LOCUS       NZ_JADDUE010000020     24589 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Saccharopolyspora sp. HNM0986
            NODE_20_length_45768_cov_77.795145_cov_77.795145, whole genome
            shotgun sequence.
ACCESSION   NZ_JADDUE010000020
VERSION     NZ_JADDUE010000020.1
KEYWORDS    WGS; RefSeq.
SOURCE      Saccharopolyspora sp. HNM0986
  ORGANISM  Saccharopolyspora sp. HNM0986
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (bases 1 to 45768)
  AUTHORS   Li,F.
  TITLE     Diversity and distribution of actinomycetes associated with coral in
            the coast of Hainan
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 45768)
  AUTHORS   Li,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2020) chool of Life and Pharmaceutical Sciences,
            Hainan University, 58 Renmin Avenue, Meilan District, Haikou, Hainan
            570208, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 232.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016526145.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 02:15:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,899
            CDSs (total)                      :: 5,838
            Genes (coding)                    :: 5,784
            CDSs (with protein)               :: 5,784
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 7 of 54
            Pseudo Genes (incomplete)         :: 49 of 54
            Pseudo Genes (internal stop)      :: 0 of 54
            Pseudo Genes (multiple problems)  :: 2 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:09:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 16304
            Orig. end                         :: 40893
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADDUE010000020.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24589
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24589
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24589
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14589](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14589)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            128..430
                     /locus_tag="INP57_RS28415"
                     /old_locus_tag="INP57_28430"
     CDS             128..430
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010693663.1"
                     /locus_tag="INP57_RS28415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28430"
                     /product="hypothetical protein"
                     /protein_id="WP_200073451.1"
                     /transl_table=11
                     /translation="MATGHITANYVPDGDDWSVTVSADGNTRTARAPGLIAARDQADQI
                     IEHLAPNSSGRVVIHLLNGDGFAFSTAYLQARHGLSDEATRQAAAAADASSNAPR"
     gene            467..1078
                     /locus_tag="INP57_RS28420"
                     /old_locus_tag="INP57_28435"
     CDS             467..1078
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010693665.1"
                     /locus_tag="INP57_RS28420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28435"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_200073452.1"
                     /transl_table=11
                     /translation="MDAVNAPTSSPPGRGRPRDATRDAALRTAAMEVLAEVGYRALTMD
                     AVAARARAGKATIYRRWESKLDLVIDTCTELVQRNIPEPDTGSVAGDLGEFLRAFATFL
                     TGPAGKAAQALVGELPHESELAAAFRESFLLPQRNVLRLIMERGTERGEIAPDAPVDTV
                     VELAGAGLLHRLMLTGEPLDTRFVDRLLGEALLPLLRKQR"
     gene            1129..1860
                     /locus_tag="INP57_RS28425"
                     /old_locus_tag="INP57_28440"
     CDS             1129..1860
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030151 - molybdenum ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420472.1"
                     /locus_tag="INP57_RS28425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28440"
                     /product="MOSC domain-containing protein"
                     /protein_id="WP_200073453.1"
                     /transl_table=11
                     /translation="MSRGNVAQLHRWPVKSLRGEAVGAARFADGGMVGDRAHVLRDERE
                     KRSGAVLTVRQNPALLHWSSDYGAAADPALPPTLHDGAGTHWKWDDPELPAALTESLGI
                     PLSLHSAAGNQDRGPTVLVTLQSTLDALTAEMGDEVDLLRFRPNVHLDADIAPFGELDW
                     EPGTTVTAGEVTLEITGERAGACVRCAVPSWDARGRTRWKALQTRLIDEHDNKFGTIMR
                     VVRGGTVHRGAEVAVMRPEGR"
     gene            complement(1885..2106)
                     /locus_tag="INP57_RS28430"
                     /old_locus_tag="INP57_28445"
     CDS             complement(1885..2106)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945408.1"
                     /locus_tag="INP57_RS28430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28445"
                     /product="DUF3618 domain-containing protein"
                     /protein_id="WP_200073454.1"
                     /transl_table=11
                     /translation="MARDPDAIQREIEKTRDALAETLDELSTKADPKRFVEQGKAGVQE
                     RLNDPRVRYVAIGVGALVAVIVVRKIFR"
     tRNA            2278..2351
                     /anticodon=(pos:18616..18618,aa:Leu,seq:tag)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="INP57_RS28435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="INP57_28450"
                     /product="tRNA-Leu"
     gene            2278..2351
                     /locus_tag="INP57_RS28435"
                     /old_locus_tag="INP57_28450"
     gene            complement(2778..3152)
                     /locus_tag="INP57_RS28440"
                     /old_locus_tag="INP57_28455"
     CDS             complement(2778..3152)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013674211.1"
                     /locus_tag="INP57_RS28440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28455"
                     /product="hypothetical protein"
                     /protein_id="WP_200073455.1"
                     /transl_table=11
                     /translation="MDPFASSAPVLVTIGDIACTQDEVITPSGRAPIVGTTWTFTDMSR
                     TNSGIPAWAIVCAVIFFLFCFLGLLFLLAKEERTDGSVQVTVQGPGLLHTVQIPVFAQA
                     AAMDFNARVNYARSLAHQPF"
     misc_feature    complement(3324..3338)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.82"
                     /tool="antismash"
     gene            3398..4051
                     /locus_tag="INP57_RS28445"
                     /old_locus_tag="INP57_28460"
     CDS             3398..4051
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF016550.5"
                     /locus_tag="INP57_RS28445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28460"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_255520986.1"
                     /transl_table=11
                     /translation="MDDPERTPGSEPSSLPPEVDTSVPSVARIYDYAVGGKDNFRVDRD
                     ATYAMLQGVPDIITTARDNRAFLGRGVRYLAREAGIRQFIDFGSGLPTQLNVHQVAQQE
                     NSGGHVVYVDNDPVVLAHGRALLTDDQRTTVIQADMARPAAVLEHDDTRRLIDFAHEPV
                     AVLYVSVLHCLPDEAEPRQAVATMLDAVPSGSYLMMSRTWSATTPTPRNSSPGS"
     gene            4048..4275
                     /locus_tag="INP57_RS30170"
     CDS             4048..4275
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016550.5"
                     /locus_tag="INP57_RS30170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_255520987.1"
                     /transl_table=11
                     /translation="MNEQTTWGRVRTEAEVTALFDGLEVVDPGLVNITRWRPSEQEPAM
