LOCUS       NZ_JADDUE010000004     11242 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Saccharopolyspora sp. HNM0986
            NODE_4_length_512363_cov_75.780038_cov_75.780038, whole genome
            shotgun sequence.
ACCESSION   NZ_JADDUE010000004
VERSION     NZ_JADDUE010000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Saccharopolyspora sp. HNM0986
  ORGANISM  Saccharopolyspora sp. HNM0986
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (bases 1 to 512363)
  AUTHORS   Li,F.
  TITLE     Diversity and distribution of actinomycetes associated with coral in
            the coast of Hainan
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 512363)
  AUTHORS   Li,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2020) chool of Life and Pharmaceutical Sciences,
            Hainan University, 58 Renmin Avenue, Meilan District, Haikou, Hainan
            570208, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 232.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016526145.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 02:15:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,899
            CDSs (total)                      :: 5,838
            Genes (coding)                    :: 5,784
            CDSs (with protein)               :: 5,784
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 7 of 54
            Pseudo Genes (incomplete)         :: 49 of 54
            Pseudo Genes (internal stop)      :: 0 of 54
            Pseudo Genes (multiple problems)  :: 2 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:09:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 412976
            Orig. end                         :: 424218
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADDUE010000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11242
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11242
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11242
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6242](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6242
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            1431..2057
                     /locus_tag="INP57_RS12275"
                     /old_locus_tag="INP57_12275"
     CDS             1431..2057
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224723.1"
                     /locus_tag="INP57_RS12275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_12275"
                     /product="SRPBCC family protein"
                     /protein_id="WP_200070262.1"
                     /transl_table=11
                     /translation="MPEVEQQINAVTRTVGTRELEAGTANVVTIAQSCPAPVADVWDAC
                     TNAERIPRWFMPISGDLSEGGRYQLEGNAGGTVQRCDPPNGFDATWEFGGATSWIEVRL
                     TAEDASSTRMELRHIELDNDNWAEYGPGAVGVGWDMGLLGLAVHFTGDSAYGAEWIGSA
                     EGSRFAWLSSKAWCAANIAAGTPEAQATACADRTTAAYTAPPEGS"
     gene            complement(2080..2925)
                     /locus_tag="INP57_RS12280"
                     /old_locus_tag="INP57_12280"
     CDS             complement(2080..2925)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009944366.1"
                     /locus_tag="INP57_RS12280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_12280"
