GCF_016526145.1 - 31 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JADDUE010000010.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene	31,197	55,872
Region 1.2	ranthipeptide	124,326	145,869

NZ_JADDUE010000011.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	hglE-KS	226,391	255,217

NZ_JADDUE010000012.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	amglyccycl	111,742	132,938	Low	cetoniacytone A	other:cyclitol

NZ_JADDUE010000013.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	redox-cofactor	19,375	42,157
Region 4.2	redox-cofactor	71,802	93,882

NZ_JADDUE010000015.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	lanthipeptide-class-i	93,370	118,167

NZ_JADDUE010000016.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	NRPS-like	1	26,276

NZ_JADDUE010000018.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	NI-siderophore	1	33,523	Low	schizokinen	NRPS:Type IV

NZ_JADDUE010000019.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	lassopeptide	11,864	34,317	Medium	ulleungdin	ribosomal:unmodified

NZ_JADDUE010000001.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	ectoine	534,090	544,479	High	ectoine	other:other

NZ_JADDUE010000020.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	lanthipeptide-class-i	16,305	40,893	Medium	planosporicin	ribosomal:RiPP:Lanthipeptide

NZ_JADDUE010000021.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	betalactone	5,882	34,535

NZ_JADDUE010000023.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	terpene-precursor	1	17,292

NZ_JADDUE010000002.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	RiPP-like	287,765	298,577
Region 21.2	betalactone	489,517	519,931

NZ_JADDUE010000003.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 28.1	terpene	108,060	134,127	Low	hopene	terpene
Region 28.2	terpene	148,002	170,254	High	geosmin	terpene:Sesquiterpene
Region 28.3	terpene	392,988	414,199

NZ_JADDUE010000004.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 29.1	T1PKS	36,907	83,359
Region 29.2	indole	358,538	381,825	Low	borregomycin A/borregomycin B/borregomycin C/borregomycin D	other:other
Region 29.3	RiPP-like	412,977	424,218

NZ_JADDUE010000005.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 30.1	hydroxytropolone	76,813	103,046
Region 30.2	terpene	224,741	245,751	Medium	isorenieratene	terpene

NZ_JADDUE010000006.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 31.1	terpene-precursor	1,252	22,277
Region 31.2	NRP-metallophore,NRPS	28,509	79,852	Low	marformycin A/marformycin B/marformycin C/marformycin D/marformycin E/marformycin F	NRPS:Type I

NZ_JADDUE010000007.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 32.1	terpene-precursor	69,288	90,364	Low	isorenieratene	terpene
Region 32.2	CDPS	367,601	384,845

NZ_JADDUE010000008.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 33.1	arylpolyene	147,547	188,707
Region 33.2	redox-cofactor	348,175	361,677	Low	lankacidin C	NRPS:Type I+PKS

NZ_JADDUE010000009.1 (Saccharopolyspora sp. HNM0986)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 34.1	amglyccycl	155,800	176,975	Low	pyralomicin 1a	NRPS:Type I+PKS:Type I

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene	31,197	55,872
Region 1.2	ranthipeptide	124,326	145,869
Region 2.1	hglE-KS	226,391	255,217
Region 3.1	amglyccycl	111,742	132,938	Low	cetoniacytone A	other:cyclitol
Region 4.1	redox-cofactor	19,375	42,157
Region 4.2	redox-cofactor	71,802	93,882
Region 6.1	lanthipeptide-class-i	93,370	118,167
Region 7.1	NRPS-like	1	26,276
Region 9.1	NI-siderophore	1	33,523	Low	schizokinen	NRPS:Type IV
Region 10.1	lassopeptide	11,864	34,317	Medium	ulleungdin	ribosomal:unmodified
Region 11.1	ectoine	534,090	544,479	High	ectoine	other:other
Region 12.1	lanthipeptide-class-i	16,305	40,893	Medium	planosporicin	ribosomal:RiPP:Lanthipeptide
Region 13.1	betalactone	5,882	34,535
Region 15.1	terpene-precursor	1	17,292
Region 21.1	RiPP-like	287,765	298,577
Region 21.2	betalactone	489,517	519,931
Region 28.1	terpene	108,060	134,127	Low	hopene	terpene
Region 28.2	terpene	148,002	170,254	High	geosmin	terpene:Sesquiterpene
Region 28.3	terpene	392,988	414,199
Region 29.1	T1PKS	36,907	83,359
Region 29.2	indole	358,538	381,825	Low	borregomycin A/borregomycin B/borregomycin C/borregomycin D	other:other
Region 29.3	RiPP-like	412,977	424,218
Region 30.1	hydroxytropolone	76,813	103,046
Region 30.2	terpene	224,741	245,751	Medium	isorenieratene	terpene
Region 31.1	terpene-precursor	1,252	22,277
Region 31.2	NRP-metallophore,NRPS	28,509	79,852	Low	marformycin A/marformycin B/marformycin C/marformycin D/marformycin E/marformycin F	NRPS:Type I
Region 32.1	terpene-precursor	69,288	90,364	Low	isorenieratene	terpene
Region 32.2	CDPS	367,601	384,845
Region 33.1	arylpolyene	147,547	188,707
Region 33.2	redox-cofactor	348,175	361,677	Low	lankacidin C	NRPS:Type I+PKS
Region 34.1	amglyccycl	155,800	176,975	Low	pyralomicin 1a	NRPS:Type I+PKS:Type I

No secondary metabolite regions were found in these records:: NZ_JADDUE010000014.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000017.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000022.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000024.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000025.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000026.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000027.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000028.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000029.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000030.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000031.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000032.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000033.1 (Saccharopolyspora sp. HNM0986); NZ_JADDUE010000034.1 (Saccharopolyspora sp. HNM0986)

Compact view

NZ_JADDUE010000010.1 - Region 1 - terpene

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Location: 31,197 - 55,872 nt. (total: 24,676 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

INP57_RS21970: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: transketolase

INP57_RS21980: transketolase

smcogs: SMCOG1204: transketolase

Hydrolases: hydrolase

INP57_RS21900: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Lyases: cyclase

INP57_RS21925: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Isomerases: racemase

INP57_RS21885: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Ligases: synthase synthetase

INP57_RS21905: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

INP57_RS21935: pseudouridine synthase

smcogs: SMCOG1279: pseudouridine synthase

INP57_RS21975: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001201.3	0.57	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0000677.5	0.52	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000844.5	0.50	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0000675.5	0.48	terpene	(+)-T-muurolol	Streptomyces clavuligerus ATCC 27064
BGC0002127.3	0.48	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0002309.2	0.47	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0002283.2	0.47	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.47	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0001910.4	0.47	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001201.3	0.57	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0000677.5	0.52	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000844.5	0.50	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0000675.5	0.48	terpene	(+)-T-muurolol	Streptomyces clavuligerus ATCC 27064
BGC0002127.3	0.48	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0002309.2	0.47	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0002283.2	0.47	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.47	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0001910.4	0.47	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

INP57_RS21905: PT_FPPS_like

Domain 1 (56 - 363): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

INP57_RS21925: T1TS

Domain 1 (23 - 340): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.57 out of 26.33

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.07 out of 25.31

Confidence: medium

Additional weak hits (8):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.70 out of 20.97

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.58 out of 27.55

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.64 out of 18.57

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.04 out of 33.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.11 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.47 out of 28.19

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.58 out of 20.01

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CatR	H2O2-responsive repressor

NZ_JADDUE010000010.1 - Region 2 - ranthipeptide

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Location: 124,326 - 145,869 nt. (total: 21,544 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

INP57_RS22300: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

INP57_RS22325: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

INP57_RS22330: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: halogenase

INP57_RS22315: halogenase

smcogs: SMCOG1119: halogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000906.3	0.42	other (other)	heme D1	Heliophilum fasciatum
BGC0002493.3	0.41	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0000706.3	0.40	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002218.2	0.39	terpene	(-)-Cyatha-3,12-diene	Dentipellis sp. KUC8613
BGC0000275.4	0.36	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000252.5	0.36	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0000880.4	0.36	other (nucleoside)	tunicamycin B1	Streptomyces chartreusis NRRL 3882
BGC0001444.5	0.36	other (shikimate-derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0002473.3	0.35	NRPS	propanochelin, butanochelin, pentanochelin	Acinetobacter bouvetii DSM 14964 = CIP 107468

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000906.3	0.42	other (other)	heme D1	Heliophilum fasciatum
BGC0002493.3	0.41	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0000706.3	0.40	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002218.2	0.39	terpene	(-)-Cyatha-3,12-diene	Dentipellis sp. KUC8613
BGC0000275.4	0.36	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000252.5	0.36	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0000880.4	0.36	other (nucleoside)	tunicamycin B1	Streptomyces chartreusis NRRL 3882
BGC0001444.5	0.36	other (shikimate-derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0002473.3	0.35	NRPS	propanochelin, butanochelin, pentanochelin	Acinetobacter bouvetii DSM 14964 = CIP 107468

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (7):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.43 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.35 out of 32.74

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.43 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.58 out of 29.38

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.69 out of 30.98

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.84 out of 29.65

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Mycofactocin_RRE; Location: 19 - 97; Score: 91.8

TFBS definitions

Regulator	Description

NZ_JADDUE010000011.1 - Region 1 - hglE-KS

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Location: 226,391 - 255,217 nt. (total: 28,827 nt) Show pHMM detection rules used

Region on contig edge.

hglE-KS: (hglE or hglD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acylase

INP57_RS24080: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

INP57_RS24085: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Lyases: dehydratase

INP57_RS24070: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000863.3	0.50	other (other)	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0002648.2	0.50	PKS	eicosapentaenoic acid	Shewanella sp. N2AIL
BGC0000861.5	0.50	other (other)	eicosapentaenoic acid	Shewanella sp. BR-2
BGC0000056.3	0.50	PKS	esperamicin	Actinomadura verrucosospora
BGC0000862.3	0.49	other (other)	eicosapentaenoic acid	Shewanella pneumatophori
BGC0000869.5	0.48	other (other)	heterocyst glycolipids	Nostoc sp. 'Peltigera membranacea cyanobiont'