                     HTDALFDYEIPARPELENKIWEFGGIARKP"
     gene            4407..5165
                     /locus_tag="INP57_RS28450"
                     /old_locus_tag="INP57_28465"
     CDS             4407..5165
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.5"
                     /locus_tag="INP57_RS28450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28465"
                     /product="ABC transporter permease"
                     /protein_id="WP_200073456.1"
                     /transl_table=11
                     /translation="MSIGTAQRTTAGFGTVVATELYRARHGPLLWLMLLSPVALALPML
                     LATALGGDWEQWQGLALMGWGGLLPAVTALAVGLDVRQDRDAWLFLLAAPVSRNHLVLG
                     KAAALVVVTALGSLVLGIALCAGALLAGLALPTGPLTGVLAMWVALFGIAGLLLLLAIS
                     FGFPVTVGAGVVGVFAGLLTADKAFWFVNPFGWPLRAMLPFGRRLVGVEIPDSSPLAAT
                     GPVLTAMLLSLALAAATTAAACVVLRRKEI"
     gene            5244..5999
                     /locus_tag="INP57_RS28455"
                     /old_locus_tag="INP57_28470"
     CDS             5244..5999
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.5"
                     /locus_tag="INP57_RS28455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28470"
                     /product="ABC transporter permease"
                     /protein_id="WP_200073457.1"
                     /transl_table=11
                     /translation="MSIAARNTAGLGTIIGTELYRARRGSLVWLMSLTPLVIALPMVVS
                     TALGADWPEYRGMTLTGWGSLLPAFIALLVGIAVTQDREAWLFLLAAPVARNGLVLAKM
                     ASLAVITAVPSLILGLALWIGGINSGVPVPADALAGAAAMWVALLGIAGLMLLLTLAAG
                     MATTIAVGVVGALAGMLTADKAFWFLNPFGWPLRAMLPFGQVRANGVALPPGSPLADLG
                     PAFAAMLLSVVLAAAATALSCMVLRRKEI"
     gene            5999..6703
                     /locus_tag="INP57_RS28460"
                     /old_locus_tag="INP57_28475"
     CDS             5999..6703
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="INP57_RS28460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28475"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_200073458.1"
                     /transl_table=11
                     /translation="MSTALAADDIVKSYRSTPVLRGVSLDVPTGSVTGLIGPNGAGKTT
                     LLSIIGGLRRQDSGNVSVWGRPRQAETLHDVGFLLDHPGLWPFLTGRGNLLVHARLRGV
                     PESRVDTVLRQVDMAEHADRKVGKYSLGMRWRLGIAIALVGDPRVLVLDEPTNGLDPVG
                     IRDMRALLRSLADEGRAVLISSHQLYEVAQICDRISVLVSGTMRYQGPLHGLADDNDLE
                     AAFFRLIDGAAK"
     gene            complement(6744..7298)
                     /locus_tag="INP57_RS28465"
                     /old_locus_tag="INP57_28480"
     CDS             complement(6744..7298)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS28465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_28480"
                     /product="hypothetical protein"
                     /protein_id="WP_200073459.1"
                     /transl_table=11
                     /translation="MADHRARLLDRLSALRTSLHSAEGREPALGRRLADVALRRCPQDP
                     EQVLPIPANGAVELDWSSMLHTGDEYFADQVTGIALSSELAGELRERVVLALEARLVNA
                     ARAQDSHSLAVLLRAALVAGAGETATIRQGIGLLVTAPPPAATDADGAAATVQHVWALA
                     EAWRPGTTGSALRPRGARPRG"
     gene            complement(7291..8214)
                     /locus_tag="INP57_RS28470"
                     /old_locus_tag="INP57_28485"
     CDS             complement(7291..8214)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF046440.1"
                     /locus_tag="INP57_RS28470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28485"
                     /product="hypothetical protein"
                     /protein_id="WP_200073460.1"
                     /transl_table=11
                     /translation="MTGSAERVAEHGLRWLENNLEWFEPARWERFLPPRRFRAAPLLEL
                     LILVRLLRGGPHAERAERIGTAAHRVAEAVCAETGFHDELSRGGPAFAYHAHLVALLTD
                     AGRAPARARSLVQAVLDTGTGELFAADRPALNRLELRYVLDLGGFDRSGYRTDQSHRNS
                     VLTTRQGPLSFADDEVYALTHVLFYLSDFGSRPVSGSDLADREKAGRTVSVLLGACLAR
                     DDLDLAGELLLCADILGVHCRGLVEHGWQRIASAQRADGAVPSPLHDSAVLSKVDGDKR
                     AAYLFGTCFHTTMVAVMAASGRASRG"
     gene            complement(8222..9046)
                     /locus_tag="INP57_RS28475"
                     /old_locus_tag="INP57_28490"
     CDS             complement(8222..9046)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.5"
                     /locus_tag="INP57_RS28475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28490"
                     /product="ABC transporter permease"
                     /protein_id="WP_200073461.1"
                     /transl_table=11
                     /translation="MTNLLERPSGSSGLGERAAVGAFRSIGVIAQRDLIRQLRNPGMLA
                     TQAMQMVFVVVVFGVGFNSMIAPDGGLPFSAYVFPGVIAIQIVTVAINSGLGYAWDREF
                     GVLREMQVAPTPKVCLPAGKMVATGIIVCVQSAIMLLLSPLLSVPLTLRGFLGATLAYT
                     VAGMVFSAIGLFLATAIRRVQTLQSSVALLMFPMLFLSGAVFRPDQLPSWLTAVVGVNP
                     MSYAVDLVRHVLLNAAGEQVPGGGQANPLFDLVLLLAFGAVAGVAVRLRVGR"
     gene            complement(9030..10028)
                     /locus_tag="INP57_RS28480"
                     /old_locus_tag="INP57_28495"
     CDS             complement(9030..10028)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="INP57_RS28480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28495"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_200073462.1"
                     /transl_table=11
                     /translation="MAVVPRTAVMDRTGADAGPVAALEIDRLVVRYPSVLAVDEFSYSS
                     PAGQVTALLGPNGAGKSSVLGAVSTAVPCESGTIRIFGRDIRHDAVAARAQLGLVFQER
                     TLDKDLSVYRNLWFHARLFGMRSKESRQRIDAVLDRFGLADRRSDAVRNLSGGLARRVE
                     VARSLLHGPGLLVLDEPTNGLDPEARAKVWDDLRRMRDELGVSILFSTHYMDEAEVADE
                     IVIISDGRLVRRGSADQLKLGLARSSVLLRTQDDAVASANLVAAGWRVSPDSGALRVDC
                     AEPEKSIAEIVGCAGTGVVEVRAVHPTMDDVYLSATRSGGAGPGGGDDELA"
     gene            complement(10001..11404)
                     /locus_tag="INP57_RS28485"
                     /old_locus_tag="INP57_28500"
     CDS             complement(10001..11404)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="INP57_RS28485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28500"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_200073463.1"
                     /sec_met_domain="LANC_like (E-value: 8.3e-57, bitscore:
                     184.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVRTESAAPIAAADRDRVDEAVAVVADKLADPDRVAAVAGRDDN
                     RDPIYGNVMWAPVTLSNGWPGVAAFYGELARRDTRWRATAHEHLSRAAEALPSTPHRGL
                     FAGPAALLAAAQAAAAGSGHYARMRAKLAGRLAELVLAQVDHLRAQQGAGVDWSGYDLI
                     NGVSGSVRVLLESARDPAESGSRVREALDAGLRHLVRCTEPIHVRGHEVPGWWVPPEAQ
                     PTDRDRADYPEGDFNLGLAHGAPGPLAVLSRAASYGYEVPGHRAAITRTVEWLLHWKLT
                     DDAGPYWPCRIGLAQQIAGPSELTRPITRTAWCYGAPGVAIGLHAAGTALDRPEWTAEA
                     VSALQAALRRDEAEWAVDGPTICHGYAGLLAICTRVGVDTGSAELLAGTARLVRSVLEL
                     GDDRAEFHFPHLMRYPGGQRSDGRTHKAVDVAGLLEGAAGVAAALHAAAHPDDDEGGAP
                     VWQWCLGLR"
     gene            complement(11401..14589)
                     /locus_tag="INP57_RS28490"
                     /old_locus_tag="INP57_28505"
