LOCUS       NZ_JADDUE010000009     21176 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Saccharopolyspora sp. HNM0986
            NODE_9_length_344811_cov_74.673391_cov_74.673391, whole genome
            shotgun sequence.
ACCESSION   NZ_JADDUE010000009
VERSION     NZ_JADDUE010000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Saccharopolyspora sp. HNM0986
  ORGANISM  Saccharopolyspora sp. HNM0986
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (bases 1 to 344811)
  AUTHORS   Li,F.
  TITLE     Diversity and distribution of actinomycetes associated with coral in
            the coast of Hainan
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 344811)
  AUTHORS   Li,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2020) chool of Life and Pharmaceutical Sciences,
            Hainan University, 58 Renmin Avenue, Meilan District, Haikou, Hainan
            570208, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 232.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016526145.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 02:15:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,899
            CDSs (total)                      :: 5,838
            Genes (coding)                    :: 5,784
            CDSs (with protein)               :: 5,784
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 7 of 54
            Pseudo Genes (incomplete)         :: 49 of 54
            Pseudo Genes (internal stop)      :: 0 of 54
            Pseudo Genes (multiple problems)  :: 2 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:09:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 155799
            Orig. end                         :: 176975
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADDUE010000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21176
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="amglyccycl"
                     /region_number="1"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /tool="antismash"
     cand_cluster    1..21176
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21176
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11176](+)"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11176
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     gene            799..2106
                     /locus_tag="INP57_RS20885"
                     /old_locus_tag="INP57_20885"
     CDS             799..2106
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673383.1"
                     /locus_tag="INP57_RS20885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20885"
                     /product="MFS transporter"
                     /protein_id="WP_200071978.1"
                     /transl_table=11
                     /translation="MDATPAIDETPRTQRRRAVVASVVGTTIEWYDFFLYSTTAALIFP
                     SVFFPHSDESTAILESFATLFVGFAARPVGAAVFGHFGDRIGRKATLISTLLLMGVATV
                     LMGLVPSHATIGLAAPVLLVVLRVLQGIGVGGEWGGSVLLSMEWGARNRRGLMASWPQM
                     GVPIGLLLSTGTVAAVSAVTGDAFEVWGWRIPFLASVVLIAVGLYIRLRVLESPDFREV
                     KQQRAVVKMPVWRALRDHPLEVLTAAFVRLSEQAPFYLFITFVLTYGTTELDMPRSQIL
                     NYTLIAAAIGLITIPLFGHLSDRFGRRRIYALGIVLTAAYAFPYFGLLNTGSGGLVLIG
                     IVVSLIVHDIQYGPQAALIAESFGTNVRYSGAGLGYQLSSVIAGGPAPLIAAALLTSTG
                     GSTSISWYIVGCCVLSLGALALMPAAGRSGTGRADG"
     gene            2275..3738
                     /locus_tag="INP57_RS20890"
                     /old_locus_tag="INP57_20890"
     CDS             2275..3738
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020629909.1"
                     /locus_tag="INP57_RS20890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20890"
                     /product="amidase"
                     /protein_id="WP_200071979.1"
                     /transl_table=11
                     /translation="MASDSVRDDELAWLDATEQAELVRGGELTPSELAEAAIERIERTN
                     GALNAVVTPLFEKAVAQAASAQLPAGPFRGVPMLLKDMVCHSAGDPLHGGMRVLRDHGW
                     TEPEDSHLAARFRAAGFVFCGKTNMPELATSVTTEPLAHGATRNPWDPSRSPGGSSGGS
                     AAAVAAGMTPVAHGNDMAGSIRVPASCCGLVGLKPTRARTSLGPGHGEYWGPVAHEHVL
                     TRSVRDSAAVLDTIRGMAPGDPYTAPPPSRPYREEIGLDPGALRVGLRTAVPGAAGQPH
                     QDCVAAVDEAARLLESLGHHVEPSAAAVLDSPAILEGFSAVFGTIVAWEVDRWSQRIGR
                     RIDLGELEPMNARTAEVGRSAPATQWLSGLHTWQQWAREAAALWEQELDVLVTPTLATP
                     PWQLGELAPTALAPAELAAAVGEKIAFTVPFNITGQPAISLPLHRNPDGLPIGVQFVAA
                     YGREDVLIRLAAQLEQAAPWSMARPPVSA"
     gene            complement(3772..4653)
                     /locus_tag="INP57_RS20895"
                     /old_locus_tag="INP57_20895"
     CDS             complement(3772..4653)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024092.5"
                     /locus_tag="INP57_RS20895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20895"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_200071980.1"
                     /sec_met_domain="PF07366 (E-value: 1.1e-07, bitscore: 25.9,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDHDNSANRSIAEAAVAAFAAGWRAPHPHAWDDLLAEEAELVQPL
                     LRHRVGRHALAEEYGRLLELIPDLRGEVLRWAAEGRTVRIELRLTGTLGRLPLRLAVTD
                     QLTLDEDGRILRRQARLDPLPAVALLARQPAAWRRWWNSGVGPLLVRRKFLPHDLEHVP
                     TPPLVRALAFGRLLLAVSAWVAPQRSARLVGLAADGPRENYLMRVFAGRAAALGLGTLT
                     SRGRRQRQWQLLGLLVDLSDTAAAFSRGMSIRARVLGLLTGGYAVAGISALRSEPEDDS
                     AQEAAPGPDEVR"
     gene            complement(4820..5884)
                     /locus_tag="INP57_RS20900"
                     /old_locus_tag="INP57_20900"
     CDS             complement(4820..5884)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016338104.1"
                     /locus_tag="INP57_RS20900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20900"
                     /product="PDR/VanB family oxidoreductase"
                     /protein_id="WP_200071981.1"
                     /transl_table=11
                     /translation="MFTPPPDVHGRGRPDRFMRGLAALMSVYSKLIAFDRPRPPVRAVD
                     RDLRLVVDDARAEADDVRSLRLVPADGSALPAWSPGAHIDVVLPSGRQRQYSLCGDPAD
                     RGCYRIAVRRIADGGGGSREVHAELDVGSRITARGPRNAFPFIRAQRYLFVAGGIGITP
                     ILPMVRAAAAAGSDWRFVYCGRSRESMPFLDEIARLAPERVWVRPDTEYGVPVSSGELL
                     EHAPEDATVYCCGPVPMITGVRMDLAISRAAELHWERFSAPPIVDGKPFDLHLERTGRT