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000863.3	0.50	other (other)	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0002648.2	0.50	PKS	eicosapentaenoic acid	Shewanella sp. N2AIL
BGC0000861.5	0.50	other (other)	eicosapentaenoic acid	Shewanella sp. BR-2
BGC0000056.3	0.50	PKS	esperamicin	Actinomadura verrucosospora
BGC0000862.3	0.49	other (other)	eicosapentaenoic acid	Shewanella pneumatophori
BGC0000869.5	0.48	other (other)	heterocyst glycolipids	Nostoc sp. 'Peltigera membranacea cyanobiont'

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.81 out of 27.55

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 31.73 out of 35.63

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47

Confidence: medium

Additional weak hits (12):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.13 out of 25.88

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.74 out of 25.88

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.22 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.34 out of 36.54

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.50 out of 30.22

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.86 out of 30.22

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.51 out of 32.93

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.81 out of 21.84

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.50 out of 30.98

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.10 out of 30.98

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 226390 - 255217:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

INP57_RS24080: mal

PKS_AT (562..845): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 86.1
Methoxymalonyl-CoA: 29.9
inactive: 27.2
Methylmalonyl-CoA: 25.2
Propionyl-CoA: 21.5
2-Methylbutyryl-CoA: 14.1
fatty_acid: 10.6
CHC-CoA: 3.4
Isobutyryl-CoA: 2.2
Ethylmalonyl-CoA: 0.8
trans-1,2-CPDA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
NrtR	NAD synthesis repressor
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems

NZ_JADDUE010000012.1 - Region 1 - amglyccycl

Download region GenBank file

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Location: 111,742 - 132,938 nt. (total: 21,197 nt) Show pHMM detection rules used

amglyccycl: (DOIS or ValA or salQ or strH or strK1 or strK2 or NeoL or SpcFG or SpcDK_glyc)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

INP57_RS24675: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

INP57_RS24680: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Ligases: ligase synthase

INP57_RS24645: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

INP57_RS24685: 3-dehydroquinate synthase

smcogs: SMCOG1183: 3-dehydroquinate synthase

INP57_RS24750: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001825.4	0.55	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000701.5	0.52	saccharide	jinggangmycin	Streptomyces hygroscopicus subsp. yingchengensis
BGC0000925.5	0.42	other (other)	quinolobactin	Pseudomonas fluorescens
BGC0001896.4	0.41	other (other)	carbazomycin B	Streptomyces luteoverticillatus
BGC0002474.2	0.40	NRPS	agrobactin	Agrobacterium tumefaciens
BGC0002439.3	0.39	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus
BGC0002213.3	0.39	PKS	HEx-pks16 polyketide	Punctularia strigosozonata HHB-11173 SS5
BGC0002706.2	0.39	NRPS	saframycin Mx1	Myxococcus xanthus
BGC0000722.5	0.38	other (cyclitol), saccharide	validamycin A	Streptomyces hygroscopicus subsp. jinggangensis
BGC0000649.3	0.37	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001825.4	0.55	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000701.5	0.52	saccharide	jinggangmycin	Streptomyces hygroscopicus subsp. yingchengensis
BGC0000925.5	0.42	other (other)	quinolobactin	Pseudomonas fluorescens
BGC0001896.4	0.41	other (other)	carbazomycin B	Streptomyces luteoverticillatus
BGC0002474.2	0.40	NRPS	agrobactin	Agrobacterium tumefaciens
BGC0002439.3	0.39	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus
BGC0002213.3	0.39	PKS	HEx-pks16 polyketide	Punctularia strigosozonata HHB-11173 SS5
BGC0002706.2	0.39	NRPS	saframycin Mx1	Myxococcus xanthus
BGC0000722.5	0.38	other (cyclitol), saccharide	validamycin A	Streptomyces hygroscopicus subsp. jinggangensis
BGC0000649.3	0.37	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.45 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.70 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.72 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.66 out of 31.73

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JADDUE010000013.1 - Region 1 - redox-cofactor

Download region GenBank file

Download region SVG

Location: 19,375 - 42,157 nt. (total: 22,783 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

INP57_RS25135: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

INP57_RS25145: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase

INP57_RS25075: methyltransferase

smcogs: SMCOG1089: methyltransferase

INP57_RS25125: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000231.5	0.44	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000906.3	0.43	other (other)	heme D1	Heliophilum fasciatum
BGC0000234.5	0.42	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001928.2	0.40	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000204.5	0.40	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0001723.5	0.40	PKS	oviedomycin	Streptomyces antibioticus
BGC0002216.3	0.39	terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0000874.5	0.39	other (other)	blasticidin S	Streptomyces griseochromogenes
BGC0000595.3	0.39	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000231.5	0.44	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000906.3	0.43	other (other)	heme D1	Heliophilum fasciatum
BGC0000234.5	0.42	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001928.2	0.40	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000204.5	0.40	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0001723.5	0.40	PKS	oviedomycin	Streptomyces antibioticus
BGC0002216.3	0.39	terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0000874.5	0.39	other (other)	blasticidin S	Streptomyces griseochromogenes
BGC0000595.3	0.39	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.88 out of 29.38

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.93 out of 23.79

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.90 out of 20.97

Confidence: medium

Additional weak hits (9):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.07 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.44 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.47 out of 29.38

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.90 out of 26.85

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.98 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.44 out of 28.19

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.41 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.20 out of 30.11

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.78 out of 27.78

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Mycofactocin_RRE; Location: 21 - 99; Score: 79.5

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
IolR	Regulator of the inositol catabolism

NZ_JADDUE010000013.1 - Region 2 - redox-cofactor

Download region GenBank file

Download region SVG

Location: 71,802 - 93,882 nt. (total: 22,081 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

INP57_RS25385: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

INP57_RS25395: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

Transferases: aminotransferase

INP57_RS25310: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.47	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0000855.3	0.47	other (other)	ectoine	Methylomicrobium kenyense
BGC0000858.3	0.47	other (other)	ectoine	Methylobacter marinus
BGC0000860.3	0.47	other (other)	ectoine	Methylarcula marina
BGC0002052.3	0.45	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.45	other (other)	ectoine	Streptomyces anulatus
BGC0000919.5	0.44	other (other)	phaseolotoxin	Pseudomonas syringae
BGC0000707.5	0.42	saccharide	kasugamycin	Streptomyces kasugaensis
BGC0000663.5	0.41	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000905.5	0.39	other (other)	heme D1	Heliobacillus mobilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.47	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0000855.3	0.47	other (other)	ectoine	Methylomicrobium kenyense
BGC0000858.3	0.47	other (other)	ectoine	Methylobacter marinus
BGC0000860.3	0.47	other (other)	ectoine	Methylarcula marina
BGC0002052.3	0.45	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.45	other (other)	ectoine	Streptomyces anulatus
BGC0000919.5	0.44	other (other)	phaseolotoxin	Pseudomonas syringae
BGC0000707.5	0.42	saccharide	kasugamycin	Streptomyces kasugaensis
BGC0000663.5	0.41	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000905.5	0.39	other (other)	heme D1	Heliobacillus mobilis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.20 out of 19.26

Confidence: medium

Additional weak hits (11):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.67 out of 20.01

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.76 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.62 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.59 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.17 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.19 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.87 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.09 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.78 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.89 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.42 out of 28.19

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: PqqD_RRE; Location: 16 - 98; Score: 70.8

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_JADDUE010000015.1 - Region 1 - lanthipeptide-class-i

Download region GenBank file

Download region SVG

Location: 93,370 - 118,167 nt. (total: 24,798 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase dehydratase

INP57_RS26825: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

INP57_RS26830: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

INP57_RS26865: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002635.2	0.52	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000544.4	0.47	ribosomal	planosporicin	Planomonospora alba
BGC0001289.5	0.47	ribosomal	penisin	Paenibacillus ehimensis
BGC0000542.3	0.44	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.44	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000540.5	0.44	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000508.3	0.43	ribosomal	epidermin	Staphylococcus epidermidis
BGC0000556.5	0.43	ribosomal	streptin	Streptococcus pyogenes
BGC0001727.3	0.42	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000506.4	0.41	ribosomal	entianin	Bacillus subtilis subsp. spizizenii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002635.2	0.52	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000544.4	0.47	ribosomal	planosporicin	Planomonospora alba
BGC0001289.5	0.47	ribosomal	penisin	Paenibacillus ehimensis
BGC0000542.3	0.44	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.44	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000540.5	0.44	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000508.3	0.43	ribosomal	epidermin	Staphylococcus epidermidis
BGC0000556.5	0.43	ribosomal	streptin	Streptococcus pyogenes
BGC0001727.3	0.42	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000506.4	0.41	ribosomal	entianin	Bacillus subtilis subsp. spizizenii

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for INP57_RS26825

INP57_RS26820

Leader:

MAANTTTLSRTEDVDISDDFTLDFQVIESAYPL

Core:

AKLSCDTDDGCGQTCSTSACNSQANNPS

Core with dehydrations:

AKLDhaCysDDhbDDGCysGQDhbCysDhaDhbDhaACysNDhaQANNPDha

antiSMASH-DB 4.0 matches for INP57_RS26820

100.0%

NZ_JADDUE010000015.1and 1 other:

NZ_JADDUE010000015.1 Lanthipeptides: INP57_RS26820_lanthipeptide

Lanthipeptides: INP57_RS26820_lanthipeptide

1

AKLSCDTDDGCGQTCSTSACNSQANNPS

28

AKLSCDTDDGCGQTCSTSACNSQANNPS

1

AKLSCDTDDGCGQTCSTSACNSQANNPS

28

92.9%

NZ_CP076538.1and 1 other:

NZ_CP076538.1 Lanthipeptides: KOI47_RS17130_lanthipeptide

Lanthipeptides: KOI47_RS17130_lanthipeptide

1

AKLSCDTDDGCGQTCSTSACNSQANNPS

28

AKLSCDT DGCGQTCSTSACNSQANNP+

1

AKLSCDTSDGCGQTCSTSACNSQANNPA

28

67.9%

NZ_VLLL01000010.1and 1 other:

NZ_VLLL01000010.1 Lanthipeptides: LX16_RS23985_lanthipeptide

Lanthipeptides: LX16_RS23985_lanthipeptide

3

LSCDTDDGCGQTCSTSACNSQANNP

27

L CDT DGCG TC+TSACNS NNP

1

LRCDTSDGCGSTCATSACNSATNNP

25

with 182 more sequence matches

Only the first 10 are displayed here.

