LOCUS       NZ_JADDUE010000010     21544 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Saccharopolyspora sp. HNM0986
            NODE_10_length_275939_cov_68.081565_cov_68.081565, whole genome
            shotgun sequence.
ACCESSION   NZ_JADDUE010000010
VERSION     NZ_JADDUE010000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Saccharopolyspora sp. HNM0986
  ORGANISM  Saccharopolyspora sp. HNM0986
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (bases 1 to 275939)
  AUTHORS   Li,F.
  TITLE     Diversity and distribution of actinomycetes associated with coral in
            the coast of Hainan
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 275939)
  AUTHORS   Li,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2020) chool of Life and Pharmaceutical Sciences,
            Hainan University, 58 Renmin Avenue, Meilan District, Haikou, Hainan
            570208, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 232.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016526145.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 02:15:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,899
            CDSs (total)                      :: 5,838
            Genes (coding)                    :: 5,784
            CDSs (with protein)               :: 5,784
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 7 of 54
            Pseudo Genes (incomplete)         :: 49 of 54
            Pseudo Genes (internal stop)      :: 0 of 54
            Pseudo Genes (multiple problems)  :: 2 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:09:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 124325
            Orig. end                         :: 145869
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADDUE010000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21544
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="2"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21544
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21544
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11544](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11544)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            complement(355..1716)
                     /gene="mftF"
                     /locus_tag="INP57_RS22295"
                     /old_locus_tag="INP57_22300"
     CDS             complement(355..1716)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152863.1"
                     /locus_tag="INP57_RS22295"
                     /note="Members of this protein family, MftF, are
                     glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969).; Members of this protein family, MftF,
                     are glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969); Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22300"
                     /product="mycofactocin biosynthesis glycosyltransferase
                     MftF"
                     /protein_id="WP_233628063.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.1e-14,
                     bitscore: 47.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDLPAGTRLVPDPSLRRLGDGRVLLGGSPLRLLRLGAAGSRLV
                     NRWLSGEPVEPGAASELARRLLESGLVHPEPARKIWTEDDITLVVPVKDDRAGLRLALR
                     AATDIPNRIVVDDGSTSPVPDSTVRHEHPRGPAAARNTGWRRAETELVAFVDADAEPVA
                     GWLDPVLREFTDPAVLAVAPRITSVAEDSPLGRYESDRSSLDMGVRRALVRPMSRVSYV
                     PSAALVVRRSALAGLGGFRESLRYGEDVDLVWRLLESGGAVRYEPGSVVRHRTRPGWRS
                     WLRQRYQYGTSAAPLSRHHHGKLSCARMSAWSAASWALIASGRPRIGLGVAAVSAALLP
                     RKLRARGVPDAESLRLAAFGHLGAGRLLAEALRRAWWPLLLPAALCSGKARTVLLAAFL
                     PCLVEACRAEHGGFSWFALRVLDDLAYSAGVWVGCARERTIAPLLPQFTEGSLR"
     gene            complement(1713..2501)
                     /locus_tag="INP57_RS22300"
                     /old_locus_tag="INP57_22305"
     CDS             complement(1713..2501)
                     /NRPS_PKS="Domain: PKS_KR (5-179). E-value: 2.2e-10. Score:
                     32.7. Matches aSDomain:
                     nrpspksdomains_INP57_RS22300_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983860.1"
                     /locus_tag="INP57_RS22300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22305"
                     /product="mycofactocin-coupled SDR family oxidoreductase"
                     /protein_id="WP_200072259.1"
                     /transl_table=11
                     /translation="MGEPRVALVTGAARGIGAAVVRRLAGSGWRVVALDRCADDPRVDY
                     PLGTPEQLSALAAEFQGSVVDVAADVQDPDALRRAVELAEQRFGGLDAAVGAAALMAGG
                     RPFWEAGEREWDALFSVGVDGSANLAKAAVPALLRRPEPRTGRFVALASAAAHQGLWRL
                     TSYNAAKHAVVGLVRGLATDLRGTGVCATAVSPGSTRTDMLDASAGLYDLSDVDEFAGH
                     QLTERILEPDEVAAVVAFLCSPDSSAITGTVVHADGGFTA"
     aSDomain        complement(1965..2486)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_INP57_RS22300_PKS_KR.1"
                     /evalue="2.20E-10"
                     /label="INP57_RS22300_PKS_KR.1"
                     /locus_tag="INP57_RS22300"
                     /protein_end="179"
                     /protein_start="5"
                     /score="32.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGAARGIGAAVVRRLAGSGWRVVALDRCADDPRVDYPLGTP
                     EQLSALAAEFQGSVVDVAADVQDPDALRRAVELAEQRFGGLDAAVGAAALMAGGRPFWE
                     AGEREWDALFSVGVDGSANLAKAAVPALLRRPEPRTGRFVALASAAAHQGLWRLTSYNA
                     AKHAVVGLVRG"
     CDS_motif       complement(2406..2480)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_INP57_RS22300_0001"
                     /evalue="2.50E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="INP57_RS22300"
                     /protein_end="32"
                     /protein_start="7"
                     /score="10.5"
                     /tool="antismash"
                     /translation="LVTGAARGIGAAVVRRLAGSGWRVV"
     gene            complement(2494..3357)
                     /locus_tag="INP57_RS22305"
                     /old_locus_tag="INP57_22310"
     CDS             complement(2494..3357)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04503.1"
                     /locus_tag="INP57_RS22305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22310"
                     /product="mycofactocin-associated electron transfer
                     flavoprotein beta subunit"
                     /protein_id="WP_200072260.1"
                     /transl_table=11
                     /translation="MLIVVAMRCTDAHASVRPLSGEVHADPRMAGPSPADHAALESGLR
                     LAERTGGRCVVVTQAPVAAEDVLREALSCGANEVLRVDSGAEPDERAADSGAGTAKSLA
                     GAIRARFGVPDVLLTGDHSIDRGTGATPAFLASEMRCAQALGLVSLETTGTDEGGRLRG
                     VRRLDRGRRERLAIPLPAVCSVEPAGVRLRTATLPATLAARSAEIPVHQVAAEPAALRV
                     RAASGYRPRAKELPPPAGSEARQRVLELTGAHEQREPPRIVTTDDPAEAAEELVSFLRD
                     KGYLDG"
     gene            complement(3364..3660)
                     /locus_tag="INP57_RS22310"
                     /old_locus_tag="INP57_22315"
     CDS             complement(3364..3660)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152866.1"
                     /locus_tag="INP57_RS22310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22315"
                     /product="ferredoxin family protein"
                     /protein_id="WP_200072261.1"
                     /transl_table=11
                     /translation="MTERYRDVSFEERMSHVDFRVSEQPHIVVDTDVCRSCTTRACVHA
                     CPANLFVPTDDGGILFNYEQCFECGTCYQVCDESGAISWEYPSGGYGVAFRKG"
     gene            complement(3681..5048)
                     /locus_tag="INP57_RS22315"
                     /old_locus_tag="INP57_22320"
     CDS             complement(3681..5048)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119: halogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027340.1"
                     /locus_tag="INP57_RS22315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22320"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_200072262.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.8e-08, bitscore:
                     26.9, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 6e-10, bitscore: 33.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPENNASGAGPAAGAVTISEPQDYDFDAIVVGAGPAGSAAALELA