     CDS             complement(11401..14589)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="INP57_RS28490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28505"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_200073464.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.5e-175,
                     bitscore: 576.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.3e-15,
                     bitscore: 49.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.6e-37, bitscore:
                     119.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDPAHAQPLREDLFAAWDFYLLRAPLGATRPQLTGAETDAGAQA
                     ACSRLLRRAVEDEHLMEALALASPSLRGLLLRVAAGDGGAVKPAQLRRAAFAVLRYDLR
                     MRTRPTPFGLFAGVACGDFEADVDAGRLPRTPARGSQRTRTQVDMQWLLGVVQELETRA
                     VEMPALRVHAHPALVVRGDRVVLDCASTFGAVPGRNSRARVSVRYSAPVRRALELGAEP
                     VRLGQLTERLVAEFGERARERVRGLLSSLIAEEVLLTELRPALDGSDPLTRLCEVLDAA
                     NAAPVAQRHLELRELADRIAAYDRIPAGSGAAALADTVADAQRIHQHPTPLHVDARLAG
                     STALPAAVAAEVAGAAELMWRTSTPKIGLHALRDYHAQFLERYGTDRLVPLLDLLDGNV
                     GLGPPAGYSWPNSDVPDARTEAEPDRDRDRLLHRLLADALRSGDREVVVDASTMRALCR
                     GAAEPAQVPNSCEVTVQVAAPSAERLLDGEFLVSLSPSPGSHHAGSTFMRFAGALDADH
                     ERRLHEESSALPTHVAGALRADLAFLPRSGKAANLAHTAPDTGHRIGVGVFDSPSAAEI
                     RLGDIGVGATLERLCAVHLPTGRELTPVLANMVSAPAQAPNAARLLWEIGLEGQRLWEP
                     WKWGRLADSPFVPRIRFGRFVLAPAVWRLDDVREAAAGRDPAEAVARWRARYDVPRHVL
                     IVSNDQRLGLDLDDPWHVELLLEEVRKDPDLVVHEVAGEHEGWLHGELAGHVGEVVVPL
                     RRRDPEPRRAATPAYREPRERAHGPGGEWLYLKLYGTARGQDDLLRNRFGALVDTAREL
                     GADRWFFLRYTDPDGHHLRLRLHGEPHRLWSDVVPELGRTLLDWQQEGLLRTHRIDQYD
                     PEHERYGGIRLAPAVERLFQADSAAAIELLSLAADPECPYDLDTLAAISVAALAEAFGP
                     PGTDPGAGAAEFWLGRTGTRRDLPKRYRRSPAYWAGLVDPAGGSTGLAAAVFGAKVLGH
                     LRGRDELVTSVRAEMDRQRVDGDCRIGEGRFLGSLLHMHCNRLFGGDSAREREVIALAR
                     GAVQDNANRRRFTG"
     aSDomain        complement(13798..14073)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_INP57_RS28490_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="7.80E-16"
                     /identifier="RREFam001.1"
                     /label="INP57_RS28490"
                     /locus_tag="INP57_RS28490"
                     /protein_end="264"
                     /protein_start="172"
                     /score="49.5"
                     /tool="antismash"
                     /translation="AHPALVVRGDRVVLDCASTFGAVPGRNSRARVSVRYSAPVRRALE
                     LGAEPVRLGQLTERLVAEFGERARERVRGLLSSLIAEEVLLTELRPA"
     gene            complement(14657..14830)
                     /locus_tag="INP57_RS28495"
                     /old_locus_tag="INP57_28510"
     CDS             complement(14657..14830)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="INP57_RS28495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28510"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_200073465.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.9e-11, bitscore:
                     35.5, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAATDQAVAEAEVDLFDLDLEVGFEATMANPAVTSVSYCTPGCT
                     SEGGGSNCSHCC"
     CDS_motif       complement(14732..14830)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSAATDQAVAEAEVDLFDLDLEVGFEATMANPA"
                     /locus_tag="INP57_RS28495_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14657..14731)
                     /prepeptide="core"
                     /locus_tag="INP57_RS28495_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="6.50"
                     /molecular_weight="2195.4"
                     /monoisotopic_mass="2193.8"
                     /core_sequence="VTSVSYCTPGCTSEGGGSNCSHCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSAATDQAVAEAEVDLFDLDLEVGFEATMANPA"
                     /leader_location="[14731:14830](-)"
                     /alternative_weights="2213.4"
                     /alternative_weights="2231.4"
                     /alternative_weights="2249.4"
     misc_feature    15069..15084
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.34"
                     /tool="antismash"
     gene            15140..15721
                     /locus_tag="INP57_RS28500"
                     /old_locus_tag="INP57_28515"
     CDS             15140..15721
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="INP57_RS28500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28515"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_200073466.1"
                     /transl_table=11
                     /translation="MTEAGTHSAGLLARVAEGDEEALGLLYREHAGSMLRLIGRLTTNR
                     AEAEEILQEAWLAVWQSAAAFRGDSAPRAWLLGVARRQAHNRLRRAALSTAELDAAAQV
                     PQAGPDVEDRVLAGMEFEQVLARVRDLPRHLREVLDLVLVEQLSYREIAGVLDVPVGTV
                     KSRMSHIKRELAQGTHWESSHRPPQEGSRR"
     gene            15718..16656
                     /locus_tag="INP57_RS28505"
                     /old_locus_tag="INP57_28520"
     CDS             15718..16656
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS28505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_28520"
                     /product="hypothetical protein"
                     /protein_id="WP_200073467.1"
                     /transl_table=11
                     /translation="MSHLDADEVLEAARQQAAGGRVRSADHLRECARCADGVAAMARLT
                     AAGEVLAAEEDRELAVPSFEHVRAALPGNQARTGPQREPAPRGAPERRGKQLLRLTAAL
                     VWAQLALLPRLLLPASAFAFAAAVVLATALPESSAGLREHAFGAAVVLIVLAGALTTYS
                     GGRDPRTELQFSLPIAPPTVFVCRVVGVLGLDVLLAVLGSVAVHVFGGSPSLAGVLASW
                     FGQALLTVGVALVFAVAHAPATGTLAGVLVWLLGSSSGLPEAGGLGGILRPAVSTLWTS
                     SPAVVALALALLAIAVLGMRFPRFGPRREGS"
     gene            16660..17301
                     /locus_tag="INP57_RS28510"
                     /old_locus_tag="INP57_28525"
     CDS             16660..17301
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS28510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_28525"
                     /product="hypothetical protein"
                     /protein_id="WP_200073468.1"
                     /transl_table=11
                     /translation="MAVNRIERRRYVPGMRSLSRYEMRRCGPAVLAVPPLAGITVGIAS
                     SLAGWQSLLLGEVLPVLVALPAAAVADGDPLRELHETLPRRYVRTAACRLGIAAGAVLT
                     GVVAAAVLCAAFGGGASVLGHAAAALCSAVLLVGIGALVGAASSSAAAASTAMIAVWLG
                     QLLLGDRILGDGAARLLVPACVGCAALALALRRFDSGADVLGAARSGAGS"
     gene            17298..18137
                     /locus_tag="INP57_RS28515"
                     /old_locus_tag="INP57_28530"
     CDS             17298..18137
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS28515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_28530"
                     /product="hypothetical protein"
                     /protein_id="WP_200073469.1"
                     /transl_table=11
                     /translation="MTAPGVRTVLATARYEALIALRTKALWWSLLPLTALALLLAATSG
                     RVVGASDPVRRVAETSLVFSLLCTLGIAVGLAGRLAGHRRSGLTDLLDATAAGIPARVA
                     GSLLGSLLVALVPPVCGFLLLVVVTSISTGAPAAVGAGLLAIVVVLLPASLMLSSFAAM
                     LGVLLPVAAARVLTAVFWLWATVLNPMLLPVPTATGTVLSPLARYPAAAWLHASPASAT
                     YGLSGALRPEVHSATATAQVLCTLAASAVFLAVAAIRLNARTRVPNRRARWMSRSAQ"
     gene            18113..18994
                     /locus_tag="INP57_RS28520"
                     /old_locus_tag="INP57_28535"
     CDS             18113..18994