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="WP_200070263.1"
                     /transl_table=11
                     /translation="MTHRWAPDSPCGPGCLPRPGSVRRAGTHRVALRLAGAAGLMLAGI
                     GVAVVFALLWRSARTALVRSWFRALLRVLGIRFAVRGEHRLDSGALVVTNHVSWLDVVA
                     LMAVRPMRLLAKTEVRSWPVIGPLAGRVGTLYIDRERLSALPGAVRTIADSLRGGAVVG
                     AFPEGTTWCGLASGRYRPAVFQAAVDARVPVQPVALRFSAGGRPTTAAAFVGEATLLES
                     VLAVARVRDLVVELSLLPEMDAAAVGDRRELARRTERAVAEVTAPAEPHLPHLPQPAAA
                     "
     gene            complement(2922..3701)
                     /locus_tag="INP57_RS12285"
                     /old_locus_tag="INP57_12285"
     CDS             complement(2922..3701)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009944365.1"
                     /locus_tag="INP57_RS12285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_12285"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_200070264.1"
                     /transl_table=11
                     /translation="MSESTLLASTAPAGSPTTATTPYSLLVARDSDEVRAAQRLRYEVF
                     AEEMGATVHGDAPGVETDPFDEHCDHLIVRDDRTGEVVGTYRMLPPERAREAGGLYSET
                     EFDLSALGELRPALVETGRSCVHRDHRTGGVVSLVWAGIARYMLLHGHTWLAGCASVPL
                     DDGGALAAKVWDTVSAKHYAPEDSRVQPYLPWNPEPVERTHRGPLPPLLKGYLRLGAQV
                     CGRPAHDPEFGVADFFVLLDFTRIDPRYLRFFLGAAA"
     misc_feature    3763..3777
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.5"
                     /tool="antismash"
     gene            4022..4489
                     /gene="rnhA"
                     /locus_tag="INP57_RS12290"
                     /old_locus_tag="INP57_12290"
     CDS             4022..4489
                     /EC_number="3.1.26.4"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="rnhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010305515.1"
                     /locus_tag="INP57_RS12290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_12290"
                     /product="ribonuclease HI"
                     /protein_id="WP_200070265.1"
                     /transl_table=11
                     /translation="MPQQDEAGARDRVELFTDGACSGNPGPGGWGVVLRYGTHERELHG
                     GEPGTTNNKMELTAVIEGLAALTRPMPVVLVHTDSTYVLKGITEWLAGWKRNGWKTASK
                     QPVKNAELWQRLEAEAQRHGTVEWNWVKGHAGHPENERADKLACRGRDENR"
     gene            4689..4832
                     /locus_tag="INP57_RS12295"
                     /old_locus_tag="INP57_12295"
     CDS             4689..4832
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="INP57_RS12295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="INP57_12295"
                     /product="hypothetical protein"
                     /protein_id="WP_200070266.1"
                     /transl_table=11
                     /translation="MGVLIAKDIAAARAEKLELSKAEQQVIAHLVREHQQQDQQRTGAA
                     KR"
     gene            5001..6242
                     /locus_tag="INP57_RS12300"
                     /old_locus_tag="INP57_12300"
     CDS             5001..6242
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.5"
                     /locus_tag="INP57_RS12300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_12300"
