ctggccgaca agcaccccga ggtgtgggag cggatgcacg ccgaggccgt
    35221 cgaggtgctg ggcgaccggc agccgacgtt ccaggacatc ccccgcctga ggtacaccac
    35281 ccaggtgatc caggaggtca tgcggctcta cccgccggtg tggatcctgc cgcgggtgac
    35341 gcgcgaggag gacgtgatcg gcgggtacca cgtgccggcc ggcgcggacg tgctgctctg
    35401 cccgtacacc ctgcaccggc accccggttt ctgggacgag cccgacacgt tcgacccgga
    35461 ccggttctcg cccggccggt cgtccggccg gtcgcggtac gcctacatcc cgttcggcgc
    35521 cggcccgcgc gtgtgcgtgg gcagcggcct cgggatgatg gaggcgacga tcgtggccgc
    35581 cagcgtggtg cgcgagctgc gactgtccac tgtgcccggt tacgacgtgc gcggcgagcc
    35641 gatgctgacg ctgcgcgtgc gcggcgggct gccgatgacc gtgcggtcgg ccgcgtgagg
    35701 cgggagccgg cgccccggcc ggccggcgcc acgagccgcg gcgccgcgtc cacctgacac
    35761 ggagcccggc cgggaggcgg gaatcaccgg tgggtgcccg gagtgcgcgc gcagcgccgg
    35821 acggccgaac cgggtcgtgg caccttacca gcggcggaag tttcaattac gctgtgattc
    35881 ttctttctcc cgatccctga agcgccggcg gaggaaccga ttcccatgcg accaacactg
    35941 gtacaggccg gcttgcgcgg gctctccacc gcgcaggtgc ggcaggtgcg cgcagtgcgt
    36001 tacggcgcgg ccgagcagga cgtggcccgg gtctaccggg agctcgaacg cgacttcggc
    36061 gtgctcgcgc cgccgatcgc gctgcacgcg tcgtcacccg acgtgctggc ggcggcctgg
    36121 ttgatgctgc gcgagacgct gctcgtgccc ggcacggcgt cgagggcgca caaggaggcc
    36181 gtctccaccg ccgtctccga gaccaacaac tgcccgttct gcgtctcgat gcactcgtcg
    36241 atgctgatcg acctggtggg ctaccgcgac ggcgccatcc cggaccccgg gacccgtgcg
    36301 gtcgccgagt gggcgaccgc gaacgccacc ccggacgggg cggccgggca cccggtgccg
    36361 ttcccggcct cgcagggccc cgagatgatc ggcacggcgg tgatactgca gtacctcaac
    36421 cggatggtga acatcttcct cggcgagctg ccgctgccgc cgggggcgcc ggccgcgtcg
    36481 atgaccgtcg tgcgccgggt gctggtgtgg ctgatcaagt cggccgagcg gcgcggaccg
    36541 cggccgggcg cctcgttcga cctgctgccg gacgcgccgc tgccggagga catgaagtgg
    36601 gccgaggggc acgccgcgat cgccggcgcg tacgcgcgtg ccgcggccgc cgtcgacgag
    36661 gccggtcgcc ggtcggtgcc ggccgaggtg cgctcgctcg tgctggagca cctggcgcgc
    36721 tgggacggca agccgatggg cgtgagccgc gcgtgggtgg aggacgcgat cgccgggctg
    36781 ccggaggacc agcgggacgc cgggcgactg gccctgctga ccgcgttggc gtcctaccag
    36841 atcgaccagt cggtgctcga ccgcttccgc gcggggcggc cggacgacgg gtcgctgatc
    36901 gacctgacgt cgtggtcgag cctggccgcg gcgcggcgcg tgggcagctg gatgacgttc
    36961 cgcgcgcagg acgaagccct gccgccggcg gcgagctcga cgcacgagtg acgggagtcc
    37021 gccggcggct ccggcccgac accgggagcc gccggcgccg ccacgtccgg cgtccggcgg
    37081 catcgcgccg ggaaagcgtt gcggcaacgg ggatcgcggg cggcggtcag ctccggtgcc
    37141 gctcgtcggg cggggcggcc agcgccgagc cgaaccggtc gaccacgacc agcaggagca
    37201 cggcggccag cagacccgcg cccgcgccga tccacgcccc caccagccga cccacccgcc
    37261 agccgatcgc gccgcccgcc cccacgagca cgagcagcgc ggccaccgcg gccggcccga