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="INP57_RS28520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28535"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_200073470.1"
                     /transl_table=11
                     /translation="MDVSLSAVTKVYRGGARVLDGLDLEIGEGMLGLLGANGAGKTTLM
                     RLLTTVLKPTSGRIAVGGHDLSTRSGVHAVKRMLGYLPQELSLYPELTGAEFLDYVALL
                     KGIGDRAERRRQTDDLLEQVGMRQHAKQRIGDYSGGMKRRIGIAQALLGDPELLVVDEP
                     TAGLDPQERMRFRALLAGLSGVRIVILSTHILDDVAQSCPNVAVLGDGKVAYHGSTAGL
                     TSAASGRTYLVPPGRPVPPDSTVVNAVAGPEGTEYRVISENPVPGARQVEPSLEDGYAA
                     LVRNSSDKMAVN"
     gene            18994..19371
                     /locus_tag="INP57_RS28525"
                     /old_locus_tag="INP57_28540"
     CDS             18994..19371
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS28525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_28540"
                     /product="hypothetical protein"
                     /protein_id="WP_200073471.1"
                     /transl_table=11
                     /translation="MRTLTKLVLLGSAALALTGCGGGGQGTAEAGAPVPMPPARNGEQP
                     ISAANMGHLWPLTVPGGVLTCVGDNEAVFTDPGGRSYALNERAERHHPSIEPLRAQGEG
                     SEKISLGALRSKTLKLCPEQR"
     gene            complement(19400..20020)
                     /locus_tag="INP57_RS28530"
                     /old_locus_tag="INP57_28545"
     CDS             complement(19400..20020)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS28530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_28545"
                     /product="response regulator transcription factor"
                     /protein_id="WP_200073472.1"
                     /transl_table=11
                     /translation="MHAHLKALVSGMVGTLPLPEFGFAVEFFEASGVEALADNGNPVFL
                     PATSEDQAACISNLRDCGHWLSPVVAVVHDYNGHQTYSAIKHGASSVLNLAIPVGAQLE
                     AVRATAINAGNSRADADTRVSNALMAPYERAAGFAGEPTMDDEELDRLKNMLCSEETVS
                     AIARRFFCSERTLYRRIRMLYDKLQVSSRAELRSLLATSRRAG"
     misc_feature    complement(20137..20152)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.53"
                     /tool="antismash"
     misc_feature    20248..20263
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.77"
                     /tool="antismash"
     misc_feature    20248..20264
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.62"
                     /tool="antismash"
     gene            20523..21674
                     /locus_tag="INP57_RS28535"
                     /old_locus_tag="INP57_28550"
     CDS             20523..21674
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037650.5"
                     /locus_tag="INP57_RS28535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28550"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_200073473.1"
                     /transl_table=11
                     /translation="MDFATARTLVRAATLGIDDLERAIAAAGACPAVDFLLDEIRPRLR
                     LSELSEFDQDTIVRLCLQAGAETVHRDLVVRRNGSGWAFGPSGEHPVAAAAVITQDLAE
                     ALRGTVSPSGASAATRSVQWRDADDFTAFHSPPAAFRVVQRLLAAMERRDDRDLSALAA
                     HHGSDKWGLHNYTPHYQRHFEPLRDEPIVLLEIGVGGYQDPTGGGASLRMWRDFFPRAL
                     VYGLDVVDKSAHDEGRIRTLLADQADPGSLSRAVEPIGRPDIIIDDGSHINKHVLSTFR
                     ALFPLLRPGGKYVIEDLQTAYWPSFGGSEQSTCDPHTTIGLLKDLVDGLNHQELTERNP
                     RSSSTTDTQIAGVHFHHNLAVLDKGLNLEPGAPSWLARTQPES"
     gene            21674..22720
                     /locus_tag="INP57_RS28540"
                     /old_locus_tag="INP57_28555"
     CDS             21674..22720
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF025025.5"
                     /locus_tag="INP57_RS28540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28555"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_200073474.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 4.3e-29,
                     bitscore: 93.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAARIAVICPAFNRSAAILPTVESVLAQTVQDWELLVVSDGSTDD
                     TDEVVRAVRDPRVRLLRVANHGCPGGPRNAGLAATSAPYVAYLDHDDVWLPNHLEVLLG
                     MLQAGAPLAGTGCVRVGPSGRVRHRSGVLDSVWHPELQVLNAMYEPSRVGHVRPLVAEA
                     GGWSTAAAGFEDWDLWTRLAERGVDFAVAADRTSVLTLEDGSRRHLFSPRHSIGLAKTG
                     AERDADRVRDLLAGEHGRARAEAAYLADTEAWYVDLWDSARCVRPPEVRRVDVLEAVRA
                     KLASGEAGSFLHGLVTVPHAGGFVLALPTAVLNPQHRGRIRELLARRCPAQLRLLRELR
                     AQASTGAL"
     gene            22907..23218
                     /locus_tag="INP57_RS28545"
                     /old_locus_tag="INP57_28560"
     CDS             22907..23218
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS28545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_28560"
                     /product="hypothetical protein"
                     /protein_id="WP_200073475.1"
                     /transl_table=11
                     /translation="MTALRRMFIAGVTACALGGLVVPTAVAATGTAQPAPATEIGVRKT
                     WHATVQCHIVRISDNHVIGYDRADGVGNTKDKAITDAERNVPVPQGHYKRHCDPKRIW"
     gene            23266..23487
                     /locus_tag="INP57_RS28550"
                     /old_locus_tag="INP57_28565"
     CDS             23266..23487
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101467.1"
                     /locus_tag="INP57_RS28550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_28565"
                     /product="hypothetical protein"
                     /protein_id="WP_200073476.1"
                     /transl_table=11
                     /translation="MSEESGIWEIRLGIYATEQQAEEVKERITRLLCPDPDHAPPCPIP
                     WSVRLMPEDADSYPALAEQARIEGHDQG"
     misc_feature    23863..23876
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.28"
                     /tool="antismash"
     misc_feature    complement(24098..24113)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.94"
                     /tool="antismash"
ORIGIN
        1 cgtagagtcg gcggtcacgc tgaggtgact cggcggccac ggccgaggcc gcgacgcccg
       61 caaggcaggc gcgccacccg gccgatgcgc ggagtcaccg tccgcaaccg cgcgacgggg
      121 aggcaacatg gcaacgggac acataaccgc caactacgtg ccggacggcg acgactggtc
      181 cgtcaccgtc tcggccgacg gcaacacccg aaccgcacgc gcacccggtc tcatcgcagc
      241 cagggaccag gccgaccaga tcatcgagca cctcgccccg aactccagcg gccgcgtggt
      301 gatccacctg ctcaacggcg acggattcgc gttcagcacg gcctacctgc aggcccggca
      361 cggcctctcg gacgaggcga cgcggcaggc cgcggccgcc gccgacgcct ccagcaacgc
      421 gccgcggtga tccgatgcgc gcacgcagcc cgtcgccctc tctaggatgg atgccgtgaa
      481 cgcaccgacc agcagcccgc ccgggcgcgg gcgcccccgg gacgcgaccc gggacgcagc
      541 cctgcgcacc gccgccatgg aggtgctggc cgaagtcggc taccgcgcgc tgaccatgga
      601 cgcggtggcc gcgcgggcgc gcgcgggcaa agccaccatc taccgccgct gggaatccaa
      661 gctcgacctg gtcatcgaca cctgcaccga gctggtgcag cgcaacatcc ccgaaccgga
      721 caccggcagc gtcgcgggcg acctcggcga attcctgcgc gccttcgcca cgttcctgac
      781 cggcccggcg ggcaaggccg cccaggcgct ggtcggcgaa ctgccgcacg agagcgaact
      841 cgccgccgcg ttccgcgagt cgttcctgct cccgcagcgc aacgtgctgc ggctgatcat
      901 ggaacggggc acggagcgcg gcgagatcgc cccggacgcc ccggtcgaca cggtcgtcga
      961 actggccgga gcgggtctgt tgcaccgcct gatgctcacc ggcgaaccac tggacacgcg
     1021 tttcgtggac cggctgctcg gcgaggccct gctccccttg ttgcgcaagc agcgctgaac
     1081 cgcgcacggg cgaaccgcta acctcgcgaa cgagctgagg aggtcggttt gtcgcgaggg