64.3%

NZ_ATYW01000025.1and 1 other:

NZ_ATYW01000025.1 Lanthipeptides: YWW_RS32370_lanthipeptide

Lanthipeptides: YWW_RS32370_lanthipeptide

3

LSCDTDDGCGQTCSTSACNSQANNP

27

L CDT DGCG TC TSAC+S NNP

1

LRCDTSDGCGNTCQTSACSSFTNNP

25

64.3%

NZ_KB905816.1and 1 other:

NZ_KB905816.1 Lanthipeptides: F603_RS35860_lanthipeptide

Lanthipeptides: F603_RS35860_lanthipeptide

1

AKLSCDTDDGCGQTCSTSACNSQANNPS

28

KL CDT DGCG TCS SACNS ++P+

1

GKLMCDTSDGCGSTCSGSACNSFTDDPA

28

64.3%

NZ_KI632511.1and 1 other:

NZ_KI632511.1 Lanthipeptides: ACTRO_RS29755_lanthipeptide

Lanthipeptides: ACTRO_RS29755_lanthipeptide

3

LSCDTDDGCGQTCSTSACNSQANNPS

28

L CDTDDGCG TCS SAC + +N+PS

3

LMCDTDDGCGSTCSNSACATGSNDPS

28

64.3%

NZ_PGGV01000032.1and 1 other:

NZ_PGGV01000032.1 Lanthipeptides: CUT39_RS12965_lanthipeptide

Lanthipeptides: CUT39_RS12965_lanthipeptide

3

LSCDTDDGCGQTCSTSACNSQANNP

27

L CDTDDGCG TC SAC S NNP

1

LRCDTDDGCGNTCQGSACASFTNNP

25

60.7%

NZ_AP018365.1and 1 other:

NZ_AP018365.1 Lanthipeptides: RVR_RS19640_lanthipeptide

Lanthipeptides: RVR_RS19640_lanthipeptide

3

LSCDTDDGCGQTCS--TSACNSQANNPS

28

L CDT DGCG TCS SAC+S A +P+

1

LMCDTGDGCGSTCSNGASACDSAAGDPA

28

60.7%

NZ_FNCN01000038.1and 3 others:

NZ_FNCN01000038.1 Lanthipeptides: BLQ73_RS26460_lanthipeptideNZ_QOIL01000011.1 Lanthipeptides: DQ384_RS20745_lanthipeptideNZ_QOIL01000011.1 Lanthipeptides: DQ384_RS20745_lanthipeptide

Lanthipeptides: BLQ73_RS26460_lanthipeptide

5

CDTDDGCGQTCSTSACNSQANNPS

28

C TDDGCG TCSTSAC++ +N+PS

2

CATDDGCGTTCSTSACSTSSNDPS

25

58.6%

NZ_FNIX01000023.1and 3 others:

NZ_FNIX01000023.1 Lanthipeptides: BLQ91_RS35110_lanthipeptideNZ_QQAU01000001.1 Lanthipeptides: DFR72_RS05535_lanthipeptideNZ_QQAU01000001.1 Lanthipeptides: DFR72_RS05535_lanthipeptide

Lanthipeptides: BLQ91_RS35110_lanthipeptide

3

LSCDTDDGCGQTCSTSACNSQANNP

27

+SCDT DGCG TC+TSAC S +N+P

4

MSCDTSDGCGDTCNTSACASGSNDP

28

58.6%

NZ_FOGI01000015.1and 5 others:

NZ_FOGI01000015.1 Lanthipeptides: BMY07_RS29195_lanthipeptideNZ_FOKG01000045.1 Lanthipeptides: BM199_RS32645_lanthipeptideNZ_FOKG01000045.1 Lanthipeptides: BM199_RS32645_lanthipeptideNZ_LT629789.1 Lanthipeptides: BLU53_RS35595_lanthipeptideNZ_LT629789.1 Lanthipeptides: BLU53_RS35595_lanthipeptide

Lanthipeptides: BMY07_RS29195_lanthipeptide

5

CDTDDGCGQTCS--TSACNSQANNPS

28

C TDDGCG TC+ SACNS A++PS

4

CPTDDGCGNTCAGNDSACNSFADDPS

29

57.1%

NZ_CP070499.1and 1 other:

NZ_CP070499.1 Lanthipeptides: JQS43_RS22025_lanthipeptide

Lanthipeptides: JQS43_RS22025_lanthipeptide

5

CDTDDGCGQTCSTSACNSQANNPS

28

CDT D CG TC TSACNS + +PS

1

CDTSDNCGATCGTSACNSGSLDPS

24

57.1%

NZ_JAICDF010000011.1and 1 other:

NZ_JAICDF010000011.1 Lanthipeptides: K2F48_RS29725_lanthipeptide

Lanthipeptides: K2F48_RS29725_lanthipeptide

5

CDTDDGCGQTCS--TSACNSQANNPS

28

C TDDGCG TCS S CNS ++PS

3

CPTDDGCGNTCSGNASTCNSAFDDPS

28

MIBiG 4.0 matches for INP57_RS26820

17.9%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

11

CGQTCSTS

18

CG CS S

6

CGFCCSCS

13

14.3%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

11

CGQTCS

16

C Q+CS

1

CRQSCS

6

14.3%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

15

CSTSACNSQ

23

C T+ C S+

17

CPTTKCTSK

25

with 1 more sequence matches

10.8%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

15

CSTSACNSQ

23

C T+ C S+

28

CPTTKCTSR

36

Lanthipeptide(s) for INP57_RS26835

INP57_RS26820

Leader:

MAANTTTLSRTEDVDISDDFTLDFQVIESAYPL

Core:

AKLSCDTDDGCGQTCSTSACNSQANNPS

Core with dehydrations:

AKLDhaCysDDhbDDGCysGQDhbCysDhaDhbDhaACysNDhaQANNPDha

antiSMASH-DB 4.0 matches for INP57_RS26820

100.0%

NZ_JADDUE010000015.1and 1 other:

NZ_JADDUE010000015.1 Lanthipeptides: INP57_RS26820_lanthipeptide

Lanthipeptides: INP57_RS26820_lanthipeptide

1

AKLSCDTDDGCGQTCSTSACNSQANNPS

28

AKLSCDTDDGCGQTCSTSACNSQANNPS

1

AKLSCDTDDGCGQTCSTSACNSQANNPS

28

92.9%

NZ_CP076538.1and 1 other:

NZ_CP076538.1 Lanthipeptides: KOI47_RS17130_lanthipeptide

Lanthipeptides: KOI47_RS17130_lanthipeptide

1

AKLSCDTDDGCGQTCSTSACNSQANNPS

28

AKLSCDT DGCGQTCSTSACNSQANNP+

1

AKLSCDTSDGCGQTCSTSACNSQANNPA

28

67.9%

NZ_VLLL01000010.1and 1 other:

NZ_VLLL01000010.1 Lanthipeptides: LX16_RS23985_lanthipeptide

Lanthipeptides: LX16_RS23985_lanthipeptide

3

LSCDTDDGCGQTCSTSACNSQANNP

27

L CDT DGCG TC+TSACNS NNP

1

LRCDTSDGCGSTCATSACNSATNNP

25

with 182 more sequence matches

Only the first 10 are displayed here.

64.3%

NZ_ATYW01000025.1and 1 other:

NZ_ATYW01000025.1 Lanthipeptides: YWW_RS32370_lanthipeptide

Lanthipeptides: YWW_RS32370_lanthipeptide

3

LSCDTDDGCGQTCSTSACNSQANNP

27

L CDT DGCG TC TSAC+S NNP

1

LRCDTSDGCGNTCQTSACSSFTNNP

25

64.3%

NZ_KB905816.1and 1 other:

NZ_KB905816.1 Lanthipeptides: F603_RS35860_lanthipeptide

Lanthipeptides: F603_RS35860_lanthipeptide

1

AKLSCDTDDGCGQTCSTSACNSQANNPS

28

KL CDT DGCG TCS SACNS ++P+

1

GKLMCDTSDGCGSTCSGSACNSFTDDPA

28

64.3%

NZ_KI632511.1and 1 other:

NZ_KI632511.1 Lanthipeptides: ACTRO_RS29755_lanthipeptide

Lanthipeptides: ACTRO_RS29755_lanthipeptide

3

LSCDTDDGCGQTCSTSACNSQANNPS

28

L CDTDDGCG TCS SAC + +N+PS

3

LMCDTDDGCGSTCSNSACATGSNDPS

28

64.3%

NZ_PGGV01000032.1and 1 other:

NZ_PGGV01000032.1 Lanthipeptides: CUT39_RS12965_lanthipeptide

Lanthipeptides: CUT39_RS12965_lanthipeptide

3

LSCDTDDGCGQTCSTSACNSQANNP

27

L CDTDDGCG TC SAC S NNP

1

LRCDTDDGCGNTCQGSACASFTNNP

25

60.7%

NZ_AP018365.1and 1 other:

NZ_AP018365.1 Lanthipeptides: RVR_RS19640_lanthipeptide

Lanthipeptides: RVR_RS19640_lanthipeptide

3

LSCDTDDGCGQTCS--TSACNSQANNPS

28

L CDT DGCG TCS SAC+S A +P+

1

LMCDTGDGCGSTCSNGASACDSAAGDPA

28

60.7%

NZ_FNCN01000038.1and 3 others:

NZ_FNCN01000038.1 Lanthipeptides: BLQ73_RS26460_lanthipeptideNZ_QOIL01000011.1 Lanthipeptides: DQ384_RS20745_lanthipeptideNZ_QOIL01000011.1 Lanthipeptides: DQ384_RS20745_lanthipeptide

Lanthipeptides: BLQ73_RS26460_lanthipeptide

5

CDTDDGCGQTCSTSACNSQANNPS

28

C TDDGCG TCSTSAC++ +N+PS

2

CATDDGCGTTCSTSACSTSSNDPS

25

58.6%

NZ_FNIX01000023.1and 3 others:

NZ_FNIX01000023.1 Lanthipeptides: BLQ91_RS35110_lanthipeptideNZ_QQAU01000001.1 Lanthipeptides: DFR72_RS05535_lanthipeptideNZ_QQAU01000001.1 Lanthipeptides: DFR72_RS05535_lanthipeptide

Lanthipeptides: BLQ91_RS35110_lanthipeptide

3

LSCDTDDGCGQTCSTSACNSQANNP

27

+SCDT DGCG TC+TSAC S +N+P

4

MSCDTSDGCGDTCNTSACASGSNDP

28

58.6%

NZ_FOGI01000015.1and 5 others:

NZ_FOGI01000015.1 Lanthipeptides: BMY07_RS29195_lanthipeptideNZ_FOKG01000045.1 Lanthipeptides: BM199_RS32645_lanthipeptideNZ_FOKG01000045.1 Lanthipeptides: BM199_RS32645_lanthipeptideNZ_LT629789.1 Lanthipeptides: BLU53_RS35595_lanthipeptideNZ_LT629789.1 Lanthipeptides: BLU53_RS35595_lanthipeptide

Lanthipeptides: BMY07_RS29195_lanthipeptide

5

CDTDDGCGQTCS--TSACNSQANNPS

28

C TDDGCG TC+ SACNS A++PS

4

CPTDDGCGNTCAGNDSACNSFADDPS

29

57.1%

NZ_CP070499.1and 1 other:

NZ_CP070499.1 Lanthipeptides: JQS43_RS22025_lanthipeptide

Lanthipeptides: JQS43_RS22025_lanthipeptide

5

CDTDDGCGQTCSTSACNSQANNPS

28

CDT D CG TC TSACNS + +PS

1

CDTSDNCGATCGTSACNSGSLDPS

24

57.1%

NZ_JAICDF010000011.1and 1 other:

NZ_JAICDF010000011.1 Lanthipeptides: K2F48_RS29725_lanthipeptide

Lanthipeptides: K2F48_RS29725_lanthipeptide

5

CDTDDGCGQTCS--TSACNSQANNPS

28

C TDDGCG TCS S CNS ++PS

3

CPTDDGCGNTCSGNASTCNSAFDDPS

28

MIBiG 4.0 matches for INP57_RS26820

17.9%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

11

CGQTCSTS

18

CG CS S

6

CGFCCSCS

13

14.3%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

11

CGQTCS

16

C Q+CS

1

CRQSCS

6

14.3%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

15

CSTSACNSQ

23

C T+ C S+

17

CPTTKCTSK

25

with 1 more sequence matches

10.8%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

15

CSTSACNSQ

23

C T+ C S+

28

CPTTKCTSR

36

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.31 out of 18.57

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46

Confidence: medium

Additional weak hits (5):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.17 out of 39.62

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.47 out of 32.74

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.76 out of 26.33

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.03 out of 29.65

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.97 out of 30.98

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

INP57_RS26820 - Class I

Cleavage pHMM score: -12.10

RODEO score: 24

Monoisotopic mass: 2633.1 Da

Molecular weight: 2634.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2652.8 Da N = 1; 2670.8 Da N = 2; 2688.8 Da N = 3; 2706.8 Da N = 4

INP57_RS26820 - Class I

Cleavage pHMM score: -12.10

RODEO score: 24

Monoisotopic mass: 2633.1 Da

Molecular weight: 2634.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2652.8 Da N = 1; 2670.8 Da N = 2; 2688.8 Da N = 3; 2706.8 Da N = 4

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 156 - 257; Score: 57.8

TFBS definitions

Regulator	Description
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NZ_JADDUE010000016.1 - Region 1 - NRPS-like

Download region GenBank file

Download region SVG

Location: 1 - 26,276 nt. (total: 26,276 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

INP57_RS26920: methyltransferase

smcogs: SMCOG1248: methyltransferase

Hydrolases: hydrolase

INP57_RS26970: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Lyases: lyase

INP57_RS26945: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Isomerases: racemase

INP57_RS26930: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Ligases: ligase synthase

INP57_RS26890: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

INP57_RS26935: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001197.5	0.45	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002656.2	0.45	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0001517.3	0.44	NRPS	asperphenamate	Aspergillus terreus NIH2624
BGC0001483.4	0.42	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0000554.4	0.41	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002313.3	0.41	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000410.5	0.41	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0002805.2	0.41	other (other)	Azodyrecin A, Azodyrecin B, Azodyrecin C	Streptomyces mirabilis strain P8-A
BGC0002567.2	0.40	other (other)	EDHA	Streptomyces sp. MA5143a

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001197.5	0.45	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002656.2	0.45	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0001517.3	0.44	NRPS	asperphenamate	Aspergillus terreus NIH2624
BGC0001483.4	0.42	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0000554.4	0.41	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002313.3	0.41	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000410.5	0.41	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0002805.2	0.41	other (other)	Azodyrecin A, Azodyrecin B, Azodyrecin C	Streptomyces mirabilis strain P8-A
BGC0002567.2	0.40	other (other)	EDHA	Streptomyces sp. MA5143a

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.90 out of 26.85

Confidence: medium

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.97 out of 23.43

Confidence: medium

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 25.32 out of 29.65

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.00 out of 28.19

Confidence: medium

Additional weak hits (10):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.46 out of 39.62

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.15 out of 20.97

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.79 out of 23.43

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.84 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.19 out of 29.38

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.92 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.56 out of 24.78

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.11 out of 24.78

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.05 out of 28.14

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.07 out of 36.53

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 26276:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

INP57_RS26890: X

AMP-binding (91..518): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -WLLHLAGRASSMLDFGQEVHA--------MCGS
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator
LexA variant 1	Repressor of DNA damage response
RutR	Regulator of the pyrimidine and purine metabolism
ZuR variant 1	Zinc-responsive repressor

NZ_JADDUE010000018.1 - Region 1 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 1 - 33,523 nt. (total: 33,523 nt) Show pHMM detection rules used

Region on contig edge.

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

INP57_RS27845: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

INP57_RS27895: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

INP57_RS27930: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: decarboxylase hydratase

INP57_RS27860: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

INP57_RS27905: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002469.2	0.67	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001478.5	0.62	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0001572.3	0.61	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002692.2	0.60	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000941.3	0.60	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2	0.59	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001531.5	0.58	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0000295.5	0.55	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002464.3	0.54	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0001713.5	0.54	other (other)	ochrobactin	Ochrobactrum anthropi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002469.2	0.67	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001478.5	0.62	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0001572.3	0.61	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002692.2	0.60	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000941.3	0.60	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2	0.59	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001531.5	0.58	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0000295.5	0.55	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002464.3	0.54	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0001713.5	0.54	other (other)	ochrobactin	Ochrobactrum anthropi

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.33 out of 19.52

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.07 out of 36.53

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.28 out of 26.85

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 25.84 out of 30.12

Confidence: medium

Additional weak hits (5):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.69 out of 21.55

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.98 out of 30.22

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.30 out of 24.78

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.73 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.99 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
DmdR1	Iron(II)-dependent repressor
OsdR	Development and stress management regulator
RutR	Regulator of the pyrimidine and purine metabolism

NZ_JADDUE010000019.1 - Region 1 - lassopeptide

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Location: 11,864 - 34,317 nt. (total: 22,454 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase phosphatase

INP57_RS28175: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

INP57_RS28225: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Lyases: dehydratase

INP57_RS28135: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

INP57_RS28140: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002053.3	0.73	ribosomal	ulleungdin	Streptomyces sp.
BGC0001539.4	0.72	ribosomal	cattlecin	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001507.3	0.71	ribosomal	anantin C	Streptomyces olindensis
BGC0002318.2	0.61	ribosomal	canucin A, canucin B	Streptomyces canus
BGC0001506.5	0.60	ribosomal	anantin B1, anantin B2	Streptomyces sp. NRRL S-146
BGC0002074.2	0.60	ribosomal	huascopeptin	Streptomyces huasconensis
BGC0001548.4	0.59	ribosomal	citrulassin A	Streptomyces albulus
BGC0001307.3	0.58	ribosomal	chaxapeptin	Streptomyces leeuwenhoekii
BGC0002064.2	0.58	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0001551.4	0.55	ribosomal	citrulassin E	Streptomyces glaucescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002053.3	0.73	ribosomal	ulleungdin	Streptomyces sp.
BGC0001539.4	0.72	ribosomal	cattlecin	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001507.3	0.71	ribosomal	anantin C	Streptomyces olindensis
BGC0002318.2	0.61	ribosomal	canucin A, canucin B	Streptomyces canus
BGC0001506.5	0.60	ribosomal	anantin B1, anantin B2	Streptomyces sp. NRRL S-146
BGC0002074.2	0.60	ribosomal	huascopeptin	Streptomyces huasconensis
BGC0001548.4	0.59	ribosomal	citrulassin A	Streptomyces albulus
BGC0001307.3	0.58	ribosomal	chaxapeptin	Streptomyces leeuwenhoekii
BGC0002064.2	0.58	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0001551.4	0.55	ribosomal	citrulassin E	Streptomyces glaucescens

Similar known clusters from MIBiG 4.0

Similar subclusters

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47

Confidence: medium

Additional weak hits (4):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.91 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.59 out of 32.74