    37321 ccacccactt ccacgagccg gcgcgacgca ccaggcacct ccggtcagcg ggcccgcgcg
    37381 tcgaggggcg tcgcgcggcc cagcggcgtc cgggcggccg gcacggccag gtcgacgtcc
    37441 ggcgcttcgc gggtgtccag ttcgggcagc gcgagcagga tcggcaggtc cagcgtggac
    37501 gccgacctgg tctcgatgtc cgcctccgcg gtccggcccg cccgcacgga gcccgcctcg
    37561 gcggcgccga cgaacaacgg ccgccgcttg gacgggttgg ggtcgaggtc gtcgaccgcg
    37621 accaccgcga cccggaggta gaaccggccc tccggcagcg cttcgagccg gtagggcccc
    37681 gagccgtcgc ggatgtcgca cgcgaccggg acgccctggg cgatcgggtc cttgaacgcg
    37741 ccgacgtaca cgcgcacggg cgtcgaggtc tccggcacgc cgacccaccc ggccaccgcg
    37801 cccgcctggg tgccgcgcgc cggtccggag aacgacgacg gcgacaggat gccgccgtag
    37861 gacagcgcgc ggtagcgggc gggcgggacg ccgacgctgc gggtgaagcg gctggtgaac
    37921 gtgccgaggc tgttgtagcc caccatgtac gagatctcgg tgacgctcaa cgacgtctcc
    37981 agcagcagct gcttggcctt ggtgagccgg atcgcggtga ggaaccggcc cggcgaggtg
    38041 ccggtcagcg tccggaacac ccgggagaag tagaacttgc tcaatatcgc ggtgtccgcc
    38101 atgtccgcca gggaaagcgg ctcgtggtac cggctccaca tcgtgtcgat cgcgcgctct
    38161 accgcagtct gcacaacggt tcctccattc cactcgctga agcggtcacg gtgagcaccc
    38221 gcgcgggccc gggggtccgt ccgaggatgc tccgccggtg tggcggggtc tactccgcgc
    38281 ttgcggtgcg gcgtcggcgg caacggcggc taccgccgac ccgtgccgac cgcgaccgcg
    38341 accggttcgg gcgtccgctc gcgcatccgg acgctgatcc gcaggtgctc ccccgggccg
    38401 gtggcgatca cgtggccgat cccgccggcg aactccaggc ccgaccccga caggcgcggg
    38461 ttgccggcgc gcagcgcgac cgcgacgcac cgggtggccg aggcgccgac gacgagctcg
    38521 tggtgcagcg ggccttcgac gagcgtgctc gacgcgaaca cgctgcacgg gatcaggtcg
    38581 tcgatgagac ccaccgtcac cttcgactcg tcgtcccccg cggggacctc cagcgtgccg
    38641 acgaccgagc cgctgccgcc gaagcggggc atcggcatcg cgtcgaacac cgacgagccg
    38701 gtctccagcg ggttgtcgaa gtcgggcagc gcgacggccg cgagcaggcc gctcaccgcc
    38761 gggttgcggt actgggtcgg cgagaggccc accgcccggg tgaacctggt ggtgaacgtg
    38821 cccacgctgc tgtacccgat cgtggcgacg atgtccgcga cgttcatcca cgtggtcagc
    38881 agcaggcgtt tcgcctcgaa cagccggacc gcggtcaggt atcggcccgg cggcacgccc
    38941 accgcggcgt ggaacaggcg ggagaaatga aatggactga ccagtgccgc gccggccaca
    39001 tcgcgcaggg tcagtggttc gtagtagtgc gtgcgcatca acgtgatggc gcgctgaacg
    39061 gcatcatgca cggtcgtttc cctttcggcc tgaatagcgg tcgaatgatt cgcggcacgg
    39121 cgccacgcgg ccggacgtgc gacgccccga cgtcgtgcgg tccgaggtag agccgctgcg
    39181 gcgcggcgcg aacctatcca ctcgctttat cgtgaatacg gcggttccta cacgatgtgc
    39241 cgatcttcac caccccagat ggcctttgcg cgaagccccc aataacttcg caacgggaag
    39301 gacgctagca ggcaggggtg gcgctggaaa ttgcccgaga accagaccgc aatatgtgag
    39361 aggaccctga cccgttccgc ccaaccggta cggccgggca ggcgcacccc ggttcacccg
