LOCUS       NZ_CP064192            22208 bp    DNA     circular CON 30-JAN-2024
DEFINITION  Saccharothrix sp. 6-C chromosome, complete genome.
ACCESSION   NZ_CP064192
VERSION     NZ_CP064192.1
KEYWORDS    RefSeq.
SOURCE      Saccharothrix sp. 6-C
  ORGANISM  Saccharothrix sp. 6-C
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharothrix.
REFERENCE   1  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Saccharothrix texasensis strain 6-C
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2020) College of Life Sciences, Chongqing
            University, University Town Road, Chongqing, Chongqing 401331, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 10:20:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,916
            Genes (coding)                    :: 7,819
            CDSs (with protein)               :: 7,819
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 41 of 97
            Pseudo Genes (incomplete)         :: 78 of 97
            Pseudo Genes (internal stop)      :: 6 of 97
            Pseudo Genes (multiple problems)  :: 27 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:34:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 584043
            Orig. end                         :: 606251
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP064192.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22208
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22208
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22208
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12208](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12208
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            680..2134
                     /locus_tag="IOD16_RS02690"
                     /old_locus_tag="IOD16_02685"
     CDS             680..2134
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802887.1"
                     /locus_tag="IOD16_RS02690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02685"
                     /product="serine hydrolase"
                     /protein_id="WP_201438749.1"
                     /transl_table=11
                     /translation="MRSFRRRLLVATALTATTVLVGATAAVPAASAGSDVNALLAESLR
                     QAIVAQNFEDVLDLTPPESVAAASKAGAPEKHDPLSAEEASAARVDAAAARPLHQTPNM
                     DLAVIEIDRLGRPIAMADVLLSPQYPNGVVVPLNTRKLSTDQVRYRWWDDTEWDVNGGR
                     GTRDVLAGREGAPLDFSSPYPASVLKLMVGFGVLRLTDQGRVNLDAVYDYQPVTPHPVC
                     GAASSKVIRQHFDEMITKSQNESTCALIKMIHDLGAWDEVNATFVELGMPTLMVTGTNP
                     ENGGRWIGSNMSSIDTAKLLLLVNGGSGVLWTTDAGRQVTRDELTEASRVQFIKSLGNQ
                     GHNEMLSTTNHCGRAYPVQGIPQLTPPRWIQADGTVKVGDAVYDSDVRPCDAVAEVTFS
                     HKTGWVDTTGSDAGIVRSLPGKERRNYIVVAFSNLGTDYVDTYRPADRPGVFPVLYTEK
                     YAKLGAAVDDIMVAITPMSHWTVRQG"
     gene            2303..3589
                     /gene="hisS"
                     /locus_tag="IOD16_RS02695"
                     /old_locus_tag="IOD16_02690"
     CDS             2303..3589
                     /EC_number="6.1.1.21"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004821 - histidine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006427 - histidyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisS"
                     /inference="COORDINATES: protein motif:HMM:TIGR00442.1"
                     /locus_tag="IOD16_RS02695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02690"
                     /product="histidine--tRNA ligase"
                     /protein_id="WP_201438750.1"
                     /transl_table=11
                     /translation="MSDQPAVRPAPVSGFPEWLPHVRLVELRWLDAIRAAFERYGFCSI
                     ETPAAERLEVLLAKGETSKEVYTLGRAQGSDEGQLGLRFDLTVPFARYAAQHFNELVFP
                     FKRYQVQSVWRGERPQDGRFREFTQCDIDVINVDRVPIHFDAELPRIVHEVLTSLCLPA
                     WTINVNNRKVLQGFYEGLGIDEPLDVIRAVDKIDKIGADGVASLLADRLDQARIESVLA
                     LARLRGGVEDVRALGVRSALLDEGLAELDFVLCELADLPEVVADFSIARGLDYYTGTVY
                     EGKFVDWPEYGSICSGGRYENLAGSFIRRSLPGVGMSIGFSRIFAKVLSAGLLDTGPST
                     PADVLVVLPPDRRRTATATAKALRDNGFNVELYHQEDKVAKQLRYASRKGIPFVWFPPF
                     QDGRSHEVKDLATGAQTTADPATWSRPRP"
     gene            complement(3635..5665)
                     /locus_tag="IOD16_RS02700"
                     /old_locus_tag="IOD16_02695"
     CDS             complement(3635..5665)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012782928.1"
                     /locus_tag="IOD16_RS02700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02695"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_201438751.1"
                     /transl_table=11
                     /translation="MRTAVVTAGVVALIAVLSAVHLTQGTASTGVLDLLAALVGDGDAQ
                     TLAVLEGSRVPRLLAALLLGVALGVAGAGMQSVARNPLASPDTLAVNAGSHLAVVSIAA
                     FGLSLPTLPAGAAAFVGGLAASVIVLGLSGGGSTSPRLVLVGSAVMLTLQSATILLLLM
                     YEQETTGLFAWGSGSLTVSDLDATAQMTPVVVVAVAALLVMGRSLDILALGDDNATVLG
                     LRVRRTRVGAVLLTVALTAAAVTIAGPIGFVGLSAPVITRLLTPIVPGLGKHRALLPFS
                     GLVGVVIVLGADVLLRAVMGSAAAVRVPTGVMTTVLGAVVLIWLARRGRSGGTPRQAPA
                     GRVGVATSSRRLVVTSVVLGVLLVAAPTAGLMLGDRLVLLGDLANWFAGRTGTALTFVV
                     DQRLPRVLAALVAGAALAVAGCGIQSVSRNPLAEPGLLGITAGAGLAAITLITAVPMAG
                     AWHIAGAAGVGAMVAFALVYGLAWRSGLDSDRLVVIGIAMWSAGMALITLLIVTSDPWN
                     TAKALTWMSGSTYGRTLEQVVPTALALVLLTPLLWARHRELDLHSLDEDTPRVLGMRVE
                     RSRLVILLAAGVLAATAVSAIGVVAFVGLVAPHLARSLVGGRHARVLPVAAAVGAVLVS
                     AADTVGRTVIAPAQVPAGLVIALIGTPYFVLVMWRTREVRT"
     gene            complement(5665..6630)
                     /locus_tag="IOD16_RS02705"
                     /old_locus_tag="IOD16_02700"
     CDS             complement(5665..6630)
                     /GO_process="GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666092.1"
                     /locus_tag="IOD16_RS02705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02700"
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_123743839.1"
                     /transl_table=11
                     /translation="MRLLAPALVTAAVLLSACGTTETPTSAPTESAGGPVTVTDSRGKE
                     VKLDSPAQKVVTLEWAETETVASLGVMPVGVADATGYKTWDSAVPLAADVKDVGKRNEP
                     SVDSIVALDPDLVIMAKGRDETLASQLEKYVPVIVTKASDASRNLDRLREDTKLIARAI
                     GKSAEGDALLAELDTALADGKKAVEAKGAAGTPFVMADGWLQGSTVNIRPFGKGSLVSD
                     AAEAVGLKNAWTGEVDPQWGLGATDVEGLTALTDPKTVLFYSASEDDVFTTGLAANPVW
                     QRLPFVVSKKVVKLEPGTWTFGGPKSVIEVAEQFVKATTA"
     gene            complement(6665..7483)
                     /locus_tag="IOD16_RS02710"
                     /old_locus_tag="IOD16_02705"
     CDS             complement(6665..7483)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633963.1"
                     /locus_tag="IOD16_RS02710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02705"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_123743838.1"
                     /transl_table=11