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.72 out of 30.98

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 0 - 84; Score: 71.9; RRE type: Lasso_Fused_RRE; Location: 0 - 61; Score: 27.4

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_JADDUE010000001.1 - Region 1 - ectoine

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Location: 534,090 - 544,479 nt. (total: 10,390 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

INP57_RS02450: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.81	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.81	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000857.3	0.59	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.59	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.59	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000856.3	0.55	other (other)	ectoine	Methylophaga thalassica

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.81	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.81	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000857.3	0.59	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.59	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.59	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000856.3	0.55	other (other)	ectoine	Methylophaga thalassica

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (2):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.92 out of 26.85

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.79 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
VqsM	Regulator of quorum-sensing signalling systems

NZ_JADDUE010000020.1 - Region 1 - lanthipeptide-class-i

Download region GenBank file

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Location: 16,305 - 40,893 nt. (total: 24,589 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase dehydratase

INP57_RS28485: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

INP57_RS28490: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.76	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0002635.2	0.69	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000544.4	0.61	ribosomal	planosporicin	Planomonospora alba
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0001660.3	0.51	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000542.3	0.51	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.51	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000506.4	0.51	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000556.5	0.50	ribosomal	streptin	Streptococcus pyogenes
BGC0000529.5	0.50	ribosomal	microbisporicin A2	Microbispora corallina

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.76	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0002635.2	0.69	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000544.4	0.61	ribosomal	planosporicin	Planomonospora alba
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0001660.3	0.51	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000542.3	0.51	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.51	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000506.4	0.51	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000556.5	0.50	ribosomal	streptin	Streptococcus pyogenes
BGC0000529.5	0.50	ribosomal	microbisporicin A2	Microbispora corallina

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for INP57_RS28490

INP57_RS28495

Leader:

MSAATDQAVAEAEVDLFDLDLEVGFEATMANPA

Core:

VTSVSYCTPGCTSEGGGSNCSHCC

Core with dehydrations:

VDhbDhaVDhaYCysDhbPGCysDhbDhaEGGGDhaNCysDhaHCysCys

antiSMASH-DB 4.0 matches for INP57_RS28495

100.0%

NZ_JADDUE010000020.1:

Lanthipeptides: INP57_RS28495_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

VTSVSYCTPGCTSEGGGSNCSHCC

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

95.8%

NZ_JAMTCQ010000009.1:

Lanthipeptides: LY41_RS11610_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

VTSVSYCTPGCTSEGGGS CSHCC

1

VTSVSYCTPGCTSEGGGSGCSHCC

24

91.7%

NZ_FMHI01000015.1and 1 other:

NZ_LIXJ01000007.1 Lanthipeptides: AMK22_RS13160_lanthipeptide

Lanthipeptides: H180DRAFT_RS21560_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

+TSVSYCTPGCTSEGGGS CSHCC

1

ITSVSYCTPGCTSEGGGSGCSHCC

24

with 99 more sequence matches

Only the first 10 are displayed here.

91.7%

NZ_KB905819.1:

Lanthipeptides: F603_RS34750_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

VTS+SYCTPGCTSEGGGS CSHCC

1

VTSISYCTPGCTSEGGGSGCSHCC

24

87.5%

NZ_CP007699.2:

Lanthipeptides: T261_RS08380_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

VTS+SYCTPGCTS+GGGS CSHCC

1

VTSISYCTPGCTSDGGGSGCSHCC

24

87.5%

NZ_CP048882.1and 1 other:

NZ_CP048882.1 Lanthipeptides: G4Z16_RS06545_lanthipeptide

Lanthipeptides: G4Z16_RS06545_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

+TS+SYCTPGCTSEGGGS CSHCC

1

ITSISYCTPGCTSEGGGSGCSHCC

24

87.5%

NZ_FMZZ01000002.1:

Lanthipeptides: BLS56_RS30480_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

VTSVS CTPGCTS GGGSNCS CC

1

VTSVSLCTPGCTSPGGGSNCSFCC

24

87.5%

NZ_JAMHJQ010000009.1and 2 others:

NZ_KN039946.1 Lanthipeptides: FM21_RS35825_lanthipeptideNZ_LIPF01000002.1 Lanthipeptides: AMK11_RS10850_lanthipeptide

Lanthipeptides: M1203_RS22635_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

+TSVS+CTPGCTSEGGGS CSHCC

1

ITSVSWCTPGCTSEGGGSGCSHCC

24

87.5%

NZ_LIVZ01000011.1:

Lanthipeptides: AMK31_RS29125_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

+TSVSYCTPGCTS+GGGS CSHCC

1

ITSVSYCTPGCTSDGGGSGCSHCC

24

83.3%

NZ_JACHEM010000003.1:

Lanthipeptides: HNQ79_RS07795_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

+TSVS+CTPGCTS+GGGS CSHCC

1

ITSVSWCTPGCTSDGGGSGCSHCC

24

83.3%

NZ_KI866523.1:

Lanthipeptides: MPTA5024_RS39835_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

VTS S CTPGCTS GGGSNCS CC

1

VTSWSLCTPGCTSPGGGSNCSFCC

24

79.2%

NZ_AP023356.1:

Lanthipeptides: Aiant_RS23765_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

+TSVS CTPGCTS GGGS CS CC

1

ITSVSLCTPGCTSAGGGSQCSFCC

24

79.2%

NZ_AXWW01000016.1and 1 other:

NZ_JAMTCO010000009.1 Lanthipeptides: LV75_RS20160_lanthipeptide

Lanthipeptides: H504_RS39505_lanthipeptide

1

VTSVSYCTPGCTSEGGGSNCSHCC

24

+TS+S CTPGCTS GGGSNCS CC

1

ITSISLCTPGCTSAGGGSNCSFCC

24

MIBiG 4.0 matches for INP57_RS28495

23.5%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

1

VTSVSYCTPGCTS

13

+TS+S CTPGC +

1

ITSISLCTPGCKT

13

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.94 out of 26.85

Confidence: medium

Additional weak hits (4):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.53 out of 29.38

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.34 out of 29.65

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.77 out of 32.38

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

INP57_RS28495 - Class I

Cleavage pHMM score: 6.50

RODEO score: 29

Monoisotopic mass: 2193.8 Da

Molecular weight: 2195.4 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 2213.4 Da N = 1; 2231.4 Da N = 2; 2249.4 Da N = 3

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 172 - 264; Score: 49.5

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
MexT	Global virulence regulator
RutR	Regulator of the pyrimidine and purine metabolism

NZ_JADDUE010000021.1 - Region 1 - betalactone

Download region GenBank file

Download region SVG

Location: 5,882 - 34,535 nt. (total: 28,654 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

INP57_RS28620: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

INP57_RS28630: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

INP57_RS28635: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

INP57_RS28645: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

INP57_RS28650: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

INP57_RS28680: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

INP57_RS28740: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: dehalogenase

INP57_RS28700: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Lyases: dehydratase

INP57_RS28675: L-carnitine dehydratase/bile acid-inducible

smcogs: SMCOG1189: L-carnitine dehydratase/bile acid-inducible

Ligases: ligase synthase

INP57_RS28655: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

INP57_RS28685: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001201.3	0.51	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0000244.4	0.49	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0000706.3	0.47	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000252.5	0.46	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0000894.4	0.45	other (other)	citrinin	Monascus aurantiacus
BGC0000632.5	0.45	saccharide, terpene	brasilicardin A	Nocardia terpenica
BGC0000902.4	0.45	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0001465.5	0.44	other (other)	bromophene, bistribromopyrrole, pentabromopseudilin	Marinomonas mediterranea MMB-1
BGC0001463.4	0.44	other (other)	2,3,4,5-tetrabromopyrrole	Pseudoalteromonas piscicida
BGC0001464.3	0.44	other (other)	tetrabromopyrrole	Pseudoalteromonas sp. PS5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001201.3	0.51	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0000244.4	0.49	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0000706.3	0.47	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000252.5	0.46	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0000894.4	0.45	other (other)	citrinin	Monascus aurantiacus
BGC0000632.5	0.45	saccharide, terpene	brasilicardin A	Nocardia terpenica
BGC0000902.4	0.45	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0001465.5	0.44	other (other)	bromophene, bistribromopyrrole, pentabromopseudilin	Marinomonas mediterranea MMB-1
BGC0001463.4	0.44	other (other)	2,3,4,5-tetrabromopyrrole	Pseudoalteromonas piscicida
BGC0001464.3	0.44	other (other)	tetrabromopyrrole	Pseudoalteromonas sp. PS5

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.87 out of 20.97

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.48 out of 29.72

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.45 out of 25.31

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.69 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.96 out of 23.79

Confidence: medium

Additional weak hits (6):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.49 out of 31.73

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.79 out of 32.93

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.90 out of 26.85

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.09 out of 33.14

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.72 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
CcpA	Catabolite control protein A
IolR	Regulator of the inositol catabolism
NtrC	Nitrogen regulatory protein C

NZ_JADDUE010000023.1 - Region 1 - terpene-precursor

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Download region SVG

Location: 1 - 17,292 nt. (total: 17,292 nt) Show pHMM detection rules used

Region on contig edge.

