LOCUS       NZ_JADDUE010000023     17292 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Saccharopolyspora sp. HNM0986
            NODE_23_length_22551_cov_70.175613_cov_70.175613, whole genome
            shotgun sequence.
ACCESSION   NZ_JADDUE010000023
VERSION     NZ_JADDUE010000023.1
KEYWORDS    WGS; RefSeq.
SOURCE      Saccharopolyspora sp. HNM0986
  ORGANISM  Saccharopolyspora sp. HNM0986
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (bases 1 to 22551)
  AUTHORS   Li,F.
  TITLE     Diversity and distribution of actinomycetes associated with coral in
            the coast of Hainan
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 22551)
  AUTHORS   Li,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2020) chool of Life and Pharmaceutical Sciences,
            Hainan University, 58 Renmin Avenue, Meilan District, Haikou, Hainan
            570208, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 232.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016526145.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 02:15:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,899
            CDSs (total)                      :: 5,838
            Genes (coding)                    :: 5,784
            CDSs (with protein)               :: 5,784
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 7 of 54
            Pseudo Genes (incomplete)         :: 49 of 54
            Pseudo Genes (internal stop)      :: 0 of 54
            Pseudo Genes (multiple problems)  :: 2 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:09:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 17292
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADDUE010000023.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..17292
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..17292
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17292
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[6308:7292](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6309..7292
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            484..1374
                     /locus_tag="INP57_RS28910"
                     /old_locus_tag="INP57_28925"
     CDS             484..1374
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024803.5"
                     /locus_tag="INP57_RS28910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28925"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_200073548.1"
                     /transl_table=11
                     /translation="MGVVLTIGAVAHQLGVAVPTLRSWDRRYGLGPSEHVAGSHRRYTP
                     DDLARLRHMLTLTSEGVPPGVAARLALDSPRFQESMRDGGGSGAVAVGRADRAVRGLAR
                     AATRLDGRTLCSRVAAHIRQRGVRRTWDELLVPLLQTLGEQFDQDTGGRVIGVEHVATT
                     AIVAALHECPLAPERGRIPALLACAPEEQHSLPLEALQASLAERHTASRFLGARVPEPT
                     LISAVRQLAPRSVTVWSHAPRTARKIDLAGLAQECPQLVLAGPGWSSIRPARDHPQPSC
                     LQEAIQVLTEVAAVR"
     misc_feature    complement(1510..1526)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.25"
                     /tool="antismash"
     aSDomain        1563..2030
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_INP57_RS28915_PKS_KR.1"
                     /evalue="8.90E-08"
                     /label="INP57_RS28915_PKS_KR.1"
                     /locus_tag="INP57_RS28915"
                     /protein_end="156"
                     /protein_start="0"
                     /score="24.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="MVTGATGVLGGKIAARLARAGARLAVAGRNEDRLQQASRACEAVA
                     AITFDAGDPDSCTRAVEDAAVALGELDGLVVAHGVAAFGDATEVSNAIAGQVLIVNALA
                     PMALARAALPHLVRGGTIAVVSAVLADYPTAGMSDYSASKGAVSTWLSALRR"
     gene            1563..2240
                     /locus_tag="INP57_RS28915"
                     /old_locus_tag="INP57_28930"
     CDS             1563..2240
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (0-156). E-value: 8.9e-08. Score:
                     24.2. Matches aSDomain:
                     nrpspksdomains_INP57_RS28915_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012334.5"
                     /locus_tag="INP57_RS28915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28930"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_200073549.1"
                     /transl_table=11
                     /translation="MVTGATGVLGGKIAARLARAGARLAVAGRNEDRLQQASRACEAVA
                     AITFDAGDPDSCTRAVEDAAVALGELDGLVVAHGVAAFGDATEVSNAIAGQVLIVNALA
                     PMALARAALPHLVRGGTIAVVSAVLADYPTAGMSDYSASKGAVSTWLSALRRETRRLRI
                     TVCDLRPPHMDTGLADRALAGVAPNLPPAHDSDEIADEIVNALRRGATELFYDPSAQLV
                     QTR"
     CDS_motif       1566..1652
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_INP57_RS28915_0001"
                     /evalue="2.40E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="INP57_RS28915"
                     /protein_end="30"
                     /protein_start="1"
                     /score="17.0"
                     /tool="antismash"
                     /translation="VTGATGVLGGKIAARLARAGARLAVAGRN"
     gene            complement(2559..3806)
                     /locus_tag="INP57_RS28920"
