LOCUS       NZ_CP064192            22058 bp    DNA     circular CON 30-JAN-2024
DEFINITION  Saccharothrix sp. 6-C chromosome, complete genome.
ACCESSION   NZ_CP064192
VERSION     NZ_CP064192.1
KEYWORDS    RefSeq.
SOURCE      Saccharothrix sp. 6-C
  ORGANISM  Saccharothrix sp. 6-C
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharothrix.
REFERENCE   1  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Saccharothrix texasensis strain 6-C
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9045220)
  AUTHORS   Feng,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2020) College of Life Sciences, Chongqing
            University, University Town Road, Chongqing, Chongqing 401331, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 10:20:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,916
            Genes (coding)                    :: 7,819
            CDSs (with protein)               :: 7,819
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 41 of 97
            Pseudo Genes (incomplete)         :: 78 of 97
            Pseudo Genes (internal stop)      :: 6 of 97
            Pseudo Genes (multiple problems)  :: 27 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:34:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 155126
            Orig. end                         :: 177184
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP064192.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22058
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="1"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22058
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22058
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12058](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12058)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(384..398)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.2"
                     /tool="antismash"
     gene            689..1195
                     /locus_tag="IOD16_RS00745"
                     /old_locus_tag="IOD16_00745"
     CDS             689..1195
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS00745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_00745"
                     /product="hypothetical protein"
                     /protein_id="WP_201438503.1"
                     /transl_table=11
                     /translation="MRAELGVGLPGWVLRASIVVVAAGAAWVLALNGVDWPALALYGAL
                     VLAAAAIPASAAVALIIGYPAAAMVFATDEPSWPGVFVLVVLLHLLHVLSAYAAVLPIG
                     SRIHPVALKAPAKRFVAVQLSVLAFGVVVLLLPGGRTDAAVEVVGLVCAVGLVVGTVLL
                     MRRKG"
     gene            1366..2691
                     /locus_tag="IOD16_RS00750"
                     /old_locus_tag="IOD16_00750"
     CDS             1366..2691
                     /EC_number="1.6.5.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631502.1"
                     /locus_tag="IOD16_RS00750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00750"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_123744150.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 4.1e-47, bitscore:
                     159.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAVKSQPTRIVIVGGGYVGMYTALGLQKKLRSGEASVTVIDPQP
                     HMTYQPFLPEAAAGSIEPRHVVVPLRKVLKRCHVVTGRATRIEHARKAVTVELADGHVE
                     EYEYDVLVSALGAISRTLPIPGLPEVGIGMKTIGEAIYLRNHVLSRLDQAASTNDPELR
                     KRLLSFVVIGGGFAGIETLAELEDMARYALRYYEGLKQSDMHWVLVEATGRIMPEVSAR
                     LGVYTVEQLEKRGIKCYLDTRVKSMEGGHVVLDDGTEFDSDTIIWTAGMKANPMLRDTD
                     LPLDERGRVRCTAAMQVVGLPGVWAAGDCSAVPDLSRTEEDPTATCVPNAQHAIRQSKL
                     LAKNIVASLRGKQPTDYEHKYLGSVAGLGLYKGVADVFGLRFKGVVAWFMHRSYHVMFM
                     PTVNRKFRVFVDWTQALFSGREVVALGQIHEPKAEFDRATKS"
     gene            2886..3008
                     /locus_tag="IOD16_RS40820"
     CDS             2886..3008
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS40820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_267935188.1"
                     /transl_table=11
                     /translation="MSLEELAAQLRRGEIEDRALAEYSAEYATAEKRFCSKKDD"
     gene            3012..4130
                     /locus_tag="IOD16_RS00755"
                     /old_locus_tag="IOD16_00755"
     CDS             3012..4130
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098200.1"
                     /locus_tag="IOD16_RS00755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00755"
                     /product="hypothetical protein"
                     /protein_id="WP_201438504.1"
                     /transl_table=11
                     /translation="MTVSGWGNETVPPPEAARPAKPTPLLLQGQDYLFRSQPKCLDFQE
                     QVHRLGMVDEGDGSPVPCVLVLARAADMEMNELSIALAERGIRMARIDADRSVDLPLTV
                     YTDQPLLELDRWLLRPLLVWRRHFELTALPLEPGTLAGAYAVDQWGAVADWLSSRGDWA
                     HVNPNRNTSHLNRLTQLADASAFGLAVPRTTVTTRPGRTRPGGGRCIVKTSGRHLLEPR
                     PGMQHGLFPRPLETSRAGDVPESAPVIVQEYVPSDTELRVFVVGEQCLAFQVDKLDPAQ
                     LWVDPEAVRVTPVDVPSGLTDRLLALARHWRLQVAAFDLLVSGGDHVFLEVNVNCDWRW
                     FEHRARDSRVSDAVHEWVAARFKELLGAGKGR"
     gene            4111..5181
                     /locus_tag="IOD16_RS00760"
                     /old_locus_tag="IOD16_00760"
     CDS             4111..5181
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098201.1"
                     /locus_tag="IOD16_RS00760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00760"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_201438505.1"
                     /sec_met_domain="PF00881 (E-value: 1.8e-17, bitscore: 62.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAKVAEHATLFYSGGAVVWDDYLHHRQFAISETAELLCRKFTEF
                     TDVDALLAPLAEGDRAALRKVLDELVEAGVLIVEGSPEHERERRLLAAWGDWGASARHF
                     HFASRTLADAPYQRSEEHDAVLDAKLDAQPPPAPFRSLGRTAVLLPRLDGTSKWASAGL
                     LDVLLTRRTSREFGSGPLSLTRVAELLAVLAGPSPARPRIGRSGTVFKTSPSGGGRHPV
                     ELYAHVRGVEALEPGWYHYDGLAHALEPIGVTWGPAEMTAAAGDQDWVGQAPLVLAYTG
                     VLERTRWRYDTSRAYRVVQIDVGHLSQTAYLVATAMGFGIGFTAALRDELVEQALGCDA
                     YHEVVLGLSALGPLPE"
     misc_feature    5170..5172
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     tRNA            5269..5342
                     /anticodon=(pos:160429..160431,aa:Leu,seq:taa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="IOD16_RS00765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="IOD16_00765"
                     /product="tRNA-Leu"
