LOCUS       NZ_JADDUE010000012     21197 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Saccharopolyspora sp. HNM0986
            NODE_12_length_167405_cov_77.073713_cov_77.073713, whole genome
            shotgun sequence.
ACCESSION   NZ_JADDUE010000012
VERSION     NZ_JADDUE010000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Saccharopolyspora sp. HNM0986
  ORGANISM  Saccharopolyspora sp. HNM0986
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (bases 1 to 167405)
  AUTHORS   Li,F.
  TITLE     Diversity and distribution of actinomycetes associated with coral in
            the coast of Hainan
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 167405)
  AUTHORS   Li,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2020) chool of Life and Pharmaceutical Sciences,
            Hainan University, 58 Renmin Avenue, Meilan District, Haikou, Hainan
            570208, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 232.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016526145.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 02:15:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,899
            CDSs (total)                      :: 5,838
            Genes (coding)                    :: 5,784
            CDSs (with protein)               :: 5,784
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 7 of 54
            Pseudo Genes (incomplete)         :: 49 of 54
            Pseudo Genes (internal stop)      :: 0 of 54
            Pseudo Genes (multiple problems)  :: 2 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:09:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 111741
            Orig. end                         :: 132938
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADDUE010000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21197
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="amglyccycl"
                     /region_number="1"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /tool="antismash"
     cand_cluster    1..21197
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21197
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11197](-)"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11197)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     gene            complement(792..2156)
                     /locus_tag="INP57_RS24645"
                     /old_locus_tag="INP57_24655"
     CDS             complement(792..2156)
                     /NRPS_PKS="Domain: AMP-binding (44-341). E-value: 9.5e-33.
                     Score: 105.3. Matches aSDomain:
                     nrpspksdomains_INP57_RS24645_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945480.1"
                     /locus_tag="INP57_RS24645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24655"
                     /product="fatty acid--CoA ligase family protein"
                     /protein_id="WP_200072712.1"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-26, bitscore:
                     86.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLPILGRRLTAGVSCGADVLDGAEIMRHAQGAAGELAGVDRVAV
                     DDPDPLHRLCWLLGADLAGAATLIVDPDWPRPQDVLDEAKPGRVVRGLPIPGEPPETPR
                     GDELTWFYLPTTSGSSGTPKVLARSRKSWLRSFTALDAPLRDDDSALIPGPLSSSLYLF
                     GALHALHQDRDVRLLRRWSARTAAQECLHATVVHVVPAMLAELLSVWERHPELRASCAL
                     RLIVCGGADLAPELETRLHALLPGCELLEYYGSAETSLIALRRGEHRLRPVVDVEILDA
                     QGNPVSEGELRVRSELAFDGYLRQGVLEAPESDRISVGDRAVRHDDGGLSVLGRCSATI
                     STGGTLVAAEEVESALRGRGVREVLVTGTPHPRLGALVTAVVEVDPAAPATREELRARV
                     RELEPVKRPRRWLTVPELPRTGSGKPARGVLDEWLRNGAPQAEVLRPSTPSQERP"
     aSDomain        complement(1134..2024)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_INP57_RS24645_AMP-binding.1"
                     /evalue="9.50E-33"
                     /label="INP57_RS24645_AMP-binding.1"
                     /locus_tag="INP57_RS24645"
                     /protein_end="341"
                     /protein_start="44"
                     /score="105.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VDDPDPLHRLCWLLGADLAGAATLIVDPDWPRPQDVLDEAKPGRV
                     VRGLPIPGEPPETPRGDELTWFYLPTTSGSSGTPKVLARSRKSWLRSFTALDAPLRDDD
                     SALIPGPLSSSLYLFGALHALHQDRDVRLLRRWSARTAAQECLHATVVHVVPAMLAELL
                     SVWERHPELRASCALRLIVCGGADLAPELETRLHALLPGCELLEYYGSAETSLIALRRG
                     EHRLRPVVDVEILDAQGNPVSEGELRVRSELAFDGYLRQGVLEAPESDRISVGDRAVRH
                     DDGGLSVLGRCSATIS"
     misc_feature    complement(1410..1412)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2153..2743)
                     /locus_tag="INP57_RS24650"
                     /old_locus_tag="INP57_24660"
     CDS             complement(2153..2743)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010234530.1"
                     /locus_tag="INP57_RS24650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24660"
                     /product="biotin transporter BioY"
                     /protein_id="WP_200072713.1"
                     /transl_table=11
                     /translation="MPGQRTAPATELARTVVFAAFIAVLGLFPGFYLGGAAVPVVLQNM
                     GPLLAGSILGARRGGASVLLFLGLVVIGLPLLSGGRGGIAPFAGPSGGFLLGWLLSAFV
                     VGLIVQRATPRPGLAVLLLANLAGVAVDYLVGIPYWAAFTGDLGAAAVQSLVFVPGDAV
                     KLVLVSLVAVAVHRALPASLSGSAQGGSRTARE"
     gene            2919..3290
                     /locus_tag="INP57_RS24655"
                     /old_locus_tag="INP57_24665"
     CDS             2919..3290
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS24655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_24665"
                     /product="GRAM domain-containing protein"
                     /protein_id="WP_200072714.1"
                     /transl_table=11
                     /translation="MTTQLPGNVAPTDDGEIVTWRRWANRTQSNSRAAGGRLYLTNRRV
                     LFCPHAFDANTGGEYRSIPLAAITEVGKQPRTLNLRAAYNGGLRTRLRIDCADGSTELF
                     VLNKLDQVITEIRAATGPA"
     gene            complement(3442..4125)
                     /locus_tag="INP57_RS24660"
                     /old_locus_tag="INP57_24670"
     CDS             complement(3442..4125)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024098.5"
                     /locus_tag="INP57_RS24660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24670"
                     /product="DUF3800 domain-containing protein"
                     /protein_id="WP_200072715.1"
                     /transl_table=11