                     /old_locus_tag="INP57_28935"
     CDS             complement(2559..3806)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225918.1"
                     /locus_tag="INP57_RS28920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28935"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_200073550.1"
                     /sec_met_domain="DAO (E-value: 4.5e-12, bitscore: 36.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSLPTADTDVIVVGAGLAGLSAAVRLQEAGCNVRVFEADDDVGG
                     RVRTDVLDGFLLDRGFQLLNPAYPAVRALIDRRALRPHRFWRVLRVVDAGRIRLLGNPF
                     DSPRGVTGLQPPSPVGFRDLAALAALSLRDAAAPARFLTGAADQTTERELRRWGLSERF
                     IDAVLRPFLTGVLAEADLDTSARFFHLVWRSFLRAAPVLPADGMGALSHQLANRLAAGT
                     VTLNARVEDAGPGEVRVAGRRHTTRAVVVATDATAAADLLPTLPIPAWKGLHTFYYRAP
                     EAPLPEPVITVDSRRGPVVNTTIPSNVSSTYAPTEQALISATTLLNADHADTRDAVTAH
                     LAELYRTSTANWDLVGHYPIPHALPRMTAPHRLRTPTRVEPGLYVCGDHRDTSSIQGAL
                     ASGARAARAVSADLAS"
     gene            complement(3941..5437)
                     /locus_tag="INP57_RS28925"
                     /old_locus_tag="INP57_28940"
     CDS             complement(3941..5437)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007034107.1"
                     /locus_tag="INP57_RS28925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28940"
                     /product="cryptochrome/photolyase family protein"
                     /protein_id="WP_200073551.1"
                     /transl_table=11
                     /translation="MTVTPLWLFADQLGPHFHRTEQHRDREVLLVESTAALARHRYHRQ
                     KLHLVLSGLRHLKEELGDRATLIRARTYREALREFRRPVVVHEPNSHAAEELVLSLQRE
                     GLVEAVLPTPAFALPRREFAEWADGRRRFLMEDFYRHQRHRFEILLEPDGGPAGGRWNF
                     DQENRQQPPRAAAELGAPEPWMPTEDDIDREVRADLDTRQQRGELHPIGNDRPRLFPVT
                     SEEAEAAEQRFLDQRLPWFGPYQDAMLDEDWAMAHALLSVPLNLGLLDPLELVRGAEHR
                     YRSEHAPLASVEGFVRQVLGWREYVWHLYWWFGKPYLHRNALRARNKLPKWWSELDGER
                     IEAECLKTAINGVRDRGWAHHIQRLMILSNHGLQREYRPSALNEWFSTAFVDGAPWVMP
                     VNVIGMSQHADGGLVATKPYAAGGAYINRMSDHCKRCPFDPRTRTGEHACPFTAGYWAW
                     LHRKAGDLADNHRMRQPIATMRKLADVEEIAAQESRRRRF"
     misc_feature    5428..5442
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.39"
                     /tool="antismash"
     misc_feature    complement(5428..5448)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.98"
                     /tool="antismash"
     gene            5560..6210
                     /locus_tag="INP57_RS28930"
                     /old_locus_tag="INP57_28945"
     CDS             5560..6210
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS28930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_28945"
                     /product="DUF4383 domain-containing protein"
                     /protein_id="WP_200073552.1"
                     /transl_table=11
                     /translation="MASTSSRRRIHPVHVVHRVGAGAMGLGLWVFAGLGLAHGLPYFST
                     SGQPVVGLSSNGLLSTISLVAGALLISAAVWKGPIASTATAVLGTVFVLSGLAHLAILN
                     TQFNVLAFRLPNVLFSVIAGLILLILGSYGRIAGDLPVDNPYRTERGQTASEFTPGTRG
                     AQEQELVDAELAMAEGHPTRDQEALVHAEQRALRARERARLNDRVRGVDREEN"
     gene            6309..7292
                     /locus_tag="INP57_RS28935"
                     /old_locus_tag="INP57_28950"
     CDS             6309..7292
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016331949.1"
                     /locus_tag="INP57_RS28935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28950"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_200073553.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.4e-48, bitscore:
                     154.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDLHGVPDAEHIADLFADFLAGGKYLRSMFTYIGWRSRAPSSDS
                     ALRAAGSLELLHGFALMQDDVMDGSTIRRGKPAVHVRLAEWHRRRELSGSPERFGASAA
                     VVLGDLALVWAEQMLRHSGLHSAAVDRAWPYYDQMRAELAIGQLADLVNDARRVPSFED
                     VLAVARRKSGNYTVRDPLVLGALLAGCESNVLDVFRVYGSLIGEAFQLRDDLFGIFGRP
                     AVTGKPTGEDLRDRKATTVVVLARELASPHVRAHMDELFAAADLTDADLARSRELIRTT
                     SAEDQVEELITQRVADARRVLSTAAIDETTRTALSDMAMRCTDRDR"
     misc_feature    6489..6491
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7359..7832)
                     /locus_tag="INP57_RS28940"
                     /old_locus_tag="INP57_28955"
     CDS             complement(7359..7832)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658952.1"
                     /locus_tag="INP57_RS28940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28955"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_307850343.1"
                     /transl_table=11
                     /translation="MASKEAVYEIQLSLRRMLQGGREMQSSLARQLGVRVIDVQAVDHV
                     VSAEEPLGPVDLGNRLGIRSASATTLVDRLVAAGHLVREPHPADARRVALRATEHARYE
                     VRQSLTPMLDEITAAIERLDHDQAATVSAFLHEVTAAMRDYAHRPDRTTPEFD"
     gene            7951..8430
                     /locus_tag="INP57_RS28945"
                     /old_locus_tag="INP57_28960"