                     LHVPEDRTALEVVREALPDVAYSCRQGFCGTCKVGLLSGTAEHRDHVLTDDERADSMTI
                     CVSRAEQGPLVLDL"
     gene            complement(5893..6864)
                     /locus_tag="INP57_RS20905"
                     /old_locus_tag="INP57_20905"
     CDS             complement(5893..6864)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020632374.1"
                     /locus_tag="INP57_RS20905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20905"
                     /product="metal-dependent hydrolase"
                     /protein_id="WP_200071982.1"
                     /transl_table=11
                     /translation="MTHDEHPPKSGVDDPERVALQARNVRFDWSELPMHWIPDEPFATH
                     VINVLHLLLPEGEDWFVEVFKQALPMIKDDRLREDVQGFVGQEAVHAMSHQGVLDHFNA
                     HDLDTEPYVRQIAWMFRKLLGDRGHTGARAEDWVVERVGLIAGIEHITAFLGQWVLDAE
                     ALDRAQADPTMLDLLRWHGAEEVEHRSVAFDLFMHLDGRYSKRVRFFLLALPLFFTLWA
                     RGAKFLIANDPKLRGRLKPRWRDYFRSARLGLLPGPRQTARLMAPYFRPSFHPSQHGST
                     TRAVSYLARSPAAQAAENPAAPASERPAAPASDHPAAPASDH"
     misc_feature    complement(7923..7933)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            8002..8505
                     /locus_tag="INP57_RS20910"
                     /old_locus_tag="INP57_20910"
     CDS             8002..8505
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017885.5"
                     /locus_tag="INP57_RS20910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20910"
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="WP_200071983.1"
                     /transl_table=11
                     /translation="MLSCRRSRRWAAELVDELALPARFSTEFLLGRVAARKGRRLEVLP
                     LPVSGGVGRPHGLWVQAAEADYIFVEPRTSALHRRHIVLHEIGHILAHERVARGRGREE
                     FRSLVPDLDPEVVQRLLARAHDGTADAAEREAEEIATALGRRIRDAPPRRVPAVGGVLG
                     FRAS"
     gene            8505..9680
                     /locus_tag="INP57_RS20915"
                     /old_locus_tag="INP57_20915"
     CDS             8505..9680
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042915.1"
                     /locus_tag="INP57_RS20915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20915"
                     /product="MAB_1171c family putative transporter"
                     /protein_id="WP_200071984.1"
                     /transl_table=11
                     /translation="MIDQLPVPAGQALELGGIAALWLALLVRVPDALRRRDMRSFWATC
                     SGIAAAMALHTDLSCALLRELSGDPQVVHVLRNSVAVAASCLVLHNFTAYLRFPLRKSL
                     PIGFGAVVASALLFTDLRAVGFWSRPVAEGVLGSYWSGFLPLHFAADLTAGLLCVRAVR
                     SGGPPPFRLGMSAYAAGFLLGAGVGIPLAGVGAAVGDPGLREFGPVVSGLQACCLAIGV
                     GAPLLSAVCADLRKRRGLHAIYPLWMDMIRAVPEVNRTEVRSRIRALLRSPSAVGTLRY
                     RLIIEIRDAVLVLSHYCSPELAAAARAHAAERASRTGRPEAVVLACWLRRAVLERAGGG
                     PACGAGSALPGGDDLDEEERFLLEVAEVYRSGPALRFALGRAPQAVVAPGR"
     misc_feature    complement(9719..9733)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.62"
                     /tool="antismash"
     gene            10001..11176
                     /locus_tag="INP57_RS20920"
                     /old_locus_tag="INP57_20920"
     CDS             10001..11176
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102640.1"
                     /locus_tag="INP57_RS20920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20920"
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_200071985.1"
                     /sec_met_domain="salQ (E-value: 2.7e-153, bitscore: 504.4,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Fe-ADH (E-value: 5.7e-12, bitscore: 39.3,
                     seeds: 218, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 4.2e-69, bitscore:
                     226.8, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPESTGSGRTSTTWRVGARQPVDYEVVIARGLLEPQNRELAQACG
                     ADGVATRCLVLIDDAVDVLYGEALRAYFDAWSIDTSWTVINGSEESKSIAQVVAATEAM
                     SSMGILRRAEKVIAIGGGAVLDVAGMAASLYRRGVPYVRVPTTLIGQVDAGVGVKTGVN
                     YGTHKNRLGSYYAPEKALIDPEFLRTVPQRHINNGMAEIAKMALIKDRELFELLESVAG
                     EVSAATLADAGPHLLEIMTRAIGGMLDELEPNLWEHELERVVDYGHTFSPSLELRADPP
                     LLHGEAVAVDMAVCVAVAHNRGLLGHEGADRALALLQALGLPTTDPVFTTELLAESLQD
                     AVRHRDGAQRVPLTSGLGSAVFVNDIDDGELAAALEFVRAAAGTGLVRASR"
     gene            11173..12195
                     /locus_tag="INP57_RS20925"
                     /old_locus_tag="INP57_20925"
     CDS             11173..12195
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012692.5"
                     /locus_tag="INP57_RS20925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20925"
                     /product="ROK family protein"
                     /protein_id="WP_200071986.1"
                     /transl_table=11
                     /translation="MNPVAVVDVGGTRLRSATWTPRGGLRDRTEAASPGRYRDPDATPE
                     QLRARLVQEICQAVPARPDAVAGVSVGAALDHRTGAVYASAPLWGDCTEPLDLLGELRA
                     ARPDVRWHVVNDVTAALLHAAASPVLAAVRKVLLATISTGIACRVIDQRDGRIAVDDCG
                     LQGEIGHLPAHAAMRGEPLRLRCDCGAPSHLAAFSSGPGIRRVAELLRLNRPRQWQESL
                     LGKRIADGAAFEDAFAAALHSADAAATELLSVVTEPVADVVRTALCLDPELDRIVLTGG
                     VAVGLDEHYRTAVLEHLDRAGTYLTGELAPDWARRRIEIAGPESADCLVGAGIAAAGQR
                     "
     gene            12192..13265
                     /locus_tag="INP57_RS20930"
                     /old_locus_tag="INP57_20930"
     CDS             12192..13265
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019845.5"
                     /locus_tag="INP57_RS20930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20930"
                     /product="alcohol dehydrogenase catalytic domain-containing
                     protein"
                     /protein_id="WP_200071987.1"
                     /sec_met_domain="ADH_N (E-value: 2.9e-09, bitscore: 31.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGRHRALVRGSGRIAVELRPTPRPAAGELLVATKFAGLCGTDIQ
                     MLRGLRDDAAEVIGHEGIATVISAGAGAGPGPGTEVVVNPTHPSSESFLLGHNVNGLLQ
                     ERTLVPRDAVEAGLVLPLETAPEPELAALLEPLSVVRYALSALQRFRPETLVVFGGGTV
                     GRLAIRAAHRWLGPAVRTVLVHRGAEPGLTGAHTDIRTDDLGAVRGLVAVLVATPRDGT
                     VECLRAALGMSADSLVVDLVGGLSAGAEVPELPGVDLAAVRAANRTGFPDPPSTYTGRA