                     /translation="MIVRVFYVDDSGSEQHGINVFGWVELELGAWNQVLRGWLDWRQEL
                     YRSIGLATDYELHATKFLGGRGRPTGTDWDTAKPNRSQVMRDALSTIDGLDGLAAGAVF
                     LRTTPGVKHPAAKADAYARLVRYLDARLTAAGELGLIMMDGDGSDHTYRGAHRELKLAT
                     RSVIEDPLFQHSHHSQWVQMADLVAYAAFMRVERMVGKPFAWEWFTLLADCSTSGVEPL
                     DRHLA"
     gene            complement(4251..6425)
                     /locus_tag="INP57_RS24665"
                     /old_locus_tag="INP57_24675"
     CDS             complement(4251..6425)
                     /EC_number="3.6.4.12"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016697034.1"
                     /locus_tag="INP57_RS24665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24675"
                     /product="ATP-dependent DNA helicase"
                     /protein_id="WP_374220966.1"
                     /transl_table=11
                     /translation="MPGSVPQWSDPDVFAPDDSDDLPPEIAADLAKQGGPQQAQHRSEP
                     STAKPPEQVPELAELLEIAVRSVGGTEREGQARMADAVEHSIGSGEHLAVQAGTGTGKS
                     LAYLVPAIRHAVTAATTVVISTATIALQRQLVDRDLPRLATALAEALGRPPTFAILKGR
                     RNYLCLNRIHGNAPEEPDEGALFDPFAASALERQVKRLREWATETESGDRDELVPGVTD
                     QAWRQVSVTAKECLGVQRCPVGTDCFAERARGEAGRADVVVTNHALLAIDALDDRPVLP
                     EHDVVMVDEAHDLVDRVTSAATGELTGGQAKLAARRCGRAIDQSIADRLDEAAEGLETV
                     LEDAPAERLEAMPEALGGALTALRDAGAACMTALGPERKEDVEGSTARRLALALTEELH
                     DTAVRLLDAFDEPEGQRRDVVWISAEPNRPRAVKVAPLGVGGLLRERLFGQRTTVLTSA
                     TLALGGSFDTLARQWGLPPERQAAAAEDMASRKEAPSDSSSTAWTGLDVGSPFEHRRSG
                     ILYIARHLPPPGKAGLPDEYLDELTELVQAAGGRTLGLFSSMRAAKQASEQLRDRLSTP
                     VLCQGEDNTAQLVAKFSESPETSLFGTLSLWQGVDVPGDSLQLVVMDRIPFPRPDDPLA
                     SARQKAVSAHGGNGFITVAGTHAALLLAQGAGRLLRSVHDRGVIAVLDPRLATARYGSF
                     LRASLPPFWATYDPQVVRGALGRLNAAASG"
     gene            complement(6573..7175)
                     /locus_tag="INP57_RS24670"
                     /old_locus_tag="INP57_24680"
     CDS             complement(6573..7175)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019808402.1"
                     /locus_tag="INP57_RS24670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24680"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_200072716.1"
                     /transl_table=11
                     /translation="MTERGRPRAFDREVALHKAMEVFWASGYEGTSIGDLTAAMGINAP
                     SLYATFGSKEGLFRSATERYNTVEGRAANDALHRAATARLAVESMLRSYARSYTDPATP
                     RGCMIVLAANVGTARNAGVREHLAGLRREVLATLRQRLERGIAEGDVRADTDTASVATF
                     YATVLQGLSIQAKDGASLADLEGVIDHAMSAWPAAPS"
     gene            7294..8034
                     /locus_tag="INP57_RS24675"
                     /old_locus_tag="INP57_24685"
     CDS             7294..8034
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (9-168). E-value: 1.6e-11. Score:
                     36.4. Matches aSDomain:
                     nrpspksdomains_INP57_RS24675_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009072413.1"
                     /locus_tag="INP57_RS24675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24685"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_200072717.1"
                     /transl_table=11
                     /translation="MAELAGKKALVVGGSRGIGAGAASGLASNGADVAITYSGSKDKAH
                     SVVRDIEASGVRGAALPLDGMDADSARVAVDEAADRLGGLDILVNCAGIFPYGLIEDVT
                     LEQFDQAIAVHVRTAFLTTQAAVRHMSGGGRIIHIGTSFVERVPFPGVSLYTLSKSGLT
                     GFAKALARELGPRGITVNVVHPGPTDTDMNPADSEGADGQRAITALGHYGVVEDIANTV
                     VHLSGAGGRHITGASIPVDGGWAA"
     CDS_motif       7321..7386
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_INP57_RS24675_0001"
                     /evalue="7.10E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="INP57_RS24675"
                     /protein_end="31"
                     /protein_start="9"
                     /score="9.1"
                     /tool="antismash"
                     /translation="LVVGGSRGIGAGAASGLASNGA"
     aSDomain        7321..7797
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_INP57_RS24675_PKS_KR.1"
                     /evalue="1.60E-11"
                     /label="INP57_RS24675_PKS_KR.1"
                     /locus_tag="INP57_RS24675"
                     /protein_end="168"
                     /protein_start="9"
                     /score="36.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LVVGGSRGIGAGAASGLASNGADVAITYSGSKDKAHSVVRDIEAS
                     GVRGAALPLDGMDADSARVAVDEAADRLGGLDILVNCAGIFPYGLIEDVTLEQFDQAIA
                     VHVRTAFLTTQAAVRHMSGGGRIIHIGTSFVERVPFPGVSLYTLSKSGLTGFAKA"
     gene            8370..9908
                     /locus_tag="INP57_RS24680"
                     /old_locus_tag="INP57_24690"
     CDS             8370..9908
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020640551.1"
                     /locus_tag="INP57_RS24680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24690"
                     /product="FAD-binding protein"
                     /protein_id="WP_200072718.1"
                     /transl_table=11
                     /translation="MATISKEARQYPDLTSGYNQRWSGTPESVVLVESVEQVAPVVQEA
                     VRDGKRMTVNGAGHCFEDFVYNSDVDVVINMKHLDAVYYDPAMNAVAVEAGSNLLNVYK
                     KLYERWGVTLPGGLCYSVGVGGHVSGGGWGALARRHGLIVDHLYAVEVVVVGEGGEVRR
                     VVATREEDDPNRDLWWAHTGGGGGNFGVITRYWFRSPGATGREPGEILPRPPRHVLLSA
                     AALSWDEITEAGFTRLVNNYADWHVRNSRPGSRAAGLFGLAVLNHRSNGQIGLITQVEA
                     DLPGADDLLAEYLDAITDGVGAPLQPMTASMGEYNAMPGCYEAQRLPWLQATRFLGTNN
                     VDLNNPTLRADYKSGYMRGNFPDKHVATMYQSLTSTDIDNSTATMHLQGFGAQVNAVPE
                     SATAFAHRSSFFKLYWQVLWDDPADDDEHLTWLRRFYADLYRDTGGVPVPNELTDGCYV
                     NYPDVDLNSAEHNQSQVPWYRLYYKENYERLQQVKKRFDPRDVFRHAQSVRLPD"
     gene            complement(10001..11197)
                     /locus_tag="INP57_RS24685"
                     /old_locus_tag="INP57_24695"
     CDS             complement(10001..11197)
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102640.1"
                     /locus_tag="INP57_RS24685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24695"
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_200072719.1"
                     /sec_met_domain="salQ (E-value: 9.9e-174, bitscore: 570.8,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 5e-67, bitscore:
                     219.1, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPTATESFAPWRDRSEASRNRWTVTATRPVSYDVALCDGILDPA
                     NPALLRAVPRGVPPTARRLLVIDSEVHRHYGRSFTDYFERHSIPSATCVLDCDETTKHW
                     GNVRTVLQALDRFGIDRRNEPIVAAGGGVLLDVVGFAGSLYRRGTPVVRVPTTLIGLVD
                     AGIGVKTGVNFDEHKNRIGTYHAADRVVLDPAFLRTVDRRHLSNGLAEILKMALIGDRR
                     LFDLLDWHGAGLLAAKFQRDGRHREAATEVLERSIGGMLDELQPNLWESSLERVVDYGH
                     SFSPTLEMRALPELLHGEAVSIDMALSTLLAEARGLVTATERSRVLRLMRALELPISHP
                     LCTSELLISALGDTTRHRGGRQRLPLPVGIGAARFVDDVDERELEVAGESLAELAKNG"
     gene            complement(11198..11845)
                     /locus_tag="INP57_RS24690"
                     /old_locus_tag="INP57_24700"
     CDS             complement(11198..11845)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013098.5"
                     /locus_tag="INP57_RS24690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24700"
                     /product="VOC family protein"
                     /protein_id="WP_200072720.1"
                     /transl_table=11
                     /translation="MGSGIPGARNVDHVAFTVPDLQRAVDFFVDVLGAETIYWEGPVQD
                     LAGDWMTRKLNVHERATARIAMLRLGPTTNLELFEYTAPNQQRRIPENSDHGGHHLAIY
                     VDDVDVAAEYLRNQPGVRLQGEPETIEEGPLAGNRWMYFTAPWGMQLEVVDMPAGMPYE
                     QRTAARKYGPAPRWDNRAEQNRDAIPSSADANAAGDPHPSRNTGANLTEKER"
     gene            complement(11838..12248)
                     /locus_tag="INP57_RS24695"
                     /old_locus_tag="INP57_24705"
     CDS             complement(11838..12248)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032085.1"
                     /locus_tag="INP57_RS24695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24705"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_200072721.1"
                     /transl_table=11
                     /translation="MIVTDSRGLVLTADERTGVIRSRCLARRGMLYSECEAVDYLLLAP
                     GAAQDARGQSGVELAVLVLGGSGELSDTRRDRPAPLRPGALVLAPAGSGTVLRNTGEAE
                     LELLLIAVFPESVTGRLPIRKPVERPAGAGDG"
     gene            complement(12245..12997)
                     /locus_tag="INP57_RS24700"
                     /old_locus_tag="INP57_24710"
     CDS             complement(12245..12997)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032086.1"
                     /locus_tag="INP57_RS24700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24710"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_233628218.1"
                     /transl_table=11
                     /translation="MVDAVIVADLNEPSDIHGMHSGEGLARWKVLARRGSLFGYWEAVE
                     WSALPPGGVSGEHIHSRTEELYFIVSGDGEMTLNGRTHQVRPGHLIVNGLGTRHGLRNT
                     GDEELVWLVIEVSGPHTAAVLDTPRETPRHEPERTAMSDAVVIDLRQAGQVDTTEHLTG
                     PLRLARLVRLRPGEPLELSADSEEHTVYTIGGQGRARGSSETVALRSGVGLTLPLGGTV
                     SIEAASQREPLELFVVSLAVPGAAGGRQ"
     misc_feature    complement(13405..13418)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.45"
                     /tool="antismash"
     misc_feature    complement(13406..13419)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.72"
                     /tool="antismash"
     misc_feature    13406..13420
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.7"
                     /tool="antismash"
     misc_feature    complement(13408..13424)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.66"
                     /tool="antismash"
     gene            13608..14279
                     /locus_tag="INP57_RS24705"
                     /old_locus_tag="INP57_24715"
     CDS             13608..14279
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101310.1"
                     /locus_tag="INP57_RS24705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24715"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_200072722.1"
                     /sec_met_domain="Methyltransf_3 (E-value: 1.3e-65,
                     bitscore: 213.9, seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 3.9e-06, bitscore: 20.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVQVEVTSALQDYIAEMSLREPAALAALREETEQMPGAIMQVSP
                     EEGQFLGVLVRALGASRVLEVGTFTGYSTISIARALPAGGSVLSCDISSEASSIALAHA
                     RRAGVEDKVDLRVGDAVGVLTGLTGLAGRADRRGSFDLVFIDADKEGYADYYEIALRLV
                     RPGGLILVDNVLWHGAVLDEAEQDSETTAIRAFNEKIREDERVDLSILPFADGLAFAVK
                     R"
     gene            14321..14941
                     /locus_tag="INP57_RS24710"
                     /old_locus_tag="INP57_24720"
     CDS             14321..14941
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019498.5"
                     /locus_tag="INP57_RS24710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24720"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_200072723.1"
                     /transl_table=11
                     /translation="MVVRSKEVYDNPVCGERVVIRRGNDEGDGSVLIWDLYLEPGGTVV
                     GEHYHPTADERFVLVSGKLGIRAGGRSRVLEEVGESVLAEAGTRHYFWNGDSGPTRIVI
                     RMQGRVDRFEQAVFRQLYGLAQDGRTDSNGKPGLLQHAVTSAEYADIVRFAAPPWPVQR
                     LLFGVLAPVGRALGYRALCAEYRDRRAPLVAELDPLPPGFPEL"
     gene            complement(14967..15536)
                     /locus_tag="INP57_RS24715"
                     /old_locus_tag="INP57_24725"
     CDS             complement(14967..15536)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007026070.1"
                     /locus_tag="INP57_RS24715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24725"
                     /product="isochorismatase family protein"
                     /protein_id="WP_200072724.1"
                     /transl_table=11
                     /translation="MSTALLIVDVQLDFCEGGALGVSGGAGVAAAISRHAAENEYAHVV
                     ATRDYHVDPGDHFSSQPDYVRSWPVHCVAGTAGAAFHPELEVGPVRAVFSKGQYSAGYS
                     GFEGKDRLGTPLRDWLGERGVDAVDVVGIATDHCVRATALDAAKAGLTTTVLLSLTAGV
                     APATVDTAVRDLRAAGVALTGTPVVA"
     gene            complement(15566..16867)
                     /locus_tag="INP57_RS24720"
                     /old_locus_tag="INP57_24730"
     CDS             complement(15566..16867)
                     /EC_number="6.3.4.21"
                     /GO_function="GO:0004514 - nicotinate-nucleotide
                     diphosphorylase (carboxylating) activity [Evidence IEA]"
                     /GO_function="GO:0004516 - nicotinate
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945473.1"