     gene            5269..5342
                     /locus_tag="IOD16_RS00765"
                     /old_locus_tag="IOD16_00765"
     gene            complement(5512..7140)
                     /locus_tag="IOD16_RS00770"
                     /old_locus_tag="IOD16_00770"
     CDS             complement(5512..7140)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005465661.1"
                     /locus_tag="IOD16_RS00770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00770"
                     /product="DUF885 domain-containing protein"
                     /protein_id="WP_201438506.1"
                     /transl_table=11
                     /translation="MGTTAELADELLDLMFSRGPLGATVYGVPGYDHLLADHRAETEES
                     TRARALDIADRARALPADDDPVTRAVVIQQAEAVVDEIDALGVEYTITDSFFAPAGEVL
                     AVMPTTVLSGPESERAYLDRLAAVPDFLRRIAERQLAGAAAGRTPVQHLVDAAVAHLDR
                     YLAADEDPLARPAGSEAFDAERARLLADVVRPAFAAYRDVVAGIQGRPDDRVGLGWLPG
                     GETAYAALTRVQTTTDRTPEELHQTGLDVMAGLAAEYAELGRRVFGTSDVAEVLERMRT
                     DPALRWSTEDELITAAREAVTRAEQAAPRWFGRVPEQRCRVEPVPAADAPGAPIAYYSP
                     PTPDGLRPGTYYANTHRVEERFRYQAEAIAFHEAVPGHHFQITLAQQLTELPVLRRVAH
                     VTAYLEGWGLYTERLADEMGLYSGDVARLGMLAMDSMRAGRLVVDTGLHAHGWSRARAV
                     EYLRENTPLALVEIENEVDRYIAAPGQALAYMVGRLEILRLRAAAEEALGERFDIRAFH
                     DLLLGGGPLPLAVLGEVVAEWIRDR"
     misc_feature    complement(7174..7194)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.35"
                     /tool="antismash"
     misc_feature    complement(7184..7198)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.15"
                     /tool="antismash"
     gene            complement(7194..7841)
                     /locus_tag="IOD16_RS00775"
                     /old_locus_tag="IOD16_00775"
     CDS             complement(7194..7841)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098203.1"
                     /locus_tag="IOD16_RS00775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00775"
                     /product="response regulator transcription factor"
                     /protein_id="WP_123744146.1"
                     /transl_table=11
                     /translation="MRVVLGEDLVLLRDGLIRLLKAYDFDVVEAVDSGPALLKALVDHR
                     PDVAVVDVRLPPTFTDEGLRAAIEARKRVPGLPVLVLSQYVEQLYARELLSDRGGAVGY
                     LLKDRVSDVKQFVSAIRRVAGGGTAMDPEVIDQLLARGARDQPLTTLTPREREVLSLMA
                     EGRSNGAIAGRLFVTEKAVGKHIANIFGKLDLPMSEDDNRRVLAVLAYLDRV"
     gene            complement(7793..9070)
                     /locus_tag="IOD16_RS00780"
                     /old_locus_tag="IOD16_00780"
     CDS             complement(7793..9070)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098204.1"
                     /locus_tag="IOD16_RS00780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00780"
                     /product="sensor histidine kinase"
                     /protein_id="WP_201438507.1"
                     /transl_table=11
                     /translation="MTDHDLVRAARTRLTQAGLGLARTPLCVAGLALIPLQLYTYPLIL
                     VTIGVPLLLVFTALSRHYTGFYRRWASRVLEVEIPAPYRTPANRGPMTRVRTIATDPAT
                     WRDLAFLPVNAIVGVLCGVLPVAFWINGVLGFVMPAIWLDRGDVEYVLVDRDTPGNFVF
                     APLLGIAFLVLAWWATPRAARLHATVARSMLAPGATAALTDRVRVLADSRADTVDAQAA
                     ELRRIERDLHDGAQARLVALGLSLGMAEELLARDPRAAQELLAEARQSSTQALAELRDL
                     VRGIHPPVLADRGLDGALRALALAHPLPVEVDLDLAGRPEAPVESAAYFAVAETLTNVA
                     KHSGATDAWVRVRHDDGRLSLMIGDNGRGGAEPSENGGLRGIERRLAAFDGTLGIASPV
                     GGPTIVTMELPCELSSVKTSSSSGTG"
     gene            complement(9129..10004)
                     /gene="pqqB"
                     /locus_tag="IOD16_RS00785"
                     /old_locus_tag="IOD16_00785"
     CDS             complement(9129..10004)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="IOD16_RS00785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00785"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_201438508.1"
                     /transl_table=11
                     /translation="MRAVVLGTAAGGGVPQWNCACGPCTAVRAGELPARTQDALAVSGN
                     GVDWWLVNASPDIGAQLAATPALAPGPGPRDTPVRGVLFTDAELDHTLGLAVLRGAPGL
                     RVHGPAAVLRALEPTRAVLATYGEWSWRPVAAGRVFALTGGLEVTAFPVSGKRPRYAAG
                     PPAAEHWVVAYRFRDPATGGVLLYAPCLASWPAGFDELVAEADVVLLDGTFYAPSEMGA
                     ATGRPSGQAAMGHLPIAHSLPELRGHPATRRIYTHLNNTNPVLDPASPEHAKITEAGVE
                     VVADGAVIEL"
     gene            complement(10001..11065)
                     /gene="pqqE"
                     /locus_tag="IOD16_RS00790"
                     /old_locus_tag="IOD16_00790"
     CDS             complement(10001..11065)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003079635.1"
                     /locus_tag="IOD16_RS00790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00790"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_201438509.1"
                     /sec_met_domain="PF04055 (E-value: 5.6e-22, bitscore: 77.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 9.7e-10, bitscore:
                     37.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.8e-10, bitscore: 38.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEADAPFGLLAELTHRCPLRCGYCSNPVDLARRDDELDTARWRD
                     VFDQARALGVLQIHLSGGEPLARKDLPELVDHAAGLGCYVNLVTSGLGLTPERLAGLRG
                     VDHVQLSVQDADEAGSNRIAGVRAFEAKLRAAEAVRGAGLPLTVNVVLHRLNLDHVGEI
                     VALAERLGADRLELANTQYYGWALRNRAALLPTEEQLARAGEVVSAAQARSAMEIVYVI
                     ADYHEAHPKPCMHGWGARQLTVAPNGDVLPCPAAGVIDGLGVENVKDRALADIWHTSPA
                     FTAFRGFDWMRDPCRSCARRELDFGGCRCQAFQLTGDASATDPVCTLSPHRGVVDLILA
                     GAPAEVVEHRGVVR"
     gene            complement(11058..11327)
                     /gene="pqqD"
                     /locus_tag="IOD16_RS00795"
                     /old_locus_tag="IOD16_00795"
     CDS             complement(11058..11327)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098207.1"
                     /locus_tag="IOD16_RS00795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00795"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_201438510.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.2e-21, bitscore:
                     75.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.4e-13, bitscore: 47.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGLDAVPRLRRGVKTAYDDTRDSHVVLFPEGVLVLNETAAAVVG