                     PNGGHVRLFGHRGVSAEHLRAAAAELVRDPGRYRDVITHVTGLGGAARIMRDLARGGDR
                     IVDGRRLVKLAVRVGDP"
     gene            13287..14036
                     /locus_tag="INP57_RS20935"
                     /old_locus_tag="INP57_20935"
     CDS             13287..14036
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (10-171). E-value: 9.6e-10.
                     Score: 30.6. Matches aSDomain:
                     nrpspksdomains_INP57_RS20935_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012334.5"
                     /locus_tag="INP57_RS20935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20935"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_200071988.1"
                     /transl_table=11
                     /translation="MTQISEPARALVVGGSTGIGRAIAGAWAETGAEVIVASRSRPDDA
                     ALGWLQIDLSDPAGTRRALAEVVRQGPLHAACYSAVHYGDKRAPLRDVAESEWLHQLEV
                     NLNGLWRTVAAVSAALREAAPGLFVGVSSEVVYNAGPGRPGYAATKSAAASLLDSLAQE
                     ESAEALRVVQVLPSGMVDTPGIRRRRPADFDYGEYMRPACFAPLAAELLRTRGTEQHGD
                     HLVVQPDGSWRSVHAGLPESQSREPAT"
     CDS_motif       13317..13406
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_INP57_RS20935_0001"
                     /evalue="2.80E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="INP57_RS20935"
                     /protein_end="40"
                     /protein_start="10"
                     /score="13.6"
                     /tool="antismash"
                     /translation="LVVGGSTGIGRAIAGAWAETGAEVIVASRS"
     aSDomain        13317..13799
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_INP57_RS20935_PKS_KR.1"
                     /evalue="9.60E-10"
                     /label="INP57_RS20935_PKS_KR.1"
                     /locus_tag="INP57_RS20935"
                     /protein_end="171"
                     /protein_start="10"
                     /score="30.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LVVGGSTGIGRAIAGAWAETGAEVIVASRSRPDDAALGWLQIDLS
                     DPAGTRRALAEVVRQGPLHAACYSAVHYGDKRAPLRDVAESEWLHQLEVNLNGLWRTVA
                     AVSAALREAAPGLFVGVSSEVVYNAGPGRPGYAATKSAAASLLDSLAQEESAEALRV"
     gene            14033..14812
                     /locus_tag="INP57_RS20940"
                     /old_locus_tag="INP57_20940"
     CDS             14033..14812
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013429.5"
                     /locus_tag="INP57_RS20940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20940"
                     /product="TIM barrel protein"
                     /protein_id="WP_200071989.1"
                     /transl_table=11
                     /translation="MSPPLVGVVDWRLPVRGGAAVELAGRIGADGVQLDLGGPGRGERL
                     DGPGRLGRIREASCRAGVAVLAVAVNAMNDIGLMSGDAAVRSTLLRALDAAGALGAGLV
                     FVPSFRRSAIDGTAALRSTAEVLRWAAAEAAARGLLLASENVLDSRQARAMATAVGSDS
                     FRLLLDTYNLVAAGGDPVRLVSAVPELLADQIHVKDGPGGDASRVLAAVARSGTDVGAL
                     VLENDHRDDDAARLRRDLARLRRYAARFTDAPNSEEF"
     gene            14812..15471
                     /locus_tag="INP57_RS20945"
                     /old_locus_tag="INP57_20945"
     CDS             14812..15471
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013675063.1"
                     /locus_tag="INP57_RS20945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20945"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_200071990.1"
                     /sec_met_domain="HAD_2 (E-value: 4.1e-22, bitscore: 73.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQRVITARILLFDMDGTLVDSSAVVERTWRLFAERHGLDGATVL
                     ADAHGRPTAETVARHLPGATDAAAETARIVASEVSDVDGIVPVPGAVELLSQLPAANWA
                     VVTSAGRELAERRMAAAGLNLPGVVVSADDVRSGKPDPEGYLLAAERLGATAAEAVVFE
                     DAAAGLLAARSSGASPVVVGGHDGPAAVGLPRVEDLRSVTTDRRTHDGLLVQIRNR"
     gene            15485..16669
                     /locus_tag="INP57_RS20950"
                     /old_locus_tag="INP57_20950"
     CDS             15485..16669
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013884.5"
                     /locus_tag="INP57_RS20950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20950"
                     /product="acyltransferase"
                     /protein_id="WP_200071991.1"
                     /transl_table=11
                     /translation="MNANWGITERDRKSRLPSLTGMRFLSALLVFFFHASCTTPPWTFF
                     GDPAQAGAFSAITADAGRIGVAFFFVLSGFVLTWSGDVVGSVTDFWRRRLVKIVPNHLV
                     TWVLAMLLFSGSTVAAGTALANLLLVHPWMPDYYTFLSVNVPSWSLGCELLFYLSFPAL
                     LPLIRRIPDRWLWASATGVIAAVFGVAVVAQFLLPAEPALPEANSPGSVWQFWLVYFLP
                     ATRVLDFALGIVMARIVLRGRWIGLGLGPAALLTAVSYVLASFVPWVFHLNAATIIPLA
                     LLIPAAACADIRGRRSPLRGRFAVWLGEISFAFYMVHALVLTGTRALLGENTYFGAGGA
                     GLVVLAELVVSVLGAWLLYTAVERPVMRRFGRRRAVRSTVDSAAPAAAPTTTAK"
     gene            16678..17742
                     /locus_tag="INP57_RS20955"
                     /old_locus_tag="INP57_20955"
     CDS             16678..17742
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019845.5"
                     /locus_tag="INP57_RS20955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20955"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_200071992.1"
                     /sec_met_domain="ADH_N (E-value: 1.9e-23, bitscore: 76.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.9e-15, bitscore:
                     51.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTAADAAADRTPRAEMSALVLEAPGTISEQRMVTPAPRPGHYLV
                     EIGLLGLCGTDLGFYDGSSNYLADGLKSFPFVFGHEWSGRVVGIGAGGTRFALGQRVSG
                     HNFRPCGRCASCSRGTPRYCPQRSEIGVLGAEPGAAADYLEVPEDSLIGLPDPVGDAAA
                     VLLEPGSAAVHAVRRLEITGEDRVAVLGAGTLGLVAAQVCAGLGARVAVFDPQPGPREL
                     AAELGIAEVGAPQQAAPDAYSAVIEASGAVAAVRGAPELCAPGGRIAQLGTPHHAIDGF
                     PAATLVVKNVTLHAVLSGIGYWADMLEFVEKRLLRLEPLVDSIHSRSEVGAAFGQLAAS
                     GRRRPKILLRMNAR"
     misc_feature    complement(17745..17759)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.91"
                     /tool="antismash"
     gene            17769..18554
                     /locus_tag="INP57_RS20960"
                     /old_locus_tag="INP57_20960"
     CDS             17769..18554