     1141 aacgtggcgc agctgcaccg ctggccggtg aagtcactgc gcggagaagc cgtcggcgcg
     1201 gcgcggttcg cggacggcgg gatggtcggc gaccgggcgc acgtgctgcg cgacgagcgg
     1261 gagaagcgat cgggcgcggt gctgaccgtg cggcagaacc ccgcgctgct gcactggagc
     1321 agcgactacg gcgcggccgc cgacccggcg ctgccgccga cgctgcacga cggagcgggc
     1381 acccactgga agtgggacga ccccgaactg cccgcggcgc tgaccgaatc cctcggcatc
     1441 ccgctgagcc tgcacagcgc cgcgggcaac caggaccgcg gcccgaccgt gctggtcacg
     1501 ctgcagtcca cgctggacgc gctcaccgcg gaaatgggcg acgaagtgga tctgctgcgg
     1561 ttccggccga acgtgcacct ggacgcggac atcgcaccgt tcggcgaact cgactgggaa
     1621 cccggcacca ccgtcaccgc gggcgaagtg accttggaga tcaccgggga acgcgccgga
     1681 gcgtgcgtgc gctgcgcagt gcccagctgg gacgcgcgcg gacgaacgcg ctggaaagcg
     1741 ctgcaaaccc ggctgatcga cgaacacgac aacaagttcg gcaccatcat gcgcgtggtg
     1801 cgcggcggaa ccgtgcaccg cggagccgaa gtcgcggtca tgcgcccgga gggccggtga
     1861 cccgccgggc gcaccccgcg gcaatcaccg gaagatcttg cgcaccacga tgacggcgac
     1921 caacgcaccg acaccgatcg cgacgtaccg caccctcggg tcgttcagcc gctcctgcac
     1981 gccggccttg ccctgttcga cgaaccgctt cggatccgcc ttcgtgctca actcgtccag
     2041 cgtctcagcc agcgcgtcac gagtcttctc gatttcgcgc tggatcgcgt cgggatcacg
     2101 ggccacgcgg tcctcctcca agtacaccct gctgcggaca ccgtagatca cacgcccgca
     2161 gcgcacccag cgaccgttcc cagtgtcccg accgcctccc ggcaccgccg gagaacagcc
     2221 gaaccgcccg gtcggggaca caacggacat caccacccgt taagctggca ccccatcggg
     2281 gccgtagccc aataggcaga ggcactaggt ttaggtccta ggcagtgtga gttcgactct
     2341 catcggcccc acgaggcggc ggatgctgct caccgccgct gcggattcgc cgtggcccgt
     2401 tgtattagtt gcgggggccg agcccccgca ggccccacgg tgcggtggtt gcgctgggtc
     2461 ggctccgcac cggctggtca cgaaccagcc gatcaacgaa cccaaaacca cgacacgctt
     2521 tgagcgcaaa gcggcggatg ctgctcaccg cgtcgggagg gtgttcgcgg tgtgcagcgg
     2581 cggccacact catttgcgaa cggcgaaaac gtcctggggc gacgtcgggt gacaggcgga
     2641 tcgcgcccga cctgaaggaa gttcgtggcc gaatcccgcg cggcggggcg gtgagcacgt
     2701 ccgggcagcg cttcccggga gctgatcgtc ctcgcggcga tccgagtgca gcgccggctc
     2761 tcgacgcggg cggtggctca gaagggctgg tgggccaggg agcgggcgta gttgacgcgg
     2821 gcgttgaagt ccatggcggc cgcttgggcg aacaccggga tctgcaccgt gtgcagcaga
     2881 cccggacctt gcacggtcac ctggaccgaa ccatcggtgc gctcttcctt cgccagcagg
     2941 aacagcagtc cgaggaagca gaacaggaag aagatcaccg cgcacacgat ggcccacgcg
     3001 ggaatcccgc tgttggtccg ggacatgtcg gtgaaggtcc acgtcgtgcc gacgatcggc
     3061 gcgcggccgg acggggtgat cacctcgtcc tgcgtgcaag cgatgtcccc gatggtgacc
     3121 aggaccggag ctgaactggc gaacggatcc acggacgcga gagtacaagt cgacgccgcc
     3181 ccgcgtgggc attttcggat cgaaccgggg atgtcccggc ggagaaaccc gcacgaaaac
     3241 gttgcggcgg cgcggaaaac tcagcaatgg ttgcgaaatc aaccggacgg aggccgcgcg
     3301 aaaccctgtc agggatctcg gacatcgact aagatgatct tgacccccgg gagctgcgcc
     3361 cggacgcagc cgcaccgtca gatgggccga gatcagcatg gacgaccccg agcgcacccc
     3421 cggaagcgaa ccgtcgtcgc taccgcccga ggtggacacc tcggttccca gcgtggcccg
     3481 catctacgac tacgcggtcg gcggcaagga caacttccgc gtcgaccggg acgccacgta
     3541 cgcgatgctg caaggcgttc cggacatcat caccacggcg cgggacaacc gcgccttcct
     3601 cggccgcggc gtgcgatacc tggcgcgcga ggcgggaatc cggcagttca tcgatttcgg
     3661 cagcggcctg ccgacccagc tcaacgtgca ccaagtggcg cagcaggaga actccggcgg
     3721 gcacgtcgtt tacgtggaca acgaccccgt cgtgctcgcg cacgggcggg cgctgctcac
     3781 cgacgatcag cgcacgacgg tcatccaggc cgacatggcc cggcccgcgg cggtcctcga
     3841 gcacgacgac accaggcggc tcatcgattt cgcgcacgag ccggtggcgg tgctgtacgt
     3901 gtcggtgctg cactgcctgc ccgacgaagc cgagccgcgg caggcggtcg cgaccatgct
     3961 cgacgcggtg ccgtccggga gctacctgat gatgtctcgc acctggtcag cgacgacgcc
     4021 gacgccgcgg aattcctcac ccggttcatg aacgagcaga ccacgtgggg ccgggtccgc
     4081 accgaagccg aagtcaccgc cctgttcgac gggctcgagg tggttgatcc gggactggtc
     4141 aacatcaccc gctggcggcc cagcgagcaa gaaccggcca tgcacaccga cgccctgttc
     4201 gactacgaga tccccgcccg ccccgagctg gagaacaaga tctgggaatt cggcggcatc
     4261 gcccgcaagc cctgatgccc cacaagccct gatgccccgc aagccctgat gcgctgaccc
     4321 actcgctgcg gtcatcgcgg atcggtcgtg aaccagcggc gccgacgcgg ctacgtacct
     4381 tccgaacgac gaaggaagga cgtcgcatgt cgatcggcac cgcgcagcga accacggctg
     4441 gtttcggcac cgtcgtcgca accgagctct accgcgcgcg ccacgggcca ctgctgtggc
     4501 tgatgctgct cagccccgtc gcgctggcgc tgcccatgct gctcgcgacg gctctcggcg
     4561 gtgactggga gcagtggcag gggctggcgc tgatgggctg gggcggcctg ctgcccgccg
     4621 tcaccgcgct ggccgtcggg ctcgacgtgc gccaagaccg ggacgcgtgg cttttcctgc
     4681 tcgccgcgcc ggtttcgcgg aaccacctgg tgctgggcaa ggccgccgcg ctggtggtcg
     4741 tcaccgcgct cggcagcctc gtgctcggca tcgcgttgtg cgccggtgcg ctgctcgcgg
     4801 gcctcgcgtt gcccaccggg ccgctcaccg gagtgctcgc gatgtgggtg gcgctgttcg
     4861 ggatcgcggg cctgctgctg ctgctggcga tcagcttcgg tttcccggtc accgtcggcg
     4921 ccggagtcgt cggggtgttc gcggggctgc tcaccgcgga caaggcgttc tggttcgtca
     4981 atcccttcgg ctggccgctg cgcgccatgc tcccgttcgg caggcggctg gtgggcgtcg
     5041 agatcccgga cagcagcccg ctggccgcca cggggccggt tctcacggcg atgctgctgt
     5101 cgctcgcgct ggccgccgcg accaccgcag cggcctgcgt cgtcctgcgg cgcaaggaga
     5161 tctgaatgcc gtcgcagaac cggcgcggac ggccacccgc gcaatccacc cctaccggcc
     5221 gcagatcctc gggaggaacc gccatgtcca tcgctgcccg gaacaccgcc gggctcggca
     5281 ccatcatcgg caccgagctc taccgcgcac gccggggctc cctggtgtgg ctgatgtcgc
     5341 tgacgccgct ggtgatcgcg ctgcccatgg tcgtctcgac cgcgctcggc gccgattggc
     5401 ccgagtaccg cggtatgacg ctgaccggct ggggaagcct gcttcccgcg ttcatcgccc
     5461 tgctcgtcgg gatcgccgtc acccaggacc gggaggcctg gctgttcctg ctcgccgcac
     5521 cggtagcgcg caacggcctg gtgctcgcca agatggcctc gctggccgtg atcaccgcgg
     5581 tgcccagcct catcctcggc ctcgcgttgt ggatcggcgg aatcaacagc ggggtcccgg
     5641 ttcccgcgga cgcactggcg ggcgccgccg cgatgtgggt ggcactgctg gggatcgccg
     5701 ggctgatgct gctgctgacc ctcgcagccg ggatggcgac caccatcgcc gtcggcgtcg
     5761 tcggcgcgtt ggcggggatg ctgaccgcgg acaaggcctt ctggttcctc aaccccttcg
     5821 gctggccgct gcgcgcgatg ctcccgttcg gccaagtgcg ggcgaacggg gtcgcgctgc
     5881 caccggggag cccgctggcc gacctcgggc ccgcgttcgc cgcgatgctg ctgtcggtcg
     5941 tgctcgccgc cgctgccacc gcgctgtcct gcatggtcct acgacgcaag gagatctgat
     6001 gagcaccgca ctcgccgccg acgacatcgt gaagagctac cgcagcaccc ccgtgctccg
     6061 cggggtctcc ttggacgtcc ccaccggctc ggtcaccggc ctgatcggac ccaacggtgc
     6121 cgggaagacc acgctgctgt ccatcatcgg cggcctgcgc cgccaggaca gcgggaacgt
     6181 gtccgtctgg ggcaggccgc ggcaggccga gaccttgcac gacgtgggtt tcctgctcga
     6241 ccaccccggc ctgtggccgt tcctgaccgg ccgggggaac ctgctggtgc acgcacggct
     6301 gcgcggcgtc ccggagtcca gagtggacac agtgctccgc caggtggaca tggccgagca
     6361 cgccgaccgc aaggtcggca agtactcgct ggggatgcgc tggcggctgg gaatcgccat
     6421 cgcgctggtc ggcgatccgc gcgtgctggt gctggacgaa ccgacgaacg gtctcgaccc
     6481 ggtcggaatc cgggacatgc gggcgttgct gcgctcgctg gccgacgaag ggcgagccgt
     6541 gctgatctcc agccaccagc tctacgaagt ggcgcagatc tgcgaccgca tctcggtgct
     6601 ggtctccggc accatgcgct accagggtcc gctgcacggc ctggccgacg acaacgacct
     6661 ggaggcggcg ttcttccggc tgatcgacgg cgccgccaag tagggcgccg gggaagccgc
     6721 ccgccggtgc gggaagcggg atctcagccg cgggggcgcg caccgcgcgg gcggagcgcg
     6781 ctcccggtcg tgccgggccg ccaagcctcc gccagggccc acacgtgctg caccgtcgcc
     6841 gccgccccat ccgcatcggt tgcggcgggc ggcggtgcgg tgaccagcaa gccgatgcct
     6901 tgccggatcg ttgcggtctc gcccgccccg gccaccagcg ccgcccgcag cagcaccgcc
     6961 agcgagtgcg agtcctgcgc acgggccgcg ttcaccaacc gggcttccag cgcgagcacg