                     RAGRSVALVERGPFPGSKNVYGGVVYGRVLDELLPGWYDRMPVQRWVTRRQTMLLGGDR
                     SMTVDFRTQNWGRAPYNGATTFRAEFDSWLAENAQEAGAVLVPSTVAASLLRTPDGQVR
                     GIRTDRPDGDLTARVVIACDGVNSFLGKQAGCFTGDQADHTTLGVKETLALPKATIDER
                     FGVTGSDGVDIEMLGATKGVPGGGFLYTNADSVSIGLVLGLRGLAKAKMRPEAILADLK
                     EHPSIEPLVRGGELVEYSAHLIPEGGYRTMPKLTADGLLLAGDSAGMCLAAGIWLEGVN
                     FALGSGMYAGRSAASALAAGDTSASGLAGYRTSLEKSFVLGDHKKLRDAPGLVLSDRMQ
                     RQYPGMICDLVEGMFTVDNPRPKPGLRRLLRRSMKRNGVRVRDLAKDALTGLRSFG"
     gene            complement(5041..5988)
                     /locus_tag="INP57_RS22320"
                     /old_locus_tag="INP57_22325"
     CDS             complement(5041..5988)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152868.1"
                     /locus_tag="INP57_RS22320"
                     /note="Built with help from friend_finder, bracket5, and
                     grep mycofactocin; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22325"
                     /product="mycofactocin-associated electron transfer
                     flavoprotein alpha subunit"
                     /protein_id="WP_200072263.1"
                     /transl_table=11
                     /translation="MTRIESDVVAVLVVRDGIPPVGGDEAVAEAGGAAVLIGTGCAGAV
                     AELPIRRGWCAEAGPFAAGAFAKALASPLTDVPRILLPASPDGRDLAPRLAAELDRPLL
                     AGATRFTAEGTDLVRWDGRLGVQVDTPPACVATLVPGVRGALPFSGDREVTTVDVELQH
                     ADAEVLEVLEPDPATADLAESSRILGAGAGLARGELSGPDAIAALGELADALRASVGAT
                     RVVTDADWAPYERQIGTTGVVADPDLYIAFGVSGAAQHIGGLRDPRHTVSINTDASAPM
                     TAMADLGLVTPAQPLLAELVRRLANRSAGQEHHA"
     gene            complement(5985..7952)
                     /locus_tag="INP57_RS22325"
                     /old_locus_tag="INP57_22330"
     CDS             complement(5985..7952)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152869.1"
                     /locus_tag="INP57_RS22325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22330"
                     /product="mycofactocin system FadH/OYE family
                     oxidoreductase 2"
                     /protein_id="WP_200072264.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-13, bitscore:
                     44.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSASGRYKHLFTPLRLGPVTVRNRIVFSAHLTNYARNGLPSDQHA
                     AYYAERAAGGAGLIITEEHSTHPTDWPYEKLIHGFHPEAVDGYRKITEAVHAHGTPIFA
                     QLNHNGGQASSMYSRLPVWAPSAVPDPMFREVPKAVSHAEIDEIVAGYALVAGHCRAGG
                     FDGVELQCSHSSIVRGFLSPTTNVREDEYGGSLRNRARLLLRLVAAVREAIGPDLALGV
                     RLCGDELIEGGTTIDEAVEVARMVESTGAVDYVNTSIGVATSTLYMIEASMSVPPGYAM
                     FIPSALRKAVDLPVVGVGRFKDPVQADRALIEGHSDLIGVVRGQIADADFAAKARAGHA
                     TDIRTCLSCNQECVGRMGLNRWLGCIENPRTGKESVPLPMPGAGKRVVIVGGGPAGLQA
                     AATAAQRGHRVTLLERQETTGGQVSAAASVPQRAEFLDVVRNSLAECHRRGVDVRTGVD
                     ATGQSISELRPDVVVLATGARPQAPWWAGGLDRVVDVRDVLEGRAEPDGQVIVVDDLGF
                     HQATSVAELLADRGCSVRITTSGMVVGQDLGITLDMETFNARAAEKGIAQTTDEVVLGA
                     AADESTGGVRLQILRHTTGSNDEVPCDWVVCATHQEPEEALWHELSESDIFEVHRVGDC
                     ITPRRAHAAVVEGHRVAVGL"
     gene            complement(7949..9910)
                     /locus_tag="INP57_RS22330"
                     /old_locus_tag="INP57_22335"
     CDS             complement(7949..9910)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152870.1"
                     /locus_tag="INP57_RS22330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22335"
                     /product="mycofactocin system FadH/OYE family
                     oxidoreductase 1"
                     /protein_id="WP_200072265.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.7e-11, bitscore:
                     36.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPDPDAGTGLTGPIGLGGRTAPSRVLFGPHETNLADGRAISGA
                     HAAYYAERASGGAGVVVTEIASVHESDHPYERAPLATECVSGWSAVADACHPHGTLVLA
                     GLGHAGSQGSSAFSQSALWAPSRVADVASRELPMAMEMREIRALIGGFGDAAELAAESG
                     VDGVEVNAGQYSLLRQFLSGLTNQRGDAYGQDRALLVREVIGEIRSRMGSGMLLGLRLS
                     CDELAPWAGITEDQGKEFAASLAAEVDYLAVVRGSAMGASATTPDSHTEPGFNFALCGA
                     IREAVAGAAPVVLQGSVVEAEQAQVALDEGAADLVEMTRAQIADPGLVGKIRTGQRDRV
                     RPCTLTNQKCRVRDNRNPVVSCVGEPRSGHETTDTDVSPGSGGEPVVVAGGGPAGLEAA
                     RVLAMRGHSVHLVERNERLGGMLALAAFLPARERIGKLVDWLIGEVRRLDVQITIGEEA
                     DMEAQNLVLATGSSPGPRPYQVGEGAVVVDVVDLLRAVRDGDLDRAVPGGPVAVFDPVG
                     DATGVAVAELLAATGRETAILSQDQVIGTQLALTGDLADANARLQRAGVTMAKRSLLRA
                     VRGGAADIEDVFTGEHRSIAANSVIHCGHRVPVSSDAPERARTAGDRVAPRTAHEAILE
                     GRRAALSFARPRALVEAS"
     misc_feature    complement(9953..9968)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.43"
                     /tool="antismash"
     gene            complement(10001..11206)
                     /gene="mftC"
                     /locus_tag="INP57_RS22335"
                     /old_locus_tag="INP57_22340"
     CDS             complement(10001..11206)
                     /EC_number="1.3.98.7"
                     /EC_number="4.1.99.26"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007026927.1"
                     /locus_tag="INP57_RS22335"
                     /note="MftC is a radical SAM/SPASM enzyme that catalyzes
                     the first two steps in biosynthesis of the electron carrier
                     mycofactocin from the terminal Val-Tyr dipeptide of the
                     precursor peptide MftA.; MftC is a radical SAM/SPASM enzyme
                     that catalyzes the first two steps in biosynthesis of the
                     electron carrier mycofactocin from the terminal Val-Tyr
                     dipeptide of the precursor peptide MftA; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="INP57_22340"
                     /product="mycofactocin radical SAM maturase"
                     /protein_id="WP_200072266.1"
                     /sec_met_domain="PTHR43273 (E-value: 2e-41, bitscore:
                     136.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.9e-25, bitscore: 83.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.2e-09, bitscore: 30.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 9.6e-16, bitscore:
                     52.0, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.5e-06, bitscore: 21.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLVEHFQHGLDSPICLTWELTYACNLSCVHCLSASGRRDPRELS
                     TAECKAVIDELQRMQVFYVNIGGGEPTVRSDFWELVEYAVDHQVGVKFSTNGVRLGPER
                     ARWLANTDYVDVQLSLDGATAEVNDRVRGEGSYDTVLAAMDNLRAAGFSGFKISVVLTR
                     ENIDQLDQFKEIADSYDAQLRLTRLRPSGRGADVWDELHPTAEQQRQIYDWLVAHGEGV
                     LTGDSFFHLNALGSTPLPGLNLCGAGRVVCLIDPIGDVYACPFAIHSEFLAGNVRDDGG
                     FGSVWRESELFERLREPQTGGACTSCSAYDACQGGCMAAKFFTGLPLDGPDPECVKGNG
                     ERALAGVGAGVPKPDKDHSHRTRPREKKGGPVPVGIGWGPPEPEGIPDRACDTSPLAGF
                     RP"
     gene            complement(11239..11544)
                     /gene="mftB"
                     /locus_tag="INP57_RS22340"
                     /old_locus_tag="INP57_22345"
     CDS             complement(11239..11544)
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Mycofactocin_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010229645.1"
                     /locus_tag="INP57_RS22340"
                     /note="MftB, a small protein, is a peptide chaperone that
                     assists the radical SAM enzyme MftC in performing two
                     modifications to the C-terminal Val-Tyr dipeptide of the
                     mycofactocin precursor peptide, MftA. MftB's role is
                     analogous to the role of PqqD in the biosynthesis of PQQ, a
                     cofactor that derives entirely from a Tyr and a Glu in the
                     precursor PqqA.; MftB, a small protein, is a peptide
                     chaperone that assists the radical SAM enzyme MftC in
                     performing two modifications to the C-terminal Val-Tyr
                     dipeptide of the mycofactocin precursor peptide, MftA.