                     /NRPS_PKS="Domain: Abhydrolase_1 (23-246). E-value:
                     1.5e-20. Score: 65.8. Matches aSDomain:
                     nrpspksdomains_INP57_RS20960_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012770.5"
                     /locus_tag="INP57_RS20960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20960"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_200071993.1"
                     /sec_met_domain="Thioesterase (E-value: 2e-11, bitscore:
                     38.7, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.8e-19, bitscore:
                     64.8, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 2.4e-17, bitscore: 57.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTVSTSTAKVYYTASGSGPGLALVHGTGADSASNFGHLVERFAD
                     RRTVITPDYAGSGATEDDGRPITVEALTEQVAAVLRDAADEPVDLAGFSLGAVVAASVA
                     ARHPELVRRLVLIAGWQDSSDPRHRLAFDLWRRLADLDARAYAQMINLLLFTPGFLSRM
                     GADALEEAVAGTACSDGTNRQIDLGLAADITGLTPKITAPTLVIGCTHDQLVPVEHSRQ
                     LHESIPGSRYLELDSGHLVVAERPDELVAAVRDFLHDEN"
     aSDomain        17838..18506
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_INP57_RS20960_Abhydrolase_1.1"
                     /evalue="1.50E-20"
                     /label="INP57_RS20960_Abhydrolase_1.1"
                     /locus_tag="INP57_RS20960"
                     /protein_end="246"
                     /protein_start="23"
                     /score="65.8"
                     /tool="antismash"
                     /translation="LVHGTGADSASNFGHLVERFADRRTVITPDYAGSGATEDDGRPIT
                     VEALTEQVAAVLRDAADEPVDLAGFSLGAVVAASVAARHPELVRRLVLIAGWQDSSDPR
                     HRLAFDLWRRLADLDARAYAQMINLLLFTPGFLSRMGADALEEAVAGTACSDGTNRQID
                     LGLAADITGLTPKITAPTLVIGCTHDQLVPVEHSRQLHESIPGSRYLELDSGHLVVAER
                     P"
     CDS_motif       18024..18086
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_INP57_RS20960_0001"
                     /evalue="5.50E-05"
                     /label="NRPS-te1"
                     /locus_tag="INP57_RS20960"
                     /protein_end="106"
                     /protein_start="85"
                     /score="15.7"
                     /tool="antismash"
                     /translation="EPVDLAGFSLGAVVAASVAAR"
     gene            18585..19775
                     /locus_tag="INP57_RS20965"
                     /old_locus_tag="INP57_20965"
     CDS             18585..19775
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="INP57_RS20965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20965"
                     /product="MFS transporter"
                     /protein_id="WP_200071994.1"
                     /transl_table=11
                     /translation="MPIPVFALMLGVFCVGTAEVAISGLLPNVAADLVVTVPSAGLLVT
                     GYALGVTVIGPAVTLLTSRVRRKPLVLGLMAVFVAGNLVAVVAPNYGLLMAARVFTATS
                     HGTFVALAFYLAVLIAPPGRKGSAMAKISLGFNLANALGSPLGTFVGQRFGWRSTFAVI
                     AVVAIVTVVLIAVFLHPPADRAQPAGRSNLRAEVRELGSPALGMAVVITVLAQGAVFTT
                     STYLVPILQDVSGFAPGLMSALLVVFGVGSVCGNFAGGRIADGHVLRGVLLLLSTLTAV
                     CALFWVVAPVPALAVGAVLLFGAAGFSIIPSLQTHIETIAAAAPTLALSVNVSAFNLGN
                     GLGAWLGGQVIDLGMGTRSVLLTSAVVCGASLALTAGSYLLGHGAQKRTAVPATAG"
     gene            19791..20639
                     /locus_tag="INP57_RS20970"
                     /old_locus_tag="INP57_20970"
     CDS             19791..20639
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670667.1"
                     /locus_tag="INP57_RS20970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_20970"
                     /product="TIGR03619 family F420-dependent LLM class
                     oxidoreductase"
                     /protein_id="WP_200071995.1"
                     /transl_table=11
                     /translation="MQLHLILPAETPDMPFTELRELAVLAERLGYRGAWLPDHLLPPGR
                     YEPGSYGGVFDPLVALAAIAGATSEIRLGTSVLVLPLRSPFVVAKQAATIERISAGRFT
                     LGVGIGWDAAEFSTVGAEFTGRAARADEAIELIRQLLGGDGAFTGRHCGSPGGVFEPVP
                     TGPVPIAVGGSGKPALRRAARLGDEWQPIRPCPERFAADLAWLRANSARPVRASVRTSW
                     TGGAAELDQVLAEVSGYERAGAAATAIWFGSDAGVPERMAEFIPAANEVLRNSAGRWPR
                     T"
     gene            complement(20581..21054)
                     /locus_tag="INP57_RS20975"
                     /old_locus_tag="INP57_20975"
     CDS             complement(20581..21054)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS20975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_20975"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_200071996.1"
                     /transl_table=11
                     /translation="MNRAADPAEQLPKTLADKLGYLIDIHVRQADQRGDGSGRWPTFEK
                     LAAEISEATGKSISHGYLHQLCRGHRDNPTLHHLQGLAEFFRVPVAFFTDDESTREIIA
                     QYELVLAMRSSRIREICTYAPLLDGEGLDEVTALVKSLAIGRQSSAEPRSPQG"
ORIGIN
        1 acgcccgcac tcggctgccg cacgacccga aaggcgacgg cgagcaccgc ggattggtgc
       61 acacaccggt cttcgcggtc gccaccggac tgctcgtcgg gctcggcgcg ctggtcacgc
      121 cgtgggtgac gatggcgacg ctgatcgtcg tgctcgcgcc cggcatcgcg gcgctgtccc
      181 gctccggtcc cggatgggtg cgccgccggt tgcgcacgca tcgggacggg atggcgctgc
      241 tggccgccgc ggtgatcacg ctcgcgctgc tcgtcggcgg ggaaggggac gaactcggct
      301 ggtacgccgg ggtttccatc gcggtcggca tgatcgtgca ctccgcgggc gattccgcca
      361 cccgcagcgg aatcccgtgg acgtggccga tgcgccgccg atgctcgcag tgctcgggac
      421 cggcggagtg cgcgggcagc cgctggcggc gcgggcacgt gctgccgaag aacctgcggt
      481 ggcgggtggg ttcccggtcc ggccagcgca tcgagcaggt catcgaggtg atctgcctgg
      541 tgctggtggc ggcgctggtg ctcccggacc tgagcaccct gctgaccggt tgagcgatct
      601 gctccgccgc gaccggagcg aactcgaccg gcccggtggc tgcagcggat cacggctttg
      661 aactgctcgt agccggtgtg caccgagcgc ggaagcagcg ccgcgcgctc ctcgcgtcct
      721 gaaccgggga tttcgtacgt tgacaaagca accgggcgga gcaatcctca gtggccattc
      781 cgggcaggga ggccgcacat ggacgcaacg ccggccatcg acgagacacc gcgcacccaa
      841 cgccgccgag ccgtcgtcgc cagcgtcgtc ggcacgacca tcgagtggta tgacttcttc
      901 ctctacagca ccaccgcagc gctgatcttc cccagcgtgt tcttcccgca ctcggacgag
      961 agcacggcca tcctcgaatc gttcgccacg ctgttcgtcg gcttcgccgc ccggccggtc
     1021 ggtgcggcgg tgttcgggca cttcggcgac cgcatcggcc gcaaggccac gctgatcagc
     1081 acattgctgc tgatgggcgt ggcgacggtg ctgatgggcc tggtcccgag ccacgcgacc