                     LCDGRTSVEGIARRLAEEFDGVEADDVAELVARLVARRVVDVDG"
     aSDomain        complement(11070..11318)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IOD16_RS00795_PqqD_RRE.1"
                     /evalue="4.10E-24"
                     /identifier="RREFam006.1"
                     /label="IOD16_RS00795"
                     /locus_tag="IOD16_RS00795"
                     /protein_end="86"
                     /protein_start="3"
                     /score="75.1"
                     /tool="antismash"
                     /translation="LDAVPRLRRGVKTAYDDTRDSHVVLFPEGVLVLNETAAAVVGLCD
                     GRTSVEGIARRLAEEFDGVEADDVAELVARLVARRVVD"
     gene            complement(11339..12058)
                     /gene="pqqC"
                     /locus_tag="IOD16_RS00800"
                     /old_locus_tag="IOD16_00800"
     CDS             complement(11339..12058)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005464293.1"
                     /locus_tag="IOD16_RS00800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00800"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_201438511.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.8e-82, bitscore:
                     275.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTPETSGATTLTPAEFTARLRALSPRYWDRHPFHLRLHEGRLGK
                     HELQLWAANRWYYQQAIPRKDAAILANCPDVEVRRVWRERIVWHDGGGPGGDRPGEGGV
                     ENWLRLAEAVGLTREEVLDERHVLPGVRFAVDAYVTFARTRPWVEAVASGLTEMFSRGL
                     MARRLVDMREHYPWIAEEGFAYFTARLEVIADDGKSTVDIVVRNCRTREQQEAAVAALA
                     FKCDVLRAVLDAVDYYS"
     gene            complement(12151..12246)
                     /gene="pqqA"
                     /locus_tag="IOD16_RS00805"
                     /old_locus_tag="IOD16_00805"
     CDS             complement(12151..12246)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020387832.1"
                     /locus_tag="IOD16_RS00805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00805"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_123744141.1"
                     /transl_table=11
                     /translation="MSTEPEKRTWVKPDFRDVDTPMEVTAYAARS"
     gene            complement(12325..13488)
                     /locus_tag="IOD16_RS00810"
                     /old_locus_tag="IOD16_00810"
     CDS             complement(12325..13488)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098211.1"
                     /locus_tag="IOD16_RS00810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00810"
                     /product="polysaccharide deacetylase"
                     /protein_id="WP_201438512.1"
                     /transl_table=11
                     /translation="MKRWGWLSTGVALALTLVVLAVLGAREPRPGHDVGDLAAPLPMAP
                     RTTSSSSAATAPAVPASASPPAWMRRMQPGEKPPQFVLFSFDGAASKPHWDRVMPIAKQ
                     VNAHVTGLLSGVYLLPDADADNYTGPGHQAGYSSIGFGGTRADVELRIGYLNAAIDAGH
                     EIGTHYNGHYCVGDEPNVGNWNTEQWNRELDQFFAILEKARQQGFKLDPAAVRGGRTPC
                     LEGQWGQAFPAMRGHGLAYDTSHVSLGVVWPFVHEGLWEFPMPEVRVPALGKQVVMMDF
                     NLWFALNGAKDEPDRAGDYTRIVLDTYRSVHQAALNGNRAPIVIGNHFNEWAGGAFSNA
                     VEGFLGEVCVKPETVCATYTEVIQWMQLQDPVVLEQLRRMPAARNWN"
     misc_feature    complement(13547..13559)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     gene            complement(13556..14263)
                     /locus_tag="IOD16_RS00815"
                     /old_locus_tag="IOD16_00815"
     CDS             complement(13556..14263)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098212.1"
                     /locus_tag="IOD16_RS00815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00815"
                     /product="class F sortase"
                     /protein_id="WP_236594666.1"
                     /transl_table=11
                     /translation="MKALLTGAAVAALLASAALVSTQAPDVVLAGRPVPGDAVVPHPLG
                     DSARSGRGVDLAGMPAGANRPAAPPPATSAATTTAAPPPADPPRQQPGTVRLPEGGLAT
                     LVREEVTAAGALPIPEGIGEATWWGVDLGAAEGATVLAGHVDWKGVTGPFDELWRMAVG
                     QEVTVVDTAGRTFRFRVSRVEAVRKEALPSRAVELFGPRGGHRLVLVTCGGRWVGGDTG
                     YEENQVVTAAPVA"
     gene            complement(14260..15675)
                     /locus_tag="IOD16_RS00820"
                     /old_locus_tag="IOD16_00820"
     CDS             complement(14260..15675)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098213.1"
                     /locus_tag="IOD16_RS00820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00820"
                     /product="hypothetical protein"
                     /protein_id="WP_201438513.1"
                     /transl_table=11
                     /translation="MAWRRLAGAVLAAGLTLLAAPVTAGAQAQEGIGYETDPQGYRGKP
                     AGGDWLGSYLWRGRQVWCVQYSLLAPDSSVEYREGDELLTKGGARLPDDVAGSISYLLL
                     RYSNTQSADESAALAHLLHTWTAREDPARGISLDPNSDFRHIAYNADFHFQQLGRFGQA
                     QQAVGRLEAEAAANRGPWAAKVSAPEKEQVIGTPDTWVVDITKTDGGQVAGAPLNVELT
                     DATLESGAATGELTTSTDGESLAVKVVPTGPNPSFTVKLDSPADRPKVQIPADDNMQRI
                     VTTGGEKKLTANASTTAKTPPGVVKVAKTDAETGKAIAGVALKVTSADGSTPAKRQDDT
                     GLTGPEGTPLVLQTAADGTATVPDLRTPQEVCLIEVAPAKGYEEFFDPNAPPKVCGTVE
                     AGQTLALALTNKPDKPVVPITIPAGSQGAGVVAKAAYTSEVSAGALVGFGGVVLLGAAL
                     VGLLVRRRATSRS"
     gene            15925..16725
                     /locus_tag="IOD16_RS00825"
                     /old_locus_tag="IOD16_00825"
     CDS             15925..16725
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005459152.1"
                     /locus_tag="IOD16_RS00825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00825"
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="WP_123748131.1"
                     /transl_table=11
                     /translation="MRTTSNPAFRNLPTSGGSGNYAGFGQPYEAQQYGGYQGAPPTTGE
                     RPITIDDVVTKTATTLGVAILTGFVSAWLVLSGQVAPFALAVPGMLIGLVLALIIIFKR
                     TPSGPMVLAYSAAEGVFLGAITGVFESIFPGIAWQAILGTFGVFGAMLVVYKTGAIRVT
                     PRLTKWIIGATVGAAVLMLGNLVMGMFGVNMGLRDGGTLAIVFSLVVIGIAAFSFLLDF
                     EAANEMIRGALPAKYAWLAAFGLMTTLVWLYLEILRLLSYFQND"
     gene            complement(16897..17109)
                     /locus_tag="IOD16_RS00830"
                     /old_locus_tag="IOD16_00830"
     CDS             complement(16897..17109)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IOD16_RS00830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IOD16_00830"
                     /product="hypothetical protein"
