LOCUS       NZ_CP064192            23565 bp    DNA     circular CON 30-JAN-2024
DEFINITION  Saccharothrix sp. 6-C chromosome, complete genome.
ACCESSION   NZ_CP064192
VERSION     NZ_CP064192.1
KEYWORDS    RefSeq.
SOURCE      Saccharothrix sp. 6-C
  ORGANISM  Saccharothrix sp. 6-C
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharothrix.
REFERENCE   1  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Saccharothrix texasensis strain 6-C
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2020) College of Life Sciences, Chongqing
            University, University Town Road, Chongqing, Chongqing 401331, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 10:20:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,916
            Genes (coding)                    :: 7,819
            CDSs (with protein)               :: 7,819
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 41 of 97
            Pseudo Genes (incomplete)         :: 78 of 97
            Pseudo Genes (internal stop)      :: 6 of 97
            Pseudo Genes (multiple problems)  :: 27 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:34:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1070706
            Orig. end                         :: 1094271
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP064192.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23565
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23565
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23565
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13565](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13565)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    333..346
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            592..1104
                     /locus_tag="IOD16_RS05045"
                     /old_locus_tag="IOD16_05040"
     CDS             592..1104
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800235.1"
                     /locus_tag="IOD16_RS05045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05040"
                     /product="polyadenylate-specific 3'-exoribonuclease AS"
                     /protein_id="WP_123743428.1"
                     /transl_table=11
                     /translation="MRFFYDCEFIEDGVTIDLVSIGVVDEEGREFYAVSTEFDPAKAGP
                     WVRANVLNQLPSPADRAWRSRERIRADLLDFLGGPKANRDDIELWAWFAAYDHVALAQL
                     WGPMPALPRCLPRFTRDLRQRWEDVGKPHLPPAPADAHDALADARHNLARWKVIESERL
                     RKGFAVR"
     misc_feature    complement(608..626)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.92"
                     /tool="antismash"
     gene            1185..2210
                     /locus_tag="IOD16_RS05050"
                     /old_locus_tag="IOD16_05045"
     CDS             1185..2210
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004558616.1"
                     /locus_tag="IOD16_RS05050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05045"
                     /product="6-phosphofructokinase"
                     /protein_id="WP_123743427.1"
                     /transl_table=11
                     /translation="MRIGVLTGGGDCPGLNAVIRGVVRKGIEAHGWDIVGFRNGWQGPV
                     ENLTKPIGLDDVEDILTRGGTILGSSRTNPYKIDGGVDRIRETLAANQVDALIAIGGED
                     TLGVAKRLTDDGIGVVGVPKTIDNDLGATDYTFGFDTAVHIATEAIDRLRTTAESHHRA
                     LVVEVMGRHAGWIALHSGLAGGANVILVPERQFSVDKVVEWVERRFERQFAPIIVVAEG
                     AMPEGGAETLHSGEKDAFGHVRLGGIGTWLAEEIAERTGKESRAVVLGHVQRGGIPTAY
                     DRVLATRFGLHAVDAVADGDFGVMVALRGTDIVRVKLSEATEELKTVPLERYQEAEVFF
                     G"
     gene            complement(2324..2680)
                     /locus_tag="IOD16_RS05055"
                     /old_locus_tag="IOD16_05050"
     CDS             complement(2324..2680)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010242454.1"
                     /locus_tag="IOD16_RS05055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05050"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_201439104.1"
                     /transl_table=11
                     /translation="MSSVASKSLAEPEEVRDFPHGHVDLVTVGGTTVGRAEFQPGWRWS
                     QDVKPIAGTDSCQASHTGYILSGRMHVVMDDGSEGEAGAGEAIVVEPGHDAWIVGDEPC
                     VMVDFTGLHDYAEK"
     gene            complement(2703..2951)
                     /locus_tag="IOD16_RS05060"
                     /old_locus_tag="IOD16_05055"
     CDS             complement(2703..2951)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023174.4"
                     /locus_tag="IOD16_RS05060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05055"
                     /product="DUF4242 domain-containing protein"
                     /protein_id="WP_148088803.1"
                     /transl_table=11
                     /translation="MLFMDVHNHLPEGAGPGDVAEAHAADLRTQDRYGVQYLNYWVDEK
                     DGKVFCLVDAPDAETAHRVHREAHGLVADEIYPVVQG"
     gene            3053..4768
                     /locus_tag="IOD16_RS05065"
                     /old_locus_tag="IOD16_05060"
     CDS             3053..4768
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="IOD16_RS05065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05060"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_201439105.1"
                     /transl_table=11
                     /translation="MRATCQVRVLGGFAVAVDGRPVPGDVWRNRRAADVVKLLAVAPDH
                     RLHREQVMDRLWPDLPADAAGANLRKAVFYARRALGRADAVRCEGRLLTLWPGGDLDVD
                     LDRFQRAADAALASGDAERCALAAAGYRGGLLVDDRYECWVAEPHDKVEGRYAALLRAA
                     GDWERLLDLDETDEQAHRAVMRRHLAAGRRGEALRQFDRLRRTLRERIGVGPDAETVEL
                     YESALSLDAAEPPSPAQRAAVALANGLVAFGRRHLAEAERLARQARVLALDADLGHELG
                     EASTLLALVAHARGTWHRLFREEFADAVRHPSRPVVYDAHLCLQEFYLYGPEGHDGAES
                     FGRDLLDIASRAGSAAGRALAYLLLGEFALLSGRLDDAVTTLGESLVETERAGCGSARS
                     LALERRAEAEARRGDRAAARADLDEALPLARSSRIPSHLVIRVHGVRVLAAGTLGGALG
                     AIREAERWLTEAPHVCDPCSMGFRIAAATACANAGSPSRARPHLAEAERISGLWQGGPW
                     TAALWEVRAEVRRAQGQRTRATALFLEAAERFAAMRRPLEERRCRAAAASLSDR"
     gene            complement(4755..5774)
                     /locus_tag="IOD16_RS05070"
                     /old_locus_tag="IOD16_05065"
     CDS             complement(4755..5774)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022646.4"
                     /locus_tag="IOD16_RS05070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05065"
                     /product="DUF2891 domain-containing protein"
                     /protein_id="WP_201439106.1"
                     /transl_table=11
                     /translation="MSDTRLDDSTAARLLSTAVENVQRDYPAHWSHVVAGDADLVPQRV
                     LHPIFAGSFDWHSCVHQTWLAVRLLRVRPGVEGAAQARRVLESLITVGNAEVEAAFFDG
