LOCUS       NZ_JADDUE010000015     24798 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Saccharopolyspora sp. HNM0986
            NODE_15_length_118167_cov_70.519348_cov_70.519348, whole genome
            shotgun sequence.
ACCESSION   NZ_JADDUE010000015
VERSION     NZ_JADDUE010000015.1
KEYWORDS    WGS; RefSeq.
SOURCE      Saccharopolyspora sp. HNM0986
  ORGANISM  Saccharopolyspora sp. HNM0986
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (bases 1 to 118167)
  AUTHORS   Li,F.
  TITLE     Diversity and distribution of actinomycetes associated with coral in
            the coast of Hainan
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 118167)
  AUTHORS   Li,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2020) chool of Life and Pharmaceutical Sciences,
            Hainan University, 58 Renmin Avenue, Meilan District, Haikou, Hainan
            570208, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 232.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016526145.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 02:15:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,899
            CDSs (total)                      :: 5,838
            Genes (coding)                    :: 5,784
            CDSs (with protein)               :: 5,784
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 7 of 54
            Pseudo Genes (incomplete)         :: 49 of 54
            Pseudo Genes (internal stop)      :: 0 of 54
            Pseudo Genes (multiple problems)  :: 2 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:09:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 93369
            Orig. end                         :: 118167
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADDUE010000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24798
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24798
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24798
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:15305](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15305
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(781..790)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.31"
                     /tool="antismash"
     gene            complement(928..1458)
                     /locus_tag="INP57_RS26775"
                     /old_locus_tag="INP57_26785"
     CDS             complement(928..1458)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS26775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_26785"
                     /product="hypothetical protein"
                     /protein_id="WP_200073130.1"
                     /transl_table=11
                     /translation="MTQLWSVAGGLALSVGVLSGCGVQDGVGPTGPVTPDTAAVPNPAG
                     QADRQPNTFQFGQTYEGEIDTTVRKLDPFQFNTSEFAAPQGGVPAWGVEFEFTNRTDRA
                     FPLAVLNIGATVDSRAAEEIFDGKNGFNGLLSAPPLGPGQTVKVPVAYTGQGSKHVITV
                     ASLDFSKSATFTD"
     misc_feature    complement(1645..1665)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.17"
                     /tool="antismash"
     misc_feature    1740..1758
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.47"
                     /tool="antismash"
     gene            complement(1818..2528)
                     /locus_tag="INP57_RS26780"
                     /old_locus_tag="INP57_26790"
     CDS             complement(1818..2528)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010234920.1"
                     /locus_tag="INP57_RS26780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26790"
                     /product="creatininase family protein"
                     /protein_id="WP_200073131.1"
                     /transl_table=11
                     /translation="MDVLTTATSADEAARKARVAVLPVGSFEQHGEHLPLTTDTVIACL
                     IAQRIAEDYDLFLLPPITVSCSHEHDSFPGTVSVSATTLVAMIEDIRVSLRRSDITKLV
                     LVNGHGGNYVLSNITQQANTDERCVVLFPGGGDMNRAREHAGAVTSSHEDMHAGELETS
                     LLLHAHPHLVGESYYRADHQADDRPHLLTLGVEHYSPSGVIGRPSEATAAKGRAILDSL
                     STSFFEHLTLIDPR"
     gene            complement(2554..3927)
                     /locus_tag="INP57_RS26785"
                     /old_locus_tag="INP57_26795"
     CDS             complement(2554..3927)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS26785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_26795"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_200073132.1"
                     /transl_table=11
                     /translation="MRSEAGRSETSRHCARCGSKLARDNAAPVCSPCRRAPKNHQEAGP
                     RVGDEFWAEDRLRQALAGKDMGAVVRAYRVHPAHGRKPLPQADVAKWLSITQSQLSRIE
                     SGRNRVRELDQLRHYARQLRIPPELLWFDAGDSADEPVPPKHAAVVLPGGPSVPAANVR
                     TEPALAESLLMTLKQYITTDNLVGPRSVLPVAAKQASFANGLLAQSQGQSHRSLLYVAA
                     RFAEFTGWLDQDAGKLQEAMAWSNTALDLAHEAEDAHLASYIHMRKSNIASDAHKPALT
                     IDFAQAALRSSETLSPRLKAVALRQEAHGHAMAGDYEGCSRAIDRAFRYAADEPDDESD
                     IARYCTPSYVEMEAAHCWVELGKPVKALATLQQGIANWHADFRRDLGLGLARLAVAHAV
                     ADQPEEAVAVARHSLTIATETRSHRTARQLRRTSQLLADAGAHDQASQLSRTLRTTLA"
     misc_feature    4085..4100
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.03"
                     /tool="antismash"
     gene            4599..4874
                     /locus_tag="INP57_RS26790"
                     /old_locus_tag="INP57_26800"
     CDS             4599..4874
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS26790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_26800"
                     /product="hypothetical protein"
                     /protein_id="WP_200073133.1"
                     /transl_table=11
                     /translation="MIQQHTSAPPKTGDVVELGKQIHDRLGEVLFALPGRSTVTYEELG
                     DLGARLRGLAKIFDRYAPTRPMAERPGSATAPQENARVWVFPGQQR"
     gene            4898..6469
                     /locus_tag="INP57_RS30450"
                     /old_locus_tag="INP57_26805"
     CDS             4898..6469
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.5"
                     /locus_tag="INP57_RS30450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26805"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_200073134.1"
                     /transl_table=11
                     /translation="MLPDTSAPAGRGLCRQDIPPPAAQTTTPRRRAGIDIGSAPHRCRS
                     GSRAAPEPVSAPKENRLAMRGLDHHARPERISPRLDPRVVIESPGRRVLVFRTHPRPLI
                     AESLDLVSILTWLDRLRLPRRICLPIRAEAPTQRHTVLSGELCMNRGISVVSLSVGRLL
                     GHTYGQSLGDALATASPKDPATVAAVVRTHLHTATAISDELIRQVAADLALPPGQLADL
                     LHTPRPLLLNPTARALIAGLRDACPDIRVVVCSNLASADHVHANAVRDELGPLLDAAYF
                     SCETGLAKGNGPAMFEHLARNHSVEIGEIVHVGDTLLEDVQAPLLAGARALWVHADHAR
                     TPRVAGPDRYRAVPDLAEAIRELREWIPESQPRPALPVRAAALIRDVQQRILLVRGPDD
                     EDFSLPGGRCEATGSDSPPTAMAREVHEELRLAVTPGKLVWAGWSEAESATGENKIHFL
                     FEAHIVGTSVPVPDASEVAEIRWSGHHEALRLLHPAEADRLHRIGCDRSHGWQYDTTRP
                     PRAQGP"
     misc_feature    6023..6025
