LOCUS       NZ_JADDUE010000021     28654 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Saccharopolyspora sp. HNM0986
            NODE_21_length_38657_cov_72.557531_cov_72.557531, whole genome
            shotgun sequence.
ACCESSION   NZ_JADDUE010000021
VERSION     NZ_JADDUE010000021.1
KEYWORDS    WGS; RefSeq.
SOURCE      Saccharopolyspora sp. HNM0986
  ORGANISM  Saccharopolyspora sp. HNM0986
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (bases 1 to 38657)
  AUTHORS   Li,F.
  TITLE     Diversity and distribution of actinomycetes associated with coral in
            the coast of Hainan
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 38657)
  AUTHORS   Li,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2020) chool of Life and Pharmaceutical Sciences,
            Hainan University, 58 Renmin Avenue, Meilan District, Haikou, Hainan
            570208, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 232.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016526145.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 02:15:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,899
            CDSs (total)                      :: 5,838
            Genes (coding)                    :: 5,784
            CDSs (with protein)               :: 5,784
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 7 of 54
            Pseudo Genes (incomplete)         :: 49 of 54
            Pseudo Genes (internal stop)      :: 0 of 54
            Pseudo Genes (multiple problems)  :: 2 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:09:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5881
            Orig. end                         :: 34535
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADDUE010000021.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..28654
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..28654
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28654
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:18654]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18654
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     misc_feature    complement(732..748)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.49"
                     /tool="antismash"
     gene            complement(805..1698)
                     /locus_tag="INP57_RS28620"
                     /old_locus_tag="INP57_28635"
     CDS             complement(805..1698)
                     /NRPS_PKS="Domain: PKS_ER (1-294). E-value: 1.2e-34. Score:
                     111.8. Matches aSDomain:
                     nrpspksdomains_INP57_RS28620_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010224517.1"
                     /locus_tag="INP57_RS28620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28635"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_307850332.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.7e-28, bitscore:
                     90.6, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVRLRAGALNWHDVLVRQGKYGSKLPHVPGADGAGTRLDTGEEV
                     VVLPSLWWGDDESAPAPGWEILGDHHAGTYAELVTVPVDCVRPKPQGLNWREAAALPLV
                     GLTTHRALFARGRLCKDESLLVLGAGGGVATMAVQLAAATGAKVVVTSSSRDKVDNARE
                     LGAEGGVRYTDDDWWEQAKQLSPGGLGFDVVLDPVGSWQEAVHALRPGGRLVVLGASRR
                     SDAVLDVRHFYFGQYDLLGTTMGSPRDFDGLLSLVDGGVVGAPVVDRAFPLDQAAEAHE
                     YLERGGGFGKIVLDCE"
     aSDomain        complement(817..1695)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_INP57_RS28620_PKS_ER.1"
                     /evalue="1.20E-34"
                     /label="INP57_RS28620_PKS_ER.1"
                     /locus_tag="INP57_RS28620"
                     /protein_end="294"
                     /protein_start="1"
                     /score="111.8"
                     /tool="antismash"
                     /translation="TVRLRAGALNWHDVLVRQGKYGSKLPHVPGADGAGTRLDTGEEVV
                     VLPSLWWGDDESAPAPGWEILGDHHAGTYAELVTVPVDCVRPKPQGLNWREAAALPLVG
                     LTTHRALFARGRLCKDESLLVLGAGGGVATMAVQLAAATGAKVVVTSSSRDKVDNAREL
                     GAEGGVRYTDDDWWEQAKQLSPGGLGFDVVLDPVGSWQEAVHALRPGGRLVVLGASRRS
                     DAVLDVRHFYFGQYDLLGTTMGSPRDFDGLLSLVDGGVVGAPVVDRAFPLDQAAEAHEY
                     LERGGGFGKIVL"
     CDS_motif       complement(1276..1338)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_INP57_RS28620_0001"
                     /evalue="3.20E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="INP57_RS28620"
                     /protein_end="141"
                     /protein_start="120"
                     /score="10.3"
                     /tool="antismash"
                     /translation="DESLLVLGAGGGVATMAVQLA"
     gene            2089..3264
                     /locus_tag="INP57_RS30460"
                     /old_locus_tag="INP57_28640"
     CDS             2089..3264
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024583.5"
                     /locus_tag="INP57_RS30460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28640"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_200073489.1"
                     /transl_table=11
                     /translation="MNGAVQRYDRGSAQERRISAALEEPLRQAREVLSAAGDLTRAPGL
                     IPDGGLDMHNAVHAINAADRIVTKRIAAQPDDAAQRQQLIDLLVQVSAMRDAISEAHLA
                     NRATAMTDVNDALRQMHSAASVQQLVQIVPKIVGQLGYDRTLLSHIEGDRWIAQSAHAD
                     ADAVLAESMVEVGTAAPGVLDRNVPEGHVFRRRVPVLVKDAQARPEVHRELKTLMQTRS
                     YVSAPVVVNNRVVGLVHADDSASPGGVDELARQVLGLFAEGLGFVFERTSCYERLNALQ
                     HRLRVETRAVADAVDVFAESDSGAPLVARQGSLDMAGSAGKSDSTPPLPELTRRELEVL
                     ARLATGERNAEIATRLFVSEGTVKTHVKSILRKLGAENRAQAVARYHAMSH"
     misc_feature    complement(3385..3401)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.79"
                     /tool="antismash"
     gene            3522..4847
                     /locus_tag="INP57_RS28630"
                     /old_locus_tag="INP57_28645"
     CDS             3522..4847
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010224518.1"
                     /locus_tag="INP57_RS28630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28645"
                     /product="cytochrome P450"
                     /protein_id="WP_200073490.1"
                     /sec_met_domain="p450 (E-value: 1.5e-34, bitscore: 110.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTEETNLTPIPDEIANQVVLPEGHRDETRLFEAYRWLRENNPL
                     AKVTVEGFDPVYLVTKHADIMEIERQPDIFTSGGGEEPGSHNPILTNQAGDEFTKSINN
                     GSLRVLETVTFLDPPEHTLVRDIAAEWFRPATLKKWEDTIRTLAQEAIAKGLRSGTNEI
                     DFVKDFALYFPLHVIMSLFGVPVEDEPRMMGLTQDFFGAADPDAARQDVAPTTPEAAAQ
                     QFAAAIQDFYAYFDRLVEDRRATPEDDLATIIANARQEDGEFFAKEVAYGWFIAIATAG
                     HDTTSSTLSSAIEALAHHPDQLRRVQEDPKLIPHLVNESLRWSSPVKQFTRQATQEYEL
                     RGRQIKPGDRFALLYQSANQDTDIFNDPETFNIDRRPNKHIAFGYGPHMCVGQHLAKQE
                     LRIMFEELLPRIERVEVTGERKLVQTNFVGGLKNLPVNLVLR"
     misc_feature    3564..3575
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 16.87"
                     /tool="antismash"
     gene            4844..6082
                     /locus_tag="INP57_RS28635"
                     /old_locus_tag="INP57_28650"
     CDS             4844..6082
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010224519.1"
                     /locus_tag="INP57_RS28635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28650"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_233628650.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 4.2e-64, bitscore:
                     207.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQGTGSTSDDRRVVIVGGGHAGGTLTGLLRQGGFTGEVVLIGEE
                     PDPPYHRPPLSKSFDDDGLEQWLRDFAFYGEQDIDLRLGEEVVSLDRDARRVVTSSGRS
                     VDYDVLVLATGAAPRAIPVPGGDLEGVLELRTLADARQLRAAVQRDGGIVVVGGGYVGL
                     EVAAAARARGDEATVVERESRILARVASTSLSEILTEYHQRNGTDVRTGAQVIELAEKH
                     GSVRGVVLSDGTEIPCGSVLVGVGAVPRDRLAEEAGLVCAGGILVDSMTRTSDPAVLAI
                     GDVTRRPLPGRPDPVRMESIPSAVEQAKQAASIILNTRQPRPEVPWFWSDQFDLKLKIA
                     GLPGSADVLCRGDPTAGKFALFHHEGGVVSCVESANAAAEFMAARKLIANGARIDPAKL
                     ADPEVPLRSAVSQ"
     gene            6096..6416
                     /locus_tag="INP57_RS28640"
                     /old_locus_tag="INP57_28655"
     CDS             6096..6416
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010224520.1"
                     /locus_tag="INP57_RS28640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28655"
                     /product="2Fe-2S iron-sulfur cluster-binding protein"
                     /protein_id="WP_200073491.1"
                     /transl_table=11
                     /translation="MPKVVYVLPDGSTNEVDVPVGQSVMDGSVRNNLPGIVAECGGSCS
                     CATCHVHLDEQWWDFFDEPSDEENELLEFAEGAQSNSRLSCQLIVSDACDGVQVTALDN
                     DG"
     gene            6447..7550
                     /locus_tag="INP57_RS28645"
                     /old_locus_tag="INP57_28660"
     CDS             6447..7550
                     /NRPS_PKS="Domain: PKS_ER (18-279). E-value: 3e-12. Score:
                     38.2. Matches aSDomain:
                     nrpspksdomains_INP57_RS28645_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF028222.5"
                     /locus_tag="INP57_RS28645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28660"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_200073492.1"
                     /sec_met_domain="ADH_N (E-value: 4.1e-25, bitscore: 79.2,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2e-18, bitscore:
                     58.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQITAAVVDQAGGDFTPQEVSLGEPAGDEVLVEVVGAGLCHTDIA
                     VKEGHLPFPFPGVLGHEASGVVVEVGSSVTKVGKGDKVAVSFNSCGACVQCKKDAPAYC
                     EQFMAANFGGQRFDGSSALSRGQEQIGSNFFGQSSLATHAIAHERNVVKVPDSAPLELV
                     GPLGCGVQTGAGAVMNSLDCEPGSSVLVLGGGSVGLSAVLGAAARGLRTIIVAEPMGQR
                     RELARELGATHVIDPAEGTLSEMVRAVAPEGVEYAVDTTAQVPVIEQAVLSLGQRGAIG
                     LLGVPADPAAALPLSLIQTQVTGTRVVGIVEGDSDPDTFIPLLLELHAAGRFPFDKLIT
                     KKPFSAINEAVAAQHEGEAIKIVLVHD"
     aSDomain        6501..7283
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_INP57_RS28645_PKS_ER.1"
                     /evalue="3.00E-12"
                     /label="INP57_RS28645_PKS_ER.1"
                     /locus_tag="INP57_RS28645"
                     /protein_end="279"
                     /protein_start="18"
                     /score="38.2"
                     /tool="antismash"
                     /translation="EVSLGEPAGDEVLVEVVGAGLCHTDIAVKEGHLPFPFPGVLGHEA
                     SGVVVEVGSSVTKVGKGDKVAVSFNSCGACVQCKKDAPAYCEQFMAANFGGQRFDGSSA
                     LSRGQEQIGSNFFGQSSLATHAIAHERNVVKVPDSAPLELVGPLGCGVQTGAGAVMNSL
                     DCEPGSSVLVLGGGSVGLSAVLGAAARGLRTIIVAEPMGQRRELARELGATHVIDPAEG
                     TLSEMVRAVAPEGVEYAVDTTAQVPVIEQAVLSLGQRGA"
     CDS_motif       6621..6659
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_INP57_RS28645_0001"
                     /evalue="7.80E-04"
                     /label="PKSI-ER_m2"
                     /locus_tag="INP57_RS28645"
                     /protein_end="71"
                     /protein_start="58"
                     /score="12.4"
                     /tool="antismash"
                     /translation="LGHEASGVVVEVG"
     gene            complement(8054..9508)
                     /locus_tag="INP57_RS28650"
                     /old_locus_tag="INP57_28665"
     CDS             complement(8054..9508)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010224521.1"
                     /locus_tag="INP57_RS28650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28665"
                     /product="aldehyde dehydrogenase"
                     /protein_id="WP_200073493.1"
                     /sec_met_domain="Aldedh (E-value: 1e-158, bitscore: 519.9,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKLVYDKLYIGGEWVAPQSTDTIEPVSASTEELLGKVPHAGEAD
                     VDRAVTSARAAFDDPSGWAHWPASRRAEVMRRFAASLESRAEEMVRRISGQNGMPVAIG
                     QQLEAVFPAMLLRYYADLAEGTEVEERRPGLLGGTTLVRREPIGVVGAIVPWNFPQSLA
                     FFKIAPAMAAGCTVVMKPSPETVLDSYLMAEAAEEAGVPPGVLSIVPGGREIGAYIVEH
                     PKVDKIGFTGSTVAGRAIAQRCGELLRPVTLELGGKSAAIVLEDADLASNVENLFSACL
                     MNNGQTCYAGTRILAPRKRYDEVVDIFTQLASSLSVGDALDPATQIGPMATAKQRERVE
                     GYIAKGKHEGARITTGGGRPNDLGKGWFVEPTILADVDNRTTVAQEEIFGPVLSVIPYD
                     DVDGAVQLANEVDYGLGGSVFTGDPAKGLDVARRVQTGTIGINAYLPDPTAPFGGIKGS
                     GMGRELGPEGLAAYHRIQSVYLDSSQ"
     misc_feature    9492..9507
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.9"
                     /tool="antismash"
     gene            10001..11671
                     /locus_tag="INP57_RS28655"
                     /old_locus_tag="INP57_28670"
     CDS             10001..11671
                     /NRPS_PKS="Domain: AMP-binding (34-450). E-value: 3.7e-86.