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

INP57_RS28915: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

INP57_RS28920: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

INP57_RS28950: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Lyases: dehydratase

INP57_RS28960: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase

INP57_RS28935: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.49	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.49	other (ectoine)	ectoine	Streptomyces sp.
BGC0000854.3	0.46	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000664.5	0.41	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.41	terpene	isorenieratene	Streptomyces argillaceus
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3	0.40	terpene	carotenoid	Streptomyces avermitilis
BGC0000678.5	0.39	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000636.3	0.39	terpene	carotenoid	Brevibacterium linens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.49	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.49	other (ectoine)	ectoine	Streptomyces sp.
BGC0000854.3	0.46	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000664.5	0.41	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.41	terpene	isorenieratene	Streptomyces argillaceus
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3	0.40	terpene	carotenoid	Streptomyces avermitilis
BGC0000678.5	0.39	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000636.3	0.39	terpene	carotenoid	Brevibacterium linens

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

INP57_RS28935: PT_FPPS_like

Domain 1 (22 - 323): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.25 out of 29.72

Confidence: medium

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 26.87 out of 29.51

Confidence: strong

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.36 out of 25.31

Confidence: medium

Additional weak hits (2):

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.98 out of 35.63

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.39 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
DosR	Hypoxia stress response regulator
NtrC	Nitrogen regulatory protein C

NZ_JADDUE010000002.1 - Region 1 - RiPP-like

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Location: 287,765 - 298,577 nt. (total: 10,813 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

INP57_RS05720: methyltransferase

smcogs: SMCOG1089: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002665.2	0.37	ribosomal	3-thiaglutamate	Pseudomonas syringae pv. maculicola str. ES4326
BGC0001486.4	0.35	ribosomal	3-thiaglutamate	Pseudomonas syringae pv. maculicola str. ES4326
BGC0002578.2	0.33	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0002621.2	0.32	other (other)	angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine	Streptomyces angustmyceticus
BGC0000885.3	0.32	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000277.5	0.32	PKS	urdamycin	Streptomyces fradiae
BGC0001869.4	0.27	NRPS, other (phenazine)	griseoluteic acid, demethoxygriseoluteic acid, phenaszentine A, phenaszentine C, phenaszenketide C, phenaszenketide D	Xenorhabdus szentirmaii DSM 16338
BGC0000253.4	0.24	PKS	oviedomycin	Streptomyces antibioticus
BGC0002672.2	0.23	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.
BGC0000415.5	0.23	NRPS	quinomycin	Streptomyces griseovariabilis subsp. bandungensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002665.2	0.37	ribosomal	3-thiaglutamate	Pseudomonas syringae pv. maculicola str. ES4326
BGC0001486.4	0.35	ribosomal	3-thiaglutamate	Pseudomonas syringae pv. maculicola str. ES4326
BGC0002578.2	0.33	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0002621.2	0.32	other (other)	angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine	Streptomyces angustmyceticus
BGC0000885.3	0.32	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000277.5	0.32	PKS	urdamycin	Streptomyces fradiae
BGC0001869.4	0.27	NRPS, other (phenazine)	griseoluteic acid, demethoxygriseoluteic acid, phenaszentine A, phenaszentine C, phenaszenketide C, phenaszenketide D	Xenorhabdus szentirmaii DSM 16338
BGC0000253.4	0.24	PKS	oviedomycin	Streptomyces antibioticus
BGC0002672.2	0.23	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.
BGC0000415.5	0.23	NRPS	quinomycin	Streptomyces griseovariabilis subsp. bandungensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

Additional weak hits (2):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.84 out of 26.85

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.33 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production

NZ_JADDUE010000002.1 - Region 2 - betalactone

Download region GenBank file

Download region SVG

Location: 489,517 - 519,931 nt. (total: 30,415 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

INP57_RS06740: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

INP57_RS06755: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

INP57_RS06805: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

INP57_RS06815: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

INP57_RS06835: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: acetyltransferase methyltransferase

INP57_RS06760: methyltransferase

smcogs: SMCOG1089: methyltransferase

INP57_RS06800: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

Hydrolases: dehalogenase

INP57_RS06745: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Ligases: ligase synthase

INP57_RS06735: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

INP57_RS06795: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002276.2	0.54	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002007.2	0.50	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0002127.3	0.47	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000866.5	0.46	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.44	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0002347.3	0.44	other (other)	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus caeruleus WH1-2216-6
BGC0001334.5	0.44	other (other)	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0000686.3	0.44	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001333.5	0.43	other (other)	BE-54017	uncultured bacterium AB1650

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002276.2	0.54	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002007.2	0.50	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0002127.3	0.47	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000866.5	0.46	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.44	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0002347.3	0.44	other (other)	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus caeruleus WH1-2216-6
BGC0001334.5	0.44	other (other)	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0000686.3	0.44	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001333.5	0.43	other (other)	BE-54017	uncultured bacterium AB1650

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (10):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.50 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.18 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.40 out of 26.06

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.82 out of 30.97

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.68 out of 20.97

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.46 out of 27.55

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.19 out of 28.19

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.89 out of 24.78

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator

NZ_JADDUE010000003.1 - Region 1 - terpene

Download region GenBank file

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Location: 108,060 - 134,127 nt. (total: 26,068 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

INP57_RS08210: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

INP57_RS08235: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

INP57_RS08265: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

INP57_RS08280: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

INP57_RS08310: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

INP57_RS08315: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Ligases: synthetase

INP57_RS08260: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.62	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000648.3	0.50	terpene	carotenoid	Myxococcus xanthus
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000638.3	0.46	terpene	carotenoid	Pantoea ananatis
BGC0002309.2	0.46	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000664.5	0.46	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.62	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000648.3	0.50	terpene	carotenoid	Myxococcus xanthus
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000638.3	0.46	terpene	carotenoid	Pantoea ananatis
BGC0002309.2	0.46	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000664.5	0.46	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

INP57_RS08255: T2TS

Domain 1 (11 - 639): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

INP57_RS08260: PT_FPPS_like

Domain 1 (52 - 335): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

INP57_RS08270: PT_phytoene_like

Domain 1 (17 - 294): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

INP57_RS08275: PT_phytoene_like

Domain 1 (33 - 274): Prenyltransferase; Phytoene synthase like

Subtype: Hydroxysqualene synthase

Reactions:: PSPP → hydroxysqualene

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (9):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.84 out of 26.06

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.06 out of 25.75

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.56 out of 29.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.68 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.93 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.41 out of 31.73

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 25.31

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.88 out of 29.25

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description

NZ_JADDUE010000003.1 - Region 2 - terpene

Download region GenBank file

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Location: 148,002 - 170,254 nt. (total: 22,253 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

INP57_RS08420: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: cyclase

INP57_RS08425: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Ligases: synthase

INP57_RS08410: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

INP57_RS08455: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

INP57_RS08460: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.81	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001735.5	0.37	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0000943.5	0.35	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001959.4	0.35	other (other)	taylorflavin A, taylorflavin B	Streptomyces hiroshimensis
BGC0002095.3	0.33	NRPS	leupeptin Pr, leupeptin Ac	Streptomyces roseus
BGC0002510.2	0.32	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0000896.5	0.32	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000836.5	0.32	other (other)	APE Ec	Escherichia coli CFT073
BGC0000837.4	0.30	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0002315.2	0.30	PKS	accramycin A	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.81	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001735.5	0.37	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0000943.5	0.35	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001959.4	0.35	other (other)	taylorflavin A, taylorflavin B	Streptomyces hiroshimensis
BGC0002095.3	0.33	NRPS	leupeptin Pr, leupeptin Ac	Streptomyces roseus
BGC0002510.2	0.32	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0000896.5	0.32	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000836.5	0.32	other (other)	APE Ec	Escherichia coli CFT073
BGC0000837.4	0.30	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0002315.2	0.30	PKS	accramycin A	Streptomyces sp.

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene		germacradienol	C15	C1-C10	OH
sesquiterpene		geosmin	C12	C1-C10	OH

Genes with terpene domains:

INP57_RS08425: T1TS + T1TS

Domain 1 (1 - 328): Type 1 terpene synthase

Subtype: Geosmin synthase, N terminal domain

Reactions:: FPP → germacradienol

Domain 2 (343 - 708): Type 1 terpene synthase

Subtype: Geosmin synthase, C terminal domain

Reactions:: germacradienol → geosmin

Transcription Factor Binding Sites

Binding sites found:

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.51 out of 30.11

Confidence: medium

Additional weak hits (6):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.28 out of 27.55

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.07 out of 20.97

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.86 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.88 out of 29.38

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.83 out of 29.65

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
CelR	Cellobiose uptake repressor

NZ_JADDUE010000003.1 - Region 3 - terpene

Download region GenBank file

Download region SVG

Location: 392,988 - 414,199 nt. (total: 21,212 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

INP57_RS09545: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Lyases: hydratase

INP57_RS09495: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000563.4	0.41	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000501.3	0.40	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000548.4	0.37	ribosomal	salivaricin A	Streptococcus salivarius
BGC0002116.3	0.36	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000497.3	0.36	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000552.3	0.36	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001364.3	0.36	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0002567.2	0.35	other (other)	EDHA	Streptomyces sp. MA5143a

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000563.4	0.41	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000501.3	0.40	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000548.4	0.37	ribosomal	salivaricin A	Streptococcus salivarius
BGC0002116.3	0.36	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000497.3	0.36	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000552.3	0.36	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001364.3	0.36	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0002567.2	0.35	other (other)	EDHA	Streptomyces sp. MA5143a

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

INP57_RS09525: Lycopene_cycl

Domain 1 (6 - 374): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

Binding sites found:

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.08 out of 27.04

Confidence: medium

Additional weak hits (6):

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.95 out of 23.43

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.90 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.43 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.44 out of 27.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.00 out of 29.65

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.05 out of 26.06

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
DasR	N-acetylglucosamine dependent repressor

NZ_JADDUE010000004.1 - Region 1 - T1PKS

Download region GenBank file

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Location: 36,907 - 83,359 nt. (total: 46,453 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase transferase

INP57_RS10660: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

INP57_RS10715: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: esterase

INP57_RS10655: putative esterase

smcogs: SMCOG1104: putative esterase

Isomerases: isomerase

INP57_RS10595: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

INP57_RS10580: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

INP57_RS10630: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

INP57_RS10665: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

INP57_RS10670: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.74	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.73	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.73	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.74	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.73	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.73	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.37 out of 20.47

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.56 out of 23.79

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

Additional weak hits (20):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.12 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.14 out of 28.14

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.58 out of 39.62

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.63 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.44 out of 28.14