                     /translation="MSKGDALLAGEGLVLAHHDRAVVHGVSLGLRAGAVTALVGPNGSG
                     KSTVLRSLARLHRPREGNVRVGERSVWGHSPLSGKEFARNVTLLTQQRPTPSGVSVRDV
                     VSYGRYPYRTGWRGVDLEGGAAVERAMELTGVTAMADRGVDELSGGELQRVWLASCLAQ
                     QTSVLLLDEPTNHLDLRYQVEVLDVVRDLADDHDVAVGVVLHDLDHAAIIADEVVLLSE
                     GRVVAAGGVRDVLTGEHLTRAYGVTVHVADDPVTGAIHCRPLGRHTPRPA"
     misc_feature    complement(7483..7501)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: strong, score: 32.79"
                     /tool="antismash"
     gene            7656..9329
                     /locus_tag="IOD16_RS02715"
                     /old_locus_tag="IOD16_02710"
     CDS             7656..9329
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015210.4"
                     /locus_tag="IOD16_RS02715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02710"
                     /product="DUF262 domain-containing protein"
                     /protein_id="WP_201438752.1"
                     /transl_table=11
                     /translation="MKKLEAHEVALAKVFSSDYEFVVPDYQRPYTWEPAQATQLLADLV
                     EAVDRDPEDPYFLGSVVLVKRPDEPLAEVIDGQQRLTTLTILLAVLRELTEDPRDADNL
                     DILIWEPGNTILDLDSRPRLRLRPRDEEFFRKHVQARGGVDLLHPEAKYPNDAQARIAA
                     NARALRDALASSTPAQRLALAKAVVQRTFLVMVSTSDLTSAYRIFSVMNSRGVELSPAD
                     IFKSQVIGALPDHDKARYAEKWEDLEADLGREAFADLFSHIRMVVLKYRARQQLLTEFG
                     DHVLKGFLDEGKAAVFVDDVLEPYGSAYRDILTRDHQSLSQATEVNDWLRRLHLLDNFD
                     WQAPALWALKTHRNDGSWLVGFLRRLDRLGAWMLVTRCNAQARGQRIAKLLQELQDGLG
                     LGSPALDLDADERAELRAKLDGDVYRSAAVRKYVLLRLNELVSDPFVAQDVKIVTVEHV
                     LPQSPSAGCEWREVFTESDRERWTHRLANLVLLSRTKNSAAGNLDFAAKRDKYFAGGKS
                     PSYGLTTEVLREETWTPDVLDARQERLVGALAEHWELRVS"
     gene            complement(9322..9777)
                     /locus_tag="IOD16_RS02720"
                     /old_locus_tag="IOD16_02715"
     CDS             complement(9322..9777)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (21-144). E-value:
                     8.3e-13. Score: 40.9. Matches aSDomain:
                     nrpspksdomains_IOD16_RS02720_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022072.4"
                     /locus_tag="IOD16_RS02720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02715"
                     /product="SRPBCC family protein"
                     /protein_id="WP_201438753.1"
                     /transl_table=11
                     /translation="MPRLEPFDVDFFDSAPQRHSYVLDLPVSPERVWRGLTASNPLWWC
                     RLLSSVEYTSPRPFGVGTTRTATVLGVLRLNEHFMRWEEGRRQSFLVDRANLPVYRRFG
                     EDYLVERSGDGCRLTWTFAYEPAVKVDRRMNTVVFRSLVADTRRHFS"
     aSDomain        complement(9346..9714)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IOD16_RS02720_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="8.30E-13"
                     /label="IOD16_RS02720_Polyketide_cyc2.1"
                     /locus_tag="IOD16_RS02720"
                     /protein_end="144"
                     /protein_start="21"
                     /score="40.9"
                     /tool="antismash"
                     /translation="VLDLPVSPERVWRGLTASNPLWWCRLLSSVEYTSPRPFGVGTTRT
                     ATVLGVLRLNEHFMRWEEGRRQSFLVDRANLPVYRRFGEDYLVERSGDGCRLTWTFAYE
                     PAVKVDRRMNTVVFRSLVA"
     gene            10001..12208
                     /locus_tag="IOD16_RS02725"
                     /old_locus_tag="IOD16_02720"
     CDS             10001..12208
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012783597.1"
                     /locus_tag="IOD16_RS02725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02720"
                     /product="germacradienol/geosmin synthase"
                     /protein_id="WP_201438754.1"
                     /sec_met_domain="T1TS (E-value: 3.7e-75, bitscore: 252.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPFQLPDFYMPYPARLNPNLERARTHTKTWAHGMDMIDVPQHG
                     TVIWTEEDLDNHDYALLCAYTHPDASADDLDLVTDWYVWVFYFDDHFVELYKRNPDVTG
                     AKAYLDRLPLFMPVDGAITAEPANPVEKGLADLWTRTVGSHSADWRRRFADNTKHLLDE
                     SMWELLNISEGRLSNPIEYVEMRRKVGGAPWSANLVEHVTGLEVPARIALSRPMGVLRD
                     TFADAVHLRNDLFSYEREVLDEGELSNGVLVLEKFLDLPTQEAAEAVNDLLTSRLHQFE
                     HTAVTEVPLLLDEHAVDPAGRLAVLAYVKGLQDWQSGGHEWHARSSRYMNEGAVTASPV
                     LGGPTGLGTSALRALIATAPQRLRSFSHVPFEEVPPRPEPALDMPFEVAVSPHWHDARE
                     KSVAWAREMGLFDDVPRVWTEGRLRDMDLALCSAGIDPDATPEQLEISALWLTWGTYGD
                     DYYPVVFGRTPDLAVAKAATDRLKQMMPLEGASPSPTTPLERGLADVWQRTTAPMPPDN
                     RRQLRHTLDLMLDSWLWELKNQHENRVPDPVDYVEMRRHTFGSELTMSLSRLGHGKLVP
                     DAIYRTRTIRNIENSAMDYATILNDLFSYRKEIQFEGEVHNMVLVVRNFLDVDLDRAWG
                     IATDLANARLAQFQHSVRVELPALFEEFHLEPEAREALHDYVGELRDWLSGILHWHREV
                     VRYHDADLAKHFGDRELGFTPRALRGPTGLGTASTRLLAAR"
     gene            complement(12467..12697)
                     /locus_tag="IOD16_RS39890"
     CDS             complement(12467..12697)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="IOD16_RS39890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_236594704.1"
                     /transl_table=11
                     /translation="MSQGVAGSLVPAGHMPIVVAAVAPEQRGRAIGYVVTIMTVGGPAG
                     APLGGLVAGAFGRRPVFLMKLPAVAVAVAAR"
     gene            13312..13791
                     /locus_tag="IOD16_RS02735"
                     /old_locus_tag="IOD16_02730"
     CDS             13312..13791
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS02735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_02730"
                     /product="hypothetical protein"
                     /protein_id="WP_201438755.1"
                     /transl_table=11
                     /translation="MDALVALGLVFGFTVVRVGEPEIGSWFQRLGLVFRPGAREKLADL
                     AAKAERAAELHAVLQVRSQNDEREANAVGRLIEALGATETAVIQISSIIVVKADGVIVS
                     KVLTEEQVKHLSHNPDLLKDPRAVLDALKQGFPTDAGGGRAALEAASDRRDVHGE"
     gene            13891..14460
                     /locus_tag="IOD16_RS02740"
                     /old_locus_tag="IOD16_02735"
     CDS             13891..14460
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098571.1"
                     /locus_tag="IOD16_RS02740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02735"
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="WP_236594705.1"
                     /transl_table=11
                     /translation="MIKLAIIVGSTRRGRFAPVVANWFADRAKQRADLSVDVVDLDDLD
                     LPDRLHAFGEDPAPEVALVSPRLRDADAFVVVTPEYNHSFPAPLKSAIDWHYTEWQAKP
                     VGFVSYGGVGGGLRAVEQLRQVFAELHAVTVRDTVSFHGAWSRFDEAGEPVDADEVAKA
                     ATAVLDQVVWWGTALKEARAKRPYGA"
     gene            14462..15442
                     /locus_tag="IOD16_RS02745"
                     /old_locus_tag="IOD16_02740"
     CDS             14462..15442
                     /NRPS_PKS="Domain: PKS_ER (12-321). E-value: 7.7e-34.