                     Score: 281.2. Matches aSDomain:
                     nrpspksdomains_INP57_RS28655_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="INP57_RS28655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28670"
                     /product="AMP-binding protein"
                     /protein_id="WP_200073494.1"
                     /sec_met_domain="AMP-binding (E-value: 3.5e-95, bitscore:
                     310.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPTATVQDRYTDEDAKRFYRAGFWQDANLFDLVEAQAQVRPDKI
                     FASDGTTNLTFRDLRDRGARLALGLRRLGIRPGDRVAVQLPNWSEFTLIATALGRIGGI
                     LVPIMPIFREDEVEYLLTHSGAKAAITCEQFKNFGYVEMYSRLRSRCPELQEIISVRST
                     GTDGRCIPLEELVVSDQVAGEDPELGPHPSPDDGFLIVYTSGTTSRPKGCFHTLNTVRA
                     SSAAIARSLDYRESDVQFGPSPITHSTGLVTSMLLPLQSGAASHLMDAWEPNAAMRRIA
                     EYGCTSAVTATAFLEMLLNVYNPDQHDPSSMRMWVCAGAPVPASVVHRAEEMLGGCRIL
                     SLYGRSENFLTTMCTVDDAPERSATSDGAAVKSAGASVQVVDDRGEEVPRGTEGDIAYK
                     GPSHMIEYFRDPEQTAALFTPDGYSRSGDLGYMDQDGYVRVTGRSKDIVIRGGLNISAR
                     ELEELLAEHPLVANVAVVAMPDARLGEKVCVYVVPAEPADRPSLESIVSYLRGRRVATP
                     KLPERLELVEELPLTATGKVQKHVLRDDIKQKLQDGGVV"
     aSDomain        10103..11350
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_INP57_RS28655_AMP-binding.1"
                     /evalue="3.70E-86"
                     /label="INP57_RS28655_AMP-binding.1"
                     /locus_tag="INP57_RS28655"
                     /protein_end="450"
                     /protein_start="34"
                     /score="281.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="EAQAQVRPDKIFASDGTTNLTFRDLRDRGARLALGLRRLGIRPGD
                     RVAVQLPNWSEFTLIATALGRIGGILVPIMPIFREDEVEYLLTHSGAKAAITCEQFKNF
                     GYVEMYSRLRSRCPELQEIISVRSTGTDGRCIPLEELVVSDQVAGEDPELGPHPSPDDG
                     FLIVYTSGTTSRPKGCFHTLNTVRASSAAIARSLDYRESDVQFGPSPITHSTGLVTSML
                     LPLQSGAASHLMDAWEPNAAMRRIAEYGCTSAVTATAFLEMLLNVYNPDQHDPSSMRMW
                     VCAGAPVPASVVHRAEEMLGGCRILSLYGRSENFLTTMCTVDDAPERSATSDGAAVKSA
                     GASVQVVDDRGEEVPRGTEGDIAYKGPSHMIEYFRDPEQTAALFTPDGYSRSGDLGYMD
                     QDGYVRVTGRSKDIVIR"
     CDS_motif       10598..10642
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_INP57_RS28655_0001"
                     /evalue="5.70E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="INP57_RS28655"
                     /protein_end="214"
                     /protein_start="199"
                     /score="16.0"
                     /tool="antismash"
                     /translation="IVYTSGTTSRPKGCF"
     gene            complement(12029..12982)
                     /locus_tag="INP57_RS28660"
                     /old_locus_tag="INP57_28675"
     CDS             complement(12029..12982)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019816106.1"
                     /locus_tag="INP57_RS28660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28675"
                     /product="electron transfer flavoprotein subunit alpha/FixB
                     family protein"
                     /protein_id="WP_200073495.1"
                     /transl_table=11
                     /translation="MSEVLVLVDHVDGEVKKVTAELLTAARWLGEPSAVVVGEPGVAAK
                     VADALTAHGTAKIYAAESPEAARLLLVPEVDVLAELVATREPSAVLVPASVDGKEIAGR
                     LAVRLGSGLLSEVVDLGPEGVASHSLFGGAYLAEAEVTAGVSVLSVLPGSIEPVDEPSS
                     PITEEVAIGVAGKAARITGRQPAEAGERPDLAEAPVVVSGGRGVGSAESFEVVEQLADS
                     LGAAVGASRAAVDSGYYPAQFQVGQTGKTVSPNLYVALGISGAIQHRAGMQTSKTIVAV
                     NKDPEAPIFEIADFGIVGDLFQVAPQLTGAVAELKS"
     gene            complement(13013..13798)
                     /locus_tag="INP57_RS28665"
                     /old_locus_tag="INP57_28680"
     CDS             complement(13013..13798)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155452.1"
                     /locus_tag="INP57_RS28665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28680"
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="WP_200073518.1"
                     /transl_table=11
                     /translation="MLNVVVLVKQVPDTYSERRLTETDHALDRESVDAVLDEINERAVE
                     AALQIVESHGGEVTAVCMGPDRATDAIRKALSMGAHKAVHLSDEALRGTDAPATARALA
                     KVIGTLEAVDLIIAGNEATDGRSGAVPAMLAELLGWPQLTHARSVELDGSTVRAARETD
                     AGVLQLEAELPAVLSVTEKINEPRYPSFKGIMAAKKKPLSVLALADAGIDAAEVGTAHA
                     GSRVLAAAPRPPKPAGQKLDDAGDGGTRIAEYLAAQKLV"
     gene            14086..14781
                     /locus_tag="INP57_RS28670"
                     /old_locus_tag="INP57_28685"
     CDS             14086..14781
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013757.5"
                     /locus_tag="INP57_RS28670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28685"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_200073496.1"
                     /transl_table=11
                     /translation="MTRVAAILEAAAAAPDGLRLGTLRELLNAPKSSVHGLVKGLVAVG
                     YLAEQDGRYTLGPAMATVAAAARPTVVDMARAPMEKLHRQFDETVMLGSMTGETLVYLD
                     TIESTQAIRYSPPKVRRHFENPSAMMKLHLAERTPEQLDDYLLARISVPQRRKELSAEL
                     AAVRERGVAFNRGDTFPDLSAAAIGLTERGKLVACIAVGGPSPRVNPLLDEIAAALSEA
                     AAEISQHLT"
     misc_feature    complement(14928..14944)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.09"
                     /tool="antismash"
     misc_feature    15144..15160
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.48"
                     /tool="antismash"
     gene            15198..16418
                     /locus_tag="INP57_RS28675"
                     /old_locus_tag="INP57_28690"
     CDS             15198..16418
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013676190.1"
                     /locus_tag="INP57_RS28675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28690"
                     /product="CaiB/BaiF CoA-transferase family protein"
                     /protein_id="WP_200073497.1"
                     /transl_table=11
                     /translation="MADRRDAHSASPDPGPLHGVTVVALEHAVAVPIATRQLADLGARV
                     IKVERRDGGDFARHYDDVVRGGLSSVFLWTGRGKESITTDLKQPEGREVLHALLAEADV
                     FIQNLSPGAVDRMGFGDEDLRTLHPRLIVVSNSGYGEPGPYSGRRAYDALVQCESGVVA
                     ATGTGDEMVKPGFSAADVASGMHMYSAVLMALYQRERTGQGTIVEVAMLDAITDWIANH
                     LYYTQHNGAPPERVNIGHPSLVPYGAFATADGDQVVIGVQNDREWARFARTVLQSPALV
                     DDPSTATTIARAEHRARVDALVNDATSRLGTAKLLQLLDEAQIANARVNSLAEAADHPQ
                     FTARDRWVEVESPVGPVDTLRQVIQERGKQYPAGPVPELGAHTDALLGELGYSAAAIAD
                     LRRREVV"
     gene            16469..17623
                     /locus_tag="INP57_RS28680"
                     /old_locus_tag="INP57_28695"
     CDS             16469..17623
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010224546.1"
                     /locus_tag="INP57_RS28680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28695"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_200073498.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.8e-22, bitscore:
                     71.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.9e-19, bitscore:
                     61.1, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.1e-45, bitscore:
                     145.4, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSFAFTEEQQDFQRTLADFTRRNLLPGYRDRAASTTFPFDVLRR
                     LGELGVLGIGLPEKFGGTGQEDPIMLGLATETLAYGDVNLASAPVQTGLIASQLLHADE
                     AVQERYLPPMIEGRETVAIALTEPGSGSDAAAMSTVARPVSGGWRLSGEKTAISWACNA
                     SAALIYARDPGSTRSSGVSCYLVPLDSAGAAVHHMPGMGCLPLGWGSIHLDDVFVPASH
                     LVGEPGTGFQAVMSHFDFSRAALGLMCLGAAQVSLDEAAAYATQRHAFGKPIAENQGVS
                     FPLAEHATYLEAARWMCYHALWMREQEQPHTSLASMSKWWPPVAAKDAVEAAMKIHGNL
                     GYSTEFPLQQRYRDVMAYLVADGTAEIQKRIIAKDVLERGSVVF"
     gene            complement(17620..18654)
                     /gene="dmpG"
                     /locus_tag="INP57_RS28685"
                     /old_locus_tag="INP57_28700"
     CDS             complement(17620..18654)
                     /EC_number="4.1.3.39"
                     /GO_function="GO:0008701 - 4-hydroxy-2-oxovalerate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009056 - catabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dmpG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003448357.1"
                     /locus_tag="INP57_RS28685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28700"
                     /product="4-hydroxy-2-oxovalerate aldolase"
                     /protein_id="WP_307850333.1"
                     /sec_met_domain="HMGL-like (E-value: 2.3e-63, bitscore:
                     205.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPHQSTPRLYIQDVTLRDGMHAIRHRLAPDRVRAIAAALDSAG
                     VDAIEVAHGDGLAGGSVTYGPGSNTDWEWISAAAEVVNRAVLTTLLLPGIGTIKELERA
                     HELGVRSVRVATHATEADIAAQHIGKARDLGMDVSGFLMMSHMASPTELAKQAVQLESA
                     GARCVYVTDSGGRLTMRDVRERIRAYRDVLDDATEIGIHAHENLSLSVANSVVAVEEGV
                     TRVDASLAGHGAGAGNCPLEAFVAVADLHGWQHGCDLFALQDAADDIVRPLQDRAVRVD
                     RETLTLGYAGVYSSFLRHAERAAAEHGLDTRQILVEVGRRGLVGGQEDMIADIALELTA
                     DSPR"
     gene            complement(18651..19598)
                     /locus_tag="INP57_RS28690"
                     /old_locus_tag="INP57_28705"
     CDS             complement(18651..19598)
                     /EC_number="1.2.1.10"
                     /GO_function="GO:0008774 - acetaldehyde dehydrogenase
                     (acetylating) activity [Evidence IEA]"
                     /GO_process="GO:0009056 - catabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017988063.1"
                     /locus_tag="INP57_RS28690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28705"
                     /product="acetaldehyde dehydrogenase (acetylating)"
                     /protein_id="WP_200073499.1"
                     /transl_table=11
                     /translation="MKTKVAIIGSGNIGTDLLIKVIRLSDSLDMGVMVGVDPTSDGLAR
                     ARRLGVSTTDRGVEGLLGMPEFADVDVVFDATSATAHERNSALLEPHGKLLVDLTPAAI
                     GPFVVPAVNLDAHRTATNVNMVTCGGQATIPVVAAVSRVAPVRYAEIVASIASKSAGPG
                     TRANIDEFTETTAKAIEVVGGADRGKAIIVLNPAEPPMIMRDTVLCLAGDGDPELIRDS
                     VERMVAEVSRYVPGYRLKQQVQITPVAADEPLGTLIDAAPRPSWKVSVFLAVEGAAHYL
                     PAYAGNLDIMTSAALRTAEQLAANAARQRVEVDT"
     gene            complement(19595..20404)
                     /locus_tag="INP57_RS28695"
                     /old_locus_tag="INP57_28710"
     CDS             complement(19595..20404)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005464750.1"
                     /locus_tag="INP57_RS28695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28710"
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="WP_307850334.1"
                     /transl_table=11
                     /translation="MPELTGIEAAAERLLDAAKTRVPCAPVRDLLPDAAATTAYAVQSM
                     LTRHRSDRGGRIVGRKIGLTSPAVQQQLGVDQPDFGVLFDDMAVPAGTAVDTAQLLQPR
                     IEAEIALVLGSDLDGPHIDLASVREAVAGMVPALEIVDSRIAGWDISFPDTVADNASSG
                     MFVLGGTQLDFAGADLREVEMTMVDGQGRTVSSGSGAACLGDPLNALLWLARTCYELGM
                     PLRSGEIVLSGALGPMVPVSAGMSFSATLSGLGTVTAEFSGNAGGAT"
     gene            complement(20435..21406)
                     /locus_tag="INP57_RS28700"
                     /old_locus_tag="INP57_28715"
     CDS             complement(20435..21406)
                     /NRPS_PKS="Domain: Abhydrolase_1 (38-283). E-value: 8e-27.