                     /product="YcaO-like family protein"
                     /protein_id="WP_200070267.1"
                     /sec_met_domain="YcaO (E-value: 6.7e-50, bitscore: 165.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTIDGDQHAQAGERSCDWRTALSNGERAVRRFGWTAELDPLGDD
                     PALWRCVLHDRNGEPVPSGAGSGKGYRLPAQVGAIFEALEHHFGREQHKTPDIVLRSAR
                     EAATELTGDVVGARLAEGPDEPIACLPFRNLSDDAATLLPAFLTSPDYVSDAFEPERRE
                     LGDTYDYAGVLRYSLNSGCAAGSTREEATVHAINEIVERDAFSLMLINTFLAASPAPLT
                     VVDPATLPDNLAELHGIARQRSGGSVQLIDMTTSLGIPAVLAYLPPQPGEPARVRGAGA
                     SLSREHAIRRALIELLQLMAGSTQREDEDKERDWTAEYPPFHDCYLMNLGPRLLEAEVV
                     PYAPTIAPGAPDGHLERLVRILTSHGFTPLVRELHTSAELTVVSTVVPGLERFMVITDG
                     QLVVPGPRGLAARP"
     misc_feature    5011..5024
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     gene            complement(6298..7257)
                     /locus_tag="INP57_RS12305"
                     /old_locus_tag="INP57_12305"
     CDS             complement(6298..7257)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671078.1"
                     /locus_tag="INP57_RS12305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_12305"
                     /product="electron transfer flavoprotein subunit alpha/FixB
                     family protein"
                     /protein_id="WP_200070268.1"
                     /transl_table=11
                     /translation="MSEVLVLVDHAGGEVKKVTAELLTAARRIGEPSAVVVGEPGTADK
                     LKGALASQGAEKVYVAESADAGGYLVTPSVEVLASLVGSASPAAVLVPGSVDGKEIAGR
                     LAVKLGSGLLSEVVDIDGDGVGSHSLFGGTYNAKAKVASGTPVVTVLPGSVDAEPTAGA
                     GAEQAVEVPALDGSKNAKITGTQPVEAGDRPELTEASVVVSGGRGVGSAESFEVVETLA
                     DSLGAAVGASRAAVDSGYYPHQFQVGQTGKTVSPQLYIALGISGAIQHRAGMQTSKTIV
                     AVNKDAEAPIFEIADYGVVGDLFKVAPQLTEEVGKRKG"
     gene            complement(7289..8071)
                     /locus_tag="INP57_RS12310"
                     /old_locus_tag="INP57_12310"
     CDS             complement(7289..8071)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009944358.1"
                     /locus_tag="INP57_RS12310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_12310"
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="WP_200070269.1"
                     /transl_table=11
                     /translation="MNIVVLVKQVPDTWSERKLADSDHTLDRESADAVLDEINERAVEE
                     ALLIKEAQGGEVTAVCMGPDRATDAIRKALSMGADKAIHLSDEALHGSDAVQTAKALAK
                     VIGTVESVDLVIAGNEATDGRVGAVPAMLAELLGQPQLTYARKVSTDGSTVSIERETDA
                     GVVSLEANLPAVVSVTEKINEPRYPSFKGIMAAKKKPVSALTLADAGIDPSEVGLANAG
                     SQVTESAPKPPKEAGQRVNDEGDGGTKIVEFLAAEKLV"
     misc_feature    8167..8177
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            8355..9200
                     /locus_tag="INP57_RS12315"
                     /old_locus_tag="INP57_12315"
     CDS             8355..9200
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015104598.1"
                     /locus_tag="INP57_RS12315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_12315"