                     /locus_tag="INP57_RS24720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24730"
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="WP_200072725.1"
                     /transl_table=11
                     /translation="MTAASSTALRTDHYELTMLASALRDGTAERRCVFEVFTRRLPDGR
                     RYGVLGGMQRVLDAIENFRFDEAELTRLAEAGVVDETTLDWLRNYRFQGDVDGYPEGEL
                     YFPGSPLLTVRGTFAEAVLLETVVLSILNHDSAIAAAAARMVSAANGRRIIEMGSRRTH
                     EESAVAAARAAYLAGFSGTSNLEAGRRYRIPTMGTSAHSFTLLHDSERAAFESQIAALG
                     ADTTLLVDTYDISRGIATAVEVAGSGLGAVRIDSGDVGVLARQAREQLDSLGATGTRVV
                     VSGDLDEYAIASLRAEPVDGYGVGTSLVTGSGAPTAGMVYKLTEVEGRPVAKRSSSKES
                     RGGSKSALRRHKNTGTAIEEEVYRTGSGFAAPQPGPHDREVPIPLVRGGKQVDDLPTLE
                     DNRERLRHALVSLPWEGLKLSGGEPAIPTVFPES"
     gene            16970..17257
                     /gene="clpS"
                     /locus_tag="INP57_RS24725"
                     /old_locus_tag="INP57_24735"
     CDS             16970..17257
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="clpS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657344.1"
                     /locus_tag="INP57_RS24725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24735"
                     /product="ATP-dependent Clp protease adapter ClpS"
                     /protein_id="WP_200072726.1"
                     /transl_table=11
                     /translation="MTSPAELERAQPNELGNEDKPWVTVVWNDPVNLMSYVTYVLQKIF
                     GYSRDHATKLMLDVHHKGRAAVSSGTKEKVEGDVAKLHANGLWATMQKDS"
     gene            17264..17827
                     /locus_tag="INP57_RS24730"
                     /old_locus_tag="INP57_24740"
     CDS             17264..17827
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005165656.1"
                     /locus_tag="INP57_RS24730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24740"
                     /product="DUF2017 domain-containing protein"
                     /protein_id="WP_200072727.1"
                     /transl_table=11
                     /translation="MNGWTRKNGHVVAELSQQEAAVIRGLVGQIKDMLDARADEAPQDE
                     LAELTGIRTGPSTPPEDRVLERLLPDFYRRDPETGETDEEKPAAAGAMRSLYEPELLDR
                     KTGTAAVVLETCPRDGGRVVLSGEQADNWLSAINDVRLALGTALDVQEDMPEEPPEDDL
                     RREHLGVYQWLTWVQDSLVETLTS"
     gene            18059..19114
                     /locus_tag="INP57_RS24735"
                     /old_locus_tag="INP57_24745"
     CDS             18059..19114
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945470.1"
                     /locus_tag="INP57_RS24735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24745"
                     /product="P1 family peptidase"
                     /protein_id="WP_200072728.1"
                     /transl_table=11
                     /translation="MRSGARNSITDVRGVLVGHEQRLDEQWATGTSVVLTAGGASAAVD
                     VRGGGPGTRETDVLEPTHAVQQAHAIVLTGGSAYGLAAADGAMRWLGEREHGFPVGTEP
                     HEIVPVVPAAVLFDLPMGDWGNRPDAAFGHRACDAASATEAREGNVGAGTGAVAGSLKG
                     GTGSASAVFTSDVLGSEVTVGALMAVNSSGSVIDPETGLPWNPHPGLRAPSADEIAAGK
                     RLGPRPSRHGTAQRPVNTTIGVVATDLALTKPQCHRIAVAGHDGLARAIRPAHGMSDGD
                     TVFALSTGSPAASRERDSDQRLAGAEARLLDEVCAAAADVVQHAIVRAVLAAEPVGEVT
                     SYTRTYPSARE"
     gene            19215..19670
                     /locus_tag="INP57_RS24740"
                     /old_locus_tag="INP57_24750"
     CDS             19215..19670
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012783627.1"
                     /locus_tag="INP57_RS24740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24750"
                     /product="M67 family metallopeptidase"
                     /protein_id="WP_295143081.1"
                     /transl_table=11
                     /translation="MLVIRRDLVDAMVAHARRDHPDEACGVIAGPDGSDRPERFVEMIN
                     AERSPTFYRFDSSEQLKVWREMDQADEEPVVIYHSHTATEAYPSRTDVSYALEPNAHYV
                     LVSTRDPETHELRSYRILDGVVTEEPVEIVESYMFAHTGTDEVPDRG"
     gene            19751..20029
                     /locus_tag="INP57_RS24745"
                     /old_locus_tag="INP57_24755"
     CDS             19751..20029
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019812882.1"
                     /locus_tag="INP57_RS24745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24755"
                     /product="MoaD/ThiS family protein"
                     /protein_id="WP_200072730.1"
                     /transl_table=11
                     /translation="MAINVSIPTILRTHTDGQKSVEASGNTVAEVINDLDSKHSGLKDR
                     LVKEGSLHRFVNVYVNDEDVRFSGGLEASVADGDSVTILPAVAGGMR"
     gene            20046..20996
                     /locus_tag="INP57_RS24750"
                     /old_locus_tag="INP57_24760"
     CDS             20046..20996
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657349.1"
                     /locus_tag="INP57_RS24750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_24760"
                     /product="PLP-dependent cysteine synthase family protein"
                     /protein_id="WP_200072731.1"
                     /sec_met_domain="PALP (E-value: 4.1e-63, bitscore: 206.9,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARYDSLLDALGDTPLVGLPHLSPAPDVRLWAKLEDRNPTGSVKD
                     RVALSMIEAAEKEGRLTTGCTILEPTSGNTGISLAMAAKLKGYGLVCVMPENTSEERRQ
                     ILQAFGARIVSSPAAGGSNQAVAVAKELAQQNPDWVMLYQYGNSANADAHYRGTGPEIL
                     RDMPGLTHFVAGLGTTGTLVGVGRYLHEHKPGVQIVAAEPRYGELVYGLRNLDEGFVPE
                     LYDESVLSRRFSVGSYDALRRTRQLLESEGIFAGISTGGVVHAALTIGEKAAAAGESAD
                     IVFVVADAGWKYLSTGAYGGTLDEAAQRLDGQLWA"
ORIGIN
        1 cgcggtccgt tcggcggcca gccgcaggcc gggcacgccg agtgcgcggc gctcgtcctc
       61 ggtggtgagc agcactgcgg ccgccccgtc gctgacgccg cacgagttcg cggcggtggc
      121 cgtgccgtcc ggggtgaacg cggggcggaa ccggctcagc cgctgcgcgg tgaagttgcg
      181 ccgcgggcgt tcgtcgcgcg cggcgccgac ctcgacgagt tcggcgtcga accggccgga
      241 atcctgcgcc gcgatcgcgc gggcgtggct gcgcgcggcg aaatcgtcct ggcgccggcg
      301 ggaaacgccc gcctcggcgg cgaccaggtc ggcggccggg cccatgtccg ggtcgccgat
      361 gtcggccggg gcgaacgggg cgcgcgagta gaaccgcggt ggctcaccgg cggtgcgcgg
      421 tcgccacgcc cgccacggcg cggtcgacgg gctctccacg ccaccggcca ggaaccgatc
      481 gccgaccccg gcgcgcagca gcgccgcagc ggtgaggatc gcgctgagcc cgctggcgca
      541 ctgccgatcc accgtcatgc cgggcacgtc gaacccgaac ccggcgcgca gcgcggcgac