     CDS             7951..8430
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226321.1"
                     /locus_tag="INP57_RS28945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28960"
                     /product="nitroreductase/quinone reductase family protein"
                     /protein_id="WP_233628738.1"
                     /transl_table=11
                     /translation="MAEQPTAQDARAVNARMVEGLLADPPSPLAQGGYALRVLETRGRR
                     TGDLRRTPLGVVEVAGQRYLVSPNVRRDWVLNLCAQPECALLAGDERERRRAVRVDGAD
                     AVAAVRTYLAALQIPWALQAFPVSADAPQEDVAAHMDEMAVFRLDSPEPGGRGED"
     gene            8430..9725
                     /locus_tag="INP57_RS28950"
                     /old_locus_tag="INP57_28965"
     CDS             8430..9725
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658953.1"
                     /locus_tag="INP57_RS28950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28965"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_200073554.1"
                     /transl_table=11
                     /translation="MNARESGCVVVGGGPGGMVLAYLLGRAGVPVRLLETHRDFDRDFR
                     GDSLHPYTLELLDRLGLADRLLGLPHHKARYFRFHTPAGSVTTADYGKLRTRFNYVALM
                     PQAQLLDFLAAEINEMPGCAVRTGAKVTDLLRNDSGRITGVRYRDSAGAHEFAAAVVIG
                     ADGRFSKLRRLVGAQAHSLGATTDLLWFRLPRRQDDPPEADVDLYFGRDHYVGLLAGTQ
                     GWQVGYSLPKGGYAAAREAGVEPIREFVADRVPWLADRVHLLTDFTATTLLSVDIARVE
                     QWWRPGLLLIGDAAHVISPVGGNGILMAVQDAVTAAEHLADTLRNGRPVSDDVLRAIQA
                     EREPAIRHVQRDQVRTEQRAARARGTGRPIGPPRLLKLVTALPGVRARAAASNAYGPDP
                     PRLSGLFDTAPPRPRRGRIDAAGAELTRRHRS"
     gene            9729..11111
                     /locus_tag="INP57_RS28955"
                     /old_locus_tag="INP57_28970"
     CDS             9729..11111
                     /EC_number="4.1.99.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003904 - deoxyribodipyrimidine
                     photo-lyase activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020500237.1"
                     /locus_tag="INP57_RS28955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28970"
                     /product="deoxyribodipyrimidine photo-lyase"
                     /protein_id="WP_200073555.1"
                     /transl_table=11
                     /translation="MPDTAIAVLTRDLRVHDNPVLAAAAESARQVVPLFVHDAALAKTG
                     FASAPRTRFLQECLADLDAGLRRRGAALVVREGDLVTEVGRLAEEVDAASVHIAADVSG
                     FAARRERRLTEELGARRRPLTVHGAVHTVLAPGAATPQGNDHFAVFTPYHRRWAEIDHR
                     PLAALPRRFSLPASLPKPSPPGEADTGSTMRGGESQARRRAHQWLQEHSDEYHYGQDRL
                     AAEDGTSRLSPYLHFGCVSARELAAVAADRATVGAEAFVRQLAWRDFHHQVLAARPEAA
                     RRDYRPRGDEWRDDEHALRAWQEGRTGIPIVDAGMRQLLTEGWMHNRARLITGSFLTKT
                     LYIDWRAGAVHFLRHLLDGDVANNQMNWQWVAGTGTDTRPNRVLNPLRQAERYDPDGTY
                     VRRWIPELAVLDDPRELHQPWRLGTNMLNSLGYPAPIVDLDAARERFQQHRQRANRGTS
                     SQ"
     misc_feature    11240..11253
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.36"
                     /tool="antismash"
     gene            11320..11961
                     /locus_tag="INP57_RS28960"
                     /old_locus_tag="INP57_28975"
     CDS             11320..11961
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS28960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_28975"
                     /product="hypothetical protein"
                     /protein_id="WP_200073556.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.2e-07, bitscore:
                     21.6, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTADARTAESYQDTFVAGLENLLGAIAEQVPATPRTLLVSSTSV
                     YGVSDGSRVDERTPASPGTSTGRVLRRAEELLHARLPGATVLRLGGLYGPGRGTLLSTV
                     SGGTATLTRTPVYTNRIHRDDAAAAIAHLTTRGPAPEPVYLGVDDEPCARAELLRFLAD
                     ELGVAHPPVVEERSGRGQGKRCSNERLRATGFTFAYPTYREGYRALISAR"
     gene            12078..12617
                     /locus_tag="INP57_RS28965"
                     /old_locus_tag="INP57_28980"
     CDS             12078..12617
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013868.5"
                     /locus_tag="INP57_RS28965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28980"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_200073557.1"
                     /transl_table=11
                     /translation="MKIPQRMSAVRSRLTAVELSGSESGDARLSQRGKDEIALNICERT
                     PHGESALVASGTGSPLGLHVSRPKQDVAVVVASGDIDDATITRFEEIVLARLRAALRVV
                     VLDLSRVHFLGVAGLKALRTAQLLAQQRNVRLHLVATDHEVLRALHTAELGEVLPVHAT
                     VPAALGELDVQGESAG"
     gene            complement(12715..13845)
                     /locus_tag="INP57_RS28970"
                     /old_locus_tag="INP57_28985"
     CDS             complement(12715..13845)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009946651.1"
                     /locus_tag="INP57_RS28970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28985"
                     /product="hypothetical protein"
                     /protein_id="WP_200073558.1"
                     /transl_table=11