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6481..7359)
                     /locus_tag="INP57_RS26800"
                     /old_locus_tag="INP57_26810"
     CDS             complement(6481..7359)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.4"
                     /locus_tag="INP57_RS26800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26810"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_200073135.1"
                     /transl_table=11
                     /translation="MPGPNTPQRALLARRLRELRATAFASGSALARHLDWHQTRVSKLE
                     QGSQRPTDDDLRRWGEAVDATAEQLDELFELAEAARIEYATFGQRYRQHGGAVAEQQAT
                     TNEDAASARIAEFQPAMMPGLLQTAAYAREVLTRPCGPASAGVADEEIDQIVGKRMERQ
                     QVLYQPRQEPIRIIMGEAALHTHFGDPRTLAGQLDRLLALLGYSQVDIGVVPFTAAMPV
                     FPLTNFLLYDDHVLIESLTAQQRLDSPDDVRAYEDFFAQLHDAAITGAQLETLLAQSST
                     ELRRRSGAASS"
     gene            complement(7375..7914)
                     /locus_tag="INP57_RS26805"
                     /old_locus_tag="INP57_26815"
     CDS             complement(7375..7914)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF045158.2"
                     /locus_tag="INP57_RS26805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26815"
                     /product="DUF6879 family protein"
                     /protein_id="WP_200073136.1"
                     /transl_table=11
                     /translation="MTPAQDLREGIDQLRHELAAFRYSLFRLETLQNYSGSSEDDAFAE
                     WRRTGRIPVTAELQQWCERTRHRVGQGCRLQRVHVVTEPLTDYVRFELASYAPNVQAGE
                     DVRIIPVRGDQWPTDVHAADYWLIDARRLWTMRYSPDGAWLGAEPTTDPQCIADACAQR
                     EAAIAQSISWSEYDSR"
     gene            complement(7911..8129)
                     /locus_tag="INP57_RS26810"
                     /old_locus_tag="INP57_26820"
     CDS             complement(7911..8129)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS26810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_26820"
                     /product="hypothetical protein"
                     /protein_id="WP_200073137.1"
                     /transl_table=11
                     /translation="MHLHKICKDPESNPTGCQSVYLAENGMMAVQGLEMDPETFANMEN
                     LLPGESGVLIKPEILVEVARLYQEKAL"
     misc_feature    complement(8107..8123)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.97"
                     /tool="antismash"
     gene            8380..9690
                     /gene="fxlM"
                     /locus_tag="INP57_RS26815"
                     /old_locus_tag="INP57_26825"
     CDS             8380..9690
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155777.1"
                     /locus_tag="INP57_RS26815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26825"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_307850304.1"
                     /sec_met_domain="PCMT (E-value: 6.2e-39, bitscore: 126.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSSEQDPDDSLEPAASPATGATPIQPPRAAMVQRLWKLNALRS
                     ERVAEVFATVDRHVFAPSVPAEEVYDATTAVRTKWDEHGSAISSISAPQIQAFMLEQAD
                     VRPGMRVLEVGSGGVNAAMLAELVGDTGTVTTMDIDPEITGRARKLLDAAGYPQVHVEC
                     ADAEHGVPARAPFDVALVTVGCWDLPAALMDQLAESGRVVVPLRMRGITRSLSLRRAGD
                     HLLADSAEVCGFVKAQGLGAHQERMLLLHGDRIALRFDDGTAPADSARLDGALGTDRVD
                     VWSGITVEAMEPFDSLGLWLASVLPGSCRIAVDPDYDPDTDSGPAMVVPEGRWFPDAYV
                     NSHEDSFAYLATRRLDDGLFEFGAHAFGPHAGEAAEAMVEQIRAWDRDYRHGPDPSVAV
                     WPYDAPDEALESPDAAATTVIPKRHTTITISWPHPSA"
     gene            9741..9926
                     /locus_tag="INP57_RS26820"
                     /old_locus_tag="INP57_26830"
     CDS             9741..9926
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498823.1"
                     /locus_tag="INP57_RS26820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26830"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_200073138.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.4e-16, bitscore:
                     53.0, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAANTTTLSRTEDVDISDDFTLDFQVIESAYPLAKLSCDTDDGCG
                     QTCSTSACNSQANNPS"
     CDS_motif       9741..9839
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAANTTTLSRTEDVDISDDFTLDFQVIESAYPL"
                     /locus_tag="INP57_RS26820_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9840..9926
                     /prepeptide="core"
                     /locus_tag="INP57_RS26820_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-12.10"
                     /molecular_weight="2634.7"
                     /monoisotopic_mass="2633.1"
                     /core_sequence="AKLSCDTDDGCGQTCSTSACNSQANNPS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAANTTTLSRTEDVDISDDFTLDFQVIESAYPL"
                     /leader_location="[9740:9839](+)"
                     /alternative_weights="2652.8"
                     /alternative_weights="2670.8"
                     /alternative_weights="2688.8"
                     /alternative_weights="2706.8"
     gene            10001..13090
                     /locus_tag="INP57_RS26825"
                     /old_locus_tag="INP57_26835"
     CDS             10001..13090
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="INP57_RS26825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26835"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_200073139.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.6e-182,
                     bitscore: 598.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.7e-18,
                     bitscore: 57.8, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATPCLFRHAEFVLVRASTDPGGLSLPRLDLHTAEDAETTGREWL
                     TELWGRDVVRTAFGVASPALCEQIAAAVDGAKLNRRSWRRLLVSTCSYVLRWQQRPTPF
                     GLFAGVTTAAIGGSTHVVFGEQHQPHRQIDPNWLHKLISELESDPEALAKASLVVNNAG
                     TVRGDRFVVPNHLSGTADEKSSAQVAAGLDEVELALRRTRPVDAALAAARVPIPGRMLI
                     DRLHREFPSVPREQVTTLISGLVAHRVLVTSLRAPASYPKPAEHVLAQLDDSHRDSDEN
                     DRVGDAREALRSFFSSGSQAKSTVSEATSSARSTPPTSVDVSLDGRITLPEPVLCEAES
                     AASVLLEVSPSPFGTAPRRDYHLRFRERYGSGALVPVRELVSDSGLGFPTGFLGAAREQ
                     GARFLTDRDAALQAMLQETVLDGRTELALSEELIEQLSVGDHRDLTPPERVELAFTIHT
                     TSTEALDQGRFQLWVTGAPVPTSSMAGRFASVLDEHARQRLSRTYPQGDEVMVAQLSFA
                     PRRIANEAVTRTPDLLPWLLPIGEHPPELGADSARLLHLDDLAVTASSTQFFLIHRPSG
                     KPVHPYVPHALETTVYTPPLVRFLAELPTARRAVFGPIDFGASRTLRFLPRIRHGRSVL
                     SPARWLLHVTDLPGARAASSEWEQALKRWRERWRVPAHVLLVEGEQRLPLDLDEPTQRS
                     LLRVRLNRAGKAELREAGDPARRGWTGRACEFLVPLTASPIPPAPPVSRKVVVRDDSVG
                     SPARNDGAFPGTSSLVLSTLEGHPQRFDTILADHLPNLHQHLDNEIQRLWFRRHHDTTR
                     PDSDHSLQLWLRLTSADRYGSATTCLAEWAEDLRASGLLAQVSFETAWAQPGKYGDLSA
                     AEWVFATDSAAALAEISCAEQLQLARAAVAAVSMVDLATALASDAKKGWEMVIASLPQQ
                     TGPLDAVLRENALRFARDLRQDQPAARDDVLRAAWAERREALETYRAQLDRPPESVLRA
                     LLHEHFRRTIAVSREQEEITNRLARAVALQALALTQRGVE"