                     MftB's role is analogous to the role of PqqD in the
                     biosynthesis of PQQ, a cofactor that derives entirely from
                     a Tyr and a Glu in the precursor PqqA; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="INP57_22345"
                     /product="mycofactocin biosynthesis chaperone MftB"
                     /protein_id="WP_200072267.1"
                     /sec_met_domain="Mycofactocin_RRE (E-value: 3.4e-28,
                     bitscore: 91.8, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MACAASTDHGAAAGFDPGRPHRLSPNVSLRPERFGALVYDFSTRK
                     LSFLKTLELVAVVQELDGKPDVHSALAAAEVPAEQHPKYLEALAGLCSAGTIAPRD"
     aSDomain        complement(11254..11487)
                     /aSDomain="Mycofactocin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a mycofactocin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_INP57_RS22340_Mycofactocin_RRE.1"
                     /evalue="3.70E-29"
                     /identifier="RREFam016.1"
                     /label="INP57_RS22340"
                     /locus_tag="INP57_RS22340"
                     /protein_end="97"
                     /protein_start="19"
                     /score="91.8"
                     /tool="antismash"
                     /translation="PHRLSPNVSLRPERFGALVYDFSTRKLSFLKTLELVAVVQELDGK
                     PDVHSALAAAEVPAEQHPKYLEALAGLCSAGTI"
     gene            complement(11522..11620)
                     /gene="mftA"
                     /locus_tag="INP57_RS22345"
                     /old_locus_tag="INP57_22350"
     CDS             complement(11522..11620)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983865.1"
                     /locus_tag="INP57_RS22345"
                     /note="Mycofactocin is a small molecule electron carrier
                     derived from the final two amino acids, Val-Tyr, of MftA,
                     the mycofactocin precursor. It plays a role in redox
                     homeostasis and the metabolism of alcohols and aldehydes in
                     Actinobacteria, including Mycobacterium tuberculosis;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="INP57_22350"
                     /product="mycofactocin precursor MftA"
                     /protein_id="WP_200072268.1"
                     /transl_table=11
                     /translation="MSEAQADEPAPETVEDDLLVEEVSIDGMCGVY"
     gene            11701..12318
                     /gene="mftR"
                     /locus_tag="INP57_RS22350"
                     /old_locus_tag="INP57_22355"
     CDS             11701..12318
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0036042 - long-chain fatty acyl-CoA
                     binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="mftR"
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010229847.1"
                     /locus_tag="INP57_RS22350"
                     /note="MftR, the mycofactocin system transcriptional
                     regulator, is an uncharacterized TetR family DNA-binding
                     transcription factor. Its role is inferred by context. It
                     occurs as part of the biosynthesis locus for mycofactocin,
                     a partially characterized electron carrier derived from the
                     terminal Val-Tyr dipeptide of the precursor peptide MftA,
                     through a radical SAM enzyme-mediated process; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="INP57_22355"
                     /product="mycofactocin system transcriptional regulator"
                     /protein_id="WP_233628064.1"
                     /transl_table=11
                     /translation="MSAAAPKHPSGATPGPGRRRSTSPHELEQVAFDLFAGDGFEHTTV
                     DRIAQAAGIGRRTFFRYFDSKNDVVWGRFTEQLDLMRQRFSARPADEPLMDSVRAVVVE
                     FNRVDAAETERHRRRLELILRVPALQAHSTLRYAEWRAVVAEFAAQRLGIAESALIPQT
                     VAYAALGAALAAYERWLQEPGIDLCSVLDDALRHLAEGFSAV"
     gene            complement(12548..12880)
                     /locus_tag="INP57_RS22355"
                     /old_locus_tag="INP57_22360"
     CDS             complement(12548..12880)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS22355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_22360"
                     /product="hypothetical protein"
                     /protein_id="WP_200072270.1"
                     /transl_table=11
                     /translation="MGDAERTRNVRSAGRVLDFMASTKESLWHVAGMDAQGPAPTMLCG
                     HRLRGVVHRRLAALNEAQSPLVCAACWVSLHNRQEPGEPTGRHALQTGSDPPAAEPDPR
                     WPAAHF"
     misc_feature    12970..12988
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.35"
                     /tool="antismash"
     misc_feature    12971..12987
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.69"
                     /tool="antismash"
     misc_feature    complement(12994..13008)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.43"
                     /tool="antismash"
     gene            13071..13916
                     /locus_tag="INP57_RS22360"
                     /old_locus_tag="INP57_22365"
     CDS             13071..13916
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.4"
                     /locus_tag="INP57_RS22360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22365"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_200072271.1"
                     /transl_table=11
                     /translation="MSKFAGSQARAIGAEIRRSRDSLGWTLDRLANATDISRSTLSRIE
                     TGVRRPEVDEVASVLTALSVTGPAKDRLIRLAGDVSGTWVGVGDAVAQQLSAISAYEAE
                     AQSIYEFQVSVMPGLLQTPDYTRGLISTTPLGSAERERAVFNRVGRQSVLARPGLRYSA
                     FFDEAALRRRVKSHAGTMVEQLRALITVGGEEGRSVRVVPFSAGAYWGCESSFVFYGLG
                     GCHVVYLENQGSGVFIDGQSEDTYWKVLENLDNVALDAAESKALVTGYLEEYENELRVS
                     "
     gene            13897..14094
                     /locus_tag="INP57_RS22365"
                     /old_locus_tag="INP57_22370"
     CDS             13897..14094
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.5"
                     /locus_tag="INP57_RS22365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22370"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_200072272.1"
                     /transl_table=11
                     /translation="MNFEFRKSSYSAGGGAGTCVEVASNVPAVRAVRDSKEPEGAFLVV
                     SRDRFGSFLKSLRGGQFDRG"
     gene            complement(14182..14769)
                     /locus_tag="INP57_RS22370"
                     /old_locus_tag="INP57_22375"
     CDS             complement(14182..14769)
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016932.5"
                     /locus_tag="INP57_RS22370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22375"
                     /product="suppressor of fused domain protein"
                     /protein_id="WP_200072273.1"
                     /transl_table=11