     1141 atcgggctcg ccgcaccggt gctgctggtc gtgctccggg tgctgcaggg catcggagtc
     1201 ggcggcgaat ggggcggttc ggtgctgctg tcgatggaat ggggcgcgcg gaaccgccgc
     1261 gggctgatgg cgagctggcc gcagatgggt gtgccgatcg ggctgctgct gtccaccggc
     1321 accgtcgccg cggtcagcgc ggtcaccggg gacgcattcg aggtctgggg ctggcggatt
     1381 ccgttcctgg ccagcgtggt gctcatcgcg gtcggcctct acatccggct gcgcgtgctg
     1441 gagagcccgg acttccgcga ggtcaagcag cagcgcgcgg tggtgaagat gccggtgtgg
     1501 cgggcgctgc gggaccaccc gctggaggtg ctcacggccg cattcgtccg gctgtccgag
     1561 caggcgccgt tctacctgtt catcacgttc gtgctgacct acggcacgac cgagctggac
     1621 atgccgcgca gccagatcct caactacacg ctgatcgcgg cggccatcgg cctgatcacc
     1681 atcccgctgt tcgggcactt gtccgaccgg ttcgggcgca ggcgcatcta cgctctgggg
     1741 atcgtgctca cggctgcgta cgcgttcccg tacttcgggc tgctgaacac cggcagcggc
     1801 gggctggtgc tgatcggcat cgtcgtgtcg ctgatcgtgc acgacatcca gtacgggccg
     1861 caggcggcgt tgatcgcgga aagcttcggc accaacgtgc gctacagcgg agcgggcctg
     1921 ggttaccagc tctcgtcggt catcgcgggc ggtccggcgc cgctgatcgc cgcggcgctg
     1981 ttgaccagca ccggaggcag cacgagcatc agctggtaca tcgtcgggtg ctgcgtgctg
     2041 tcgctgggcg cgctggcgct gatgcccgcg gccggtcgaa gcgggacggg ccgagcggac
     2101 ggctgagcgc cgcccggcgc gctgaccgcc cgcgagcggc tgcggggccg gtgatcggca
     2161 gggcaggtgg gtccatccgt tgtcctggca gggttgcgcc gattcgtgag ccggtgcagg
     2221 caactgtgcg aaggtgatcg cgaccggcat cggatctcgg gggcaaggat ggacatggct
     2281 agtgactcgg tgcgcgacga cgaactggcg tggctggacg cgacggagca agccgagctg
     2341 gtgcgcgggg gcgagctcac accctcggaa ctcgccgagg cggccatcga acgcatcgag
     2401 cgaaccaacg gcgcgctgaa cgcggtcgtc acgccgctgt tcgagaaagc ggtggcacag
     2461 gccgcatcgg cgcagttgcc cgcaggcccg ttccgcgggg tgccgatgct gttgaaggac
     2521 atggtgtgcc actccgctgg cgacccgttg cacggtggga tgcgggtgct gcgcgaccac
     2581 ggctggaccg agccggagga ttcgcacctg gcggcgcgat tccgcgcggc agggttcgtg
     2641 ttctgcggca agaccaacat gcccgagctg gccaccagcg tcaccaccga accgctcgcg
     2701 cacggcgcga cgcgcaaccc gtgggacccg tcgcgttcgc ccggtggctc cagcggcggc
     2761 tcggccgccg cggtcgccgc cgggatgacg ccggtcgcgc acggcaacga catggcgggt
     2821 tcgatccggg ttcccgcgag ctgctgcggg ttggtggggc tcaagcccac gcgggcgcgc
     2881 acctcgctag gtccgggcca cggtgaatat tggggaccgg tggcccacga gcacgtgctg
     2941 acccgttcgg tgcgggacag cgccgcggtg ctcgacacga tccgcggcat ggcgcccggc
     3001 gatccgtaca ccgcgccgcc gccttcccgg ccataccggg aagaaatcgg cctcgaccca
     3061 ggggcgctgc gtgtcgggct gcgcaccgcg gtgccgggag cggccggtca gccgcaccag
     3121 gattgcgtcg cagcggtgga tgaagccgcg cgactgctgg agtcgctcgg gcaccacgtc
     3181 gagccgtccg cggcagcggt gctggactcg cccgcgatac tcgagggttt ttccgccgtg
     3241 ttcgggacca tcgtcgcttg ggaggtcgac cgctggtcgc agcgcatcgg caggcggatc
     3301 gacctcggtg agctggaacc gatgaacgcg cggactgccg aagtgggccg ctcggcgccc
     3361 gccacgcagt ggctctccgg tttgcacacc tggcagcaat gggcgcgaga ggcggccgcg
     3421 ctgtgggagc aggagctgga cgtgctggtc acgccgacgc tggcgacgcc gccgtggcag
     3481 ctcggtgaac tcgcgccgac cgcgctggca ccggccgagc tcgctgccgc ggtaggcgag
     3541 aagatcgcgt tcaccgtgcc gttcaacatc accggacaac cggcgatttc gctgccgctg
     3601 caccggaatc ccgatggctt gccgatcggg gtgcagttcg tcgccgcgta cgggcgcgag
     3661 gacgtgctga tccggctcgc cgcccagctg gagcaggccg cgccgtggtc gatggcgcgg
     3721 ccgccggtgt cggcgtgagc ggggtaccgg cggattgcgc ttgggcgtgc gctaccgaac
     3781 ctcgtccggg ccgggagcgg cttcctgcgc cgagtcgtcc tccggctccg agcgcagcgc
     3841 gctgatcccg gcaacggcgt aaccgcccgt cagcaggccg agcacccggg ccctgatcga
     3901 cattccgcgg gagaaggccg cggcggtgtc ggaaagatcc accagcagcc cgagcagctg
     3961 ccactggcgt tgccggcgcc cgcggctggt gagcgtgcca agcccgaggg ccgcggcgcg
     4021 tccggcgaac acccgcatca ggtagttctc ccgcgggccg tctgctgcca ggccgaccag
     4081 ccgggcggag cgctgcggcg ccacccaggc cgaaaccgcc aacagcagcc gcccgaacgc
     4141 gagcgcgcgc acgagcggcg gggtgggcac gtgttcgagg tcgtgcggca agaacttccg
     4201 ccgcaccagc aacggcccga ccccggagtt ccaccagcgc cgccacgccg cgggctgccg
     4261 ggcgagcagc gccaccgcgg gcagcggatc gagccgggcc tgcctgcgca ggatgcggcc
     4321 gtcctcgtcg agggtgagct gatcggtgac cgccagccgc agcggcaacc ggccgagcgt
     4381 tccggtcagc cgcagctcga tccgcacggt gcggccttcg gccgcccagc gcagcacctc
     4441 acctctcaga tccgggatga gctcgagcag ccgcccgtac tcctcggcca gcgcgtgcct
     4501 gcccacccgg tgccgcagca gcggctggac cagctccgct tcttcggcga gcaggtcgtc
     4561 ccaggcgtgc gggtgcggag ctcgccaccc ggcggcgaac gccgccacgg cagcctcggc
     4621 gatcgatcgg ttcgcggagt tgtcgtggtc cacgtcgtct cctcgcgggt ggcgcggact
     4681 caggtcgtgg gtgagcccgg gcggtgatga agcccttcgg cggtgtagta gagcatgtcg
     4741 gcggcagatt gcggaacgtc gtgcgcgcag tccggcagcg agtctgcgcc ggttccaaca
     4801 ggtcgttgcg gaggctccgt cagaggtcga gcaccagcgg gccctgttcg gcgcgggaaa
     4861 cgcagatcgt catggaatcg gcccgctcat cgtcggtgag cacgtggtcg cggtgctcgg
     4921 cggtgccgct gagcaggccc accttgcagg tgccgcagaa gccttgcctg caggagtagg
     4981 cgacatcggg gagcgcttct cgcaccacct ccagcgccgt ccggtcttcg gggacgtgca
     5041 gcgtgcggcc ggtgcgctcg agatgcaggt cgaacggttt cccgtcgacg atcggcggcg
     5101 ccgagaaccg ttcccagtgc agctcggcag cccggctgat ggccaggtcc atccgcacac
     5161 cggtgatcat cggtaccggg ccgcagcagt acaccgtggc gtcctccggt gcgtgctcca
     5221 gcaattcacc gctggagacc gggactccgt actcggtgtc cgggcggacc cacacccgtt
     5281 ccggggccag ccgggcgatc tcgtccaaga acggcatcga ctcccgcgac cgtccacaat
     5341 agacgaaccg ccaatcgctg cccgcggcag ctgcggcacg caccatcggc aggatcgggg
     5401 tgatgccgat gccgccggcc acgaacaggt agcgctgcgc ccggatgaac gggaaggcgt
     5461 tgcgcggtcc ccgcgcggtg atgcggctcc cgacgtccag ctccgcatgc acttcgcgcg
     5521 aacccccgcc gccgtcggcg atccggcgaa ccgcgatccg gtagcagccg cgatccgccg
     5581 gatcgccgca caacgagtac tggcgctgac gacccgacgg cagcaccacg tcgatgtgcg
     5641 ctcccggcga ccacgcgggc agcgcggatc catccgcagg taccagccgc aggctgcgca
     5701 cgtcgtccgc ttcggcgcgc gcgtcgtcga cgaccaaccg caggtcgcgg tccaccgccc
     5761 gcaccggcgg tcgcggccgg tcgaaggcga tcagcttgct gtagaccgac atcagcgcgg
     5821 cgaggccgcg catgaaccgg tccggccggc cccgtccgtg cacgtccggt ggtggcgtga
     5881 acatcgcggc gctcagtggt cggaggccgg tgcggcgggg tggtcggagg ccggtgcggc
     5941 cgggcgctcg gaggccggtg cggccgggtt ctccgcggcc tgcgcggccg gtgacctggc
     6001 caggtaggac accgccctgg tcgtcgagcc gtgctgcgac gggtggaacg aaggccggaa
     6061 gtacggtgcc atcaaccggg cggtctgccg cggtccgggc agcaggccca gccgggcgct