     misc_feature    10142..10144
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10469..10771
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_INP57_RS26825_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.00E-18"
                     /identifier="RREFam001.1"
                     /label="INP57_RS26825"
                     /locus_tag="INP57_RS26825"
                     /protein_end="257"
                     /protein_start="156"
                     /score="57.8"
                     /tool="antismash"
                     /translation="LVVNNAGTVRGDRFVVPNHLSGTADEKSSAQVAAGLDEVELALRR
                     TRPVDAALAAARVPIPGRMLIDRLHREFPSVPREQVTTLISGLVAHRVLVTSLRAP"
     misc_feature    11657..11659
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13087..14319
                     /locus_tag="INP57_RS26830"
                     /old_locus_tag="INP57_26840"
     CDS             13087..14319
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498825.1"
                     /locus_tag="INP57_RS26830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26840"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_200073140.1"
                     /sec_met_domain="LANC_like (E-value: 1.9e-49, bitscore:
                     161.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRHHFAAPGTTKHAELLSVLATPLTEPDAGQPELAQSLSRGAAG
                     IALWHLERAHHDVPETRPLLHQWVRAALASPISSAETAGLHAGLPAITFLLHLAEPVLP
                     EYRPAITEFDQHLRRLAHRRVDAALERIRHGLPTRFAEYDLMRGLTGIGHLLLHHQPGS
                     DALARVLDYLVRLTKPITADGTTLPGWWVDHAPDQLLPTPGGHSNLGIAHGITGPLAVL
                     AHAARRAITVDGQYDAIERICAHLDHWQQDSNAGPWWPYWIDHHDYVLGRLTNHQPGRP
                     SWCYGTPGIARAQQVAGLATGDTTRQHVAEEALLACLNDASQTDLISDIGLCHGWAGLY
                     LTAARTAHEAATPDLAAMLPSLAQQLVRHNEATPPPELGLLNGATGVALTLHAARTGIP
                     TSGWEQCLLIS"
     gene            14301..15305
                     /locus_tag="INP57_RS26835"
                     /old_locus_tag="INP57_26845"
     CDS             14301..15305
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="INP57_RS26835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26845"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_200073141.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.1e-38, bitscore:
                     123.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPDQLNTAAAPAELIATAIRSVTAGEILTEAAAAHDLDVGELAD
                     ALDTYDRAGRAAVYDRAADATWWQAHLEFSAWDQAELVAASALAPLLNAWSRTGLLRQW
                     WFIRKAPSWRLRLQPDTDHDALHTHATTELDRLVQHGHLASWRPSHYEPEALAFGGPTG
                     IRIAHTLFSADSANLLAHLHTRHVPLGRIELSMLLCTQLFRAAGQEQFEAADIWHRVTY
                     LRPHPQHTSTDTGHHTDLTQQLRTMLTYARPTGPLFAPEGPLHAAHDWAHAFHQAGRDL
                     ARAAQESKLHRGIRHILAHHVIFHWNRLGLDTNTQHALAHAATCALLPLETTL"
     gene            complement(15440..15928)
                     /locus_tag="INP57_RS26840"
                     /old_locus_tag="INP57_26850"
     CDS             complement(15440..15928)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS26840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_26850"
                     /product="hypothetical protein"
                     /protein_id="WP_200073142.1"
                     /transl_table=11
                     /translation="MSQDLDELMRGFEDTFGYPPDDNVVTRSEEGGESEAIAELSSMGA
                     PSGLLEFYSEVHEVSLPDVQNGLFIESATAVVDGAKDGQPTRVTGAVEDSIIVIGSDGG
                     GGLFALSRSDGRIYLLQGGALVGSTYEVESGGVDVIANDLTILLESIHQKVREALHDA"
     gene            complement(15942..20459)
                     /locus_tag="INP57_RS26845"
                     /old_locus_tag="INP57_26855"
     CDS             complement(15942..20459)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787564.1"
                     /locus_tag="INP57_RS26845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26855"
                     /product="RHS repeat-associated core domain-containing
                     protein"
                     /protein_id="WP_233628340.1"
                     /transl_table=11
                     /translation="MSPGDVGVAMADFPEHLFSLGGSPEAIAGSARRYDRFGGSASHAA
                     ERITGMDTGEFQGPEAEQFRDKIDSELPPDLRVTGTAFSQVGTALNTFSSRLSELQGKM
                     RPLAHQAPGLWEQLKASEGRVERAESADRAHADKVRDAQAHAPAGHAPPPGAAYESDAG
                     DASAALSSARAAWQDCVDKANGLRTEMTAAARECTNRINDAKGMRFKEPPAGYDLIGQG
                     QDFIRENKDVLKEISSALKVVSGALAVIGVVLQAIPVVGNAVGGAFLIAAGITGGAALA
                     IDAGIYAATGEGSLTSILVDTALTVIPFGKVAKLGSKVVGGLSKVAKNARGTKHGGDLA
                     SHTDETKSLTTGGDPIDVNSGRMLQTQTDVELDGVLPLVLRRTHLSSYRIGQAFGPSWA
                     STLDQRLEVDGDGVYFASDDALALAYPDPMPGVTVLPRVGPQWPLIRTEDGEYVITDVE
                     QGRFLHFTQHDAHWPLTAITDRNGHRIDFVHDDTGLPTEVRHSGGYRIRIESTDRLVTA
                     LYLCGADNGADVPLMRYRYRGDRLTEVINASGQPMRFDYDDAGRIIGWKDRVGSSYRFT
                     YDGEGRCVRGEGADGFLSCTLAYDSDNSITYLIDSLGNQTEYHLNDDGKIIREVAPLGS
                     ETLSEWDEHRRLSSRTDPLGRTTRYWYDDNGNVTTVLRPDGNRISVEYNELRQPVTMTA
                     PDGTLKRHEYDDAGNLTRVIDPVDAVTTYGYNERGHLTAVTDTLGHTSTVETNAAGLPT
                     AITGPTGGTTRYERDGFGRVVASIDPVGGVTRLGYTVDGKPAWRVLPDGATERWLYDGE
                     GNLRTHIDPLGQTTRTEATHFELPSAEVRPDGTRLEFGYDTELRLVSVTNQRGLVWSYE
                     YDAAGNLTAEHDFDGRTLTYQHDAAGELVARTNGAGETTSFLRDPLGQVLERRSGGSVA
                     SFRYDALGRLLEATNDDAQVRFERDSLGRVLAESVNGRRLSSTYDALGRRTRRLTPSGA
                     ESVWDFDEGSNPLALHTGGRTVRFSHDAAGREIRRSLGANVALTQEWDANHQLTAQAVI
                     GTTGRHNQHRAYAYRPDGYLVGIEDQIAGPRRFDLDHVGRVTAVHGSGWSERYAYDTAG
                     NITSASWPAPESESEALGEREYSGSLIRRAGKVRYEHDAQGRLVLRQQKRLSQKPATWR
                     YTWDADDRLTRVATPEGSHWRYRYDALGRRTAKQRLAADGSIAEQVTFAWDGAQLAEQS
                     HTHEGAEDPNAANASVTVWDYEPGTFRPVTQRERGSLREASQEIIDERFHLIVADLVGA
                     PAELVDDDGTVAWHSRMTTWGTVPGRREHDAATPLRFPGQYHDEESGLYYNYHRHYSPE
                     TGHYASADPLGLGPAPNPTSYVDNPFRLSDPVGLSPYQSGQAAGRDPEFPSISKDNYRG
                     RFNAWLNKNGFQRLPKDWDAHHAVPQEYRNHPEFHDFDFDAPSNMRGIPGSRMGSRGAN
                     VHQEITNQWKWFHDLNPNPTRAEIEDVTSQIDRGYGEYFWAEPK"
     misc_feature    complement(16347..16349)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(19548..19550)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20696..22495)
                     /locus_tag="INP57_RS26850"
                     /old_locus_tag="INP57_26860"
     CDS             complement(20696..22495)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS26850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_26860"
                     /product="hypothetical protein"
                     /protein_id="WP_200073143.1"
                     /transl_table=11
                     /translation="MIEDELVPHGQLFGDFRGWTPNVPGAEITAVVASWCRALGADPGG
                     DPGQVRAVYREATLQRQLLVVADNLDAGHREEAAEIGLPHPEGITIVTSRDRGVGGHRA
                     DDDSVLRVHLGPLESEACVRVLVRRSGLSPDHVAPLAGASGGVPLVLAGVGAALARHNG
                     LNEPALRATITSMADDLLHPADPLWATIHASYTSLPPDVQRAWRWAAQLGPTVPLPTAA