                     /translation="MSDVTEDNRAIARAAAAEFGGKPSVTRFWDDQDSSAVDILECPDS
                     PTEGVTSCSTLGLSDHPLVRDGNEYPVRVEVVGAGATDNEHFPNIISTIAFFIINDQWF
                     CSPGSIFPDVVGMYYPAATMRHILFVPPFLWADELETMHFPGKTVAWLQAVPISEGERQ
                     YATANGSDALQDLFVQNQIDVFNLDRDSTVAE"
     gene            complement(14782..15969)
                     /locus_tag="INP57_RS30410"
     CDS             complement(14782..15969)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025767.5"
                     /locus_tag="INP57_RS30410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GH-E family nuclease"
                     /protein_id="WP_295141920.1"
                     /transl_table=11
                     /translation="MINPGAIPQIPGNMDALSAHANGLRTAGTGFADTGADVHSTWQGL
                     APAYLAPESEQLLQATRPVTETAGNVGRDVEQVAGALQRYADEVRPLQQHLRDLKAQAE
                     ALVADIHSYENQKPSTSELAASAKTGIVPDKDWTDDGDLTDRDAQLMSAVNQAVADWMA
                     AQRRCANAITGLYGGRHYTADNADGNRTGGEYGYSADQLTAAAGSDQGLPWGRTEDTSN
                     PLADIGHTALDLGGLIPGIGELADGANAAWYAAEGDHLNAGLSAAAMIPIGGWAATGSK
                     LAGKGAKAARTYKRPSGFRKNVRDTVWNDAEKAAPDGQVRDPSSNEVISKEEPWHMGHR
                     PGFEFRKHQSSAEERGITRKQFLDEHNNPDHYRPEKPQHNSGHRGEDHTDSYFGP"
     misc_feature    complement(15673..15675)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15966..16307)
                     /locus_tag="INP57_RS22380"
                     /old_locus_tag="INP57_22385"
     CDS             complement(15966..16307)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945177.1"
                     /locus_tag="INP57_RS22380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22385"
                     /product="DUF6507 family protein"
                     /protein_id="WP_200072274.1"
                     /transl_table=11
                     /translation="MEWDIHPEQVRGVLARTASTASEFDGHMTAMRSEMEGAAGQASSG
                     IIRQALAGFAEARGPDMQFVFSRIQSAIGGASTAVGAYLQGDHEMVRNAQRGVASAPDP
                     RAHMPGGRR"
     gene            complement(16362..16667)
                     /locus_tag="INP57_RS22385"
                     /old_locus_tag="INP57_22390"
     CDS             complement(16362..16667)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945176.1"
                     /locus_tag="INP57_RS22385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22390"
                     /product="pore-forming ESAT-6 family protein"
                     /protein_id="WP_200072275.1"
                     /transl_table=11
                     /translation="MSMDRRSFDTGISQSVQGDIQGIIGRLESVISQRDQAVAAAMADF
                     QADGVSDDYHHVEQRWKSAATEVRQIINLLKQTMAQNDDSANSAISRARSAVQGIG"
     gene            complement(16684..17016)
                     /locus_tag="INP57_RS22390"
                     /old_locus_tag="INP57_22395"
     CDS             complement(16684..17016)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945175.1"
                     /locus_tag="INP57_RS22390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22395"
                     /product="hypothetical protein"
                     /protein_id="WP_200072276.1"
                     /transl_table=11
                     /translation="MKFDMGSSTLSALTKQTQGSSDDLGALIRQLIAAAEPLEGKFNGA
                     GRAAFDSFKARADEITGELNGSLSAILGGQSGMDRSFGHGDTDMADNASANQGSANFDA
                     ARFGAR"
     misc_feature    17130..17140
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(17157..18389)
                     /locus_tag="INP57_RS22395"
                     /old_locus_tag="INP57_22400"
     CDS             complement(17157..18389)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010241331.1"
                     /locus_tag="INP57_RS22395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22400"
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_233628065.1"
                     /transl_table=11
                     /translation="MVAQAAHDAPPYPSRFFGAPERGRRIGRVLRLVARVRSLDEDLID
                     RIGRRMYSRDELGAQLVRAMRRDRADGERVRMAQFHQALEHGIESVPDAPEPLRKFFAE
                     VDQVPDWVDFDLLERGARTVRRMGRTTGDVLLQLALIGGYRFGGPADLLVETGGLTGST
                     ALRRLGETKKWAVAVTQPGAMHRDGEGFKLTVHVRAMHALVNDRFERNGRWDVQRWGLP
                     INQTDQASTLGLFNSTLLLGVRALGWVVTGEESRAVMHLWKYVGWLMGVDEDWLFDTER
                     EQNVFNYHILRVQDGQTPAGAALSSALVEGQLDVDHGRFGGVIGRYTRLRLLSMLRYFL
                     GKRDMRDLQLPVTPAWAVPGIVAANSVKSGLLGRTRRGRRYLERAGDRVVHRDLHKTFG
                     NGSPEIGALPA"
     misc_feature    complement(18408..18423)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.58"
                     /tool="antismash"
     gene            18435..19079
                     /locus_tag="INP57_RS22400"
                     /old_locus_tag="INP57_22405"
     CDS             18435..19079
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF036520.5"
                     /locus_tag="INP57_RS22400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22405"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_200072277.1"
                     /transl_table=11
                     /translation="MGTRMTARPRGQVRREPSQQRSRAMVERIITAGHAVLLEHGYERA
                     STGRIAAAAGISPGSLYQYFPDKHAVLTQVIDRYTDRLRTRISRAFVQNLAAPSPAESV
                     RGSVNALLDAFEANAGLIRVLYEQLPPTADTHRAEFKHRIDELVTTALLLHDRGRSGEP
                     IDAIAWVLVRTVENLTISYVLDPPPLGRETVVDELTRLITGYLADRIGRAG"
     gene            19118..19939
                     /gene="thiM"
                     /locus_tag="INP57_RS22405"
                     /old_locus_tag="INP57_22410"
     CDS             19118..19939
                     /EC_number="2.7.1.50"
                     /GO_function="GO:0004417 - hydroxyethylthiazole kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiM"
                     /inference="COORDINATES: protein motif:HMM:NF006830.0"
                     /locus_tag="INP57_RS22405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22410"
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="WP_200072278.1"
                     /transl_table=11
                     /translation="MPTIPDPEAVAGALARLRERTPLVHSLTNVVSANVLTNALLAAGA
                     TNAIIDNPREAGEFARIADAVLINLGTPDDEQARAFTAAAESAHAAGHPWVLDPVGVGG
                     LSWRTELAGGLLAHRPTAIRGNPSEIAAVAGLESTSRGVDSASDAAESVPAARTLLEVS
                     EVVSASGPIDYITGRTADGIATARVHGGSEWLPKITATGCALGALGAAYLAVAEPFTGI
                     VAAHAHFSVAAEFAEPHANGPGTFVPAFLDALAAVGPDDLRAHARIDSAEH"
     gene            20148..20873
                     /locus_tag="INP57_RS22410"
                     /old_locus_tag="INP57_22415"
     CDS             20148..20873
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF028519.5"
                     /locus_tag="INP57_RS22410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_22415"
                     /product="SdrD B-like domain-containing protein"
                     /protein_id="WP_200072279.1"
                     /transl_table=11