                     /product="DegV family protein"
                     /protein_id="WP_200070270.1"
                     /transl_table=11
                     /translation="MNNRVALVTDSTASIPVDVADKLGICVVQLELKLGELENDERRIP
                     HPDLAQAMRDGVAVETSPPPPPAFFWNYTDAVSAGVESIVSVHISEGLSQTCDSARSAA
                     AEINLPVYVVDSRLCGLGIGYPVIAAAEAAAAGAGTQGVLSVLDRRLRSTTQMIYVDTL
                     EYLRRSGRVGRAQALLGSALSIKPVLVLREGVLEPMVKGRGPDRALKKAVRQAAQRAGN
                     GPVDIGIEHFQYADRANEVAEQLRAAVPQARRVVIAETSAIIGAHAGPGALGLTVSPVV
                     "
     misc_feature    complement(8394..8407)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            9256..10737
                     /locus_tag="INP57_RS12320"
                     /old_locus_tag="INP57_12320"
     CDS             9256..10737
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644165.1"
                     /locus_tag="INP57_RS12320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="INP57_12320"
                     /product="glycoside hydrolase family 57 protein"
                     /protein_id="WP_200070271.1"
                     /transl_table=11
                     /translation="MTEPIGAFCLVLHSHLPWLAGHGSWPVGEEWLHQAWAHCYLPLAG
                     MLERFAAEGRRDVLTLGITPSLAAGLDDPRCLRSFHHWLGNWRLRSHEAAARWRGDPVL
                     RELAAAEHRAAGERLAEFGARWRHGASPVLRPLIESGTVELLGGPATHPFQPMLEPEMR
                     DFALQIGLNDAELRWGVRPDGIWAPECAHRPGMEREYAAAGVRRFLVDGGALEDVSVAH
                     PVGGDVLCFGRDVALSEEVWSATGYPAHSDYRDFHTFDHAVGLKPARITGRDVDPGDKE
                     PYDPARAAAAVDGHAREFVSAVTNRLAQRGGLVVAAFDTELFGHWWFEGPSWLEKVLRA
                     LPAAGVRVTTLRGAVQAGHVGAPVQLPETSWGVGNDWRTWCGDAVSDIAEANRALQERA
                     LRHLRRVPGSAARDPVRDQLLREVLLALASDWAFMISHETGADYARGRARLHAARAHRL
                     VDLVERGAHAEAAEFARGLRSQDGIFGHLDARSLR"
ORIGIN
        1 cagcagcagg tccagcggca ccaccccggc ggtggcggca ccgggccggg acatcgcggc
       61 cacgagcact ccgcccagcc ccaccagcag cgcctgcccg agcatgtccg agagctgcag
      121 cgcggccgag ttgaacccgc gccgctgcgg ttccgacagc gacagcaccc ggaccgaggt
      181 gctggagatc gcgatgccca tgcccgcacc gcccagcgac cacagcccga acaccgccca
      241 cgcgggcccc cagaccggcg cgatcagcac cagtccggcg accgcggtag ccaccagcag
      301 cagaccggcg ccgaccaggt actcccgccg gatatcgcgc cgggagctct ggaagaacgc
      361 gccggccgac cagcccaatg atccgacggt gagcggaatt ccggccgtgg caggcgagta
      421 gccgtgcacg accgacagcg tcagcggcac gaacgcctgc gcggtgatga acacccccgc
      481 gagcagcccg cgcgcgagca ccatcaccgg aatcccggac tgcccgctga aggtgccgcg
      541 cggcagcagc attcgcagcg acggagccag cacgaccagc gccacggcgc cgatcaccac
      601 gaccggcacg gaggtgttcc cgtccgtcgc ggtctgcgcc gcccagttca ccccgacgac
      661 cccggccgca gcacccaccg cagccagcgg caatcccggc gcaccggccg gggatgcggt
      721 ctcaccggcc ccgagccgcc gcaccgtcgg caccagcagc aacgccccca ccagcatcaa
      781 cggcgcgagc ccgaggaagg tccagcgcca gctgaggtgc tcggtgagca accccgtgat
      841 cgcgggcccg accagcgcgg gcaccaccca ggccgcggac agcgcaccga acgcggcagg
      901 ccgatcccgc tccgggtaga ccctggcgat cagcacgtac agcgccacga tctgcccacc
      961 ggcgccgatg ccctgcatgg cgcgcgccac cagcaggctc ggcatgtccg gggcgaatcc
     1021 ggcgatcagc agcccgaggc cgaaggtcgg catcgccacc agcaacggcg cccctgggcc