                     Score: 109.1. Matches aSDomain:
                     nrpspksdomains_IOD16_RS02745_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098572.1"
                     /locus_tag="IOD16_RS02745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02740"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_201438756.1"
                     /sec_met_domain="ADH_N (E-value: 5e-07, bitscore: 28.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 6.1e-18, bitscore:
                     63.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAVRLHAFGSALRCEEVEDPSPGSGQVRIAVRAAGVHLLDGVVR
                     RGGDGCVPLPDLPAVLGSEVAGVVDAVGRDVDESWLGRRVVTQLGLLGGGYAELAVREV
                     GALHVVPAGLDFPAAVAMICTGSTALGVLDAAAPAPDDVVVVTAAAGGVGTLLVQGAVR
                     AGALVVGLAGCEEKRRAALRAGAAVAVDYLGREWQRQVRERLGGREVTAVLDGVGGVLG
                     RAAADLLAPGGRVVMFGSSSGAPAHLTSADLFARALTATVALGPQVAKRSGGLRALETR
                     ALAVAADHGLTPSIQPFPLADAGRAHEAMESRHTVGKVVLLPAAG"
     aSDomain        14498..15424
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IOD16_RS02745_PKS_ER.1"
                     /evalue="7.70E-34"
                     /label="IOD16_RS02745_PKS_ER.1"
                     /locus_tag="IOD16_RS02745"
                     /protein_end="321"
                     /protein_start="12"
                     /score="109.1"
                     /tool="antismash"
                     /translation="LRCEEVEDPSPGSGQVRIAVRAAGVHLLDGVVRRGGDGCVPLPDL
                     PAVLGSEVAGVVDAVGRDVDESWLGRRVVTQLGLLGGGYAELAVREVGALHVVPAGLDF
                     PAAVAMICTGSTALGVLDAAAPAPDDVVVVTAAAGGVGTLLVQGAVRAGALVVGLAGCE
                     EKRRAALRAGAAVAVDYLGREWQRQVRERLGGREVTAVLDGVGGVLGRAAADLLAPGGR
                     VVMFGSSSGAPAHLTSADLFARALTATVALGPQVAKRSGGLRALETRALAVAADHGLTP
                     SIQPFPLADAGRAHEAMESRHTVGKVVL"
     CDS_motif       14642..14680
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IOD16_RS02745_0001"
                     /evalue="4.70E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="IOD16_RS02745"
                     /protein_end="73"
                     /protein_start="60"
                     /score="10.0"
                     /tool="antismash"
                     /translation="LGSEVAGVVDAVG"
     gene            15453..18317
                     /locus_tag="IOD16_RS40835"
                     /old_locus_tag="IOD16_02750"
     CDS             15453..18317
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098573.1"
                     /locus_tag="IOD16_RS40835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02750"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_268957673.1"
                     /transl_table=11
                     /translation="MLHGRSAELAAVDTLLSAARAGQSGVLVLRGEAGIGKSALLAHAA
                     TRATSPTPELSYPFGTMKSGDPLPGTPAQPPPAPAGTDHRPAAGNQALAGGNQALADGN
                     RAPAGGHRSAADAGFLVLRGTAVESESVVPFAGLNLLLGPVVHRLDALPPNQATALRAA
                     LGLAAPEGGDHHLVGLAVLTLLADLADRNPVLCLVDDAHWLDQGSAQALVFAARRLQAE
                     GIALVFAARDLHAPPFPAPGLPELRLTGLTPEHAAALLEEHAADLPRHVRDQIAEEARG
                     NPLALLELPAAQREGHLPAAHAYRVAALPTHSRIQQTFADRIGTLPERTRTLLLVAAAD
                     DTGDPTVVFEAAGLLGASVDDLEAAEQRQLLRSDDGRLTFRHPLIRAAAYQSAPLKQRL
                     TVHRALADVLPDAHRSAWHLAAATTAPDEDVARALARTAEDARERGGYVAVAAAYQRAA
                     ELTPDPVERGHRLASAAGAAGAAGQFDRAVVLADQAWHLVGNPVDGARVARIQARLASE
                     QGRSAEAAVQLARAVRCAEHTDRELAGELLFHAANNAWAGRDLDLLKDIAARAGDLPGA
                     DDTRRVATAALGLDGADVPGGMAALRELLDSPYVGGPGNAVTAWWNLVLGDDRAAYAWA
                     FDLERQSRAQGALGVLPRALAYLARGRLHLGRHRDARATAEEGLRIAADIGQEFSVGFL
                     SAVLAELAAVEGDAARCEELVATLVDGAPQSVRAACASALLDLGLGRHEAVLDRLADVA
                     AGAHRLYSVTSLPDLVEASARLGKPDANAARWFDEWASGTGRPWARAVSARCRALLTDD
                     ERWYVKAVDLHRVDDSRPFERARTELLYGEWLRRARRKADARTHLRSASEVFERLGATP
                     WAARARTELRATGESRAVPGPDPLSALTPQELQVVRLAAEGLSNRDIGAQLFLSPRTVG
                     YHLYKAYPKLGVASRVELGKLALT"
     gene            complement(18380..19153)
                     /locus_tag="IOD16_RS02760"
                     /old_locus_tag="IOD16_02755"
     CDS             complement(18380..19153)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098575.1"
                     /locus_tag="IOD16_RS02760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02755"
                     /product="hypothetical protein"
                     /protein_id="WP_236594706.1"
                     /transl_table=11
                     /translation="MAATPGTTAAPARAPRPHRPSTPHLLEAEQLVGYLSLPTCPLANN
                     TYKEPDQPNVVRWGSPGDASGWVNQSQCASFLTAVLKRTYKWATPRFFSAHFGVASPFA
                     RDYRAAFAEREIPHFERVTRVADLRPGDVIAIDYRNDQDTNTGHVVMVRSVKGVYTAPT
                     RGLNFRGETQYAVEVVDCTSEPHGVYGVGNYFRFPDNRIFNATAATDGAGYGHMMFYAS
                     DATGEFSRYRWSVNTASARTFPVARRPVSAARVVF"
     gene            complement(19260..19490)
                     /locus_tag="IOD16_RS02765"
                     /old_locus_tag="IOD16_02760"
     CDS             complement(19260..19490)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS02765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_02760"
                     /product="hypothetical protein"
                     /protein_id="WP_201438758.1"
                     /transl_table=11
                     /translation="MLTALARTSEATEWTPLVVVVMIGALTLVMGLTKLLRRVLGMLTR
                     VLLSAGAAMTGIATMLALCTVLTTVLLVYAR"
     misc_feature    complement(19476..19478)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19695..20789
                     /locus_tag="IOD16_RS02770"
                     /old_locus_tag="IOD16_02765"
     CDS             19695..20789
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658121.1"
                     /locus_tag="IOD16_RS02770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_02765"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_201438759.1"