                     ALLGLRQAEARRLLDAAVDASLLNPSGAGYHFLDLHLAWARTEPAEDEPDGLTAGVGRA
                     LAWLAASFAAAGDVLAPGRQIAPQIPAPEFEVSLPTTDRTALLAWCDHLWTVWSIHVRT
                     ALRRGEHTWAWRLLGAVLDYALLRKQWSLWDQLAAEVARELPETDHHGQGWAAHVRATI
                     CGELGAVEQAITFAEVAVEHRRQVADDAGLGWSLLTLARWLVVSGADAAHADAVLSEAI
                     AAHQRAEVPNGPTLAWVFRAGGRLAAGDLEGCDQALEHAENALPDHEVDPTLLAAFHET
                     RGRLRTQQRRYEEAEAALTAGHQIAENASDEWSLIGILDAAAHLAHARGEHDLAGDSWQ
                     QAAALADHLHDPRAVELSEHIDK"
     misc_feature    22482..22495
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     gene            23013..23276
                     /locus_tag="INP57_RS26855"
                     /old_locus_tag="INP57_26865"
     CDS             23013..23276
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS26855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_26865"
                     /product="hypothetical protein"
                     /protein_id="WP_200073144.1"
                     /transl_table=11
                     /translation="MDTAIDTPAGHRPAKTPPLGFLLAWEAGSDTAAVSPVQRDGALGY
                     PRFVVLGKATLHRLSDHATSTPVGVLRLHLRSAPTALEVVTP"
     gene            23273..23638
                     /locus_tag="INP57_RS26860"
                     /old_locus_tag="INP57_26870"
     CDS             23273..23638
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS26860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_26870"
                     /product="hypothetical protein"
                     /protein_id="WP_200073145.1"
                     /transl_table=11
                     /translation="MSTTTRRVRTTFLGGAAFVAALLMAAAGPPASGDTFGCVATLDLP
                     DEAVRADNQCPSTEIWVGIDRFGVDGPCVPIRGVFTGDSRYGTHVIWNRQQANGGHARD
                     VYECPPPGAERAIARHP"
     misc_feature    complement(23781..23794)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.73"
                     /tool="antismash"
     gene            23806..24468
                     /locus_tag="INP57_RS26865"
                     /old_locus_tag="INP57_26875"
     CDS             23806..24468
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013180.5"
                     /locus_tag="INP57_RS26865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26875"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_200073146.1"
                     /transl_table=11
                     /translation="MSQDVAWPTFPLGLLGFENYELRRQIEFWRDYTAELERELARVSS
                     QAWDTVAEVPLRAVWESIVDARLAEEPDRTAVVWADLDQFKQLNDRYGHLAGDAVLREV
                     ARRLEEAFAAHAPVVTRLGGDEFGVVVRDLDPEADLARFAALMDEPVLLPHGRSVRVAA
                     SVGFARASELVPGASRDELLRRADAGAYAHKSHHLPGAPSPRSRKRVAATDVLGAVQ"
     gene            24496..24684
                     /locus_tag="INP57_RS26870"
                     /old_locus_tag="INP57_26880"
     CDS             24496..24684
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS26870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_26880"
                     /product="hypothetical protein"
                     /protein_id="WP_200073147.1"
                     /transl_table=11
                     /translation="MGTMLCGLVAAPLVTIGLMPWLPRWTWWMPGLVGGGLAVLSAAVQ
                     ARFGSDPVWAAWWWLAV"
     gene            complement(24673..>24798)
                     /locus_tag="INP57_RS26875"
                     /old_locus_tag="INP57_26885"
                     /pseudo=""
     CDS             complement(24673..>24798)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_050768036.1"
                     /locus_tag="INP57_RS26875"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_26885"
                     /product="IS481 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="TAALAVWNVHYNYHRPHTAAGDQPPASRLSTGVTNVMASYS"
ORIGIN
        1 gacaccctcc gccgcaatct cagcatcggc tcaaaacgag cccgcaccgt cactcacccc
       61 atccgcccaa caccgccagc cgactgcagc gctgccctac agggccgacg ccaccagcgc
      121 caggggctgg gacggcgcca ggcggagacg acgtcgcgac cctcgtcagc cctggagggc
      181 cgacgccaca ccgccccgcc aggccgaaac cacggtcgtc actccagttg cgagacataa
      241 gtcgggaaag tcggtgaagt tacgaccctc tcgtaggggc gatgaacacc cgagatccag
      301 ggtttccgcg cgacgccacg tgttgcgcca ccactcgtcg cgcacgtcga tcacgcacca
      361 tcggcagcac cgaccgccag cacgttccca cctcagcgta gcgaccaaag atcacccatc
      421 agcgtgacca ggaaatcctc ccatcacgcg accccatttc gccccagcac tgatcgatcc
      481 tcccaaattc ctcccaaaaa tcggagcaga ccgaccacga agatcaacta cgagatcacc
      541 accgcaacat caaaaagccc gctgacctgc gcatttgcgc tagatcagcg ggcttccgcg
      601 accgtcggga cggcgggatt cgaacccacg accccctgac ccccagtggc gcccgtcaac
      661 tcacgtgacc tgcgaagaca gagaaactgc tggtgcgacg gtgtcgttcg ctactgttga
      721 ggtttatcca gcaacgttca agaccgcacg ttcctcccaa tttcctccca cgcgccgatg
      781 tcaaaaatcg ttcgtgctga cgagcaacgc acttacatac tgttataatc cacaacagac
      841 ttatccgggg ccagcgagaa ccgcccctca cggcgcggtt cccacaagat acctggtatc
      901 cgtgccgact ttccagcagc cgggggtcta gtcggtaaag gtcgccgact tcgagaagtc
      961 cagcgacgcg acggttatca cgtgcttgga tccctgtcca gtatatgcca ccggcacttt
     1021 caccgtctgc cccggaccga gcggcggagc ggacaacaac ccattgaatc cattctttcc
     1081 atcgaaaatc tcctcagccg cccggctgtc cacggtcgcc ccaatgttca gcaccgccaa
     1141 tggaaacgcc cggtcggtgc gattggtgaa ctcaaactca actccccacg ccggaacacc
     1201 accctgcgga gcggcgaact ccgacgtgtt gaactggaac ggatccagct tccgcaccgt
     1261 agtatcaatc tcaccttcgt acgtttgacc aaactggaac gtattcggct gccggtcagc
     1321 ctgcccagcc gggttcggta ccgccgccgt atccggcgtg accggcccag tcggccccac
     1381 accgtcctgc accccacacc cagacaacac accgaccgat agcgccaggc ctccggcaac
     1441 cgaccacaac tgtgtcactg cgtgacacct ccattactca acggattcga ccgaagaaca
     1501 atacacacac agggccaacg tggggccaat ccactacatg tcactcgaaa cgacgcgttc
     1561 cgaccgcagc taccacccca tccgctcaag gacagattta agggaccagg cacgctcgca
     1621 cccgacttag ctatcacctg cagcaacaaa gccagcgcaa cacctgccgc gggtgctgcc
     1681 gcccatgcac ctagcgctga cacagccacc gccccacgac cgccgagtgc ggccggaaac
     1741 ttgcgacggc ctcgctactc acacgaggtg atccgcggat acgctcccct agccacaaga
     1801 gcctgagcgg ctgcgtatca acgcgggtcg atcagcgtga ggtgttcgaa gaacgatgta
     1861 ctcaagctgt ccaggatggc tcgtcctttg gccgcggttg cttcggaggg acggccgatg
     1921 acgccgctgg ggctgtagtg ctcgactccg agggtcaaca gatgcggccg gtcgtcggcc
     1981 tggtgatcgg cgcggtagta gctctcgccg acgaggtgcg ggtgcgcgtg cagcagcagc
     2041 gaggtttcga gttcaccggc gtgcatgtcc tcgtgggacg aggtgaccgc gccggcgtgc
     2101 tcgcgggcgc ggttcatgtc gcccccgcca ggaaacagaa ccacgcaccg ttcgtcggta
     2161 ttggcttgct gggtgatgtt ggagaggacg tagtttccgc cgtgcccgtt gaccaggacc
     2221 agtttggtga tgtccgaacg gcgcaaggaa acgcggatgt cctcgatcat cgcgaccagc
     2281 gttgtggcgc tgacgctgac cgttccgggg aaggagtcgt gttcgtgcga gcacgacacg
     2341 gtgatcggcg gtagcaggaa gagatcgtag tcctcggcga tccgttgggc gatcaggcac
     2401 gcgatgacgg tgtcggtggt cagcggaagg tgctcgccgt gctgctcgaa gctgccgacg
     2461 ggaagcacgg cgacacgtgc ctttcgggcc gcttcatcgg cggaagtggc agtggtgagc