     1081 gcggcggtcg gcgatgcgcc cgccgacgac gttgccgatc gcgctcgccg ccaggaagac
     1141 ggtgaacggc cacgagtacc actgctcggc gtgcagctcg cgcacgatcg tcggcagggc
     1201 ggtgccgatg cccatcgcct cgaacgcggc caacgtgatc accaggacca ggccgatggt
     1261 gaagttccgc cgccccgggc tccacaaggc gctttctgag gttccgtcaa cgcgcacccg
     1321 gcgagcctgc aacttgcacg ggggtacaag tccagcgaag tcgcccgcac gggcgcaacg
     1381 cctggttcaa tcgcgcccgg gatgcgcact ttcggcgaag gagagcaccg atgcccgagg
     1441 tcgagcagca gatcaatgcc gtcacccgca cggtgggcac tcgcgaactc gaagcaggca
     1501 cggcgaacgt cgtgacgatc gcgcagagct gcccggcgcc cgtggcggac gtctgggacg
     1561 cctgcaccaa cgccgagcgg attccccggt ggttcatgcc gatcagcggt gacctgtccg
     1621 aaggcggccg ctaccagctg gagggcaacg cgggcggcac cgtgcagcgc tgcgacccgc
     1681 cgaacggctt cgacgcgacc tgggagttcg gcggcgcgac gagctggatc gaggtgcggc
     1741 tgaccgccga ggacgcgagc agcacgcgga tggagctgcg ccacatcgaa ctcgacaacg
     1801 acaactgggc cgagtacggg ccgggagccg tgggcgtcgg ctgggacatg gggctgctcg
     1861 ggctcgcggt gcacttcacc ggcgactcgg cgtacggggc ggaatggatc gggtccgcgg
     1921 agggcagccg gttcgcgtgg ctcagcagca aggcgtggtg cgcggcgaac atcgccgccg
     1981 gaacgccgga ggcgcaggcc acggcgtgcg cggatcgcac gacggcggcc tacaccgcac
     2041 cgccggaagg gtcctgagcc cgcgggtgac cgcccgggct cacgccgccg cgggctgcgg
     2101 caggtgcggg aggtgcggct cggcgggtgc ggtgacctct gccacggcgc gttcggtgcg
     2161 gcgagccagt tcccggcgat cgccaaccgc ggccgcgtcc atctcgggca gcagcgacag
     2221 ctccaccacc agatcccgga cccgagccac cgcgagcacg gattccagca gcgtcgcctc
     2281 gccgacgaac gccgcagcgg tcgtcggccg cccaccggcg ctgaaccgca gcgccaccgg
     2341 ctgcaccggc acccgcgcgt ccaccgccgc ctggaacacc gcgggccggt acctgccgga
     2401 cgcgagaccg caccacgtgg tgccttccgg gaaggctccg accacggcgc cgccgcgcag
     2461 cgagtcggcg atcgtgcgca ccgccccggg cagcgcggac aaccgctccc ggtcgatgta
     2521 gagggtgccg acgcgcccgg ccagcggccc gatcaccggc caggaccgca cctcggtctt
     2581 ggccagcagc cgcatcgggc gcaccgccat cagcgcgacc acgtcgagcc acgaaacgtg
     2641 gttggtgacc accaacgccc cggaatcgag ccggtgctca ccgcgcaccg cgaaccggat
     2701 gcccagcacc cgcagcagcg cccggaacca cgaccgcacc agcgcagtgc gcgcggaccg
     2761 ccacagcagc gcgaacacca ccgcgacccc gatgcccgcg agcatcagcc cggcggcccc
     2821 ggccagccgc agcgccacgc ggtgcgttcc cgcgcggcgc accgaccccg gcctgggcag
     2881 gcagcccggg ccgcacggcg aatccggcgc ccatctgtgc gtcatgccgc ggcaccgagg
     2941 aagaaccgca ggtagcgcgg gtcgatccgg gtgaagtcga gcagcacaaa gaagtccgcg
     3001 accccgaact ccgggtcgtg cgcgggccgc ccgcacacct gcgcgccgag ccgcaggtag
     3061 cccttcagca gcgggggcag cggaccgcgg tgggtgcgct cgacgggttc cgggttccac
     3121 ggcaggtacg gctgcacccg cgagtcctcc ggcgcgtagt gcttcgccga aaccgtgtcc
     3181 cacaccttcg ccgcgagcgc gccgccgtcg tccagcggca ccgaggcgca cccggcgagc
     3241 caggtgtgcc cgtggagcag catgtagcgg gcgattccgg cccacaccag gctcaccacg
     3301 ccgccggttc ggtggtcgcg gtgcacgcag gaacggccgg tttccaccag ggcggggcgc
     3361 agttccccga gcgcggacag gtcgaactcg gtctcggagt agagcccgcc cgcttcccga
     3421 gcgcgctccg gcggcagcat ccggtaggtg ccgacgactt cgccggtgcg gtcgtcgcgg
     3481 acgatcaggt ggtcgcagtg ctcgtcgaac ggatcggtct ccacgcccgg cgcgtcgccg
     3541 tgcacggtgg cgcccatctc ttcggcgaac acttcgtagc gcagccgctg cgcggcccgc