                     Score: 86.3. Matches aSDomain:
                     nrpspksdomains_INP57_RS28700_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987141.1"
                     /locus_tag="INP57_RS28700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28715"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_200073500.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.3e-19, bitscore:
                     61.0, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 2.1e-24, bitscore: 77.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALTSENLVETPGMASRWVRLASGARAHYMTSGDTGPAVVLLHGG
                     LPGSSGLAGWRFMASYLGERGFRVYCPDMPAFGLSDPRPEHWPRGMEDFVDFIYDFADA
                     LCLDRFHLAGNSMGCMNTVNYTVAHPERVLSFALIAGDVGDVVPEEIKPPQGQFHMTAY
                     DGTREGMRSMMEAIIHRPEAVSDDLVEMRYLSAAERLEAHQQFWPTLLQYRHIVPWTDQ
                     NRAARLATKGRLDRLEIPGIYLYGRQDILTPVEWGHVQEDHLPNVQFFYPDDCGHQGQT
                     DRPDLFNPVFHEFFAHGTVPGELADEAGVSDRRPELPLIKRG"
     aSDomain        complement(20558..21292)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_INP57_RS28700_Abhydrolase_1.1"
                     /evalue="8.00E-27"
                     /label="INP57_RS28700_Abhydrolase_1.1"
                     /locus_tag="INP57_RS28700"
                     /protein_end="283"
                     /protein_start="38"
                     /score="86.3"
                     /tool="antismash"
                     /translation="VVLLHGGLPGSSGLAGWRFMASYLGERGFRVYCPDMPAFGLSDPR
                     PEHWPRGMEDFVDFIYDFADALCLDRFHLAGNSMGCMNTVNYTVAHPERVLSFALIAGD
                     VGDVVPEEIKPPQGQFHMTAYDGTREGMRSMMEAIIHRPEAVSDDLVEMRYLSAAERLE
                     AHQQFWPTLLQYRHIVPWTDQNRAARLATKGRLDRLEIPGIYLYGRQDILTPVEWGHVQ
                     EDHLPNVQFFYPDDCGHQGQTDR"
     gene            complement(21406..22434)
                     /locus_tag="INP57_RS28705"
                     /old_locus_tag="INP57_28720"
     CDS             complement(21406..22434)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016777.5"
                     /locus_tag="INP57_RS28705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28720"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_200073501.1"
                     /transl_table=11
                     /translation="MPELTAVDVHAHHFGPDAGETPVRHDTDAPRLVIDGDGSGQIMRG
                     DTTFRAVEPVLWDVNLRLAEMDRAGLSHQVVSPVPVVMEHASGADPECARSTNDSIAEA
                     CEQSGGRLLGLGCLPLGDIDAAIAELRRCREIGLHGVEVGTRIGELDLDAPDLDRFWDA
                     CDATASAVFVHPVQGGRDVVRRAGAPYDLGLGMLTDTAIAASALVFGGVLAEREQLRVV
                     LAHGCGTFPWAYPRLRLAANLTGDIADRDRLARRLFVDTLVFDDEHLGLLVHRFGADRL
                     VLGSDAPFFPDQMAKSMNSVRAAQQTGVLPEHVDPPFLARNAAELLGLATDPPRTSCEG
                     AR"
     misc_feature    complement(22411..22425)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    complement(22459..22479)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.72"
                     /tool="antismash"
     gene            22666..23460
                     /locus_tag="INP57_RS28710"
                     /old_locus_tag="INP57_28725"
     CDS             22666..23460
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013757.5"
                     /locus_tag="INP57_RS28710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28725"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_233628674.1"
                     /transl_table=11
                     /translation="MHEQKQESPPTSILSKAFDVLGAFGPDHRVLTLTEIACASGLPKS
                     TVHRLLGRLTELGVIEPHCAGFKVGLPLRRFASAMPIESLRQSALPHLGALHHWSRRHV
                     HMATLRGERVVFVERMMVPGHELPSADPGTDLPAHATALGKALLAFAPPDEVDSALAGP
                     LHAVAPNTITDAAEFRAELAEVQRNRFAGARGESHPDVCCLAAPVLIRGRAVGALSVSS
                     TAGERNSDRALIDAVRVTADRIATDNAKVLADGHEDWFPGRL"
     misc_feature    complement(22698..22711)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.45"
                     /tool="antismash"
     misc_feature    22876..22878
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(23580..24641)
                     /locus_tag="INP57_RS28715"
                     /old_locus_tag="INP57_28730"
     CDS             complement(23580..24641)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498672.1"
                     /locus_tag="INP57_RS28715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28730"
                     /product="extradiol ring-cleavage dioxygenase"
                     /protein_id="WP_200073503.1"
                     /transl_table=11
                     /translation="MSRFLGLGMTHYPLLAGTDEHMAGLLRWTLQDPDIPEREKDPASW
                     PASMRAEWGADQGRSAAAGHRAHLLDGLARCRAALDEFAPDVVVVWGDDQYENFREEVV
                     PPFCVLAYDDLEVPAFEVMNERGSPNAWGLPDDFRITLRGDSAIARRLADGLINDGVDM
                     AYSYRKRDGAHFPHAILNTQLFLDYDHAGARFAYRLLPITVNCYGEHAIARKGGLARFA
                     DISSEELDPSGPSPARCVEVGRAIARHFAGNDERVAFIASSSWSHAFLTDALWHIRPDT
                     AADRRLYQLMVEGRFDDLAVVSGRDVVAAGQHEMLNWFCLFGAVQELGLQRRWSTMVTT
                     DVFNSNKPFGIFS"
     gene            complement(24638..24898)
                     /locus_tag="INP57_RS28720"
                     /old_locus_tag="INP57_28735"
     CDS             complement(24638..24898)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS28720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_28735"
                     /product="hypothetical protein"
                     /protein_id="WP_200073504.1"
                     /transl_table=11
                     /translation="MRIVDHHEPDGPDKILHIRSVGCDINIIVGTHDPNGIPFTTVEVL
                     PHEPDEDGTNWWHLGTSSVVVMPESHVAPTPRGTQNGAERR"
     misc_feature    24993..25007
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.69"
                     /tool="antismash"
     gene            25123..26433
                     /locus_tag="INP57_RS28725"
                     /old_locus_tag="INP57_28740"
     CDS             25123..26433
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013044.5"
                     /locus_tag="INP57_RS28725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28740"
                     /product="aromatic ring-hydroxylating dioxygenase subunit
                     alpha"
                     /protein_id="WP_200073505.1"
                     /transl_table=11
                     /translation="MPDPLVIDNRKDSLFQVDREVFTSQEVFERERELLFGPSWLYVGH
                     ESEIPERNDFRTRDVGGRSIIFNRDRRGEVRVLLNTCLHRGASVCRHPAGKAKIFTCFY
                     HGWAYRNSGELVNVPSAEDYAASPADVYGGLHTPRIESYRGFWFVNFSGDAPDLRSWLG
                     TATYLLDLAVDQSEDGIEVLTGTHNYELHANWKLLVENSVDGYHAKSVHHTYFEMMMEL
                     GQTPPMLGDADTNGVPPAGLGTEFDNGHATLIYPGNGLPLANENVVRNLAELREKAVQR
                     CGESYATAVFDLARNSIFFPNFVLIDLNFGMILRTIMPVAPDRTEVTSWHIAPRGLDGE
                     SLQYRIDNALTFWGPAGLATPDDVEALEQAQRGFSARKELRWSDISKGMGKTRPAANDE
                     LQMRAWWRQWNALMTGERLPREVDEFVPFDTRAPQGA"
     misc_feature    25155..25169
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.96"
                     /tool="antismash"
     gene            26435..26938
                     /locus_tag="INP57_RS28730"
                     /old_locus_tag="INP57_28745"
     CDS             26435..26938
                     /EC_number="1.14.-.-"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024966.5"
                     /locus_tag="INP57_RS28730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28745"
                     /product="aromatic-ring-hydroxylating dioxygenase subunit
                     beta"
                     /protein_id="WP_200073506.1"
                     /transl_table=11