     7021 acccgttccc gcagctcgcc ggcgagttcg gagctcagcg cgattccggt cacctggtcc
     7081 gcgaagtact cgtcaccggt gtgcagcatc gaggaccagt cgagttcgac ggcaccgttc
     7141 gccgggatcg gcaggacctg ctcggggtcc tgcggacaac ggcgcagcgc cacgtcggcc
     7201 aaccgcctgc ccagcgccgg ttctcgcccc tcggcggagt gcagcgacgt gcgcagcgcg
     7261 ctcagccgat cgagcaaccg agcacggtga tcagccacgg gacgccctcc cggaggcggc
     7321 catgacggcc accatggtgg tgtggaagca ggtgccgaac aggtacgccg cccgcttatc
     7381 accgtctact ttggacaaca cagcggagtc gtgcagcggg ctcggcaccg cgccgtccgc
     7441 tcgctgcgcc gaggcgatcc gctgccaccc gtgctcgacg agtccgcggc agtgcacgcc
     7501 gaggatgtcc gcgcacagca gcagctcccc cgccagatcc aggtcgtcgc gcgccaagca
     7561 cgcaccgagc agcaccgaca ccgtgcggcc cgccttctcc cgatccgcca ggtccgatcc
     7621 ggacaccggc cgggagccga aatcggacag gtagaacagc acgtgagtca gcgcgtacac
     7681 ctcgtcgtcg gcgaaggaca acggcccttg ccgggtggtg agcacgctgt tccgatgcga
     7741 ctgatccgtc cggtacccgc tgcggtcgaa gccgccgagg tcgaggacgt agcgcagttc
     7801 gaggcggttc agcgcgggcc ggtcggcggc gaacagctca ccggtcccgg tgtccagcac
     7861 ggcttggacc agcgaacgcg cgcgggccgg agcgcgtcct gcatcggtga gcagggcgac
     7921 gagatgcgcg tggtaggcga aggccggtcc gccccggctc aactcgtcgt gaaatccggt
     7981 ttccgcgcag acggcctcgg ccacccggtg cgcggccgtg ccgatccgtt ccgcccgttc
     8041 ggcgtgcggg ccgccgcgca acaggcgaac caggatcaac agctccagca gcggggcggc
     8101 gcggaacctg cggggtggca ggaatcgttc ccagcgcgcg ggctcgaacc actccagatt
     8161 gttctccagc cagcgcagcc cgtgctcggc cactcgctcc gcggagccgg tcaccgcccg
     8221 ctcacctgcc cacgcgcagc cggaccgcga caccggccac cgcgccgaac gccagcagca
     8281 gcaccaggtc gaaaagcgga ttcgcctgcc caccacccgg cacctgctcg ccggcggcgt
     8341 tgagcagcac gtgccggacc aggtccaccg cgtagctcat cgggttcacc ccgacgaccg
     8401 cggtcagcca gctgggcagc tgatccggcc ggaacaccgc gccggacagg aacagcatcg
     8461 ggaacatcag cagcgccacg ctcgattgca gcgtctgcac ccggcggatc gcggtcgcca
     8521 ggaacaaccc gatcgcggag aacaccatgc cggccaccgt gtaagccagc gtcgcaccga
     8581 ggaatccgcg cagcgtcagc ggaaccgaca acaacggcga cagcagcagc atgatcgcgc
     8641 tctgcacgca cacgatgatc cccgtcgcga ccatcttgcc cgcgggcagg cacaccttcg
     8701 gggtcggtgc gacctgcatc tcgcgcagca ccccgaactc ccgatcccac gcgtagccga
     8761 gtcccgagtt gatcgcgacg gtgacgatct ggatggctat caccccgggg aagacgtaag
     8821 cgctgaacgg caatcccccg tccggagcga tcatgctgtt gaagccgacg ccgaacacga
     8881 ccacgacgaa gaccatctgc atcgcctgcg tcgccagcat tcccgggttg cgcaattgcc
     8941 ggatcagatc ccgctgcgcg atcacaccga tcgaccggaa cgcgcccacc gccgcgcgct
     9001 cgcccaaccc gctgctgccg ctcggacgct caagcaagtt cgtcatcgcc acctcccggg
     9061 cctgcaccgc cgctgcgggt ggcggacagg tagacgtcgt ccatcgtcgg gtgcacggcg
     9121 cgcacttcca cgacgccggt tccagcgcac ccgacgatct cggcgatcga tttctcgggt
     9181 tccgcgcaat cgacccggag agcaccggaa tccggcgaga cccgccagcc cgcggccacc
     9241 aggttcgcgc tagccaccgc atcgtcctgg gtgcgcagca aaacgctcga cctggccaga
     9301 ccgagcttga gctgatcggc ggaaccccgg cggacgagcc gcccgtcgct gatgatgacg
     9361 atctcgtcgg cgacttcggc ctcgtccatg taatgcgtgg agaacaggat gctcacgccc
     9421 agttcgtcgc gcatccgccg caggtcgtcc cacaccttcg cgcgcgcctc cgggtccagg
     9481 ccgttggtcg gctcgtccag caccagcaat cccggcccgt gcagcaacga ccgcgcgacc
     9541 tccacgcgac gcgccaaccc cccggagagg ttccggacgg cgtccgaacg ccgatcggcg
     9601 agcccgaacc tgtccagcac cgcatcgatc cgttgccggg actccttgct ccgcatcccg
     9661 aacagccggg cgtggaacca gaggttgcgg tacaccgaca ggtccttgtc cagcgtgcgc
     9721 tcctggaaga ccagcccgag ctgggcgcgg gcggcgacgg cgtcgtgccg gatgtcccgt
     9781 ccgaagatcc ggatcgtccc cgactcgcaa ggcaccgccg tgctgacggc tcccagcacg
     9841 ctggacttgc ctgccccgtt ggggcccagc agcgcggtga cctgcccggc cggggacgag
     9901 tagctgaact cgtccaccgc gagcaccgac gggtagcgca ccaccagccg gtcgatttcc
     9961 agcgcggcca ccgggccggc gtccgcaccg gtccggtcca tcaccgcagt ccgaggcacc
    10021 actgccatac cggtgcaccc ccttcgtcgt cgtccggatg cgctgcggcg tgcagcgcgg
    10081 cggccacacc ggcggcccct tcgagcaatc cggccacgtc cacggccttg tgcgtgcgtc
    10141 cgtcgctgcg ttgcccgccc gggtagcgca tcaggtgcgg gaagtggaat tccgcccgat
    10201 catcgcccag ttccagcacc gagcgcacca accgggccgt accggcgagc agctcggcgg
    10261 aaccggtatc caccccgacg cgggtgcaga tcgccaacag gcccgcgtat ccgtggcaga
    10321 tcgtcgggcc gtcgacggcc cactccgcct cgtcccgccg cagtgccgcc tgcaacgcgg
    10381 agaccgcttc ggccgtccac tcgggccggt ccagcgcggt accggccgcg tgcaacccga
    10441 tcgcgacgcc cggtgccccg tagcaccagg cggtgcgggt gatcgggcgg gtcagctcgc
    10501 tcgggcccgc gatctgctgg gccagtccga tccggcacgg ccagtacgga cctgcgtcat
    10561 cggtcagctt ccagtgcagc agccattcga ccgtgcgggt gatcgcagcg cggtgccccg
    10621 gcacctcgta gccgtacgac gccgcccggg acagcaccgc gagcgggccg ggcgcaccgt
    10681 gcgccagccc gaggttgaag tcgccctcgg ggtagtcggc acgatcgcgg tcggtcggtt
    10741 gcgcctccgg cggcacccac caccccggta cctcgtgtcc ccggacatgg atcggttcgg
    10801 tgcagcggac caggtgccgc agcccggcat cgagggcttc gcgcacccgc gaaccggact
    10861 cggccggatc gcgcgcggat tccagcaaca cccgaaccga accggaaacc ccgttgatca
    10921 ggtcgtaccc ggaccaatcc accccggcgc cctgctgggc ccgcaggtga tcgacctgcg
    10981 cgagcaccag ctcggccaac cggccggcca gtttcgcccg catccgggcg taatgaccgc
    11041 tgcccgccgc cgcggcctgc gcggccgcca gcaacgccgc cgggccggcg aacagcccgc
    11101 ggtgcggcgt gctcggcaac gcctccgccg cacgggacag gtgctcgtgc gcggtcgcgc
    11161 gccaccgggt gtcccgccgt gccagttcgc cgtagaacgc ggccactccc ggccagccgt
    11221 tggacaacgt gaccggcgcc cacatcacgt tcccgtagat cggatcccgg ttgtcgtcgc
    11281 ggccggcgac cgccgctacc cggtccggat cggcgagctt gtccgcgacc accgccacgg
    11341 cctcgtccac ccggtcccgg tccgccgccg cgatcggtgc ggccgactcc gtccggacgt
    11401 tcatccggtg aacctccttc ggttcgcgtt gtcctgcacc gctcctctgg ccagcgcgat
    11461 cacctctcgt tcgcgcgcgc tgtcaccgcc gaacaagcgg ttgcagtgca tgtgcaggag
    11521 gctgccgagg aaacgtcctt ccccgatccg gcagtcgccg tcgacccgct gccggtccat
    11581 ttccgcgcgc accgatgtga ccagctcgtc gcgccctcgc aggtggccga gcactttggc
    11641 gccgaacacc gctgccgcca gcccggtgct accgcctgcc ggatcgacca ggcccgccca
    11701 gtacgcgggt gagcggcgat accgcttcgg caggtcgcgg cgggtcccgg tgcgaccgag
    11761 ccagaactcc gccgcaccgg cgcccggatc ggtcccgggc gggccgaacg cctcggccag
    11821 tgcggcgacc gagatcgcgg cgagggtgtc caggtcgtag gggcattccg gatccgccgc
    11881 caggctcagc agttcgatcg cggccgcgct gtcggcctgg aagagccgct cgacggcggg
    11941 cgccaaccgg atcccgccgt agcgctcgtg ctccgggtcg tactggtcga tccggtgcgt
    12001 gcgcagcagg ccctcctgct gccagtccag caacgtgcga ccgagctcgg gtacgacatc
    12061 ggaccacaac cggtgcggtt caccgtgcaa ccgcagccgc aggtggtgcc cgtccggatc
    12121 ggtgtagcgc aggaagaacc accggtccgc gccgagttcg cgggccgtgt cgacgagcgc
    12181 gccgaaccgg ttgcgcagca ggtcgtcctg tccccgcgcg gtgccgtata gcttcaggta
    12241 gagccattcg ccgcccggac cgtgcgcgcg ctcgcgcggc tcccggtagg cgggagtggc
    12301 cgcgcggcgg ggctccgggt cgcgtcgccg cagcggcacc accacttcgc cgacgtgccc
    12361 ggcgagttcg ccgtgcagcc agccctcgtg ctcaccggcc acctcgtgca cgaccaggtc
    12421 cgggtccttg cgcacctctt ccaggagcag ctcgacgtgc cacgggtcgt ccaggtccaa
    12481 gcccaggcgt tggtcgttgc tcacgatcag cacgtggcgc ggcacgtcgt agcgcgcgcg
    12541 ccaccgcgcc accgcctccg cggggtcgcg cccggcagcc gcttcgcgca cgtcgtcgag
    12601 ccgccacaca gcgggggcca gcacgaatcg gccgaagcgg atccgcggca cgaacggtga
    12661 atcggccaac cggccccact tccacggttc ccacaaccgc tggccttcca ggccgatctc
    12721 ccacagcagc cgggcggcgt tcggagcctg cgccggggcg ctgaccatgt tcgccagcac
    12781 cggggtcagc tcccgtccgg tcggcaggtg caccgcgcac agccgttcca gcgtcgcgcc