     3601 acctcgtcgc tgtcccgggc cacgagcagc gaatagggag tggtggcagt ggtcggagat
     3661 cccgctggag cggtgctggc aagcagcgtc gactcggaca tgcccgcagg tgtatcgccg
     3721 cgcgcagaaa gcgcagtagg accgctgagg acacgcaata ggaattttcg gtgaatgccc
     3781 ggtacttacc gcactggcct gccctgaccg gcccaacgaa caccgcatcc cggaagttcc
     3841 cgcgcccccg gagttctcca agcgaacgga ccgctcgtcc cacaagactg gtcgaacgtg
     3901 ccgttcactc ggcgcgaaag ctccccggca gaacgacgcg tgcgcgtgtc gcgcgggagt
     3961 ctcgtggtcc gcgggtgacc ggggtggcgg gccgggttcg cccgcgcgct aggttgcggg
     4021 gatgccgcag caggacgaag ccggggcgcg cgaccgcgtc gagttgttca ccgatggcgc
     4081 gtgcagcggc aatcccggcc cgggcggctg gggcgtggtg ctgcgctacg gaacgcacga
     4141 gcgcgagctc cacggcggtg agccgggcac cacgaacaac aagatggaac tcaccgcggt
     4201 catcgaaggg ctcgcggcgc tgacccgccc gatgccggtg gtgctggtgc acaccgacag
     4261 cacctacgtg ctcaagggca tcaccgaatg gctcgcgggc tggaagcgca acggctggaa
     4321 gaccgcgtcc aagcagccgg tgaagaacgc cgagctctgg caacggctgg aagccgaagc
     4381 gcagcggcac ggcaccgtcg agtggaactg ggtcaagggc cacgccgggc acccggagaa
     4441 cgagcgcgcc gacaagctcg cctgccgcgg ccgcgacgag aatcgctgag aactcgcacc
     4501 ggcgcggaat ttcgcgcgcc gcaacggatt cggcagaacc ggaccgaaaa cagcacattt
     4561 gcggaatgtg ctacttccgt cgtagtccat ccgaatgcgc cccgttgacg cgatctcgcc
     4621 cacccgcgca aactccgaat gcgcacaatg ggctcatcgc ccgcgtcgac cccgcaacgg
     4681 aggaaaaaat gggtgttctc attgccaagg atattgccgc cgcacgagcg gaaaagctcg
     4741 aactgtcgaa ggccgagcag caggtgatcg cgcacctcgt tcgcgagcac cagcagcagg
     4801 accagcagcg gaccggcgca gcaaagcgct gacgacgtgg gcacccggcg caagcggcac
     4861 acctcgccgg gtgcccggcc gaaatccacc acgcagccga ccgtgcggtt tcagcaacga
     4921 ttcctgttca gcgcgaacga attgtccgcg aatcgcttgc accgctccca cgaacactcg
     4981 atcaaaagcg aggcgttgca ttgcgcacca tcgacggaga tcagcacgcg caagccggtg
     5041 agcggtcctg cgactggcgg acggcgctgt cgaacggcga gcgagccgtc cggcggttcg
     5101 ggtggaccgc agaactcgac ccgctcggcg atgaccccgc gctgtggcgg tgcgtcctgc
     5161 acgaccgcaa cggcgagccg gtgccgagcg gagcaggctc cggcaaggga taccggctgc
     5221 ccgcccaggt cggggcgatc ttcgaggcgc tggagcacca cttcggccgc gagcagcaca
     5281 agacccccga catcgtcctg cgctcagcgc gcgaagccgc caccgagctg accggtgatg
     5341 tcgtgggcgc ccgcctcgcg gaaggccccg acgagccgat cgcctgcctg ccgttccgga
     5401 acctgtccga cgacgcggcg accctgctgc cggcgttcct gacgtctccc gactacgtca
     5461 gcgacgcctt cgagccggaa cgccgcgaac tcggcgacac ctacgactac gcgggcgtgc
     5521 tgcgctattc gctcaacagc ggctgcgcgg cgggttccac gcgggaagag gccaccgtcc
     5581 acgcgatcaa cgagatcgtg gagcgcgacg ccttctcgct gatgctgatc aacacgttcc
     5641 tcgccgcaag cccggcgccg ctgaccgtcg tcgaccccgc tacccttccc gacaacctcg
     5701 ccgaactgca cgggatcgcg cggcaacgca gcggcgggag cgtgcagctc atcgacatga
     5761 cgacgagcct cggaatcccc gccgtgctcg cttacctccc gccgcagccc ggtgaaccgg
     5821 cgcgagtgcg cggtgcaggc gcgtcgttgt cccgcgagca cgccatccgg cgggcgctga
     5881 tcgagctgct gcaactaatg gcgggcagca cgcaacgcga agacgaagac aaggaacggg
     5941 actggaccgc cgagtacccg ccgttccacg actgctacct gatgaacctc ggcccgaggc
     6001 tgctcgaagc cgaggtggtg ccgtacgcac cgaccatcgc cccgggcgct ccggacggcc
     6061 acctggaacg gctcgttcgc atcctcacct cgcacggctt caccccgctc gtgcgcgagc
     6121 tgcacaccag cgcggagctg accgtggtca gcaccgtcgt gccaggactc gaacgcttca