                     /translation="MTAATPNAATVTRSEVEDFLFLESSLLDEWRLEEWVELFTLDCTY
                     EAPATDAPASDPGQTWSLIHDRRTMLEQRVIRLKKPEAHAEFPHSQTSRIVGNVRILDR
                     GPDAVSVSASFLVSRMKAGKFDQYAGHYYYDLVQGEDGFKIRRKKAVLAHDRLAPQGKI
                     SFVL"
     gene            26974..27327
                     /locus_tag="INP57_RS28735"
                     /old_locus_tag="INP57_28750"
     CDS             26974..27327
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025178.5"
                     /locus_tag="INP57_RS28735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28750"
                     /product="non-heme iron oxygenase ferredoxin subunit"
                     /protein_id="WP_200073507.1"
                     /transl_table=11
                     /translation="MSEPSAVSDRVLACETDELADGESMTVEPDNGEAIAVYRVDGQFY
                     ATADMCTHEEWSLGEEGELCGFEVTCTLHNAKFDIRDGTALCFPATVALRRYPTTVEAG
                     KVYVLTEESAGED"
     gene            27317..28105
                     /locus_tag="INP57_RS28740"
                     /old_locus_tag="INP57_28755"
     CDS             27317..28105
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498676.1"
                     /locus_tag="INP57_RS28740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28755"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_200073508.1"
                     /transl_table=11
                     /translation="MRTERFTGRVAVVTGGASPIGFGIAARLADEGATLVLGDVDTDRL
                     RTAAAELASDPPGRVRTVSGDLSERADAERLIATAAETAGRLDILVNCAGGGVILPTPE
                     HTEDTVRATIDRNLWTTLHCTLAVLPIMSGAGYGRIVNIGAESVRNGLYRHAVYNAAKG
                     GVHAFATGLAREYAERGITVNTVAPAWISTPEADARIVAAPEAERRDMAEFFAQIRSTI
                     PMGRPGTVAEVAAAVAFVAAEEASYVTGQTISVNGGSSML"
ORIGIN
        1 ttgccctctt cgccgacgcg gtcctcgacc gggatgcgga gttcgtcgat gaacagctcg
       61 ttggagctga ccgcgttgcg tcccatcttg tcgatcggcc ggatgtccac gcggtcacgg
      121 tcgaggtcgg tgaagaacag cgtgaggccg tcggtcttct tctccgcgtc ctcgaacttg
      181 gtcgtgcgcg tcagcagcag gaccttctcg gactcgcggg ccttggagat ccacaccttg
      241 cggccgttga ccacgtagtg gtcgccgtcg cggcgcgcga acgtggtgat cttggtggtg
      301 tccagtcctg cctccggctc ggtgacgccg aagcacgcat gcagctcccc gttgacgatg
      361 cgcgggaggt tgcggcgctt caggtcctcc gaaccgtgca cgatcaccgg atgcagcccg
      421 aagatggaca gatgcatcga gctggccgcg ttcatcccgc cgccggacgc ggagacctct
      481 tccagcaaca gcgacgcctc ggtgatcccg tatccgtgcc cgccgtactc ctcgggcgtg
      541 gtgatgccca gccacccgcc gcgggcgaac gcgtcgtaga actcggtcgg gaactcgtgc
      601 gccgcgtcct tctccagcca gtactggtcg ctgaacttgc cggccagctc ggcgaccgcg
      661 ttgcggatcg tcgcttgatc ctcggtcaac tcaaagtcca cagcagatct cccactcgcc
      721 ccgttgaggg tttggagcaa tcttactaaa ggactgacca aaataaaacc ggatgccaca
      781 cttccgacgt ccgcctcggc gaggtcactc gcagtcgagg acgatcttgc cgaacccgcc
      841 gccgcgctcc aggtattcat gcgcctcagc ggcctggtcg agcggaaacg cccgatcgac
      901 caccggcgcc cctaccacac caccatccac aagggacaga agtccgtcga agtcccgcgg
      961 gcttcccatg gtcgtgccga gcaggtcgta ctggccgaag tagaagtgcc gcacgtcgag
     1021 caccgcgtcc gagcgccgcg atgcgcccaa caccacgagc cgtccacccg gccgtagggc
     1081 gtgcacggcc tcctgccaac tgcccacggg atccagcacc acgtcaaaac cgagcccacc
     1141 tggcgacagc tgcttggcct gctcccacca gtcgtcgtcg gtgtagcgca cgccgccttc
     1201 tgcgccgagc tcgcgcgcat tgtcgacctt gtcccgcgag gaggacgtga ccacgacctt
     1261 cgcaccggtc gccgctgcga gttgcacggc catcgtcgcg acaccgccac cggcaccgag
     1321 gaccaggagg gattcgtcct tgcagaggcg gccacgggcg aacagcgcgc gatgggtcgt
     1381 gagccccacc aacggcagcg ctgccgcctc gcgccagttc aacccctgcg gtttgggacg
     1441 cacgcaatca acaggcacgg tgaccagctc cgcgtaggta ccggcgtgat gatcaccgag
     1501 gatctcccat cccggagccg gagcgctctc gtcgtcgccc caccacaagg acgggaggac
     1561 gacgacttcc tcgccggtgt cgagtctggt gcccgccccg tccgcaccgg ggacgtgcgg
     1621 cagcttcgat ccgtacttgc cctggcggac gagcacgtcg tgccagttga gcgcaccggc
     1681 ccgcagacgg acagtcaccc agccgggccg ggccgtcggc tcgtcgacgt cttcgcaccg
     1741 gagattgcgc gcgggaccga actcgcgcag gaccgctgca tacactcgaa acccctctcg
     1801 gtcagacctt taaaagggta ggtccataac tgcccgacga caaggacgtc gatgcacgag
     1861 caataccgaa ccgcggctgg gccattctcc accgctatgg cgagcggtcc agcgaccgcc
     1921 atcccccgct gggggtggct tcctctcccg gaatggagaa cttcgacgcg atcgccaccc
     1981 attcgtggcg tcgtaggtca caatccgtcc gccaccgacc cggtccgagc tgcccggagc
     2041 acgcgtcgag cccgccccga gcagccgccc gatagagagg agccggccgt gaacggcgct
     2101 gttcaacgct atgaccgcgg gagtgcgcaa gaacgcagga tctccgcagc actagaagaa
     2161 cccctgcggc aggcacgcga ggtgctgtcc gcagccggcg acctgacccg cgctcccggg
     2221 ctcatccctg acggtggcct cgacatgcac aacgcggtcc acgcgatcaa cgccgcggac
     2281 cggattgtga ccaagcggat cgccgcgcag ccggacgacg ccgcgcagcg gcagcagctg
     2341 atcgatctgc tggtgcaagt cagcgcgatg cgcgacgcga tcagcgaggc gcacctggcc
     2401 aaccgcgcca cggcgatgac cgacgtcaac gacgcgctgc ggcagatgca ttcggccgcc
     2461 tcggtgcagc agctggtcca gatcgtgccc aagatcgtcg gtcagctcgg ctacgaccgg
     2521 accctgctct cccacatcga aggggacagg tggatcgcgc agtccgccca cgcggacgcc
     2581 gacgccgtcc tggcggaatc gatggtcgag gtaggcaccg ccgcaccggg cgtcctggat
     2641 cgcaacgtcc cggaaggtca cgtcttccgc agacgcgtgc cagtgctcgt caaggacgcg
     2701 caggcgcgtc cggaggtgca ccgagagctc aagaccctca tgcagaccag gtcctacgtc
     2761 tcggcaccgg tagtggtgaa caaccgggtc gtcggactcg tgcatgccga tgacagcgcg
     2821 agcccgggcg gcgtcgacga actcgcccgc caagtgctgg gcctgttcgc ggaagggctg
     2881 ggcttcgtgt tcgagcggac gtcgtgctac gagcggctca acgccttgca gcaccggctg
     2941 cgtgtggaga cgcgcgcagt cgccgatgcg gtcgacgtat tcgccgaatc cgactctggc
     3001 gctcctctgg ttgcgcgtca gggctctctc gacatggcgg gctcggcggg gaaatcagat
     3061 tcaacgccac cgctgccgga gctgacgcga cgcgaactgg aggtgctcgc gcgcctcgcg
     3121 accggcgagc gcaatgccga gatcgccacc cggctgttcg tctccgaagg caccgtcaag
     3181 acacacgtga agagcatcct ccgcaagctc ggcgcggaga acagagcgca ggccgtggcg
     3241 cgctaccacg ccatgagcca ctgaccggct tggagcaccg ccgcagcgaa ccacggtgct
     3301 gtcgaccgaa aatcggcgcc cgggtgcgct ggccgcgatg ccgccgctcc gcggactcgg
     3361 tgtgcacggt tgagctctcc cagaggaccc gagcggggta ggaatctctc acccaggggt
     3421 gatgcagcac acgtcctggc gacaggagac tgcattccga tccggcggtg ccggataccc
     3481 cgaacgattt cccccagcgc acgcataatc cgggagcacg tatgaccacc accgaggaaa
     3541 cgaacctcac tcctattccg gacgaaatcg ctaaccaggt cgtactgccc gaaggccacc
     3601 gcgacgagac tcgcctcttc gaggcgtacc ggtggctgcg ggagaacaac ccgctcgcca
     3661 aagtcaccgt ggagggcttc gacccggtct acctggtgac caagcacgcc gacatcatgg
     3721 agatcgagcg ccagccggac atcttcacca gcggcggtgg tgaagagccg ggctcgcaca
     3781 accccatcct gaccaatcag gcgggcgacg agttcacgaa gtccatcaac aacggcagtc
     3841 tgcgagtcct cgagaccgtc accttcctcg acccgccgga acacacgctc gtccgcgaca
     3901 tcgccgcgga atggttccgc cctgcgacgt tgaagaagtg ggaagacacc atccgcacgc
     3961 tagcccagga ggcgatcgcg aaggggttgc gttccggtac caacgaaatc gatttcgtca
     4021 aggacttcgc gctgtacttc ccgctgcacg tcatcatgag cctgttcggc gtcccggttg
     4081 aggacgagcc tcggatgatg ggcctcaccc aggacttctt cggcgcagca gaccctgacg
     4141 cggctcgtca ggacgtggcc ccgacgacgc cggaagccgc ggcgcagcag ttcgccgcgg
     4201 ccatccagga cttctacgcc tacttcgacc ggctcgtcga agaccggcgg gccacgccgg
     4261 aggacgacct ggcgaccatc atcgcgaacg cgcggcagga ggacggcgag ttcttcgcca
     4321 aggaagtcgc ctacggctgg ttcatcgcca tcgccacggc agggcacgac acgacgtcga
     4381 gcaccctgtc cagcgcgatc gaagcgctcg cgcaccaccc ggaccagctc cggcgtgtgc
     4441 aggaggaccc gaagctgatc ccacacctgg tcaacgagtc gctccggtgg tcctcgccgg
     4501 tcaagcagtt cacccgtcag gccacccagg agtacgagct gcgcggtcgg cagatcaaac