      601 ccgcgccgga ttcccgcccg gcccgagcgc gttgccgagc agcacgtcgt ccacggtgtc
      661 cagcccggaa tcggtgagcg cggcgcgcag caccggagcg gcgagctgat cggtcgccac
      721 attgcgcagc acgccaccga cttctccgat cgggctgcgg cgcgcggcga tgatcacggg
      781 tgtccggtcg gtcacggtcg ttcctgcgaa ggggtgctcg ggcgcaagac ctcggcttgc
      841 ggcgcgccgt tgcgcagcca ctcgtccagc acgccgcgcg cgggtttccc ggagccggtg
      901 cgcggcagct cgggcacggt cagccagcgc cgcgggcgct tgacgggctc cagctcgcga
      961 acccgggcgc gcagctcctc ccgcgtcgcg ggcgcggccg gatcgacctc gacgaccgcc
     1021 gtgacgagcg cgccgaggcg ggggtgcggc gtcccggtca ccagcacctc gcggacgccc
     1081 cggccgcgca gcgcggactc gacctcttcg gcggccacca gcgtcccgcc ggtgctgatc
     1141 gtggcgctgc agcgaccgag cacgctcagc ccgccgtcgt cgtgccggac ggcgcggtcg
     1201 ccgacgctga tccggtccga ttccggggct tccagcacgc cttgccgcag gtagccgtcg
     1261 aaggccagct ccgagcgcac ccgcaattcg ccttcgctga ccggatttcc ttgcgcatca
     1321 aggatttcca cgtccaccac cggccgcagc cgatgctcgc cgcggcgcag cgcgatcagc
     1381 gaggtctccg cggagccgta gtactccagt aattcgcagc ccggcagcag cgcgtgcagc
     1441 cgcgtctcca gctcgggcgc caggtcggcc ccgccgcaga cgatcagccg cagcgcacag
     1501 gaggcacgca gctcgggatg ccgctcccac accgaaagca actcggcgag catcgcgggg
     1561 acgacgtgca cgaccgtcgc gtgcaggcac tcctgcgcgg cggtgcgcgc ggaccagcgc
     1621 cgcagcaggc ggacatcgcg gtcctggtgc agcgcgtgca gcgcgccgaa caggtacagc
     1681 gaggaactca acggccccgg gatcagcgcg gaatcgtcgt cgcgcaacgg tgcgtcgagc
     1741 gcggtgaagc tgcgcagcca ggacttccgg gatcgcgcca gcactttcgg cgtgccgctg
     1801 ctgccggaag tggtgggcag gtagaaccag gtcagctcgt cgccgcgcgg cgtttccggc
     1861 ggctcgcccg gaatcggcag gccgcggacc acccggcccg gtttcgcctc gtccagcacg
     1921 tcctgcggcc gcggccaatc cgggtcgacg atcagcgtgg cggctccggc gaggtccgcg
     1981 cccagcagcc agcacagccg gtgcagcggg tcggggtcgt cgaccgccac ccgatcgact
     2041 ccggcgagtt cgcccgccgc gccctgcgcg tgccgcatga tctcggcgcc gtcgagaacg
     2101 tccgcaccgc acgacacgcc ggcggtgagt cggcgcccga ggatcggcag ggtcattccc
     2161 gcgccgtccg ggaaccgccc tgcgcagaac cactcagcga agcgggcaac gcccggtgca
     2221 ccgccaccgc gaccagcgaa accagcacca gcttcaccgc gtcacccggc acgaacacca
     2281 gcgattgcac cgcggccgca ccgagatcac cggtgaacgc ggcccagtac ggaatgccga
     2341 ccaggtagtc caccgccacc ccggccaggt tcgccagcag cagcaccgcg agccccggac
     2401 gcggcgtcgc ccgctgcacg atcagcccca ccacgaacgc cgacagcagc cagcccagca
     2461 ggaacccgcc gctcggcccg gcgaacggcg cgatgccgcc gcggccaccc gacagcagcg
     2521 gcaacccgat caccacgagt cccaggaaca gcagcaccga tgcgcctccg cggcgggcac
     2581 cgaggatgct gcccgccagc agcggcccca tgttctgcag caccaccggc accgcggcgc
     2641 cgccgaggta gaacccgggg aacaggccga gcacggcgat gaacgccgcg aacaccacgg
     2701 tccgggccag ctcggtggcc ggggcagtgc gttgtccagg cacgacgact cctcaccgat
     2761 cgcggtccgg cgtcaaccta cccggctcgg cctgcggaac agaaagtgtt ccgtcccatt
     2821 gtggacactc cacaaccggg cggtgccggg cttgcccgca ttccccggct gccgcgaaga
     2881 tcgcgcccgg ccctacccga gtcccgaaag gggaagtcgt gaccacgcaa ctacccggca
     2941 acgtcgctcc caccgatgac ggcgagatcg tcacctggcg ccgctgggcg aaccggacgc
     3001 agagcaattc ccgcgccgcc ggcggcaggc tgtacctgac gaaccggcga gtgctgttct
     3061 gcccgcacgc cttcgacgcc aacaccggtg gcgaataccg gagcatcccg ctggcggcga
     3121 tcaccgaggt cggcaagcag ccgcgcaccc tgaacctgcg cgccgcgtac aacggcggcc
     3181 tgcgcacccg actgcggatc gactgcgcgg acggctccac cgaactgttc gtcctcaaca
     3241 aactcgacca ggtcatcacc gagatccgcg ccgcgaccgg cccggcctga atccctggta
     3301 ccgcgtcgtt gccgcgcccg gcgacggttg ctgccgccgg gcagtcctgg tgccgaccgc
     3361 aggcatcgtg tacattggtc gtcgcggacc cgtcccatgt gcttggggta gcgggtcttg
     3421 cttattgtcc ggggcgagtt ttcaggccag gtgccggtcg agtggctcta cgccgctcgt
     3481 cgagcagtcc gcgagcagcg tgaaccactc ccacgcgaac ggcttgccga ccatgcgctc
     3541 gacccgcatg aacgccgcgt acgccaccag atcagccatc tgcacccact ggctgtggtg
     3601 cgagtgctga aacagcggat cctcgatcac cgagcgcgtc gccagcttca actcccggtg
     3661 cgcaccgcga tacgtgtgat cactgccgtc cccgtccatc atgatcaggc ccagctcgcc
     3721 cgccgcggtc agacgtgcgt ccaggtaccg caccagccgc gcgtacgcat ccgccttcgc
     3781 cgccggatgc ttcactccgg gcgtcgtccg cagaaagacc gcgcctgccg ccaatccgtc
     3841 caaaccgtca atggtcgaca gcgcatcacg catcacctgc gaccgattcg gcttcgccgt
     3901 gtcccagtcc gtgcccgtcg gtcgcccgcg cccgcccagg aacttcgtcg cgtgcagctc
     3961 gtagtcggtg gccagcccga tcgagcggta cagctcctgc cgccagtcca gccagccgcg
     4021 cagcacctga ttccacgccc ccagttcaag ctccacccag ccgaagacgt tgattccgtg
     4081 ctgctccgag ccggagtcgt cgacgtagaa cacccgcacg atcatgacca caccgtacgg
     4141 aacgtgatcg gaagaaaacc caccgtgttc gttcgcggct ccgctcacca tcggcgagca
     4201 ggggagcggg ccccgcaacc gccgcttgat cggcgaccgc tcctgcgccg tcagccggag
     4261 gccgccgcgt tcagcctgcc cagtgcgccg cggaccacct gcgggtcgta ggtggcccag
     4321 aacggcggca gcgaggcgcg caggaagctg ccgtagcggg cggtcgccag ccgcgggtcg
     4381 aggaccgcga tgacgccgcg gtcgtgcacg gaccgcagca gccgcccggc gccttgggcc
     4441 agcagcagcg ccgcgtgcgt cccggcgacg gtgatgaacc cgttgccgcc gtgcgcggac
     4501 accgccttct gccgcgccga ggcgagcggg tcgtccggcc gcgggaacgg gatgcggtcc
     4561 atcaccacga gttgcagcga gtcaccgggc acgtccacgc cctgccacag cgacaacgtg
     4621 ccgaacagcg aggtttccgg tgattcggag aacttcgcga ccagctgcgc ggtgttgtcc
     4681 tcgccctggc acagcaccgg cgtcgacagc cggtcccgca gctgttcgga cgcctgcttg
     4741 gccgcgcgca tcgaggagaa cagcccgagc gtgcggccac ccgcggcctg caccagctcg
     4801 gtgagctcgt ccaggtactc gtccggaagt ccggctttgc ccggcggcgg caggtgccgc
     4861 gcgatgtaga ggatgccgct gcgccggtgc tcgaacggtg agccgacgtc cagcccggtc
     4921 caggcggtgc tggagctgtc ggagggtgct tccttgcggc tggccatgtc ctcggccgcg
     4981 gccgcctggc gctccggcgg caggccccac tgccgggcca gcgtgtcgaa ggacccgccg
     5041 agcgccagcg tcgccgaggt cagcaccgtc gtgcgctgcc cgaacagccg ctcccgcagc
     5101 agcccgccga cgccgagcgg ggccaccttc accgctcgcg gccggttcgg ctcggcgctg
     5161 atccaaacca cgtcgcggcg ctggccctcc ggttcgtcga aggcgtccag caaccgaacc
     5221 gcggtgtcgt gcagctcctc ggtcaacgcc agcgcgagcc tgcgggccgt gctgccttcg
     5281 acgtcctcct tgcgctccgg cccgagcgcg gtcatgcacg ccgcgcccgc gtcgcgcaac
     5341 gccgtgagcg ccccgccgag cgcttccggc atcgcctcca gccgctccgc aggcgcgtcc
     5401 tccagcacgg tttcgagtcc ttcggccgcc tcgtcgagcc ggtcggcgat gctctggtcg
     5461 atcgcgcgcc cgcagcgccg cgcggcgagt ttcgcctggc ctccggtgag ttctccggtg
     5521 gcggccgagg tcacccggtc gaccaggtcg tgcgcctcgt cgaccatgac cacgtcgtgc
     5581 tcgggcagca ccggccggtc gtcgagcgcg tcgatcgcca gcagcgcgtg gttggtcacg
     5641 accacgtcgg cccggcccgc ttcaccgcgc gcgcgttcgg cgaagcagtc ggtgccgacg
     5701 gggcagcgct gcaccccgag gcattccttg gcggtcaccg aaacctgccg ccacgcctga