                     /protein_id="WP_201438514.1"
                     /transl_table=11
                     /translation="MTMPYEWWHSGYDRLCHAFTVHQASEAYFEAACAHSVPPEHVLRS
                     RSGALCVPCLVEVGSAMEDDHTWRG"
     misc_feature    complement(17144..17164)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.83"
                     /tool="antismash"
     gene            complement(17165..18385)
                     /locus_tag="IOD16_RS00835"
                     /old_locus_tag="IOD16_00835"
     CDS             complement(17165..18385)
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466189.1"
                     /locus_tag="IOD16_RS00835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00835"
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_201438515.1"
                     /transl_table=11
                     /translation="MPEAVIVSAARSPIGRAGKGSLKDVRGDDLTVQVLKAALAKVPQL
                     DPHDIDDLMLGCGLPGGEQGFNMGRVVSVLAGYDNVPGTTVTRYCASSVQTTRMALHAI
                     KAGEGDVFISAGVETVSSFARGSSDSWPGTHNPVFAEAGARTAAVAESGASEWVDPRVN
                     GQVPDIYIAMGQTAENLALAKGVTRQEMDEFGVRSQNLAEKAIANGFWAREITPVTLPD
                     GTVVSTDDGPRPGVTIEGVSGLKPVFRPDGRVTAGNCCPLNDGAAALVIMSDVKAKELG
                     ITPLARIVSTGVSGLSPEIMGLGPVEASKRALALAGMSISDIDLVEINEAFAAQVIPSY
                     RDLGIDLDRLNVNGGAIAVGHPFGMTGARITTTLINSLQFHDKQFGLETMCVGGGQGMA
                     MVLERLS"
     gene            complement(18442..19221)
                     /locus_tag="IOD16_RS00840"
                     /old_locus_tag="IOD16_00840"
     CDS             complement(18442..19221)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009944149.1"
                     /locus_tag="IOD16_RS00840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00840"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_201438516.1"
                     /transl_table=11
                     /translation="MRGFRLLALVAGVLGGLTGVAYGLVSEQSRRARVVIGAPEAPPLR
                     ADGVYGDGAGTPVRFAVLGDSMAAGLGVDDPAELPGVVLATGLADEVGAPVRLETHAIS
                     GSTSRDLAAQVDRVVADPPDVALVIIGGNDVTTRLSIPGSAALLGAQVRRLRAAGVGVV
                     VGTCPDLGTVRPIPEPARSVAREWSRRLARAQRVEVERAGGVAVALGDLLAAEFRARHA
                     DYFSRDRFHPSAAGYEAATSVLLAPLCGVLRHEWWPR"
     gene            19320..20690
                     /locus_tag="IOD16_RS00845"
                     /old_locus_tag="IOD16_00845"
     CDS             19320..20690
                     /EC_number="4.2.1.22"
                     /GO_function="GO:0004122 - cystathionine beta-synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019344 - cysteine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229841.1"
                     /locus_tag="IOD16_RS00845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00845"
                     /product="cystathionine beta-synthase"
                     /protein_id="WP_123744135.1"
                     /sec_met_domain="PALP (E-value: 1.3e-67, bitscore: 227.1,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYVESVVDLVGNTPLVKLNAVAEGRRPLILAKVEYLNPGGSVKD
                     RIALRMVEAAERSGELKPGGTIVEPTSGNTGVGLALVAQRKGYKCVFVCPDKVSVDKRN
                     VLKAYGAEVVVCPTAVAPEHPDSYYNVSDRLVAEIPGAWKPNQYANPENPASHYHGTGP
                     EVWRQTDGRITHFVAGVGTGGTISGTGRYLKEVSEGRVKVIGADPEGSVYSGGTGRPYL
                     VEGVGEDFWPDAYDRTVCDEIVAVSDSDSFEITRRLAREEGLLVGGSCGMAVAAALRVA
                     ETAGPDDVIVVLLPDGGRGYLSSVFNDKWMAQYGFLSPDTSGATVGDVLRRKDGTVPDL
                     VHGHPNETVAEAVAIMREYGVSQMPVVNAEPPVMAAEVAGAVNERDLLDALFTGKAQLT
                     DRLDRHMSLKLPTIGAGESISSAMAALSSADGALVLEDGKPAGVVTRQDILGFLAGR"
     gene            20863..21984
                     /locus_tag="IOD16_RS00850"
                     /old_locus_tag="IOD16_00850"
     CDS             20863..21984
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018028.4"
                     /locus_tag="IOD16_RS00850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IOD16_00850"
                     /product="RDD family protein"
                     /protein_id="WP_201438517.1"
                     /transl_table=11
                     /translation="MNAPQPPGNQQFGGHNQQEQGQGAQPSNADATQVVPGGGQPPAFP
                     PPEATQVVPSGPQQVQPNPEATQVVPPGATQQPGSNPYGQPAQQPGSGAFPAQPGSGGF
                     PAQQPPQYGQQPPQQYGQQPPSNPYGQPQQNPYGQQPPSNPYGQPQQNPYGQAPASNPY
                     GQPQQQQQQAWAAQAAYAAQPAYGAPAGGYAEWGSRAVGFLIDYFAPGLIVGVLAGIGA
                     ATGDPTIYLILSGIGYLGLLGFIIYNSWYLAGTTGQSMGKKIAKIKLIKEETGQPIGFG
                     NAFVRHLCHFVDSLPCYAGWFAPLWEAKKQTWADKIMGTIVVNAPEGAAPGGYPGGGYG
                     QPQANPYGQAPASNPYGQPQQQNPYGQQPPQQW"
ORIGIN
        1 cacgacggtc cggcccggcg gcagcctcga cctggccgtg cgggcggcgg cgtcgttggc
       61 ggcgggctac ctgcggcagg gcgaccgggt cgggctggtc gacctcggcc ggccgcagct
      121 cggggcccgg ccgggcgcgg ggcggcggca gctgctgcgg ctgcgcaacc agctcgtggt
      181 gtgcgcgcgg tccgccgggt gggcgcagcg gcccgtgctg cggcccgagc aggtgccgca
      241 cggcgcgctg gtggtggtgc tgtcgccgtt cctggacgcc gaggtggtgg agctggccgt
      301 gcacgccgcg cggcggggca acctggtgct cgcggtggac gtgctgccgt cgcggttgcg
      361 cgccgacccc gggacgccgt ggggtgagag cgcgctcaag gtgatccggt tggagcacga
      421 cgtgcggctg gaggcgatgc ggcagcacgg tgtggccgtg ctgccgtggg gcgcgccgat
      481 cgcgggcgtg ctgcgtgccg cccggaacgc caggcgggtg tcccgatgac gcgagcgttc
      541 aactcggggt gcctgaacgt tggactctcg cgttccgaac gtaggactcg cgcgggagtc
      601 gtaccttcac gccgcgcgtg tcctacgccc ggaacaggcg tgtcctacgt tcggaacacc
      661 cgagttgaac gctcaggacg ggggagcggt gcgcgctgag ctgggcgtgg gcctgccggg
      721 gtgggtgctg cgggcgtcga tcgtggtcgt cgcggccggt gcggcgtggg tcctcgcgct
      781 gaacggggtc gactggcccg cgctcgccct ctacggggcg ctggtcctcg cggcggcggc
      841 gataccggcg tcggccgcgg tcgcgctgat catcggttac ccggcggcgg cgatggtgtt
      901 cgcgaccgac gagccgtcgt ggcccggcgt gttcgtgctg gtcgtgctcc tgcacctgct
      961 gcacgtcctg tccgcctacg ccgccgtcct cccgatcggg tcacgcattc acccggttgc
     1021 cctgaaggcg ccggcgaaga ggttcgtcgc cgtgcaactc tccgtgctcg ccttcggggt
     1081 cgtggtactc ctgttgccgg gcggccgaac ggacgcggcg gtcgaggtcg tcggcctcgt
     1141 ctgcgcggtc gggctggtgg tcggaacggt cctcctgatg cgccggaaag gctgagaaac
     1201 gcaccctccg ggctcagcgc gagctgaccg tctggatcgt tcctctcagc acgttcaccc
     1261 tgccgtgcag gtcagcggct gcgtgtcgcc aatcacgcgg cgactgtggt cacaacgggc
     1321 ccgctcgatg cgccggaaag ccccacccgg tgcgaccatg tgtgtatggc tgctgtgaag
     1381 tcgcaaccca cacggatcgt gatcgtcggc ggtgggtacg tcggcatgta caccgcgctg