     4561 cgggcgaccg gttcgcactg ctgtaccagt cggccaacca ggacaccgac atcttcaacg
     4621 acccggagac cttcaacatc gaccgtcggc cgaacaagca catcgccttc ggctacggcc
     4681 cgcacatgtg cgtcggccag cacctcgcca agcaggagct gcgcatcatg ttcgaggagc
     4741 tgctaccgcg catcgagcgc gtcgaggtca ccggcgagcg caagctcgtg cagaccaact
     4801 tcgtcggtgg cctgaagaac ctgcccgtca acctcgtcct gcgatgagcc aagggaccgg
     4861 cagcacctcc gacgatcgcc gtgtggtgat cgtcggaggt ggccacgcag gtggcaccct
     4921 caccgggctg ttgcgccaag ggggcttcac cggcgaggtc gtactgatcg gcgaggaacc
     4981 cgacccgccg taccaccggc cgccgttgtc gaagagcttc gacgacgacg ggttggagca
     5041 gtggctgcgg gatttcgcct tctacgggga gcaggacatc gacctccgcc tcggtgagga
     5101 ggtcgtctcg ctggatcgcg acgcacggcg agtggtcacc tcctccgggc ggtccgtcga
     5161 ctacgacgtg ctcgtgctcg ccactggcgc ggcgccgcga gcgatcccgg taccgggtgg
     5221 cgacctcgaa ggcgtgctcg agctgcgcac cctcgcggat gcgcggcaac tgcgcgcggc
     5281 agtgcagcgc gacggcggaa tcgtcgtcgt cggcggcggc tacgtcggtc tggaggtcgc
     5341 cgctgcggcg cgcgcccgcg gcgacgaagc caccgttgtg gaacgcgaat cccggatcct
     5401 cgcgcgggtc gcgagcacgt ctctgtcgga gatcctgacc gagtaccacc agcggaacgg
     5461 cacggacgtt cgcaccggcg cccaagtgat cgaactggcc gagaagcacg gcagcgtccg
     5521 cggggtggtc ctctccgacg gcaccgaaat tccgtgtggg tccgtgctcg tcggggtcgg
     5581 ggcggttccg cgggatcggc tcgcagaaga ggccgggctg gtctgcgccg gcggcatcct
     5641 ggtcgactcg atgacgcgca ccagcgatcc ggcagtgctg gcgatcggcg acgtgacccg
     5701 caggccgttg cccggccgcc ccgatccggt ccggatggag agcatcccga gcgccgtgga
     5761 gcaggcgaag caggccgcat cgatcatctt gaacacgcgg cagcccagac ccgaggtgcc
     5821 gtggttctgg tcggaccagt tcgatctgaa actcaagatc gccggcctgc ccggctcggc
     5881 ggacgtgctg tgccgaggcg atcccacggc cggcaagttc gcactcttcc accacgaagg
     5941 cggggtcgtg tcctgcgtcg agtcggccaa cgcggcggcc gaattcatgg cggcgcgcaa
     6001 gctcatcgcc aacggcgccc gtatcgaccc cgccaagctc gcggacccgg aggtcccgct
     6061 ccggagcgcc gtttcgcaat gacaggagga aaaccgtgcc caaggtcgtc tacgtcctgc
     6121 cggacggcag cacgaacgag gtcgacgtac ccgtcgggca gagcgtgatg gacgggtcgg
     6181 tccgcaacaa ccttcccggc atcgtcgccg aatgcggcgg cagctgctca tgcgcgacct
     6241 gccacgtcca tctcgacgag cagtggtggg acttcttcga cgaaccctcc gacgaggaga
     6301 acgagttgct ggagttcgcc gagggagcgc agtccaactc ccggctctcc tgccagctca
     6361 tcgtcagcga cgcctgcgac ggagtccagg tcacagccct cgacaacgac ggctgacccg
     6421 cagccgaaca gatcaaggag tgcacgatgc agatcactgc ggcagtggtg gaccaggcgg
     6481 gtggcgattt caccccgcaa gaggtgtcgc taggagaacc cgcgggcgat gaggtcctcg
     6541 tcgaggtcgt cggtgccggc ctgtgccaca ccgacatcgc ggtgaaggag gggcacctgc
     6601 cgttcccgtt ccccggcgtg ctggggcacg aggcgagcgg tgtggtggtc gaggtcggct
     6661 cgtcggtcac gaaggtcggc aagggcgaca aggtcgcggt cagcttcaac agctgcggtg
     6721 cctgtgtcca gtgcaagaag gacgcgcccg cctactgcga gcagttcatg gccgccaact
     6781 tcggtggtca gcgcttcgac ggcagcagcg cgctgagccg cggtcaggag cagatcggca
     6841 gcaacttctt cgggcagtcc tcgttggcca cccacgccat cgcccacgaa cgaaacgttg
     6901 tgaaggtgcc cgacagcgcg ccgctggaac tcgtcggtcc gctcgggtgc ggggtccaga
     6961 cgggcgccgg tgcggtgatg aactcgctgg actgcgagcc cggctcgtcg gtgctggtgc
     7021 tcggcggggg ttcggtcggg ctgtcggccg tcctgggtgc ggcggcccgc ggtctgcgca
     7081 cgatcatcgt cgccgaaccc atggggcaac ggcgcgagct ggcgcgcgaa ctcggtgcca
     7141 cgcatgtgat cgacccggct gagggcacgt tgtccgaaat ggtgcgggcc gtcgcccccg
     7201 aaggcgtgga gtacgcggtg gacaccacgg cacaagtgcc cgtgatcgag caggccgtgc
     7261 tatcgctggg acagcgcggc gcgatcgggc tgctgggcgt accggccgac ccggccgcgg
     7321 cactgccgct gagcctcatt cagacgcagg tgaccggcac ccgggtggtc ggaatcgtcg
     7381 agggcgacag cgatccggac acgttcatcc cgctgttgct ggaactgcac gcggcgggcc
     7441 ggttcccgtt cgacaagctc atcaccaaga agccgttctc cgcgatcaac gaggcggtgg
     7501 cggcacagca cgagggcgag gcgatcaaga tcgtgctcgt gcacgactga ccagctggcg
     7561 ggaaaaggga ggcggaggcg ccgaccggtg ggggcacacc ggtcggcgcc tccgtttttc
     7621 gcgccgccga acagaattca ctcctgccgg tagcgcaccc cgaatccatc ccggcgacgc
     7681 gcgacgacat ggcgtgcaac gccgcgacgc agacgtcccg gcccaacgaa tctgtccgcg
     7741 taggacttgg tttggggcgt tttcggcgca cgcgcgcgaa aacatgcgtg actcaccggg
     7801 tgcatcagtc gcgtgccagc gcggtgacgg agcaaacaag cctgtgtcgc agcgccatgt
     7861 gcgcggtctt cgaacgaggc cgtgttcggc gaaggcgtca tgacggcgcg cgccagaatc
     7921 cctcgttccc aacgagttcg ccgcaggcag cacgacccgc ccgtgcattt ccccggcagt
     7981 gcgggacatt tcgtcccaga cacgaaggag cgcccgaccg gcgaaccggc cgagcgctcc
     8041 tcgcgcgctc gaactactgc gagctatcca ggtacaccga ttggatccga tgataggccg
     8101 ccagcccttc cggaccgagc tcgcgcccca tcccgctgcc cttgatcccg ccgaacggcg
     8161 ccgtggggtc gggcaggtag gcgttgatgc cgatggtccc ggtctgcacc cggcgggcga
     8221 cgtcgagccc cttcgccggg tcgccggtga acaccgagcc accgagcccg taatcgacct
     8281 cgttggccag ttgcacggca ccgtcgacat cgtcgtacgg gatcacgctc agcaccgggc
     8341 cgaagatctc ctcctgggcg acggtggtcc gattgtccac gtcggccagg atggtcggtt
     8401 cgacgaacca gcccttgccg agatcgttcg gccgcccgcc gccagtggtg atccgtgcgc
     8461 cctcgtgctt gcccttggcg atgtagccct cgacccgctc gcgctgcttg gcggtggcca
     8521 tcggaccgat ctgggtcgcc gggtcgagcg catcgcccac gctcaacgac gaggccagct
     8581 gggtgaagat gtccacgacc tcgtcgtatc gcttgcgcgg cgcgaggatc cgagtgcccg
     8641 cgtagcaagt ctgcccgttg ttcatcagac acgcgctgaa cagattctcc acattggacg
     8701 ccaggtccgc gtcctccagg acgatcgccg ccgacttgcc gcccagctcc agcgtgacgg
     8761 gccgcagcaa ctccccgcag cgctgcgcga tggcgcgccc cgccacggta gacccggtga
     8821 acccgatctt gtcgaccttc gggtgctcga ctatgtatgc accgatctcc cggccaccgg
     8881 gcacgatgct gagcacaccc ggcggcacgc cggcttcctc ggctgcctcc gccatcaggt
     8941 aactgtccaa caccgtctcc ggggacggct tcatgaccac cgtgcacccg gcggccatcg
     9001 ccggggcgat cttgaagaag gccagcgact gcgggaagtt ccacggcacg atcgcgccga
     9061 ccaccccgat cggctcgcgc cgcaccagcg tggtgccgcc gaggaggccg ggacgacgct
     9121 cttccacctc cgtgccctcg gcgaggtcgg cgtagtaccg cagcagcatg gcggggaaaa
     9181 cagcctccag ctgttgcccg atcgccaccg gcatcccgtt ctggccgctg atgcggcgca
     9241 ccatctcctc ggcacgactc tccagcgatg ccgcgaagcg gcgcatgacc tccgcccggc
     9301 gcgaggctgg ccagtgcgcc caccctgagg ggtcgtcgaa cgccgctcgg gcggacgtca
     9361 ccgcacggtc gacgtcggcc tcaccggcgt gcggcacctt cccgaggagc tcctcggtgc
     9421 tggccgagac cggttcgatc gtgtcggtcg actgcggtgc tacccactcg ccgccgatgt
     9481 acagcttgtc gtagaccagc ttgtccatcc gcactccttg cgcctgtcgt tttgtgcaca
     9541 gcgggtccag tacgcggatg ctgcggaccg catccgcaac gaacggccgg accggccgaa
     9601 ggcccgaatg gcggtagccg cacgggatct tgcggcgttc ggtctcgcgg tgccgcgctg
     9661 cggccagagc cgctttcccc ggcatgcgtc tgcagttagg ccttggccgt tccgccctgg
     9721 atgccgttct tccgccccgc tggcccaagt ctgatcgcgc agggggtgcc gcgcctcacc
     9781 cctgcgagag atttttcgcc ttcccaaggg gtgttgttgt gcccgcgacc tgggatccga
     9841 cggcacgttc agcgaagctc gccgcgggta cgacggcaga cccctgctgc gcacgcagca
     9901 ggttggccga gccgaccgat tgaaattttg gtctgaccat attattttta gcttgttcga
     9961 gctttccgca gggtgctgtc aagtccgaaa gagtgttccc atgctgccaa cggcgacagt
    10021 tcaggaccgg tacaccgacg aagacgcgaa acgcttctac cgagccggtt tctggcagga
    10081 cgcgaacctg ttcgacctcg tcgaagcgca ggcgcaagtg cgcccggaca agatcttcgc
    10141 gtccgacggg acgacgaacc tgaccttccg cgacctccgc gaccgcggcg cgcggctggc
    10201 gctcggcctc cgccgcctcg ggatccgccc gggcgaccgg gtggccgtcc aactgcccaa
    10261 ctggagcgag ttcacgctga tcgccacggc gctgggccgc atcggcggca tcctcgtgcc
    10321 gatcatgccg atcttccgcg aggacgaggt cgagtacctg ctcacccact ccggcgcgaa
    10381 agcggcgatc acctgcgagc agttcaagaa cttcggatac gtggagatgt actcccggct
    10441 ccgctcgagg tgcccggaac tccaggagat catctcggtg cgcagcaccg gcacggacgg
    10501 ccggtgcatt ccgctcgagg agctggtcgt ctccgatcag gtcgccggcg aggatccgga
    10561 actcggcccg cacccctcgc ccgacgacgg attcctgatc gtctacacct cggggacgac