                     PSGGFWERPYGWAWLLVLDAELRAWDPPLAAALRPLSAVLRDRYLAKVTGARLPVRTGT
                     HGNTAFATGLVLDAARAVGDGELASACAEAALRWHREDVGYGGFEPDAADFLSPALTEA
                     DLMRRVLPADGFTAWFEAFLPHLDDSRWKVLREPVPVDDPGDPHGSHLVGLALSRAWQW
                     RAVADALPPGHRYADLARTAAEAHRETGLRLVSGHGYYAEHWLGTFAAYLDLGAFTGR"
     misc_feature    complement(5765..5779)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.0"
                     /tool="antismash"
     gene            5839..7227
                     /locus_tag="IOD16_RS05075"
                     /old_locus_tag="IOD16_05070"
     CDS             5839..7227
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800237.1"
                     /locus_tag="IOD16_RS05075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05070"
                     /product="3-deoxy-7-phosphoheptulonate synthase class II"
                     /protein_id="WP_123743425.1"
                     /transl_table=11
                     /translation="MNWTVDVPVDTLPELPPLPPELRDRLDDALSRPAAQQPEWPDAEQ
                     VRRVRAVLESVPPITVPAEIDRLRDNLAEVARGEAFLLQGGDCAETFADNTEPHIRANV
                     RTLLQMAVVLTYGASLPVVKIGRIAGQYAKPRSSGIDALGLPSYRGDIVNSLVATPEAR
                     VPDPSRMIRAYANAGAAMNLLRAMTTAGMADLHRLHDWNKDFVRQSPAGERYEALAGEI
                     DRGLRFMSACGVNDTSLHTTEIFASHEALLLDYERALLRLDTNGEQPRLYDLSSHFLWI
                     GERTRQLDGAHIAFAELLSNPIGLKIGPSTTPEMAVEYVERLDPHNQPGRLTLISRMGN
                     GKVRDVLGPIVEKVTASGHQVIWQCDPMHGNTHEASTGYKTRHFDRIVDEVQGFFEVHR
                     RLGTHPGGIHIELTGEDVTECLGGAQEISDLDLAGRYETACDPRLNTQQSLELAFLVAE
                     MLRS"
     gene            complement(7305..9374)
                     /locus_tag="IOD16_RS05080"
                     /old_locus_tag="IOD16_05075"
     CDS             complement(7305..9374)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419659.1"
                     /locus_tag="IOD16_RS05080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05075"
                     /product="PASTA domain-containing protein"
                     /protein_id="WP_201439107.1"
                     /sec_met_domain="Pkinase (E-value: 1.5e-45, bitscore:
                     154.5, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERSATNVIGGLLEQRYRVGALVARGGMSTVYRGVDTRLERTVAI
                     KVMDPRFSADPQFVARFEREARAAAKLHHPGVVQVHDQGVDEDRVYLVMELVEGGTLRD
                     LLTARGTLDVPLALTVIEKVLSPLAAAHRADLVHRDVKPENVLIGPGGTVKVADFGLVR
                     AVSTVGVTSDTMILGTVAYLSPEQVTTGTTDARSDVYSAGVLLYEMLTGAPPYVGDNAI
                     SVAYRHVNDDVPPVPGVPAEVAELVRRATRKEPFLRPADAESFLSEVETARAVLGIAAV
                     DVPVPSAAAPAEEATRQVPAPLSPAEQTLRVEPVRVGAGAPFAEPTVPVHRPNPLVPPA
                     GGPQGTRAISRAELLAPPEPKPVGPTPPTSPAARPRPKRAPKKKTPEQLYEEMRARSKR
                     QFITWLSIVVVAAILIGVTIWWLAIGSVSTVPDLVGKDETVATALLDEASLKKTVRREN
                     SDTVPSGQVISTDPPSGTKADRGDLVRLVVSAGKPVVPQVSGGVEVAAAEQEIVSVGLK
                     AQLNPAEDAFSDRVPKGKVVTLKPAPGTPVPIGSTVTIVLSKGSEPKPVPSVTGKTKDE
                     AFAELSAAGFEPVEGPTEFSDKVDGGKVIRTDPPAGTNLPPNNRRVTVVVSADSVTVPQ
                     VEGKSVKEAKKILEDAGLKVDVQFNNRDRARVVNQSVRAGERVPKDTKITIIAV"
     gene            9560..9925
                     /locus_tag="IOD16_RS05085"
                     /old_locus_tag="IOD16_05080"
     CDS             9560..9925
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657740.1"
                     /locus_tag="IOD16_RS05085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05080"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_201441207.1"
                     /transl_table=11
                     /translation="MSAIPAAADVLAPDLEVLPLPEVAERLGLPITRVHQLLRDGQLLA
                     ERRDGVLVVPAQFLAAGGVVKGLPGTITVLRDSGYSTEEILRWLFTEDETLPGTPVEAL
                     RGDRGREVKRRAQALAF"
     gene            complement(10001..10888)
                     /locus_tag="IOD16_RS05090"
                     /old_locus_tag="IOD16_05085"
     CDS             complement(10001..10888)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686266.1"
                     /locus_tag="IOD16_RS05090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05085"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_201439108.1"
                     /sec_met_domain="phytoene_synt (E-value: 8e-112, bitscore:
                     371.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.3e-63,
                     bitscore: 212.6, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="T1TS (E-value: 0.0038, bitscore: 15.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELAAAYARCRELNARHGRTFFLATRLLTPAQRPAVHALYGFAR
                     WADEIVDSGESPDPAGDLELLAAQLGDELAGRPTGHPVLVALVDTVRRYSIDPELFTAF
                     LASMRMDLTVTSYPDLPALRRYMHGSAAVIGLQLLPVFGTVAPRAQAEPGAAAMGRAFQ
                     LTNFLRDVGEDLDRGRLYLPGDVLAAYGVDRELLVWCRQTGKPDRRVRRVTAHLVACAL
                     AEYREAEAGVPLLRPVSRPCVRTALTLYRGILDEIAAADYQVLDRRVVVPNPRRLAVAL
                     PGFARALAARVVGR"
     gene            complement(11002..12495)
                     /gene="crtI"
                     /locus_tag="IOD16_RS05095"
                     /old_locus_tag="IOD16_05090"
     CDS             complement(11002..12495)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099088.1"
                     /locus_tag="IOD16_RS05095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05090"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_201439109.1"
                     /sec_met_domain="DAO (E-value: 8e-18, bitscore: 64.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAVTGRTDHVVVVGAGLAGLSAALHLLGAGRRVTVVERDAVPGG
                     RAGRLDLGGYRFDTGPTVLTMPELVDEALEAVGDSLADRLDLRPLHPAYRARFADGSTL
                     DVHSDGEAMEAEVRRFAGPREAAGYRALRRWLTELYRVEREQFIGSNFDSPLSLLRPQL
                     ARLAALRGFGRLGPSVGRFVRDERLRRVFSFQSLYAGVPPRKALAAYAVIAYMDTIAGV
                     HYPEGGMRALPDALAAAARDAGADLRFQTPVAWLERIGGRVTAVRTAHGERIPCDAVVL
                     TPDLPMSYRLLGHQPRRPVPITWSPSAVVLHAGVDRTWPELAHHTLFFGREWDRTFDEL
                     TRRGTVMSDPSLLVTAPPGQGMFVLAPAPNLRTGPIDWDRVGPAYRDELVGVLEARGLT
                     GFGAAIEVEHLVTPADWAAMGLAAGTPFSAAHTLAQTGPFRPRNLVLDNAVLAGCGTTP
                     GVGVPPVLISGRLAAQRITGATGARSRRPVEARRARTRR"
     gene            complement(12498..13565)
                     /locus_tag="IOD16_RS05100"
                     /old_locus_tag="IOD16_05095"
     CDS             complement(12498..13565)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800242.1"
                     /locus_tag="IOD16_RS05100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05095"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_123743421.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.4e-44, bitscore:
                     151.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPHPLDLELPKHVDEALAAYLADRRALGERMEENFTGAVDALAD
                     FVLGGGKRIRPTFAWWGWRAAGGDPEGELAGAVLTAVSSLELIQACALVHDDLMDASET
                     RRGMPTVHVRFAREHRAKGWLGEPERFGLAASVLIGDVALAWADDMLFAAGLPTDALQR
                     LSLPWRDMRTEMLAGQYLDVLTQARGDSSADAALRIDRLKTAAYTVERPLHMGAAIGGA
                     SPELVDGLRSFGTDIGVAFQLRDDLLGVFGDPAVTGKPAGDDLREGKRTLLVALGMEFG
                     ADVLHQALGKPDLDVATVDEVRARLREVGAVDAVEERIAELTGSALRALDRSPIAEPAG
                     ERLAELAISATKRTS"
     gene            13671..14558
                     /locus_tag="IOD16_RS05105"
                     /old_locus_tag="IOD16_05100"
     CDS             13671..14558
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0006555 - methionine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332694.1"
                     /locus_tag="IOD16_RS05105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05100"
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="WP_201439110.1"
                     /transl_table=11
                     /translation="MTSVVERLHGGSPVFSVEFFPPRDEAEEIILWRAIRELEAFDPAF
                     VSITYGAGGSARDRTIRTTGRVAQETTLLPMAHLTLVDHSVAELRNVIGWYAAVGVRNI
                     LAVRGDPPGDPNGEWLAHPEGLTYAEELVRLCRELGDFCVGVAASPYGHPRSTDLDSDT
                     EYLVRKLRAGADFAIAQLFFEPEDFLRLRDRVAARGCDTVLIPGVMPLTTPRTLAKTVE
                     LSGSSVPDSVARRLDPYADDPAGFRAAGIDLVTEVGERLLAEGVPCLHFYTFNRSKATR
                     EIVGRLGLVPARAV"
     misc_feature    13684..13699
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.75"
                     /tool="antismash"
     gene            complement(14604..15254)
                     /locus_tag="IOD16_RS05110"
                     /old_locus_tag="IOD16_05105"
     CDS             complement(14604..15254)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099092.1"
                     /locus_tag="IOD16_RS05110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05105"
                     /product="DUF3153 domain-containing protein"
                     /protein_id="WP_201439111.1"
                     /transl_table=11
                     /translation="MPRASALLMPVFLLALFSLTGCVRLHAAMALSTDDHVSGEITAAT
                     PPTKDNDPGPQLKVPNELAGRVTTKPYKVDDYVGTQLSFSGLTFDEVRALSAATSASSS
                     RYQLTFRRSGDLVTLSGSVDLTQVPPERADIQVKISFPGEIVDTNGREEDNATIAWTPK
                     PGQASMLSATVRYAGANSVSYFGWTMLVAGLTGGAALIVLVLAIVAHRRHQVA"
     gene            15359..17038
                     /locus_tag="IOD16_RS05115"
                     /old_locus_tag="IOD16_05110"
     CDS             15359..17038
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943816.1"
                     /locus_tag="IOD16_RS05115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05110"
                     /product="DUF885 domain-containing protein"
                     /protein_id="WP_123743418.1"
                     /transl_table=11
                     /translation="MSTSSAGVHGISNQFVADYAAADPLTATFIGKPGHDDRLTDYSPE
                     GHAAREELARKALAAITAAEPADKSEADAKAVFLERIGLEVELHEAGQMEGQLNVIASP
                     VQSLREVFDQMPTDTADDWAVIAKRLTAVPDAVANLRAGLAHAADRGHVSALRQVSKVA
                     EQCDTWAGRTGGRSFFATLIADAPADGALRTELEAGAKAAAESYGDLAAFLRDDLAPKA
                     PRKDAVGEDVYRLQSRYFTGSRLDLAEAYEWGWGEFTRLETEMKQVADRIKPGASLAEA
                     AAALDANPRYLVRGKDGLRSWMQELSDRALLDVRGVHFDLPDELMKLECRIAPPGGGVG
                     AYYNGPTPDFSRPGRMWWSVPDDKEEFSTWREVSTVYHEGVPGHHLQVATAVYQAETLN
                     EFQRLLCWVSGHGEGWALYAERLMRELGYLEDDGDLLGMLDAHLFRAARVIIDIGMHLE
                     LEIPKGTGFHEGERWTPDLGLEFMLTRTITDPAHVRDEIDRYLGWPGQAPSYKLGERLW
                     LAARDDARARHGAAFDLKTFHRQALEMGAMGLDTLRERLTEL"
     gene            17122..17748
                     /locus_tag="IOD16_RS05120"
                     /old_locus_tag="IOD16_05115"
     CDS             17122..17748
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800247.1"
                     /locus_tag="IOD16_RS05120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05115"
                     /product="hypothetical protein"
                     /protein_id="WP_201439112.1"
                     /transl_table=11
                     /translation="MTGRARRAALGVVLAGALLVAGSPAVGQAQPLGDQAEWRIRQQIV
                     DNALHQVGQREGNGNYYPPQYQVAGQGVLRPAEWCGVFVNWAWTTAGVQDKPAMRPAPG
                     ASVLDQGHWATYWQKWGKANGRWKDISERDVAPGDAVVYGNYPDMHAHVGLVVEVRYDR
                     TGRKATHVRTIEGNFDERVVYSKLRKIEGLNAGKYLQASGFVSPF"
     gene            complement(17812..18372)
                     /locus_tag="IOD16_RS05125"
                     /old_locus_tag="IOD16_05120"
     CDS             complement(17812..18372)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099095.1"
                     /locus_tag="IOD16_RS05125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05120"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_123743416.1"
                     /transl_table=11
                     /translation="MTAAPSQRVVALSSRELNSRLDEALALYVSAMEYPPGTAEQRAPM
                     WLAHMLRDGWRCVVALGERDELIGIGYGYRGSVGQWWHEQVRHGLTLVSGPRAVEEWMH
                     DYFELTELHVLPRAQGRGVGEQLLRNLMEGVPSSRVLLSTPEGPSKAWRLYRRMGFVDV
                     LRHYQFTGDPRPFAVLGRVLPID"
     gene            complement(18369..18869)
                     /locus_tag="IOD16_RS05130"
                     /old_locus_tag="IOD16_05125"
     CDS             complement(18369..18869)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419640.1"
                     /locus_tag="IOD16_RS05130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05125"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_201439113.1"
                     /transl_table=11
                     /translation="MSALDHPGIRKVAAALSEAGHHEAANGIRVLADAVRTAAAAAEAV
                     GVPVGAIANSLIFAAVRDGVASPLLVLTSGAHRADTAKLAVLAGADAIERATPAFVREH
                     TGQVIGGVSPVGHPAPITTFVDVALEQYEVVWAAAGHPHAVYPTTYAGLLDLTGGSSAE
                     VAR"
     misc_feature    18935..18950
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.56"
                     /tool="antismash"
     misc_feature    complement(18936..18949)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 23.59"
                     /tool="antismash"
     gene            19052..19465
                     /locus_tag="IOD16_RS05135"
                     /old_locus_tag="IOD16_05130"
     CDS             19052..19465
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099097.1"
                     /locus_tag="IOD16_RS05135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05130"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_123743414.1"
                     /transl_table=11
                     /translation="MTQTFPRRIPLPLPPASAVTLLGQARECLAEAGRDPSPPTRFATA