    39421 accgccgagg cgggtcgccg gccgtcacga agggtgacaa tttactcacc ggctgtccga
    39481 gggacctgat ccgaccactc ggcggcccct ccgaggaccg ccccgacctc ggatccgagg
    39541 gccgaaccga gcagagctcg caggtcggaa gggctgtccg cgccgatccc gcaccgggca
    39601 cccacggtca ccgacctggg cgtcgccccc tcggcgcgtc gaccgaacgg ccggtgcgaa
    39661 ctcccccgtc atcgctaagt gtaacggtgt catgccatca ccgaccagcg ccgatccgaa
    39721 cccgtccgtc accggacgcc cagtcgagac ggtaaatgcc aatcgggccc gcataaggac
    39781 cggtgatcga tttcccggaa ttccacgcga ccgggttccc ggccattcca caccgatctc
    39841 cgcgatctcc ggagcgggcg tcggatcccc ggccgcggct gtccgcatcg ggatcccgca
    39901 ggtcgattcg acccgtcacc acccttcgcg gcctcgatgc gcgaccgcct cgcgggggtc
    39961 tccgagtcgc cgaccggcgc gatggccgtt cggctcaccg atcaattcgg ccattcgccg
    40021 taccgcgcgt ccgcgggcac gccccttgct tgatcgatcc gtctgcccta ctgttggccg
    40081 cagacgatag ggatggttcc cttacatcgg ttggcacccg attggaagac gacccgggaa
    40141 ggtgggcgac gagcgcacgc gcgagcgtcc accgatccgg aacgaccccg taccgcgtgg
    40201 cccgcttccc gacgtccgcg tcgccccgat cggcgcggtc gacggcccgg cgggcgccgc
    40261 gcccccgtcg ttgaccgccc gcgcggccct cgtcgtggcc gcgccggtgg ccggcccgcc
    40321 ccagcccacc ccggaaccgg caccccaggc cgactccgag gtggcgcccg cggtggtgga
    40381 ggagaagtcg gcgaaccgag tcgtctgctc caccacgggc gaggcagcgg caatcccccg
    40441 accgctgcct cgccccaccg cacccgccgc gcacgctccg gtgtggacga tcgccggcgc
    40501 ggtctccgcg ccgtgccagg tgtttccccg gaatcgacag gacgtcggtt cggcaagccg
    40561 aacgacccgg agggcgcggg gtccgacccc cggccgccgc gaacgcggtg cgtcaccacc
    40621 acggcgccgg cccggatcgg cggccggctc accgcgccgg cggtcccgac ccggcccgcg
    40681 gaccgaccca gccgcccagc gggccggcgc ggacccgtcg tccgatcccc ggcctcacgc
    40741 ccacgacgac ccggccgtgc caggcgatct gaagggcggc tccgacacgc cccgggaggt
    40801 acgctcgcca ggtccgcacc cccgaacggg gagcgcgtgt cacacgatcg gcgcaccata
    40861 gcataacatc gttacacaaa gaataacggt gttgtgcaac actgtcaagg tgagtcctcg
    40921 caagctggat ccggaaacgc gcgccaccct cgtggacatc gcggcgcgac tcctggccga
    40981 gcacggcgcc gaagcgctgt cgaccaggaa gatcgccgcc gaggccggca cgtcgaccat
    41041 ggccgtctac acgcacttcg gcagcatgag cggcctggtg cgggagatgg tgcacgaagg
    41101 cttcgcccgc ctggagcgcc agttctccat ggtggtgcgg accgacgacc cggtggcgga
    41161 catggccgtg ctcggctacg cctaccgcca gaacgccaag gcgaactccc acctgtacgc
    41221 ggtgatgttc ggcgggcagt cgctggccgg gttctccctc accgacgagg accgccagta
    41281 cggccggtac acgctgctga ccgtcgtgga gtgcgccacc cgctgcatcg aagccggccg
    41341 gttccgcgac ggggacccgc tgctggtcgc gcacgagatg tggatcgcga cccacggcct
    41401 ggtcaacctc gagctcggcg gctacctgat cgacccggtc gacgccgacc gctgctacga
    41461 cacgatcctg cacagcctgc tcctcggcgt cggcgacgac gcccaggcgg tggcggcctc