                     /translation="MRLGFLQDAYEQEGPFATVYLDTSADAEDAGKAIALRWRSAREQL
                     AGAGADEDTLRLIDDELETPQQRTGHRGEVVVANANGIVFSDELPERPGDLTDDERTTY
                     GPVPDLFPYLRMRGARIPHVVAVVDRQGADITTVQATLRAQDAAVEGEDTLLHKDGSGG
                     GAGSEQRQQNAVEEHRKHNAGQVADEISKRAAAIGAEAIVLAGDPQQRELVRQDVRKGM
                     QPLVVETEASHRDRNASGESLQQAVSETVEATLTERVDAVVSEFERERGEHARASEGWE
                     STVAALQRGQVATLLRAVPDSAEQPANLHIGPSAADIGTTRAALTDAGVQHVREAPADS
                     AVVRALAGTDAALVLVDPAKVSLADGIGAVLRYTES"
     misc_feature    complement(14024..14043)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: strong, score: 26.87"
                     /tool="antismash"
     gene            14158..14301
                     /locus_tag="INP57_RS28975"
                     /old_locus_tag="INP57_28990"
     CDS             14158..14301
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011873984.1"
                     /locus_tag="INP57_RS28975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28990"
                     /product="hypothetical protein"
                     /protein_id="WP_233628739.1"
                     /transl_table=11
                     /translation="MPVTELAVAGGAEVTEQADEELLAAGWTRSADWSTADDGWLAPVV
                     PS"
     gene            complement(14384..14779)
                     /locus_tag="INP57_RS28980"
                     /old_locus_tag="INP57_28995"
     CDS             complement(14384..14779)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021536.5"
                     /locus_tag="INP57_RS28980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28995"
                     /product="DUF2267 domain-containing protein"
                     /protein_id="WP_200073560.1"
                     /transl_table=11
                     /translation="MNYDEFLTRVGQRGGPTEREHADAATKQILAAVGQRLAGNEPRDL
                     ASQLPAELQAPLLRPTGQAEIGDDLDDFLRRVSDREGRGCTTEQALTHARAVLSSIAEF
                     VSAGEIHDLRSQLPTGYAPLFESPQQS"
     gene            complement(14826..15725)
                     /gene="thpD"
                     /locus_tag="INP57_RS28985"
                     /old_locus_tag="INP57_29000"
     CDS             complement(14826..15725)
                     /EC_number="1.14.11.55"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013230318.1"
                     /locus_tag="INP57_RS28985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_29000"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_200073561.1"
                     /sec_met_domain="PhyH (E-value: 1.6e-30, bitscore: 97.4,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVIHTKVADRYPTRSSARSAIFPRRDPVVWSDPAAGPADSDQLL
                     AHQRSGFHAVDLLSPGEVQHHWRELERLTADPQVRADERTVVEKGTDEVRSIFDVHHLS
                     PAIVDLVHDPRVLDRARQILGSEVYVHQSRINYMPGFRGGGFYWHSDFETWHAEDGMPA
                     PRAVSLSIALTDNYPFNGGLMLMPGAHRSFVSCAGETPAENYKSSLVEQRAGVPGENDI
                     TRLAYEHGIEQFTGPAGSALWFDSNSMHGSGNNITPFPRSNIFIVFNSVHNTLDEPFAA
                     KHPRPEFVASRDFEPVWR"
     gene            16180..16914
                     /locus_tag="INP57_RS28990"
                     /old_locus_tag="INP57_29005"
     CDS             16180..16914
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024583.5"
                     /locus_tag="INP57_RS28990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_29005"
                     /product="GAF and ANTAR domain-containing protein"
                     /protein_id="WP_200073562.1"
                     /transl_table=11
                     /translation="MNAEHPARRVEDVTDAFDQLSALLDRFESLDTVLTRLTDSALATI
                     PDTGSASVTVLRHEHARTAAATHPWAAELDEHQYSAEDGPCLHAARTGRLVRLDTAETD
                     RWPEFSRAARDQDVAVAVGVPLLIDDDIVNTSAALNLTTPQHQAFDPLDEALLELFTHA
                     LSTAINHAYRHQQARRLADQLGDALDNRDVIGQAKGLLMARHHCGPEQAFDYLRTASQQ
                     SNVKLRDVAARLVAGETANHRD"
ORIGIN
        1 aactctaccg cgtgattgcg atactcggca gtgtacctcc ggcgcgacgc cgccatcatc
       61 cacctctttc acagacagtc gatcactact ctcggctgtc cgccaaagcg ggaacggtcc
      121 acgaggcggc cctaacaagg acggcgcatt gacgcggcct tctgattacg cccgtacccg
      181 gccgggctcg ggacgaatcg cggcgtcgac cgtggtacct gccacgtcgg cgacgtcatc
      241 gaaccggatc gacgaatggt cgaccggtag ccaggccgtc gagcagtgca gagccgatgc
      301 aactgccggt gcgctcaccg gcggcttcga gtgaacctga tgttgttctg ccacggagct
      361 cccagcacgg ccgagagccc cggtggcaga gcaatcggac taccgttggc aggcaaagca
      421 gtggaccggc gcgtccgatg acgaggattg ccgttgggga gagatgtgtc ggcggtgaat
      481 gaaatgggcg tggtgctcac catcggtgct gtggcgcatc agctcggggt ggcggtgccg
      541 acgctgcgca gctgggacag gcgctacggc ctagggccga gcgaacatgt tgccgggagt
      601 catcgtcgct acacgccgga cgatctggcc cggctgcgcc acatgctgac gttgacgagc
      661 gaaggcgttc cgcccggcgt tgccgcccgg ctggcgctcg attcgccacg ttttcaggaa
      721 tcgatgcggg atgggggtgg atccggcgct gttgcggttg gccgtgccga ccgcgccgtt
      781 cgtgggctgg ccagggcggc cactcgtctc gatgggcgca ccctgtgttc tcgagtcgca
      841 gcgcacatca ggcagcgggg cgtgcgacgg acttgggatg aactgctcgt tccgttgttg
      901 cagaccctgg gcgagcaatt cgaccaggac accggtggcc gcgtcatcgg tgtcgagcac