                     /transl_table=11
                     /translation="MVVADDSHSLSHRLRALREEQWPDVVITQSDLAQAFSADKPASVP
                     LLSSWESRGKPKTPPLNRLAAYATFFATERSVATRPYRLIPVDELTPEELRRREELLRE
                     LVALRAAVDREDGTTPAQDRADRGFWYFDDRHDITIVVAQLPADMRAAMPYSDPTQPDY
                     VELYTYADLDALIELHGHIRALNPRSQVNFRIASNLAPDDYTTHLVLLGGVDWNLVTRE
                     LLDRVDLPITQVARHDEAEAGGFVVRDGEGHERLFAPKLGNSRGHEVLIEDVGHFYRGT
                     NPFNHKRTVTICNGQYGRGTLGVVRALTDGRFRDRNAEYLSRRFPDMASYSVLTRVMVV
                     NGQVVTPDWNLPEFRLFEWPEGQS"
     misc_feature    19701..19719
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.37"
                     /tool="antismash"
     gene            20786..22000
                     /locus_tag="IOD16_RS02775"
                     /old_locus_tag="IOD16_02770"
     CDS             20786..22000
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS02775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_02770"
                     /product="hypothetical protein"
                     /protein_id="WP_201438760.1"
                     /transl_table=11
                     /translation="MNVAGPVLAPARVAPAPVGRPRSANHHGSHRHLLTKDAFAVPAEV
                     NAIIVPTARPTRYLEHVVALAGHHRCTLVVLCSHHASAVAATALAERGGVEVVAIDVAD
                     VPRRLLPQFETTAMLRGGRFDRRTDTSLKRNLGLLVAAVSGWERVVYVDDDVVIPRPDD
                     LGTAVGLLDTFTGVGLSVGGYPDNSVVCHAYREAGGDQDTFIGTGALAVGRESFASFFP
                     NIYNEDWFFLLGETGLAPSAVTGQALQKPYDPYRDTMRARTEELGDCLAEGLFGLLDAG
                     RGLTEADAGYWRWFLGRRRRFIEEVIGMVVDTQPDGPAKDRMIAALKAAGGRNRLIEPQ
                     LCVDYLTAWRADREVWRDHVEDACRSHGDRPVPALLTELGLPHHYRPGATTAPETRARY
                     PVVAP"
ORIGIN
        1 gactacgacc ggatctacgc gttcgacgac ctcggctacc gcggtccgcg cttcggctac
       61 gccaccacgc ccgacgagtt caccatggcg aggttccagc agttcgagcg cgccgccggg
      121 cacgcgcccg tgatggcggc gatccccctg ctgtccagcc acgcgccgtg gtcgcccgcg
      181 ccgacggcgg tcggctgggc ggacgtcggc gacggctcgg tgttccactc catggcctcg
      241 ggggaggccc cggcggagga catgttcggc cgcgacccgg cgctcgtgcg gtccgactac
      301 gcgcgcacgg tcgagtactc ggtcaacacc ctggtgtcct acgtcgagac ctacggcgac
      361 gacgacctcg tgctcgtctt cctcggcgac caccagcccg cgccgttcgt caccggcccg
      421 gacgcgggtc gggacgtgcc gatcaccatc gtgacccgcg accgggccgt gctcgaccgg
      481 accgacggct ggggctggac cgacggcctc aagcccgccg cccaagcccc ggtgcgcccc
      541 atgagcactt tccgcgacca gttcctgagc acgttccggt gaccgcttcc ggtgaccgct
      601 tccggtggag cggggcactc atcagcagcg aatgcactac cgtcgtcgcc gcagacggat
      661 caatccatgg gggagtgcaa tgaggtcctt ccgacgcaga ctgctcgtcg ccaccgcgct
      721 caccgccacc acggtgctgg tcggcgccac ggccgcggtg ccggccgcga gcgcgggcag
      781 cgacgtgaac gccctgctgg ccgagtcgct gcggcaggcg atcgtcgcgc agaacttcga
      841 ggacgtgctc gacctgaccc cgccggagtc ggtggcggcg gcgtcgaagg cgggcgcgcc
      901 ggagaagcac gacccgctgt ccgccgagga ggcgtcggcg gcccgggtcg acgccgccgc
      961 ggcccggccg ctgcaccaga cgccgaacat ggacctcgcg gtgatcgaga tcgaccgcct
     1021 cggccggccg atcgcgatgg ccgacgtgct gctcagcccg cagtacccga acggggtcgt
     1081 ggtgcccctg aacacgcgga agctgtccac cgaccaggtg cgctaccgct ggtgggacga
     1141 caccgagtgg gacgtcaacg gcggtcgtgg cacccgtgac gtgctcgccg gccgggaggg
     1201 cgcgcccctc gacttctcct cgccgtaccc cgcgtcggtg ctcaagctca tggtcggctt
     1261 cggcgtgctg cggctgaccg accagggtcg ggtgaacctc gacgcggtct acgactacca
     1321 gccggtcacg ccgcacccgg tgtgcggtgc ggcctccagc aaggtgatcc ggcagcactt
     1381 cgacgagatg atcaccaagt cgcagaacga gtccacctgc gcgttgatca agatgatcca
     1441 cgacctcggc gcgtgggacg aggtcaacgc cacgttcgtc gagctcggca tgccgacgct
     1501 gatggtcacc ggcacgaacc cggagaacgg cggccggtgg atcgggtcga acatgagcag
     1561 catcgacacc gccaagctgc tcctgctggt caacggcggc tcgggcgtgc tgtggacgac
     1621 cgacgcgggc aggcaggtca cccgcgacga gctgaccgag gcgtcccgcg tgcagttcat
     1681 caagtcgctg ggcaaccagg gccacaacga gatgctgtcc accacgaacc actgcgggcg
     1741 cgcctacccg gtgcagggca tcccgcagct gacgccgccg cgctggatcc aggccgacgg
     1801 cacggtgaag gtcggcgacg ccgtctacga cagcgacgtg cggccgtgcg acgcggtcgc
     1861 cgaggtgacg ttcagccaca agacgggctg ggtcgacacg accggcagcg acgcgggcat
     1921 cgtgcggtcc ctgccgggca aggagcggcg caactacatc gtggtcgcct tctccaacct
     1981 gggcaccgac tacgtcgaca cctaccgccc cgccgaccgg cccggtgtct tcccggtgct
     2041 ctacaccgag aagtacgcca agctgggcgc ggccgtcgac gacatcatgg tcgcgatcac
     2101 gccgatgtcc cactggaccg tgcgccaggg ctgacccgcc gcccccgatg cgacaggggt
     2161 tcgaccccgg agtgctcgca ggagcccctg tcgcatcggg ccggccgtgc gcgggcaggg
     2221 cgaccggacc ggacccgctc cggtacaccc gttcgagaaa acccgttggc gcgaccgcgc
     2281 accatccggt gcacttccag ccatgagcga ccagcccgca gtgcgaccgg cgcccgtcag
     2341 cggcttcccg gagtggctgc cgcacgtgcg cctggtggaa ctgcgctggc tggacgcgat
     2401 ccgcgccgct ttcgagcgct acggcttctg ctccatcgaa acccccgccg ccgaacggct
     2461 cgaagtcctc ctcgccaagg gcgagacctc caaggaggtg tacacgctcg gtcgggcgca
     2521 gggttcggac gaggggcagc tcggtctgcg cttcgacctc accgtcccgt tcgcccggta
     2581 cgcggcgcag cacttcaacg agctcgtctt ccccttcaag cgctaccagg tgcagagcgt
     2641 gtggcgtggt gagcggccgc aggacgggcg gttccgcgag ttcacccagt gcgacatcga
     2701 cgtgatcaac gtcgaccggg tgccgatcca cttcgacgcc gagctgccgc gcatcgtgca
     2761 cgaggtgctg acctcgctct gcctgcccgc gtggaccatc aacgtcaaca accgcaaggt
     2821 gttgcagggc ttctacgagg gcttgggcat cgacgagccg ctcgacgtca tccgggccgt
     2881 cgacaagatc gacaagatcg gcgcggacgg cgtggcgtcc ctgctggcgg accggctcga
     2941 ccaggcccgg atcgagtccg tcctggcgct cgcgcgactg cgcggcggcg tcgaggacgt
     3001 gcgcgcgctc ggcgtgcgat cggccctctt ggacgaaggc ctcgcggagc tggacttcgt
     3061 cctctgcgaa ctggccgacc tccccgaggt ggtcgccgac ttctccatcg cccgcgggct
     3121 ggactactac accggcaccg tctacgaggg gaagttcgtc gactggccgg agtacggctc
     3181 gatctgctcc ggcggccggt acgagaacct ggccggctcg ttcatccgcc gcagcctgcc
     3241 cggcgtcggc atgtcgatcg ggttctcccg gatcttcgcc aaggtgctgt ccgccggcct
     3301 gctcgacacg ggcccgagca cgcccgccga cgtcctcgtc gtcctgccgc cggaccgccg