     2521 acgtccacga ctctcctcaa cttgctcgca gcgtcacgcc aatgtcgtcc gcagcgtacg
     2581 gctcaactgg gacgcctgat cgtgcgcgcc cgcgtccgcc aacagctgcg acgttcgacg
     2641 gagctgccgt gccgtgcggt gggaccgcgt ttcggtcgcg atcgtgagcg aatgccgcgc
     2701 cacggcgacc gcttcttccg gttggtcggc gacggcatgg gcaacggcca atcgcgcaag
     2761 cccgagcccg aggtcccgcc ggaagtccgc gtgccagttc gcgatgccct gctggagcgt
     2821 ggccagtgct ttgaccggtt tgccgagttc gacccagcag tgcgcggctt ccatctcgac
     2881 atagctcggc gtgcaatacc gcgcgatgtc gctctcgtcg tcgggctcgt cggccgcgta
     2941 tcgaaacgct cggtcgatgg cgcgcgaaca tccctcgtag tcgccggcca tggcgtgccc
     3001 gtgcgcttcc tgccgcagcg caaccgcctt gaggcgcggg ctcaacgtct ccgaggaccg
     3061 cagggcagcc tgagcgaagt cgatcgtcaa agcaggcttg tgcgcgtcgc ttgcgatatt
     3121 gctcttgcgc atgtggatgt aggaagccag gtgtgcgtcc tcggcctcgt gcgcgagatc
     3181 gagcgccgtg ttcgaccacg ccatcgcttc ctgcaacttg cccgcgtctt ggtccagcca
     3241 tcccgtgaac tcggcgaacc gcgcggcgac gtacaacagc gaccggtggc tttgcccttg
     3301 gctctgcgcg agcagtccgt tggcgaagct cgcttgctta gcggcgaccg gaagcaccga
     3361 acgcggaccg acgaggttgt cggtggtgat gtactgcttg agcgtcatca gcaacgactc
     3421 ggccaacgct ggctcggtac gcacgttcgc agcgggaacc gatgggcctc ccggcagaac
     3481 taccgcagcg tgtttcggtg gcaccggttc gtcagcgcta tcgcccgcgt cgaaccacag
     3541 cagttcaggc gggatgcgca gctgccgggc gtaatgccgg agctgatcca gctcgcgcac
     3601 ccggttccgc ccggactcaa tcctgctgag ctggctttgg gtgatgctca gccacttggc
     3661 cacatcggct tggggcaacg gtttccggcc atgcgcggga tgaacgcggt aggcccgcac
     3721 gacagctccc atgtccttgc cggcaagcgc ttggcgtagc cggtcttcgg cccagaactc
     3781 gtcgccgacg cgcgggcctg cctcctgatg attcttggga gcgcgccgac acggcgagca
     3841 gacgggcgcg gcgttgtccc gggcaagttt gctgccgcat ctcgcacagt ggcgcgatgt
     3901 ttctgagcgg ccggcttctg acctcatcaa gatcgctccc agtcgattcg ggtagccatc
     3961 gtatctgcta gggccagcca gtatgcgcgg tacgcatatt tttcatgcgc gatccgggca
     4021 atcgtgccgg ctgtgcggcc atagcttcta catacgccag caccaacgac gtgaggaggt
     4081 gtcttcgaat gcatggacga ctcactgtgg cagtttcctc agcgcgaccg gaacaagttt
     4141 cccgtagcgg tcgtaccgcc aagcgaacgg cccgcctgta ctggttttgc gctcgtggag
     4201 atccgcagcg acgtcacgct acgcaggaaa gcctctcggc tctgcctgtc aactccgcgg
     4261 tcaagacctt gtgcgggtac gcggcgacgg tgccgttgcc gacgccgaac gaccgggttc
     4321 cgaagagccg ggtggtcacg gcgcgatgtg gcgcatgtgt gaaggcagcg gaatcgctcg
     4381 gggcccgtga ggtcgtctgg gattcgtgat cgtccggtgc ccgcttgatg tggcgcgggc
     4441 gctgggtcga gggccgtgcg gtgcggatga agccccccgc ttccgcaccg cgcggtccgc
     4501 aatttcccac cgagaaacga agaagcgcag gacgcccagt tcccgtccaa cccactcaac
     4561 gagcactcac catccaggca cggactcaag gagttctgat gatccaacag cacacgtcgg
     4621 ccccgccgaa gaccggtgac gtggtcgagc ttggaaaaca gatccacgac cggttgggcg
     4681 aagtcctgtt cgcacttccg ggccgcagca ccgtcaccta cgaagaactc ggcgatcttg
     4741 gcgcccggtt gcgcggcctc gccaagatct tcgaccggta cgcgcccacc cgcccgatgg
     4801 ctgagcgccc cggctcggcc acagctccac aggagaacgc gcgagtctgg gttttcccgg
     4861 gccagcagcg ataaccgact cccggcaaga gcgtgccgtg ctccccgaca cgagcgctcc
     4921 ggccgggcgt ggtctgtgcc gccaggacat ccctccaccg gcggcacaga ccacaacccc
     4981 aaggcgcaga gcaggaatcg acatcggcag cgccccgcat cgctgccggt ccggatcccg
     5041 tgccgcgccc gagccggttt ccgccccgaa agagaaccgg ctggcaatgc gggggctcga
     5101 tcaccacgcc cgccccgagc ggatctcgcc gcggctcgat ccgcgtgtgg tgatcgagtc
     5161 cccaggcaga cgcgtgctcg tattccgcac gcaccccagg ccactcattg cggaaagtct
     5221 cgaccttgtc agcatcctga cttggctcga ccgcctacga ctgccgcgcc gaatatgcct
     5281 accaatccgt gccgaagctc ctacgcaacg gcacaccgtc ctatcaggag agttgtgcat
     5341 gaaccgtgga atcagtgtgg tgtcgctgag cgtcggcagg ctgctagggc acacgtacgg
     5401 gcagagcctc ggcgatgcat tggccacggc atcaccgaag gacccggcca ccgtcgccgc
     5461 ggtcgtgcgc acccacctgc acaccgccac cgcgatcagc gacgagctga tccgccaagt
     5521 cgcggccgac ctcgcgcttc ctcccgggca gctcgccgat ctgctgcaca caccacggcc
     5581 actgctgttg aatccgaccg cgcgggcgct gatcgcagga ctccgcgacg catgtcccga
     5641 catccgagtc gtggtctgct ccaacctcgc ctccgccgac cacgtccacg cgaacgcggt
     5701 gcgcgatgaa ctcggaccgc tgctggacgc ggcctacttc tcctgcgaga ccggcctggc
     5761 caaaggcaac ggccctgcca tgttcgagca cctcgctcgg aaccatagcg tcgaaatcgg
     5821 cgagatcgtt cacgtcggcg acacgctcct ggaagatgtc caggcaccgc tgctggccgg
     5881 agcacgtgcc ttgtgggttc acgccgacca tgcgcgcact ccccgcgtcg ccggaccgga
     5941 tcgctaccgt gctgttcccg acctggccga ggcgatccgc gaacttcgtg aatggatacc
     6001 ggaaagccaa cctcgtcccg cgttaccggt ccgcgccgca gcactgatcc gcgatgtcca
     6061 acaacgcatc ttgctggtac gcggtcccga cgacgaagac ttctcgctgc ccggcggccg
     6121 gtgcgaggcc accggatccg actcgccgcc caccgcgatg gcccgcgaag tccacgaaga
     6181 acttcggctg gcggtcacgc ccggcaagct agtgtgggct ggctggtccg aagccgaatc
     6241 cgccaccggt gaaaacaaga tccacttctt gttcgaggcg cacatcgtgg ggaccagcgt
     6301 cccggttccg gacgccagcg aggtcgccga gatccgctgg tctggccacc acgaggcgct
     6361 gcgcctgctg catcccgccg aagccgaccg gctgcaccgc atcggttgcg accgcagcca
     6421 cggatggcag tacgacacca cccggccacc acgggctcag ggcccctagg tcttggtgcc
     6481 ttacgaagaa gctgcaccgg atcgcctgcg gagttccgtg gagctctggg ccaacagggt
     6541 ttcgagctgt gcgccagtga tggcggcatc gtggagctgc gcgaagaagt cctcgtaggc
     6601 gcgaacgtcg tcgggcgaat cgagacgctg ctgtgcggtg agggactcga tgaggacgtg
     6661 gtcgtcgtag agcaggaagt tcgtcagcgg aaacacgggc atggccgcgg tgaacggcac
     6721 gacgccgatg tcgacctgcg agtagccgag cagggcgagc agccggtcca gctgacccgc
     6781 gagggtccga gggtctccga aatgggtgtg cagggcggcc tcacccatga tgatccggat
     6841 cggttcctgc cggggctggt agaggacttg ctgccgttcc atgcgtttgc cgacgatctg
     6901 gtcgatttcc tcgtcggcta ctccggcgga agctgggccg caggggcggg tgagaacttc
     6961 acgcgcgtag gcggcagtct ggagcagtcc gggcatcatc gcgggctgga actccgcgat
     7021 gcgcgcggag gcggcatctt cgttcgtggt cgcctgctgc tcggcgacag caccgccgtg
     7081 ctggcggtag cgctggccga aggtggcgta ctcgatgcgg gccgcctcgg cgagttcgaa
     7141 gagctcgtcc agttgctcgg cggtggcatc gacagcctcg ccccaccggc gaaggtcgtc
     7201 gtcggtggga cgctgactgc cttgctcgag cttcgacacc cgcgtctggt gccagtccag
     7261 atgacgcgcc aaggcgctgc cggaggcaaa cgcggtcgcg cgcagctcgc gaagacgtcg
     7321 agcgagcagt gctcgctgcg gcgtgttcgg gcccggcacg ctggttccct tcttctaacg
     7381 cgagtcgtac tcgctccacg atattgactg cgcaatcgcg gcctcgcgct gggcgcacgc
     7441 atcggcgatg cactgcggat cggtggtcgg ctcggcgccg agccacgcgc cgtccgggga
     7501 gtagcgcatg gtccacagcc tgcgtgcgtc gatgagccag tagtcggcgg cgtgcacgtc
     7561 ggtcggccat tgatctccgc ggacgggaat gatccggacg tcctcccccg cttgaacgtt
     7621 gggggcgtac gaggccagtt cgaaccgtac gtagtcggtc agcggttcgg tcactacgtg
     7681 cacgcgctgg agccggcagc cctggccgac gcggtgacgg gtgcgttcgc accactgctg
     7741 gagttccgcg gtgaccggga tgcggccggt gcgtcgccac tcggcaaagg cgtcgtcctc
     7801 gctgctaccg gagtagttct gcaacgtctc cagacgaaac agcgaatagc ggaaggcggc
     7861 aagctcgtga cgaagctggt cgatgccctc gcgcaggtct tgcgcgggcg tcacagggcc
     7921 ttctcctggt aaaggcgggc gacctcgacg aggatctcgg gcttgatcag gacacccgac
     7981 tcgcccggga gcagattttc catgttggcg aaggtctccg ggtccatctc gaggccctgg
     8041 acggccatca tgccgttctc ggcgaggtag acgctctggc agccggtggg gttcgactcc