                     /translation="MRYSGLLLAAALPLAVAAPAQAADAGTGTVSGKYFMDRNGDGQQQ
                     ADEPGPHAGFVELLTTDGRQVAHGSPDEQGFYEFGDVAPGDYQVRFNEGGFLPTTPNNV
                     PVSVQDGGTAQADFGMQGGEISGMAWEDSNGDGQRQQGEPPIAGVEITSIDGAQYRATT
                     GEDGTYRIADAWINKDYRLTFQPREGMMFAPPRVGAPETDSDVIDADDGSAEASVWVGK
                     PGFIINAHNIDAGYVPPRG"
     misc_feature    complement(21315..21330)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.84"
                     /tool="antismash"
ORIGIN
        1 gttcttctgc cgagcgcagt gcgggcaggt tgccgccgtg gccgttgacc acgaccaccc
       61 ctgcgaaatg gtcggccgat cgcacgagtt cgaccagcag caggcggagg gcgtcgtgtc
      121 cgatggagag cgtgccgggg aaggctgcgt gctcgccgct ggcgccgtag gggatcgcgg
      181 gaccgatcac gaggttgtcg tgctccgccg ccagccggtt gcagagttcc gtcgcgatcg
      241 cggtgtcggt ccagagtgga aggtgcggac cgtgttgttc ggtggcaccc agcggaatcg
      301 ccagcagggt tcggtcggtg agttcgggcc agcggtggcc cgcgagttcg cggctcaccg
      361 cagcgagcct tcggtgaact gcggcagcag cggagcgatc gtgcgttccc gcgcgcagcc
      421 gacccaaact cctgcggagt aagccaggtc gtcgagcact cgcagggcga accacgagaa
      481 tccgccgtgc tccgcgcggc acgcctccac caagcacggc aggaacgccg cgagcagcac
      541 tgttcgggcc ttgccgctgc acagcgcagc gggcagcaac aacggccacc acgcgcgtcg
      601 cagggcctcg gcgagcagcc ttcccgcacc gaggtggccg aaagcggcca gccgcaggga
      661 ttccgcgtcg ggcacgccgc gggcgcggag cttgcgcggc agcagtgcgg cgctgaccgc
      721 tgcgaccccg agaccgatcc gcggtcgtcc ggaagcgatc agcgcccacg acgccgcgct
      781 ccacgcggac atcctggcgc agctgagttt cccgtggtgg tggcgggaca gcggtgcggc
      841 cgaggtgccg tactggtagc gctgccgcaa ccaggaccgc cagccgggtc tcgtccgatg
      901 ccgaacgacg gaaccgggct cgtagcgcac ggcaccaccg gattccagca gccgccacac
      961 caggtcgacg tcctcgccgt accgcagcga ctcgcgaaag ccgccgaggc cggccagtgc
     1021 gctgcggcgg accacgagtg ctgcgctggg cacgtagctg accctgctca tcggccggac
     1081 cagggcacgg cgtacgccca tgtccaaact ggacctgtcc gattcgtacc ggccgagcgg
     1141 agaatcctcc gccacgctcg tgatccgcgg ggcgaccgcc agcacggcgg gatcggtgaa
     1201 ctcgcgcagg acggggtcga gccacccggc gacgggttct gcgtcggcgt cgacgaacgc
     1261 gacgagttcg gtttccgcgc gtcgccagcc ggtgttgcga gcggcggcgg ggccgcgcgg
     1321 gtgttcgtgg cgaacggtgg aatcgggaac cggcgaggtg gatccgtcgt cgaccacgat
     1381 ccggttcgga atgtccgttg cggctcggag tgcgaggcgc agcccggctc gatcatcttt
     1441 gaccgggacg acgagcgtga tgtcgtcctc ggtccagatc ttgcgggcgg gctccgggtg
     1501 caccagcccg gattcgagca accgtcgcgc cagctcgctc gccgcgccgg gctcgaccgg
     1561 ctcgcccgag agccagcggt tcaccagccg ggacccggcc gcgccgagcc ggagcagccg
     1621 cagcggagaa ccgcccagca gcacgcgtcc gtcgccgagg cgccgcaacg acgggtccgg
     1681 gaccagccgc gttcctgcgg gcaggtcggt gctcatgccg tgaatccgcc gtccgcgtgc
     1741 acgactgttc cggtgatcgc ggaggagtcc ggcgagcaca ggaacgccac cacggcggcc
     1801 acttcgtcgg gttccagtat gcgctcggtg agttggtgcc cggcgaactc atccacatcg
     1861 gacaggtcgt agagccccgc gctcgcatcc agcatgtcgg tgcgggtcga accgggggag
     1921 accgcggtgg cgcacactcc ggtaccgcgc agatccgtgg ccagtccgcg caccagcccg
     1981 acgaccgcgt gcttggcagc gttgtacgag gtcaggcgcc acaatccttg atgcgcggcg
     2041 gccgaggcga gtgcgacgaa ccgtccggtc cgcggctcgg gccgccgcag cagcgcgggt
     2101 acggccgctt tcgccaagtt ggccgatccg tccacgccga ccgagaacaa cgcgtcccat
     2161 tcgcgttccc cggcctccca gaacggtcga ccgcccgcca tcaacgccgc ggcaccgacc
     2221 gccgcgtcga gtccaccgaa ccgctgctca gccagctcga ccgctcgacg cagcgcgtcc
     2281 gggtcctgca cgtcggccgc cacgtccacc acggaccctt ggaattcggc tgcaagtgcg
     2341 ctcaattgct cgggagtccc gagtggatag tccacgcgcg ggtcgtcggc gcagcgatcg
     2401 agggcgacga cccgccagcc gctgcccgcg agtctgcgca ccaccgcggc gccgatcccg
     2461 cgtgcggcgc cggtgaccag cgcgaccctc ggctcaccca tccaagtatc ctttgtctcg
     2521 caggaaagaa accagttcct cggccgcttc ggccggatcg tcggtggtca cgatccgtgg
     2581 aggttcgcgt tgttcgtgcg cgccggtgag ttcgaggact cgttgccgcg cttcgctccc
     2641 ggcaggtggc gggagctcct tggcgcgcgg acggtagccc gatgccgctc gaacccgtag
     2701 cgctgcaggt tccgctgcta cttgatgcac cgggatctcg gcggatcgag ccgccagcgt
     2761 ggcgggcagc gtcgccgtgc gcaaccggac gcccgccggt tcgaccgaac acaccgcggg
     2821 gagcggtatg gcgagccgtt cccgccgacc gcggtcgagc ctgcggacgc cccggagcct
     2881 gccgccttcg tcggtgccgg tggtctccag cgacaccagt ccgagggctt gcgcacacct
     2941 catttccgac gccagaaacg ccggtgtggc accggttccg cggtcgatcg agtggtcgcc
     3001 ggtcagcagc acgtccggaa cgccgaaccg cgcacggatg gctccggcga gcgatttcgc
     3061 cgtgcccgca ccggaatcgg cggcccgctc gtccggttcc gcgccggagt ccactcgaag
     3121 cacctcgttc gccccgcagg acaaggcttc ccgcagcaca tcctcggccg ctaccggtgc
     3181 ctgcgtcacc acgacgcacc gcccgccggt gcgttccgcg agccgcagac ccgactccag
     3241 cgcggcatga tccgccgggc tcgggccggc cattcgcggg tcggcgtgca cctcaccgga
     3301 cagcggccgc accgaggcgt gcgcgtcggt gcagcgcatc gcgaccacga tcagcactcg
     3361 cgctcacccc ttccggaacg cgacgccgta gccgccggac gggtactccc acgagatcgc
     3421 gccgctttcg tcgcacacct ggtagcaggt tccgcactcg aagcactgct cgtagttgaa
     3481 caggattccg ccgtcgtcgg tcggtacgaa caggttcgcc gggcaggcgt gcacgcaggc
     3541 gcgcgtcgtg caggagcggc acacgtcggt gtcgaccacg atgtgcggct gctcggacac
     3601 gcggaagtcc acatgcgaca tgcgttcctc gaacgagacg tcgcggtagc gttcggtcat
     3661 cgccgtcctc ccgtcagtgc tcagccgaac gaacgcaggc cggtgagcgc atccttggcc
     3721 aggtcgcgca cccgcactcc gttgcgcttc atggaccgtc gcaggagcct gcgcaggccc
     3781 ggtttcggac gcgggttgtc cactgtgaac atcccttcga cgaggtcgca gatcatgccg
     3841 ggatactgcc gttgcatccg atcggagagc accaatccgg gcgcgtcccg cagcttcttg
     3901 tggtcgccga gcacgaacga cttctccagc gacgtccgat acccggcgag cccggacgcc
     3961 gacgtatcgc cggcggccaa cgcgctcgcc gcgctgcgtc ccgcgtacat ccccgacccg
     4021 agtgcgaagt tcacgccctc caaccaaatg cccgcggcaa ggcacatccc ggccgagtcc
     4081 ccggccagca gcagtccgtc cgcggtcaac ttcggcatcg tgcgatatcc gccttcggga
     4141 atcaggtgtg cggagtactc gaccagctcg ccaccgcgga cgagcggctc gatcgacgga
     4201 tgttccttga gatcggccag gatggcctcc ggacgcatct tggccttcgc gagcccgcgc
     4261 agccccagga cgagtccgat gctcacggag tccgcgttcg tgtagaggaa accgccgccg
     4321 ggaacacctt tcgtcgcgcc cagcatctcg atgtccacac cgtccgaacc ggtgacgccg
     4381 aaccgctcgt cgatggtcgc cttcggcagc gccagcgtct ccttcacacc gagcgtcgtg
     4441 tgatcggcct ggtcgccggt gaaacaaccc gcctgcttgc ccaggaacga gttcacgccg
     4501 tcgcaggcga tcaccacccg cgcggtcaag tcgccgtccg gacgatcggt gcggatgccg
     4561 cgcacctggc cgtccggcgt gcgcagcaac gaagcggcca cagtggacgg gaccagcacg
     4621 gcgcccgctt cctgcgcgtt ctcggccagc cacgaatcga attcggcgcg gaaggtggtg
     4681 gcaccgttgt agggcgcacg gccccagttc tgggtgcgga agtcgacggt catcgagcga
     4741 tcgccgccca gcagcatggt ctgcctgcgg gtaacccagc gctgcaccgg catccggtcg
     4801 taccagccgg gcagcagttc gtcgagcacg cgcccgtaca cgacgccgcc gtagacgttc
     4861 ttggaaccgg ggaacggccc gcgctcgacc agcgccaccg agcggcccgc gcgggcgagc
     4921 tcgagcgcgg cggcggaacc ggcgggcccg gcaccgacca cgatggcgtc gaaatcgtag
     4981 tcctgcggct cggagatcgt gaccgcaccc gcggccggtc cggcaccgga ggcgttgttc
     5041 tcaggcatgg tgctcctgtc cggccgagcg gttagcgagt ctgcgcacca gttccgcgag