     1441 ggcttgcaga agaagctgcg ttccggcgag gcgtccgtca cggtgatcga cccccagccg
     1501 cacatgacct accagccgtt cctccccgag gcggcggccg gttccatcga gccgcgccac
     1561 gtcgtcgtgc cgctgcgcaa ggtcctcaag cggtgccacg tcgtcaccgg ccgcgccacc
     1621 cgcatcgagc acgcgcgcaa ggccgtcacg gtcgagctcg ccgacggcca cgtcgaggag
     1681 tacgagtacg acgtgctcgt ctcggcgctg ggcgcgatct cgcgcacgct gcccatcccg
     1741 ggcctgcccg aggtcggcat cggcatgaag accatcggcg aggccatcta cctgcgcaac
     1801 cacgtgctgt cgcggctcga ccaggccgcc agcacgaacg acccggagct gcgcaagcgg
     1861 ctgctgagct tcgtcgtcat cggcggcggc ttcgcgggca tcgagacgct ggcggagctg
     1921 gaggacatgg cccgctacgc gctgcggtac tacgagggcc tcaagcagtc cgacatgcac
     1981 tgggtgctgg tcgaggccac cggccggatc atgccggagg tgagcgcgcg gctcggcgtc
     2041 tacaccgtcg agcagctcga gaagcgcggc atcaagtgct acctcgacac gcgcgtcaag
     2101 agcatggagg gcggccacgt cgtcctggac gacggcaccg agttcgactc ggacaccatc
     2161 atctggaccg cgggcatgaa ggccaacccg atgctgcgcg acaccgacct gccgctcgac
     2221 gagcgcggcc gggtccggtg cacggcggcg atgcaggtcg tcggcctgcc aggcgtctgg
     2281 gccgcgggcg actgctcggc cgtgccggac ctctcgcgca ccgaggagga cccgacggcg
     2341 acctgcgtgc ccaacgcgca gcacgccatc cggcagtcga agctgctggc caagaacatc
     2401 gtcgccagcc tgcgcggcaa gcagccgacg gactacgagc acaagtacct gggctcggtc
     2461 gccggcctcg gcctctacaa gggtgtggcc gacgtgttcg gcctgcgctt caagggtgtc
     2521 gtcgcctggt tcatgcaccg cagctaccac gtgatgttca tgcccacggt caaccgcaag
     2581 ttccgggtgt tcgtggactg gacgcaggcg ctgttctcgg gtcgcgaggt cgtcgccctc
     2641 ggccagatcc acgagccgaa ggccgagttc gaccgggcca ccaagagctg agcgcgaacg
     2701 gatccgtgcc cgctgcgccg ttcggtcgcg gcgggcgcgg ctccgtccgg agcagtgttc
     2761 tcacttgagc ccccagacgg gctaacgggc cgcgcgtcgc cttgacattg cgtaacgtga
     2821 acccgagaat acagctggtg tatcgcctga atgtgtgatg catcagtggg agagaggtga
     2881 ccgcgatgtc tctcgaggag ctggccgcac agcttcgccg cggtgagatc gaggatcgtg
     2941 cgctggcgga gtactccgcg gagtacgcca ccgccgaaaa gcgtttttgc agcaagaaag
     3001 acgactgagt catgaccgtc tccgggtggg ggaacgagac cgtcccccca cccgaggccg
     3061 ccagaccggc gaaacccacc ccgctgttgc tccaaggcca ggactacctc ttccggtcgc
     3121 aacccaagtg cctggacttc caggagcagg tgcaccgcct cggcatggtg gacgagggcg
     3181 acggcagccc cgtgccctgc gtgctggtcc tcgcccgggc cgccgacatg gagatgaacg
     3241 agctctccat cgcgctcgcc gaacgcggca tccggatggc ccgcatcgac gccgaccgct
     3301 ccgtcgacct gccgctgacc gtctacaccg accagccgct gctggagctc gaccgctggc
     3361 tgctgcgccc gctgctggtg tggcgcaggc acttcgagct gaccgcgctg ccgctggaac
     3421 ccggcacgct ggccggcgcg tacgccgtcg accagtgggg cgcggtcgcc gactggctgt
     3481 ccagccgcgg cgactgggcg cacgtcaacc ccaaccgcaa cacctcgcac ctcaaccggc
     3541 tcacccagct cgcggacgcc tccgccttcg gcctggcggt gccgcgcacc acggtcacca
     3601 cccgaccggg ccgcacccgg cccggcggcg ggcggtgcat cgtcaagacc tccggcaggc
     3661 acctgctgga accgcgcccc ggcatgcagc acggcctgtt cccgcgcccg ctggagacca
     3721 gccgcgccgg tgacgtgccc gagtccgcgc cggtgatcgt gcaggagtac gtgccgtcgg
     3781 acaccgagct gcgcgtgttc gtggtcggcg agcagtgcct ggcgttccag gtcgacaagc
     3841 tcgacccggc gcagctgtgg gtcgaccccg aggcggtccg cgtcacgccc gtcgacgtgc
     3901 cgagcgggct gaccgaccgg ctgctcgcgc tggccaggca ctggcggctc caggtggccg
     3961 cgttcgactt gctcgtctcc ggcggggacc acgtgttcct ggaggtcaac gtcaactgcg
     4021 actggcggtg gttcgagcac cgggcgcggg actcgcgggt gtccgacgcc gtgcacgagt
     4081 gggtggcggc gcgcttcaag gagctgctgg gtgcgggcaa aggtcgctga gcacgcgacg
     4141 ctgttctact ccggcggcgc cgtggtgtgg gacgactacc tgcaccaccg ccagttcgcc
     4201 atcagcgaga ccgccgagct gctgtgccgc aagttcaccg agttcaccga cgtcgacgcg
     4261 ctgctcgcgc cgttggccga gggcgaccgg gcggcgctgc gcaaggtgct ggacgagctg
     4321 gtcgaggccg gcgtgctgat cgtcgagggc tcgcccgagc acgagcggga acggcggctg
     4381 ctcgccgcgt ggggcgactg gggcgcgtcg gcccggcact tccacttcgc cagccgcacg
     4441 ctcgccgacg cgccgtacca gcgctcggag gagcacgacg cggtgctgga cgccaagctc
     4501 gacgcccagc cgccgcccgc gccgttccgc agcctcgggc gcaccgccgt gctgctgccg
     4561 cgcctggacg gcacgtcgaa gtgggcgtcg gcggggctgc tcgacgtgct gctgacccgg
     4621 cgcacgtccc gcgagttcgg gtcggggccg ctgtcgttga cgcgggtcgc cgagctgctg
     4681 gcggtgctgg ccggcccgtc gccggcgcgg ccgcggatcg ggcggtccgg cacggtgttc
     4741 aagaccagcc cgtccggcgg cgggcggcac ccggtggagc tgtacgcgca cgtgcgcggc
     4801 gtcgaggcgc tggagccggg ctggtaccac tacgacgggc tcgcgcacgc gctggagccc
     4861 atcggggtga cgtgggggcc ggccgagatg accgcggcgg cgggggacca ggactgggtc
     4921 gggcaggcgc cgctggtcct cgcgtacacg ggagtactcg aacggactag atggcgttac
     4981 gacacgtcac gtgcttaccg cgttgtgcaa atagacgtag ggcacctgtc ccagacggct
     5041 tatctggttg ctacggcaat gggttttggt atcggcttca ccgcagcatt gcgggatgag
     5101 ctcgtcgaac aagcactcgg ctgtgacgct tatcacgaag tcgtactcgg tctgagcgcc
     5161 ttggggccat tacccgaatg agcgcaatag cggatcgcat tgagccgtgc gggcgacttc
     5221 ttctgaagta gccccacgaa cgctcggtaa ccgcttaggc tccccgctgc ccccgtagcc
     5281 caaccggtag aggcaggctc cttaaaagag tcacagtacg ggttcgaatc ccgtcggggg
     5341 cacgttcggc gccacagaga cctcacccat ctgccgggtg aacccaaaac ggtgcgtcgt
     5401 gccggtcagc ctggagtcac ccgatcgggc cccgcgaacg cgatgcggtt gccgtgaacg
     5461 gcataccgca tcggacgagt cgcgaggtcc gatcggatga ctcgcgcgag ttcagcggtc
     5521 gcggatccat tccgcgacca cttcgcccaa caccgccagc ggcagcggtc cgccgccgag
     5581 cagcaggtcg tggaacgcgc ggatgtcgaa gcgctcgccc agcgcctcct cggccgccgc
     5641 ccgcagccgc aggatctcca gccggccgac catgtaggcc agcgcctggc cgggcgcggc
     5701 gatgtagcgg tcgacctcgt tctcgatctc caccagcgcc agcggcgtgt tctcgcgcag
     5761 gtactcgacg gcccgcgcgc ggctccaccc gtgcgcgtgc aggccggtgt ccaccacgag
     5821 ccgcccggcg cgcatcgagt ccatcgccag catcccgagc cgcgccacgt cgccggagta
     5881 caggcccatc tcgtcggcca gccgctcggt gtagaggccc cagccctcca ggtacgcggt
     5941 gacgtgcgcg acgcggcgca gcaccggcag ctcggtgagc tgctgcgcca gcgtgatctg
     6001 gaagtggtgc cccggcacgg cctcgtggaa cgcgatcgcc tcggcctggt agcggaaccg
     6061 ctcctcgacc cggtgggtgt tcgcgtagta cgtgcccggc cgcagcccgt ccggggtcgg
     6121 cggcgagtag taggcgatcg gcgcgcccgg cgcgtcggcg gcgggcaccg gctcgacccg
     6181 gcagcgctgc tcgggcaccc ggccgaacca gcgcggcgcg gcctgctccg ccctggtcac
     6241 ggcctcgcgg gcggcggtga tcagctcgtc ctcggtgctc cagcgcaggg ccgggtcggt
     6301 gcgcatccgc tccagcacct cggccacgtc ggacgtgccg aacacgcggc ggcccagctc
     6361 ggcgtactcg gcggccaggc cggccatcac gtccaggccg gtctggtgca gctcctcggg
     6421 cgtgcggtcg gtcgtcgtct ggacccgcgt gagcgccgcg tacgccgtct cgccgccggg
     6481 cagccacccc aggcccaccc ggtcgtccgg gcggccctgg atgcccgcca ccacgtcccg
     6541 gtaggcggcg aacgcgggcc gcaccacgtc ggccagcagg cgtgcccgct cggcgtcgaa