     5761 tcggtcacgc ccggcacgag ttcgtcccgg tcgccggatt cggtctcggt cgcccactcc
     5821 cgcagccgct tgacctgccg ctccagcgcg gaggcggcga acgggtcgaa cagcgcgcct
     5881 tcgtcgggtt cttccggggc gttgccgtgg atccggttca ggcacaggta gttgcggcgg
     5941 cctttgagga tcgcgaacgt cggcggccgc cccagcgcct cggccagcgc ggtcgccagc
     6001 cgcggcaggt cgcggtccac cagctggcgc tgcagcgcga tcgtcgcggt ggagatcacc
     6061 accgtggtgg ccgcggtgac ggcgtgccgg atcgcgggaa ccaggtaggc gagggatttg
     6121 ccggtgccgg ttccggcctg cacggccaag tgctcaccgg atccgatgga gtgctccacg
     6181 gcgtcggcca tccgcgcctg gccctcgcgc tcggtgccgc cgaccgagcg gaccgcgatc
     6241 tccagcagct cggccagctc tggtacctgc tccggtggtt tcgcggtgct cggctcgctc
     6301 cggtgctgag cctgctgcgg cccgccctgc ttcgcgaggt cggcggcgat ctccggcgga
     6361 agatcgtcgg aatcgtcggg cgcgaacacg tccggatcgg accactgcgg aacggaacca
     6421 ggcaccctcc gacgctaccg cgcggccacg tcaaggctgc ggggcacaca ccggcgcgag
     6481 tcgggcggtg acgcatggat gggcgtggcc gcagccaagc ggctgctacg ccgcctgccc
     6541 ggcactcgca gcaccgcgcc gttcccagcg ggtcaggaag gcgccgccgg ccaggcgctc
     6601 atggcgtgat cgatcacgcc ttccaggtcc gccagggacg cgccgtcctt cgcctggatg
     6661 gacagccctt gcagcaccgt cgcgtagaag gtcgcgaccg atgcggtgtc ggtgtccgcc
     6721 cgaacgtcgc cttcggcgat gccgcgttcc aggcgttgcc gcagcgtcgc gagcacttcg
     6781 cggcgcagcc cggcgaggtg ctcgcgaaca ccggcgttgc gggcggtgcc gacgttcgca
     6841 gccagcacga tcatgcagcc ccgcggagtc gccgggtcgg tgtaggaccg cgcgtagctg
     6901 cgcagcatgg actccaccgc cagccgcgcg gtcgcagccc ggtgcagggc gtcgttcgcg
     6961 gcgcggccct cgacggtgtt gtaccgctcg gtcgcggacc ggaacagtcc ctccttgctg
     7021 ccgaacgtcg cgtacaggct cggtgcgttg atccccatcg cggcggtgag gtcgccgatg
     7081 gaagtcccct cgtacccgct ggcccagaag acctccatcg ccttgtgcag cgcgacctcc
     7141 cggtcgaagg cccgcggtcg tccgcgttcg gtcatctcgt gccctccccg gccggtgtcg
     7201 cggcttcctg ccgcaaattc tgcttgacgg ccaccagtgg tgacgtcaga ctacttctgt
     7261 atcgaccgat acagaacaat cgatggggga acgatggcgg agctcgcggg caagaaggca
     7321 ctcgtggtcg gcgggagcag gggcatcggg gccggagcgg cgagcggtct cgcgtcgaac
     7381 ggcgcggacg tggcgatcac gtactcgggt tcgaaggaca aagcgcattc cgtcgtgcgc
     7441 gacatcgagg cttcgggggt gcgcggggcg gccctgccgc tggacgggat ggacgcggac
     7501 tccgcccgcg tcgcggtcga cgaggccgcc gaccgcctcg gcggactcga catcctggtc
     7561 aactgcgccg gcatcttccc ctacgggttg atcgaggacg tcacgctgga gcagttcgac
     7621 caggccatcg cggtgcacgt gcggaccgcc ttcctgacga cgcaggccgc ggtgcggcac
     7681 atgtccggcg gcggccggat catccacatc ggaacctcgt tcgtggaacg ggtgccgttc
     7741 cccggcgtga gcctgtacac cttgagcaag tccgggctca ccggtttcgc caaggcgctg
     7801 gcccgggagc tcggcccccg cgggatcacg gtcaacgtgg tgcacccggg gcctacggac
     7861 acggacatga acccggcgga ttccgaaggg gccgacgggc agcgcgccat caccgccctg
     7921 gggcactacg gcgtggtgga agacatcgcg aacaccgtcg tgcacctgtc cggtgccggt
     7981 gggcgccaca tcaccggtgc ctcgatcccc gtggacgggg gatgggcggc ctgattcgac
     8041 ggccggtgcg cagcgggctc cgccgaccgt gcaacggtgc ggagaaccgg gggttcgtgg
     8101 gagaagtcag cgctgctgct gaggcagcgg cactggggca tcactagcac tgggcattca
     8161 ctgggtcatc actactgggg cgagttccat cgagccgggg tgcgcccgaa accgcaccac
     8221 cggccgagta cgggcccaag gctctggggg cctgatcgcg ttccgggcct gcgcggcccg
     8281 agcaccgcgg ttcacgggcg agctcgtcgg caattctcgc gcgcagcgcc ctgggggtcg
     8341 ctgcactgga ctgaagaggt atttctgcaa tggcaacaat ttcaaaagaa gcgcggcagt
     8401 acccggacct gaccagcggg tacaaccagc ggtggtcggg gactccggaa tccgttgtcc
     8461 tggtcgagtc cgtggagcag gtcgcaccgg tggtgcagga agccgtccgc gacggcaagc
     8521 ggatgacggt gaacggtgcc gggcactgct tcgaggactt cgtctacaac agcgacgtcg
     8581 atgtcgtgat caacatgaag cacctcgacg ccgtgtacta cgacccggcc atgaacgccg
     8641 tcgccgtcga agcgggttcg aacctgctca acgtgtacaa gaagctctac gagcggtggg
     8701 gtgtcaccct ccccggcggc ctctgctact cggtcggtgt cgggggacac gtttccggcg
     8761 gtggatgggg cgcgctggcc cggcggcacg gtttgatcgt tgaccacctc tacgcggtcg
     8821 aggtcgtcgt ggtcggcgaa ggcggtgagg tccgccgggt agtggccacg agggaggaag
     8881 acgaccccaa ccgggacctg tggtgggcgc acaccggcgg tggcggcggc aatttcggcg
     8941 tgatcacccg ctactggttc cgcagtcccg gcgcgaccgg ccgcgaaccc ggcgagatcc
     9001 tgccgcgccc accgcggcac gtgctgctca gcgcagccgc gctgtcctgg gacgagatca
     9061 ccgaagcagg cttcacccgg ctcgtgaaca actacgccga ctggcacgtg cgcaactccc
     9121 ggccgggcag ccgggccgca ggtctgttcg ggctggccgt gctcaaccac cggtcgaacg
     9181 ggcagatcgg cttgatcacc caggtggaag ccgatctgcc gggggcggac gacctgctag
     9241 cggaatacct cgacgcgatc acggacgggg tcggtgcacc gctccaaccg atgaccgcgt
     9301 cgatggggga gtacaacgcg atgcccgggt gctacgaagc gcagcgcttg ccgtggctgc
     9361 aggcgacgcg cttcctgggc accaacaacg tcgacctgaa caatccgacg ttgcgcgccg
     9421 attacaaatc cgggtacatg cgcggcaact tcccggacaa gcacgtcgcg accatgtacc
     9481 agagcctcac cagcaccgac atcgacaact cgaccgccac catgcacctg cagggcttcg
     9541 gggcccaggt caacgcggtg cccgagtccg cgaccgcgtt cgcgcaccgg agttcgttct
     9601 tcaagctcta ctggcaagtg ctgtgggacg acccggcgga tgacgacgag cacctgacct
     9661 ggttgcgccg gttctacgcg gacctgtacc gggacaccgg cggggtgccg gtgccgaacg
     9721 agctcacgga cggctgctac gtgaactacc cggacgtgga cttgaactcc gcggagcaca
     9781 accagtcgca agtgccctgg taccggctct actacaagga gaactacgag cggctgcagc
     9841 aggtgaagaa gcggttcgat ccgcgcgacg tgttccggca cgcccaatcc gtgcggctgc
     9901 cggactgatg ggacaggccc gtaccggtgc ggtgcgatcg ccctggtggc gcatcgcacc
     9961 gcaccggtcg cggggccggg catcgccgcg tggccgcgca tcagccgttc ttcgccagct
    10021 cagccagcga ctcgcccgcc acctcgagtt cccgctcgtc gacgtcgtcg acgaaccggg
    10081 cggccccgat gccgacggga agcggcaacc gctgcctgcc gccgcggtgt cgggtggtgt
    10141 cgcccagcgc cgagatcagc agctcgctgg tgcacagcgg gtgcgagatc ggcagttcca
    10201 gcgcgcgcat gagccgcagc acgcggctcc gttcggtagc ggtgaccaga cctcgcgctt
    10261 cggcgagcag cgtgctcaag gccatgtcga tgctcaccgc ttcgccgtgc agcagttccg
    10321 gcaacgcccg catctccagc gtcgggctga acgaatgacc gtagtcgacg acgcgttcca
    10381 gcgagctctc ccacaggttc ggctgcaatt cgtccaacat gccgccgatg gaccgttcga
    10441 gaacttcggt cgcggcttcc cggtgccggc cgtcgcgctg gaacttggca gcgaggagcc
    10501 cggcaccgtg ccagtccagc aggtcgaaca gccggcgatc cccgatcagc gccatcttga
    10561 ggatctcggc cagcccgttg ctgagatgcc tgcggtcgac ggttcgcagg aacgccggat
    10621 ccagcacgac gcgatcggcc gcgtgatagg tcccgatccg gttcttgtgc tcgtcgaagt
    10681 tgacgccggt cttcactccg atgcccgcgt cgacgagacc gatcagcgtc gtgggcaccc
    10741 gcaccaccgg cgtgccccgg cggtacaggc tgccggcgaa accgacgacg tccagcagca
    10801 caccgccacc cgccgcgacg atcggctcgt tccggcggtc gatgccgaac cgatcgagcg
    10861 cttgcagcac ggtgcgcacg ttgccccagt gcttcgtcgt ctcgtcgcaa tccagcacgc