     5101 cagcggttgc gcgggagtga ccaggccgag atcggccatc gcggtcatcg gcgcgctggc
     5161 gtcggtgttg atcgacacgg tgtgccgcgg gtcgcggagg ccgccgatgt gttgcgccgc
     5221 accggaaacg ccgaatgcga tgtagaggtc gggatccgcg acgacgccgg tcgtgccgat
     5281 ctgccgttcg tagggcgccc aatcggcatc ggtgaccacg cgggtcgcgc cgaccgatgc
     5341 gcgcagtgcg tcagctagtt cgccgagcgc ggcgatcgcg tccgggccgg acagctcgcc
     5401 gcgcgcgagc ccggctcctg cgcccaggat tctcgatgat tcggcgaggt cggccgtcgc
     5461 gggatcgggt tcgagcacct ccaggacttc cgcgtcggca tgctgcaact cgacgtccac
     5521 tgtggttact tcgcggtccc ccgagaacgg caatgcgccg cgcacgccgg gaaccagagt
     5581 cgcaacgcag gcgggcggag tgtcgacctg cacgccgagc cgaccgtccc agcgcaccag
     5641 atcggttcct tcggcggtga accgcgtggc accggccagc agcggccggt ccagctcggc
     5701 ggcgagccgg ggtgcgaggt cgcgcccgtc cggggacgcg ggaagcagaa tccggggaac
     5761 atcggtcagc ggtgacgcca acgccttggc gaaggcgcca gcggcgaacg ggcccgcctc
     5821 ggcgcaccag ccgcggcgga tcggcagctc ggcaacggct ccggcgcagc ccgtgccgat
     5881 caaaaccgct gctccgccag cttcggcgac ggcttcatca ccgcccacgg gcggtatccc
     5941 gtcgcgcacc acgagcaccg cgaccacatc ggactcgatg cgggtcatag tcccaccgcc
     6001 actcgatgcc cctcgacgac ggcggcgtgc gcgcgccgcg gtgtgatgca gtcacctacc
     6061 cggtgcacct cgaagatgtc cgattcggac agttcgtgcc acagcgcttc ctcgggctct
     6121 tgatgcgtcg cgcacaccac ccagtcgcac ggcacctcgt cattgctgcc ggtggtgtgc
     6181 cgcaagatct gcaaccggac acctccggtg ctttcgtcgg ccgcggcgcc gaggaccact
     6241 tcatcagtgg tctgcgcgat gcccttctcc gcggcgcgtg cgttgaacgt ctccatgtcc
     6301 agggtgatcc cgaggtcctg gccgacgacc atcccggagg tcgtgatccg caccgagcag
     6361 ccccgatcgg ccagcagctc ggcgaccgag gtcgcctggt ggaacccgag gtcgtcgacc
     6421 acgatcacct ggccgtccgg ctcggcgcgg ccctccagca cgtcgcgcac gtccaccacc
     6481 cgatcgagtc caccggccca ccacggggcc tgcgggcggg cgccggtcgc cagcaccacg
     6541 acgtcgggcc gcagctcgct tatgctctgg ccggtagcgt cgacaccggt gcggacatcg
     6601 accccgcggc gatggcactc ggccagcgaa ttccgcacca catcgaggaa ttccgcccgc
     6661 tgcggcacgc tcgccgccgc cgacacctgt ccaccggtgg tttcctgccg ttccagcagc
     6721 gtcacccggt gcccgcgctg ggccgcggtc gcggcggcct gcaacccggc aggaccaccg
     6781 ccgacgatca ccacccgctt gcccgcgccg ggcatcggca gcggcacgct ctccttgccg
     6841 gtgcgcggat tctcgatgca gccgagccag cggttgagcc ccatccggcc cacgcattcc
     6901 tggttgcagg agaggcaagt ccggatgtcc gtagcgtgtc cggcgcgcgc tttcgccgcg
     6961 aagtccgcgt ccgcgatctg accgcgcacc acgccgatca gatcggagtg accttcgatc
     7021 agggcgcggt cggcctgcac ggggtccttg aacctgccga ctccgaccac cggcaggtcg
     7081 acggccttgc gcagggcgct cgggatgaac atggcgtaac cgggtgggac gctcatcgac
     7141 gcctcgatca tgtacagagt ggacgtcgcg acgccgatcg aagtgttcac gtaatccacc
     7201 gcgccggtgg actccaccat tcgcgcgact tctaccgctt cgtcgatcgt ggtgccgcct
     7261 tcgatcagct cgtccccgca cagccgcaca ccgagcgcca gatccggtcc gatggcctcg
     7321 cgcaccgctg cgaccagccg cagcagcaac cgggcgcgat tgcgcagcga acctccgtac
     7381 tcgtcctcgc ggacgttcgt ggtgggcgac aggaaccccc gcacgatcga ggaatgcgag
     7441 cactgcaact cgacaccgtc gaacccgccg gcccggcaat gtccggcgac cagcgcgtaa
     7501 cccgccacga tctcgtctat ttcggcgtgg ctgacggctt tcggcacttc ccggaacatc
     7561 gggtcgggca cggccgacgg cgcccacacc ggcagccgcg agtacatgct ggacgcctgg
     7621 ccgccgttgt ggttgagctg cgcgaagatc ggggtgccgt gcgcgtgcac cgcctcggtg
     7681 atcttgcggt agccgtccac cgcctccggg tggaacccgt ggatcagctt ctcgtagggc
     7741 caatccgtcg ggtgcgtcga atgttcttcg gtgatgatca acccggctcc gccggccgcg
     7801 cgctccgcgt agtacgccgc gtgctgatcg ctcggcaatc cgttgcgcgc gtagttggtg
     7861 aggtgcgcgg agaacacgat ccgattgcgc accgtcaccg ggccgagccg aaggggggtg
     7921 aacaggtgct tgtagcggcc ggatgcgctc atgacgcctc caccagagct cggggccgcg
     7981 cgaagctcag cgccgcacgc cgtccttcga ggatcgcctc gtgcgcggtg cgcggcgcga
     8041 cgcggtcccc ggcagtgcgg gcacgctccg gcgcgtcgct ggaaaccgga acccggtgac
     8101 cacagtggat taccgaattc gcggcgatgc tccggtgttc tccggtgaac acgtcctcga
     8161 tgtccgccgc accgccccgc acggcacgca gcaggctgcg cttggccatc gtcacccccg
     8221 cccgttgcag tcgcgcgttg gcgtcggcca gatccccggt gagcgcgagt tgcgttccga
     8281 tgacctggtc ctgactgagg atcgccgtct cgcggccggt agcggcgagc aattccgcaa
     8341 cggcgacacc ggtcgcatca ccgaccgggt cgaacacggc taccggcccg ccgggaacgg
     8401 cccgatccag gtcgccgtcc cgaaccgccc gcagcaagtc cacgacgtcg accacgaccg
     8461 cgccctcgcc gacttgataa ggccgcggtc cgggcgatga acctgttgcg agcaccaggt
     8521 tttgcgcctc catgtcggct tcctcgccga tcgtgatctg gacgtcgaga cgccggactt
     8581 caccgatgag ccagtcgacg agtttgccga tccgttcccg cgcgggcagg aatgcagcca
     8641 gcgcgagcat tccgccgagc cgttcgttcc gctcgaccag gtgcacggaa tgcccgcgca
     8701 tcgccaggac tcgcgccgcc tcgagcccgg cgggcccgcc gccggcgacg acgaccggct
     8761 caccgccgct gccgggggag acgtcggtat cggtggtctc gtgcccgctg cgcggttcgc
     8821 cgacgcagct gaccaccgga tttcggttgt cccgaacccg gcacttctgg ttggtcaacg
     8881 tgcacgggcg tacccggtca cgctgcccgg tgcgaatttt gccgaccagc cccggatccg
     8941 cgatctgcgc acgggtcatc tcgaccagat cggccgcacc ttcgtccagc gcgacttgcg
     9001 cctgctcggc ctcgacgacc gagccttgca gcacgaccgg agcggctccg gcgacggctt
     9061 cgcggatcgc cccgcacagg gcgaagttga acccaggctc ggtatgcgag tccggtgtcg
     9121 tcgccgacgc acccatcgcg gacccgcgca ccacggccag atagtcgacc tcggcagcga
     9181 gcgaggccgc gaactccttg ccctgatctt cggtgatccc ggcccacggg gcgagttcgt
     9241 cgcaggacag ccgcagtccc agcagcatcc cggaccccat ccgcgaccgg atctcgccga
     9301 ttacttcgcg caccagcagc gcacggtctt gcccgtaggc gtcaccgcgc tgattggtca
     9361 gtccggagag gaactgacgc agcagcgagt actgcccggc gttcacttcc acgccgtcca
     9421 ctccggactc tgcggccagt tcagctgcgt cgccgaatcc tccgatgagt gcgcgaatct
     9481 cccgcatctc catcgccatc ggaagctcac ggcttgccac gtcggccact ctggacggcg
     9541 cccacaacgc cgactgcgaa aacgccgaag aaccctgcga tcccgcatgt ccgagcccgg
     9601 ccagcacgag agtcccatgt ggatggcaag catcagcgac ggctgaccat ccgctcacgc
     9661 actcggtggc gagcggagcg cgctcgtaag gatggtccga ctcgtgcacc gacgcgatct
     9721 cggtgaccac gacaccggcg ccaccggaag cgcgctcggc gtaataggcc gcgtgcgcac
     9781 cggatatcgc tctgccgtcg gccaggttgg tctcgtgcgg tccgaacagc acgcggctcg
     9841 gcgcggtccg gccgcccagc ccgatcggtc cggttaggcc ggttccggcg tcgggatcgg
     9901 gcaggttcat ggtgggagcc gacttcctgg tcgcgtgacg cgtgcgccac gggtgaaaac
     9961 ggtgggaacc tgaagcgttc cgaacaggac gcgccgtccg ctacggccgg aaccccgcga
    10021 gcggactcgt gtcgcaggcc cgatccggaa tcccctcggg ttccggcggg ccccagccga
    10081 tgccgaccgg caccggcccg cccttcttct cccgcggccg ggtccggtgc gagtggtcct
    10141 tgtccggctt cggcacgccc gcgccgaccc cggccagcgc ccgttcaccg ttgcccttca
    10201 cgcactccgg atccggcccg tccaacggca acccggtgaa gaacttcgcc gccatgcacc
    10261 cgccctggca agcgtcgtag gccgagcagg aggtgcaggc gccaccggtc tgcggctccc
    10321 ggagccgctc gaagagttcg gattcccgcc acacggagcc gaatccgccg tcgtcgcgca
    10381 cgttcccggc gaggaattcc gagtggatcg cgaacgggca ggcgtagaca tcgccgatcg
    10441 ggtcgatcag gcacaccacg cgccccgccc cgcacaggtt caacccgggc agcggcgtgg
    10501 atccgagcgc gttgaggtgg aagaacgagt ccccggtgag cacgccttcg ccgtgcgcca