     6601 cgcctcgctg cccgccggtc gggccagcgg gtcctcgtcg gccgcgaggt agcggtccag
     6661 gtgcgccacg gcggcgtcca cgaggtgctg gacgggcgtg cggccggccg ccgcgcccgc
     6721 gagctgccgc tcggcgatcc ggcgcaggaa gtcgggcacc gcggcgagcc ggtccaggta
     6781 ggcccgctcg gactcggggc cggacagcac ggtcgtcggc atgaccgcga gcacctcgcc
     6841 cgccggcgcg aagaacgagt cggtgatcgt gtactcgacg cccagcgcgt cgatctcgtc
     6901 cacgaccgcc tcggcctgct ggatgaccac cgcgcgcgtc accgggtcgt cgtccgcggg
     6961 cagagcgcgc gcccggtcgg cgatgtcgag agcccgagcc cgggtggatt cctcggtctc
     7021 cgcccggtgg tcggcgagca ggtggtcgta tcccggcacg ccgtagacgg tcgcgcccaa
     7081 cggcccccgc gagaacatca ggtcgagcag ttcgtcggcc aactccgccg tcgtgcccat
     7141 gcgcaccccc tggtcgtcgt gaaaccaaga tggtacttag cctaagaaac gatttacacc
     7201 cggtccaaat acgccagcac ggcgagcacg cgccggttgt cgtcctcgga catcggcagg
     7261 tccaacttgc cgaagatgtt cgcgatgtgt ttgccgacgg ctttctcggt gacgaacagc
     7321 cggccggcga tcgcgccgtt ggaacggccc tccgccatca gcgacagcac ttcccgctca
     7381 cgcggggtca acgtggtcag cggctggtcc cgcgcgccgc gcgcgagcag ttggtcgatg
     7441 acctcgggat ccatcgcggt gccgccgccg gcgacccggc gaatggcgct cacgaactgc
     7501 ttcacgtccg acacgcggtc cttgagcagg taacccaccg ccccgccccg gtcggacagc
     7561 agttcgcgcg cgtagagctg ctccacgtac tgcgagagca ccaggaccgg caggcccggc
     7621 acccgcttgc gggcctcgat cgcggcgcgc aggccctcgt cggtgaacgt gggcggcagg
     7681 cggacgtcga ccaccgccac gtccgggcgg tggtcgacca gggccttgag cagggcggga
     7741 ccggagtcga ccgcctccac cacgtcgaag tcgtaggcct tcaggagccg gatcagcccg
     7801 tcccggagga ggacgaggtc ttcaccgagg acaactcgca cggcagctcc atggtcacga
     7861 tggtcggccc gcccaccggg ctcgcgatgc cgagtgtgcc gtcgaacgcg gccagccggc
     7921 gctcgatccc gcgcaggccg ccgttctccg acggctccgc gccgccccgc ccgttgtccc
     7981 cgatcatcag cgacaaccgg ccgtcgtcgt gccgcacccg cacccacgcg tcggtcgcgc
     8041 cgctgtgctt ggccacgttc gtcaacgtct cggccaccgc gaagtacgcg gccgactcga
     8101 ccggcgcctc cggccggccc gccaggtcca ggtccacctc caccggcagc gggtgggcca
     8161 gcgccaacgc gcgcagcgcc ccgtccagcc cccggtcggc cagcaccggc gggtggatgc
     8221 cgcgcaccag gtcccgcagc tccgccagcg cctgggtgga ggactggcgc gcctcggcca
     8281 gcagctcctg cgccgcccgc gggtcgcggg ccagcagctc ctcggccatg ccgaggctca
     8341 gcccgagcgc gaccagcctg gcctgcgcgc cgtcgtgcag gtcccgttcg atccggcgca
     8401 gctcggcggc ctgcgcgtcg acggtgtcgg cccgcgagtc ggccagcacg cgcacccggt
     8461 cggtgagggc ggcggtggcg ccgggcgcga gcatcgaccg ggcgacggtc gcgtgcagcc
     8521 gggcggcgcg gggcgtggcc caccacgcca gcaccaggaa ggcgatgccg agcagcggcg
     8581 cgaacacgaa gttgcccggg gtgtcgcggt cgaccagcac gtactcgacg tcgccccggt
     8641 ccagccagat cgccggcatc acgaacccga gcacgccgtt gatccagaac gcgaccggca
     8701 gcacgccgca gaggacgccg acgatcgcgt tgacgggcag gaacgcgagg tcgcgccacg
     8761 tcgccgggtc ggtggcgatg gtgcggaccc tggtcatcgg gccccggttc gccggcgtcc
     8821 ggtacggcgc cgggatctcc acctccagca cccgcgaggc ccagcggcgg tagaagccgg
     8881 tgtagtgacg gctcagcgcg gtgaacacca gcagcagggg cacgccgatg gtcaccagga
     8941 tcagcgggta ggtgtagagc tgcagcggga tcagcgccag gccggccacg cacagcggtg
     9001 tccgggccaa ccccagtcct gcctgcgtca gccgggtacg ggcggcgcgc accaggtcgt
     9061 ggtccgtcat ggcggggatt cttccggctc gccccgggca aatcggtggg tttaaccccc
     9121 caaagcgctc agagctcgat cacggcgccg tccgcgacga cctccacgcc cgcctcggtg
     9181 atcttcgcgt gctccggcga cgccgggtcc agcaccgggt tggtgttgtt gaggtgggtg
     9241 tagatccgcc gggtcgccgg gtgcccgcgc agctccggca ggctgtgcgc gatcggcagg
     9301 tggcccatcg cggcctgccc gctcggcctg ccggtggccg cgcccatctc cgacggcgcg
     9361 tagaaggtgc cgtcgagcag caccacgtcc gcctccgcca ccagctcgtc gaacccggcc
     9421 ggccacgacg ccaggcacgg cgcgtacagc agcaccccgc cggtggccgg gtcgcggaac
     9481 cggtaggcca ccacccagtg ctccgccgcc ggcggcccgg cggcgtagcg cggtcgcttg
     9541 ccgctcaccg ggaacgcggt gacctccagc ccgccggtca gcgcgaacac ccgcccggcc
     9601 gccacgggcc gccacgacca ctcgccgtag gtggccagca cggcacgcgt gggttcgagc
     9661 gcgcgcagca cggccgcggg cccgtgcacc cgcagccccg gcgcgccgcg cagcaccgcc
     9721 aggcccagcg tgtggtcgag ctcggcgtcg gtgaacagca cgccgcgcac gggtgtgtcc
     9781 cgcgggccgg gaccgggcgc gagcgcgggg gtggcggcga gctgcgcgcc gatgtccggt
     9841 gaggcgttga ccagccacca gtccacgccg ttcccgctca ccgccagggc gtcctgcgtg
     9901 cgcgcgggca gctcgccggc ccgcaccgcc gtgcacggcc cgcacgcgca gttccactgc
     9961 ggcacaccgc caccggcggc cgtgccgagc accacggccc tcaccgcacg accccccggt
    10021 gctcgaccac ctcggccggc gcgcccgcga ggatcaggtc gaccacgccc cggtgcggcg
    10081 acagcgtgca caccgggtcg gtcgccgacg cgtcgccggt cagctggaac gcctggcagc
    10141 ggcacccgcc gaagtccagc tcgcggcggg cgcacgaccg gcacgggtcg cgcatccagt
    10201 cgaagccgcg gaaggcggtg aacgcgggcg aggtgtgcca gatgtcggcc agcgcccggt
    10261 ccttcacgtt ctccacgccg agcccgtcga tcacgcccgc cgccgggcac ggcagcacgt
    10321 cgccgttggg cgccacggtc agctgccgcg cgccccaccc gtgcatgcac ggcttcgggt
    10381 gcgcctcgtg gtagtcggcg atcacgtaca cgatctccat cgccgaccgg gcctgcgcgg
    10441 cggacaccac ctcgccggcc cgcgccagct gctcctccgt gggcagcagc gcggcccggt
    10501 tgcgcagcgc ccagccgtag tactgggtgt tggccagctc caaccggtcc gcgcccaggc
    10561 gctcggccag cgcgacgatc tcgccgacgt ggtcgaggtt gagccggtgc agcaccacgt
    10621 tcacggtcag cggcagcccg gcgccccgga ccgcctcggc ggcgcggagc ttggcctcga
    10681 acgccctcac cccggcgatc cggttcgagc cggcctcgtc cgcgtcctgc acggacagct
    10741 gcacgtggtc cacgccgcgc agcccggcca gccgctcggg ggtcaggccg aggccgctcg
    10801 tcaccaggtt cacgtagcag ccgagcccgg ccgcgtggtc gaccagctcc ggcaagtcct
    10861 tgcgcgccag cggttcgccg ccggacaggt ggatctggag cacgcccagc gcgcgcgcct
    10921 ggtcgaagac gtcgcgccac cgcgcggtgt ccagctcgtc gtcgcggcgg gccaggtcga
    10981 ccgggttgga gcagtacccg cagcgcagcg ggcaccggtg ggtcagctcg gcgagcaggc
    11041 cgaacggcgc gtccgcctca cccatcgacg tccaccaccc ggcgcgccac cagccgtgcg
    11101 acgagctcgg ccacgtcgtc cgcctccacc ccgtcgaact cctcggccag ccggcgcgcg
    11161 atgccctcga cggacgtgcg cccgtcgcac agcccgacca ccgccgccgc ggtctcgttg
    11221 agcaccagca cgccttccgg gaacagcacc acgtggctgt cccgggtgtc gtcgtaggcc
    11281 gtcttcacgc cccggcgcag gcgcggcacc gcgtccaaac ccgtcatggc aggctccgtc
    11341 atgagtagta gtccacggcg tccagcaccg ctcgcagcac gtcgcacttg aacgccagcg
    11401 cggcgaccgc cgcctcctgc tgctcgcgcg tgcggcagtt gcgcaccacg atgtccacag
    11461 tggacttccc gtcgtcggcg atcacctcga gccgggcggt gaagtaggcg aagccctcct
    11521 cggcgatcca cgggtagtgc tcgcgcatgt ccaccagccg gcgcgccatc aggccgcggg
    11581 agaacatctc ggtcagcccg gacgccaccg cctccaccca cggcctggtg cgggcgaacg
    11641 tcacgtaggc gtccaccgcg aaccgcacgc ccggcagcac gtgccgctcg tcgagcacct
    11701 cctcgcgggt cagcccgacg gcctcggcca ggcgcagcca gttctccacc ccgccttctc