     6121 gcggaagtag tcccgccagc gcggcttcaa ccgcccgcgc agcttcggat cgttcgcgat
     6181 caggaacttc gccccgcgcg cccacagcgt gaagaacagc ggcagtgcga gcaggaagaa
     6241 ccgcacccgc ttggaatacc ggccgtccag gtgcatgaac aggtcgaacg cgaccgagcg
     6301 gtgctcgacc tcctccgcgc cgtgccagcg cagcaggtcc agcatggtcg ggtcggcctg
     6361 cgcgcggtcg agcgcttccg cgtcgagcac ccattggccg aggaacgcgg tgatgtgctc
     6421 gatgcccgcg atgaggccga cccgttccac cacccaatcc tcggcgcgcg cgccggtgtg
     6481 gccgcggtcg ccgaggagtt tgcggaacat ccaggcgatc tggcgcacgt atggctcggt
     6541 gtccaggtcg tgggcgttga agtggtccag cacgccttgg tgcgacatgg cgtgcacggc
     6601 ctcctggccg acgaacccct gcacgtcctc gcgcagccgg tcgtccttga tcatcggcag
     6661 cgcctgcttg aagacctcga cgaaccagtc ctcgccctcg ggtagcagca ggtgcagcac
     6721 gttgatcacg tgggtggcga acggctcgtc cgggatccag tgcatcggca gctcggacca
     6781 gtcgaaccgc acgttccgcg cctgcagcgc aacgcgctcc ggatcgtcca caccggactt
     6841 cggtgggtgc tcgtcgtgcg tcatcgcaag acctcctcgc ggtgcggctc ggcggggcgt
     6901 tgctcgctcg accggttcgc gggccggatc cggcgagcgg ccgccacctg ttactggaag
     6961 taacgggtac tggaggtggc actatgcagc gctgcgcgcg ccgctgtcaa cgcgcgctcg
     7021 gcccgatgca tcgtgcgccg ggtgcggggc gatcgaggcg cagctcggcg cacggatgcg
     7081 tgggccggcc gtgagcggtg cgtcgccttc ctcagcgggt cggatctccg gtcggcaggt
     7141 gccgtgctcg ctgcgcgtcc cgccaccggg gaccggccgt tttcggccgt ccggcggcac
     7201 cgaacgcacg ccccgcgaac ccgcggaatc tcggtcggtg cgcgccgggc caaggcctga
     7261 ccgctcgtag acgggcaaga tcacccccga gccagcgggt gcgcgcgaag gaggaaccga
     7321 gtcgggaact cgtacggatt cggtcgccgg gtcacggtgt cctcccgttc gcccggacgg
     7381 acatctccgt gcggcgaaag ctttcgggaa tggttcttcc ggtgtcgtcg atcgacacca
     7441 cttggcgtcc gaagtgctat gcggcccgga tcgaccgtcg cgcgcgagga gatcgtccac
     7501 tgcccggcga atcctgggat catcgtcacc cgggccgccg aactcctcgg catgagccgg
     7561 gcgacgatcg ccgcaaggtg tcgcggtacg gcaccccggg ctgagcagcc gccgcagcgc
     7621 ccggctcgcg cgcagcgacg acgcagaagg cgcggccgga acgggcgccg aaagcggccg
     7681 gtgcttcgct gccgacagga gcacgctcga accgggaagc gcaatcagga tgaactgatt
     7741 gtgaattgtg cctcgcgcat cgtgcgacgt ttgatcatgt ttccggttcc gggcaggttt
     7801 ctcgctggaa ttcggggcct gctccggggt cggtgcggca ggatccgcag gcgggtgatc
     7861 ttgatttccc ggccgggtcg gtgcgctgcg tttccgccgc gatgcggcgt tgatccctgt
     7921 gagtgagatt gcattgaccg gtgtccgcga tgttcgtgaa gatggtactg atctaggggc
     7981 atttactggg ggagtgttcc gatgttgagc tgccgacgtt ctcgtcgatg ggccgccgaa
     8041 ctcgtcgacg agctggcatt gcccgcgcgc ttttcgacgg agttcttgct ggggagggtc
     8101 gctgcgcgca aggggcgccg gctggaggtg ttgccgcttc cggtttcggg aggggtcggc
     8161 cgaccgcacg ggttgtgggt gcaagccgcg gaggccgact acatcttcgt ggagccgcgg
     8221 acgagcgcgc tgcaccggcg gcacatcgtg ctgcacgaga tcggccacat cctggcgcac
     8281 gagcgagtgg cgcggggccg ggggcgggag gaattccgca gtctggtgcc cgacttggac
     8341 ccggaggtgg tgcagcggct gctggctcgc gcgcacgacg gcaccgccga tgccgcggag
     8401 cgggaggccg aggagatcgc gaccgcgttg ggacggcgca tccgggacgc gccgccgaga
     8461 agggtcccgg cggtcggggg agtgctgggc ttccgggcgt cgtgatgatc gaccagctgc
     8521 cggtcccggc cgggcaggca ctggaactcg gcggcatcgc ggcgctgtgg ctggctctgc
     8581 tcgtgcgggt accggatgcg ttgcggcggc gtgacatgcg gtcgttctgg gcgacgtgca
     8641 gcgggatcgc ggcggccatg gcgctgcaca ccgatctgtc atgcgcgctg ttgagggagt
     8701 tgtcgggcga cccgcaggtg gtgcacgtcc tgcgcaactc cgtcgcggtg gccgcgtcgt
     8761 gcctggtgct gcacaacttc accgcatatc tgcggtttcc gctgcggaag tcgttgccga
     8821 tcgggttcgg tgcggtggtg gccagcgcgc tgctgttcac cgatctgcgc gcggtcgggt
     8881 tctggagccg tccggtcgcc gaaggggtgc tgggcagcta ctggtccgga ttcctgccgc
     8941 tgcacttcgc cgcggacctc acggcgggcc tgctgtgcgt gcgggcggtt cgcagcggcg
     9001 ggccaccacc gttccggctc ggaatgtcgg cgtacgccgc gggtttcctg ctgggtgccg
     9061 gggtcgggat tccgctggcg ggagtcggcg cggcggtggg ggatccggga ttgcgggagt
     9121 tcggcccggt ggtgtcgggg ttgcaggcgt gctgcttggc gatcggagtg ggcgctccgc
     9181 tgctgtccgc cgtgtgcgcg gatctgcgga agcggcgggg cctgcacgcc atctatccat
     9241 tgtggatgga catgatccgt gccgtccccg aggtgaaccg caccgaggtg cggagcagga
     9301 ttcgagcgct gctgcgctcg ccgtcggccg tcggaacgct ccggtatcgg ctgatcatcg
     9361 agatccgcga tgcggtgctg gtgctgagcc actactgctc gcccgagctc gccgccgcgg
     9421 cgcgagcgca cgccgcagaa cgcgcgtccc ggaccggtcg gcccgaagcc gtggtgctgg
     9481 cctgctggtt gcggcgcgct gtcctggaac gcgccggtgg cggccccgcc tgcggcgcgg
     9541 ggtccgcgtt gcccggtggg gacgatctcg acgaggagga gcggttcctg ctcgaagtcg
     9601 cagaggtgta ccgatccgga cccgcgctgc ggttcgccct cggccgggcg ccgcaagcgg
     9661 ttgtcgcacc cggccgctga ggcggtccgg ccgatggcgg gtttcgggca ggtgacgcga
     9721 atttcaaaat catccatttc agttgacggt tgatatcggg gtgactagtc tcgatcgcag
     9781 cgacgcaagc tgacatggat gtcgtcactg gggagttcga caccgccgga cggtcggcgg
     9841 ttcgtcccgc tcgtcgtcgc gcaccggcac tgcggccggt cccgttcatg gtcgggagtc
     9901 cctccgatcg gatgcggtgt gcctggggtg agccgcagcg ccgcgtccga ccgggtcgcc
     9961 accggccgcg gtcgaacaat tgctttcctg gggaggaaaa atgccggaat ccaccggatc
    10021 cgggcggacc agcacgacct ggcgcgtcgg cgcccggcag cccgtcgact acgaagtcgt
    10081 gatcgcgagg ggactgctgg agccgcagaa ccgggaactg gcgcaggcgt gcggggcgga
    10141 cggcgttgcg acgcggtgcc tggtgctcat cgacgacgcc gtggacgtgc tctacggcga
    10201 ggcgctgcgc gcgtacttcg acgcctggtc gatcgacacg agctggaccg tgatcaacgg
    10261 ttcggaggaa tccaagagca tcgcgcaggt cgtggccgcg accgaggcga tgagctcgat
    10321 gggcatcctg cgccgggccg agaaggtcat cgccatcggc ggcggtgccg tgctggacgt
    10381 ggccggcatg gccgccagcc tctaccgccg aggagtgccg tacgtgcggg tgccgaccac
    10441 cctcatcggc caggtcgacg ccggagtggg ggtcaagacc ggcgtcaact acgggacgca
    10501 caagaatcgg ctgggcagct actacgcccc ggagaaggcg ctgatcgacc cggagttcct
    10561 gcgcacggtc ccgcagcggc acatcaacaa cggcatggcc gagatcgcca agatggcgct
    10621 gatcaaggac cgcgagctgt tcgagctgct ggagtcggtg gccggcgaag tcagcgcggc
    10681 cacgctggcc gacgccggcc cgcacctgct ggagatcatg acccgcgcca tcggggggat
    10741 gctcgacgag ctcgaaccca acctgtggga gcacgagctg gagcgggtgg tggactacgg
    10801 gcacacgttc agcccgtcgt tggaattgcg cgcggacccg ccgctgctgc acggcgaggc
    10861 ggtcgcggtg gacatggcgg tgtgcgtggc cgtggcgcac aaccgagggc tgctcggcca
    10921 cgagggcgcg gaccgggcgc tcgccctgct gcaggcgctg ggattgccga ccaccgaccc
    10981 ggtgttcacc accgagctgc tcgccgagtc gttgcaggac gcggtccggc accgggacgg
    11041 tgcgcagcgg gtaccgctga ccagcgggct cggttccgcg gtgttcgtca acgacatcga
    11101 cgacggcgaa ttggccgcgg cgctggaatt cgtgcgcgcg gcggcgggca ccggcctggt