    10921 aggtggcgga cgggatcgaa tgccgctcga agtagtcggt gaacgaacgg ccgtagtgcc
    10981 ggtgcacctc ggaatcaatc acgaggagtc gtcgcgccgt tggcggcacg ccgcgcggaa
    11041 cggcccgcag cagcgccgga ttcgcgggat cgagaatgcc gtcgcagagc gcgacgtcgt
    11101 agctgacggg ccgggtcgcc gttacggtcc agcggttgcg ggatgcttcg gatcgatccc
    11161 gccacggcgc gaacgattcc gttgcggtcg gcgtcatcta acgctccttc tctgtcaggt
    11221 tcgcgccggt gttccgggac gggtgcggat cgccggccgc attcgcgtcg gcgctgctcg
    11281 ggatcgcgtc gcggttttgc tcggccctgt tgtcccagcg tggggccggt ccgtacttgc
    11341 gtgcggcggt gcgctgttcg tagggcattc ccgcgggcat gtcgaccact tccagctgca
    11401 ttccccacgg cgcggtgaag tacatccacc tgttcccggc gagcgggcct tcttcgatcg
    11461 tttccggttc gccctgcaac cgcacccccg gctggttccg caggtattcg gcggcgacgt
    11521 ccacgtcgtc gacgtaaatg gccaggtggt gaccgccgtg gtcgctgttc tccggtatcc
    11581 ggcgctgctg gttcggggcc gtgtactcga acagttccag gttggtggtg gggcccagcc
    11641 gcagcatcgc gatccgggcc gtcgctcgtt cgtgcacgtt gagcttgcga gtcatccagt
    11701 caccggccag gtcctggacc ggaccttccc agtagatcgt ttcggcaccc agcacgtcca
    11761 cgaagaagtc gaccgcccgc tgcagatcgg gcacggtgaa ggcgacgtgg tcgacgtttc
    11821 gcgctccggg gattccgcta cccatcgccg gcccccgcgg gccgttccac gggtttccgg
    11881 atcggcaacc ggccggtcac cgattccggg aaaaccgcga tcagcagcag ttccaattcg
    11941 gcctcgccgg tgttgcgcaa caccgtgccc gaacccgcgg gcgcgagcac cagcgccccg
    12001 ggacgcaggg gagcgggccg gtcccgccgg gtatcggaca gctcgccgct cccgccgagc
    12061 accagcaccg ccagctcgac accggactgc ccgcgcgcgt cctgcgctgc cccgggcgcc
    12121 agcagcaagt agtccacggc ttcgcattcg ctgtagagca ttccgcgccg agccaggcaa
    12181 cgcgatctga tcacgccggt gcgctcgtcg gcggtcagca ccagtccgcg cgagtcggtg
    12241 acgatcattg ccggcctccc gcggcgccgg ggacggcgag gctcacgacg aacagttcca
    12301 gcggttcccg ctgggacgcg gcttcgatgg aaaccgttcc gccgagcggc agcgtcaggc
    12361 ccactccgga gcggagcgcg accgtttccg aggatccgcg tgcgcgtccc tggccgccga
    12421 tggtgtagac ggtgtgctct tcggagtcgg cggaaagctc cagcggctct ccagggcgca
    12481 ggcgcaccag ccgcgcgagc cgcagcggac cggtcaggtg ctcggtggtg tccacttggc
    12541 ctgcctggcg cagatcgatg accacggcgt cgctcattgc tgtcctctcc ggctcgtgtc
    12601 ggggtgtttc tcgcggggtg tcgagcaccg ccgcggtgtg cggtcccgag acttcgatga
    12661 ccagccagac cagttcctcg tcaccggtgt tgcgcaagcc gtggcgggtg cccaggccgt
    12721 tcacgatgag gtggcccggc cggacctggt gcgtccgtcc gttgagcgtc atctctccgt
    12781 cgccggagac gatgaagtac aactcttcgg tgcgcgaatg aatatgttct ccgctcaccc
    12841 cgcccggcgg tagtgcggac cactcgaccg cctcccagta gccgaacaaa ctgcccctgc
    12901 gagccagcac tttccagcgg gccaggcctt cgccgctgtg cattccgtgg atgtccgacg
    12961 gttcgttgag gtctgcgacg atcactgcgt ctaccaagga tcgttccctc cgtgtacgag
    13021 cgtgcgaaaa cggcggaagc gtgaattggg tggcgcttcg ccacgcggtc gggccagaag
    13081 tgtcgatcga tcgcacacgg cgcgctgcgc tgcgttccgc ggtggaccgc gcggccctga
    13141 ttccttcccc agtcccgcac atcccgagat gtccggtgtg ctgccgagtt tggggcgggg
    13201 cacccggtgt gtcaagcgaa atgcggctcc gcgaccgctt cccgctccga tttcacattc
    13261 gcaccggggc cgatcggttg tcgtttggtg ctaacggctc acgtgcgcgc ggtggatttt
    13321 ccggcggctt ccgctgtgca ggtgaataat tgctctgaag cggtgaacgg caaccggacg
    13381 gatccgatgc ccggacgcaa ggagttcttg tcgaaaaatt gcggcagtgt cctgaatcac
    13441 attacgatct tcgatttgcc gccgctaaca tcggcggcat cacccgtgcc atgggggttt
    13501 ccgggtgcat tccgatgatc cgcgccgaag cgattcgcgg ggccttggcg cgcccgcggc
    13561 atcgtccgat tcggtgcgcg gtccgcgaac atcgaaggag tcgccctgtg cgagtacagg
    13621 tcgaagtgac gtccgcgctc caggactaca tcgccgaaat gtccttgcgg gaacccgcgg
    13681 cgctggccgc gctgcgggag gagacggagc agatgcccgg cgcgatcatg caggtctcgc
    13741 cggaggaagg ccagttcctc ggggtcctgg tgcgagcgct cggtgcttcc cgcgtgctgg
    13801 aagtgggcac gttcaccggg tacagcacga tctccatcgc acgcgcgttg cccgccggcg
    13861 gcagcgtgct ctcctgcgac atcagctcgg aggccagctc gatcgccctg gcgcacgccc
    13921 gccgggccgg cgtcgaggac aaggtcgacc tgcgggtcgg tgacgccgtc ggggtcctca
    13981 ccggactcac cggactcgcc gggcgcgcgg accggcgcgg ctccttcgac ctggtcttca
    14041 tcgacgccga caaggagggc tacgcggact actacgagat cgcgctgcgc ctggtccggc
    14101 ccggcggact gatcttggtg gacaacgtgc tgtggcacgg cgccgtgctc gacgaggccg
    14161 aacaggacag cgagaccacg gcgatccgcg cgttcaacga gaagatccgg gaggacgagc
    14221 gggtggacct gagcatcctc ccgttcgccg acgggctggc gttcgcggtg aagcgctgac
    14281 cagccgggat cgaggagggg cgggatcgag gaggggacgg atggtcgtcc ggtcgaaaga
    14341 ggtctacgac aacccggtct gcggtgagcg cgtcgtcatc cggcggggca acgacgaagg
    14401 cgacgggtcc gtgctcatct gggacctgta cctggagccc ggcggcaccg tggtcggcga
    14461 gcactaccat ccgacggccg acgagaggtt cgtgctggtc agcggcaagc tgggcattcg
    14521 ggcaggcggc cggtcgcggg ttctcgaaga agtgggcgag agcgtgctcg ccgaagcggg
    14581 cacccggcac tacttctgga acggcgactc cggcccgacg cggatcgtga tccggatgca
    14641 gggccgggtg gatcgcttcg agcaggccgt gttccggcag ttgtacgggc tggcccaaga
    14701 cggcaggacc gattcgaacg gcaagcccgg cctgctgcag catgcggtga cctccgccga
    14761 atacgccgac atcgtccggt tcgccgcacc gccgtggccg gtgcagcgct tgctgttcgg
    14821 ggtgctcgcc ccggtcggac gtgccctcgg ttatcgggcg ttgtgcgcgg agtaccggga
    14881 ccggcgagcg ccgctcgtcg cggaactcga cccgctgccc ccgggatttc ccgagttgta
    14941 gcggtgccgc tgctgatgtc ccggcctcac gccaccaccg gcgtccccgt cagcgccact
    15001 cccgccgcgc ggaggtcgcg aacagctgtg tccactgtgg ccggtgcgac tcctgcggtc
    15061 agcgacagca ggaccgtcgt ggtcaggccc gctttcgcgg cgtccagcgc ggtggcgcgc
    15121 acgcagtggt cggtggcgat gccgaccaca tcgacggcgt ccactccgcg ttcaccgagc
    15181 caatcgcgca gcggcgtgcc aagccgatct ttcccctcga aaccggagta tccggcgctg
    15241 tactgcccct tggagaacac cgcgcgcacc ggccccacct ccagctccgg gtggaacgcc
    15301 gcgccggccg tccccgcgac gcagtgcacc ggccaggacc gcacgtagtc cggctgcgag
    15361 ctgaagtgat ccccgggatc gacgtggtag tcgcgggtgg cgaccacgtg tgcgtactcg
    15421 ttctccgcgg catggcggga aatcgccgcg gcgacaccgg ccccgccgga caccccgagc
    15481 gccccgccct cgcagaagtc gagctgcaca tcgacgatca gcagcgcagt gctcatccgt
    15541 gctcctccac tcggctcgcg ggggatcagc tctccggaaa gacggtcgga atcgccggtt
    15601 cgccaccgga aagcttcagc ccctcccacg gcaggctcac cagtgcgtgc cgcaggcgct
    15661 cccgattgtc ctccagcgtg ggcaggtcat cgacctgttt cccgccgcgc accagtggaa
    15721 tcggcacctc gcggtcgtgc gggcccggct gcggcgcggc gaagcccgac ccggtccggt
    15781 acacctcctc ctcgatcgcg gtaccggtgt tcttgtgcct gcgcagcgcg gatttgctgc
    15841 cgccgcggga ctccttgctc gacgagcgct tggcgaccgg gcggccctcg acctcggtga
    15901 gcttgtagac catgcccgcc gtcggcgccc ccgaaccggt caccagcgaa gtgcccacgc
    15961 cgtagccgtc gaccggttcc gcgcgcagcg acgcgatcgc gtactcgtcc aggtcaccgg
    16021 agacgaccac gcgggttccg gtcgcgccca gcgaatccag ctgctcccgc gcctgccgcg