     6181 tggtgatcac cgacggccaa ctggtcgttc ccggtccgcg cgggctcgcc gcccggccct
     6241 gagacgaaaa agcgggccgc gcccgaatgg acgcggcccg ccgaagcgtt cgagcgctca
     6301 gcccttgcgc ttgccgacct cctcggtcag ctgcggggcg accttgaaca ggtcgccgac
     6361 gacgccgtag tcggcgatct cgaagatcgg ggcctcggcg tccttgttga ccgccacgat
     6421 cgtcttcgag gtctgcatcc cggcgcggtg ctggatcgca cccgagatgc ccagcgcgat
     6481 gtacagctgc ggcgacacgg tcttgccggt ctggccgacc tggaactggt gcgggtagta
     6541 accggagtcc accgccgcgc gcgaggcgcc aaccgcggca cccagcgagt cggcgagggt
     6601 ctccacgacc tcgaacgact cggccgaacc gacaccgcga ccaccggaga cgaccacgct
     6661 ggcctcggtc agctcgggcc ggtccccggc ctccaccggc tgcgtgccgg tgatcttcgc
     6721 gttcttcgaa ccgtccagcg cgggcacctc gacggcctgc tccgcaccgg caccggcggt
     6781 cggctcggcg tccacgctgc ccggcagcac ggtgaccacc ggcgtaccgg aggcgacctt
     6841 ggccttggcg ttgtaggtac cgccgaacag cgagtggctg cccacgccgt cgccgtcgat
     6901 gtcgacgacc tcggacagca gaccggagcc gagcttgacc gcgagccgcc cggcgatctc
     6961 cttgccgtcc accgaacccg gcaccagcac cgcggccggc gacgccgaac ccaccagcga
     7021 ggccagcacc tccaccgacg gggtcaccag gtagccgccc gcgtccgcgg actcggcgac
     7081 gtagaccttc tccgcgccct gcgacgccag cgcgcccttg agcttgtcgg cggtgcccgg
     7141 ctcaccgacc accaccgccg acggctcacc gatacgccgc gccgcggtca gcagctcggc
     7201 ggtgaccttc ttcacctcgc caccggcgtg gtcgacgagg accagaacct cagacatgac
     7261 tttgactctc ctcgcgaaac cagtggactc agacgagctt ctcggcggcc aggaactcga
     7321 cgatcttggt gccgccgtcg ccctcgtcgt tgacgcgctg accggcttcc ttcggcggct
     7381 tcggcgcgga ctcggtcacc tgcgaaccgg cgttggccag cccgacctcg gacgggtcga
     7441 tgcccgcgtc ggccagcgtc agcgcggaga ccggcttctt cttggccgcc atgatgccct
     7501 tgaacgaggg gtagcgcggc tcgttgatct tctcggtgac cgacacgacc gcgggcaggt
     7561 tcgcctccag gctcaccaca ccggcgtcgg tctcgcgctc gatgctcacg gtcgaaccgt
     7621 cggtggagac cttgcgggcg taggtcagct gcggctgccc cagcagctcg gccagcatcg
     7681 ccgggaccgc gcccacgcgg ccgtcggtgg cctcgttgcc cgcgatcacc aggtccaccg
     7741 actcgacggt gccgatgacc ttggccagcg ccttcgcggt ctgcaccgcg tcggagccgt
     7801 gcagcgcctc gtcggacagg tggatcgcct tgtccgcacc catcgacagc gccttgcgga
     7861 tggcgtcggt cgcgcgatcc ggacccatgc acacggcggt cacctcgccg ccctgggcct
     7921 ccttgatcag cagcgcctct tccaccgcac gttcgttgat ctcatccagc acggcgtccg
     7981 ccgactcgcg gtcgagcgtg tggtcggagt cagcgagttt gcgctcggac cacgtatcgg
     8041 gcacctgctt caccaggacg acgatgttca tgggtcctct tcgacctcct gcggactgac
     8101 gacgactcat acgtgcttgc ggggttccgg ccgacggttg cgcatcgtta ccgggaagtt
     8161 cgaccttgcc acgtcacagt gtcggtggca cagtgacgcc aaccaccccg gatgttactt
     8221 gtcggtagcc ccggtgcaac cagcgtatcc cgtgacagta ctcacttact ccgtcgactc
     8281 cgataccgcg gtgagtaccg ccacctacag aaaccacatc cagaagcgaa catctcggga
     8341 ctagcctgca cgccatgaac aaccgcgtcg ccctcgtgac ggactcgacc gcttcgatcc
     8401 cggtcgatgt cgccgacaaa ctggggatct gcgtcgtaca gctcgaattg aagctcggcg
     8461 agctggagaa cgacgaacgc cgaatcccgc accccgacct ggcgcaggcc atgcgcgacg
     8521 gcgtcgcggt cgagaccagc cctcccccgc cgcccgcctt cttctggaac tacaccgacg
     8581 cggtctcggc gggcgtcgag tcgatcgtgt cggtgcacat ctccgaaggt ctctcgcaga
     8641 cctgcgactc cgcgcgcagc gccgccgccg agatcaacct gccggtgtac gtggtggact