    11161 gcgggcgagc cgatgaaccc ggtcgcggtg gtcgacgtcg gcggtacccg gctgcgcagc
    11221 gccacctgga caccgcgggg cgggctgcgg gaccggaccg aagcggcctc gcccgggcgc
    11281 taccgggacc ccgatgcgac gccggagcag ctgcgggcac gcctggtgca ggagatctgc
    11341 caggccgtcc cggccaggcc ggatgcggtg gccggagtct ccgtcggcgc ggccctggac
    11401 caccggaccg gtgcggttta cgcctcggcg ccgctctggg gggactgcac cgagccgttg
    11461 gacctcctcg gtgaactgcg cgcggcgcgg ccggatgtgc gatggcacgt ggtcaacgac
    11521 gtgaccgcgg ccctgctgca cgccgcggcc tcgccggtac tcgcagcggt ccggaaggtg
    11581 ctgctggcca cgatcagcac cggcatcgcg tgccgcgtga tcgaccaacg ggacggccgg
    11641 atcgcggtcg acgattgcgg cctgcaaggc gagatcgggc acctcccggc gcacgccgcg
    11701 atgcgcggag agccgctgcg gctgcggtgc gattgcggtg cgccttcgca cctcgccgct
    11761 ttcagctcag gccccggcat ccgacgggtg gccgagctgt tgcggctgaa ccggccccgt
    11821 cagtggcagg aatcgctgct ggggaagcgg atcgcggacg gcgcggcgtt cgaggacgcg
    11881 ttcgccgcgg cgctgcacag cgccgatgcg gcggcgaccg agctgctgtc ggtggtcacc
    11941 gaaccggtgg ctgacgtggt gcgtacggcg ctgtgcctgg acccggaact cgatcgaatc
    12001 gtcctcaccg gcggggtcgc agtcggcttg gacgagcact accgcacggc tgtgctggag
    12061 cacctggacc gggcgggcac ctacctgacc ggtgaactgg cgccggactg ggcgcggcgg
    12121 cgcatcgaga tcgccggccc ggaatcggcc gactgcttgg tcggcgcggg catcgccgcg
    12181 gcggggcagc ggtgagcggg cggcaccgcg ccctcgtgcg cggttccggc aggatcgcgg
    12241 tggaactccg gccgacgccg cgccctgccg caggggagct gctggtcgcc accaagttcg
    12301 ccgggttgtg cggcacggac atccagatgc tccggggact gcgcgacgac gccgccgagg
    12361 tgatcggaca cgaagggatc gcgaccgtga tctccgccgg cgccggtgcg gggccggggc
    12421 cgggcaccga agtcgtggtg aacccgaccc acccgtcctc cgagtccttc ctgttggggc
    12481 acaacgtgaa cggcctgctg caagagcgca ctctggtgcc gcgcgacgcg gtcgaagctg
    12541 gcctcgtgct cccgctggaa acggccccgg agccggaact ggcggcattg ctcgaacccc
    12601 tctcggtggt gcggtacgcg ctgagcgcgt tgcagcggtt ccgcccggag acgttggtcg
    12661 tcttcggtgg cggaaccgtg ggccggttgg cgatccgcgc cgcgcaccgc tggctcggcc
    12721 cggccgtgcg caccgtgctc gtgcaccgcg gtgccgaacc ggggctcacc ggagcgcaca
    12781 ccgacatccg aaccgatgat ctcggcgcag tgcgcggatt ggtggccgtt ctggtggcga
    12841 cgccgcgcga cggcacggtc gagtgcctcc gcgccgcgct gggcatgtcc gcggacagcc
    12901 tggtggtgga cctggtcggc gggctgtccg ccggtgcgga agtgccggag ctgcccgggg
    12961 tcgacctggc cgcggtcagg gccgcgaacc gcaccgggtt ccccgatccg ccgagcacgt
    13021 acaccggacg agccccgaac ggcgggcacg tgcggttgtt cgggcatcgc ggggtttccg
    13081 cggagcacct acgcgcggcc gcagccgaac tcgtccggga ccccgggcga tatcgggacg
    13141 tcatcacgca cgtgaccgga ctcggcggcg cagcacgaat catgcgcgat ctcgcccgcg
    13201 gcggagatcg catcgtcgac ggcagacgcc tggtgaagct cgccgttcgc gtcggcgacc
    13261 cgtagcaacg acacgaggag cacttgatga cgcagatttc cgagccggcg cgcgcgttgg
    13321 tcgtcggggg ctcgaccggc atcggacgcg cgatcgccgg cgcctgggcg gaaaccggcg
    13381 cggaagtgat cgtggccagc cgcagccgtc cggacgatgc ggcgctcggc tggctgcaga
    13441 tcgacctgtc cgatccggcg ggcaccaggc gggcgctggc cgaggtggtc cggcaaggac
    13501 cgctgcacgc ggcctgctac tccgccgtcc actacgggga caagcgagca ccgttgcgcg
    13561 acgtggccga atccgagtgg ctgcaccagc tcgaagtgaa cctcaacggg ctgtggcgca
    13621 ccgtggccgc cgtgtcggcg gccctgcgcg aggccgctcc cgggctgttc gtgggggtgt
    13681 cgtcggaggt ggtctacaac gcgggcccgg gcagacccgg ttacgcggcc accaagtcgg
    13741 ccgcggcgag cttgctggac tcgctcgcgc aggaggagag cgccgaggcg ctccgggtcg
    13801 tgcaggtact gccctccggc atggtcgaca ctcccgggat ccgccgtcgg cggcccgcgg
    13861 acttcgacta cggcgaatac atgcggcccg cctgcttcgc gccgctcgcg gcggagctgc
    13921 tgcgcacccg cggcaccgag cagcacggtg accacttggt ggtgcaaccg gacggttcat
    13981 ggcgctccgt gcacgcgggt ctgcccgaat cgcagagcag ggagccggcc acgtgagccc
    14041 gccgctggtc ggcgtcgtcg attggcgact gccggtgcgc gggggagccg cggtcgagct
    14101 ggccgggcgg atcggcgcgg acggcgtcca gctcgatctc ggagggccgg ggcgtggcga
    14161 gcggctcgac ggtcccgggc ggctcggccg catccgggaa gcgtcctgcc gggccggggt
    14221 cgcggtgctc gcagtggccg tgaacgccat gaacgacatc ggcctgatgt cgggcgatgc
    14281 cgctgtgcgc agcacgctgc tgcgtgcgct cgatgcggcg ggcgcgctcg gcgccggcct
    14341 cgtgttcgtg ccgagtttcc gacgcagcgc catcgacgga accgcggcgc tgcgcagtac
    14401 cgccgaagtg ctgcggtggg cagcggccga agccgccgcg cgcggcctgc tgctggcgag
    14461 cgagaacgtg ctcgactccc ggcaagcgcg ggcgatggca acagcggtcg gctcggattc
    14521 cttccgcctg ctgctggaca cctacaacct ggtcgcggcc gggggcgacc cggtgcggct
    14581 cgtctcggcc gttccggagc tgctcgccga ccagatccac gtgaaggacg gcccgggcgg
    14641 agatgcgtcg cgggtgctcg cggccgttgc gcgatccggg accgatgtgg gcgccctcgt
    14701 gctggagaac gaccaccggg acgacgacgc ggcgcggctt cggcgcgatc tggcccggtt
    14761 gcgccggtac gccgcccgat tcaccgatgc accgaacagc gaggaattct gatggaccag
    14821 cgagtcatca ccgcccggat cctgctgttc gacatggacg gcacgctcgt cgactcgtcc
    14881 gcggtcgtcg agcggacctg gcgccttttc gccgaacgcc acggcctcga cggtgcgacg
    14941 gtgctcgccg atgcgcacgg ccggccgacc gcggagacgg tcgcccggca cctgccgggc
    15001 gccaccgacg cggccgcgga gaccgcccgg atagtggctt ccgaggtgtc cgatgtggac
    15061 ggaatcgtgc cggttcccgg cgcggtggag ctgttgtcgc aactgccggc cgcgaactgg
    15121 gcggtcgtga cctcggcagg ccgggaactg gccgaacggc gcatggccgc ggccgggctg
    15181 aacctgcccg gcgtcgtggt gagcgccgac gacgtccgat cggggaaacc cgatccggag
    15241 ggctacctgc tcgccgccga acggctggga gcgaccgccg cggaggcggt cgtgttcgaa
    15301 gacgccgccg ccggattgct ggccgcgcgc tccagcggag cgagcccggt cgtggtcggg
    15361 ggccacgacg ggccggccgc ggtcggcctt ccgcgggtcg aagacctgcg ttcggtcacc
    15421 accgaccggc gaacccacga cggactgctc gtgcagatcc ggaacagata ggagtagatc
    15481 tgctgtgaac gcaaactggg ggatcaccga acgggaccgg aagtcccgat tgccgtcgct
    15541 gacgggtatg cgtttcctgt cggcgctgct cgtgttcttc ttccacgcct cctgcacgac
    15601 gccgccgtgg accttcttcg gcgacccggc gcaagcaggc gcattcagcg cgatcaccgc
    15661 tgacgcgggc cgcatcggag tcgccttctt cttcgtgctg agcggtttcg tgctgacctg
    15721 gtccggcgac gtcgtgggca gcgtcacgga tttctggcgc cgccgactcg tgaagatcgt
    15781 gcccaaccac ctggtcacct gggtgctggc gatgctgctg ttcagcggca gcaccgtcgc
    15841 ggcggggacg gcgctggcga acctgctgct ggtgcacccg tggatgcccg actactacac
    15901 cttcctgagc gtcaacgtgc cgagctggtc gctggggtgc gagctgctgt tctacctgtc
    15961 cttcccggcc ctgctcccgc tgatccgcag gattccggac cgctggttgt gggcttcggc
    16021 gacgggcgtg atcgcggccg tgttcggcgt cgcggtcgtg gcgcagttcc tgctgcccgc
    16081 ggagcccgcg ctgccggagg cgaactcccc cgggtcggtc tggcagttct ggttggtgta