                     YLAAMRAAAAVLAARGRPHRGRAKPTSVWVLLPSLAPELREWAAFFAESSATRAAVLAG
                     MTRQVTQRAADDLVRQAAQFTELVDEIMYEDGL"
     gene            19462..20226
                     /locus_tag="IOD16_RS05140"
                     /old_locus_tag="IOD16_05135"
     CDS             19462..20226
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099098.1"
                     /locus_tag="IOD16_RS05140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05135"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_123743413.1"
                     /transl_table=11
                     /translation="MSRGLVAYDRLIDVVEAEAERLAASAEGQRPERQVPACPGLNLGE
                     TARHVGSTYRMVSTWLREGSQPLVWQQDPEPGQPLPEYVRAGVRPLVRALRPHEPDDPC
                     ETWWPAERNHNFWARRLAHESTVHRMDVQAAAGLPIDPVDDDVAEDGVDEILTLWLGHR
                     LDILGVRGTREGTVAIRAGDKVWLATTGPDPAVARLVTDGEASSAAGGVTGTPMQVYRW
                     LWGRIPDRDLPPTTGDHDAIAQLWALLRLATK"
     gene            complement(20323..21897)
                     /locus_tag="IOD16_RS05145"
                     /old_locus_tag="IOD16_05140"
     CDS             complement(20323..21897)
                     /EC_number="3.1.3.1"
                     /GO_function="GO:0004035 - alkaline phosphatase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099099.1"
                     /locus_tag="IOD16_RS05145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05140"
                     /product="alkaline phosphatase D family protein"
                     /protein_id="WP_201439114.1"
                     /transl_table=11
                     /translation="MAQLVLGPVLRHVDSTSATVWVETDVACEVAVAGHHAETFQVGEQ
                     HFALVVVEGLAPGATTPYDVRLDGEVVWPRPDSPFPAPRIRTTPVRRLLFGSCRAAKGE
                     GTPDKLGPDALDAYALRMVDESPEQWPEALVLLGDQVYADEPTPRIKQWLAERRPEPAG
                     EVVSFREYAELYHESWADPEIRWLMSVVPTSMIFDDHDVRDDWNTSRPWREQMAAKRWW
                     PERIRAGLASYWVYQHLGNLSPDELANDELYAKVRSTGGDVQALLEDFGEQADREVDGG
                     KSTRWSYRRDFGRVRLLVIDTRSGRILDGPQRLMVGDAEFDWIEANAEGDFDHLLIGSS
                     LPWLMPHGLSHFQSLNERMAGLPGWRGRVGEKVRQVADLEHWPAFRASFERLARLLERI
                     SRGDDAPGTVCVLSGDVHHSYAARAAFAGSVDAKVYQLVCSPVHNDPPWVFRPAFRLSW
                     SKPIARVLRRWADRRGISPDPVSWHKLSGPHFGNSVGVLEIDGRAIRFRLETATGEGLS
                     EVTSLAL"
     gene            21945..22631
                     /locus_tag="IOD16_RS05150"
                     /old_locus_tag="IOD16_05145"
     CDS             21945..22631
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671613.1"
                     /locus_tag="IOD16_RS05150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05145"
                     /product="VOC family protein"
                     /protein_id="WP_328809419.1"
                     /transl_table=11
                     /translation="MVDSTDPAALGRFWSALLGLPITGEGDDEVDVALGDGQELVFGLA
                     PDVKEVKNRVHLDLASTSPEDQAAIVARAVALGAKPVDIGQGDVPWVVLADPEGNEFCV
                     LEQRDEYAHTGPVAAVVVDASDPPALAAFWAGPTGLPVTRSAAGFASLAQEAGPSLEFV
                     RVAEPKVVKNRLHLDLAPFADGDLPTEVARLEAWGAVRVDVGQIDVPWTVLADPEGNEF
                     CVLTPR"
     gene            complement(22639..23553)
                     /locus_tag="IOD16_RS05155"
                     /old_locus_tag="IOD16_05150"
     CDS             complement(22639..23553)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005450093.1"
                     /locus_tag="IOD16_RS05155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_05150"
                     /product="RNA polymerase sigma-70 factor"
                     /protein_id="WP_268957679.1"
                     /transl_table=11
                     /translation="MARTEHVDEHLADLATGAFVAHRNLLFTVAYEMLGSAADAEDVLQ
                     EVWLRWARVDLAQVRDQRAYLVRITTRQALNRLRALRRRKESYVGSWLPEPMLTAPDVA
                     LDVELAESVSMALMLVLETLSPTERAVFVLREAFGVGYDEIAAAVDKTPAAVRQIAHRA
                     RRHVDARRPREAVSPGEARAALESLRRALEDGDVPGLLAVLAPDVVLVSDGGGVKRAVP
                     RPVVGADKVVRMVLGGLGRLESAFTGEAVVVNGNPALVVRFDGEVDGVMAIRVEDARIT
                     GLYYVRNPEKLTRVGAETPLARR"
ORIGIN
        1 tcaccttccc ggccaagatc gagtacttca ccggcaaggg gctcaagggc cggttccagc
       61 gctggttctt ctacggcgtc ggccaggtgc cgatcgaccg gtccagcgcg tcggccgccc
      121 agggcgcgct cgacaccggt gtgcggatcg tgcgcgaggg caagctgctc ggcatctacc
      181 ccgagggcac ccggtcgccc gacggccggc tgtacaaggg caaggtcggc gtggcgtgga
      241 tcgcgctgga gtccggcgcg ccggtcatcc cggtcgcgat gttcggcacc gacaaggcca
      301 accccatcgg ctcgaagatg tggcggccgt acccgatccg gatcaagatc ggcaagccgc
      361 tggacttctc ccgctacgag ggactgtccg gcgaccggtt cgtgctgcgg tccatcaccg
      421 acgagatcat gtacgcgctg atggagctgt ccggtcagga gtacgtcgac gtctacgcgg
      481 ccaaggccaa ggagggccag ggcgacgggc ggggcgacgg gaagccggcg aaagcggtcg
      541 atcggctgcc cgaggcgaag gcgggctgaa ccgcacccct aggctggcgg ggtgcggttc
      601 ttctacgact gtgagttcat cgaggacggg gtcaccatcg acctcgtctc catcggagtg
      661 gtcgacgagg aaggccgcga gttctacgcc gtgtcgaccg agttcgaccc ggccaaggcc
      721 ggaccgtggg tgcgcgccaa cgtgctcaac cagctgccgt cgcccgccga ccgggcgtgg
      781 cgcagccggg agcggatccg cgcggacctc ctcgacttcc tcggcgggcc caaggccaac
      841 cgggacgaca tcgagctgtg ggcctggttc gccgcctacg accacgtggc gctggcccag
      901 ctctggggtc cgatgccggc cctgccgcgc tgcctgcccc gcttcacccg cgacctgcgg
      961 cagcgctggg aggacgtggg caaaccccac ctgccgcccg cgcccgcgga cgcgcacgac
     1021 gccctcgccg acgcccggca caacctcgcg cgctggaagg tgatcgagtc cgaacgactg
     1081 cggaagggct tcgcggtccg gtaggtggac cctcgcttgc tgcaccgatc cagcacgtgt
     1141 caggcttggg tgaccaacgc cacgagaaga gattggctaa gcaaatgcgc attggtgtgc
     1201 tcaccggcgg tggcgactgc cccggcctca acgcggtcat ccgcggcgtg gtccgcaagg
     1261 gcatcgaggc ccacggctgg gacatcgtgg gattccgcaa cggttggcag ggcccggtgg
     1321 agaacctgac caagccgatc gggctcgatg acgtcgagga catcctcacc aggggcggca
     1381 ccatcctcgg ctcgtcgcgc accaacccgt acaagatcga cggcggggtg gaccggatcc
     1441 gcgagaccct cgccgcgaac caggtcgacg cgctgatcgc catcggcggc gaggacaccc
     1501 tcggcgtcgc caagcggctc accgacgacg gcatcggcgt cgtgggcgtg ccgaagacca
     1561 tcgacaacga cctgggcgcg accgactaca cgttcggttt cgacaccgcc gtgcacatcg
     1621 ccaccgaggc gatcgaccgg ctgcgcacga cggccgagtc gcaccaccgg gcgctcgtgg
     1681 tcgaggtcat gggccgccac gcgggctgga tcgcgctgca ctccggcctg gccggcggcg
     1741 cgaacgtgat cctggtgccc gagcgccagt tcagcgtcga caaggtggtc gagtgggtgg
     1801 agcggcgctt cgagcgccag ttcgccccga tcatcgtggt cgccgagggc gcgatgcccg
     1861 agggcggcgc cgagacgctg cactccggtg agaaggacgc gttcggccac gtgcggctgg
     1921 gcggcatcgg cacctggctg gccgaggaga tcgcggagcg gaccggcaag gagtcccgcg
     1981 cggtcgtgct gggccacgtc cagcgcggcg gcatcccgac cgcctacgac cgcgtgctcg
     2041 ccacccggtt cggcctgcac gcggtggacg cggtcgccga cggcgacttc ggcgtcatgg