      961 gtcgctacga ccgcaatcgt ggcggccctg cacgagtgcc cgcttgctcc tgaacggggc
     1021 cggatccccg cgctgctggc gtgtgcaccg gaagaacagc acagcctgcc gttggaagcg
     1081 ctgcaagcgt cgctggccga gcggcacacc gcatccaggt tcctcggcgc ccgggtcccc
     1141 gagccgacct tgatctctgc tgtgcgccaa ctggctccac gaagcgtcac ggtgtggtcg
     1201 cacgctccgc gcacagcgcg gaagatcgac ctggcaggtc tcgcacagga gtgccctcag
     1261 ctggtattgg ccgggcccgg atggtcgtcg atccggcctg cccgcgacca tccacagccg
     1321 agctgcttgc aagaggcgat tcaggtcctc acggaggttg ccgcagtgcg ctgataagcc
     1381 gaacgcttac gcgaggaacg cgcctggcgc accaaccgca tgccggtgat gcgccgaggt
     1441 acgagatcga gctgcagcgg agctgcgatc atcaaagtct ctgcccatcc tggccggatc
     1501 cgcgcaaagc gcgccggaca agtgcatgcg ggggcggtat ggaactgagc ggagctcgga
     1561 tcatggtcac cggagcgacc ggcgtgctcg gtggcaagat cgcggcccgg ctcgcgcggg
     1621 caggagcccg cctggccgta gcaggcagga acgaggatcg cttgcagcag gcgagccgcg
     1681 cctgcgaggc ggtggcagcg atcacgttcg atgcgggaga tccggacagc tgcactcggg
     1741 cggtcgagga cgctgctgtg gcgctcggag agctcgacgg gctggtcgtc gcgcacggcg
     1801 tcgccgcgtt cggcgacgcc accgaggtga gcaatgccat cgccggccaa gtgctcatcg
     1861 tcaatgccct ggcgccgatg gcgttggccc gtgcggcact gccgcacctc gtacgcggcg
     1921 gcacgatcgc tgtggtttcg gcggtgctgg ccgattaccc cactgcgggc atgagcgact
     1981 actcggcgag caaaggggcg gtgtcgacgt ggttgtccgc attgcgacgg gaaacccggc
     2041 gcttgcgcat caccgtgtgc gatctgcgtc cgccgcacat ggacacgggt ttggccgatc
     2101 gagctctcgc gggcgtggca ccgaatttgc ctcccgcgca cgattccgac gagatcgccg
     2161 atgagatcgt caacgcgctg cggcgcgggg cgacagaact gttctatgac ccgtcggccc
     2221 agctggtgca gacccgctag caacgcaacg tgctcgcgga gtctcttcga tcgagtggtg
     2281 gccgcccggg tgctctgtcc tgggcggcca ccgcgacgtc ggttacgtga ttgcggtggc
     2341 atcaggcacg tcaccgctcg tgccacgcag aatcactcgg aacctccgtc agcaacagag
     2401 gttagtccct gcagaggcag acggatcggc aggcgctgtc gctcgttcga gcgcaccgca
     2461 caacattttg ttgtgtcgag caggctcagt gcggccgctg aggtgcctgt gctggcgtag
     2521 cgaacggttt gtgggggaag gcggcgttgc ccggatgatc acgatgcgag gtcggctgac
     2581 acggctcggg ccgcgcgtgc accggaggcc agggctcctt ggatggagct ggtgtcccgg
     2641 tggtcgccgc acacgtacag ccctggttcg acacgtgttg gagtgcgcag tcggtgcggc
     2701 gcggtcatgc ggggcagagc gtgcgggatc gggtagtggc cgacgagatc ccagttcgca
     2761 gtgctcgttc ggtacagctc ggccaggtgc gccgtgaccg cgtcgcgggt atccgcgtgg
     2821 tcggcgttga gcagggtcgt ggcgctgatc agcgcttgtt ctgtgggcgc gtaggtgctg
     2881 gacacgttgg acgggatggt tgtgttgacg accggtccgc ggcgggagtc gacggtgatg
     2941 accggttcgg gcagcggtgc ctccggcgcg cggtagtaga aggtgtggag gcccttccag
     3001 gcggggatcg gcagggtggg cagtaggtct gcggctgcgg tggcgtcggt ggccacgacg
     3061 acggcacgcg tggtgtggcg tcgtccggcc acccggactt cgccgggacc ggcatcctcg
     3121 actctggcgt tgagcgtcac cgtgccagcg gcgaggcggt tggcgagctg gtgcgacagc
     3181 gctcccattc cgtcggcggg caacaccggg gccgcacgca ggaaactgcg ccagaccagg
     3241 tggaagaagc gcgctgaggt atccaggtcg gcctcggcga gcaccccggt cagaaacggc
     3301 cgcaacaccg catcgatgaa ccgctcggac aggccccacc gtcgaagttc gcgttcggtg
     3361 gtttggtcgg cggctccggt gaggaatcgg gcgggcgcgg cggcgtcgcg cagtgagagc
     3421 gccgccaggg cagccaggtc gcggaaaccg accgggctcg gtggctggag tccggttacg
     3481 cctcgggggc tgtcgaacgg gttgccgagc agccggatcc gcccggcatc gacgacgcgg
     3541 aggactcgcc aaaatcggtg gggccgcaga gcacgccggt cgatcagcgc ccgtacggcg
     3601 ggataggcgg gattgagcag ctggaacccg cggtcgagca ggaaaccatc gagcacgtcc
     3661 gtgcgcaccc gaccgccgac atcgtcgtcg gcttcgaaga cccgcacatt gcagccggct
     3721 tcttgcaggc gcacagcggc cgacagcccg gccaggcctg cgccgaccac gatgacatcg
     3781 gtgtctgctg tcggaaggga gggcatcgcg tctccttgtg atgcgaaatg ttcgggcatc
     3841 gttcagcgtg cggcagacct ccgcggcgcg gcacgtgctg gcggggatac cggtcgagcg
     3901 cgcagcgagc ggagctctga acaagtactc cactgtggac tcagaagcgg cgtcgccgtg
     3961 attcctgcgc ggcgatttcc tcgacgtcgg cgagcttgcg catggtcgcg atgggctggc
     4021 gcatccggtg gttgtccgcc aagtcgcctg ctttgcggtg cagccacgcc caatatccgg
     4081 ccgtgaacgg acacgcgtgc tcgccagtgc gcgtgcgggg atcgaacggg caccgcttgc
     4141 agtgatcgct catgcgattg atgtaagcgc cgccggccgc gtagggcttg gtggcgacca
     4201 gaccgccgtc ggcgtgctga ctcatgccga tcacgttgac cggcatgacc catggtgcgc
     4261 cgtccacgaa cgcggtcgag aaccactcgt tcagcgcgct cggccggtat tcccgctgta
     4321 ggccgtggtt gctcaggatc atgagtcgtt ggatgtggtg cgcccatccg cggtcgcgga
     4381 ctccgttgat cgcggtcttc aagcactccg cttcgatgcg ctcgccgtcc agttcggacc
     4441 accacttcgg gagtttgttg cgtgctctca acgcattgcg gtgcaggtac ggcttaccga
     4501 accaccagta gaggtgccag acgtactcgc gccatccgag cacttgccgg acgaagcctt
     4561 ctacgctggc cagcggcgcg tgctcgctgc ggtaacggtg ctcggcgccg cgcacgagtt
     4621 cgagcgggtc cagcaatccg aggttcagcg gtacggacag cagggcgtgg gccatggccc
     4681 agtcctcgtc gagcatcgcg tcctggtaag gaccgaacca cggtaggcgc tgatcgagga
     4741 accgttgctc ggcagcttcg gcctcctcgc tggtcacggg aaacagccgc ggacggtcgt
     4801 ttccgatcgg gtgcagctcg ccgcgctgct gccgggtgtc gaggtccgca cgtacttcgc
     4861 ggtcgatgtc gtcctcggtc ggcatccagg gttccggcgc gccgagttct gccgctgccc
     4921 gaggcggctg ctgccggttc tcctggtcga agttccacct gccgccggcc gggccgccgt
     4981 cgggctccag caggatctcg aatcggtggc gctggtgtcg gtagaagtcc tccatcagga