    10561 ccagccagtc gtagatctgg cgctgctgtt cggcggtcgg gtgcagctcg tcccacacgt
    10621 cggcgccgcg tccggacggc cgcagcctgg tgagccgcaa ctgcgcgtcg taggagtcgg
    10681 cgatctcctt gaactggtcg agctggtcga tgttctccct ggtcagcacc acactgatct
    10741 tgaatccgga gaaccccgcg gcacgcaggt tgtccatcgc ggccagcacg gtgtcgtacg
    10801 atccttcgcc gcgcacccgg tcgttgacct cagccgtcgc accgtccagg gacagctgca
    10861 cgtcgacgta gtcggtgttc gccagccacc gcgcccgctc cggcccgagc cgcacgccgt
    10921 tggtggagaa cttcacgccg acctggtggt ccactgcgta ctccaccagt tcccagaagt
    10981 ccgatcgcac ggtcggttcg ccgccaccga tgttgacgta gaagacctgc atccgctgca
    11041 gctcgtcgat gaccgctttg cattccgctg tggacagttc gcgcggatcg cggcgcccgg
    11101 aggcggaaag gcagtgcacg caggacaggt tgcacgcgta ggtcagctcc caggtcaggc
    11161 agatcgggga gtccaggccg tgctggaagt gctcgacgag tcgcatgggt ctccttgcgt
    11221 cccggctggt ggtgggagtc agtcgcgcgg tgcgatggtg cccgcgctgc acagcccggc
    11281 tagggcttcg aggtacttcg ggtgctgctc ggcgggcacc tccgccgccg cgagcgcgga
    11341 gtgcacatcg ggcttgccgt ccaattcctg aaccacggca acgagttcga gcgtcttcag
    11401 gaacgacagc ttccgggtgc tgaagtcgta gacgagcgcg ccgaaccgct ccgggcgcag
    11461 cgagacgttc gggctcagcc ggtgcggacg gccgggatcg aacccggccg ccgcgccgtg
    11521 atcagtagac gccgcacatg ccatcgatgg acacttcctc gaccagcaag tcgtcttcga
    11581 cggtctccgg tgcgggctcg tcggcctgag cttcactcat gggatgctcc tcgttcggtc
    11641 actgcgttgt gacggcgacc acgaacgata acgacaccga gtgtcaaaat ggaagaggtc
    11701 atgtccgcag cagccccgaa gcacccgtcc ggagcaaccc cgggcccggg ccggcggcgc
    11761 agcaccagcc cgcacgagct ggaacaggtc gcgttcgacc tgttcgcagg cgacggtttc
    11821 gagcacacca cggtggaccg gatcgcccag gccgcgggca tcgggcggcg caccttcttc
    11881 cgctacttcg actccaagaa cgacgtggtc tggggccggt tcaccgagca gctcgacctg
    11941 atgcgccagc ggttcagcgc ccggcccgcc gatgagccgc tgatggattc ggtgcgcgcc
    12001 gtggtcgtgg agttcaaccg ggtcgacgcc gccgagaccg agcggcaccg caggcgcctg
    12061 gagctgatct tgcgggtgcc tgcgctgcag gcccactcga cgctgcgcta tgcggaatgg
    12121 cgcgccgtgg tggcggaatt cgccgcgcag cgcctcggaa tcgccgagtc ggcgctgatt
    12181 ccgcagaccg tcgcctacgc ggcgctcggt gctgcgctgg ccgcctacga gcgatggttg
    12241 caggaacccg gcatcgatct gtgctccgtc ctcgacgacg ccttgcggca cttggccgag
    12301 ggattttccg cggtgtgacg ccggtcggca gggcgcgccg caatgtcggg ggtccggcgc
    12361 gccctgcccg cctccctcgc gcagcgcgct gcggagggga cagcggtgca gcgagcggga
    12421 ggcgccccgg aatcgtgcgg tggcgcggag ggagagtccg cacggttccg gggaagttgc
    12481 gagagcggtc tgagtgagcc tgccgtcggt tcggtcgaac cagccgctca ctcggtattc
    12541 ggggcggtca gaaatgcgcc gcgggccaac gcggatcggg ctcggccgcc ggtggatcgg
    12601 atccggtctg caatgcgtgc cgcccggtcg gctcgcccgg ctcctgcctg ttgtgcaggc
    12661 tcacccagca cgccgcgcac accagcggtg actgcgcctc gttgagggcc gcgagtcggc
    12721 ggtgcaccac tccgcggagc cgatgcccgc acagcatcgt cggcgccggg ccttgcgcgt
    12781 ccattcctgc cacgtgccac aaggattcct tcgtcgaggc catgaaatcc agcacgcgtc
    12841 cggcactgcg cacgttcctg gttctttccg catcgcccat ctccgcctcc attcgcccgc
    12901 cggccgtcag gaaagctgaa atcgctggac tgtcggtccg gtcggttatg ctcgctgtcg
    12961 gatctgctga ttgcggaaac ctagcaatgc gcgggttttc tgagaagtcg caggcaatgg
    13021 ccgcccgttc agcccttgca cgcgcaccga agccgtcgaa ggaggtcagg gtgtcgaaat
    13081 tcgcaggttc ccaggctcgg gcgatcggag ctgagatacg gcgcagtcga gattcactcg
    13141 gctggacgct ggatcgcctc gccaacgcga cggacatttc ccgttcgaca ttgtcgagaa
    13201 tcgagacggg agtccgcaga ccggaagtgg acgaggtcgc gtccgtcctg accgcgctgt
    13261 cggtcaccgg gcccgcgaag gatcggctga tccggctggc gggggatgtg tcggggacgt
    13321 gggttggcgt cggcgatgcg gtagcgcagc agctgagcgc gatctccgcc tacgaagcgg
    13381 aggcgcagtc gatctacgag ttccaggtgt cggtgatgcc cggcttgttg caaacacccg
    13441 actacacgcg cggattgatc agcaccacgc ctctcggctc ggctgagcgg gagcgggcgg
    13501 tgttcaaccg ggtcggccgc cagtcggtgc tggcgcgccc cggactgcgc tacagcgcct
    13561 tcttcgacga agcggcactg cgacgccggg tcaagtctca tgccggaacc atggtcgagc
    13621 agctacgggc cttgatcacg gtaggtgggg aggagggtcg gtctgtcagg gtcgttccgt
    13681 tctccgccgg tgcctactgg ggctgcgaga gttcgttcgt cttctacggg ctcggtggtt
    13741 gccacgtcgt ctacctcgag aaccagggga gcggagtgtt catcgacggc caatcggagg
    13801 atacttattg gaaagtactg gaaaatctgg acaacgtcgc gctggacgcg gcagagtcga
    13861 aggcactggt aactggttac ctcgaggagt acgagaatga acttcgagtt tcgtaagagc
    13921 agctacagcg ctggcggcgg cgccggcact tgcgtcgaag tggcctcgaa cgtcccggcg
    13981 gtgcgtgccg tgcgggacag caaggaaccg gagggtgctt tcctggttgt tagtcgcgac
    14041 cggttcggat ctttcttgaa gtcgctgagg ggcggccagt tcgaccgggg atagaagaga
    14101 tcgccacgcg ctcgtgtgcc ccggaggtct aacaccgggg cacacgggta ttagcggatg
    14161 accagcaaac gcacgtgaag actattcggc gacagtggaa tcgcggtcca ggttgaagac
    14221 gtcgatttga ttttgcacga acaggtcttg cagcgcgtct gagccgttcg ctgtcgcgta
    14281 ctgcctctca ccctcggaaa tcgggaccgc ctgcaaccac gccacggtct ttccgggaaa
    14341 atgcatcgtc tccagttcat cggcccagag gaatggcggg acgaacaaga tgtgccgcat
    14401 cgtggcggcg gggtagtaca tcccgacgac gtcgggaaat atcgacccgg gcgagcagaa
    14461 ccactgatcg ttgatgatga agaaggcgat ggtgctgatg atgttcggga agtgctcgtt
    14521 gtcggtggct cccgcgccga cgacctcgac ccgtaccggg tattcgttac cgtcgcgcac
    14581 cagcgggtgg tcggagagtc cgagtgtgct gcacgaggtg acgccttctg tggggctgtc
    14641 cgggcattcg aggatgtcga ccgcgctgct gtcttggtca tcccaaaagc gagtcacgct
    14701 cggtttcccg ccgaactcgg cggccgcggc acgagcgatc gctcggttgt cctcggtgac
    14761 gtcgctcatc gacactccat gctagggtcc gaagtaggaa tcggtgtggt cttcgcctcg
    14821 atgcccggag ttgtgttgag gcttctccgg gcggtagtgg tccgggttgt tgtgttcgtc
    14881 gaggaactgc ttcctagtga tgccacgttc ctcagcgctt gactgatgct tgcggaactc
    14941 gaacccaggc cgatgtccca tatgccaagg ctcttcttta gatattacct cattgctcga
    15001 tggatcacgc acttgcccgt ccggagctgc cttttccgcg tcattccaca ccgtgtctcg
    15061 gacgttcttg cggaatcctg acggccgctt gtatgtccgc gcggctttgg cgcctttgcc
    15121 ggcgagtttg ctgccggtgg cggcccagcc tccgatgggg atcatggcgg cggcggagag
    15181 gccggcgttg aggtggtcgc cttcggcggc gtaccaggcg gcgttggcgc cgtcggcgag
    15241 ttcgccgatg ccggggatga ggccgccgag gtcgagggcg gtgtggccga tgtcggccag
    15301 ggggttgctg gtgtcttcgg tgcgtcccca gggcaatcct tggtcgctac cggcagctgc
    15361 ggtgagttgg tcggccgagt agccgtactc gcccccagtg cggttcccgt cggcgttgtc
    15421 ggcggtgtag tgccggccgc cgtagaggcc ggtgatggca ttcgcgcagc ggcgttgggc
    15481 ggccatccag tccgcgaccg cttgattgac cgcggacatc aactgtgcgt cgcggtcggt
    15541 gaggtcgccg tcgtcggtcc agtccttgtc ggggacgatg ccggttttgg cggaggcggc
    15601 cagctctgag gtcgacggct tctggttctc gtaggagtgg atatcggcga cgagcgcttc
    15661 ggcctgcgcc tttaagtccc ggaggtgttg ctggaggggg cggacttcgt cggcgtagcg
    15721 ctgcaacgcg cccgcgacct gctcgacgtc gcggccgacg ttgccggcag tctcggtgac
    15781 cggccgggtg gcctgcaaca actgttcgga ctccggcgcc aggtaggcgg gcgccaagcc
    15841 ctgccaagtg gagtgcacat cggcgccggt gtcggcgaaa cccgtcccgg ccgtgcgcaa
    15901 accgttcgca tgggccgaga gcgcgtccat gttgccgggg atctgcggga tcgctcccgg
    15961 gttgatcacc gccgtcctcc cggcatgtgt gcacgcggat ccggtgccga ggcaacgccg
    16021 cgctgggcgt tgcggaccat ctcgtgatca ccctgcagat acgccccgac cgcggtcgag