    12841 gacaccgatg tcgccgagcc ggatctccgc ggcactcggc gagtcgaaca cgccgacgcc
    12901 gatccggtgc ccggtgtcgg gcgcggtgtg cgccaagttc gccgctttcc cggaacgggg
    12961 caggaaagcc aggtccgcgc gcagcgctcc ggccacgtgc gtcggcaacg ccgaggactc
    13021 ctcgtgcaac cgccgctcgt ggtccgcgtc gagggcaccg gcgaagcgca tgaaggtcga
    13081 gcccgcgtgg tgcgagccgg ggctcggcga cagcgacacc aggaattcgc cgtccagcaa
    13141 ccgctccgcg gaaggggccg cgacctgcac ggtcacctcg cacgaattcg gaacctgcgc
    13201 gggctcggcc gcaccccggc acagcgcgcg catggtcgag gcgtccacga ccacctcgcg
    13261 gtcgccgctg cgcagcgcgt ccgcgagcag gcggtgcagg aggcggtccc ggtcccggtc
    13321 gggttcggcc tcggtccgcg catccgggac atcgctgttc ggccaggaat agccggcggg
    13381 gggcccgagg ccgacgttgc cgtccagcag gtccagcagc ggaaccagcc gatccgtgcc
    13441 gtagcgctcc aagaactgcg cgtggtagtc gcgcaacgcg tgcaaaccga tcttcggggt
    13501 ggaggtccgc cacatcagct cggcggcacc ggccacctcc gcggcgaccg ctgcgggcag
    13561 ggcggtgctc ccggcgagcc gggcgtccac gtgcagcggc gtggggtgct ggtggatgcg
    13621 ctgcgcatcg gcgacggtgt ccgcgagcgc ggccgccccg gacccggccg ggatgcggtc
    13681 gtaggcggcg atgcgatcgg cgagttcgcg cagttccagg tgtcgctgcg ccaccggagc
    13741 ggcgttcgcg gcgtccagca cttcgcagag ccgggtcagc gggtccgaac cgtccaacgc
    13801 cgggcgcagc tcggtcagca gcacttcctc cgcgatcagc gaactcagca gcccgcgcac
    13861 gcgctcgcgg gcacgctcgc cgaactccgc caccagccgt tcggtcagct gcccgagccg
    13921 aacgggctcg gccccgagct ccaacgcacg gcgcaccggt gcgctgtacc gcaccgacac
    13981 ccgggcacgg ctgttacgcc cgggaaccgc cccgaaggtc gatgcgcagt ccagcaccac
    14041 ccgatcgccg cgcaccacga gcgccggatg cgcgtgcacg cgcagcgcgg gcatctcgac
    14101 ggcacgggtc tccagctcct gcacgacccc gagcaaccac tgcatgtcga cctgagtgcg
    14161 ggtgcgctgg ctgccgcgcg ccggtgtccg gggcaaccgc ccggcatcga cgtccgcctc
    14221 gaaatcaccg caagccacgc ccgcgaacaa gccgaacggc gtcggccggg tgcgcatccg
    14281 caggtcgtag cgcagcaccg cgaacgcggc ccgccgcagc tgagccggtt tgaccgcacc
    14341 gccgtcgccc gcggccactc gaagcagcag tccgcgcagg ctgggactgg ccagcgccag
    14401 cgcttccatc aggtgctcgt cctcgaccgc tcgccgcagc agccgcgaac acgcggcctg
    14461 ggcaccggcg tcggtttccg caccggtcag ctgcggccgg gtggcaccga gcggggcgcg
    14521 gagcaggtag aaatcccaag cggcgaacag gtcttcccga agcggctggg cgtgcgctgg
    14581 atcgtccatc ccggactcct cgactcgcgg gcggaaccgc cggggcgggc ggaactcgcc
    14641 ccggcggcat ccggaatcag cagcagtggc tgcagttcga gccgccgccc tcgctggtgc
    14701 acccgggggt gcagtacgaa acgctggtga cggcggggtt ggccatggtg gcctcgaagc
    14761 cgacctccag gtcgaggtcg aacaggtcga cctcggcctc ggcgacggcc tggtccgtag
    14821 cagcggacat ggttacctcc gtgatggatc ggtggtgccc ggcgggcacc ttgatcggat
    14881 tcggctgcac tcccggccgg tgccggcccc agacccggtt gcgtgcagcc cgttcagatc
    14941 agcaaccgga tctcgccgcg gcaaccgatc cgggccggaa tggcagaact ggcagtgccc
    15001 gtggcggatc tgcggccgcc gtccgccgcc cggaagttcg aaaacggtgg atgtcgccgt
    15061 gaaccttcgc gaatgccggt gctacgtacc ttcactgagg gattctggtc gctcgagacc
    15121 ggaggcgatg ggaaacaagg tgactgaggc aggcacgcac tcggccgggc tgctggcgcg
    15181 cgtcgccgaa ggcgacgagg aggcgctggg cctgctctac cgcgagcacg cgggttccat
    15241 gctgcgcttg atcgggcggc tgaccacgaa ccgggccgaa gccgaggaga tcttgcaaga
    15301 agcctggctg gcggtatggc agtccgcggc agccttccgg ggtgacagcg cgccccgcgc
    15361 ctggctgctc ggcgtggccc gcaggcaagc gcacaaccgg ctgcgccgcg ccgcgctgag
    15421 cacggcggag ctggacgcgg cggctcaggt gccgcaggca ggcccggacg tggaggaccg
    15481 ggtgctcgcg ggcatggagt tcgagcaggt gctcgcgcgg gtgcgggacc tgccccggca
    15541 tctgcgggag gtgctggacc tggtgctcgt ggagcagctg tcctaccgcg agatcgccgg
    15601 agtgctcgac gtgccggtag gcaccgtgaa aagccggatg tcccacataa aacgggaact
    15661 ggcgcagggc acgcactggg agtccagcca tcggccaccg caggaaggga gcaggcgatg
    15721 agtcacctgg acgccgacga agtcctcgag gcggctcggc agcaggccgc gggcggccgg
    15781 gtgcgctccg cggaccacct ccgcgaatgc gcgcggtgcg cggacggcgt cgctgccatg
    15841 gcgcggttga ccgccgcggg cgaagtgctg gccgcggagg aggatcgcga gctggcggtg
    15901 ccctcgttcg agcacgtgcg ggccgcgttg ccggggaacc aggcccgcac cggcccgcag
    15961 cgcgaaccgg cgccgcgggg cgcgcccgag cggcggggga agcagctcct gcggttgacg
    16021 gccgcgttgg tatgggcgca gctggcgctg ctgccccgcc tgctgctgcc cgccagcgcg
    16081 ttcgctttcg ccgctgcggt cgtgctcgcc acggcgctgc cggaaagctc ggccgggctc
    16141 cgggaacacg ccttcggcgc ggccgtggtg ctgatcgtgc tggccggggc gctgaccacg
    16201 tattcgggtg ggcgcgatcc gcgcaccgag ctgcaattca gcctgcccat cgcacccccg
    16261 acggtgttcg tctgccgggt ggtgggcgtg ctgggtctcg acgtgctgct cgcggtgctc
    16321 ggttcggtcg cggtgcacgt gttcggcggg tcgccgagcc tggccggtgt cctggcgagc
    16381 tggttcgggc aggcgttgct gaccgtgggg gtcgccctcg tgttcgcggt cgcgcacgcg
    16441 ccggcgaccg gcacgttggc gggcgtgctg gtgtggctgc tcggttcgtc cagcggtctg
    16501 ccggaagccg gtgggctggg cggaatcctg cgcccggcgg tttcgacgct gtggaccagt
    16561 tcgcccgcgg tggtcgcgct ggcgctggcc ctgctggcga tcgcggtgct ggggatgcgg
    16621 ttcccccggt tcgggccgcg ccgggagggg agctgaacca tggccgtgaa ccgcatcgag
    16681 cggcggcgct acgtaccggg tatgcgttcg ttgtcgcggt acgaaatgcg ccgctgcggt
    16741 cctgcggtgc tcgcggtgcc gccgctggcg ggcatcacgg tgggcatcgc gtcctcgctg
    16801 gccggatggc agtcgttgct gctcggcgag gtcctgccgg ttctcgtcgc gcttcccgcc
    16861 gcggcggtcg cggatggcga tccgctgcgc gagctgcacg agacgctgcc tcgtcgctac
    16921 gtgcgcacgg ctgcttgccg gctggggatc gcggcgggtg cggtgctgac cggtgtcgtg
    16981 gccgctgcgg tgctctgcgc cgcgttcggc ggaggcgcaa gcgtgctcgg gcacgcggcc
    17041 gccgcgttgt gctccgccgt gctgctcgtc ggcatcggcg cgctggtggg cgcagcgtcc
    17101 tcgtccgcgg cggccgcatc gaccgcgatg atcgcggtat ggctcgggca gctgctgctc
    17161 ggtgaccgca tcctcggcga cggcgccgcg cgactgctgg taccggcctg cgtcggttgc
    17221 gccgcgctcg cgctggcgct gcgccggttc gactccggcg ccgacgtgct cggcgctgcc
    17281 cgcagcgggg ccgggtcatg accgcgcccg gagtccggac ggtgctcgcc accgcgcgct
    17341 acgaggcgct gatcgcgctg cgcaccaagg cgctgtggtg gtcgctgctg cccctgaccg
    17401 cactggcgct gctgctcgcc gccacgtccg gtcgggtggt cggcgccagc gacccggttc
    17461 gccgggtggc cgagacttcg ctggtgttca gcctgctgtg cacgctgggc atcgcggtcg
    17521 gcctcgccgg acgactggcc gggcaccgcc gcagcgggct gaccgatctg ctcgacgcca
    17581 ccgccgcggg catcccggcg cgcgtggcgg gctcgctgct cggttcactg ctggtggcac
    17641 tggtgccacc ggtctgcggt ttcctgctgc tggtcgtggt gacctcgatc agcacgggcg
    17701 ccccggcggc ggtcggcgcc gggctgctgg cgatcgtggt ggtgctgctg ccggcgagcc
    17761 tgatgctgag cagcttcgcc gcgatgctgg gcgtgctgct gccggttgcg gccgcccgcg
    17821 tgctcacggc ggtgttctgg ctgtgggcga cggtgctcaa cccgatgctg ctgccggtac
    17881 cgaccgcgac cggcacggtg ctttccccgc tggcgcggta ccccgccgca gcatggctgc
    17941 acgcgtcacc cgcgtccgcg acctacggcc tcagcggcgc gctgcgccca gaagtgcaca
    18001 gcgccacagc cacggcgcaa gtgctgtgca cgctcgccgc gagcgcggtt ttcctcgcgg
    18061 tcgcggcgat ccggctgaac gcacgtaccc gagttccgaa ccggagggca cgatggatgt
    18121 ctcgctcagc gcagtgacca aggtctaccg gggtggcgct cgcgtgctcg acgggctcga
    18181 cctcgagatc ggcgaaggaa tgctcggcct gctcggcgcg aacggggcgg gcaagaccac
    18241 gttgatgcgg ttgctgacca cggtgctcaa accgaccagc ggccgcatcg cggtcggcgg
    18301 ccacgatctg tccacccgtt ccggggtgca cgcggtcaag cgcatgttgg gctacctgcc
    18361 gcaggaactt tcgctgtacc cggagctgac cggtgccgag ttcctggact acgtcgcgct
    18421 gctcaagggc atcggcgacc gggccgaacg ccggcgccag accgacgacc tgctcgagca
    18481 ggtgggaatg cggcagcacg cgaagcagcg catcggcgac tactccggcg ggatgaagcg
    18541 ccggatcggc atcgcgcagg cactgctggg cgatcccgag ctgctcgtcg tcgacgagcc
    18601 gaccgccgga ctcgatccgc aggaacggat gcgcttccgc gcgctgctgg cggggctgtc
    18661 cggcgtccgc atcgtgatcc tgtccacgca catcctcgac gacgtggcgc agagctgccc