     5041 agcggcggcg cccgtcggcc cactcggcga actcgcggcg cggcagtgcg aaagcgggcg
     5101 tcggcagcac cgcctccacc aggccttcgc gttgcagcga caacaccagt tcctcggctg
     5161 cgtgggagtt cggctcgtgg acgactaccg gtcggcggaa ctcgcgcaac gcctcccggt
     5221 aggtacgagc gcggatcagc gtggcgcggt cgccgagttc ctccttgagg tggcgcaagc
     5281 ccgacagcac gagatgcagt ttctgccggt ggtagcggtg tcgtgcgagg gcggcggtgg
     5341 actcgaccag caacacttcc cggtcgcggt gctgttcggt gcggtggaag tgcgggccga
     5401 gctggtcggc gaacaaccag agcggggtaa ccgtcatttt cacgatgttc ctagccgacg
     5461 cggctgcccg cgtgctggat cgctgcgagt tgcactggtt ttgcatcgtt cctaccgtga
     5521 acacggtttg aagcctgctc cggtggggag gcgagcacca tggcgagcac gagttcccgg
     5581 cgacggattc atccggtgca cgtcgtgcac cgtgttgggg cgggtgcgat ggggctgggg
     5641 ctgtgggtgt tcgcggggct gggattggcc cacggcttgc cgtacttttc gacgtccggt
     5701 cagcctgtgg tcggcctgtc cagcaatggg ctgttgtcga ccatctcgtt ggtagcgggg
     5761 gctttgctga tctcggcagc ggtgtggaaa ggccccatcg cctccacggc gacggcagtc
     5821 ctcggaaccg tcttcgtgtt gtccggcctc gcacatctgg cgatcttgaa cactcagttc
     5881 aacgtgctcg cgttccggct gccgaacgtg ctcttcagcg tgatcgccgg cttgatactg
     5941 ctgatcttgg ggtcctacgg ccggatcgcg ggcgatcttc cagttgacaa cccttaccgg
     6001 accgaacgcg gacagaccgc atccgagttc acaccgggca ctcgtggtgc gcaggagcag
     6061 gaactcgtgg acgctgagtt ggcaatggcc gaaggccatc ccacccgcga ccaagaagcc
     6121 cttgtccacg ccgagcaacg cgcgctgcgc gcccgcgagc gggcgcggtt gaacgaccgc
     6181 gtgcgcggcg tcgatcgtga ggagaattga tcaccgcgga accgaaccga tcggagctgg
     6241 gcggcgagca tgacgcggta cgtcggcgga tcgcggcgca cgtccaggat ttcgtgaagg
     6301 accgatgcat gcgggatctc cacggggtac cggacgccga gcacatcgcc gacctgttcg
     6361 cggacttcct cgccggtggc aagtacctgc ggtcgatgtt cacctacatc ggctggcgga
     6421 gccgtgcccc tagcagtgac agtgcgctgc gcgccgcagg cagtctggag ctcctgcacg
     6481 ggttcgcgtt aatgcaagac gacgtcatgg acgggtcgac cattcgccgt ggcaagccgg
     6541 ccgtacacgt gcggcttgcc gagtggcatc gtcgaagaga gttgtccggc tcgccggagc
     6601 ggttcggtgc ttccgcggcg gtcgtgctcg gcgacctggc gctggtgtgg gccgagcaga
     6661 tgctgcggca cagcggcctg cactcggccg ctgtcgatcg agcgtggcca tactacgacc
     6721 agatgcgcgc tgagctggcc atcggacaac tcgcggacct ggtcaacgat gcccgccgcg
     6781 tcccgagttt cgaggacgtg ctggcggtcg cccggcgcaa gtcggggaac tacacggtcc
     6841 gtgacccact cgtgctcgga gcgctgctcg cgggctgcga gtcgaatgtg ctcgatgtct
     6901 tccgcgtcta cggaagcctg atcggtgagg cgttccagct tcgggacgac ctgttcggga
     6961 ttttcgggag acccgcggtc acgggaaagc cgaccggaga agacctgcgg gaccgcaagg
     7021 ccaccactgt cgtcgtcctc gcccgcgaac tcgcatctcc gcacgtgcgc gcgcacatgg
     7081 acgagctgtt cgccgccgct gatctcaccg atgccgatct cgcgcgatcg cgagaactga
     7141 tccgcaccac gtccgcggag gatcaggtgg aggagctcat cacacagcgc gttgcagacg
     7201 cacggcgtgt cctgtccacc gcggcgatcg acgagacgac cagaacagcc ctgtcggaca
     7261 tggccatgcg atgcaccgac cgcgaccggt agggcgggtt gtgtcgtgcc ggatgcgggt
     7321 agcggcgggc cgacgcaacc gctgcgccgc cccggagttc agtcgaactc cggggttgtg
     7381 cgatcaggcc ggtgggcata gtcgcgcatg gcagcggtga cctcgtgcag gaaggcggac
     7441 accgttgcgg cttggtcgtg gtcgagtcgt tcgatggccg cggtgatctc gtcgagcatc
     7501 ggcgtgagcg actggcgcac ttcgtaacgg gcgtgttcgg tggcgcgcag cgcgacgcgg
     7561 cgtgcgtcgg cggggtgcgg ttcgcgtacc aggtgtccgg ccgcgaccag ccggtcgacg
     7621 agcgtggtgg ccgatgccga ccggattccc agccggttgc cgaggtcgac gggtccgagc
     7681 ggttcctccg cggacacgac gtggtcgacg gcttgcacat cgatcacgcg cacacccagc
     7741 tgcctggcca gcgaactctg catttcccgc ccgccctgca acatgcgccg cagcgacagc
     7801 tggatctcgt agacggcttc cttgcttgcc acgcaccgat gctagctaga aaagcgagca
     7861 gagtcgcatc tcgggaggtg gctagaaaaa cgagcgacct gtaggttgca ggtgttagct
     7921 agaaaaacga gtgaagttgg atggtgcagc atggcggagc agccgaccgc gcaggacgcc
     7981 cgagccgtca atgcccgcat ggtcgagggg ttgctggccg acccgccaag cccgctggcg
     8041 cagggtggtt atgcgctgcg tgtgctggag actcgggggc gccgcacggg tgatctacgg
     8101 cgcaccccgc tcggtgttgt cgaggtggcg gggcagcggt acttggtgtc gccgaatgtc
     8161 cggcgggatt gggtgctgaa cttgtgcgcg cagccggagt gcgcgctgct ggcgggagat
     8221 gagcgggaac gtcgccgggc ggttcgcgtc gatggcgcgg atgcggtcgc cgcggtgcgg
     8281 acgtacttgg ccgcgttgca gatcccatgg gcgctgcagg cgtttccggt ttcggccgac
     8341 gcgccgcagg aggacgtcgc ggcgcacatg gacgagatgg cggtgttccg cctcgactcg
     8401 cccgagcccg gcggcagggg tgaggactga tgaacgcccg ggaatccggt tgcgtcgtgg
     8461 tcggtggtgg cccgggcggc atggtgctcg cctacttgct gggccgtgca ggtgttccgg
     8521 tgcgtctgtt ggagacgcac cgcgacttcg accgggactt ccgtggcgac tcgctgcacc
     8581 cttacacctt ggagttgctc gaccggttgg ggctggccga tcgacttctc ggcctgccgc
     8641 atcacaaggc gcggtacttc cggttccaca ctccggccgg gtcggtgacg accgccgatt
     8701 acggcaagct gcgcacgcgg ttcaactacg tcgccttgat gccgcaggcg cagctgctgg
     8761 acttcctcgc cgctgagatc aacgaaatgc ccggctgtgc ggtgcgcacc ggcgccaaag
     8821 tcaccgactt gctccggaac gacagcggtc gaatcaccgg tgtgcgctac cgcgacagcg
     8881 ccggtgcgca tgagttcgcc gccgctgtgg tgatcggcgc tgacggccgg ttctccaagc
     8941 tgcggcggct cgtcggcgcg caggcgcact cgctgggtgc caccacggac ctgctgtggt
     9001 tccggctgcc gcgccggcag gacgatccac cggaagccga cgtcgatttg tacttcggcc
     9061 gcgaccacta cgtcggtctg ctggcgggca cccagggatg gcaggtgggc tacagcctcc