     3361 ccggaccgcc accgccacgg cgaaagcctt gcgcgacaac ggcttcaacg tcgagctgta
     3421 ccaccaggag gacaaggtcg ccaagcagct ccggtacgcc tcccgcaagg gcatcccgtt
     3481 cgtgtggttc ccgccgttcc aggacggccg gtcgcacgag gtgaaggacc tggccaccgg
     3541 cgcgcagacc accgccgacc cggcgacctg gtcacgcccg cgtccctgag ccgggccgcg
     3601 cgaccgcgga ccacgggccg cggtcgcgcc ccgctcaggt ccgcacctcg cgcgtccgcc
     3661 acatcaccag cacgaagtac ggcgtgccga tcaacgcgat caccagcccg gccggcacct
     3721 gcgcgggcgc gatgaccgtc cggcccacgg tgtcggccgc gctcacgagc accgcgccca
     3781 ccgccgccgc gaccggcagc acgcgcgcgt gccgaccgcc gaccagcgac ctggccaggt
     3841 gcggcgcgac cagcccgacg aacgccacca cgccgatcgc ggacacggcc gtcgccgcca
     3901 gcacgcccgc cgccagcagg atcaccagcc gcgaccgctc cacccgcatc cccagcacgc
     3961 gcggcgtgtc ctcgtccagg ctgtgcaggt ccagctcgcg gtgccgcgcc cacagcaacg
     4021 gcgtgagcag caccagcgcc agcgcggtcg gcacgacctg ctccaacgtc cgcccgtacg
     4081 tcgagccgga catccacgtc aacgccttcg ccgtgttcca cgggtccgag gtcacgatca
     4141 gcagcgtgat cagcgccatc ccggccgacc acatcgcgat gccgatgacc accagccggt
     4201 ccgagtccag ccccgaccgc cacgccagcc cgtagaccag cgcgaacgcc accatcgcgc
     4261 ccacgcccgc cgcaccggcg atgtgccacg cgccggccat cggcaccgcc gtgatcagcg
     4321 tgatcgcggc gagccccgca cccgccgtga tgcccagcag gccgggttcc gccaacgggt
     4381 tgcggctcac cgactggatg ccgcacccgg ccaccgccag cgccgcgccc gccaccagcg
     4441 ccgccagcac gcgcggcagc cgctggtcga ccacgaacgt cagggccgtg ccggtccgcc
     4501 ccgcgaacca gttcgccagg tcgcccagca gcaccagccg gtccccgagc atcagccccg
     4561 ccgtcggcgc cgcgaccagc agcacgccca gcaccaccga cgtcaccacg agccgccgcg
     4621 acgacgtggc caccccgacc cgcccggccg gcgcctgccg gggcgtcccg cccgaccgcc
     4681 cccgccgcgc caaccagatc agcacgaccg cgcccagcac cgtggtcatc accccggtcg
     4741 gcacccgcac cgccgccgcc gaacccatga cggcccgcag cagcacgtcc gcgccgagca
     4801 cgatcaccac gccgaccagc ccggagaacg gcagcagcgc ccggtgcttg cccaagccgg
     4861 gcacgatcgg cgtcagcagc cgggtgatca ccggcgcgct cagccccacg aacccgatcg
     4921 gcccggcgat cgtcaccgcc gccgccgtca acgccacggt cagcagcacc gcgcccacgc
     4981 gggtgcgccg caccctcaag cccagcacgg tcgcgttgtc gtcgcccagc gccaggatgt
     5041 cgagcgaccg ccccatcacc agcagcgccg ccaccgcgac caccacgacc ggcgtcatct
     5101 gcgcggtcgc gtccaggtcg ctcacggtca gcgagccgga gccccacgcg aacagcccgg
     5161 tcgtctcctg ctcgtacatc agcagcagca ggatcgtggc cgactggagc gtcaacatga
     5221 ccgccgaccc gacgagcacc aggcgcgggc tggtggaacc gccgcccgac aacccgagca
     5281 cgatcaccga cgccgcgagc ccgccgacga acgccgccgc gcccgccggc agcgtgggca
     5341 ggctcagccc gaacgccgcg atcgacacca cggccaggtg cgagcccgcg ttcacggcga
     5401 gcgtgtccgg ggaggccagc gggttgcgcg ccaccgactg catccccgcg ccggccacgc
     5461 cgagcgcgac gccgagcagc agcgcggcga gcaggcgcgg cacgcgcgag ccctccagca
     5521 cggcgagggt ctgcgcgtcg ccgtcgccca cgagggcggc gagcaggtcg agcacaccgg
     5581 tcgacgcggt gccctgggtg aggtggacgg cggagagcac ggcgatgagc gccacgaccc
     5641 ccgccgtcac gacggcggtg cgcatcaggc ggtggtggcc ttcacgaact gctcggcgac
     5701 ctcgatgacc gacttcggcc cgccgaacgt ccaggtgccc ggctccagct tgacgacctt
     5761 cttcgagacc acgaacggca gccgctgcca caccgggttc gccgcgaggc cggtggtgaa
     5821 cacgtcgtcc tcggaggcgc tgtagaacag caccgtcttc gggtcggtga gcgcggtgag
     5881 gccctcgacg tcggtggcgc ccaggcccca ctgcgggtcg acctcgccgg tccacgcgtt
     5941 cttcaggccg accgcctcgg cggcgtcgga gaccagcgag cccttgccga acgggcggat
     6001 gttgaccgtg ctgccctgca accagccgtc ggccatgacg aacggcgtgc cggccgcgcc
     6061 cttggcctcg accgccttct tgccgtcggc cagcgcggtg tccagctcgg ccagcagcgc
     6121 gtcgccctcg gcggacttgc cgatcgcccg ggcgatcagc ttcgtgtcct cgcgcagccg
     6181 gtcgaggttg cgggaggcgt cgctggcctt ggtgacgatc acggggacgt acttctccag
     6241 ctgggaggcc agcgtctcgt cccggccctt cgccatgatc accaggtcgg ggtcgagcgc
     6301 gacgatcgag tcgacgctgg gctcgttgcg cttgccgacg tccttcacgt cggcggcgag
     6361 cggcacggcc gagtcccacg tcttgtaacc ggtcgcgtcc gcgacaccca ccggcatgac
     6421 acccagtgag gcgacggtct cggtctccgc ccactccagc gtgacgacct tctgggcggg
     6481 ggagtcgagc ttgacctcct tcccgcggga gtcggtgacg gtgaccggac cgccggcgga
     6541 ctcggtcggc gcggacgtcg gcgtctcggt cgtgccgcac gcggacagca gcacggccgc
     6601 cgtgacgagg gcaggggcaa gcaagcgcat cgctggtacc tctcaggggt gaagggggaa
     6661 ggggtcaggc cggtcgcggg gtgtgcctgc cgagggggcg gcagtggatc gcgccggtca
     6721 ccgggtcgtc ggcgacgtgc accgtgacgc cgtaggcccg ggtcaggtgc tcgccggtga
     6781 ggacgtcgcg gaccccgccc gccgcgacga cccggccctc gctcagcagc acgacctcgt
     6841 ccgcgatgat cgccgcgtgg tcgaggtcgt gcagcacgac gccgaccgcc acgtcgtggt
     6901 cgtccgccag gtcgcgcacc acgtcgagca cctcgacctg gtagcgcagg tcgaggtggt
     6961 tggtgggctc gtccagcagc agcacggagg tctgctgcgc caggcacgac gccagccaca
     7021 cgcgctgcaa ctcgccgccg gacagctcgt ccacgccgcg gtcggccatc gcggtcacgc
     7081 cggtcagctc catcgcgcgc tcgacggccg cgccaccctc caggtcgacc ccgcgccacc
     7141 cggtccggta cgggtaccgg ccgtaggaga cgacgtcgcg caccgacacc cccgacggcg
     7201 tcggccgctg ctgggtgagc agggttacgt tgcgggcgaa ctccttgccg gacagggggg
     7261 agtggcccca caccgacctc tcgccgacgc ggacgttccc ctcgcgcggc cggtgcagcc
     7321 gcgccagcga ccgcaggacg gtcgacttgc cggacccgtt gggcccgacg agcgccgtca
     7381 cggcgcccgc gcggagtccg agcgagacac cgtgcaccac cgcgcggtcg tggtgcgcca
     7441 ggaccagtcc ctcaccggcg agcagcgcgt ctcccttaga catgagggga gcctaaccta
     7501 aggtcgcgaa tcgcccatat gggcgtgatc tactgcactc ctcggcctat ccggtaacgc
     7561 tgcgcatggg tgcatcggac gcggatggac ccgtaacggt ggcttcgtcc cgctcgacaa
     7621 ccccgctgtc acacggacgg gacggggtcg gtcaagtgaa gaagctcgaa gcgcacgagg
     7681 tggcgctcgc caaggtgttc tccagcgact acgagttcgt cgtcccggac taccagcgcc
     7741 cctacacctg ggagcccgcg caggcgacgc agctgctggc cgacctggtc gaggcggtcg
     7801 accgggaccc cgaggacccg tacttcctgg ggtccgtggt gctcgtcaag cgcccggacg
     7861 agccgctcgc cgaggtcatc gacggccagc agcggctcac cacgttgacc atcctgctgg
     7921 ccgtgctgcg ggagctgacc gaggacccgc gcgacgcgga caacctcgac atcctcatct
     7981 gggagccggg caacaccatc ctggacctgg actcccgccc gcggctgcgc ctgcgtccga