     2101 tcgcgctgcg cggcacggac atcgtccggg tcaagctgtc cgaggccacc gaggagctga
     2161 agaccgttcc gctggagcgc taccaggagg ccgaggtctt cttcggctga gtcgcccgcc
     2221 ggccgccccg ggcagcggtg gtccgacgac ggccccgggc accggcgatc cgacgacgag
     2281 cgccctcgga cttcacgtcc gggggcgctt cgcggtgtcg cggctacttc tcggcgtagt
     2341 cgtgcaggcc ggtgaagtcg accatcacgc acggctcgtc gcccacgatc caggcgtcgt
     2401 gccccggctc caccacgatc gcctccccgg ctcccgcctc gccctcggag ccgtcgtcca
     2461 tgacgacgtg catccggccg gacaggatgt agccggtgtg ggaggcctgg cacgagtcgg
     2521 tgcccgcgat cggcttcacg tcctgcgacc accgccagcc cggctggaac tccgctctgc
     2581 cgaccgtcgt gccgccgacg gtgaccaggt cgacgtgacc gtgcgggaag tcccgcacct
     2641 cttccggctc ggccaagctc ttcgacgcca ccgaagacat ctccgtcacc ttcctcgtcg
     2701 tctcagccct gcaccacggg gtagatctcg tccgccacga ggccgtgcgc ctcgcggtgg
     2761 acccggtgcg ccgtctccgc gtccggcgcg tcgaccaggc agaagacctt cccgtccttc
     2821 tcgtccaccc agtagttgag gtactggacg ccgtaccggt cctgggtgcg gaggtcggcg
     2881 gcgtgcgcct cggccacgtc accgggaccg gcgccttcgg gcaggtggtt gtgcacgtcc
     2941 atgaacaaca tggggtcctc ccgactcgga gtggatcggg acacgctagg cggcgcggcg
     3001 ttcccaaacc gttcccgcgg cggtcccgcc gggccggacg tagggtgccg ccatgcgggc
     3061 cacctgccag gtgcgcgtgc tgggcgggtt cgccgtcgcg gtcgacggca gaccggtccc
     3121 cggtgacgtg tggcgcaacc ggcgcgcggc cgacgtggtg aagctgctgg ccgtggcgcc
     3181 cgaccaccgg ctgcaccgcg agcaggtgat ggaccggctg tggcccgacc tgcccgccga
     3241 cgcggcgggg gcgaacctgc gcaaggcggt gttctacgcg cggcgcgcgc tgggacgtgc
     3301 cgacgccgtc cggtgcgagg gccggctgct gacgttgtgg cccggcggcg acctggacgt
     3361 ggacctggac cggttccagc gggccgccga cgccgcgctg gcctcgggtg acgccgagcg
     3421 gtgcgcgctg gccgccgccg ggtaccgcgg cggcctgctc gtcgacgacc gctacgagtg
     3481 ctgggtcgcg gagccgcacg acaaggtcga gggccgctac gccgcgctgc tgagggccgc
     3541 cggcgactgg gaacggctgc tcgacctgga cgagaccgac gagcaggcgc accgcgcggt
     3601 gatgcgccgg cacctggccg ccggtcgccg cggggaggcg ttgcgccagt tcgaccggct
     3661 gcgccgcacg ctgcgggagc ggatcggggt cgggccggac gcggagaccg tcgagctgta
     3721 cgagtcggcg ctcagcctcg acgcggccga gccgccgtca ccggcgcagc gcgcggcggt
     3781 cgcgctggcc aacgggctgg tcgcgttcgg gcgccgccac ctcgccgagg ccgaacggct
     3841 ggccaggcag gcgcgggtgc tggcgctgga cgccgacctc gggcacgagc tgggcgaggc
     3901 ctcgaccctg ctcgccctcg tcgcgcacgc ccgcggcacg tggcaccggc tgttccggga
     3961 ggagttcgcc gacgcggtgc ggcacccgtc ccggcccgtg gtctacgacg cgcacctgtg
     4021 tttgcaggag ttctacctgt acgggccgga ggggcacgac ggcgcggagt cgttcggccg
     4081 cgacctgctc gacatcgcgt cacgggcggg ttcggcggcg ggccgggcgt tggcctacct
     4141 gctgctgggc gagttcgcgc tgctgtccgg gcgcctcgac gacgccgtga ccacgctggg
     4201 cgagtcgctg gtcgagaccg aacgcgccgg ctgcgggtcc gcccggtccc tggcgctgga
     4261 acggcgggcc gaggccgagg cccggcgcgg cgaccgggcg gcggcccgtg ccgacctgga
     4321 cgaggcgctg ccgctggccc gctcctcacg cataccgtcg cacctggtca tccgggtgca
     4381 cggggtccgc gtcctggccg cgggcaccct cggcggcgcg ctcggcgcga tccgcgaggc
     4441 cgagcggtgg ctcaccgagg cgccgcacgt gtgcgacccg tgctcgatgg gcttccggat
     4501 cgcggcggcg acggcgtgcg cgaacgcggg cagcccgagc cgcgcccggc cgcacctggc
     4561 ggaggcggag cggatcagcg gcctctggca gggcggcccg tggacggcgg cgctgtggga
     4621 ggtgcgcgcc gaggtccggc gcgcgcaggg gcagcgcacg cgggcgacgg cgttgttcct
     4681 ggaggcggcc gagcggttcg cggcgatgcg ccgaccgctg gaggagcgcc ggtgccgggc
     4741 cgccgccgcg tccctcagcg accggtgaac gcgccgaggt ccaggtaggc ggcgaacgtg
     4801 cccagccagt gctcggcgta gtagccgtgc ccggacacca gccgcagacc ggtctcccgg
     4861 tgcgcctcgg ccgcggtgcg ggccaggtcg gcgtaccggt gccccggcgg cagcgcgtcg
     4921 gcgacggccc gccactgcca cgcccgcgac agcgccagcc cgaccaggtg cgagccgtgc
     4981 gggtcgcccg ggtcgtccac cggcacgggt tcgcgcagca ccttccagcg cgagtcgtcc
     5041 aggtgcggga ggaacgcctc gaaccacgcg gtgaacccgt cggccggcag cacccgccgc
     5101 atcaggtccg cctcggtcag cgcgggcgag aggaagtccg ccgcgtccgg ttcgaacccg
     5161 ccgtacccga cgtcctcccg gtgccaccgc aacgccgcct ccgcgcacgc cgaggccagc
     5221 tccccgtcgc ccaccgcgcg cgccgcgtcc agcacgagcc cggtcgcgaa cgccgtgttg
     5281 ccgtgcgtgc cggtccgcac gggcagccgc gcgccggtca ccttggcgag ataccggtca
     5341 cgcagcaccg cgctcaacgg ccgcagcgcc gccgccagcg gcgggtccca ggcgcggagc
     5401 tcggcgtcga gcacgagcag ccacgcccac ccgtagggcc gctcccagaa cccgccggag
     5461 ggcccgtcga agaacgccgc ctcgacctcc gcgttcccga ccgtgatcaa cgactccagc
     5521 acccggcggg cctgcgccgc gccctcgacc ccgggccgca cccgcagcag ccggaccgcc
     5581 aaccaggtct gatgcacgca cgagtgccag tcgaacgacc cggcgaagat cgggtgcagc
     5641 acgcgctgcg gcaccaggtc ggcgtcgccg gcgacgacgt gcgaccagtg cgccgggtag
     5701 tcccgctgga cgttctccac cgcggtcgac agcagcctgg ccgccgtgct gtcatccaat
     5761 cgggtgtccg acatggtcca cataatgcac aggtcggacc cgcgtccgtc tctcgatgtg
     5821 gacagctatc tttaacgtgt gaactggacc gtggacgtgc ccgtggacac gcttcccgag
     5881 cttccgcccc tcccgcccga gctgcgcgac cggctcgacg acgcgctgag ccgccccgcc
     5941 gcccagcagc cggagtggcc ggacgcggag caggtgcgcc gggtgcgcgc cgtgctggag
     6001 agcgtgccgc cgatcaccgt gccggccgag atcgaccggc tgcgcgacaa cctggccgag
     6061 gtcgcccgcg gcgaggcgtt tctgctgcag ggcggcgact gcgcggagac gttcgcggac
     6121 aacaccgagc cgcacatccg cgcgaacgtc cggaccctgc tccagatggc cgtcgtgctc
     6181 acctacggcg cgagcctgcc ggtggtgaag atcggccgca tcgcgggcca gtacgccaag
     6241 ccgcgctcgt cgggcatcga cgcgctcggc ctgccgtcct accgcggcga catcgtgaac
     6301 tcgctggtcg ccacgcccga ggcgcgcgtg ccggacccgt cccggatgat ccgcgcctac
     6361 gccaacgcgg gcgcggcgat gaacctgctg cgcgccatga ccaccgcggg catggccgac
     6421 ctgcaccggc tgcacgactg gaacaaggac ttcgtccgcc agtcgcccgc cggcgagcgg
     6481 tacgaggcgc tggccggcga gatcgaccgc ggcctgcggt tcatgtcggc gtgcggcgtg
     6541 aacgacacgt cgctgcacac caccgagatc ttcgcctcgc acgaggcgct gctgctggac
     6601 tacgagcggg ccctgctgcg cctggacacc aacggcgagc agccgaggct gtacgacctg
     6661 tcgtcgcact tcctgtggat cggcgagcgg accaggcagc tggacggcgc gcacatcgcg
     6721 ttcgccgagc tgctgtccaa cccgatcggg ttgaagatcg gcccgtcgac cacgccggag
     6781 atggccgtcg agtacgtcga gcggctcgac ccgcacaacc agccgggccg gctgaccctg
     6841 atcagccgca tgggcaacgg caaggtgcgc gacgtgctgg gcccgatcgt ggagaaggtc
     6901 accgcctccg gccaccaggt catctggcag tgcgacccga tgcacggcaa cacgcacgag
     6961 gcgtccaccg gctacaagac ccggcacttc gaccggatcg tcgacgaggt gcagggcttc
     7021 ttcgaggtgc accggcgcct gggcacccac cccggcggca tccacatcga gctgaccggc
     7081 gaggacgtca ccgagtgcct cggcggcgcg caggagatct ccgacctgga cctcgcgggc
     7141 cgctacgaga cggcctgcga cccgcggctg aacacgcagc agtcgctgga gctggcgttc
     7201 ctggtcgcgg agatgctgcg cagctgaccg gacgacgccg accgacgcgg aacggcggtg
     7261 gcccccgact cccacgagtc gggggccacc gccgtcccgc cgccctacac cgcgatgatc
     7321 gtgatcttgg tgtccttggg cacgcgctca ccggcccgca cggactggtt gaccacgcgg
     7381 gcccggtcgc ggttgttgaa ctggacgtcg accttgaggc ccgcgtcctc caggatcttc
     7441 ttcgcttcct tgaccgactt gccctcgacc tgcggcaccg tcaccgagtc cgccgacacc