    16081 gcgccgccga tggcggactg gatgcgggag aacacgaact gcatgtccgg cccacgtgcc
    16141 tcggcgaacc cggccagggc ttgcctgatg atcccggacg acgcctgccc ggccgcgccc
    16201 tccatctccg agcgcatcgc ggtcatgtgc ccgtcgaact ccgaagcggt actcgcggta
    16261 cgcgccagca caccgcgcac ctgctccggg tgaatgtccc actccacgcc tgcaaacccc
    16321 ctacgaccaa ccaaccccga caccggccga accagaagcg gtcagccgat gccttgcacc
    16381 gcggaccgcg cccgcgagat ggcgctgttg gcggagtcgt cgttctgggc catggtctgc
    16441 ttgagcaggt tgatgatctg gcggacttcg gtggccgcgg acttccagcg ttgctcgacg
    16501 tggtggtagt cgtcggagac gccgtcggcc tggaagtcgg ccatggctgc ggccacggcc
    16561 tggtcgcgtt gcgagatcac cgattccagg cgtccgatga tgccttgaat gtcgccttgg
    16621 acggattgcg agatgccggt gtcgaagctg cgccggtcca tgctcatgac gattcccccg
    16681 ggttcagcgg gcgccgaagc gggccgcgtc gaagttggcc gagccttggt tggccgaggc
    16741 gttgtcggcc atgtcggtgt cgccgtggcc gaacgagcgg tccatgccgg actgcccgcc
    16801 caagatcgcc gacagcgatc cgttgagctc gccggtgatc tcgtcggccc gtgccttgaa
    16861 cgagtcgaac gcggcccgtc cggccccgtt gaacttgcct tcgaggggtt ccgcggcggc
    16921 gatgagctgg cggatcaacg cgcccagatc atcgctggaa ccctgcgtct gcttcgtcaa
    16981 cgccgacaac gtcgacgacc ccatgtcgaa cttcatcgac gcccaccctc caacgcgaga
    17041 acaacacacc tcgcgagcac cataacgatc tggcacgaca ccgtgggccg gttgcgccga
    17101 catcgaactc ggtgccgcca ctacggcggt gcaacgtcac cgagaaagag caacgttcag
    17161 gcgggcagcg cgccgatctc gggcgaaccg ttgccgaagg tcttgtgcag gtcgcggtgc
    17221 acgacgcgat cacctgcgcg ttccaggtag cggcgtccgc gcctggtccg cccgagcagg
    17281 ccggacttga ccgagttcgc ggcgacgatg cccggcaccg cccatgccgg agtcaccggc
    17341 agctgcaggt cccgcatgtc ccgtttgccg aggaagtagc gcaacatgct cagcaaccgc
    17401 agccgcgtgt accgcccgat cactccgccg aacctgccgt ggtccacgtc gagctgcccc
    17461 tcgaccagcg cggacgacag cgcggcaccc gcgggcgtct gcccgtcctg cacgcgcagg
    17521 atgtggtagt tgaacacgtt ctgctcgcgt tcggtgtcga acagccagtc ctcgtcgaca
    17581 cccatcagcc agcccacgta cttccacagg tgcatcaccg cgcgcgactc ctcgccggtc
    17641 acgacccagc cgagtgcacg cacgccgagc agcagcgtgc tgttgaacag gccgagggtg
    17701 gatgcctggt cggtctggtt gatcggcagg ccccagcgct gcacgtccca ccggccgttg
    17761 cgctcgaagc ggtcgttgac cagggcgtgc atcgcgcgga cgtggacggt gagcttgaat
    17821 ccctcgccgt cgcggtgcat cgcgccgggc tgagtcacgg cgacggccca cttcttggtc
    17881 tcgccgagcc tgcgcagcgc ggtggagccg gtgagaccac cggtttccac cagcaggtcc
    17941 gcgggcccgc cgaaccggta gccgccgatc agcgccaact gcagcagcac gtcaccggtg
    18001 gtgcggccca tccggcgcac cgtgcgggcg ccgcgttcca gcaggtcgaa gtcgacccag
    18061 tcgggaacct gatcgacctc ggcgaagaac ttccgcagcg gttcgggcgc gtcgggcacg
    18121 ctctcgatgc cgtgctcgag cgcctggtgg aactgcgcca tccgcacgcg ctcgccgtcg
    18181 gcgcggtccc gccgcatcgc ccggaccagc tgcgcgccga gttcgtcgcg gctgtacatc
    18241 cgccggccga tccggtcgat caggtcctcg tccagcgaac gcacccgcgc gaccagccgc
    18301 agaacgcggc cgatccgcct gccgcgctcg ggtgcaccga agaaccggct cgggtacgga
    18361 ggagcgtcgt gcgctgcctg tgccaccatg cgtaggatgc tgacacgaat gatcattcgc
    18421 gttcaattcg cgttatgggg acgcggatga cggcccggcc gcgcgggcag gtgcgccgcg
    18481 aaccgagcca gcagcgctcc cgcgcgatgg tcgagcggat catcaccgcc gggcacgctg
    18541 tgctgctgga acacggctac gagcgggcca gcaccgggcg catcgcagcc gcggccggca
    18601 tcagcccggg ctcgctgtac cagtacttcc cggacaagca cgcggtgctg acgcaggtga
    18661 tcgaccgcta caccgatcgg ctgcggactc gcatttcacg cgcgttcgtg cagaacctcg
    18721 cggcgccctc cccggcggag agcgtgcgcg gcagcgtgaa cgccctgctg gacgccttcg
    18781 aggcgaacgc gggcctgatc cgggtgctct acgaacagtt gccgccgacc gcggacaccc
    18841 accgggccga gttcaagcac cgcatcgacg agctggtgac cacggcgctg ctgctgcacg
    18901 accgcgggcg cagcggcgaa ccgatcgacg cgatcgcctg ggtgctggtg cgcaccgtcg
    18961 agaacctcac gatcagctac gtgctggacc cgccgccgct cgggcgcgag accgtggtcg
    19021 acgaactcac ccggctcatc accgggtacc tcgccgaccg gatcgggcgc gcgggatgat
    19081 caaccgtccg atgtgcaact gcgcagaaag gccgaccatg ccgacgattc cggaccccga
    19141 ggccgtcgcg ggcgcgctcg cgcggctgcg cgagcggact ccgctggtgc attcgctgac
    19201 caatgtggtc tccgcgaacg tgctcaccaa cgcgttgctg gcggccggag ccaccaacgc
    19261 gatcatcgac aatccgcgcg aagccgggga attcgcgcgg atcgcggacg ccgtgctgat
    19321 caacctcgga accccggacg acgagcaggc ccgcgcgttc accgcggctg cggaatccgc
    19381 gcatgcggcc gggcatccgt gggtgctgga tcccgtgggc gtcggcggcc tgtcgtggcg
    19441 caccgaactc gccggtgggc tgctcgcgca tcggccgacg gcgatccgcg ggaatccttc
    19501 ggagatcgcg gccgtggcgg ggttggaaag cacctcccgc ggtgtcgaca gcgcttccga
    19561 tgcggccgag tcggtaccgg cggcacgaac gttgctggag gtcagcgaag tcgtttccgc
    19621 ttcggggccg atcgactaca tcaccgggcg caccgcggac gggatcgcga cggcgcgggt
    19681 gcacggcggc agcgagtggc tgccgaagat caccgccacg gggtgcgcgc tcggagcgct
    19741 cggggcggct tacctcgcgg tggcggagcc gttcaccggg atcgtggccg cacacgcgca
    19801 cttctcggtc gccgcggagt tcgctgagcc gcacgcgaac ggaccgggca cgttcgtccc
    19861 ggcgttcctc gacgcgctgg cggccgtcgg cccggacgac ctgcgcgcgc atgcgcggat
    19921 cgacagcgcc gagcactgat cgcagcgaac ggaccgttgg tcccaatgga tttggacgaa
    19981 cgggccgttc acccacgact gcgggcgggt gtgcgcaggt caccggtgta tgtgtggtca
    20041 gggcgcggga atgggaaaaa cgcgttcgac cgggtgccac cggatggcaa ccccgctcgg
    20101 cgcggcggcg tcctccggac gacgatgttc gtgagtttgg aggaaagatg cgctattccg
    20161 gtctgttgtt ggcagccgcg ctgccgctcg cggtcgccgc gcccgcgcaa gcagcggacg
    20221 ccggaaccgg gacggtctcg gggaagtact tcatggaccg caacggcgac gggcagcagc
    20281 aggcggacga accgggtccg cacgccgggt tcgtcgaact gctgacgacc gacggcaggc
    20341 aggtcgcgca cgggagtccc gacgagcagg gattctacga gttcggcgac gtcgccccgg
    20401 gtgactacca ggtccggttc aacgagggcg ggttcctgcc caccaccccg aacaacgtgc
    20461 cggtgagcgt ccaggacggt ggcaccgcgc aggccgactt cggaatgcag ggcggggaga
    20521 tctccggcat ggcgtgggag gacagcaacg gcgacgggca gcggcagcag ggcgagccgc
    20581 cgatcgccgg ggtggagatc acgagcatcg acggggcgca ataccgcgcc accaccggcg
    20641 aagacggcac ttaccgcatc gcggacgctt ggatcaacaa ggattaccgg ctgaccttcc
    20701 agccgcgcga gggcatgatg ttcgcgccgc cgcgggtcgg tgcgccggag accgactccg
    20761 atgtgatcga cgccgacgac ggcagtgccg aggcgtcggt ctgggtcggc aagcccggtt
    20821 tcatcatcaa cgcgcacaac atcgacgccg gttacgttcc gccgcgcggt tgagccgaat
    20881 tcgcgccgtt cgcggcgctg ccggggcgcg ggggacggtg gcgcgtgcgg gtgttgctcg
    20941 cccgcacgcg ccaccgcttt gatcacttgt acggctgcaa ggccgccgtg tcctcatcgg
    21001 acgccggaac gatccggatc gcgtgcccgc cgccgcgcgc gagttcggcg cgcacgacgg
    21061 tcccggcatg aaccaggaac cgatcgacgc ggaccgcgtt cgggttggtg tccaaatcgg
    21121 tctccggcgc gtccgcgtag acgtgcgcga cgaaggctcc cgcaccgagg aagtgcagcg
    21181 gaacctccag cgtccgggcc tgctcgtcgg tcagcgagcc gacgaaccag ctctgcccgc
    21241 tgcgccgcgc catggtgagg aagtcgccga tttcgccctg caccacgcgg gtttcgtccc
    21301 agctgaccgg aacttcgcgc aggaactcga actccggcgt gccctcgtag tgctccggca
    21361 cgtccgagag ctgctgaagc ccgctcagca gcaccgggta cagcgcgatc tggtgcgccc
    21421 tggtggtgtg cacgcgggtg ccgtcgttgt cgctgccgtg gtcgtcgtcc gggctctgct
    21481 ccgggaacca ggtgatgtcg aagatccccg gcgtgtagtc gaacggaccg gccagcatga
    21541 ccgt
//