     8041 gggacgagga gttcttccgc aagcacgtgc aggcgcgagg cggggtcgac ctgctccacc
     8101 cggaggccaa gtaccccaac gacgcgcagg cccgcatcgc cgcgaacgcc cgcgccctgc
     8161 gcgacgccct ggcctcgtcc acgccggccc agcgactggc gctggccaag gccgtggtcc
     8221 agcggacgtt cctggtcatg gtctccacct ccgacctgac cagcgcctac cgcatcttct
     8281 cggtgatgaa ctcgcgcggg gtggagctct caccggccga catcttcaag tcgcaggtca
     8341 tcggggccct gccggaccac gacaaggccc gctacgcgga gaagtgggag gacctggagg
     8401 cggacctcgg gcgcgaggcg ttcgccgacc tgttctcgca catccgcatg gtggtgctga
     8461 agtaccgggc ccggcagcag ttgctcaccg agttcggcga ccacgtcctc aagggcttcc
     8521 tcgacgaggg caaggccgcg gtgttcgtcg acgacgtgct ggagccctac gggtcggcct
     8581 accgggacat cctcacccgc gaccaccagt ccctgtccca ggcgaccgag gtcaacgact
     8641 ggctgcgccg gttgcacctg ctcgacaact tcgactggca ggcgcccgcg ctgtgggcgt
     8701 tgaagacgca ccgcaacgac ggttcctggc tggtcgggtt cctgcgccgg ctcgaccgcc
     8761 tcggcgcgtg gatgctggtg acccgctgca acgcccaggc ccgcggtcag cggatcgcga
     8821 agctcctcca ggagctgcag gatgggctcg gcctgggttc gcccgccctc gacctcgacg
     8881 ccgacgagcg ggccgagctc cgggcgaagc tggacggcga cgtctaccgc agcgccgccg
     8941 tgcggaagta cgtcctgctg cggttgaacg agctggtctc ggacccgttc gtggcgcagg
     9001 acgtcaagat cgtcacggtc gagcacgtgc tgccgcagag cccgtcggcg ggctgcgagt
     9061 ggcgcgaggt cttcaccgag tccgaccggg agcggtggac ccaccggctg gcgaacctcg
     9121 tcctgctcag ccggaccaag aactcggcgg cgggcaacct cgacttcgcc gcgaagaggg
     9181 acaagtactt cgcgggcggc aagtcgccga gctacgggct gaccacggag gtgctgcggg
     9241 aggagacctg gacgcccgac gtgctcgacg cccggcagga gcggctggtc ggcgccctcg
     9301 ccgagcactg ggagctgcgc gtcagctgaa gtggcgccgc gtgtcggcca ccagggacct
     9361 gaacaccacc gtgttcatcc ggcggtcgac cttgaccgcg ggctcgtagg cgaacgtcca
     9421 ggtcagccgg cagccgtcgc cggaccgctc caccaggtag tcctcgccga agcgccggta
     9481 caccggcagg ttcgcccggt ccaccaggaa cgactgccgc cgcccctcct cccagcgcat
     9541 gaagtgctcg ttgagccgca gcacgcccag caccgtcgcg gtccgcgtcg tgcccacgcc
     9601 gaacgggcgc ggggaggtgt actcgaccga cgacagcagc cggcaccacc acagcgggtt
     9661 ggatgcggtc agaccccgcc acacacgttc gggtgacacc ggcaggtcca gcacgtagct
     9721 gtgacgctgc ggcgccgagt cgaagaagtc cacgtcgaac ggctccaagc ggggcacgtc
     9781 gtccagtgtg acgcctgtgc gccggtttca ccgcttgccc gcgcgatggt gcctcaccgg
     9841 ctgaaccgcc acccgccgac gaccacccaa agcagcagtg ggttgagccg gacgggcgga
     9901 ctccccgctc gaacgtgtgg atcaccgccg ccggtcttgg ccgccatgcc cgcgcactgg
     9961 ttgcgtacac ccggtacgtc ccgacgagag gtgcgagccg atggcgcagc cgttccagct
    10021 gccggatttc tacatgccct acccggcccg gctgaacccc aacctggagc gcgcgcgcac
    10081 ccacacgaag acgtgggcgc acgggatgga catgatcgac gtcccccagc acggcacggt
    10141 catctggacc gaggaggacc tcgacaacca cgactacgcc ctgctctgcg cctacaccca
    10201 ccccgacgcc tcggccgacg acctcgacct cgtcaccgac tggtacgtgt gggtcttcta
    10261 cttcgacgac cacttcgtcg agctctacaa gcgcaacccg gacgtgacgg gcgccaaggc
    10321 ctacctcgac cggttgccgc tgttcatgcc ggtcgacggc gcgatcaccg cggaaccggc
    10381 gaacccggtc gagaagggcc tcgccgacct gtggacgcgc accgtcggca gccactcggc
    10441 ggactggcgc cgccggttcg ccgacaacac caagcacctg ctggacgagt ccatgtggga
    10501 gctgctcaac atctccgagg gcaggctctc caacccgatc gagtacgtcg agatgcgccg
    10561 caaggtcggc ggcgcgccgt ggtcggcgaa cctggtcgag cacgtcaccg gcctggaggt
    10621 gcccgcccgg atcgccctca gccgcccgat gggcgtcctg cgcgacacgt tcgccgacgc
    10681 cgtgcacctg cgcaacgacc tgttctccta cgagcgcgag gtgctcgacg agggcgagct
    10741 gagcaacggc gtcctggtgc tggagaagtt cctggacctc ccgacccagg aggccgccga
    10801 ggcggtcaac gacctgctca cctcccgcct gcaccagttc gagcacaccg ccgtcaccga
    10861 ggtgccgctg ctgctcgacg agcacgccgt cgaccccgcc ggccgcctcg ccgtgctggc
    10921 gtacgtgaag ggcctgcagg actggcagtc cggcggccac gagtggcacg cccggtccag
    10981 ccgctacatg aacgagggcg cggtcaccgc gagcccggtg ctcggcggcc ccaccgggct
    11041 gggcacgagc gccctccgcg cgctcatcgc gaccgcgccg caacgcctgc gcagcttcag
    11101 ccacgtgccg ttcgaggagg tgccgccgag gcccgaaccg gcgctggaca tgccgttcga
    11161 ggtggcggtg agcccgcact ggcacgacgc gcgggagaag agcgtcgcct gggcgcgcga
    11221 gatgggcctc ttcgacgacg tgccccgcgt gtggaccgag ggcaggttgc gcgacatgga
    11281 cctcgcgctg tgctcggcgg gcatcgaccc ggacgccacg ccggagcagc tggagatctc
    11341 cgcgttgtgg ctgacctggg gcacctacgg cgacgactac tacccggtcg tgttcggccg
    11401 cacgccggac ctggcggtcg cgaaggccgc caccgaccgg ctcaagcaga tgatgccgct
    11461 ggagggcgcg tcgccgtcgc cgacgacccc gctggaacgc ggcctcgccg acgtctggca
    11521 gcggaccacg gctccgatgc cgccggacaa ccggcggcag ctgcgccaca cgctggacct
    11581 gatgctggac agctggttgt gggagctgaa gaaccagcac gagaaccggg tgcccgatcc
    11641 cgtcgactac gtggagatgc gccggcacac gttcggctcg gagctgacga tgagcctgtc
    11701 ccggctcggc cacggcaagc tggtgcccga cgccatctac cggacccgca cgatacgcaa
    11761 catcgagaac tcggcgatgg actacgccac catcctcaac gacctcttct cgtaccggaa
    11821 ggagatccag ttcgagggcg aggtgcacaa catggtgctg gtggtgcgca acttcctcga
    11881 cgtcgacctg gaccgggcgt ggggcatcgc gaccgacctg gccaacgcgc ggctggcgca
    11941 gttccagcac tcggtgcggg tcgagctgcc cgcgttgttc gaggagttcc acctcgaacc
    12001 cgaggcgcgc gaagcgctgc acgactacgt cggcgagctg cgggactggc tgtcgggcat
    12061 cctgcactgg caccgggagg tcgtgcgcta ccacgacgcc gacctggcca agcacttcgg
    12121 cgaccgggag ctcgggttca cgccgcgggc cctgcgcggc cccacgggcc tcggcacggc
    12181 ctcgacccgc ctcctcgcgg ccaggtgacg tcacacgtcg gaggcggccg ccgggtcgcc
    12241 gccgtgcggg cacggctcca ctcctggcga tgctcggccg ccgcgagcac cccgaccgcc
    12301 accacggcca ccgccgtcgg caccgcgaca ccggcacgga acccggcctc gccgcggccc
    12361 gccagtcccg ccgccagcgc cgccaccgcc ggcccgaccg tcgtgccgac catccgcgcg
    12421 gtcgcgctca gacccgcccc cggtccggca cggcagcccc cgcccgtcac cgcgcagcga
    12481 ccgccaccgc caccgccggc agcttcatca ggaacaccgg acgccggccg aacgcgcccg
    12541 ccaccagccc gcccagcggc gcgccggccg gcccgccgac cgtcatgatc gtgaccacgt
    12601 acccgatcgc ccgcccgcgc tgctccggcg ccaccgccgc gaccacgatc ggcatgtgcc
    12661 cggccggcac cagtgacccg gccacgccct gcgacacccg acccaccacc aagacccaga
    12721 acgacggcgc gaccgtccgc ccggtccacc caccgcccgg ccgggatcgc gaccgccgcc