    10621 ttcgcgcccg aagggctgct ttcacaccct caacacggtt cgcgccagca gtgcggccat
    10681 cgcgcgcagc ctggattacc gcgaatccga cgtccaattc ggaccgtcgc cgatcacgca
    10741 ctcgaccggc ctggtcacca gcatgttgct cccactgcag agcggtgccg catcgcacct
    10801 gatggacgcc tgggaaccga atgcggcgat gcggcgaatc gctgagtacg gctgcacctc
    10861 cgcggtcacc gcgaccgcgt tcctggagat gctgctgaac gtctataacc ccgaccagca
    10921 cgatccgagc agcatgcgca tgtgggtgtg cgcgggcgct ccggtaccgg catcggtcgt
    10981 gcaccgcgct gaggagatgc tcggcggctg ccggatcctg agcctctacg gccgttccga
    11041 gaacttcctg acgaccatgt gcactgtcga cgacgcgccg gagcgatctg cgacctcgga
    11101 cggggcggcc gtgaaatccg ccggggcgag cgtgcaggtc gtcgacgacc gcggcgagga
    11161 ggttccccgc ggcacggagg gcgacatcgc ctacaagggc cccagccaca tgatcgagta
    11221 cttccgcgac cccgagcaga ccgcggccct gttcacaccg gacggatact cccgctccgg
    11281 ggacctcggg tacatggacc aggacgggta cgtccgggtc accggtcgct cgaaggacat
    11341 cgtcatccgg ggcgggttga acatcagcgc ccgcgagctg gaagagctcc tcgcggagca
    11401 cccgttggtc gccaacgtcg ccgtggtggc gatgcccgat gcccggctgg gcgaaaaggt
    11461 ctgcgtgtac gtcgtgccgg ccgagccggc ggaccggccg tcgttggagt cgatcgtgtc
    11521 ctacctgcgc gggcggagag tcgcgacccc gaagcttccg gaacgcctcg agctggtcga
    11581 ggaacttccg ctgacggcga ccggcaaggt gcagaagcac gtgctgcgcg acgacatcaa
    11641 gcaaaagctc caggacggcg gggtcgtcta aaggcgcgcc tcgattccga actgggcgcc
    11701 accgtcgcgg tggcgcccag tttcgtgctt cgcacgtcct cggacgcgaa acgggggaag
    11761 ggctacaagc ccttcccccg cctcgggtgc aggttcacat catcggcgta ccaccgggga
    11821 gacgatcccg cggttgcgga tggcagaggc gttcagccgc cgacgcacat ccgcgtagca
    11881 ggcgcggcag agctcccccg gaacgaacag ctgccacgcc gagttggact ggatgcactg
    11941 ggaatcggcc atctcctggc agattccgtg gtgcccgacc tcgttgcaca ggcatgcgca
    12001 cagccgccac gtcatcacgc accaccgttc agctcttcag ctcggcgacc gcgcccgtca
    12061 gttgtggagc gacctggaag aggtcaccca cgatcccgaa gtcggcgatc tcgaaaatcg
    12121 gcgcctccgg atccttgttc acggccacga tcgtcttcga ggtctgcatc ccggcccggt
    12181 gctggatcgc cccggaaatg cccagcgcga cgtacaggtt cggcgagacg gtcttgccgg
    12241 tctgcccgac ctggaactgc gccgggtagt acccggaatc cacggccgcg cgcgaggccc
    12301 cgacagcggc acccagcgaa tccgccagct gctcgaccac ctcgaacgac tccgccgaac
    12361 cgacgccccg gccgccggag acgaccaccg gcgcctcggc caggtccggg cgctcccccg
    12421 cctccgcagg ttggcgcccc gtgatccgcg ccgccttgcc ggcaacgccg atggccacct
    12481 cttccgtgat cggactggat ggttcgtcca cgggctcgat gctgcccggc agcaccgaga
    12541 gcacggacac tcccgcggtc acctcggcct cggccaggta cgcgccgccg aacagcgaat
    12601 gcgacgcgac gccctcgggt ccgaggtcca cgacttccga cagcagcccg gaacccagac
    12661 gcacggccaa gcggcccgcg atctccttgc cgtcgaccga cgcggggacg agcaccgccg
    12721 acggctcgcg cgtggcgacc aactccgcga ggacgtcgac ctccggaacc agcaacaacc
    12781 gtgctgcctc gggcgattcg gccgcgtaga tcttcgcggt tccgtgcgcg gtgagcgcat
    12841 cagctacctt cgccgccacc ccgggttcgc cgacgactac cgcggatggc tcgccgagcc
    12901 agcgagccgc ggtcagcaac tcggccgtga ccttcttgac ctcgccgtcg acgtggtcga
    12961 cgaggactag aacttcggac attactgcgc tcctcctcgt gcggcccgga tttcagacca
    13021 gcttctgcgc tgccaggtac tccgcgatcc gagtgccgcc atcaccggcg tcgtcgagct
    13081 tctgcccggc cggcttcggc gggcggggtg cggcggcgag gacccgggag ccggcgtgag
    13141 cggtacccac ctcagcggcg tcgatgcccg catccgccag cgccagcacg gacaacggct
    13201 tcttcttcgc cgccatgatc cccttgaacg acgggtagcg cggctcgttg atcttctccg
    13261 tcaccgagag caccgccggc agttccgctt ccagttgcag caccccggcg tcggtctcgc
    13321 gggcagcgcg cacggttgac ccgtcgagtt cgacgctgcg ggcatgggtg agctgtggcc
    13381 accccagcag ctccgcgagc atcgctggca ccgccccact ccggccgtcg gtggcctcgt
    13441 tgcctgcgat gatcaggtcg accgcctcca gcgtgccaat caccttcgcc aacgcccgag
    13501 cggtcgccgg tgcgtcggtt ccccgcaacg cctcgtcgga gaggtggacc gccttgtgtg
    13561 cgcccatgga cagcgccttg cggatcgcat cggtcgcgcg gtcgggcccc atgcagaccg
    13621 cggtgacctc tcccccgtgc gattcgacga tctgcagcgc cgcttccacg gcgcgctcgt
    13681 tgatctcgtc caggaccgcg tcgaccgact cgcggtccag tgcgtgatcc gtctcggtca
    13741 acctgcgttc ggagtaggtg tccggaacct gcttgaccag cacgacaacg ttcaacagtc
    13801 ccacgcccta actcgtcgag agtccgggct cgggtcgagt cgcggggctc gtacctccgc
    13861 tcggaccagg tgtgcccggc acccgcctac caataagcct aaaagtaata aaggactgac
    13921 caaaacacaa gtgcttggtg ttgcttaggg tcctcaatat gatcggttgt ccgataatgt
    13981 gaaccagcaa ccgcggacat gagacgaacg acggaggctc acgtgccgcc cacacgcgca
    14041 caccgcgccg accctcccgg aacgcgaagc cccgagcacc ggaccgtgac ccgggtcgcg
    14101 gccatcctgg aggccgcggc cgccgccccg gacggcctgc gcctcgggac gctgcgcgaa
    14161 cttctcaacg cgccgaagtc gtccgtccac ggcctggtga aagggctggt cgcggtcggt
    14221 tacctcgccg aacaggacgg ccggtacacc ttggggcctg cgatggcgac cgtggctgcc
    14281 gcagcgcgcc cgaccgtggt cgacatggcc cgcgccccca tggagaagct gcaccgccag
    14341 ttcgacgaaa cggtcatgct cgggtcgatg accggcgaga cgctggtcta cctcgacacc
    14401 atcgagtcga cccaggccat ccggtattcg ccgccgaagg tgcggcggca cttcgagaac
    14461 ccgtcggcga tgatgaagct gcacctcgcc gaacggactc cggagcagct cgacgactac
    14521 ctgctcgcac gcatctcggt tccccagcgc cgcaaggagt tgtccgcgga gctggcagcc
    14581 gtgcgcgagc gcggagtggc cttcaaccgc ggtgacacgt tccccgacct cagcgccgcg
    14641 gcgatcgggt tgaccgagcg gggcaaactg gtggcgtgca tcgcggtcgg cgggccgagc
    14701 cctcgcgtca acccgctgct cgacgagatc gccgcggcgc tgtcggaagc cgccgcagag
    14761 atctcgcaac acctcacctg accccggact tccccagcac ctgcggaaaa gccgtcgcag
    14821 gtcaggcgtg gatcgcgggc cggacggcaa gctccggcag tcgacccgaa tcttgacggg
    14881 cgtcatctat ggtcttatgg tccgaccgtc tccatatagg aatgtcgatc tgatgtaaga
    14941 acgcgcgttt ggttcgaggt cactgcgcgc ggtgtcgccc gctccgcgcc cagccttgat
    15001 ctgcgctgac gccatcggcg actgcgcacc acctctcgcg gggttcagcc tgcgcgtcct
    15061 caccggagtt cgcggcgcac cgcgaactcc gctcggcatc gtcgctactg acgctgctga
    15121 tcccagaacc agcggccgga actcgcagat tttcggcgca ggaagcgcag caccagcgaa
    15181 caggaaggcc ccgatcgatg gctgatcgtc gagacgccca cagcgcgagt cccgatcccg
    15241 gtccgctgca cggcgtgacg gtcgtggcgc tcgagcacgc cgtcgccgtc ccgatagcca
    15301 cgcggcagct cgccgatctg ggcgcgcgcg tcatcaaggt cgagcgccgc gacggcgggg
    15361 atttcgcgcg gcactacgac gatgtggtcc gcggcgggct gtcgagcgtg ttcctgtgga
    15421 ccggccgggg caaggaatcg atcaccaccg acctcaagca gcccgagggg cgcgaggtgc
    15481 tgcacgcgct gctcgccgag gccgatgtgt tcatccagaa cctcagcccc ggcgcggtcg
    15541 accgcatggg cttcggggac gaagaccttc ggacactgca cccgcggctg atcgtcgtgt
    15601 cgaactccgg ctacggcgaa cccggcccct actccggacg gcgggcctac gacgcgctgg
    15661 tgcagtgcga gtccggagtg gtggccgcga ccggaaccgg ggacgagatg gtcaaacccg
    15721 gcttctccgc cgccgacgtc gccagtggca tgcacatgta ctccgccgtg ctcatggcgc
    15781 tctaccagcg cgaacgcacc ggacagggca cgatcgtcga ggtcgcgatg ctcgacgcga
    15841 tcaccgactg gatcgccaac cacctctatt acacccagca caacggagcg ccgcccgagc
    15901 gcgtcaacat cggccacccc tccttggtcc cctacggggc tttcgcgacc gcggacggcg
    15961 atcaagtcgt gatcggcgtg cagaacgacc gcgagtgggc gcggttcgcg cgcaccgtgc
    16021 tgcaatcacc cgcactggtg gacgatccga gcaccgcgac cacgatcgcg cgggcagagc
    16081 accgcgcccg ggtggacgcg ctggtgaacg acgcgacgtc ccgacttggc accgcgaagt
    16141 tgctgcaact gctcgacgaa gcccagatcg ccaacgcacg ggtgaacagc cttgccgaag
    16201 ccgccgacca cccgcagttc accgcccgcg acaggtgggt cgaggtggaa tctccggtcg
    16261 ggcctgtgga caccttgcga caggtgatcc aggagcgggg caagcagtac cccgccggtc
    16321 cggtgcccga gctcggcgcc cacaccgacg cgctcctcgg cgagctcggc tactccgcgg
    16381 ccgccatcgc cgacctccgg cggcgcgaag tcgtctgacc gcgaattccg cagcacagcc
    16441 tgaaaccccg accgagaggc agactcgcat ggtttcgttc gctttcaccg aagagcagca
    16501 agacttccaa cggacgctcg ccgacttcac ccgcaggaat ctgctgccgg gctatcgcga
    16561 ccgcgccgcg tccacgacgt tcccgttcga cgtcctgcgc cgactcggcg agctcggcgt