    18721 gaacgtcgcg gtgctcggcg acggcaaggt cgcctaccac ggcagcacgg ccgggctgac
    18781 ctccgcggcg tccggccgca cctacctggt gccaccggga cggccggttc caccggattc
    18841 gacggtcgtc aacgccgtcg ccggccccga aggcaccgaa taccgcgtga tcagcgagaa
    18901 ccccgttccg ggggcgcggc aggtggaacc gtcgctcgag gacggctacg cggcattggt
    18961 gcgcaacagt tccgacaaga tggcggtgaa ttgatgagga cgttgacgaa gctggtcctg
    19021 ctgggatccg cggcgctggc cctgaccggg tgcggtggcg gtggccaggg caccgcggag
    19081 gcgggtgcac cggtgccgat gccgcccgcc cgcaacggcg agcagccgat cagcgcggcg
    19141 aacatggggc acttgtggcc gctgaccgtg cccggcggtg tgctcacctg cgtcggcgac
    19201 aacgaggccg tgttcaccga tcccggtggc cgctcctacg cgctcaacga gcgcgccgag
    19261 cggcaccacc ccagcatcga gccgctgcgc gcccagggcg agggcagcga gaagatcagc
    19321 ctcggcgcgt tgcgcagcaa gaccctgaaa ctttgtcccg agcagcggtg aggcggccgg
    19381 ttccgcgctg cgccgctcgt cagcccgcac gccggctggt ggccagcaac gagcggagtt
    19441 cggcgcggct ggaaacttgc agtttgtcgt agagcatccg gatccgccgg tacagcgtcc
    19501 gctcggagca gaagaaccgc cgggctatcg cggaaacggt ctcctcgctg cagagcatgt
    19561 tcttgagccg gtccagctct tcgtcgtcca tcgtgggctc gcccgcgaat ccggccgcgc
    19621 gctcgtacgg cgccatcagc gcgttgctca cccgggtgtc cgcatcggca cgcgaattcc
    19681 ccgcgttgat ggcggtggcg cgcacggcct cgagctgggc accgaccggg atcgcgaggt
    19741 tcaacaccga ggatgccccg tgtttgatgg cggagtacgt ctggtgcccg ttgtagtcgt
    19801 gcaccaccgc gaccacgggt gaaagccaat gcccgcagtc ccgcagattc gaaatgcagg
    19861 cggcctggtc ttcgctggtg gcgggcagaa acaccggatt cccgttgtcc gccagcgcct
    19921 ccactccgga cgcctcgaag aactccacgg cgaagccgaa ctcgggcaac ggcaaggtgc
    19981 ccaccatccc ggataccagc gccttcaggt gcgcgtgcac ccgagcggta agacatccgg
    20041 gaaggtgctg cgcacaggcc tgcggccggc gcttggccgg tccgtcggcg ggcaagtgcg
    20101 tgatcgcgcg cgcgtcgaat ccgttcgccg ggcgcggaca atcgagctca ttcgttctcc
    20161 ccacagcgac accccagtcg agcacaagaa atcatggcca ggcgcagccg cggcaaggtc
    20221 cccagtatgc cgaagcgcgc cttccgaata accccaggtg gtactgaacg ccgtcacctt
    20281 agcacagcaa gatccatcac ggctcgctga tcggacggcc gttttcggcg catgcgctcg
    20341 aaccctcggt tgcgaaaccg tgcacccgat ccttcggatc tgcacctccg gctgcaccgc
    20401 gccgcaatgc gcgcggaact gccaagaact gccatccggg tgtcgaccgg ctttcccgca
    20461 gccggtccga tgcgagtctg gccaccggtt tgtccacagc ggtgcaagga gaggaagcga
    20521 cgatggactt cgccaccgcc cggacgctgg tgcgcgccgc gacgctggga atcgacgacc
    20581 tggagcgggc gatcgcagca gcgggtgcct gcccggccgt cgacttcctg ctcgacgaaa
    20641 tccgcccgcg gctgcggctg tccgagcttt ccgagttcga ccaggacacg atcgtgcggc
    20701 tgtgcctgca agcgggcgcg gagacggtgc accgggactt ggtcgtgcgg cggaacggat
    20761 ccggctgggc gttcggtccg tccggcgaac atccggttgc ggcggccgcg gtcatcaccc
    20821 aggacctcgc cgaagcgctc cgcggaaccg tctcgccctc cggtgcgagc gcggcgaccc
    20881 gttccgtgca atggcgggac gcggacgact tcaccgcgtt ccactcccca ccggccgcgt
    20941 tccgcgtggt gcagcgcttg ctcgcggcaa tggagcgtcg cgacgaccgg gacctgagcg
    21001 cgctggccgc gcaccacggc tcggacaagt gggggctgca caactacacc ccgcactacc
    21061 agcggcactt cgagccgttg cgggacgagc cgatcgtctt gctggagatc ggggtgggcg
    21121 gctaccagga cccgaccggc gggggcgcat cactgcgcat gtggcgggat ttcttcccgc
    21181 gggcgctggt gtacggattg gacgtcgtcg acaagagcgc acacgacgag ggacgcatcc
    21241 ggacgctgct ggcggatcag gcggatcccg ggtcgctgag ccgcgcggtg gagccgatcg
    21301 gccgcccgga catcatcatc gacgacggca gccacatcaa caagcacgtg ctcagcacgt
    21361 tccgcgcgct gttcccgctg ctgcggccgg gcggcaagta cgtgatcgag gacctgcaga
    21421 cggcgtactg gccgagcttc ggcggtagcg agcagtccac ctgcgatccg cacaccacca
    21481 tcgggctgct gaaggacctg gtggacggtc tcaaccacca ggagctgacc gagcgcaatc
    21541 cccgcagcag cagcacgacc gacacccaga tcgccggggt gcacttccac cacaacctgg
    21601 cggtgctgga caaagggctc aacctggagc cgggcgcgcc gtcctggctg gcccggaccc
    21661 agccggagtc ctgatggccg cgcgcatcgc cgtcatctgc ccggcgttca accgctccgc
    21721 ggccatcctg ccgacggtgg aaagcgtgct ggcgcagacg gtgcaggact gggaactgct
    21781 cgtcgtctcg gacggcagca ccgacgacac cgacgaggtc gtccgggcgg tgcgcgatcc
    21841 gcgggtgcga ctgctccggg tggcgaacca cggctgcccg ggcgggccgc gcaacgcggg
    21901 tctcgcggcc acgtcggctc cgtacgtggc ttatcttgac cacgacgacg tgtggctccc
    21961 gaaccacctc gaagtcctgc tcggaatgct ccaagccggt gcgccgctgg ccgggaccgg
    22021 atgtgtgcgg gtgggtccgt ccggacgggt gcggcaccgc tccggagtgc tggattccgt
    22081 ctggcacccg gaactgcagg ttctcaacgc gatgtacgaa ccgtcccgcg tgggccacgt
    22141 gcgcccactg gtcgccgagg cgggcggctg gagcacggcc gcggccgggt tcgaggactg
    22201 ggacttgtgg acgcggctcg ccgagcgggg cgtggacttc gcggtagcag cggaccggac
    22261 ttcggtgctg acgctggagg acggcagcag gcggcacctg ttcagccccc ggcacagcat
    22321 cgggctggcc aagaccggcg cggaacggga cgcggaccgg gtgcgcgacc tgctcgccgg
    22381 tgagcacggc cgcgcccggg ccgaagcggc gtacctcgcc gacacggaag cttggtacgt
    22441 cgacctctgg gattcggcgc gctgcgtccg gccgcccgaa gtgcggcggg tcgacgtgct
    22501 cgaagcggtg cgcgcgaagc tcgcttccgg cgaggccggt tcgttcctgc acggcttggt
    22561 caccgtcccg cacgcgggcg ggttcgtgct cgcactgccc acggcggtgc tgaatccgca
    22621 gcaccgcggc cggatccggg agctgctggc ccgccgctgc cccgcgcagc tgcggttgct
    22681 gcgcgaactg cgcgcccagg catcgaccgg tgcgctctga acgacgttcc gcccggccga
    22741 gcgcacacct gcggagcacg ccgaagcggg ctccgcggca gtcctgccaa cagcctgcca
    22801 acggccgcgc gaaccggtgt gccgggtgat ccgcggtgcc aggctcggat cgcgatcggg
    22861 tcgaccgccc gacgttcccg caacgattcc cgaggagggg atttccgtga cggctcttcg
    22921 ccgcatgttc atcgccggcg tcaccgcttg cgcgctcggc ggcctggtcg tgccgaccgc
    22981 cgttgccgcg accggcaccg cgcaaccggc gccggccacc gagatcgggg tccgcaagac
    23041 ctggcacgcg accgtgcagt gccacatcgt gcgcatcagc gacaaccacg tcatcggtta
    23101 cgaccgagcc gacggcgtgg gcaacaccaa ggacaaagcc atcaccgacg ctgagcgcaa
    23161 cgtcccggtg ccgcagggac actacaagcg ccactgcgat cccaagcgga tctggtaact
    23221 tccagcagct tcgttccgct cctccgctga tcaggttggt gtgcgatgtc cgaggaaagt
    23281 ggaatctggg aaatccggct cggcatttac gccaccgagc agcaggccga agaagtcaag
    23341 gagcgcatca ccaggctgtt gtgcccggat cccgaccacg ctccgccgtg cccgatcccg
    23401 tggtcggtac ggctgatgcc ggaggatgcg gacagctacc cggcgctcgc cgagcaagct
    23461 cgcatcgaag gccacgacca ggggtgagcg gcccggtgga ccgcagcgac ggccgcggat
    23521 gcgggccgca tcggggttcg caccccggtg cgcccgcccg ccgggcctgg tgagctgggc
    23581 cgataccatg gtttcgtgag tacagcggtg gacgagaatc acgaggacct gccggagcag
    23641 atgcgcatcc ggcgggagaa gctggaacgc ctgcgggaca acggcgtcga cccctacccg
    23701 gtcggttacc cgcgcagcac ctcgatcggt ccgatccgcg agaaacacga cggtctcgaa
    23761 gccgaccagg gcaccggtga agtcgtctcg gtgaccggcc gggtcatgct ctaccgcacc
    23821 ggcggcaagc tgtgcttcgc cacgatccgc gacgacaccg gttcgatcca gatcatgctg
    23881 gcgctggaca aggtcggcgc ggacgagttg gaagcctgga aggccgacat cgacctcggc
    23941 gaccacgtcg gcatcaccgg cgaagtgatc acttccaagc gcggcgagct ctcgatcatg
    24001 gcggagagct ggacgctgac ctcgaagtgc ctgcgcccgc tgccggagaa gcacaagggc
    24061 ttgacggatc ccgaggcgcg ggtgcggcag cgctacgtcg acctgctggt caacccggaa
    24121 gcgcggcagc tggcccagca gcgttcgcgc gccgtgcagg cgttgcgctc ggtgctgctg
    24181 gagcgcgact tcctcgaagt cgagacgccg atgttgcagc aggtgcacgg cggcgccacg
    24241 gcggagccgt tcaccaccca catcaacgca tacgacctcg acctgtacct gcggatcgcg
    24301 ccggagctgt tcctcaagcg gctggtggtc ggcgggatcg agaaggtctt cgagatcaac
    24361 cgcaacttcc gcaacgaagg cgcggactcc acgcacaacc ccgagttcac gatgctggag
    24421 ttctacgagt cctacggcga ctacgacacc gtcgccgaac tgaccaccca gctctaccgg
    24481 cacgccgcga aggccgtgtt cggcgaccac gtggtgcgcc accccgagca cggggacgtc
    24541 gacctcggcg gcgaatggcc gtcgatcacg ctgttcggct cggtctccg
//