     8701 cccggctgtg cgggctggga atcggttacc cggtgatcgc cgccgccgaa gccgcggcgg
     8761 ccggggcggg tacccagggc gtgctctcgg tgctggaccg gcggctgcgc agcaccacgc
     8821 agatgatcta cgtggacacc ttggagtacc tgcgccgcag cgggcgcgtc ggccgggcgc
     8881 aagcgctgct gggcagcgcc ctgtcgatca aaccggtgct ggtgctgcgg gaaggcgtcc
     8941 tggaaccgat ggtcaagggc cgcggcccgg accgggcgct gaagaaggcc gtgcggcagg
     9001 ccgcgcagcg cgccgggaac gggccggtcg acatcggcat cgagcacttc cagtacgccg
     9061 accgcgccaa cgaggtggcc gagcagttgc gcgccgcggt gccgcaggcg cggcgggtcg
     9121 tgatcgccga gaccagcgcg atcatcggcg cgcacgccgg acctggcgcg ctcggcctca
     9181 cggtctcgcc ggtggtgtga acgcactcgc cggtcgctcg cggcggcgct gctgcggcgg
     9241 tcgtagtgtc tccgcgtgac cgaaccgatc ggcgcgttct gcctggtgtt gcacagccat
     9301 ctgccgtggc tcgccgggca cggcagctgg ccggtcggag aggaatggct gcaccaggcg
     9361 tgggcgcact gctacctgcc gctggcgggg atgctggagc gcttcgccgc cgaaggccgc
     9421 cgggacgtgc tcacgctggg gatcacaccg tcgctggccg cggggctgga cgatccgcgc
     9481 tgcctgcggt ccttccacca ctggctgggg aattggcggc tgcgcagcca cgaagcggcg
     9541 gcgcgctggc gcggcgaccc ggtgctgcgg gaactggccg cggccgagca ccgcgccgcg
     9601 ggtgagcggc tggccgagtt cggggcgcgg tggcggcacg gcgcttcgcc ggtgctgcgg
     9661 ccgctgatcg agtccgggac ggtcgaactg ctcggtggtc ccgccacgca tcccttccag
     9721 ccaatgctcg aaccggaaat gcgggatttc gcgctgcaga tcggactaaa cgacgcagaa
     9781 ctgcgatggg gcgtgcggcc ggacggaatc tgggcgccgg aatgcgcgca ccggcccgga
     9841 atggagcggg agtacgcggc ggccggggtg cggcgattcc tggtggacgg cggcgcgctg
     9901 gaggatgttt cggtggcgca cccggtcggc ggcgatgtgc tgtgcttcgg ccgcgacgtc
     9961 gcgctcagcg aggaggtttg gtcggccacc ggctatccgg cgcattccga ctaccgcgac
    10021 ttccacacgt tcgaccacgc cgtggggctc aaaccggcgc ggatcaccgg gcgcgacgtg
    10081 gatcccgggg acaaggagcc gtacgacccg gcgcgagccg ccgcggcggt cgacggccac
    10141 gctcgcgagt tcgtctcagc ggtcacgaac cggttggcgc agcgcggcgg gctggtcgtg
    10201 gcggccttcg acaccgagct gttcgggcac tggtggttcg agggtccgtc atggctggag
    10261 aaggtgctgc gcgcgttgcc tgcggcggga gtgcgcgtga cgacgctgcg cggggccgtg
    10321 caagccggtc acgtcggtgc gccggtgcag ttgccggaaa cctcgtgggg cgtgggcaac
    10381 gactggcgga cgtggtgcgg cgacgcggtc tccgacatcg ccgaggcgaa ccgggcgctg
    10441 caggaacggg cgctgcggca cctgcggcgc gttcccggct cagcagcgcg cgatccggtg
    10501 cgggaccagt tgttgcgcga ggtgctgctg gcactggcaa gcgactgggc gttcatgatc
    10561 agccacgaga ccggtgcgga ttacgcgcgc gggcgcgcgc ggctgcacgc ggcacgggcg
    10621 caccggctcg tcgatctggt ggagcgcggt gcgcacgccg aagcggccga gttcgctcgc
    10681 gggctccggt cgcaggacgg gatcttcggg cacctcgacg cacgctcgtt gcggtagtgc
    10741 ccgcgcggat cgagtgatca tgcgcggccg ggcccggcgt gcaaacgtcc tgttccggga
    10801 gctgccggaa ggaatctcat ctcatgcgcg tgctgatgct gtcctgggaa tacccgccgg
    10861 tcgtcgtcgg cggactcggc cgccacgtgc acgcgctggc ccggcacctc gccgcgcagg
    10921 gccacgaagt cgtcgtgctg tgcaggcagg ccggcggcac ggatgcctcg acgcatcccg
    10981 gtaccgacgc ggtcgccgat ggcgtgcggc tggtgcgggc cgccgaggac ccgccgcacc
    11041 tgaccttcga gcacgacctg gtggcgtgga cgctggcgat gggtcacgcc atgctccgcg
    11101 ccggctaccg gttgctgcgg gaatggtgcc cggacgtggt gcacgcgcac gactggctgg
    11161 tcacgcaccc ggcgatcgcg ctcgccgacg cctgctcggt gccgctggtg gcgaccgtgc
    11221 acgccaccga agcgggcagg ca
//