     7501 acgacggtca cccgccggtt gttgggcggc aggttcgtgc ccgcgggcgg gtcggtgcgg
     7561 atcaccttgc cgccgtcgac cttgtcggag aactcggtcg ggccctcgac cggctcgaac
     7621 ccggccgcgc tcagctcggc gaacgcctcg tccttcgtct tgcccgtgac gctgggcacc
     7681 ggcttgggct ccgagccctt gctcagcacg atcgtcaccg tcgagccgat cggcaccggg
     7741 gtgcccggcg cgggcttcag cgtcaccacc ttgcccttgg gcacgcggtc gctgaacgcg
     7801 tcctcggcgg ggttgagctg ggccttcaac ccgaccgaca cgatctcctg ctcggccgcg
     7861 gcgacctcga cgcccccgct gacctgcggc accaccggtt tgcccgcgga caccacgagc
     7921 cgcaccaggt caccgcggtc ggccttggtc ccggagggcg ggtcggtgct gatcacctgc
     7981 ccgctcggca cggtgtcgct gttctcccgg cgcaccgtct tcttcaacga cgcctcgtcc
     8041 agcagcgcgg tggcgacggt ctcgtccttg ccgaccaggt ccggcacggt ggagacgctg
     8101 ccgatggcca gccaccagat cgtcacgccg atgaggatcg cggccaccac gacgatgctg
     8161 agccacgtga tgaactgccg cttgctgcgc gcccgcatct cctcgtacag ctgctcgggc
     8221 gtcttcttct tcggcgccct cttgggacgc ggacgggccg ccggggacgt cgggggagtg
     8281 ggtccgaccg gcttgggctc gggcggcgcg agcagctcgg cccgggagat ggccctggtg
     8341 ccctgcgggc cgcccgccgg cggcaccagc gggttcggcc ggtgcaccgg cacggtcggc
     8401 tcggcgaacg gcgcgcccgc gcccacccgc accggctcca cccgcaacgt ctgctcggcc
     8461 gggctcagcg gcgccggcac ctgccgggtg gcttcctccg cgggcgccgc cgcgctgggc
     8521 accggcacgt cgaccgccgc gatgccgagc acggcccgcg cggtctccac ctcggacagg
     8581 aacgactcgg cgtccgcggg ccgcaggaac ggctccttgc gggtcgcccg gcgcaccagc
     8641 tccgcgacct cggcgggcac gcccggcacc ggcggcacgt cgtcgttcac gtggcggtag
     8701 gccaccgaga tggcgttgtc gcccacgtac ggcggcgcgc cggtcagcat ctcgtacagc
     8761 agcacgcccg ccgagtacac gtcgctgcgc gcgtccgtgg tgcccgtggt gacctgctcg
     8821 ggcgacaggt aggcgaccgt gcccaggatc atggtgtcgc tggtcacgcc cactgtggag
     8881 accgcgcgga ccaggccgaa gtcggcgacc ttcaccgtgc cgccggggcc gatgagcacg
     8941 ttctccggct tcacgtcccg gtgcacgagg tcggcgcggt gggcggcggc cagcggcgag
     9001 aggaccttct cgatgacggt gagcgccagc ggcacgtcca gcgtgccgcg cgcggtgagc
     9061 aggtcgcgca gcgtgccgcc ctcgaccagc tccatgacga ggtacacccg gtcctcgtcc
     9121 acgccctggt cgtggacctg caccacgccg gggtggtgca gcttggccgc ggcccgcgcc
     9181 tcgcgctcga accgcgccac gaactgcggg tcggcggaga accggggatc catgaccttg
     9241 atggccacgg tccgctccaa gcgggtgtcc acacctcggt agacggtgga catgccgccc
     9301 cgcgcgacca gggcgcctac ccggtagcgt tgttcgagca gcccgccgat cacgttcgtc
     9361 gccgaccttt ccacagccgt ggatcgtacg gtgggtggtg ccgaccgagt gctgtgcgct
     9421 ggagcatccc acgcgcgctt gtgggatccg cgtcaaagtg gcgcgaaaca gggggtagcg
     9481 gcaagccgac ccctgggtgt acggccacca cccggttggc gcagggcgtc gtccacgtcg
     9541 ttgtggcatc gtgacgcagg tgagtgcgat tcctgccgct gcggatgtgc tggctcccga
     9601 cctggaggtc ctgcccctcc ccgaggtcgc cgagcgtctt ggcctgccta tcacccgagt
     9661 ccaccagttg ctgcgcgacg ggcaactgct ggccgagcga cgcgacggcg tcctcgtcgt
     9721 ccccgcgcag ttcctcgccg ccggaggcgt ggtgaagggc ctgcccggca ccatcacggt
     9781 gctgcgcgat tccggctact cgaccgagga gatcctccgg tggctgttca ccgaggacga
     9841 gaccctgccc ggcacgcccg tcgaggcgtt gcgcggcgac cgcggccgtg aggtgaagcg
     9901 gcgggcacag gccttggctt tctgacgagc accgcaccac cccagacgac cgaccacgtc
     9961 cgggcggctg cccagccgcc cggacgtcgt gccctccggg ctagcgcccg acgaccctcg
    10021 ccgccagcgc ccgcgcgaag ccgggcagcg ccaccgccag ccgccgcggg ttcggcacca
    10081 ccacccgccg gtccagcacc tggtagtcgg ccgccgcgat ctcgtccagg atcccccggt
    10141 acaacgtgag cgcggtccgc acgcacggcc gcgacacggg ccgcagcagc ggcacacccg
    10201 cctcggcctc ccggtactcc gccagcgcgc acgcgaccag gtgcgccgtc acccgccgca
    10261 cccgccggtc gggcttcccg gtctgccggc accacaccag cagctcgcgg tcgacgccgt
    10321 aggccgccag cacgtccccc ggcaggtaca gccggccccg gtcgaggtcc tcgccgacgt
    10381 cgcgcaggaa gttcgtcagc tggaacgccc ggcccatcgc ggcggcgccc ggctccgcct
    10441 gcgcgcgggg cgccaccgtc ccgaacaccg gcagcagctg aagcccgatc accgccgccg
    10501 agccgtgcat gtaccgccgc aacgccggga ggtccgggta cgacgtgacg gtcaggtcca
    10561 tccgcatcga cgccaggaag gcggtgaaca gctccgggtc gatcgagtac cggcgcacgg
    10621 tgtcgaccag cgcgaccagc accgggtggc ccgtcggccg gcccgccagc tcgtcgccca
    10681 gctgcgccgc cagcagctcc aggtcaccgg ccgggtcggg cgactcgccg ctgtccacga
    10741 tctcgtcggc ccagcgcgcg aagccgtaca gggcgtgcac cgcgggccgc tgcgcgggcg
    10801 tgagcaggcg ggtggcgagg aagaacgtgc ggccgtggcg ggcgttcagc tcacggcagc
    10861 gggcgtacgc cgcggccagc tccgtcacga ccggccccgg gtagcccgcg accgcaccgg
    10921 ctcgacaggt gcggcgctcg atcgggtgaa ggtgctcggg gtcatcgggg cgacatcgtc
    10981 gcacagcgcc accccggcgg gtcagcgccg ggtgcgcgcc cgccgtgcct cgaccggccg
    11041 ccgcgacctc gcgcccgtcg cccccgtgat ccgctgggcg gccagcctgc ccgagatcag
    11101 caccggcggc acgccgacgc ccggcgtggt gccgcagccc gccagcaccg cgttgtccag
    11161 cacgaggttg cgcggccgga acggcccggt ctgggcgagg gtgtgcgcgg ccgagaacgg
    11221 ggtgcccgcg gccaggccca tcgcggccca gtccgcgggc gtgaccaggt gctcgacctc
    11281 gatcgcggca ccgaacccgg tgagcccgcg cgcctccagc acacccacca gctcgtcgcg
    11341 gtaggccggg ccgacgcggt cccagtcgat cgggccggtg cgcaggttcg gcgcgggcgc
    11401 cagcacgaac atcccctgcc cgggcggggc cgtgaccagc agcgacgggt cgctcatcac
    11461 cgtgccgcgg cgggtcagct cgtcgaacgt ccggtcccac tcccggccga agaacagcgt
    11521 gtggtgcgcc agctccggcc acgtccggtc cacgcccgcg tgcagcacga ccgccgacgg
    11581 cgaccacgtg atcggcacgg gccggcgcgg ctggtgaccc agcaggcggt acgacatcgg
    11641 caggtccggg gtgagcacca ccgcgtcgca cgggatgcgc tcgccgtgcg cggtgcgcac
    11701 cgcggtgacc cgcccgccga tccgctccag ccacgccacc ggcgtctgga accgcaggtc
    11761 cgcgcccgcg tcccgggccg ccgccgccaa cgcgtccggc agcgcccgca tcccgccctc
    11821 ggggtagtgc acgcccgcga tggtgtccat gtacgcgatg acggcgtacg cggcgagggc
    11881 cttgcgcggc ggcacgcccg cgtacagcga ctggaacgag aacacccgcc gcaaccgctc
    11941 gtcgcgcacg aaccgcccca ccgacgggcc gagccggccg aacccgcgca gcgcggccag
    12001 cctcgccagc tggggcctga gcagcgacaa cggcgagtcg aagttcgagc cgatgaactg
    12061 ctcgcgctcc acccggtaca gctcggtcag ccagcggcgc agcgcccggt acccggcggc
    12121 ctcgcgcgga ccggcgaacc ggcgcacctc ggcttccatc gcctcgccgt cggagtgcac
    12181 gtccagcgtg ctgccgtcgg cgaagcgggc ccggtaggcg gggtgcagcg gccgcaggtc
    12241 cagccggtcg gccagcgagt cgccgaccgc ttccagcgcc tcgtccacca gctccggcat
    12301 ggtcagcacg gtcggcccgg tgtcgaagcg gtagccgccg aggtccagcc gcccggcccg
    12361 gccgccgggc acggcgtccc gctcgaccac ggtgacccgg cggcccgcgc cgagcaggtg
    12421 cagcgcggcg gacagccccg ccagccccgc gccgaccacg acgacgtggt ccgtgcggcc
    12481 ggtgaccgcg cgcatcgtca ggaggtccgc ttcgtggcgc tgatcgccag ctccgccagc
    12541 cgctcaccgg ccggttcggc gatcggggac cggtcgagcg cccgcagcgc ggacccggtc
    12601 agctcggcga tccgctcctc caccgcgtcc accgcgccga cctcgcgcag ccgcgcgcgc
    12661 acctcgtcga ccgtggccac gtccaggtcg ggcttgccca gcgcctggtg cagcacgtcc
    12721 gcgccgaact ccatgcccag cgcgaccagc agcgtccgct tgccctcgcg caggtcgtca
    12781 cccgcgggtt tgccggtgac cgccgggtcg ccgaacacgc cgagcaggtc gtcgcgcagc