     8101 gggtccttgc agatcttgtg caggtgcacg acggcctccc gtctcgtcgg ggcgcgaacg
     8161 ccacgatctt cgcttagaac gaccttgact gtccataacc ttgctgacaa cctcattcta
     8221 accgcgttct aaccttgatc gtcgttaggc ggtgttcccg atagccgtcg gcggcttccc
     8281 ctccctgccc accagggcgc aacgacagct ggcgttcagg gagcacacgc gcgtgcggcg
     8341 aacagcggga agatcatcga gagaaaggca ggaagcccgg tgagcacatc ttccgaacag
     8401 gacccggacg actcgctgga accggcggcg agccctgcca ccggggcgac cccgattcag
     8461 ccgccgcggg cggcgatggt gcagcggttg tggaagctca acgcgctgcg ttcggaacgt
     8521 gtcgcggagg tcttcgccac ggtcgacagg cacgtgttcg caccgagtgt gccggcggaa
     8581 gaggtctacg acgctacgac cgcagttcgg acgaagtggg acgagcacgg cagcgcgatc
     8641 agctcgatct ccgctccgca gatccaggcg ttcatgttgg aacaagcgga tgtccggccg
     8701 gggatgcgcg tgttggaggt cggctcgggc ggcgtcaacg ccgccatgct ggccgaactc
     8761 gtcggcgaca cgggcaccgt gaccacaatg gacattgatc cggagatcac cggccgagcc
     8821 cggaaactgt tggatgcggc gggatacccg caggtgcacg tggagtgcgc ggacgccgag
     8881 catggcgtgc ccgcacgagc accttttgat gtggcgctgg tgacggtcgg ctgctgggac
     8941 cttcctgccg cgttgatgga ccagcttgcc gagagcggac gcgtcgtcgt tccgctgcgg
     9001 atgcggggga ttacgcggtc cctgtcgttg cgtcgcgccg gtgaccactt gctggcggat
     9061 tcggccgagg tgtgcgggtt cgtcaaggca caaggtcttg gcgcgcacca ggaaagaatg
     9121 ttgctgctgc acggcgaccg gatcgctctg cgcttcgatg acggcaccgc accggccgat
     9181 tcggcccggc tggacggcgc gttgggtacc gaccgcgttg acgtgtggtc cggcatcacc
     9241 gtggaagcga tggagccgtt cgacagcttg gggctgtggc tggcttcggt gttgccgggc
     9301 tcgtgccgga tcgcggtcga tcccgactac gacccggaca ccgacagcgg tccggcgatg
     9361 gtcgtccccg aaggccgctg gttcccagac gcctacgtca actcgcacga ggactcgttc
     9421 gcctacctcg ctacccggcg cctcgacgac gggctcttcg agttcggcgc ccacgccttc
     9481 ggcccgcacg ccggagaggc cgccgaggcg atggtggagc agatccgcgc gtgggaccgc
     9541 gactatcgcc acggccctga cccgagcgtc gccgtctggc cgtacgacgc cccggacgag
     9601 gcgctggagt ccccggatgc cgctgcgacg acggtgatcc cgaagcggca caccaccatc
     9661 acgatctcct ggccgcaccc ttcggcgtag caaccgagtc ggccaggttc gttggaacgg
     9721 aacgataagg aaggaaacgc atggcggcca acacgaccac gctgtcccgc accgaggacg
     9781 tcgacatcag cgacgatttc acgctcgact tccaggtgat cgagtccgcg tacccgctcg
     9841 cgaagttgag ttgcgacacc gatgacgggt gcgggcagac ctgctccacc agcgcctgca
     9901 acagccaggc caacaacccg tcgtgaaccc tgccctcgcc gggacgccga atccccgtgg
     9961 cgccccggcg gggacgctct gtccgatcca ggaggtttgc gtggccacgc cgtgcctttt
    10021 tcgtcacgcc gagttcgtac tggttcgagc gagcaccgac ccgggaggac tgagcctgcc
    10081 gcggctggat ctgcacactg ccgaggacgc cgagacgacc ggccgggaat ggctcaccga
    10141 gttatggggc cgcgatgtcg tacgcaccgc cttcggtgtc gccagcccag cactgtgcga
    10201 gcagatcgcc gccgcagtcg acggcgcgaa actcaaccgc cgatcctggc gccgcttgct
    10261 ggtctcgacg tgctcctacg tcctgcgctg gcagcagcgc cccactccct tcggcctgtt
    10321 cgccggagtg accaccgcag ctattggcgg gtccacgcac gtcgtcttcg gcgagcagca
    10381 tcagccgcac cggcagatcg acccgaactg gctccacaag ttgatcagcg agctcgaatc
    10441 cgatcccgag gcgctggcga aagcatcgct cgtggtcaac aacgcgggca ccgtccgcgg
    10501 cgaccgattc gtcgtcccca accatttgtc cggtaccgct gatgaaaaat cctcggcgca
    10561 ggtggccgct gggctcgatg aggtcgaact ggcgctgcgt cgcacacgcc cggtcgatgc
    10621 cgcacttgct gcagcgcggg ttccgatccc gggacgaatg ctgatcgacc gactgcaccg
    10681 tgaattcccg tcggttccgc gtgagcaggt cacgactctg attagcggac ttgtcgcgca
    10741 ccgcgtgctc gtgaccagcc tccgggctcc cgcgtcctac ccgaagcccg ccgaacatgt
    10801 tctcgcgcag ctggacgatt cccaccgcga cagcgacgag aacgaccgtg tcggcgatgc
    10861 tcgcgaggct ctgcgctcct tcttcagctc gggctcgcag gcgaaatcca ccgtgtccga
    10921 agccacgagc tcggctcgct cgacacctcc gaccagtgtg gacgtctcgc tggacggacg
    10981 gatcacgctt ccggagcccg tgctgtgcga agccgagtcg gcggcctccg tcctgctcga
    11041 ggtgagtccg agcccgttcg gcactgcacc gcggcgcgac taccacctgc ggttccgaga
    11101 acggtacggc tccggtgcgc tggtcccggt acgcgagttg gtgtccgact ccgggctcgg
    11161 tttcccaacc ggtttcctcg gcgcggcccg cgaacaaggg gctcgcttcc tgaccgatcg
    11221 cgacgccgcc ctgcaagcga tgctgcagga gaccgtcctc gatggacgga ccgaactcgc
    11281 cttgtccgag gaactgatcg agcaactctc cgtcggagac caccgcgatc tgacgcctcc
    11341 tgaacgcgtc gagctggcgt tcacgatcca cacaacctcg accgaggccc tggaccaggg
    11401 acggtttcag ctgtgggtca ccggggctcc ggtgccgacc tccagcatgg ccgggcgctt
    11461 cgccagcgtg ctcgacgagc acgcgcggca acggctgtcc cgcacctatc cccaagggga
    11521 cgaggtgatg gtcgcccaac tgtcttttgc cccgcggcgc atcgccaatg aagccgtcac
    11581 ccgcactccg gacctgttgc cgtggctgtt gcccatcggc gagcacccgc cggagctcgg
    11641 cgccgactca gctcggttac ttcatctcga cgacctcgcg gtgaccgcca gctccaccca
    11701 gttcttcctc atccaccgcc ccagcggaaa gcctgtgcac ccctacgtgc cacacgcctt
    11761 ggaaaccacc gtctacacgc caccactggt gcgtttcctc gccgaactgc ccaccgcgcg
    11821 gcgggcggtg ttcggcccca tcgacttcgg cgcgagccgc accctgcgat tcctgccccg
    11881 catccgacac ggccgcagcg tgttgtcccc ggcgcggtgg ttgctacacg tcaccgatct
    11941 ccccggcgca cgcgccgcga gcagtgaatg ggagcaagcc ttgaaaaggt ggcgcgagcg
    12001 ctggcgagtt cccgcccacg tgctcctcgt cgaaggagaa caacgcctcc cgctcgacct
    12061 cgacgaaccg acccagcgca gcctgctgcg cgtgcgcctg aaccgagcag gcaaggcgga
    12121 gcttcgcgaa gcaggcgatc ccgcacgacg cggctggacg ggacgcgcgt gcgaattcct
    12181 ggtccccctc accgctagcc cgatcccgcc cgcgccgccg gtcagccgga aagtcgtcgt
    12241 ccgcgatgac agcgtcggct cgcccgcccg aaacgacggc gccttcccgg gcacttcatc
    12301 gctcgtcttg tccacattgg aaggacatcc gcagcggttc gacaccatcc tggccgacca
    12361 tctcccgaac ctgcaccagc acctcgacaa cgagatccaa cgcctgtggt tccgccgcca
    12421 ccacgacacc acccgacctg actcggacca ctcgctacag ctatggctga ggctgaccag
    12481 cgccgaccgc tacggatccg ctacgacatg cctggccgaa tgggccgaag acctgcgcgc
    12541 gtccggactg ctggcccaag tcagcttcga gaccgcctgg gcacaacccg gcaagtacgg
    12601 cgacctgtcc gccgccgagt gggtgttcgc gaccgattcc gcagccgcac ttgccgagat
    12661 ctcctgtgcc gaacagcttc agcttgctcg agctgcggtg gctgcggtgt cgatggttga
    12721 tctcgccaca gccctcgcat cggacgcgaa gaagggctgg gagatggtga tcgccagcct
    12781 cccgcagcag accggcccgc tcgacgctgt tctgcgcgag aacgccctcc gctttgcacg
    12841 cgacctacga caggatcagc cagccgcccg cgacgatgta ctgcgcgcgg catgggccga
    12901 gcgtcgcgaa gcgctcgaaa cgtaccgagc gcagctcgac cgtccgccgg aatcagtcct
    12961 ccgagcgctg ttgcacgaac atttccggag gaccatcgcg gtttcccgcg aacaggagga
    13021 gatcaccaac cggctcgccc gcgccgtcgc gttgcaggcg ctcgcgctga cccaacgagg
    13081 tgttgaatga accggcacca cttcgccgcg cccggcacca cgaagcacgc cgaactcctc
    13141 agcgttctgg caacgcccct gaccgaaccc gacgccgggc agcccgagct ggcccaatcg
    13201 ttgtcccgcg gagccgccgg catcgccctc tggcacctcg aacgcgccca ccacgatgtc
    13261 cccgaaacac ggcctctgct gcaccagtgg gtgcgcgccg cgctagcttc gccgatcagt
    13321 tcagccgaaa ctgcgggcct gcacgcaggt ctgcccgcga tcacgttcct actgcacctt
    13381 gccgagcccg tactgcccga atatcgcccg gccatcaccg agttcgacca gcacctgaga
    13441 cggctcgccc accgccgggt cgacgccgcg ctggaacgca tccggcacgg ccttccgact
    13501 cgtttcgccg agtacgacct gatgcgcggg ctgaccggga tcgggcacct gctgctgcac
    13561 catcaaccag gctccgatgc cctggcccgg gtactggact acctcgtgcg gctgaccaaa
    13621 ccgatcaccg ccgacgggac gacactgccg ggatggtggg tcgaccacgc acccgaccag