    11761 cgggtcggtc cccgccgggc ccgccgccgt cgtgccagac gatccgctcc cgccacaccc
    11821 gccggacctc gacgtccggg cagttggcca ggatcgccgc gtccttgcgc ggtatcgcct
    11881 gctggtagta ccagcggttg gccgcccaca gctgcagctc gtgcttgccc agccggccct
    11941 cgtgcagccg gaggtggaag gggtggcggt cccagtagcg gggtgacagg gcgcgcaggc
    12001 gcgcggtgaa ctcggccggc gtcaacgtcg tggcgccgga cgtctcgggg gtgggcacag
    12061 cggtggggca cctctcgggt acgcgggcgc cgcgccccgc cgacgcgcgg ccggcggacc
    12121 cggcggcggg cgggacgcga cgtggcgggc tcagctgcga gcggcgtaag cggtgacttc
    12181 catgggggtg tcgacgtccc ggaaatcggg cttgacccag gtgcgcttct cgggctcggt
    12241 gctcatgcgc tctactcctc ggatgcgtgg tgcttctccg tggggcggcg gtaacccacc
    12301 gtagagcttg cggcggctac cgcgctagtt ccagttccgt gcggcgggca tgcgcctcaa
    12361 ctgttccagc accaccggat cctgcaactg catccactgg atcacctctg tataggtggc
    12421 gcacaccgtt tcgggcttga cacacacctc gccgaggaac ccctccaccg cgttgctgaa
    12481 cgcgccgccc gcccactcgt tgaagtggtt gccgatcacg atcggcgcgc ggttgccgtt
    12541 gagcgcggcc tggtgcaccg agcggtacgt gtccagcacg atccgggtgt agtcgccggc
    12601 ccggtccggc tcgtccttgg cgccgttgag cgcgaaccag aggttgaagt ccatcatcac
    12661 gacctgcttg cccagcgcgg gcacgcggac ctccggcatg gggaactccc acaggccctc
    12721 gtgcacgaac ggccacacca cgccgaggct cacgtggctg gtgtcgtagg ccaggccgtg
    12781 gcctcgcatg gccgggaacg cctggcccca ctgcccctcc aggcacggcg tgcgcccgcc
    12841 gcgcacggcc gccgggtcca gcttgaaccc ctgctgccgc gccttctcca ggatcgcgaa
    12901 gaactggtcg agctcccggt tccactgctc ggtgttccag ttgccgacgt tcggctcgtc
    12961 gccgacgcag tagtggccgt tgtagtgcgt gccgatctcg tgccccgcgt cgatggccgc
    13021 gttgaggtag ccgatccgca gctcgacgtc cgcgcgggtg ccgccgaacc cgatggacga
    13081 gtagcccgcc tggtgccccg ggccggtgta gttgtcggcg tcggcgtccg gcagcaggta
    13141 gacacccgac agcaggccgg tgacgtgcgc gttcacctgc ttggcgatcg gcatgacccg
    13201 gtcccagtgc ggcttggacg cggcgccgtc gaacgagaac agcacgaact gcggcggttt
    13261 ctcgccgggc tgcatgcgcc gcatccacgc gggcggcgag gccgaggcgg gcacggcggg
    13321 cgcggtggcg gcgctgctgc tgctggtcgt gcgcggcgcc atcggcagcg gtgcggccag
    13381 gtcgcccacg tcgtgccccg gtctgggctc acgggctccc aggacggcca gcaccaccag
    13441 ggtgagtgcc agcgcgacgc ccgtgctcag ccagccccat cgcttcacac ccccaagacg
    13501 acgggaagta gccggaggtt gcctcgcggt gacgcgacta ccacccgtga ccgggtcacg
    13561 ccaccggagc ggcggtcacg acctggttct cctcgtagcc ggtgtcgccg ccgacccacc
    13621 gcccgccgca cgtcaccagc accagccggt gcccgccgcg cgggccgaac agctccaccg
    13681 cccgggacgg cagggcctcc ttgcggaccg cctcgacccg gctcacccgg aaccggaagg
    13741 tccggccggc cgtgtcgacc acggtcacct cctgcccgac cgccatccgc cacagctcgt
    13801 cgaacggccc ggtcacgccc ttccagtcca cgtgcccggc cagcacggtc gcgccctcgg
    13861 ccgcgccgag gtcgacgccc caccacgtcg cctcgccgat gccctccggg atcggcagcg
    13921 cgccggccgc ggtgacctcc tcgcgcacca gcgtggccag cccgccctcg ggcagccgca
    13981 ccgtccccgg ctgctgccgg ggcgggtcgg cgggcggggg agccgcggtg gtcgtcgcgg
    14041 cgctcgtcgc gggcggtggc gccgcgggcc ggttcgcgcc ggccggcatg ccagccaggt
    14101 ccacaccgcg tcccgagcgc gcgctgtcgc ccaacgggtg cggcacgacg gcgtcaccgg
    14161 ggacgggccg gcccgcgagc accacgtccg gcgcctgggt ggagacgagc gcggcggagg
    14221 cgagcagagc cgccaccgcc gcgccggtca gcagtgcctt cacgaccgcg aggtcgcccg
    14281 tcgccggacc aggagaccga ccagcgccgc gccgagcagc accacgccgc cgaacccgac
    14341 cagcgccccg gccgacacct cgctggtgta cgcggccttc gcgaccacgc cggcgccctg
    14401 ggacccggcg gggatcgtga tcgggacgac cggcttgtcc ggcttgttgg tcagcgccag
    14461 cgccagcgtc tggcccgctt cgacggtccc gcacaccttg ggcggcgcgt tggggtcgaa
    14521 gaactcctcg tagcccttgg ccggcgcgac ctcgatcagg cagacctcct gcggcgtgcg
    14581 caggtcgggc acggtcgcgg tgccgtcggc ggcggtctgg agcaccagcg gcgtgccctc
    14641 gggcccggtc agcccggtgt cgtcctgccg cttcgcgggc gtcgagccgt cggccgaggt
    14701 caccttcagc gccacgcccg cgatcgcctt gccggtctcg gcgtcggtct tggcgacctt
    14761 caccacgccc ggcggggtct tcgcggtcgt cgacgcgttc gcggtcagct tcttctcgcc
    14821 gcccgtggtg acgatccgct gcatgttgtc gtcggccggg atctgcacct tgggccggtc
    14881 ggcggggctg tccagcttca ccgtgaacga cgggttgggc ccggtcggca ccaccttcac
    14941 cgccagcgac tcgccgtccg tggacgtggt cagctcaccg gtcgcggcgc cggactccag
    15001 cgtcgcgtcg gtcagctcca cgttcagcgg cgcgccggcc acctggccgc cgtcggtctt
    15061 ggtgatgtcc accacccacg tgtcgggggt gccgatgacc tgctccttct ccggagcgct
    15121 caccttcgcc gcccacgggc cgcggttggc cgccgcctcc gcctccagcc ggcccaccgc
    15181 ctgctgggcc tggccgaagc gcccgagctg ctggaagtgg aagtcggcgt tgtaggcgat
    15241 gtgccggaag tcgctgttcg ggtcgaggga gatgccccgg gccgggtcct cgcgcgccgt
    15301 ccacgtgtgc agcaggtgcg ccagcgccgc cgactcgtca gccgactggg tgttcgagta
    15361 cctcaacagg aggtacgaga tgctgcccgc cacgtcgtcg ggcagccgcg cgccgccctt
    15421 ggtgagcagc tcgtcgcctt cccggtactc gacggagctg tccggggcga gcagcgagta
    15481 ctgcacgcac cacacctgcc ggccgcgcca gaggtacgag ccgagccagt ccccgcccgc
    15541 gggcttgccg cggtaaccct gcgggtcggt ctcgtagccg atgccctcct gcgcctgcgc
    15601 cccggctgtc acgggcgccg ccagcagcgt cagaccggcc gcgagcaccg cgccggcgag
    15661 tcgtctccaa gccatgatgt cctgaacccc tcgggcgcgc cggtgggcgt cgccggtcgg
    15721 tgagagctgc cggcactgag ccttacgggt ccgagatcac gtcgacaagc caccagcggg
    15781 gtggaacgcc gactacgctc cgcagcgcgg ggtgtggatt cgagatcgac agtccgagta
    15841 aagtcgcttt tacccgacgg gaaccgatcg actcgtgtgg tcgttgaacc ccgtgacggc
    15901 gtcagcacgc cacaggagga cgaggtgcgt accaccagca accccgcgtt ccgcaacctg
    15961 ccgaccagcg gcggtagcgg taactacgca ggcttcggcc agccctacga ggcgcagcag
    16021 tacggcggct accagggcgc gccgcccacc accggcgagc ggcccatcac gatcgacgac
    16081 gtggtcacca agaccgcgac gacgctcggt gtggccatcc tcaccgggtt cgtctcggcg
    16141 tggctggtgc tctccggcca ggtcgcgccg ttcgcgctcg cggtgcccgg catgctcatc
    16201 gggctggtcc tggccctgat catcatcttc aagcgcacgc cgagcggccc gatggtgctg
    16261 gcctactcgg cagcggaggg cgtgttcctc ggcgccatca ccggcgtgtt cgagtcgatc
    16321 ttcccgggca tcgcctggca ggcgatcctg ggcacgttcg gcgtgttcgg cgcgatgctc
    16381 gtggtctaca agacgggcgc gatccgcgtc accccgcgcc tgaccaagtg gatcatcggc
    16441 gcgaccgtcg gcgcggccgt gctcatgctc ggcaacctgg tcatgggcat gttcggcgtg
    16501 aacatgggcc tgcgtgacgg cggcaccctg gcgatcgtct tcagcctggt ggtcatcggc
    16561 atcgcggcgt tcagcttcct gctggacttc gaggcggcca acgagatgat ccgcggcgcg
    16621 ctgcccgcca agtacgcctg gctcgccgcg ttcggcctga tgaccacgct ggtctggctg
    16681 tacctggaga tcctgcgcct gctgtcgtac ttccagaacg actagtcgca cccgcacccg
    16741 aagggcgccc ccggccaccg ccgggcggcg cccttcgcgc tctccacccc accgcgtgag
    16801 tcctacctcc agcacgcgcg agtcctacgt tcggaacacg tgtgtcctac gttcggaaca
    16861 cccgagttga acactcggac gcgcccggtc gggcgttcag ccgcgccagg tgtggtcgtc