    12841 tggaacgcca cgccgatgtc cgtgccgaac gagcgcaggc cgtccaccag ctccggtgac
    12901 gccccgccga tcgccgcgcc catgtgcagc ggccgttcca cggtgtacgc ggcggtcttg
    12961 agccggtcga tgcgcagcgc cgcgtccgcc gagctgtcgc cgcgcgcctg cgtgagcacg
    13021 tccaggtact ggccggcgag catctcggtg cgcatgtccc gccacggcag gctcagccgc
    13081 tgcaacgcgt cggtgggcag gcccgcggcg aagagcatgt cgtccgccca ggccagcgcc
    13141 acgtccccga tcagcacgga cgcggccagc ccgaaccgct cgggttcgcc cagccagccc
    13201 ttggcgcggt gctcgcgggc gaaccggacg tgcacggtgg gcatgccgcg gcgggtctcg
    13261 gaggcgtcca tcaggtcgtc gtgcaccagc gcgcacgcct ggatcagctc cagcgagctg
    13321 accgccgtga gcacggcccc ggccagctcg ccctccgggt cgccgccggc ggcgcgccac
    13381 ccccaccacg cgaacgtggg ccggatccgc ttgccgccgc cgagcacgaa gtcggccagc
    13441 gcgtccacgg cgccggtgaa gttctcctcc atgcgctcgc ccagtgcccg gcggtcggcg
    13501 aggtacgcgg ccaacgcttc gtcgacgtgc ttgggcagtt cgaggtccaa cgggtggggc
    13561 ggcacgcctc tatcgtcacc tctgcgtctt cggcgcgccc aaccgggggg ctggtcccat
    13621 ccagtgacag ccttcttcca cgcctcggac gaacctctag gctgtcgggc atgacgtcgg
    13681 tggtcgaacg cctgcacggg gggtcccccg tgttctccgt cgagttcttc cccccgcgcg
    13741 acgaggccga ggagatcatc ctctggcgcg cgatccgcga gctggaggcc ttcgacccgg
    13801 cgttcgtgtc catcacctac ggcgcgggcg ggtcggcgcg cgaccggacc atccgcacca
    13861 ccggtcgggt ggcgcaggag acgaccctgc tgccgatggc ccacctcacc ctggtcgacc
    13921 actcggtggc cgagctgcgc aacgtgatcg gctggtacgc ggcggtgggc gtgcgcaaca
    13981 tcctggccgt gcgcggcgac ccgccgggcg acccgaacgg cgagtggctc gcgcacccgg
    14041 agggcctgac ctacgccgag gaactcgtcc ggctgtgccg tgagctgggc gacttctgcg
    14101 tcggcgtggc cgcgtcgccg tacggccacc cccggtcgac ggacctggac tccgacaccg
    14161 agtacctggt gcgcaagctg cgcgccggcg ccgacttcgc catcgcgcag ctgttcttcg
    14221 agccggagga cttcctgcgc ctgcgcgacc gggtcgccgc acgcggctgc gacaccgtgc
    14281 tgatccccgg cgtgatgccg ctgacgacgc cgcggacgct ggcgaagacg gtggagctgt
    14341 cgggttcgtc ggtgccggac tccgtggcgc gccgcctcga cccctacgcc gacgacccgg
    14401 cgggtttccg cgcggcgggc atcgacctgg tgacggaggt gggggagcgg ctgctcgccg
    14461 aaggcgtgcc gtgcctgcac ttctacacct tcaaccggtc gaaggcgacg agggagatcg
    14521 tcggccgcct gggcctggtc ccggcccgcg ccgtataggg tttgccgccg ctgcgcggac
    14581 ggcggcgcgg tcgcggggct gggtcaagcc acttggtggc ggcggtgggc gacgatggcc
    14641 aggaccagca cgatgagcgc cgcgccgccg gtcaagccgg ccaccagcat cgtccagccg
    14701 aagtaggaca ccgagttcgc gcccgcgtag cggactgtcg cgctcaacat cgaggcttgg
    14761 ccgggtttcg gggtccacgc gatggtcgcg ttgtcttctt ctcgcccgtt cgtgtcgacg
    14821 atctcacccg gaaagctgat tttcacttgg atgtcggcgc gttcgggcgg cacctgcgtc
    14881 aggtcgaccg atccggacaa cgtcacgagg tcgccggagc gccggaacgt cagctggtag
    14941 cggctggacg acgcgctggt cgccgctgac agggctcgca cctcgtcgaa cgtcaacccg
    15001 ctgaacgaca gttgcgtgcc gacgtagtcg tccaccttgt acggcttggt ggtgacccgt
    15061 ccggcgagtt cgttgggcac tttcagctgt ggacctgggt cgttgtcctt cgtcggcggg
    15121 gtggcggcgg tgatctcgcc ggacacgtgg tcgtcggtgg acaacgccat ggcggcgtgc
    15181 agccggacgc accccgtcag cgagaacagc gcgaggagga agaccggcat gagcagcgcg
    15241 gaggccctgg gcacccggcc atcctgccgg ccacggtcaa aagttgaccg catgacacga
    15301 tcgtgagcgt ggctaattac ctgttggggg gacagggccc gcaggtaacg tgccgcgcat
    15361 gtcaacctcc tccgccggcg tgcacggcat cagcaaccag ttcgtggccg actacgcggc
    15421 cgcggacccg ttgaccgcga cgttcatcgg caagcccggc cacgacgacc ggctcaccga
    15481 ctactcgccg gaggggcacg cggcccgcga ggagctggcg cgcaaggcgc tcgcggcgat
    15541 caccgccgcc gagcccgcgg acaagtcgga ggccgacgcc aaggccgtgt tcctggagcg
    15601 catcggcctc gaggtcgagc tgcacgaggc cggtcagatg gaaggccagc tcaacgtcat
    15661 cgcgagcccc gtgcagtcgc tgcgcgaggt gttcgaccag atgcccaccg acacggccga
    15721 cgactgggcg gtgatcgcca agcggctcac cgccgtgccg gacgccgtgg cgaacctgcg
    15781 cgcgggtctc gcccacgccg ccgaccgggg ccacgtctcg gcgttgcggc aggtaagcaa
    15841 ggtcgccgag cagtgcgaca cctgggcggg taggaccggc ggcaggtcgt tcttcgccac
    15901 cctgatcgcc gatgcccccg cggacggcgc gttgcgcacc gagctggagg cgggcgcgaa
    15961 ggccgccgcg gagtcctacg gcgacctggc cgcgttcctg cgcgacgacc tcgcgcccaa
    16021 ggcgccgagg aaggacgcgg tcggcgagga cgtctaccgg ctccagtccc gctacttcac
    16081 cggctcccgc ctcgacctgg ccgaggccta cgagtggggc tggggcgagt tcacccgcct
    16141 cgagaccgag atgaagcagg tcgcggaccg gatcaagccg ggcgcttccc tcgccgaggc
    16201 cgccgccgcg ctggacgcga acccgcgcta cctggtgcgc ggcaaggacg gcctgcggtc
    16261 gtggatgcag gagctgtcgg accgggcgct gctggacgtg cgcggcgtgc acttcgacct
    16321 gccggacgag ctgatgaagc tggagtgccg catcgcgccg cccggcggtg gtgtcggcgc
    16381 gtactacaac ggccccacgc cggacttctc ccgccccggc cgcatgtggt ggtccgtgcc
    16441 ggacgacaag gaggagttct ccacctggcg cgaggtctcg accgtctacc acgagggcgt
    16501 gccgggccac cacctccagg tcgccacggc cgtctaccag gcggagacgc tcaacgagtt
    16561 ccagcgcctc ctgtgctggg tctccggcca cggcgagggc tgggcgctgt acgcggagcg
    16621 gctgatgcgc gagctcggct acctggagga cgacggcgac ctgctcggca tgctcgacgc
    16681 gcacctgttc cgcgcggccc gcgtgatcat cgacatcggc atgcacctgg agctggagat
    16741 ccccaagggc accggtttcc acgagggcga gcggtggacc ccggacctgg gcctggagtt
    16801 catgctcacc cgcaccatca ccgacccggc gcacgtgcgc gacgagatcg accgctacct
    16861 gggctggccc ggtcaggcgc cgtcgtacaa gctgggcgag cggctgtggc tggcggcccg
    16921 cgacgatgcc cgcgcccggc acggcgccgc gttcgacctc aagacgttcc accgccaggc
    16981 cttggagatg ggggccatgg ggttggacac tcttcgtgag cggctcacgg agctctgacc
    17041 ccgacccggt gacctcggtt tcacgccgag gtcaccggat ccggtgtttg atgtgctggc
    17101 gaacgaccgt agggggatgt gatgaccgga cgtgcgaggc gtgccgcact cggcgtggtg
    17161 ctggccggcg cgttgctggt cgccgggtcg cccgcggtcg gccaggccca accgctcggc
    17221 gaccaggccg agtggcgcat ccggcagcag atcgtcgaca acgccctgca ccaggtcggc
    17281 cagcgcgagg gcaacggcaa ctactacccg ccgcagtacc aggtggcggg ccagggcgtg
    17341 ctgcggccgg ccgagtggtg cggcgtcttc gtcaactggg cctggaccac cgccggcgtg
    17401 caggacaagc cggcgatgcg ccccgctccc ggcgcgtccg tcctcgacca gggccactgg
    17461 gcgacctact ggcagaagtg gggcaaggcc aacggccggt ggaaggacat ctccgagcgc
    17521 gacgtggcgc ccggcgacgc cgtcgtctac ggcaactacc cggacatgca cgcccacgtc
    17581 ggcctcgtgg tggaggtcag gtacgaccgg acgggccgca aggccacgca cgtccgcacc
    17641 atcgagggca acttcgacga gcgggtcgtc tactcgaagc tgcgcaagat cgaaggcctg
    17701 aacgccggca agtacctcca ggcgtcgggc ttcgtctcgc ccttctagcg atcaccaccg
    17761 acctcgcccg ataggacttc gaccgatcgg gctccggtcg gtcggaccgc ctcagtcgat
    17821 cggcagcacc cgcccgagga ccgcgaacgg gcgcgggtcc ccggtgaact ggtagtgccg
    17881 cagcacgtcc acgaaaccca tgcgccggta cagccgccac gccttgctcg gcccctccgg
    17941 cgtggacagc agcacgcggg agctgggcac gccctccatc aggttgcgca gcagctgctc
    18001 gccgacgccg cggccctgcg cccgcggcag cacgtgcagc tcggtcagct cgaagtagtc
    18061 gtgcatccac tcctcgaccg cgcgcggccc ggacaccagc gtcagcccgt gccgcacctg
    18121 ctcgtgccac cactggccga ccgagccccg gtagccgtac ccgatcccga tcagctcgtc