    16621 gctgggcatc gggctgcccg agaagttcgg gggcaccggt caggaagacc cgatcatgct
    16681 gggcttggcg accgaaacgc tggcctacgg cgatgtgaac ctggcttcgg cgccggtgca
    16741 gaccggcctc atcgcctccc agctcctgca cgcggacgag gcggtgcagg aacgctacct
    16801 gccgcccatg atcgaagggc gggagacggt cgcgatcgcg ctcaccgagc ccggttccgg
    16861 ttcggatgcc gctgcgatgt ccacagtggc ccgtccggtc tccggcgggt ggcgcctcag
    16921 cggtgagaag accgccattt cctgggcctg caacgcttcc gccgcgctga tctacgcgcg
    16981 cgatcccggc agcacacgtt cgtccggagt gagctgctac ctggtcccgc tcgattccgc
    17041 gggcgccgcc gtgcaccaca tgccgggcat gggctgtctg ccgctcgggt ggggttccat
    17101 ccacctcgac gacgttttcg tgccggcgag ccacctcgtc ggcgagccgg gcacgggttt
    17161 ccaggcggtg atgagccact tcgacttcag ccgcgcagcg ctgggcctga tgtgcctggg
    17221 ggccgcgcag gtgagcctgg acgaagcggc cgcctacgcg acccagcgcc acgcattcgg
    17281 caaacccatc gccgaaaacc agggagtctc gttccccctc gcggagcacg cgacgtacct
    17341 cgaagccgcg cgatggatgt gctaccacgc cctgtggatg cgcgagcaag agcagccgca
    17401 cacgtcgctg gcctccatga gcaagtggtg gcccccggtc gccgcgaagg acgccgtgga
    17461 ggccgccatg aagatccacg gcaacctcgg ctactccacc gagttcccgt tgcagcagcg
    17521 ctaccgcgac gtcatggcgt acctggtcgc ggacgggacc gccgagatcc agaagcggat
    17581 catcgccaag gacgtgctcg agcgcggcag cgtggtgttc tagcgcggcg agtcggcggt
    17641 cagttccagg gcgatgtccg cgatcatgtc ctcctggccg ccgaccagac ctcgccgacc
    17701 gacctccacc aggatctgtc gggtgtccag cccgtgctcg gcagcggcgc gctcagcgtg
    17761 gcgcaggaag ctcgaataca cccccgcgta cccgagagtc agcgtctccc ggtctacccg
    17821 cactgcgcgg tcctgcaacg ggcggacgat gtcgtcggcg gcgtcctgca aggcgaacag
    17881 gtcgcagccg tgctgccagc cgtgcaggtc ggcaaccgcc acgaacgctt cgagcggaca
    17941 gttgcccgcg ccggcgccgt gccccgccag cgaggcgtcc acccgggtca cgccctcttc
    18001 caccgccacc accgaattgg ccacggacaa cgacaggttt tcgtgagcgt ggatgccgat
    18061 ctcggtggcg tcgtcgagca cgtcgcggta cgcgcgaatc cgttcccgca cgtcccgcat
    18121 cgtcagtcga ccaccggagt cggtgacgta cacgcagcgc gcgcccgcgg actccagctg
    18181 cacggcctgc ttcgccagct cggtcggcga ggccatgtgc gacatcatga ggaagccgga
    18241 cacgtccatg ccgagatcgc gggccttgcc gatgtgctgg gcggcgatgt ccgcttcggt
    18301 ggcgtgcgtg gccacccgca ccgagcgcac gccgagctcg tgggcgcgtt cgagttcctt
    18361 gatggtcccg attcccggca ggagcaacgt ggtcagcacc gcccggttga cgacctccgc
    18421 tgcggcggag atccactccc agtcggtgtt gctcccgggg ccataggtca cgctcccgcc
    18481 agccaagccg tcgccgtggg ccacctcgat ggcgtcgacg cccgcggagt ccaatgcggc
    18541 ggcgatcgcg cgcaccctgt ccggggccag tcggtgccgg atcgcgtgca tgccatcccg
    18601 caacgtgacg tcctggatgt acagacgggg cgtgctctgg tgcggtgtgc tcacgtgtcc
    18661 acctcgacgc gctgccgggc cgcgttcgcg gcgagctgct cggccgtgcg cagtgcggcc
    18721 gaggtcatga tgtccaagtt gcccgcgtag gcgggcaggt agtgcgccgc gccctccacg
    18781 gcgaggaata ccgagacctt ccagctcggg cgcggcgcgg cgtcgatcag cgtgcccagc
    18841 ggctcgtccg cggcgacggg cgtgatctgc acctgctgct tgagccggta gccgggcacg
    18901 tacctggaaa cctcggcgac catccgctcg acgctgtccc ggatcagttc ggggtcgccg
    18961 tcgcccgcca ggcacaaaac cgtgtctcgc atgatcatcg gcggttcggc cggattcagg
    19021 acgatgatcg ccttgccgcg gtccgcgccg ccgacgacct cgatcgcctt cgcggtcgtt
    19081 tcggtgaact cgtcgatgtt cgcgcgggtg ccgggccccg ccgatttcga ggcgatcgag
    19141 gcgacgatct cggcgtaccg gaccggtgcg acccgggaaa ccgctgcgac cacgggaatc
    19201 gtcgcctgtc cgccgcaggt caccatgttc acgttggtgg cggttcggtg cgcgtccaga
    19261 ttcacggccg ggaccacgaa cggcccgatc gctgcgggcg tgaggtcgac cagcagcttc
    19321 ccgtggggct ccagcagcgc cgagttccgc tcgtgagccg ttgccgaggt ggcatcgaag
    19381 acgacatcca cgtcggcgaa ctcgggcata ccgagcagtc cctccacgcc acgatccgtc
    19441 gtggagacgc cgagccgacg cgcgcgggcg agcccgtccg aggtgggatc gactcccacc
    19501 atcaccccca tgtctaggga atcggacagc ctgatcacct tgatcaggag gtcggttccg
    19561 atgttgccgg agcctatgat cgcgaccttg gtcttcacgt tgctcccccc gcgttcccgg
    19621 agaattctgc ggtgacggtc ccgagcccgc tcaacgtggc ggagaaggac atcccggcgc
    19681 tgacgggcac catcggtccg agggctccgg acagcacgat ctccccgctg cgcaacggca
    19741 tcccgagttc gtagcaggtg cgggccagcc acagcagcgc gttcagcggg tcgccgagac
    19801 aggccgcccc gcttccgctg ctgaccgtcc ggccctgacc atcgaccatg gtcatctcca
    19861 cttcccgcag gtccgcgccg gcgaagtcga gctgggtccc gccgaggacg aacatcccgc
    19921 tcgaagcgtt gtccgcgacg gtgtcgggga agctgatgtc ccaccccgcg atccggctgt
    19981 ccacgatctc cagagcaggc accatccccg cgacggcctc gcgcaccgag gcgagatcga
    20041 tgtgcgggcc gtcgaggtcg ctgccgagca ccaacgcgat ctccgcctcg atccgcggtt
    20101 gcagcaactg ggcggtgtcc acggcggttc cggcaggcac agccatgtcg tcgaacagga
    20161 caccgaagtc gggctggtcg actcccagct gctgctggac cgccggggag gtcaggccga
    20221 ttttgcggcc gacgattcgc ccgccacggt cgctccggtg ccgagtcagc attgattgga
    20281 cggcgtaggc cgtggtcgcc gccgcgtcgg gcagtaggtc gcggacgggc gcgcacggca
    20341 cgcgggtctt ggcggcgtcc agcagacgct cggccgccgc ctcgattccg gtcagctcgg
    20401 gcacgattcc ctcggttcgt ctcgatgcgg cggatcagcc gcgtttgatc aggggcagct
    20461 cggggcgccg gtcggagacg ccggcttcgt cggccagctc tcccggcacg gttccgtgcg
    20521 cgaagaactc gtggaagacc gggttgaaca ggtccggccg gtccgtctgg ccctggtggc
    20581 cgcagtcgtc ggggtagaag aactgcacgt tgggcaggtg gtcctcctgg acgtgccccc
    20641 actcgaccgg ggtcaggatg tcctgcctgc cgtagaggta gatcccgggg atctccagcc
    20701 ggtccaggcg ccccttggtc gccagccgcg cggcccggtt ctggtcagtc cacgggacga
    20761 tgtggcggta ctgcaacagc gtgggccaga actgctggtg ggcctccaac cgctcggcgg
    20821 ccgacaagta gcgcatttcg acgaggtcgt cgctgaccgc ctcgggccgg tggatgatcg
    20881 cctccatcat ggaccgcatt ccttcgcggg tgccgtcgta ggcagtcatg tggaactgcc
    20941 cctgcggcgg cttgatctcc tccgggacga cgtcgccgac atcgccggcg atgagcgcga
    21001 agctcagcac ccgctccggg tgcgccacgg tgtagttcac cgtgttcatg caacccatcg
    21061 agttgcccgc caggtgaaag cggtccaggc acagcgcgtc ggcgaagtcg taaatgaagt
    21121 cgacgaagtc ctccatgccc cgcggccagt gctccggcct cggatcggat aggccgaacg
    21181 ccggcatgtc cgggcagtaa acccggaacc cgcgctcccc caggtaggac gccatgaacc
    21241 gccacccggc caggcccgac gatcccggca ggccgccgtg cagcagcacc acggcaggac
    21301 ccgtgtcacc cgaggtcatg tagtgggcac gtgcaccact cgcgagacgc acccaccggc
    21361 tcgccatgcc cggtgtctcg acgagattct cactggtcaa cgccatcagc gtgctccttc
    21421 gcagctagtt cgagggggat cggtggcgag ccccagcaat tcggcggcat tgcgggccag
    21481 gaaaggagga tcgacgtgct cgggcagcac gccggtctgc tgtgccgccc gcaccgagtt
    21541 catcgatttc gccatctggt ccggaaagaa cggcgcatcg ctacccaaga ccaaccggtc
    21601 ggcaccgaac cggtgcacga gcagccctag atgctcgtcg tcgaaaacga gggtgtccac
    21661 gaacaaccgg cgcgccaacc ggtcccggtc cgcgatgtcg ccggtcaggt ttgctgcgag
    21721 ccgcaaccgt gggtacgccc acgggaacgt tccgcagccg tgcgcgagca cgacgcgcag
    21781 ttgctcgcgt tcggccaaga ctcccccgaa caccagcgcc gacgctgcga tggccgtgtc
    21841 ggtcagcatt cccagaccga ggtcgtacgg agctccggcc cggcgaacca cgtcccgtcc
    21901 gccctgcacc gggtgcacga acaccgccga tgccgtggca tcgcaggcat cccagaaccg
    21961 gtcgagatcc ggggcgtcca agtcgagctc gccgatccgt gttccgactt cgaccccgtg
    22021 caggccgatc tcccggcacc gccggagttc cgcgatagcg gcgtcgatgt cgcccagcgg
    22081 caggcatccc agtccgagta gacgcccacc ggactgctcg cacgcctccg cgatcgagtc
    22141 gttggtgctg cgcgcgcatt ccggatccgc gccggacgcg tgctccatga cgaccgggac
    22201 aggagagacg acctggtggg agagcccggc ccggtccatt tccgccaagc gcagattcac
    22261 atcccacagc accggctcga cggcccggaa cgtcgtgtca ccgcgcatga tctgcccgct
    22321 cccgtctccg tcgatcacga gccggggagc gtcggtatcg tgccggaccg gggtttctcc
    22381 cgcgtcggga ccgaaatggt gcgcgtgcac atcgacggcc gtgagctcgg gcatggacag
    22441 catccctgcg gttcggagga atcgtggccg cgacgctaaa ggcacccgcg ccgcggtggg
    22501 gctgatgttt cagtggccgg aaccgaaacc cgtgcggcgc aaggaaagac ctgacaggcg
    22561 cgatcgggtt aagctctcca tggtcccgat cggcgccgca cggcccgcgc tcgtgcgcgg