    16141 cttcctgccc gccacccgcg tgctcgactt cgcgctgggc atcgtcatgg cgcgcatcgt
    16201 gctgcgcggg cggtggatcg ggctcgggct cggtccggca gcgctgctga ccgccgtgag
    16261 ctacgtgctc gcctcgttcg tgccgtgggt gttccacctc aacgccgcca cgatcattcc
    16321 gctggcgctg ctgatcccgg ccgcggcctg cgccgacatc cgggggcggc gatcgccgtt
    16381 gcgcgggcgt ttcgcggtgt ggctgggcga gatctcgttc gccttctaca tggtgcacgc
    16441 gctggtgctg accggaacgc gggcgctgct gggcgagaac acctacttcg gagccggggg
    16501 tgcggggctg gtcgtgctcg cggaactcgt cgtctcggtg ctcggggcgt ggttgctcta
    16561 caccgccgtg gaacgaccgg tcatgcgcag gttcggccgc cgccgcgcgg ttcgctccac
    16621 tgtggactcc gctgcgcccg cggccgcacc gaccaccacc gcgaaatgag gtcttccatg
    16681 cagactgccg ccgacgccgc cgcggaccgg acgccgcggg cggagatgtc cgcactggtg
    16741 ctggaagctc ccgggacgat ctccgaacag cggatggtca cgccggctcc tcgcccgggg
    16801 cactacctgg tcgagatcgg ccttctgggg ctgtgcggaa ccgacctcgg cttctacgac
    16861 ggttccagca actacctcgc cgacgggctg aaatcgttcc cgttcgtctt cgggcacgag
    16921 tggagcggcc gggtcgtcgg catcggtgcc ggcggcacgc ggttcgcgct cggacagcgc
    16981 gtttccgggc acaatttccg gccctgcggc aggtgcgcct cctgctcccg gggaactccc
    17041 cggtactgcc cgcagcgcag tgagatcggg gtgctcggtg cggagccggg cgcggcagcc
    17101 gactacctgg aagtcccgga ggattccttg atcgggcttc ccgacccggt cggcgacgct
    17161 gccgcggtgc tgctggaacc cggttcggcc gcggtgcacg cggtccggcg gctggagatc
    17221 accggcgagg accgggtggc ggtcttgggc gcgggcacgc tcgggctcgt ggccgcgcaa
    17281 gtgtgcgcgg ggctgggagc ccgggtcgcg gtgttcgacc cccagcccgg accgcgggaa
    17341 ctcgccgcgg agctgggcat cgcggaggtg ggggctccgc agcaggccgc gcccgacgcc
    17401 tactccgccg tgatcgaggc atccggcgcg gtcgcagccg tccgcggcgc gccggaactg
    17461 tgcgcgcccg gcgggcgcat cgcccagctc ggcactccgc accacgcgat cgacggattt
    17521 ccggccgcca ccttggtggt gaagaacgtg acgctgcatg ccgtcttgtc cggaatcggg
    17581 tactgggcgg acatgctgga attcgtggaa aaacggctgc tgcggctgga accgttggta
    17641 gattcgatcc attcgcgatc cgaagtcggc gcagccttcg gtcagctcgc cgccagcggc
    17701 cgccgacgtc cgaagatcct gctgcgcatg aacgcgcggt gaaatccgca aaaggagcaa
    17761 tgaaacctgt gagcactgtt tccacgtcga cggcgaaggt gtactacacg gcttccggca
    17821 gcggccccgg attggcgctg gtgcacggaa ccggggcaga ttccgcgtcg aacttcgggc
    17881 acctcgtcga gcgcttcgcc gaccggcgaa ccgtgatcac cccggactac gcgggcagcg
    17941 gcgcgaccga ggacgacgga cggccgatca ccgtggaggc gctgaccgaa caggtcgccg
    18001 cggtgctgcg cgacgccgcc gacgagccgg tggacctggc cgggttctcg ttgggcgccg
    18061 tggtcgcggc atcggtcgct gcgcggcatc cggagctggt gcggcggctg gtgctcatcg
    18121 cgggctggca ggactcctcc gatccgcggc accggctggc gttcgacctg tggcggcggc
    18181 tggccgatct ggacgcgcgg gcgtacgcgc agatgatcaa cctgctgctg ttcacgccgg
    18241 ggttcttgag ccggatgggt gccgacgcgc tggaggaggc ggtggcggga acggcgtgct
    18301 cggacgggac gaaccggcag atcgacctcg ggctcgccgc ggacatcacc ggcctgacgc
    18361 cgaagatcac cgcgccgacg ctggtcatcg gctgcaccca cgaccagctc gtgccggtcg
    18421 agcactcccg gcagctgcac gaatcgatcc cgggcagccg ctacctggaa ctcgacagcg
    18481 ggcacctcgt ggtcgccgaa cgccccgacg aactcgtcgc cgccgttcgc gacttcctgc
    18541 acgacgagaa ctgacggacc aggacggaga cgaggttccg ccccatgccc attcccgtgt
    18601 tcgctctcat gctcggcgtg ttctgcgtcg gcaccgccga agtggcgatc tccggactgc
    18661 tcccgaacgt cgcggccgac ctggtggtga ccgtgccgtc agcgggcctg ctggtcaccg
    18721 gctacgccct cggcgtcacg gtgatcggcc cggcggtcac cctgctgacg agcagggtgc
    18781 ggcgcaaacc gctggtgctc ggtttgatgg ccgtgttcgt ggcgggcaac ctcgtcgccg
    18841 tcgtcgcccc gaactacggg ctgctgatgg cggcccgggt attcaccgcc accagccacg
    18901 gcacgttcgt cgccctcgcc ttctacctcg cggtgctcat cgcgccgccg gggcggaagg
    18961 gctcggcgat ggcgaagatc tcgctcgggt tcaacctggc gaacgcgctc ggttcgccgc
    19021 tgggcacctt cgtcggccag cggttcggct ggcgatccac gttcgcggtc atcgcggtgg
    19081 tggcgatcgt gacggtggtg ctgatcgcgg tgttcctgca cccgcccgcc gaccgcgcgc
    19141 agcctgccgg gcggtcgaac ctgcgcgcgg aggtccgcga actgggcagt ccggcgctcg
    19201 ggatggccgt ggtgatcacc gtgctcgcgc agggcgcggt gttcaccacc tcgacctacc
    19261 tggtcccgat cctgcaggac gtcagcgggt tcgcacccgg gctgatgtcg gcgctgctgg
    19321 tggtgttcgg ggtgggatcg gtctgcggga acttcgcggg cggtcgcatc gcggacgggc
    19381 acgtgctccg gggcgtgctg ctgctgctga gcacgctgac cgcggtgtgc gcgctgttct
    19441 gggtggtcgc gccggtgccc gccctggccg tgggcgcggt gctgctgttc ggagcggcgg
    19501 ggttctccat catcccgagt ctgcaaacgc acatcgagac gatcgcggcc gccgcaccca
    19561 ccctcgcgct gtcggtgaac gtctcggcgt tcaacctcgg caacggcctc ggagcgtggc
    19621 tcggcggcca ggtcatcgac ctcgggatgg gaacccggtc ggtgctgctg acctccgcgg
    19681 tcgtgtgcgg cgcgagcctg gccctgaccg cgggttcgta cctgctcgga cacggcgcgc
    19741 agaagcggac ggccgtgccc gcgacggccg gctgacagga ggaactcccg gtgcagctgc
    19801 acctgatcct tccggcggaa acaccggaca tgccgttcac cgaactccgc gaactggccg
    19861 tgctggccga acggctcggc taccgcggtg cgtggttgcc ggaccacctg ctgcctcccg
    19921 ggcggtacga accgggcagc tacggaggcg ttttcgaccc gctcgtcgcg ctggcggcca
    19981 tcgccggtgc gaccagcgag atccggctcg gcacgtcggt gctggtgctg ccgttgcgga
    20041 gcccgttcgt cgtggccaag caggccgcga cgatcgagcg gatctccgcg ggccgtttca
    20101 cgctcggcgt cggaatcggc tgggacgcag cggaattcag cacggtcggg gcggagttca
    20161 ccggtcgagc ggcgcgtgcg gacgaggcca tcgagctgat ccggcagctg ctcggcggtg
    20221 acggcgcgtt caccggtcgg cactgcggtt cgcccggcgg cgtcttcgaa cccgtgccga
    20281 ccgggccggt gccgatcgcg gtgggcggtt ccgggaagcc ggcgctgcgg cgggccgcgc
    20341 ggctcggcga cgagtggcag ccgatccgcc cgtgcccgga acggttcgcc gcggacctcg
    20401 cctggttgcg cgcgaactcg gcgcgcccgg ttcgcgcgtc ggtgcgcacg tcgtggaccg
    20461 gaggggccgc ggagttggat caggtgctcg cggaggtgag cggttacgag cgggcgggag
    20521 ccgccgcgac ggcgatctgg ttcggctcgg atgccggcgt gccggagcgg atggccgagt
    20581 tcatccctgc ggcgaacgag gttctgcgga actctgccgg ccgatggcca aggacttgac
    20641 cagcgcggtg acctcgtcca gcccttcccc gtcgagcagc ggggcgtagg tgcagatctc
    20701 gcggatccgg ctgctgcgca tcgccagcac gagctcgtac tgcgcgatga tctcacgggt
    20761 gctctcgtcg tcggtgaaga acgccaccgg cacgcggaag aactcggcca gcccctgcag
    20821 gtggtgcagc gtcgggttgt cgcggtgacc gcggcacagc tggtgcaggt agccgtgcga
    20881 gatcgacttg ccggtagcct cgctgatctc cgcggccagc ttctcgaagg tcggccaccg
    20941 cccggagccg tccccgcgct ggtcggcttg ccgcacgtgg atgtcgatca ggtacccgag
    21001 cttgtccgcc agcgtcttcg gcagctgctc ggcggggtcg gcggcccggt tcatgagtac
    21061 ctccacccga acgaactacc tccactgcca gattagctga cctcgcggcc atcggggacc
    21121 gcccgcgggc gcgggagcca aaaccgcagg cagcgcggat gtgccgcgtg gcatcc
//