    13681 ctgctgccga caccgggcgg gcacagcaac ctcggcattg cccacggcat caccggcccc
    13741 ctcgccgtgc tcgcccacgc ggcacggcgc gcgatcaccg tcgatggcca atacgacgcg
    13801 atcgagcgga tctgcgcgca cctcgaccac tggcagcagg acagcaacgc cggaccctgg
    13861 tggccgtatt ggatcgacca ccacgactac gtcctcgggc gcctcaccaa ccaccagccg
    13921 ggacggccat cgtggtgcta cggcacccca gggatcgccc gagcacaaca agtcgcagga
    13981 ctcgccaccg gcgataccac tcggcaacac gtcgcggagg aagcactgct ggcctgcctc
    14041 aacgacgcca gccaaactga cctgatcagc gacatcggcc tatgtcacgg atgggccggg
    14101 ctgtacctca cggcagctcg aactgcccac gaagcagcca ccccggacct cgccgcaatg
    14161 ctgccttccc tcgcacagca actcgtccga cacaacgaag ccactccgcc tcccgaactc
    14221 ggcttgctca acggcgctac cggcgtcgcc ctcacccttc acgccgccag aacgggcatc
    14281 ccgacatccg gatgggaaca atgcctcctg atcagctgaa caccgcggca gcgccggccg
    14341 agctcatcgc cacggccatc cgcagcgtga cggcaggcga aatcctcacc gaagccgccg
    14401 cagcccacga cctcgatgtc ggcgagctcg ctgacgcact cgacacctac gaccgggccg
    14461 gacgcgccgc cgtgtacgac cgcgcggcag atgcgacttg gtggcaagca catctcgaat
    14521 tcagcgcatg ggaccaagcc gaactcgtcg cagcctcagc cctcgcacca ctcctgaacg
    14581 cttggagccg gaccggcctc ctccggcaat ggtggttcat ccggaaagca ccgagctggc
    14641 gcctccgcct gcaacccgac accgaccacg atgcgctgca cacccacgcc accaccgagc
    14701 tcgaccgcct tgtccaacac ggccacctcg ccagctggcg cccgagccac tacgaacccg
    14761 aagccctcgc attcggaggc cccaccggaa tccgcatcgc acacaccctg ttcagcgccg
    14821 acagcgccaa cctcctcgcc cacctccaca cccgacacgt gccgctcggc cgcattgaac
    14881 tctcgatgct gctgtgcacc cagctcttcc gcgccgcggg acaagaacag ttcgaggccg
    14941 ccgacatctg gcaccgcgtc acctacctgc ggccgcaccc gcagcacacc agcaccgaca
    15001 ccggacacca caccgacttg acccagcagc tacgcacgat gctgacctac gctcgaccca
    15061 ccggaccgct cttcgccccc gaaggccccc tccacgcagc ccacgactgg gcacacgcct
    15121 tccaccaagc cggacgtgac ctcgcccgcg cagcacaaga atccaagctg cacaggggaa
    15181 tccgacacat cctcgcccac cacgtgatct tccactggaa ccggctcggc ctcgacacca
    15241 acacccagca cgcactcgcc cacgccgcga cctgtgcact gctcccgctt gagaccacgc
    15301 tttgaactgg acctgcagtg gcaactccgc aaaacggctc gtcccgctac cgcgatttgt
    15361 ctgagacgag cgacgacgca gcagcaccaa gaacgcccac tccgagagtg ccctccagaa
    15421 cgacgtcggg ccggagaagc tatgcgtcgt gcagtgcttc gcgtaccttc tggtgaatac
    15481 tctctaggag gattgtaagg tcgttcgcga tcacgtcgac gccaccggat tcgacctcgt
    15541 atgtggaacc gacgagagcg ccgccttgga ggaggtagat ccttccatct gatcgactca
    15601 gggcgaacag ccctccacca ccgtcggatc cgatgacgat gatcgagtcc tcgacagcgc
    15661 ccgtgacgcg ggtgggttga ccgtctttcg caccgtcgac aacagccgtg gccgattcga
    15721 tgaacaggcc gttctgcacg tcgggaagtg acacttcgtg aacttccgag tagaattcga
    15781 gcaggcccga gggagcaccc atcgacgaaa gttcggcgat ggcttcgctt tcaccgcctt
    15841 cttccgacct ggtcaccaca ttgtcgtcgg gagggtatcc gaatgtgtcc tcgaatccgc
    15901 gcatgagttc gtcgaggtct tgcgacatcg actggatcca gctatttagg ctctgcccag
    15961 aaatattcac cgtagcccct atcgatctgg ctcgttacgt cttcgatctc agctcgcgtg
    16021 gggttcgggt tgagatcgtg gaaccacttc cactggttcg tgatttcctg gtggacgttg
    16081 gccccgcgag atcccatcct actaccgggg atcccgcgca tgttggacgg cgcgtcgaag
    16141 tcgaagtcgt ggaactccgg gtggttccgg tactcctgcg gcaccgcgtg gtgggcgtcc
    16201 cagtccttcg ggagtcgctg gaatccgttc ttgttcagcc aggcgttgaa tctgccacgg
    16261 tagttgtcct tgctgatgga ggggaattcg gggtcgcgtc ctgccgcctg gccgctctgg
    16321 tagggcgaga gccctaccgg gtccgataac cggaaggggt tgtcgacgta cgaggtcggg
    16381 ttcggcgccg gtcccagtcc aagcgggtcc gcggatgcgt agtgtcctgt ttcgggcgag
    16441 taatgccggt gatagttgta gtagagtcca ctttcctcat cgtggtactg gccggggaag
    16501 cgcagcggcg tagcggcgtc gtgttcccgt cgaccgggca ccgtgcccca cgttgtcatt
    16561 cggctatgcc aagcgaccgt gccgtcatca tcgaccagct ccgcgggggc gcccacgaga
    16621 tcggcgacaa tcaggtggaa gcgctcgtcg atgatttctt gggatgcctc gcggagagat
    16681 ccgcgttctc gttgggtgac cgggcggaac gttcctggtt cgtagtccca caccgtcacc
    16741 gaagcattgg cggcattcgg gtcttccgcg ccttcatgag tgtgggattg ctctgcgagt
    16801 tgggcgccgt cccaggcgaa cgtgacctgc tcggcgatcg agccgtccgc ggcgaggcgt
    16861 tgcttggcgg tgcgtcgccc caaggcgtcg tagcgatagc gccagtggga tccctccggt
    16921 gtggccacac gcgtaagccg gtcatcggcg tcccaggtgt agcgccatgt ggcgggcttc
    16981 tgcgacaggc gcttctgctg ccgcaacacc agccgacctt gcgcgtcgtg ttcgtagcgg
    17041 actttgccgg ctcgccggat caggctgccg ctgtattcgc gctcgcccaa cgcctcggac
    17101 tcgctctccg gcgcaggcca cgacgcactg gtgatgttgc ccgctgtgtc gtaggcgtag
    17161 cgttcactcc acccggaacc gtgcacagcg gtgactcgtc cgacgtggtc gaggtcgaag
    17221 cgacgaggcc ccgcgatctg gtcctcgatg ccgaccaagt agccgtcggg gcggtaggcg
    17281 taggcacggt gctggttgtg ccttccggtc gttccgatca cggcctgtgc cgtgagctga
    17341 tggttggcgt cccattcctg ggtcagcgcc acattcgctc cgagggacct gcgaatttcc
    17401 cgccccgccg catcgtggct gaaccgcacc gtgcgtcccc cggtgtgcag cgcgagcgga
    17461 ttgcttccct cgtcgaaatc ccacacgctt tccgcgccgg acggagtgag tcgtcgggtg
    17521 cgccgtccca gcgcgtcgta ggtcgagctg agcctgcggc cgttcacgga ttcagcgagc
    17581 acacggccca gcgagtcacg ttcaaagcgc acctgtgcgt cgtcgttggt tgcttccagc
    17641 agccttccga gggcgtcata gcggaacgac gccacagatc ctccactgcg gcgttcgagg
    17701 acctggccca gcggatcacg gaggaacgag gtcgtctcgc ccgctccgtt ggtgcgtgca
    17761 acgagctcac cggcggcgtc gtgctggtag gtgagggtcc gtccgtcgaa gtcgtgctcg
    17821 gcggtgaggt tgcccgcggc gtcgtattcg tagctccaca ccaggccgcg ctggttcgtg
    17881 acgctgacga gtcggagttc ggtgtcgtaa ccgaattcca gtcgcgtgcc gtcgggacgg
    17941 acttcggccg agggcagttc gaagtgcgtg gcttcggtgc gggtggtctg accgagcggg
    18001 tcgatgtggg tgcggagatt gccctcgccg tcgtagagcc accgttcggt tgcaccgtca
    18061 ggcaggacgc gccacgcggg ttttccgtcg acggtatagc cgagccgggt cacgccgccg
    18121 accggatcga tgctggccac gacgcggccg aaaccgtccc gctcataccg ggtcgtcccg
    18181 ccggtcggcc cagtaatcgc cgtcggtagt cccgccgcgt tggtttcgac cgtactggta
    18241 tgccccaacg tgtcggtgac agcagtgaga tgaccgcgct cgttgtagcc gtaggttgtt
    18301 accgcgtcca ccgggtcgat gacccgggtg aggttgccag cgtcgtcgta ctcgtggcgt
    18361 ttgagcgtgc cgtcgggtgc ggtcatcgtg actggctgcc gcagttcgtt gtactccacg
    18421 gagatccggt tgccgtccgg tctgaggacg gtcgtgacgt tcccgttgtc gtcgtaccag
    18481 tacctcgtgg tgcgcccgag ggggtcggtg cgcgaggaaa gccgccggtg ctcgtcccat
    18541 tcggacagcg tctcgctgcc caacggggcg acctcgcgga tgattttgcc gtcatcgttg
    18601 aggtggtatt cggtctgatt gccgagggag tcgatgaggt aggtgatcga gttgtcgctg
    18661 tcgtacgcca gcgtgcagct gaggaacccg tctgcgcctt ccccgcggac gcagcggcct
    18721 tcgccgtcgt aggtgaagcg gtacgagctg ccgacgcggt ctttccaacc gatgatgcga
    18781 ccggcgtcgt cgtagtcgaa ccgcatcggt tgtccggatg cgttgatcac ctcggtgagc
    18841 cggtctcccc ggtagcggta acgcatcagc ggcacgtccg cgccgttgtc ggcgccgcac
    18901 agatacagcg cggtcacgag acggtcggtg ctctcgatcc ggatccggta gccaccgctg
    18961 tggcggacct cggtgggcag accggtgtcg tcgtggacga agtcgatgcg gtggccgttg
    19021 cggtcggtga tcgccgtgag cggccagtgc gcgtcgtgct gcgtgaagtg caggaaccgt
    19081 ccctgctcca cgtcggtgat cacgtactcg ccgtcctcgg tacggatcag cggccattgc
    19141 ggcccgacac gcgggagaac cgtgaccccg ggcatcgggt ccgggtaggc cagcgcgagg
    19201 gcgtcgtccg aggcgaaata cacgccatcg ccgtcgactt ccaagcgctg gtccaatgtg