    12781 atcggcagcg tgtaggccgg cagcacccac gccgcgaccg tcatctcggt ggtgaccacc
    12841 agcatcgccg tcgccaacgc caccacgggc gatcaacggg tcgtgacctg cgcgtcctcc
    12901 gccacggcgg tgacgctacg accgcccgcc gaccggtcga acccgtcagg tgaccggtcg
    12961 ccggacgcgc actcgtgcgg tccgcgcacc gaccggccgc gctatcgtcg aagccccgga
    13021 cacgaggtgg cgacgtgggc gacgacgagc tcggctccga ggcggcggag gactccccgg
    13081 tcgggagcgc cgacgacgag cgggacgagc cggtgtacct cccccccggc gggacgcgcc
    13141 cggctcagcc gcctccgccg gcgcaggcgg cggcaggcgc agcccccggt cgccaggcgg
    13201 gcgggaccgg gcaagcgcgt cgccggcgtc aaggtcacca ggaacccggc gcgaggtccg
    13261 ctggacgggc acgggtcggt ctacctctcc gcggacgacc cccgcgaggt catggacgcg
    13321 ctggtcgcgc tgggactggt gttcggcttc accgtggtgc gcgtcggcga gccggagatc
    13381 ggctcgtggt tccagcggct gggcctggtg ttccgcccgg gagcccggga gaagctcgcc
    13441 gacctcgccg ccaaggccga acgcgcggcc gagctgcacg ccgtcctgca ggtgcgctcg
    13501 cagaacgacg agcgggaggc gaacgcggtc ggccggctga tcgaggcgct cggcgccacc
    13561 gagacggccg tcatccagat cagctccatc atcgtggtca aggcggacgg cgtcatcgtc
    13621 tccaaggtgc tcaccgaaga gcaggtgaag cacctctcgc acaacccgga cctgctcaag
    13681 gacccgcgtg ccgtcctcga cgcgctcaag caggggttcc cgaccgacgc cggcggcggc
    13741 cgcgccgcgc tggaggcggc gtccgaccgc cgcgacgtcc acggcgagtg accggcgcga
    13801 gccgacccgg acgaccagtc acctgacaga tgcccgtgcc ccgcccccgc tcctagcgtc
    13861 gacaccgaca cgacccaggg agggcacacc gtgatcaagc tagcgatcat cgtcggcagc
    13921 acccggcgcg gccggttcgc gccggtggtg gcgaactggt tcgccgaccg ggccaagcag
    13981 cgcgccgacc tgagcgtgga cgtggtcgac ctggacgacc tcgacctgcc ggaccggctg
    14041 cacgccttcg gcgaggaccc ggcgccggag gtcgcgctgg tctcgccgcg cctgcgtgac
    14101 gcggacgcgt tcgtcgtcgt cacacccgag tacaaccaca gcttccccgc gccgttgaag
    14161 agcgccatcg actggcacta caccgagtgg caggccaaac cggtcgggtt cgtctcctac
    14221 ggcggtgtcg gcggcgggtt gcgcgcggtc gagcagcttc ggcaggtctt cgccgagctg
    14281 cacgcggtca ccgtgcggga caccgtcagc ttccacggcg cgtggtcccg gttcgacgag
    14341 gcgggcgagc cggtcgacgc cgacgaggtg gccaaggccg ccacggccgt gctcgaccag
    14401 gtggtctggt gggggacggc gctcaaggag gcccgcgcca agcggcctta cggggcctga
    14461 cgtgcgggcc gtgcggctgc acgcgttcgg ctcggccctg cggtgcgagg aggtcgagga
    14521 cccgtcgccg gggtcgggcc aggtgcggat cgcggtgcgc gcggcgggcg tgcacctgct
    14581 ggacggggtg gtccggcgtg gcggtgacgg gtgcgtgccg ctgccggacc tgcccgcggt
    14641 gctgggttcc gaggtggccg gcgtggtgga cgcggtcggt cgcgacgtgg acgagtcgtg
    14701 gctggggcgg cgggtggtga cgcagctcgg cctgctcggc ggggggtacg ccgagctggc
    14761 ggtgcgggag gtgggcgcgc tgcacgtcgt cccggccggg ctcgacttcc cggcggccgt
    14821 ggcgatgatc tgcaccggga gcacggcgtt gggcgtgctg gacgcggcgg cccccgcccc
    14881 ggacgacgtg gtggtggtga cggccgccgc cggcggggtc ggcaccctgc tggtgcaggg
    14941 cgcggtccgg gcgggcgcgc tggtggtggg cttggcgggg tgcgaggaga agcggcgggc
    15001 cgcgttgcgg gcgggcgcgg cggtggccgt cgactacctg gggcgggagt ggcagcggca
    15061 ggtgcgcgaa cggctcggtg gacgggaggt gacggcggtg ctggacggtg tcgggggtgt
    15121 gctgggccgg gccgccgcgg acctgctcgc gccgggcggg cgggtggtga tgttcggctc
    15181 gtcgtcgggc gcgccggccc acctgacctc ggccgacctg ttcgcccgcg ccctgaccgc
    15241 gaccgtcgcc ctcggaccgc aggtggcgaa gcggtcgggc gggctgcgcg cgctggagac
    15301 ccgcgccctg gccgtcgccg ccgaccacgg gctgaccccg tccatccaac cgttcccgct
    15361 ggccgacgcc gggcgggcgc acgaggcgat ggagagcagg cacacggtcg gcaaggtcgt
    15421 cctgctcccg gccgccggct agggtcgtga ccatgctgca cggcaggtcc gccgaactgg
    15481 ccgcggtgga caccctgctc tccgccgccc gcgccgggca gagcggcgtg ctcgtgctgc
    15541 gcggcgaggc gggcatcggc aagtccgccc tcctggccca cgccgccacc cgggccacct
    15601 cgcccacccc ggaactgtcg taccccttcg gcacaatgaa atcaggggac cccctgccgg
    15661 gtacccctgc gcagccaccg cccgccccgg ccgggaccga ccaccgcccg gccgccggca
    15721 accaagccct ggccggcggc aaccaagccc tggccgacgg caaccgcgcc ccggccggcg
    15781 gacatcgcag cgcggccgac gccgggttcc tggtcctgcg cggcaccgcg gtggagtccg
    15841 agtcggtggt gccgttcgcc gggttgaacc tgctcctcgg ccccgtcgtg caccgcctcg
    15901 acgccctccc gcccaaccag gccaccgcac tgcgcgccgc cctcggcctc gccgcgcccg
    15961 aaggcggcga ccaccacctc gtcggcctgg ccgtgctcac cctcctggcc gacctcgccg
    16021 accgcaaccc cgtcctctgc ctggtcgacg acgcgcactg gctggaccag ggctcggcgc
    16081 aggcgctggt cttcgccgcc cgccgcctcc aggccgaggg catcgcgctg gtcttcgccg
    16141 cccgtgacct gcacgcgccg ccgttccccg cgcccggcct gcccgagctg cgcctcaccg
    16201 gcctcacccc cgagcacgcc gccgccctcc tcgaagagca cgccgccgac ctgccgcgcc
    16261 acgtccgcga ccagatcgcc gaggaagccc gcggcaaccc gttggcgctg ctggaactcc
    16321 ccgccgccca acgcgaaggc cacctgcccg ccgcccacgc ctaccgcgtc gccgccctgc
    16381 ccacccacag ccgcatccag cagaccttcg ccgaccgcat cggcacgctc cccgagcgca
    16441 cccgaaccct cctgctggtc gccgccgccg acgacaccgg cgacccgacc gtcgtgttcg
    16501 aggccgccgg tctgctcggc gcgtccgtcg acgacctcga agccgccgaa caacgccaac
    16561 tcctgcgctc cgacgacggc cggctgacct tccgccaccc cctgatccgc gccgccgcct
    16621 accagagcgc cccgctcaag cagcgcctca ccgtccacag ggcactggcc gacgtgctgc
    16681 ccgacgccca ccgcagcgcc tggcacctgg ccgccgccac caccgcgccc gacgaggacg
    16741 tcgcccgagc cctcgcccgc accgccgagg acgcccgcga gcggggcggt tacgtcgccg
    16801 tcgccgccgc ctaccagcgc gccgccgaac tcaccccgga ccccgtcgaa cgcggccacc
    16861 ggttggcgtc ggcggcgggc gcggccggtg cggcgggcca gttcgaccgc gcggtcgtgc
    16921 tcgccgacca ggcgtggcac ctggtgggca acccggtgga cggcgcgcgg gtcgcccgca
    16981 tccaggcgcg gctggccagt gagcagggac ggtcggcgga ggccgcggtg cagctcgccc
    17041 gcgccgtgcg gtgcgccgag cacacggacc gggaactggc gggggagctg ctgttccacg
    17101 ccgccaacaa cgcgtgggcc ggccgcgacc tggacctgtt gaaagacatc gcggcccgcg
    17161 ccggggacct gcccggcgcc gacgacaccc ggcgggtcgc caccgccgcc ctgggcctgg
    17221 acggcgccga cgtccccggc ggcatggcgg cgttgcgcga actgctcgac tccccgtacg
    17281 tcggcgggcc cggcaacgcg gtcaccgcct ggtggaacct cgtcctcggc gacgaccggg
    17341 cggcctacgc gtgggcgttc gacctggaac gccagtcccg cgcccaaggc gccctcggcg
    17401 tgctgccccg ggccctcgcc tacctggccc gcggccggct gcacctgggc cggcaccgcg
    17461 acgcgcgggc caccgccgag gaggggctgc gcatcgccgc ggacatcggc caggagttca