     9121 cgaagggcgg ctacgcggcc gcccgcgagg ccggggtcga gccgatccgg gaattcgtcg
     9181 cggatcgcgt gccgtggctg gccgaccgcg ttcacttgct caccgatttc accgcgacca
     9241 cgctgctgtc ggtggacatc gcccgtgtcg agcagtggtg gcggccgggg ttgctgctca
     9301 tcggagatgc cgcgcacgtc atctcgccgg tcggcggcaa cgggattctc atggccgtcc
     9361 aagatgccgt cacggctgcc gagcacctcg ccgacacgct gcggaacggt cggccggtat
     9421 cggacgatgt gctgcgtgca atccaggccg aacgcgaacc ggccatccgg catgtgcagc
     9481 gcgaccaggt ccggacagag caacgagcgg cccgcgcacg cggcaccgga cgtccgatcg
     9541 gcccgcctcg gctgctcaag ctcgtcaccg cgctgccggg cgttcgggcg cgtgccgcgg
     9601 cctccaacgc ttacggaccg gacccgcccc ggctctccgg cttgttcgac acggcaccac
     9661 cacgcccgcg tcgggggaga atcgatgcag cgggcgcgga actgactcgc cgacacagga
     9721 gctgatcgat gccggacaca gcgatcgcgg tgctcacccg ggatctgcga gtgcacgaca
     9781 atcccgtgct ggctgcggct gccgagtccg ctcggcaggt cgtgccgctg ttcgtccacg
     9841 acgccgcgct ggccaagacc ggattcgcat ctgcaccccg aacgcggttt ttgcaggagt
     9901 gcttggccga tctcgacgcg gggttgcgcc ggcgaggggc cgcgctcgtc gtccgagaag
     9961 gtgatctcgt caccgaagtc gggcggctcg ccgaggaggt cgatgccgct tcggtgcaca
    10021 tcgccgccga cgtgtccggc ttcgccgcgc gccgcgaacg ccggctcacc gaggagctcg
    10081 gcgcccgccg acggccgctg accgtgcatg gcgcggtgca caccgtgctg gcgcccggtg
    10141 cagcgactcc gcaaggcaac gatcacttcg cggtgttcac gccgtatcac cggcggtggg
    10201 ccgaaatcga ccaccgcccg cttgccgccc tgccgcgccg cttctcgctg cctgcgagct
    10261 tgccgaaacc gtctccgccc ggcgaggccg ataccgggtc gaccatgcgc ggcggggaaa
    10321 gccaagcacg gcgccgagcg catcagtggc tgcaggagca ctccgacgag taccactacg
    10381 ggcaggaccg tctcgccgcc gaagacggaa cgtcccggtt gtcgccctac ctgcacttcg
    10441 gatgcgtgtc cgcgcgggag ctcgccgcgg tcgcggccga tcgagccacc gtcggcgcgg
    10501 aggccttcgt gcgccagctc gcctggcgcg atttccacca ccaagtgctc gcggcccgcc
    10561 ccgaggccgc acgccgcgac taccggccgc gtggcgacga gtggcgcgac gacgaacatg
    10621 ctctgcgggc gtggcaggag gggcgcaccg gtatccccat cgtcgatgcc gggatgcggc
    10681 agctgctgac cgaaggctgg atgcacaacc gagcccggct gatcactgga agcttcttga
    10741 ccaagaccct ctatatcgac tggcgcgcgg gagccgtgca ctttctgcgc cacctgctcg
    10801 acggcgatgt ggcgaacaac cagatgaact ggcaatgggt cgccggcacc ggtaccgaca
    10861 cgcgcccgaa ccgggtgctc aacccgctgc gccaggccga gcgctacgac ccggacggta
    10921 cctacgtgcg ccggtggatt ccggaactcg cggtcctcga cgacccgcgc gagctgcacc
    10981 agccgtggcg gctcggcacc aacatgctga actcgctcgg ttaccctgcc cccatcgtcg
    11041 atctcgacgc cgcccgcgag cgtttccagc agcaccggca acgcgcgaac cgaggaacat
    11101 ccagccagtg acaccggatc agcacgaccg tcccacggcg gtgatcgcag gatgcggcga
    11161 cctgggcggc caggtcggac tgcgtctggc ggcgagcgga caccacgtgg tcgggctgcg
    11221 ccgccgcgcg gaccgggtct ggacccgatc gaaggacgtg cgatcgacat caccacgcag
    11281 tcgccccgcc tgccgcagga caccgccatc gtggtcgtgg tgctcacggc cgacgcccgc
    11341 accgcggagt cctaccagga cactttcgtc gccgggctgg agaacctgct cggcgccatc
    11401 gccgagcagg ttcccgcaac gccgcggaca ttgctggtgt cgtccacctc ggtctacggc
    11461 gtctccgacg gaagccgggt cgacgaacgc acgcccgcct cgccgggcac atccaccggg
    11521 cgcgtgctcc ggcgagccga ggagttgctg cacgcgcggc tacccggcgc caccgtgttg
    11581 cggttgggcg ggctgtacgg ccctgggcgg ggcacgctgc tgtcgaccgt cagcggcggc
    11641 accgcgacgc tgacgaggac tccggtctac accaaccgga tccaccgcga cgacgcagcg
    11701 gccgccatcg cgcacttgac cacccgcggc cctgctccgg agccggtcta cctcggcgtc
    11761 gacgacgagc cttgtgcacg ggcggagttg ttgcgcttcc tggccgacga actcggcgtc
    11821 gctcatccgc ccgtcgtcga ggaacgatca gggcgcggac agggcaagcg atgcagcaac
    11881 gaacggctca gggccaccgg attcaccttt gcttacccca cgtaccgcga gggttaccgc
    11941 gcgttgatct ccgcgcgctg accggtcccg catcagctcg cgccctacag gaatcggcct
    12001 tcaggcaggc ggaagacttc gctgcggtcc ggtcgtccgg tacggtcgga gtttcggttg
    12061 agcagtcagc caggaccatg aagatcccgc agcggatgtc cgcggtccgg tctcggttga
    12121 ctgctgtaga gctttccgga tccgagagtg gcgatgcgcg gctttcccag cggggaaagg
    12181 acgagatcgc attgaacatc tgtgaacgaa cgccgcacgg ggaatccgcc ctcgtcgcgt
    12241 ccggcaccgg ctcgccgctc ggcttgcacg tatcccggcc gaagcaggac gtcgctgtcg
    12301 tcgttgcctc cggcgatatc gacgacgcga ccatcacccg tttcgaagag atcgtgctgg
    12361 cgcgcctgag agccgcactg cgcgtggtgg tgctcgacct gagccgcgtg cacttcctcg
    12421 gcgtcgcagg gctgaaagcg ttgcggacgg cgcagctgct cgcccagcaa cgaaacgtgc
    12481 ggttgcacct cgttgccacc gaccacgaag tgctgcgggc gctgcacact gccgagttgg
    12541 gcgaggtact tccggtacac gccacggtgc cggctgcttt gggcgaactc gacgtgcaag
    12601 gggaatcggc tggatgagcg ggtgcttgcg caccgcgacc gcgttcgcac tgcgctgcct
    12661 gccgcgcaaa aacgccggtt ccgctccggg gagcggaacc ggcgaggcga tgtgtcagct
    12721 ttcggtgtag cgcaggaccg ccccgatccc atcggcgagc gagaccttcg ccgggtcgac
    12781 gagcacgaga gcggcgtcgg tgcctgccag cgctcgcacg acggcggagt cagcgggcgc
    12841 ctcccgcacg tgttggaccc cggcatcggt cagcgcggct ctggtggtgc cgatgtcggc
    12901 ggccgacggt ccgatgtgga ggttcgcagg ctgctcggcg gagtccggga ccgcgcgcag
    12961 caacgtggcc acctggccgc gctgcagagc ggccactgtg gactcccatc cctccgaggc
    13021 gcgggcgtgc tcgccccgct ctcgttcgaa ctcgctgacg accgcgtcga cgcgttcggt
    13081 gagggtcgct tcaaccgtct cggaaacggc ctgctgcagg ctttccccgg aggcgttgcg
    13141 gtctcgatgg ctcgcctcgg tttccacgac cagtggctgc atccccttgc ggacgtcctg