    19261 gaggcccagc tcggcccgaa tgcctgcccg atgcggtacg acgacaggtg ggtccggcgc
    19321 agcaccaacg gaagaacgcc gtcgagctcg acgtcagtct gcgtctgcag cattcgcccg
    19381 ctgttgacgt cgatcgggtc tccgcccgtg gtcagggatt tcgtctcgtc cgtgtggctg
    19441 gcgaggtcgc cgccgtgctt ggtgcctcgc gcgttcttgg cgaccttgga caggcccccg
    19501 accactttgc tgccgagttt ggctaccttg ccgaacggta tgaccgttaa ggcggtgtcg
    19561 acgagtatcg aggtgagact gccttcgccg gtggcggcgt agatcccggc gtcgatggcc
    19621 agcgcggcgc cgccggtgat gccggcggcg atgaggaagg cgccgccgac ggcgttgccg
    19681 accaccggga tcgcctgcaa caccacaccg atcaccgcga gcgcgcccga gacgaccttc
    19741 agcgccgagg agatctcctt gagcacgtcc ttgttctcgc ggatgaagtc ctgaccctgc
    19801 ccgatgaggt cgtagccggc cgggggctct ttgaaccgca tccccttggc gtcgttaatg
    19861 cgattcgtgc attcgcgggc cgcggcggtc atctccgtgc gcagaccatt cgccttgtcc
    19921 acgcagtcct gccacgccgc ccgcgccgac gacaacgccg ccgacgcatc ccccgcatcc
    19981 gactcatacg cagcacccgg cggcggcgcg tgtccggccg gagcatgggc ctgtgcgtca
    20041 cggaccttgt ccgcatgagc acggtccgca ctctccgccc gctcgacacg cccctcgctg
    20101 gccttgagct gctcccacaa gccgggcgcc tgatgcgcca gcggtcgcat cttgccctgc
    20161 agctccgaca accgcgacga gaaggtgttc agcgccgtgc cgacctggct gaaggccgtg
    20221 ccggtcaccc gcaggtccgg cggcagctcc gaatcgatct tgtcccggaa ctgctccgcc
    20281 tccggaccct ggaactcgcc ggtatccatg ccggtgatcc gctccgccgc gtgcgacgcg
    20341 gacccgccga aacggtcata ccggcgggcc gaacccgcga tcgcttccgg tgatccaccc
    20401 agcgagaaca agtgctccgg aaaatccgcc atcgcgaccc ccacatcacc agggctcatg
    20461 tccgcggtgg tgtgcgccaa cacctctgca cggccgacac cgcgacgagc agcactcaag
    20521 cgcgaccact acccatgatc acgacagacc gctgaaagtt tacgacaccg gctcgccccg
    20581 tagagaccga acgaagaatc ccgccctccg gaagctgaca ccgactgcgc cgacgagttc
    20641 gcgttggtgc agtccgggga ataccgccgc ggagctggcc agaggctcgt tagtcctact
    20701 tgtcgatgtg ttcgctcagt tcgaccgctc ggggatcgtg caagtggtcg gccagcgcgg
    20761 cggcctgctg ccatgagtcg cccgcgagat cgtgctcgcc gcgagcgtga gcgaggtgcg
    20821 cagcagcgtc caagatcccg atcagtgacc actcgtcgct ggcgttctcg gcgatctggt
    20881 ggccagcggt aagtgcggct tcggcctcct cataacggcg ctgttgggta cgcaaccgcc
    20941 cacgggtttc gtggaaggcg gcaagcaacg tcggatcgac ctcgtggtcc ggcagggcgt
    21001 tctcggcgtg ctcgagcgcc tggtcgcagc cctccagatc acctgcggca agccgaccac
    21061 cggcacggaa cacccatgcc agtgtcggcc cgttgggcac ctcggcacgc tggtgtgccg
    21121 cgatggcctc ggacagaacc gcgtcggcgt gggcggcatc agcaccggag acgaccagcc
    21181 agcgggccag ggtcagcaag ctccagccca ggccagcatc gtcggcgacc tgccggcgat
    21241 gctcgaccgc gacctcggcg aaggtgatgg cctgctcgac cgctccgagt tcaccgcaga
    21301 tggtggcgcg gacgtgggcg gcccagcctt gcccgtggtg atcggtctcc ggcagttccc
    21361 gcgcgacttc cgcggcgagt tggtcccaca gcgaccactg tttgcgcagc agcgcgtagt
    21421 ccaacaccgc gccgagaagg cgccaagccc aggtgtgttc gccgcggcgc agtgcggtgc
    21481 gcacgtggat cgaccacacg gtccataggt gatcgcacca agccagcagg gccgtgcggt
    21541 ccgtggtggg cagagagacc tcgaactcgg gagccgggat ctgcggagcg atctgccggc
    21601 ctggggccag cacgtcgccg gccgcggcga agctggccgc cagccacgcc agggcgcgtc
    21661 ccacgcccgc ggtcagcccg tcgggctcgt cctcggcagg ctcggtacgc gcccacgcca
    21721 ggtgcaggtc gaggaagtgg taaccggcgc cggagggatt cagcagcgaa gcgtctacgg
    21781 ccgcgtccag cagccgccgt gcctcggctt ggcgcagtcc cagcaaggcg gccgcggtcg
    21841 gcagcggcac agttggaccg agctgcgcag cccagcgcca ggcgcgttgc acgtcgggcg
    21901 gcagggacgt gtaggaagcg tggatcgttg cccagagcgg atcagcaggg tggagcagat
    21961 cgtcagccat gctggtgatt gtcgcgcgca acgccggttc gttgaggccg ttatggcgag
    22021 ctagggctgc accaacaccc gcaagaacca acggcacccc accggatgcg cccgcgagtg
    22081 gggcgacgtg gtcaggggat agaccgctgc gacgcaccag cacccgcacg cacgcctcgg
    22141 actcgagcgg gccgagatgc actcgcagca ccgaatcgtc atcggctcga tgcccaccca
    22201 caccgcgatc tctgctggtc acgatggtga tcccctctgg gtgcggcaag ccgatctcag
    22261 cggcttcctc gcgatgcccg gcgtccaggt tgtcggcgac caccagcagc tgccgttgga
    22321 gcgtcgcctc gcggtaaacc gcgcgcacct gtcccggatc accgccgggg tccgcaccca
    22381 acgcgcggca ccacgacgcc accaccgccg taatctccgc acccggcaca ttcggcgtcc
    22441 agccgcgaaa gtcaccgaac aactggccat gcggcaccag ctcgtcctcg atcaagcggt
    22501 gcccgagttc gatggccagc gcggttttcc cgatgccgcc cggcccggtg atgatcagcg
    22561 ccgggcgcgg tcgggatcgg caccacgcca acgcctcctc aaccacctcg cagcgcccgg
    22621 tgatccagga gcgccgtggg agctgcgagg gcaccaacga cgggccgtgc ccggccaacc
    22681 gccgatgcac atcaacgaga cccggatcgc ccaacacccg ggcgaagatc tcagcggtct
    22741 tcgcgctcgt gcggcgcgtg ccgcgcacgg cgtgcgagac ggtgccgatg ttgatgtcgg
    22801 ccttgcgcgc gagcgtgcgc gttgaccatc cccgctcggc catgcgctga gtcaggcgct
    22861 gccggaactc ctccacggcc cgagcgtgaa ccagttgtca tcggcgagca cacgtcgctg
    22921 ctagcccaaa taggtgaacc tcgggggatt gccgcaaccg caatccccgg caaagctgcc
    22981 gatcagcatc ggcagctcag cacggtgccg acatggacac agcaatcgat accccagcgg
    23041 gacaccggcc cgcgaaaacc ccgccgctcg gattcctgct cgcctgggag gcaggctcgg
    23101 acaccgccgc cgtttcgccg gtccaacgcg acggcgcact cggctacccg cgattcgtgg
    23161 tcctcgggaa ggcgaccctg caccgcttgt ccgaccacgc gaccagcacc cccgtaggcg
    23221 tactgcggct gcacctccgg tccgcaccga ccgcgctgga ggtggtgacg ccgtgagcac
    23281 gaccacccgc cgcgtccgga cgacgttcct cggcggcgcc gccttcgtcg cggcactgct
    23341 aatggccgct gcgggcccgc ccgccagcgg cgacacattc ggctgcgtgg ccaccctgga
    23401 cctcccagat gaggcggtcc gggcagacaa ccagtgccct agcacggaaa tctgggtcgg
    23461 catcgaccgg ttcggcgtcg acgggccctg cgtgccgatc cgcggagtgt tcaccggcga
    23521 ctcgcgctac ggcactcacg tgatctggaa tcggcagcag gcgaacggcg gccacgcgcg
    23581 cgacgtgtac gagtgccctc cgccgggtgc ggagcgcgcg atagcgcgcc acccctgacg
    23641 cctgagtgct gacgattcgt ctgacaccgc ggcatcggct tggctttccc ggagtgaccc
    23701 tgccgaggcg cccatcacgg gtgggttcac atgccgcacc caccgcacag gcgttgaccg
    23761 cctccgaagt tgatcagaag gcaacaccta tgcctaggag tactcatgag ccaagacgtg
    23821 gcatggccga cgttcccact ggggctgttg ggattcgaga actacgaact tcgtcgccag
    23881 atcgagttct ggcgggatta caccgccgag ttggagcggg agttggcgcg ggtgagttcc
    23941 caggcatggg acaccgtggc cgaggttcct ctccgggccg tatgggaatc cattgtggat
    24001 gcccgtctgg ccgaagaacc cgaccgtact gcggtggttt gggccgatct cgaccagttc
    24061 aagcagctga acgaccggta cggacacctg gccggggacg cagttctgcg tgaagtggcg
    24121 cggcgcttgg aagaagcctt cgccgcccat gctccggtgg tgacccgtct cggaggagat
    24181 gagttcggcg ttgtggtccg cgatctcgat ccggaagccg atctcgcgcg gttcgccgcg
    24241 ttgatggacg agccggtctt gctgccgcat ggccgctcgg tgcgcgttgc tgcctcggtg
    24301 ggcttcgccc gcgccagcga acttgtaccc ggcgccagca gagacgagct gttgcggcgt
    24361 gcggacgcgg gtgcgtatgc ccacaaatcc caccacctac cgggcgcacc gagtccgcgt
    24421 tcccgcaagc gcgtcgcggc gactgacgtg ttgggagcgg tgcaatgaac cgcagagaga
    24481 gaacgggctt cgggcatggg cacgatgctg tgcggcctgg tcgccgctcc gttggtgacg
    24541 atcgggctga tgccgtggct gccgcgatgg acctggtgga tgcccgggct ggtgggcggt
    24601 gggttggcgg tgctgtccgc ggcggtgcag gcgcggttcg gttcggaccc agtgtgggcg
    24661 gcgtggtggt ggctagctgt atgaggccat gacgttggtg acgccggtgg agagccggga
    24721 tgctggtggc tgatctccgg cggcagtgtg tggccgatgg tagttgtagt gcacgttcca
    24781 gaccgccaga gccgcggt
//