    41521 gatggccgcg tcgaagaagc gccgggccca cgaggtcgaa gccgacccgg cccccgcgga
    41581 accggccacc acccaccgct gaccccggcc gggacccacc cgggcccgcc cctcccccac
    41641 ctcgactccc cgtgcccgat ccggctgccc cgacaccggc cgccgcgttc cggcacgacg
    41701 cgagcgcggg ggccgggccg tgtcgcagcc ctgcccccgc gctcgcgaga gatgtccacc
    41761 cattccgggc accggtaccg gcaccggccc cggtccgcgg cccgctacgc cttgtaccgg
    41821 gtgccgttcc accagttgtc gttgggcccg tgcgagtcct cgacgtcgta ggtgtccttg
    41881 aagcgccacc agtcccaagg gtgctcgagc tggtcttcct gccgccccag gtgggtgatg
    41941 tccaggtagt tgtagaagct cttgaagatg tccccaccgc ggtcgaagat cgagtaggtg
    42001 aagaagacgt cctcgccgtc ccggtagaac gagctgacgc ccggcgactc gcccttgtcg
    42061 gtggagacct cgtagtcgta gttgaagtcg ctgccgaacg acgagtacca cgggatgttc
    42121 cagcccatgc gctccttgaa cggcgtgaag tccgccaccg gcgcccggga gatcatgacg
    42181 aacgtggtgt cgcgggccca catgtgcgag agctcgccga cgctgtccgc ctgcatggaa
    42241 cagccgatgc agccctccgt ggcgcccggg ctgaacatgt agtgccggac gatgagttgg
    42301 cggcggccct cgaacaggtc cagcagcgag agccggctgc cgcccggacc ctcgaaggtg
    42361 tacttcttct cgaccttcac catcggcaac cggcggcgct cctccgcgat catgtcgcgg
    42421 gcgcgcgtga cttccttctc cttttccaga agcgctttgc gcgcctccaa ccactcttgc
    42481 cgggagacaa ctttcaactg gctcatcggt tctcctcagg attgtcgggg gaacgactcc
    42541 accgatcccc ggcccggcgg atggcgagtg gtgccacctg cggcggccgg ggactatccc
    42601 tcgtcagaat atgtggattc cgcgcgacca aacttcttcg agattgacgt cttgacagca
    42661 cggattcgat ctgaacacgc tgcgtgacgc cggtgtcacg gagattgcga agatcggcgg
    42721 aggacggccc gacggcgtgc gcacgcccgg tgacgtgggc gtggggcggc ggcgggactg
    42781 tccagcatga gcgcccggcg ggcggcgcgc atccgcgttc gtgctcacct gcggcaagcc
    42841 ggaagaatcc gccggccggg ccgtcacgga caatgccgac gccgccgggg cacctgaata
    42901 tgatcgtcca aaagcgaccg ggatcgaccc ggcgggccgt cggtaaatgc gccggaagac
    42961 ctgtcgcgtc acccggacag cgcacgcggc aagtcgtcgg gtaagtcagt agctaaatgc
    43021 aacctccagg gtgcgccaag tcggccccgg gtaccgcaaa acaccacttg cgccgccctg
    43081 acctgcgaga acgaccacca ggggcgctca acacggacgt ccggagcggg ccgaagaccg
    43141 catcggcaaa tgctcctgca cgtgcaccgc ccggtgagca agcctgaagt agctaccctc
    43201 gtgaaccctc tgcaactctt ttcctcgttc gcttgtccgg tgacgggtcg cccgagctgg
    43261 ggggacgagg ttgagtgcac tgcgcgcctc gcggcgcaat tatcccgaga tcgtcgggcg
    43321 ccagtccgac accgatggcg cctatgcggt cgtgcgtgga cccgccggaa tgggattcgt
    43381 cgccggccgc ggcgggcagg cgcaccggtt cgcgaacaag aaccggctca ggaacgaaag
    43441 ccactcgcgg cccggcggca tcgggcggcc ggtggcccgg gtgcggtggc ccggaaatgg
    43501 gtcgcgggaa aagtttccct ttcccgcggc aggccgggac accggtcgtg gcacgtggtt
    43561 cgtcggcgag tccgacgccg agcgcgtcgc cgacctgatc gaccagtgcc cggagcgccg
    43621 ggacgaggcg ccgcggaccg cggcgccgac cggcgcaccg ggcacggcag ccccgttcac