    13201 ccggacgagt tcgcgttgct gcggatcgcc ggcgagcacg atcgcctcgg caccgatcgc
    13261 cgcggcgcgc ttggaaatct cgtctgcgac ctgtccggcg ttgtgcttgc ggtgctcttc
    13321 caccgcgttc tgctggcgct gttcgctgcc tgcgccgccg ccgctgccgt ccttgtgcag
    13381 cagcgtgtcc tcgccctcca ccgcggcgtc ctgagctcgc aaggtggcct gcaccgtggt
    13441 gatgtcggcc ccttgccgat cgaccaccgc gacgacgtgc gggatgcgcg ccccgcgcat
    13501 ccgcaggtac gggaacaggt ccggcaccgg gccgtaggtg gtcctttcgt cgtcggtgag
    13561 gtcgccgggg cgctccggca gctcgtcgga gaaaacgatg ccgttcgcgt tcgccacgac
    13621 cacttcaccg cggtggccag tgcgctgctg cggggtttcg agttcatcgt cgatgagccg
    13681 caaggtgtcc tcgtcggctc ctgcgccggc gagctgttcg cgagcggatc gccagcgcag
    13741 cgcaatggcc ttgcccgcgt cctcagcatc tgccgaggta tccaggtaca ccgtcgcgaa
    13801 cggcccctcc tgctcatacg catcttgcag gaagccaagc cgcaaaacga actcctttcg
    13861 ccatcaccga tctggactac tcgtgctgct acccggccgg cgcttcgatg aaacccgccg
    13921 gctgactcga tgtttgccga tgctgcctgc ggggcagatc agaccggttg ggagaagtcc
    13981 ggtgaccgaa cgacgtcgcg acccggcacc ctcccgcgga gttcccgggg cgaaagtccc
    14041 cgcacgccgg aagattccag cagctgacat gaggaggacg agcagatggc caacaacgcg
    14101 catctgatcc acgcgaccga cggcaggtcg accgtcgtcg ttcgagacga tcgggggatg
    14161 ccagtgaccg agttggcagt ggcgggtggt gcggaggtca ccgagcaggc cgacgaggag
    14221 ctgctggccg ccggttggac ccgcagcgcc gactggagca cggccgacga tggatggctg
    14281 gcaccggtcg tgccttcgta gcaacgaaag cgcgtagttc gcgcacggcg gcgcagtggc
    14341 gtctccgctc gcgacaagcg ggacgccact gcgtgcgcac cgttcaggac tgctgcggtg
    14401 actcgaaaag gggcgcgtat ccggtcggca gctgcgagcg caggtcgtgg atctcgcccg
    14461 ccgagacgaa ctcggcgatg ctgctcaaca ccgccctcgc atgggtcaag gcctgctcgg
    14521 tggtgcaacc gcgtccttcg cggtcggaca cgcgtcgcag gaaatcgtcg aggtcgtcgc
    14581 cgatctcggc ttgcccggtg ggccgcagca acggagcctg caactcggcc gggagctggc
    14641 tggccagatc ccggggttcg ttgcccgcca agcgctggcc cactgctgcc aggatctgct
    14701 tggtcgcggc gtcggcgtgc tcgcgctcgg tggggccacc tcgctgtccg actcgggtca
    14761 gaaattcgtc gtagttcatg tctgctcctt tccgaacggg ctcgcgggcc tcgtggtttt
    14821 tctgctcacc gccagacggg ttcgaagtcg cgggatgcga cgaactccgg tcgcggatgc
    14881 ttcgcggcga acggctcgtc cagcgtgttg tgcacgctgt tgaagacgat gaagatgttc
    14941 gatcgaggga acggcgtgat gttgttgccg gagccgtgca tcgagttcga gtcgaaccac
    15001 agcgccgacc cggccggacc ggtgaactgc tcgatgccgt gctcgtatgc cagccgggtg
    15061 atgtcgttct cgcccggtac tccggcccgc tgctcgacca gcgaggactt gtagttctcc
    15121 gccggggtct cgcccgcgca cgacacgaac gaccggtgcg cgccgggcat cagcatcaac
    15181 cccccgttga acggatagtt gtcggtcagc gcgatggaca ggctcaccgc ccggggagcg
    15241 ggcatgccgt cttcggcgtg ccaggtctcg aaatccgagt gccagtagaa gccgccaccg
    15301 cggaaacccg gcatgtagtt gatccggctc tggtgcacgt acacctcgga acccaggatc
    15361 tgccgcgcgc ggtcgagcac tcgcggatcg tgcacgagat cgacgatcgc cgggctcagg
    15421 tggtgcacgt cgaagatgga gcgaacttcg tcggtcccct tctccacgac cgtgcgctca
    15481 tccgcgcgaa cctgcgggtc ggcggtcaac cgttccagct cccgccaatg gtgctggacc
    15541 tcacccggcg acagcaggtc gaccgcgtga aacccggacc gctgatgggc gagcagctga
    15601 tcgctgtccg ccggaccggc agccggatcc gaccagacga ccgggtcccg gcgaggaaag
    15661 atcgcgcttc gggccgacga acgagtcggg tagcggtcag ccaccttggt gtggatgacg
    15721 gtcatccgga actcaactcc tcacatggct tgcacgtttg gcgtgcgctg taggggagga
    15781 gaagcttcga gccgcggtga gacgcatttc tccggcgtgc tgaggcccct cgctcctgca
    15841 gcggggtggc cccgtcagct ggccgtggcg ttcaaccggc ggggcagggc attcggcacc
    15901 cgaaggccct gacgtccggg aaagtgcccg ccgctgggcg acggtaaacc tgctgactac
    15961 cactcgattc gagctccggt aggttgtttg cgttccgcag cgtccggggt accggcccga
    16021 ttaggtcggt gctgtacccg gggaagcaac agaccgaggc ctgtccggtt cagccggaag
    16081 ctgcggcagg cccagggcca cgacgggggt gtgctcgttc cgacgtagcg cgcacatccc
    16141 cggtcctgcc gaacgcgtgg atgaggagga ttgagcgcgg tgaatgccga acaccccgcg
    16201 cggcgggtcg aagacgtcac cgatgctttc gatcagctct ctgcgctgct ggatcggttc
    16261 gagtcgctcg ataccgtgct caccaggctg accgactccg cgttggccac gatccccgac
    16321 accggtagtg ccagcgtcac cgtgctgcgc cacgaacacg cgcgaacggc cgcggccacg
    16381 catccgtggg cggcggaact cgacgagcac caatacagcg ccgaagacgg cccttgcctg
    16441 cacgcggccc gcaccgggcg actggttcgc ctggacaccg ccgagaccga ccggtggccg
    16501 gaattctccc gagcggcccg ggatcaggac gtcgcggtag cggtcggcgt tccgctgctc
    16561 atcgacgacg acatcgtgaa cacttcggcg gcgctgaacc tgaccacgcc gcagcaccag
    16621 gctttcgatc cgctcgacga agcgctgctg gaactgttca cgcacgcgct gtcgaccgcg
    16681 atcaaccacg cctaccgcca ccaacaagcc cgccggctcg ccgaccagct cggggacgcg
    16741 ctggacaacc gcgacgtgat cgggcaggcc aaaggtctgt tgatggcacg ccaccactgc
    16801 ggcccggagc aggcgttcga ctacctgcgg accgcttccc agcagtccaa cgtcaaactc
    16861 cgcgacgtcg ccgcccggct ggtggccgga gaaaccgcga accaccgcga ctgacagatg
    16921 tgccgcacgg ggtttgtcgg tcagcagcga tgggcagtag cttttgtgtg aacagcttac
    16981 tgactcaagg cggagactcg tccgggactg attccacgct gcgtgcggcg gccgtattct
    17041 tcggtcgttg gttggtgata gcagcggcgg cggctgtcgt gatctgggcc gccgcgcggt
    17101 tgttggtcgt cgtgttaccg ctggcactcg ccattttgct ggcctcactg ttgcggccgt
    17161 tcgtggctgc gctgagtcgg aggggaatgc cactcggcgc ggctacagcg atcgtcatgc
    17221 tcaccggcct cgtcgcagtg acagctgtgc tgctgttcgt ggtcgtgtcc gtgctgaaca
    17281 acgtagacgt gt
//