    17521 gcgtcggctt cctgtccgcc gtgctcgccg agctggccgc cgtcgaaggc gacgcggcca
    17581 ggtgcgagga gctggtggcg acgctggtcg acggcgcgcc ccagtccgtg cgggccgcgt
    17641 gcgcgtcggc gctgctcgac ctcggactcg gccggcacga ggccgtgctg gaccggttgg
    17701 ccgacgtcgc cgcgggcgcg caccggctct actccgtcac cagcctgccc gacctggtcg
    17761 aggcgtccgc ccggctgggc aagccggacg cgaacgccgc ccgctggttc gacgagtggg
    17821 cctcgggcac cggccggccg tgggctcggg ccgtctccgc gcggtgccgc gccctgctca
    17881 ccgacgacga gcggtggtac gtgaaggccg tcgacctgca ccgcgtcgac gacagccgcc
    17941 cgttcgaacg cgcccgcacc gagctgctgt acggggagtg gctgcgccgg gcccgccgca
    18001 aggccgacgc ccgcacccac ctgcggtcgg cgtcggaggt gttcgaacgg ctgggcgcga
    18061 caccgtgggc cgcccgcgcc cgcaccgagc tgcgcgccac cggcgagagc cgggccgtgc
    18121 cgggaccgga cccgctcagc gccctcaccc cgcaggagtt gcaggtcgtg cggctggcgg
    18181 ccgagggact gagcaaccgg gacatcggcg cgcagctgtt cctgagcccg cgcacggtcg
    18241 gttaccacct ctacaaggcg tacccgaagc tcggcgtcgc gtcgcgcgtg gaactcggca
    18301 aactcgccct cacctgaccc gcgcgtgtcc tacgtccaga acacccgtgt cctacgttcg
    18361 gaacacccga gttgaacgct cagaacacga cccgggcggc cgagaccggt cgtcgcgcca
    18421 ccgggaacgt ccgcgcggac gccgtgttca cgctccaccg gtaccggctg aactcgccgg
    18481 tcgcgtcgga cgcgtagaac atcatgtgcc cgtacccggc gccgtccgtc gccgcggtgg
    18541 cgttgaagat ccggttgtcc gggaaccgga agtagttgcc caccccgtac acgccgtgcg
    18601 gctcggacgt gcagtccacg acctccaccg cgtactgcgt ctcgccgcgg aagttcagcc
    18661 cgcgggtcgg cgcggtgtac acgcccttca ccgaacgcac catcaccacg tgaccggtgt
    18721 tggtgtcctg gtcgttgcgg tagtcgatgg cgatcacgtc acccggacga aggtccgcca
    18781 ccctggtgac gcgttcgaag tgcgggatct cccgctccgc gaacgccgcc cggtagtccc
    18841 gcgcgaacgg gctcgccacg ccgaagtggg cgctgaagaa ccgcggcgtc gcccacttgt
    18901 acgtccgctt cagcacggcg gtcaggaacg acgcgcactg gctctggttg acccatccgg
    18961 acgcgtcgcc gggcgaaccc caccggacca cgttcggctg gtccggctcc ttgtaggtgt
    19021 tgttggccaa cgggcacgtc ggcaacgaca ggtagccgac cagctgctcg gcttccagca
    19081 ggtgcggtgt ggacggccgg tgtggacgcg gcgcccgggc cggcgcggcg gtcgtcccgg
    19141 gggtcgcggc cacggcggtt cccccggaga acgatctgcg cgacaggtcc atcgtgcgac
    19201 tcccccttcg atgcgggccc gcacaccgta gtcgaagggg atgagccgca cgtggtggtt
    19261 cagcgcgcgt agaccagcag aacggtggtc agcacggtgc agagggcgag catcgtggcg
    19321 atcccggtca tcgccgcgcc ggccgacagc aggacccggg tgagcatgcc gagcactcgg
    19381 cgcaggagct tggtcagacc catgaccagc gtcaacgcgc cgatcatgac caccaccacg
    19441 agcggcgtcc actcggtggc ctcggaagtt cgggctaacg cggtgagcat gttcatgatg
    19501 acccccggat ggcttcctgg gtgaacttca cctctactca ctgaagttga ctgaacctca
    19561 gtaatatgag agtaagtggg gtgtactcga ctgacaagcc cctgataggg gtatccgctc
    19621 gtcacttttc tccgcaatag tgtatgttcc acgcttcagc tatcacgctg aagttcactg
    19681 aagggcgcgc ggtcgtggtc gttgcggatg actcccactc gctgtcgcac cgccttcggg
    19741 cgctgcgcga ggagcagtgg cccgacgtgg tcatcacgca gagcgacctc gcgcaggcgt
    19801 tcagcgccga caagccggcc agcgtgccgc tgctgtcgtc gtgggagagc cgcggcaagc
    19861 ccaagacgcc accgctgaac cgcctcgccg cctacgccac cttcttcgcc accgagcgct
    19921 ccgtggccac ccgcccgtac cggctgatcc cggtggacga gctgaccccc gaggagctgc
    19981 gccgccgcga ggagctgctg cgcgaactgg tcgcgctgcg cgccgccgtc gaccgcgaag
    20041 acggcacgac ccccgcccag gaccgcgccg accggggctt ctggtacttc gacgaccggc
    20101 acgacatcac catcgtcgtc gcccagctcc cggccgacat gcgggcggcc atgccctact
    20161 ccgaccccac gcagccggac tacgtcgagc tctacaccta cgccgacctc gacgccctca
    20221 tcgagctgca cggccacatc cgcgcgctca acccccgcag ccaggtcaac ttccgcatcg
    20281 cctcgaacct ggcgcccgac gactacacca cgcacctcgt gctgctcggc ggcgtcgact
    20341 ggaacctcgt cacccgcgaa ctgctcgacc gcgtcgacct cccgatcacc caggtcgccc
    20401 ggcacgacga ggccgaagcg ggcggtttcg tggtgcgcga cggcgaaggc cacgagcggc
    20461 tcttcgcgcc caagctcggc aactcccgcg gccacgaggt cctgatcgag gacgtcggcc
    20521 acttctaccg cggcaccaac ccgttcaacc acaagcggac ggtgacgatc tgcaacggcc
    20581 agtacggcag gggcaccctc ggtgtcgtgc gggccctcac cgacggcagg ttccgcgacc
    20641 gcaacgcgga gtacctgagc cggcggttcc cggacatggc ctcttacagc gtcctcacca
    20701 gggtgatggt cgtgaacggc caggtggtca caccggactg gaacctgccg gagttccgcc
    20761 tcttcgaatg gccggagggc cagagttgaa cgtcgcaggc cccgtgctcg cccccgccag
    20821 ggtggccccg gcgccggtcg ggcgtccccg gtcggcgaac caccacggtt cccaccgcca
    20881 cctgctgacc aaggacgcgt tcgccgtccc ggccgaggtg aacgcgatca tcgtgccgac
    20941 cgcgcgaccc accaggtacc tggagcacgt cgtcgcgctc gccggccacc atcgctgcac
    21001 gctggtggtg ctgtgcagcc accacgcgtc ggcggtcgcc gccacggcgc ttgcggaacg
    21061 aggcggtgtc gaggtcgtcg ccatcgacgt cgccgacgtg ccccgcaggc tcctgccgca
    21121 gttcgagacc acggcgatgc tgcgcggcgg tcgattcgac cgccgcaccg acaccagcct
    21181 caagcgcaac ctggggttgc tggtggccgc cgtgtcaggc tgggaacggg tcgtctacgt
    21241 ggacgacgac gtggtgatcc cgcggccgga cgacctgggc accgcggtgg gcctgttgga
    21301 cacgttcacc ggcgtcggcc tctcggtcgg cggctacccc gacaactcgg tggtctgcca
    21361 cgcctaccgt gaggcgggcg gcgaccagga cacgttcatc ggcacgggcg cgctggcagt
    21421 cggccgcgag tcgttcgcct cgttcttccc caacatctac aacgaggact ggttcttcct
    21481 gctcggcgag accgggctcg cgccgtccgc ggtcacgggt caggcgctgc agaagccgta
    21541 cgacccgtac cgggacacca tgcgtgcccg caccgaggag ctgggtgact gcctcgccga
    21601 agggctgttc ggcctgctcg acgccggacg cggcctgacc gaggccgacg ccgggtactg
    21661 gcggtggttc ctgggccgac gtcggcggtt catcgaagag gtcatcggca tggtggtgga
    21721 cacccagccg gacggcccgg ccaaggacag gatgatcgcc gccctcaagg ccgccggtgg
    21781 tcgcaaccgc ctcatcgagc cacagctctg cgtggactac ctcacggcgt ggcgcgccga
    21841 ccgcgaggtg tggcgcgacc acgtcgagga cgcgtgccgc agccacggcg accgtcccgt
    21901 gccggccctg ctgaccgagc tgggtctgcc gcaccactac cgcccgggcg ccaccactgc
    21961 acctgaaacg agggcgcggt acccggtcgt cgctccctga gccaccacaa cgccgccgct
    22021 ggtcaaccga tcaggcgatc cagtcgacga cggacctcca ctgcctcggg tgcgccgagc
    22081 tcaaggtaga tatccagggc gagaccccac cggtcccgag ccctggccac gtcacgcgac
    22141 gcttcgtgtg cgtttgcgaa gccctcgtgc gcctgggcct gctcatggcg atcaccgatg
    22201 tccagggc
//