    43681 cggggatgtg cgcgccgcgc cgccggtcgc cgacggcgcg gcgcccgtgt tcgagacgtg
    43741 gcggcgacgc atcgccgagc aagtcatcca ccaggaagga gtcagcttgt gacctccaca
    43801 gccagttggc tgcgcaggca actacccggc gtcttggcac tcgtgctcgt cgcggccacg
    43861 ttcttggtgg cccggctgcc ggaggtgtcg gccgaggagc ggcaggaagt cgcggcccag
    43921 ttcgggttcc agcccgagtc gatcgccctg cccggcggct acacgcagca gaccatccgc
    43981 caggtgaacc agcgctacca gcacatcaac gcctggatct cctcggtcgg ctcggcggtc
    44041 gcgatcaacg acctcgacgg cgacggcctc tccaacgacc tgtgcttcgt cgacgtgcgc
    44101 accgaccagg tgatcatcac gccggccccg gaggccggcc ggaccccgcg ctacgagccg
    44161 ttcgcgctgt cgcccggctc gctgccgatg aacgacgtga tggcgccgat gggctgcgtg
    44221 cccggcgatt acaacgagga cggccggatc gacctgctga tctacatgtg gggccgcacg
    44281 ccgatcctgc acctggccca ggccggcgcg acgggcatgg acgaggacac ctacgaggcg
    44341 accgagctgg tgcccggcaa gtcgtccggc acctacgacg gcccggagtg gaactcgaac
    44401 tccgcgaccg tcgcggactt cgacggtgac ggccacgccg acatcttcat cggcaactac
    44461 ttcccgcacg gcccggtgct ggacccgtcc aagaacacgg gcgtctggat gaacgactcg
    44521 atgtccgccg gcttcaacgg cggcgaggac tacatcttcc tgtcgaaggg cgcctcgggc
    44581 gacaccccga agtgggagat gtccgacccg ttcccgctgg aggtctcccg cggctgggcc
    44641 ctcgcgtcca gctccaccga cgtgaacggc gacctgctgc ccgagctgta cgtcggcaac
    44701 gacttcggcc cggaccgcct gctgtacaac atgtccacgc cgggcaacct gaagttcgag
    44761 gtggtcgagg gctcgaaggg cccgatggag ccgaagtcca agaacgtcgg catcgactcc
    44821 ttcaagggca tgggcgtcga cttcggcgac ctgaacggcg accaggtgtt cgacatgtac
    44881 gtcagcaaca tcaccgcgtc gttcggcatc gaggagtcgc acttcgcctt catgagccag
    44941 gagaacaacc tgagccgggt cacctccagc ctggaggacg gcgacgcgat ctgggaggac
    45001 gagagcgcgc cgctccagct ggcctggtcc gggtggggct gggacgtgaa gctgtccgac
    45061 ctcgacaaca acgccgagct ggaggtcctc caggccaccg gcttcgtgaa gggcgacgtg
    45121 aaccgctggc cccagctgca ggagttggcc acggccaacg acacgctgct ggacgacccg
    45181 atgtggtggc cgatcgtcgg ccccggtgac gacgtgggcg gcaaccacca cttccacttc
    45241 ttcgccaaga acaaggaagg cttctacagc gacctgtcgg gcgacctcgg catggccgcc
    45301 ccgatcccgt cgcgcggcat cgcgaccggt gacgtcgacg gcgacggcaa gctcgacatg
    45361 gccatctccc ggcaatggtc cgacccggtc ctcttccaca acgacggcgg ctccggcaac
    45421 ggcttcctcg ggctgcgcct gacgcacgac gagcagcaga ccgcgggcgc gttccccggc
    45481 gcgggctcgc cggtcatcgg cgcggaggtc acgatcacct cgtcgtccgg caagaagcag
    45541 atcaaccgcg tcgacggcgg cagcggccac tcgggcaagc gcagccacga ggtccacttc
    45601 ggactcggca ccgacaacgg gccggtccag gcgcacatca agtggcgcga ccgggacggc
    45661 gagatccacg agcaggacat gacactgaac ccgggttggc acgacatcca gctcggcgac
    45721 caggccaagg agaagtgacg gaaatggccg agaccaagac ggtggcggcg agcccaccac
    45781 ggcacga
//