    18181 ccgctcgccc aacgccacca cgcaccgcca cccgtcgcgc agcatgtgcg ccaaccacat
    18241 gggcgcgcgc tgctcggccg tgccgggcgg atattccatg gcgctgacgt agagcgcgag
    18301 ggcctcgtcc agccgggagt tcagctcgcg gctggacagc gcgacgaccc gctgggacgg
    18361 cgcggcggtc accgggcgac ctcggcggag gagccaccgg tcaggtcgag caggcccgcg
    18421 taggtcgtcg ggtacaccgc gtgcgggtgc ccggccgctg cccacaccac ctcgtactgc
    18481 tccagcgcga cgtccacgaa cgtcgtgatc ggcgccgggt gccccaccgg ggagacgccg
    18541 ccgatcacct ggccggtgtg ctcgcgcacg aacgccggcg tggcccgctc gatggcgtcc
    18601 gcgcccgcca gcacggcgag tttcgcggtg tcggcgcggt gcgcgccgga ggtgagcacg
    18661 agcagcggcg aggccacgcc gtcgcggacg gcggcgaaga tcaggctgtt ggcgatcgcg
    18721 ccgaccggca cgcccaccgc ctcggccgcg gcggcggcgg tgcggacggc gtcggccaac
    18781 acgcggatcc cgttcgccgc ttcgtggtgg cccgcctcgg acagtgcggc ggccaccttg
    18841 cggatgccgg ggtggtcgag tgcgctcacc tgttcataag accacgggcg gtcggcttga
    18901 ggagttccgg gccggcagga tagtctggtc tggctcgaac atttgttcga gcaatgcctt
    18961 ggtggtgggg cgggggaagc gccccaccac caagtgccgc cgtctccccg cggcggtcgt
    19021 cgctgtcccg acgccgcgag gaggccgcga gatgactcag accttccccc gccgcattcc
    19081 cctcccgcta ccgccggcgt cggcggtgac cctgctcgga caggcccgcg agtgcctggc
    19141 cgaggccgga cgggaccctt cgccgcccac ccgcttcgcc acggcctacc tggccgcgat
    19201 gcgggccgcg gcggccgtgc tggcggccag gggccgaccc caccggggcc gggccaagcc
    19261 gaccagcgtg tgggtcctgc tgccctccct cgcgccggag ctgcgcgagt gggccgcgtt
    19321 cttcgccgag tcctcggcga cgcgcgcggc cgtgctggcg ggcatgacca ggcaggtcac
    19381 ccagcgcgca gccgacgacc tggtgcgcca agcggcgcag ttcaccgagt tggtcgacga
    19441 gatcatgtac gaggacggac tgtgagcagg ggactggtcg cctacgaccg cctgatcgac
    19501 gtagtggagg ccgaagccga gcgcctggcg gcgtcggccg agggacagcg cccggaacgc
    19561 caggtgcccg cgtgccccgg gctcaacctc ggggagaccg cgcgacacgt gggcagcacg
    19621 taccggatgg tgtcgacgtg gctgagggaa ggcagccaac ccctggtgtg gcaacaggac
    19681 ccggagccgg ggcagccgct gccggagtac gtgcgcgcgg gcgtgcgacc gctggtgcgg
    19741 gccctgcggc cgcacgagcc ggacgacccg tgcgagacgt ggtggcccgc cgagcgcaac
    19801 cacaacttct gggcgcggcg gctcgcgcac gagtcgaccg tgcaccggat ggacgtgcag
    19861 gccgcggccg ggctgccgat cgacccggtg gacgacgacg tggccgagga cggcgtggac
    19921 gagatcctca cgctgtggct gggccaccgg ctggacatcc tcggcgtgcg cggcacgcgc
    19981 gaggggacgg tggcgatccg cgccggcgac aaggtgtggc tggccaccac cggcccggac
    20041 ccggcggtgg cccggctcgt caccgacggg gaggcctcgt cggcggccgg cggggtgacc
    20101 ggcaccccca tgcaggtgta ccgctggctg tggggccgca tcccggaccg cgacctgccg
    20161 ccgaccaccg gcgaccacga cgcgatcgcg cagctgtggg ccctgctgag gctggccacc
    20221 aagtagacgc gcgcccgccg tcggacaccg acctcccgtc cggcggcggg cacgccccca
    20281 ccgcggcgct cgcgccccga aaaccgttgc cgcgcacgag cttcacagcg ccagggaggt
    20341 cacttccgac aggccctcgc cggtcgccgt ctccaaccgg aagcggatcg cgcggccgtc
    20401 gatctccagc acgccgaccg agttgccgaa gtgcgggccg ctgagcttgt gccacgacac
    20461 cgggtccggc gagatgcccc gccggtccgc ccaccgccgc agcacccgcg cgatcggctt
    20521 cgaccacgac agccggaacg cgggccggaa cacccacggc gggtcgttgt gcacgggcga
    20581 gcacaccagt tggtacacct tcgcgtccac cgacccggcg aacgcggccc gtgccgcgta
    20641 gctgtggtgc acgtcccccg acagcacgca caccgtgccg ggcgcgtcgt caccccgcga
    20701 gatccgctcc agcaaccggg ccagccgctc gaacgacgcc cggaacgcgg gccagtgctc
    20761 caggtccgcg acctgccgca ccttctcgcc cacccggccg cgccacccgg gcagcccggc
    20821 catccgctcg ttcaacgact ggaagtggct caacccgtgc ggcatcagcc acggcagcga
    20881 cgagccgatg agcaggtggt cgaagtcgcc ctccgcgttg gcctcgatcc agtcgaactc
    20941 ggcgtcaccc accatcaggc gctgcggccc gtccaggatg cgcccgctgc gcgtgtcgat
    21001 caccagcagc cgcacccggc cgaagtcgcg ccggtagctc caccgcgtcg acttgccgcc
    21061 gtcgacctcc cggtccgcct gctcgccgaa gtcctccagc aacgcctgca cgtcaccgcc
    21121 ggtggaccgc accttggcgt acagctcgtc gttcgccagc tcgtccgggc tgaggttgcc
    21181 caggtgctgg tagacccagt acgacgccag gcccgcccgg atgcgctccg gccaccagcg
    21241 cttggcggcc atctgctcgc gccacggccg cgaggtgttc cagtcgtcgc gcacgtcgtg
    21301 gtcgtcgaag atcatcgacg tgggcaccac ggacatcagc cagcggatct cgggatcggc
    21361 ccacgactcg tggtacagct cggcgtactc gcggaacgac accacctcgc ccgcgggctc
    21421 cggtctgcgc tcggccagcc actgcttgat ccgcggcgtc ggctcgtcgg cgtagacctg
    21481 gtcgccgagc agcaccagcg cctccggcca ctgctccggc gactcgtcca ccatccgcag
    21541 cgcgtacgcg tccaaggcgt ccggcccgag cttgtccggc gtgccctccc ccttcgccgc
    21601 gcggcacgac ccgaacagca gccgccgcac cggcgtggtg cggatgcggg gcgccgggaa
    21661 cggcgagtcc ggccgcggcc agaccacctc gccgtccaac cgcacgtcgt agggcgtggt
    21721 cgcgcccggc gccagccctt ccaccaccac cagggcgaag tgctgctcgc cgacctggaa
    21781 cgtctcggcg tgatgccctg ccacggcgac ctcgcacgcc acgtccgtct cgacccacac
    21841 cgtcgccgag gtggagtcga cgtgccgcag caccggaccg agaaccagct gagccattgg
    21901 gcagacgtta ccttcggacc atgccaacga ggtggtgcga tgtggtggtc gactcaaccg
    21961 accccgccgc gctcggccgg ttctggtcgg cgctgctcgg cctgccgatc accggcgagg
    22021 gcgacgacga ggtcgacgtg gcgctcggcg acgggcagga gctggtgttc gggctcgcgc
    22081 cggacgtgaa ggaggtgaag aaccgggtgc acctggacct ggcgtcgaca tcgccggagg
    22141 accaggcggc gatcgtggcg cgggccgtcg cgctgggcgc caaaccggtc gacatcgggc
    22201 agggcgacgt gccgtgggtg gtgctggccg acccggaggg caacgagttc tgcgtgctgg
    22261 agcagcgcga cgagtacgcg cacaccggcc cggtggcggc ggtcgtggtg gacgcgtccg
    22321 acccgccggc gctggccgcg ttctgggccg gtccgaccgg gctgcccgtg acgcgctcgg
    22381 cggccggctt cgcgtcgttg gcgcaggaag ccggtccttc gctggagttc gtgcgagtcg
    22441 ccgagccgaa ggtggtgaag aaccggctgc acctcgacct cgcgccgttc gcggacggcg
    22501 acctgccgac cgaggtggcc cggctggagg cgtggggcgc ggtgcgggtg gacgtggggc
    22561 agatcgacgt gccctggacg gtgctggccg acccggaggg caacgagttc tgcgtcctga
    22621 caccgcgctg accagcgctc aacgccgggc gagcggcgtc tcggccccga cccgggtcag
    22681 cttctccggg ttgcggacgt agtacaggcc ggtgatgcgg gcatcctcga cccggatcgc
    22741 catgacaccg tcgacctcgc cgtcgaagcg cacgacgagc gccgggttgc cgttgaccac
    22801 gacggcctcg ccggtgaacg cgctctcgag ccggcccaga ccgcccagga ccatccggac
    22861 caccttgtcg gccccgacga ccggccgcgg cacggcccgc ttgacaccgc cgccgtcgct
    22921 gaccagcacg acgtccggcg cgagcacggc cagcagaccc ggcacgtccc cgtcctccag
    22981 cgcccgccgc aacgactcca acgccgcccg cgcctcaccc ggcgagaccg cctcgcgcgg
    23041 acggcgggcg tcgacgtgcc ggcgggcgcg gtgcgcgatc tggcggacgg ccgccggggt
    23101 cttgtcgacg gccgcggcga tctcgtcgta gccgacgccg aacgcctccc gcagcacgaa
    23161 gacggcccgc tcggtcggcg acagcgtctc caggacgagc atcagcgcca tcgacacgct
    23221 ctcggccagt tcgacgtcca gggccacgtc cggcgcggtg agcatcggct cgggcagcca
    23281 cgacccgacg taggactcct tgcggcggcg cagcgcgcgc agccggttga gcgcctgccg
    23341 ggtggtgatc cggaccaggt aggcgcgctg gtcgcgcacc tgcgccaagt ccacccgcgc
    23401 ccaccgcaac cagacctcct gcaggacgtc ctcggcgtcg gcggccgagc cgagcatctc
    23461 gtaggcgacg gtgaagagca ggttgcggtg ggccacgaaa gcccccgtcg ccaggtcggc
    23521 gaggtgctcg tccacgtgct cggtccgcgc cacggtgtct ccttc
//