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.80 out of 21.55

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 30.25

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.42 out of 31.73

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.76 out of 26.33

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.74 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 21.18 out of 36.54

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.56 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.22 out of 26.12

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.04 out of 35.63

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.09 out of 35.63

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.39 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.02 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.07 out of 24.78

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 36906 - 83359:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

INP57_RS10665: mmal

PKS_AT (627..910): mmal

ATSignature: Propionyl-CoA, Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Propionyl-CoA: 62.5%; Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 106.4
Malonyl-CoA: 99.8
Methoxymalonyl-CoA: 95.8
Ethylmalonyl-CoA: 87.2
Propionyl-CoA: 66.9
2-Methylbutyryl-CoA: 54.9
trans-1,2-CPDA: 54.5
fatty_acid: 51.4
Isobutyryl-CoA: 51.3
Acetyl-CoA: 50.9
inactive: 46.0
CHC-CoA: 45.4
Benzoyl-CoA: 32.2
3-Methylbutyryl-CoA: 16.6

INP57_RS10670: NH2

CAL_domain (50..495): NH2

minowa: NH2

Prediction, score:

NH2: 134.6
fatty_acid: 28.2
AHBA: 8.8
shikimic_acid: 0.0
Acetyl-CoA: -1.5

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
IolR	Regulator of the inositol catabolism
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems

NZ_JADDUE010000004.1 - Region 2 - indole

Download region GenBank file

Download region SVG

Location: 358,538 - 381,825 nt. (total: 23,288 nt) Show pHMM detection rules used

indole: (indsynth or dmat or indole_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

INP57_RS12120: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: methyltransferase

INP57_RS12075: methyltransferase

smcogs: SMCOG1089: methyltransferase

INP57_RS12090: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

INP57_RS12110: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Ligases: synthase

INP57_RS12130: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001224.5	0.54	other (other)	reductasporine	uncultured bacterium
BGC0000817.4	0.53	other (other)	methylarcyriarubin	uncultured bacterium
BGC0000829.5	0.53	other (other)	violacein	Chromobacterium violaceum
BGC0001223.5	0.52	other (other)	hydroxysporine	uncultured bacterium
BGC0001336.5	0.50	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0002482.2	0.47	other (other)	tjipanazole D, tjipanazole I, tjipanazole L, tjipanazole K, tjipanazole M	Symphyonema bifilamentata 97.28
BGC0000830.5	0.44	other (aminocoumarin)	violacein	uncultured bacterium
BGC0000831.3	0.44	other (other)	violacein	Duganella sp. B2
BGC0002043.3	0.44	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0001782.3	0.42	other (other)	spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G	Streptomyces sp. SCSIO 03032

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001224.5	0.54	other (other)	reductasporine	uncultured bacterium
BGC0000817.4	0.53	other (other)	methylarcyriarubin	uncultured bacterium
BGC0000829.5	0.53	other (other)	violacein	Chromobacterium violaceum
BGC0001223.5	0.52	other (other)	hydroxysporine	uncultured bacterium
BGC0001336.5	0.50	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0002482.2	0.47	other (other)	tjipanazole D, tjipanazole I, tjipanazole L, tjipanazole K, tjipanazole M	Symphyonema bifilamentata 97.28
BGC0000830.5	0.44	other (aminocoumarin)	violacein	uncultured bacterium
BGC0000831.3	0.44	other (other)	violacein	Duganella sp. B2
BGC0002043.3	0.44	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0001782.3	0.42	other (other)	spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G	Streptomyces sp. SCSIO 03032

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.81 out of 29.51

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

Additional weak hits (10):

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.74 out of 29.72

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.41 out of 27.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.86 out of 27.78

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.90 out of 29.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.40 out of 28.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.42 out of 28.19

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.12 out of 24.78

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.10 out of 35.63

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.46 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
DosR	Hypoxia stress response regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_JADDUE010000004.1 - Region 3 - RiPP-like

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Location: 412,977 - 424,218 nt. (total: 11,242 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acyltransferase

INP57_RS12280: acyltransferase

smcogs: SMCOG1141: acyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001682.3	0.45	other (other)	N-acyl lysine, N-acyl ornithine	Pseudomonas aeruginosa LESB58
BGC0000244.4	0.39	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0001157.6	0.31	ribosomal	bottromycin A2	Streptomyces scabiei 87.22
BGC0000468.5	0.31	ribosomal	bottromycin A2	Streptomyces bottropensis DSM40262
BGC0000470.6	0.30	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0000469.6	0.29	ribosomal	bottromycin A2	Streptomyces sp. BC16019
BGC0000603.5	0.28	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001146.5	0.27	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001145.5	0.26	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001753.3	0.25	ribosomal	radamycin, globimycin	Streptomyces globisporus subsp. globisporus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001682.3	0.45	other (other)	N-acyl lysine, N-acyl ornithine	Pseudomonas aeruginosa LESB58
BGC0000244.4	0.39	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0001157.6	0.31	ribosomal	bottromycin A2	Streptomyces scabiei 87.22
BGC0000468.5	0.31	ribosomal	bottromycin A2	Streptomyces bottropensis DSM40262
BGC0000470.6	0.30	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0000469.6	0.29	ribosomal	bottromycin A2	Streptomyces sp. BC16019
BGC0000603.5	0.28	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001146.5	0.27	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001145.5	0.26	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001753.3	0.25	ribosomal	radamycin, globimycin	Streptomyces globisporus subsp. globisporus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.50 out of 27.78

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JADDUE010000005.1 - Region 1 - hydroxytropolone

Download region GenBank file

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Location: 76,813 - 103,046 nt. (total: 26,234 nt) Show pHMM detection rules used

hydroxytropolone: (4HBT_2 and AMP-binding and cds(Acyl-CoA_dh_N and Acyl-CoA_dh_M and Acyl-CoA_dh_1) and cds(TPP_enzyme_N and TPP_enzyme_C))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

INP57_RS13120: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

INP57_RS13180: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: methyltransferase

INP57_RS13210: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: hydratase

INP57_RS13170: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase

INP57_RS13115: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

INP57_RS13165: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000706.3	0.48	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002405.2	0.46	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0002578.2	0.45	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000343.5	0.44	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001778.5	0.44	other (other)	showdomycin	Streptomyces showdoensis
BGC0000207.5	0.43	PKS	chartreusin	Streptomyces chartreusis
BGC0001810.3	0.42	PKS	trehangelin	Polymorphospora rubra
BGC0001343.3	0.41	PKS	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000925.5	0.40	other (other)	quinolobactin	Pseudomonas fluorescens
BGC0001521.3	0.40	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000706.3	0.48	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002405.2	0.46	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0002578.2	0.45	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000343.5	0.44	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001778.5	0.44	other (other)	showdomycin	Streptomyces showdoensis
BGC0000207.5	0.43	PKS	chartreusin	Streptomyces chartreusis
BGC0001810.3	0.42	PKS	trehangelin	Polymorphospora rubra
BGC0001343.3	0.41	PKS	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000925.5	0.40	other (other)	quinolobactin	Pseudomonas fluorescens
BGC0001521.3	0.40	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84

Confidence: medium

Additional weak hits (13):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.13 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.29 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.88 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 30.25

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.05 out of 24.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.75 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.81 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.84 out of 21.84

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.64 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.19 out of 28.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.20 out of 33.14

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.42 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.65 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MexT	Global virulence regulator

NZ_JADDUE010000005.1 - Region 2 - terpene

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Location: 224,741 - 245,751 nt. (total: 21,011 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

INP57_RS13870: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: methyltransferase

INP57_RS13865: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: protease

INP57_RS13885: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: dehydratase

INP57_RS13850: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.54	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.52	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000645.3	0.46	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0001227.3	0.44	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.44	terpene	carotenoid	Streptomyces avermitilis
BGC0002554.2	0.42	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0000597.4	0.41	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000639.3	0.40	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.40	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.54	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.52	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000645.3	0.46	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0001227.3	0.44	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.44	terpene	carotenoid	Streptomyces avermitilis
BGC0002554.2	0.42	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0000597.4	0.41	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000639.3	0.40	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.40	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

INP57_RS13860: PT_phytoene_like

Domain 1 (32 - 325): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.75 out of 23.79

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.57 out of 20.97

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.46 out of 28.19

Confidence: medium

Additional weak hits (3):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.79 out of 29.65

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.86 out of 23.43

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.64 out of 18.57

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
IolR	Regulator of the inositol catabolism
ZuR variant 1	Zinc-responsive repressor

NZ_JADDUE010000006.1 - Region 1 - terpene-precursor

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Location: 1,252 - 22,277 nt. (total: 21,026 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

INP57_RS14850: methyltransferase

smcogs: SMCOG1089: methyltransferase

INP57_RS14870: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

INP57_RS14885: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Ligases: synthetase

INP57_RS14890: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000657.5	0.46	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000664.5	0.40	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000665.5	0.39	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000649.3	0.39	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000678.5	0.39	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000905.5	0.39	other (other)	heme D1	Heliobacillus mobilis
BGC0001529.5	0.39	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001483.4	0.39	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000657.5	0.46	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000664.5	0.40	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000665.5	0.39	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000649.3	0.39	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000678.5	0.39	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000905.5	0.39	other (other)	heme D1	Heliobacillus mobilis
BGC0001529.5	0.39	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001483.4	0.39	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

INP57_RS14890: PT_FPPS_like

Domain 1 (53 - 340): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.80 out of 35.63

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

NZ_JADDUE010000006.1 - Region 2 - NRP-metallophore,NRPS

Download region GenBank file

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Location: 28,509 - 79,852 nt. (total: 51,344 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

INP57_RS15105: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

INP57_RS15160: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase phosphorylase

INP57_RS15030: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

INP57_RS15165: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

INP57_RS15110: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Ligases: ligase synthase

INP57_RS15000: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

INP57_RS15085: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

INP57_RS15150: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.87	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.76	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.75	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641.4	0.68	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.68	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641.4	0.67	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.93 out of 23.79