    16081 ccagcacgcc cacgtcaccg gagtcgatcc ggaccgcgcc gagaccggaa cccgcgacct
    16141 ccacggccgt cgcgatcccg cgggaaatgt cgtaggtgtc caccaggagt gtcgtgtccg
    16201 cgccaagagc ggcgatctgc gactcgaacg cggcacgctc ggagtcgtgc agcagcgtga
    16261 acgaatgcgc cgaggtcccc atggtgggaa tgcggtagcg gcgaccggcc tccaggttcg
    16321 acgtcccgga gaaccctgcc aggtaggcgg cgcgtgcggc ggccaccgcg gattcctcgt
    16381 gcgtgcggcg ggatcccatc tcgatgatcc ggcgcccgtt ggccgccgag accatccgcg
    16441 cggccgcggc ggcgatcgcg ctgtcgtggt tgaggatcga cagcaccacc gtctccagca
    16501 gcaccgcttc cgcgaacgtg ccgcgcacgg tcagcagcgg cgaaccgggg aagtacagct
    16561 cgccctcggg ataaccgtcc acatcgccct ggaaccggta gttgcgcagc cagtccagcg
    16621 tggtctcgtc gaccaccccg gcctccgcga gccgcgtcag ctcggcctcg tcgaagcgga
    16681 agttctcgat cgcgtccagc acccgctgca ttccgccgag cacgccgtac cggcgcccgt
    16741 ccggcaatcg ccgggtgaac acctcgaaca cgcaacgccg ctcggcggtc ccgtcgcgca
    16801 gggcactggc cagcatggtc agctcgtagt gatcggtgcg cagtgcggta ctggatgcgg
    16861 ccgtcatgga tcagaggcta cgtgccgccc gcgcggttcc cgcacaggtc gggccgggtg
    16921 tgcccgtgcg gtcgacacgg ttcccgcgca cacgtgcgaa catggggaca tgacttcgcc
    16981 cgctgaactg gagcgcgcgc agccgaacga actcggcaac gaggacaaac cgtgggtgac
    17041 cgtggtgtgg aacgacccgg tgaacctgat gtcctacgtg acctacgtgc tgcagaagat
    17101 cttcggttac agccgggacc acgcgaccaa gctgatgctc gacgtgcacc acaagggacg
    17161 ggccgcggtg tcctcgggca cgaaggagaa ggtcgagggc gatgtggcga agctgcacgc
    17221 caacggcctg tgggcgacga tgcagaaaga ctcgtgatct caagtgaacg gctggacgcg
    17281 caagaacggg cacgtcgtcg ccgaactgtc tcagcaggaa gcggcggtga tccgcggcct
    17341 ggtcgggcag atcaaggaca tgctcgacgc ccgggccgac gaggccccgc aggacgagct
    17401 ggccgagctc accggcatcc gcaccggccc gtccaccccg cccgaggacc gggtgctgga
    17461 gcggctgctg ccggacttct accggcgcga cccggaaacc ggcgagaccg acgaggagaa
    17521 gcccgcggcc gccggggcga tgcgctcgct gtacgagccg gagctgctgg accgcaagac
    17581 gggcaccgcc gcggtggtgc tggagacctg cccgcgcgac ggcggccggg tggtgctcag
    17641 cggtgagcag gccgacaact ggctcagcgc gatcaacgac gtgcggctgg cactgggcac
    17701 cgccctcgac gtgcaggagg acatgcccga ggagccgccg gaggacgacc tgcgccgcga
    17761 gcacctgggc gtctaccagt ggctcacctg ggtccaggac tccctggtcg aaaccctcac
    17821 ctcctgagcc gtttcctcca ggagtgaacg gaccgttgga ccaatctagc cggaccaaca
    17881 ggccgttcac tcggtccact tcgcgcaggg cgagtggtgc gcgggtgttc gccagagcgg
    17941 cagagccggg gttcgcgaag agtgaacgga ccgtttgccc aatctagtgg gacgaacagt
    18001 ccgttcactc gggaaagccg ggggtgaagc cgcggtgcag atcgggcagg gtcgtcgcat
    18061 gcgatcagga gcgcggaact cgatcaccga cgtgcgcggc gtgctcgtgg ggcacgagca
    18121 gcggctcgac gagcagtggg cgaccggtac cagcgtggtg ctcaccgcgg gcggcgcgtc
    18181 cgcggcggtc gacgtgcgcg gcggcggccc cggcacccgc gagaccgatg tgctcgaacc
    18241 gacccacgcg gtgcagcagg cgcacgcgat cgtgctcacc ggcggcagcg cctacgggct
    18301 ggccgccgcc gatggcgcga tgcgctggct cggcgaacgc gagcacggtt tcccggtggg
    18361 caccgagccg cacgagatcg ttccggtcgt cccggcggcg gtgctgttcg acctgccgat
    18421 gggcgactgg ggcaaccggc cggacgccgc cttcggccac cgcgcctgcg atgcggcctc
    18481 ggccaccgag gctcgggagg gcaacgtcgg cgccggaacc ggcgcggtcg cgggctcgct
    18541 caagggcggc accggttccg ccagcgcggt gttcaccagt gacgtgctgg gcagcgaggt
    18601 caccgtcggc gcgttgatgg ccgtgaactc ctcgggctcg gtgatcgacc cggagaccgg
    18661 gttgccctgg aacccgcatc cgggcctgcg cgccccatcc gccgacgaga tcgcggcggg
    18721 caagcggctc ggcccccggc cgtcgcggca cgggacggcg cagcgcccgg tgaacaccac
    18781 catcggagtc gtcgccaccg acctcgcgct gaccaaaccg cagtgccacc ggatcgcggt
    18841 cgccgggcac gacgggctgg cgcgcgcgat ccggccggcg cacgggatgt ccgatgggga
    18901 caccgtgttc gcgctgtcga ccggttcccc cgcggcgtcc agggaacggg attccgatca
    18961 gcggctggcc ggtgccgagg cgcggctgct cgacgaggtc tgcgccgccg cggccgacgt
    19021 cgtgcagcac gccatcgtgc gcgcggtgct ggccgcggaa ccggtgggcg aggtgacttc
    19081 ctacacgcgc acctacccct cggcgcggga atgaaccatg gttggcggac gttgatcccg
    19141 ccgaacggca ccggccgggg gcgtggcctc ccggatcgtg ggacaccggt gccccacata
    19201 gtaggatggt gcttgtgctg gtgattcgac gcgacctcgt cgacgcgatg gtcgcgcacg
    19261 ctcgacggga ccacccggac gaggcgtgcg gcgtcattgc cggcccggac gggtcggacc
    19321 ggcccgagcg gttcgtcgag atgatcaacg cggagcgctc gccgacgttc taccgcttcg
    19381 attcgagcga gcagctcaag gtgtggcggg agatggacca ggccgatgag gagccggtcg
    19441 tcatctacca ctcgcacacc gcgaccgagg cgtacccgtc gcgcaccgac gtgtcctacg
    19501 ccttggaacc caatgcgcac tacgttctcg tgtccaccag ggacccggag acccacgagt
    19561 tgcgctcgta ccgcatcctc gacggcgtgg tgaccgagga gccggtggag atcgtggagt
    19621 cctacatgtt cgcccacacc ggcaccgacg aggtgcccga ccgcggctga gccgcgctcg
    19681 ccgcagtcat tcggcgagcg ggcgtgtgca agttccgttc agtagttcct gtggacaggg
    19741 aggtaccccc atggcaatca acgtctcgat ccccaccatc ctgcgcaccc acaccgatgg
    19801 ccagaagtcg gtggaggcca gcggcaacac ggtcgccgag gtcatcaacg acctggacag
    19861 caagcacagc ggcctcaagg accggctggt caaggagggc tcgctgcacc gcttcgtgaa
    19921 cgtctacgtc aacgacgagg acgtgcggtt ctccggtggc ctggaagcca gcgtggccga
    19981 cggggacagc gtgacgatcc tgccggccgt ggccggcggc atgcgctgag gcggaggcga
    20041 acgtcgtggc ccgctacgac tcattgctcg acgcgctcgg cgacaccccg ctggtcgggt
    20101 tgccgcacct gtcacccgca ccggacgtgc ggctgtgggc gaagctggag gaccgcaacc
    20161 cgaccggttc ggtcaaagac cgcgtcgcgc tgtccatgat cgaggcggcg gagaaggaag
    20221 gccggctcac caccggctgc accatcctgg agccgacctc cggcaacacc ggcatctcgc
    20281 tggcgatggc cgccaagctc aagggctacg gcctggtgtg cgtgatgccg gagaacacct
    20341 ccgaggagcg caggcagatc ctgcaggcgt tcggcgcgcg gatcgtgtcc tcgcccgccg
    20401 cgggcggctc gaaccaggcg gtcgcggtcg ccaaggagct cgcccagcag aacccggact
    20461 gggtgatgct ctaccagtac ggcaactccg cgaacgcgga cgcgcactac cgggggaccg
    20521 ggccggagat cctgcgggac atgccgggcc tcacgcactt cgttgcgggg ctcggcacca
    20581 cgggcacgct cgtcggcgtg gggcgctacc tgcacgagca caagcccggg gtgcagatcg
    20641 tggcggccga gccgcgctac ggcgagctgg tttacgggct gcgcaacctc gatgaggggt
    20701 tcgtgcccga gctctacgac gagagcgtgc tgtcccgccg gttctccgtc gggtcctacg
    20761 acgcgctgcg gcgcacccgg caactgctgg agtccgaggg catcttcgcc gggatctcca
    20821 ccggcggcgt ggtgcacgcg gcgttgacca tcggcgagaa ggcggccgcg gccggggagt
    20881 ccgcggacat cgtcttcgtc gtggccgacg ccgggtggaa gtacctgtcc accggcgcct
    20941 acggcggcac cctcgacgag gcggcgcaac gcctggacgg ccagctctgg gcctgatccc
    21001 gccgcccgca tttcttcgca aggcccaccc gatccgctcg ggtgggcctt gcgttttcgc
    21061 cgtgccaggt gctcgctgca atgcgcgttg actttgcggc gacgggacgt gccaacgtag
    21121 ctgcatgttg cgcgtgagtg agcagacccg tgagcgggtc cggcagctgg cacaagagga
    21181 attcggcggc gtcagcg
//