    22621 gtttgcacga cggcgggcag cacaaggagg tgcgccgtga ccacgatgca cgagcagaag
    22681 caggaatccc ctcccacttc gatcctgtcc aaagcgttcg acgtgctggg agcattcggg
    22741 cccgaccacc gggtcctcac cctcaccgag atcgcgtgcg cgagcggtct gccgaaatcc
    22801 acggttcacc gcttgctcgg ccggctgacc gagctcggtg tgatcgagcc gcattgcgcg
    22861 gggttcaagg tcggcttacc gctgcggcgg ttcgcttcgg cgatgccgat cgaaagcctg
    22921 cggcagtcgg cgctgccaca cctgggcgcg ctgcaccact ggtctcgccg gcacgtgcac
    22981 atggccacgc tgcggggcga acgcgtggtg ttcgtcgagc ggatgatggt gccggggcac
    23041 gagctgccgt cggccgaccc cggcacggac ctgcccgcgc acgccacagc actgggcaaa
    23101 gcgttgttgg cgttcgcacc accagatgag gtcgactccg cgttggcagg cccgttgcac
    23161 gcggtcgcgc cgaacacgat cacggatgcc gcggagttcc gcgccgaact ggccgaggtt
    23221 cagcggaacc ggttcgccgg tgcgcgcggt gaatcgcacc ccgacgtttg ctgcctggcc
    23281 gcgccggtgc tgatccgcgg ccgcgcggtc ggggcgttgt cggtgtcctc gacggccgga
    23341 gaacgcaaca gcgaccgggc actcatcgat gctgtgcgcg tgaccgcgga ccggatcgcc
    23401 acggacaatg cgaaggtgct cgccgacggc cacgaggact ggttcccagg tcggctgtga
    23461 gcgcccgtcc gctcaggagt cgcttccgag tggtctgcgt ggcggtgccg gttgcttaca
    23521 tggtcgttgc tggagcggct ccgccgctga caagacaaag accctactga aacgacgcat
    23581 caagagaaga tcccgaacgg cttgttcgag ttgaacacgt ctgtggtcac catcgtcgac
    23641 cagcgccgct gcaagccgag ttcctgcacg gcgccgaaca agcagaacca gttcagcatc
    23701 tcgtgctggc cggccgccac gacgtcgcgc ccgctcacca cggcgaggtc gtcgaagcgg
    23761 ccctcgacca tcagctggta gagtcggcgg tcggcggcgg tgtccggccg tatgtgccag
    23821 agggcatcgg tcaggaaggc gtgcgaccag ctcgacgagg cgatgaacgc gacccgctcg
    23881 tcgttcccgg cgaagtgccg cgcgatcgcc cgtcccacct cgacgcagcg ggccgggctc
    23941 gggccggacg ggtcgagctc ctcgctggag atgtcggcga accgggccaa gccgcccttg
    24001 cgcgcgatgg cgtgctcgcc gtagcaattc accgtgatcg gcagcagccg gtacgcgaat
    24061 cgcgctcccg cgtggtcgta gtccaggaac agctgggtgt tcaggatggc gtgcgggaag
    24121 tgcgctccat cccgcttgcg gtacgaatag gccatgtcga cgccgtcgtt gatgagcccg
    24181 tcggcgagcc tgcgggcgat cgcggagtca ccgcggaggg tgatgcggaa gtcgtcgggc
    24241 agtccccagg cgttcgggct gccgcgctcg ttcatcacct cgaacgccgg cacctccagg
    24301 tcgtcgtagg cgagcacgca gaacggtggc acgacctcct cgcggaagtt ctcgtactgg
    24361 tcgtcacccc agaccacgac cacgtcgggg gcgaactcgt cgagggcggc gcggcaccgc
    24421 gcgagaccgt ccagcaggtg ggcgcggtgc ccggccgctg cggagcgccc ctggtccgcg
    24481 ccccactccg cgcgcatgga cgccggccag ctcgccgggt ccttctcgcg ctcggggata
    24541 tcggggtcct gcaacgtcca cctgagcaat ccggccatgt gctcgtccgt gccagccagc
    24601 aacgggtagt gcgtcatgcc gaggccgagg aatcgactca tcgtcgttct gctccgttct
    24661 gggttccccg cggtgtcggt gcgacgtgcg attccggcat gacgacgacg ctggatgtgc
    24721 ccaggtgcca ccaattcgtc ccgtcttcgt cgggctcgtg cgggagcacc tcgacggtcg
    24781 tgaacggaat cccattggga tcgtgcgtgc ccacgatgat attgatgtcg cagccgaccg
    24841 accggatgtg caggatcttg tccggcccgt cgggttcgtg gtgatcgacg atgcgcatcg
    24901 gtgctccgtt cgcgggtggc cgcagcggtg ccggaatggc ggcacgtcgg gtttcgctcg
    24961 acccggacgt tagccatctg ctgccggccc caggaacagc ggttccagcg gccggaacca
    25021 ggtcaccgcg atgcagcggc gattcctagc ctgggctcct cccccggcct cccggaggtt
    25081 ccgggtgtgg gcaacgaagg ccgcactgaa acggagacgg gcatgcctga tcctctcgtg
    25141 atcgacaatc gcaaggactc gctgttccaa gtcgaccgcg aggtgttcac ctcgcaggag
    25201 gtcttcgaac gggaacgcga gctgctgttc ggcccgtctt ggttgtacgt cggccacgaa
    25261 tccgagatcc ccgagcgcaa cgatttccgc acccgcgacg tgggcggccg gtcgatcatc
    25321 ttcaaccgcg accggcgcgg cgaggtccgg gtgctgctca acacctgtct gcaccgcggc
    25381 gcatcggtct gtcggcatcc ggccgggaaa gcgaagatct tcacctgctt ctaccacggg
    25441 tgggcctacc gcaattcggg cgagctggtg aacgtcccgt ccgcggagga ctacgccgcg
    25501 tcaccggccg acgtgtacgg cggtctgcac acgccgcgca tcgagtccta ccgcggcttc
    25561 tggttcgtga acttttccgg cgacgccccg gatctgcgta gctggctggg caccgcgaca
    25621 tacctgctgg acctggccgt ggaccagtcc gaggacggca tcgaggtgct caccggcacg
    25681 cacaactacg aactgcacgc caactggaag ctgctggtcg agaacagcgt ggacggctac
    25741 cacgcgaaat cggtgcacca cacctacttc gagatgatga tggaactcgg gcagaccccg
    25801 ccgatgctcg gcgatgccga caccaacggc gtgccaccgg ccgggctggg aaccgagttc
    25861 gacaacgggc acgccacgct gatctacccg ggcaacggcc ttccgctggc caacgagaac
    25921 gtcgtgcgca acttggccga gctgcgggag aaagcggtcc agcgatgcgg cgagtcctac
    25981 gccaccgcgg tgttcgacct ggcgcgcaac agcatcttct tccccaactt cgtgctgatc
    26041 gacctgaact tcggcatgat cctgcgcacg atcatgccgg tcgcgccgga ccgcaccgaa
    26101 gtcaccagct ggcacatcgc gccccgcggc ctcgacggcg aatccctgca gtaccgcatc
    26161 gacaacgcgc tcacgttctg gggaccggcc gggctggcca cccccgacga cgtcgaggcg
    26221 ctcgaacagg cacagcgcgg attcagcgcg cgcaaggagc tgcgctggtc cgacatctcc
    26281 aagggcatgg gcaagacccg cccggctgcc aacgacgaac tccagatgcg cgcctggtgg
    26341 cggcagtgga acgcgctgat gaccggcgag cggttgccgc gcgaggtcga cgagttcgtc
    26401 cccttcgaca cccgcgcacc ccagggagcc tgacatgacc gctgccaccc cgaacgccgc
    26461 gaccgtgacc cgcagcgagg tcgaggactt cttgttcctg gagtcctcgc tactcgacga
    26521 atggcgcctg gaggagtggg tcgagctgtt caccctcgac tgcacctacg aggcgccggc
    26581 caccgacgcg cccgcgtccg atccgggtca gacctggtcg ttgatccacg accggcggac
    26641 gatgttggaa cagcgcgtga tccgcctcaa aaagccggag gcgcacgccg agttcccgca
    26701 ctcgcagacc agccgcatcg tcggcaacgt ccgcatcctc gaccgcggtc cggatgccgt
    26761 gtcggtgtcg gcgagcttcc tcgtctcccg catgaaggcc ggaaagttcg accagtacgc
    26821 cggccactac tactacgacc tggtgcaggg cgaggacggg ttcaagatcc ggcgcaagaa
    26881 ggcggtgctg gcccacgacc gcctcgctcc ccagggcaag atctcgttcg tcctgtgacg
    26941 aacggcgcgc gtccacacca ggaggattta ccgatgagcg agccgagcgc ggtttcggac
    27001 cgggttctcg cgtgcgagac cgacgaactc gccgacggcg agtcgatgac ggtcgagccc
    27061 gacaacggcg aggcgatcgc ggtctaccgc gtcgacgggc agttctacgc taccgcggac
    27121 atgtgcacgc acgaggagtg gtcgctgggt gaggaaggcg aactgtgcgg tttcgaggtc
    27181 acctgcacgc tgcacaacgc gaagttcgac attcgcgacg gaacggcgtt gtgcttcccc
    27241 gccacggtcg ccctgcgccg ctaccccacg accgtggagg ccgggaaggt ctacgtgctg
    27301 accgaggagt ccgctggtga ggactgagcg gttcaccggc cgcgtcgccg tcgtcaccgg
    27361 tggcgccagc cccatcggtt tcgggatcgc ggcacgactg gccgacgagg gcgccacact
    27421 cgtgctgggc gatgtcgata cggaccggtt gcggaccgcg gcggccgagc tggcatcgga
    27481 cccaccgggc cgagtccgga ccgtctccgg ggatctcagc gaacgcgcgg acgccgaacg
    27541 gctgatcgcg accgccgcgg aaacggccgg acgcctggac attctggtca actgcgccgg
    27601 cggcggcgtg atcctgccga cccccgaaca caccgaagac acggtgcgag cgacgatcga
    27661 ccggaacctc tggacgacgc tgcactgcac gctggcagtg ctgccgatca tgtccggggc
    27721 cgggtacgga aggatcgtca acatcggtgc ggaatcggtg cgcaacggcc tctaccggca
    27781 cgcggtgtac aacgccgcga agggcggggt gcacgcgttc gccaccggcc tcgcacgcga
    27841 gtacgccgag cggggtatca cggtgaacac cgtcgcgccg gcgtggatca gcactccgga
    27901 ggcggatgcc cggatcgtgg ccgcccccga ggcggaacgt cgcgacatgg cggagttttt
    27961 cgcgcagatc aggtccacga tcccgatggg ccgtccgggg acggtggccg aggtcgccgc
    28021 ggcggtcgcg ttcgtcgccg cggaagaggc gtcctacgtg accgggcaga cgatcagcgt
    28081 caacggcggc agctccatgc tttgatcccg tcctcggagg agcgggcctg cccagccggc
    28141 tcgctcctcc ggcctcgctg gtctcaggcg agggtcgggc ggtatgtgta ggacgtgctg
    28201 cggctgagcg cgaattcgaa gatccccgtg ccgcgaaccc cgttccagcg gtaggacgcc
    28261 agccggtcgg tcaacggcga gtcgagggtc cgctggtgga ccgacccatc cagcgggtag
    28321 gtgtcgtgct ccaggtggtc ccgacccatc cggcgcccgt ggtgcccgcc gtacccgcca
    28381 cccgccatga agccgccacc ggccgtggcg tccacgtcga tcagatatgt cgtgccgcgc
    28441 ttggtcacca cttccacggt gccgtcccgc aggtcgagcc cgtcgaagcg gaggtcgtgc
    28501 cggacgtcga cgacggcgtc gaggacgccg tgctcgtgca gcaccgcacc ttccagcagc
    28561 agtcgtccgc cgccgcggtc ctcgaccagc aggaggctga ccgagcggtc cgggaactgc
    28621 gcctggaacc acgcgtgcat cccctggcct cccg
//