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.67 out of 19.26

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.90 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.86 out of 36.53

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Additional weak hits (20):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.68 out of 39.62

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.24 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.58 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.95 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.35 out of 29.38

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.05 out of 21.55

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.68 out of 20.97

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.45 out of 18.57

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.50 out of 21.55

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.18 out of 29.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.34 out of 30.25

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.08 out of 30.22

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.96 out of 32.74

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.60 out of 30.98

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.16 out of 28.19

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.54 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.86 out of 36.53

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.60 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.91 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.42 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 28508 - 79852:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Thr - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

INP57_RS15000: X

AMP-binding (79..468): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: PTIAHTWGLAALFMACSGSYNFYGSTEASWVSIA
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

INP57_RS15085: Thr - X

Search NORINE for peptide: strict or relaxed

AMP-binding (466..877): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGEINMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1528..1918): X

nrpys: Ac-OH-Orn, OH-Orn

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LTQAFDVAFWEMAILCGAELNCYGPTEATVNSTL
Nearest Stachelhaus code(s):: Ac-OH-Orn DVWALGAVNK (74% 8Å match); OH-Orn DVWALGAVNK (71% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism

NZ_JADDUE010000007.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 69,288 - 90,364 nt. (total: 21,077 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

INP57_RS17015: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

INP57_RS17040: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Ligases: synthetase

INP57_RS17045: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001456.3	0.47	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.46	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3	0.44	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.44	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000649.3	0.43	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000648.3	0.42	terpene	carotenoid	Myxococcus xanthus
BGC0000650.3	0.39	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001456.3	0.47	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.46	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3	0.44	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.44	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000649.3	0.43	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000648.3	0.42	terpene	carotenoid	Myxococcus xanthus
BGC0000650.3	0.39	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

INP57_RS17045: PT_FPPS_like

Domain 1 (39 - 339): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.07 out of 20.47

Confidence: medium

Additional weak hits (4):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.48 out of 30.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.96 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.59 out of 24.78

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_JADDUE010000007.1 - Region 2 - CDPS

Download region GenBank file

Download region SVG

Location: 367,601 - 384,845 nt. (total: 17,245 nt) Show pHMM detection rules used

Region on contig edge.

CDPS: CDPS

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

INP57_RS18515: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Ligases: synthase

INP57_RS18510: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

INP57_RS18525: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001948.3	0.49	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000851.5	0.46	other (other)	albonoursin	Streptomyces noursei ATCC 11455
BGC0001986.3	0.45	other (other)	purincyclamide	Streptomyces chrestomyceticus
BGC0000943.5	0.40	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001587.5	0.38	other (other)	ethylenediaminesuccinic acid hydroxyarginine (EDHA)	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002568.2	0.34	other (other)	Ethylenediaminesuccinic acid hydroxyarginine	Streptomyces scabiei 87.22
BGC0002510.2	0.31	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0000896.5	0.31	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0001228.5	0.30	NRPS	retimycin A	Salinispora arenicola CNT005
BGC0002095.3	0.30	NRPS	leupeptin Pr, leupeptin Ac	Streptomyces roseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001948.3	0.49	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000851.5	0.46	other (other)	albonoursin	Streptomyces noursei ATCC 11455
BGC0001986.3	0.45	other (other)	purincyclamide	Streptomyces chrestomyceticus
BGC0000943.5	0.40	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001587.5	0.38	other (other)	ethylenediaminesuccinic acid hydroxyarginine (EDHA)	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002568.2	0.34	other (other)	Ethylenediaminesuccinic acid hydroxyarginine	Streptomyces scabiei 87.22
BGC0002510.2	0.31	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0000896.5	0.31	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0001228.5	0.30	NRPS	retimycin A	Salinispora arenicola CNT005
BGC0002095.3	0.30	NRPS	leupeptin Pr, leupeptin Ac	Streptomyces roseus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.61 out of 30.97

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.69 out of 27.78

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 19.32 out of 33.14

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.62 out of 20.01

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JADDUE010000008.1 - Region 1 - arylpolyene

Download region GenBank file

Download region SVG

Location: 147,547 - 188,707 nt. (total: 41,161 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

INP57_RS19260: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

INP57_RS19280: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

INP57_RS19300: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

INP57_RS19375: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

INP57_RS19380: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

INP57_RS19385: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Hydrolases: glucosidase

INP57_RS19245: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Ligases: ligase synthase

INP57_RS19285: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

INP57_RS19310: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0002276.2	0.54	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002031.3	0.52	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0001310.5	0.51	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0002347.3	0.45	other (other)	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus caeruleus WH1-2216-6
BGC0001868.4	0.45	other (phenazine)	iodinin	Xenorhabdus szentirmaii DSM 16338
BGC0000933.3	0.45	other (other)	xiamenmycin A	Streptomyces xiamenensis
BGC0001483.4	0.44	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0001137.5	0.43	other (other)	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0001529.5	0.43	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0002276.2	0.54	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002031.3	0.52	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0001310.5	0.51	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0002347.3	0.45	other (other)	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus caeruleus WH1-2216-6
BGC0001868.4	0.45	other (phenazine)	iodinin	Xenorhabdus szentirmaii DSM 16338
BGC0000933.3	0.45	other (other)	xiamenmycin A	Streptomyces xiamenensis
BGC0001483.4	0.44	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0001137.5	0.43	other (other)	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0001529.5	0.43	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.60 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.90 out of 28.19

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Additional weak hits (13):

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.81 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.66 out of 29.38

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.76 out of 26.06

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.98 out of 30.22

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.24 out of 28.19

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.14 out of 32.93

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.18 out of 35.63

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.76 out of 23.43

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.18 out of 29.25

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 27.04

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

INP57_RS19285: X

AMP-binding (39..408): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NTVPVTGCNTQVTSGYGGSGNGFGLTETSSIATY
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
IolR	Regulator of the inositol catabolism
ZuR variant 1	Zinc-responsive repressor

NZ_JADDUE010000008.1 - Region 2 - redox-cofactor

Download region GenBank file

Download region SVG

Location: 348,175 - 361,677 nt. (total: 13,503 nt) Show pHMM detection rules used

Region on contig edge.

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: transketolase

INP57_RS20175: transketolase

smcogs: SMCOG1204: transketolase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001100.5	0.35	NRPS, PKS	lankacidin C	Streptomyces rochei
BGC0002007.2	0.31	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0002439.3	0.30	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus
BGC0002300.2	0.28	NRPS	albomycin delta2, albomycin delta1, albomycin epsilon	Streptomyces sp. ATCC 700974
BGC0000273.5	0.25	PKS, saccharide	steffimycin D	Streptomyces steffisburgensis
BGC0000433.5	0.25	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000268.5	0.21	PKS	Sch-47554, Sch-47555	Streptomyces sp. SCC 2136

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001100.5	0.35	NRPS, PKS	lankacidin C	Streptomyces rochei
BGC0002007.2	0.31	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0002439.3	0.30	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus
BGC0002300.2	0.28	NRPS	albomycin delta2, albomycin delta1, albomycin epsilon	Streptomyces sp. ATCC 700974
BGC0000273.5	0.25	PKS, saccharide	steffimycin D	Streptomyces steffisburgensis
BGC0000433.5	0.25	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000268.5	0.21	PKS	Sch-47554, Sch-47555	Streptomyces sp. SCC 2136

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47

Confidence: medium

Additional weak hits (6):

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 24.03 out of 30.12

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.42 out of 26.85

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.35 out of 39.62

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.85 out of 20.01

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: PqqD_RRE; Location: 5 - 86; Score: 74.1

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_JADDUE010000009.1 - Region 1 - amglyccycl

Download region GenBank file

Download region SVG

Location: 155,800 - 176,975 nt. (total: 21,176 nt) Show pHMM detection rules used

amglyccycl: (DOIS or ValA or salQ or strH or strK1 or strK2 or NeoL or SpcFG or SpcDK_glyc)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

INP57_RS20930: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

INP57_RS20935: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

INP57_RS20955: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

INP57_RS20970: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: acyltransferase

INP57_RS20950: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

Hydrolases: amidase hydrolase

INP57_RS20890: amidase

smcogs: SMCOG1105: amidase

INP57_RS20945: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

INP57_RS20960: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: synthase

INP57_RS20920: 3-dehydroquinate synthase

smcogs: SMCOG1183: 3-dehydroquinate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000701.5	0.51	saccharide	jinggangmycin	Streptomyces hygroscopicus subsp. yingchengensis
BGC0000723.5	0.44	other (cyclitol), saccharide	validamycin A	Streptomyces hygroscopicus subsp. limoneus
BGC0001948.3	0.43	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0002621.2	0.42	other (other)	angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine	Streptomyces angustmyceticus
BGC0000722.5	0.42	other (cyclitol), saccharide	validamycin A	Streptomyces hygroscopicus subsp. jinggangensis
BGC0000703.4	0.42	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000713.5	0.41	saccharide	ribostamycin	Streptomyces ribosidificus
BGC0000705.3	0.40	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000720.3	0.39	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000719.5	0.39	saccharide	tobramycin	Streptoalloteichus hindustanus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000701.5	0.51	saccharide	jinggangmycin	Streptomyces hygroscopicus subsp. yingchengensis
BGC0000723.5	0.44	other (cyclitol), saccharide	validamycin A	Streptomyces hygroscopicus subsp. limoneus
BGC0001948.3	0.43	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0002621.2	0.42	other (other)	angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine	Streptomyces angustmyceticus
BGC0000722.5	0.42	other (cyclitol), saccharide	validamycin A	Streptomyces hygroscopicus subsp. jinggangensis
BGC0000703.4	0.42	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000713.5	0.41	saccharide	ribostamycin	Streptomyces ribosidificus
BGC0000705.3	0.40	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000720.3	0.39	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000719.5	0.39	saccharide	tobramycin	Streptoalloteichus hindustanus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.62 out of 27.78

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.91 out of 29.25

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description