    16921 ctccatcgcc gaaccgacct cgaccaggca cggcacgcac aacgccccgc tccgcgaccg
    16981 cagcacgtgc tccggcggca cggagtgggc gcacgccgcc tcgaagtacg cctccgaggc
    17041 ctggtgcacg gtgaaggcgt ggcacagccg gtcgtacccg ctgtgccacc actcgtacgg
    17101 catcgtcacc ccgacctccc ctgctcaaag gtaggacgag gggtaacagt aatcgtgacg
    17161 cggttcagct caaccgttcg aggaccatcg ccatgccctg gccgccgccg acgcacatgg
    17221 tctccaggcc gaactgcttg tcgtggaact gcagcgagtt gatcagcgtc gtggtgatcc
    17281 gcgcgccggt catcccgaac gggtgaccca cggcgatcgc gccgccgttg acgttgagcc
    17341 ggtccaggtc gatgcccagg tcgcggtagg acgggatgac ctgcgccgcg aacgcctcgt
    17401 tgatctccac caggtcgatg tccgagatcg acatcccggc cagcgccagc gcccgcttcg
    17461 acgcctccac cggcccgagc cccatgatct ccggcgacag cccggacacg ccggtcgaca
    17521 cgatccgcgc cagcggcgtg atgcccagct ccttcgcctt cacgtcgctc atgatcacga
    17581 gcgccgccgc gccgtcgttc aacgggcagc agttgcccgc cgtcacgcgc ccgtccggcc
    17641 ggaacaccgg cttgagcccc gacacgccct cgatcgtcac gccgggtcgc gggccgtcgt
    17701 cggtggacac gaccgtgccg tccggcagcg tcaccggcgt gatctcgcgc gcccagaagc
    17761 cgttggcgat ggccttctcg gcgaggttct gcgaccgcac gccgaactcg tccatctcct
    17821 gccgcgtcac gcccttggcc agcgcgaggt tctccgcggt ctggcccatg gcgatgtaga
    17881 tgtcgggcac ctgcccgttc acccgcgggt cgacccactc cgacgccccg gactccgcca
    17941 cggccgccgt gcgggccccg gcctcggcga acaccgggtt gtgcgtgccg ggccacgagt
    18001 cggacgaccc gcgcgcgaag ctcgacacgg tctccacgcc ggcgctgatg aagacgtcgc
    18061 cctcgccggc cttgatcgcg tgcagcgcca tccgggtcgt ctgcacgctc gacgcgcagt
    18121 accgggtcac ggtggtgccc ggcacgttgt cgtacccggc cagcaccgac accacgcggc
    18181 ccatgttgaa gccctgctcg ccgccgggca ggccgcagcc gagcatgagg tcgtcgatgt
    18241 cgtgggggtc gagctgcggg accttcgcca gcgcggcctt gaggacctgc acggtcaggt
    18301 cgtcgccacg cacgtccttg agcgagccct tgcccgcgcg cccgatgggc gaccgggcgg
    18361 cggagacgat cacggcctca ggcattacgg aactcctttg tttcgccgca acgtgtgacg
    18421 tgcagcctag ttaacgcccg ttcagcgcgg ccaccactcg tgacgaagga cgccgcacaa
    18481 cggcgccagc aggaccgacg tcgccgcctc gtacccggcc gcgctcgggt ggaaccggtc
    18541 ccggctgaag tagtcggcgt gccgcgcccg gaactccgcc gcgagcaggt cgcccagcgc
    18601 caccgccacg ccgcccgccc gttccacctc gacccgctgc gcccgcgcca gccgccgcga
    18661 ccactcccgc gccaccgacc gcgctggctc cgggatcggc cgcaccgtgc ccaggtcggg
    18721 gcacgtgccg acgaccacac ccacccccgc cgcgcgcagc cgccgcacct gcgcgcccag
    18781 caacgccgcc gaccccggga tggacagccg cgtggtcacg tcgttcccgc cgatgatcac
    18841 cagcgccacg tccggcgggt cggccaccac ccggtccacc tgcgccgcca ggtcgcgcga
    18901 cgtggacccg gagatcgcgt gcgtctccag ccgcacgggc gcgcccacct cgtcggccaa
    18961 ccccgtcgcg agcaccacgc ccggcagctc ggccgggtcg tccaccccga gcccggccgc
    19021 catcgagtcg cccagcacgg cgaaccgcac gggcgtcccg gcgccgtccc cgtagacgcc
    19081 gtcggcgcgc aacggcggcg cctcgggcgc gccgatcacc acccgcgccc gccgcgactg
    19141 ctcgctgacc agcccgtacg ccaccccggt caacccgccc aacacccccg cgaccagcgc
    19201 gaggagccga aacccccgca tcggaccctc cactctcccg atgcccatcg tccaccgggc
    19261 cgaacccacc gccacccata tacgctcagc gagtcatctc aagaagtgga aggtccgtcg
    19321 tggagtacgt cgagagcgtc gtagacctgg tcggcaacac gccgctggtg aagctgaacg
    19381 cggtggccga gggccgccgg ccgctcatcc tcgccaaggt cgagtacctc aaccccggcg
    19441 gcagcgtgaa ggaccgcatc gcgctgcgca tggtcgaggc ggccgagcgc agcggcgagc
    19501 tcaagcccgg cggcacgatc gtcgagccca cctcgggcaa caccggcgtc ggcctggcgc
    19561 tcgtggccca gcggaagggc tacaagtgcg tcttcgtctg cccggacaag gtcagcgtgg
    19621 acaagcgcaa cgtgctcaag gcctacggcg ccgaggtcgt ggtgtgcccg acggcggtcg
    19681 cgccggagca ccccgactcc tactacaacg tctccgaccg cctggtcgcc gagatccccg
    19741 gcgcgtggaa gcccaaccag tacgccaacc cggagaaccc ggccagccac taccacggca
    19801 ccggcccgga ggtgtggcgg cagaccgacg gccggatcac gcacttcgtc gcgggcgtcg
    19861 gcaccggcgg caccatctcg ggcacgggca ggtacctcaa ggaggtctcc gagggccggg
    19921 tgaaggtcat cggcgcggac cccgagggct cggtctactc cggcggcacc ggccggccgt
    19981 acctggtgga gggcgtcggc gaggacttct ggccggacgc ctacgaccgg accgtgtgcg
    20041 acgagatcgt cgcggtgagc gacagcgact cgttcgagat cacccggcgg ctggcccgcg
    20101 aggaagggct gctcgtcggc ggctcgtgcg gcatggcggt cgcggcggcg ctgcgggtcg
    20161 ccgagaccgc gggcccggac gacgtgatcg tggtgctgct gcccgacggc gggcgcggct
    20221 acctgtcgag cgtgttcaac gacaagtgga tggcgcagta cggcttcctg tcgcccgaca
    20281 cctccggcgc gacggtcggc gacgtgctgc gccgcaagga cggcacggtg cccgacctcg
    20341 tgcacggcca tccgaacgag acggtcgccg aggcggtcgc gatcatgcgc gagtacggcg
    20401 tctcccagat gccggtcgtc aacgccgagc cgccggtgat ggccgccgag gtggcgggcg
    20461 cggtcaacga gcgggacctg ctcgacgcgc tgttcaccgg caaggcgcag ctgaccgacc
    20521 ggctcgatcg gcacatgtcg ttgaagctgc ccacgatcgg cgcgggcgag tcgatcagct
    20581 cggccatggc ggcactgtcc tcagcggacg gtgcgctggt gctcgaggac ggcaagccgg
    20641 ccggagtcgt cacccggcag gacatcctgg gtttcctcgc cggtcgctga ccggacgccc
    20701 gccggacgcc gattccccgt cggaccgctg tcgacgtgtc ccgatcctca tcgcggatcg
    20761 ggacaggttg accggttgtg cgtggccggg gggatcgcat ccgctagcgt tggccaccga
    20821 ctcatacacc tacggcccgt gccaaggggg ttggaaactc cgatgaacgc tccgcagccg
    20881 ccaggaaacc agcagttcgg cggtcacaac cagcaggagc aggggcaggg tgcccagccc
    20941 tcgaacgccg acgcgaccca ggtcgtgccc ggcggcggcc agccccctgc tttcccgccg
    21001 ccggaggcga cccaggtcgt gccctccgga ccgcagcagg tccagccgaa cccggaggcg
    21061 acccaggtcg tgccgccggg cgcgacgcag cagcccgggt ccaacccgta cggtcagccg
    21121 gcgcagcagc ccggttccgg cgcgttcccg gcccagcccg gttccggcgg gttcccggcg
    21181 cagcagccgc cccagtacgg ccagcagccg ccgcagcagt acggccagca gccgccgtcg
    21241 aacccgtacg gtcagccgca gcagaacccg tacggccagc agccgccgtc caacccgtac
    21301 ggtcagccgc agcagaaccc gtacggccag gcgcccgcgt cgaacccgta cggccagccg
    21361 cagcagcaac agcagcaggc gtgggccgcg caggccgcgt acgccgcgca gcccgcttac
    21421 ggcgcgcccg ccggcggtta cgcggagtgg ggcagccgcg cggtcggctt cctcatcgac
    21481 tacttcgcgc ccggcctgat cgtcggcgtc ctggccggca tcggcgcggc caccggcgac
    21541 ccgacgatct acctgatcct cagcggcatc ggctacctgg gcctgctcgg tttcatcatc
    21601 tacaactcct ggtacctggc cggcaccacc ggccagtcga tgggcaagaa gatcgcgaag
    21661 atcaagctca tcaaggagga gacggggcag ccgatcggtt tcggcaacgc cttcgtgcgc
    21721 cacctgtgcc acttcgtcga ctcgctgccc tgctacgcgg gctggttcgc gccgctgtgg
    21781 gaagcgaaga agcagacgtg ggccgacaag atcatgggca ccatcgtggt caacgccccc
    21841 gagggcgcgg ctcccggcgg ctaccccggc ggcggctacg gccagccgca ggccaacccg
    21901 tacggccagg cgcccgcgtc gaacccgtac ggccagccgc agcagcagaa cccgtacggc
    21961 cagcagccgc cgcagcagtg gtgacctagg tcggacaccg gttcacccga ttcacccgac
    22021 cgcccgtcgg ccttccggtc gacgggcggt tgcttttt
//
