Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP066711.1 (Staphylococcus pseudintermedius)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | NI-siderophore | 692,236 | 725,235 | High | staphyloferrin A | other:non-nrp siderophore
Region 2 | cyclic-lactone-autoinducer | 854,082 | 874,787 |
Region 3 | RiPP-like | 913,140 | 924,183 |
Region 4 | terpene-precursor | 1,335,769 | 1,356,650 |  |
Region 5 | lanthipeptide-class-iii | 1,639,213 | 1,661,732 |
Region 6 | RiPP-like | 2,145,244 | 2,157,394 |
Region 7 | NI-siderophore | 2,230,939 | 2,265,383 | High | staphyloferrin B | other:other
Region 8 | azole-containing-RiPP | 2,373,619 | 2,395,671 |
Region 9 | opine-like-metallophore | 2,519,566 | 2,541,682 | High | staphylopine | other:other

NZ_CP066711.1 - Region 1 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 692,236 - 725,235 nt. (total: 33,000 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
JGZ56_RS03025: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000944.5 |  | 0.79 | other (non-nrp siderophore) | staphyloferrin A | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.3 |  | 0.56 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000939.5 |  | 0.56 | other (other) | aerobactin | Grimontia hollisae
BGC0000947.5 |  | 0.54 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002682.2 |  | 0.53 | other (other) | aerobactin | Vibrio mimicus
BGC0002073.3 |  | 0.52 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0002683.2 |  | 0.49 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0000943.5 |  | 0.47 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001948.3 |  | 0.43 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0002681.3 |  | 0.41 | other (other) | rhizoferrin | Francisella tularensis subsp. tularensis SCHU S4

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000944.5 |  | 0.79 | other (non-nrp siderophore) | staphyloferrin A | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.3 |  | 0.56 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000939.5 |  | 0.56 | other (other) | aerobactin | Grimontia hollisae
BGC0000947.5 |  | 0.54 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002682.2 |  | 0.53 | other (other) | aerobactin | Vibrio mimicus
BGC0002073.3 |  | 0.52 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0002683.2 |  | 0.49 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0000943.5 |  | 0.47 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001948.3 |  | 0.43 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0002681.3 |  | 0.41 | other (other) | rhizoferrin | Francisella tularensis subsp. tularensis SCHU S4

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.07 out of 26.06
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.84 out of 29.38
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.17 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.41 out of 29.38
Confidence: medium
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 27.02 out of 32.74
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.40 out of 21.55
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.29 out of 24.78
Confidence: medium
Additional weak hits (1):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.03 out of 32.74
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CRP | Cyclic AMP receptor protein
FuR variant 1 | Ferric Uptake Regulator
FuR variant 2 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_CP066711.1 - Region 2 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 854,082 - 874,787 nt. (total: 20,706 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: kinase
JGZ56_RS03795: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Hydrolases: deacetylase
JGZ56_RS03855: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Lyases: hydratase
JGZ56_RS03825: Nitrilase/cyanide hydratase and apolipoprotein

smcogs
  SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002667.2 |  | 0.45 | ribosomal | estericin A | Clostridium estertheticum
BGC0001291.3 |  | 0.45 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0002313.3 |  | 0.40 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0002579.2 |  | 0.39 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000540.5 |  | 0.39 | ribosomal | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0001687.3 |  | 0.39 | other (other) | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001171.5 |  | 0.38 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000882.5 |  | 0.38 | other (other) | mildiomycin | Streptomyces rimofaciens
BGC0001484.3 |  | 0.36 | other (other) | 2'-chloropentostatin, 2'-amino-2'-deoxyadenosine | Actinomadura sp. ATCC 39365
BGC0000019.5 |  | 0.35 | PKS | angolamycin | Streptomyces eurythermus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002667.2 |  | 0.45 | ribosomal | estericin A | Clostridium estertheticum
BGC0001291.3 |  | 0.45 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0002313.3 |  | 0.40 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0002579.2 |  | 0.39 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000540.5 |  | 0.39 | ribosomal | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0001687.3 |  | 0.39 | other (other) | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001171.5 |  | 0.38 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000882.5 |  | 0.38 | other (other) | mildiomycin | Streptomyces rimofaciens
BGC0001484.3 |  | 0.36 | other (other) | 2'-chloropentostatin, 2'-amino-2'-deoxyadenosine | Actinomadura sp. ATCC 39365
BGC0000019.5 |  | 0.35 | PKS | angolamycin | Streptomyces eurythermus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26
Confidence: strong
Additional weak hits (1):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.05 out of 27.55
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein

NZ_CP066711.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 913,140 - 924,183 nt. (total: 11,044 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001100.5 |  | 0.25 | NRPS, PKS | lankacidin C | Streptomyces rochei
BGC0002713.2 |  | 0.25 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0002122.2 |  | 0.23 | NRPS | gramicidin S | Aneurinibacillus migulanus
BGC0001214.5 |  | 0.20 | NRPS | marformycin A, marformycin B, marformycin C, marformycin D, marformycin E, marformycin F | Streptomyces drozdowiczii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001100.5 |  | 0.25 | NRPS, PKS | lankacidin C | Streptomyces rochei
BGC0002713.2 |  | 0.25 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0002122.2 |  | 0.23 | NRPS | gramicidin S | Aneurinibacillus migulanus
BGC0001214.5 |  | 0.20 | NRPS | marformycin A, marformycin B, marformycin C, marformycin D, marformycin E, marformycin F | Streptomyces drozdowiczii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.38 out of 27.78
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.25 out of 20.97
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.36 out of 29.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.13 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.65 out of 28.19
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.21 out of 32.93
Confidence: medium
Additional weak hits (1):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.45 out of 30.97
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3 | Repressor of DNA damage response
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP066711.1 - Region 4 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,335,769 - 1,356,650 nt. (total: 20,882 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
JGZ56_RS06445: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: carboxylase
JGZ56_RS06390: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase
JGZ56_RS06375: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthase synthetase
JGZ56_RS06415: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

JGZ56_RS06420: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000234.5 |  | 0.42 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000677.5 |  | 0.41 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0002591.2 |  | 0.41 | PKS, terpene | aurachin C, aurachin D, aurachin SS | Streptomyces sp.
BGC0002284.3 |  | 0.40 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000905.5 |  | 0.39 | other (other) | heme D1 | Heliobacillus mobilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000234.5 |  | 0.42 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000677.5 |  | 0.41 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0002591.2 |  | 0.41 | PKS, terpene | aurachin C, aurachin D, aurachin SS | Streptomyces sp.
BGC0002284.3 |  | 0.40 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000905.5 |  | 0.39 | other (other) | heme D1 | Heliobacillus mobilis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
JGZ56_RS06415: PT_FPPS_like
Domain 1 (29 - 292): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.46 out of 24.78
Confidence: strong
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.58 out of 23.05
Confidence: strong
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
LexA variant 2 | Repressor of DNA damage response
PerR | Peroxide regulator

NZ_CP066711.1 - Region 5 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,639,213 - 1,661,732 nt. (total: 22,520 nt) Show pHMM detection rules used
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002700.2 |  | 0.50 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0002111.3 |  | 0.47 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000519.4 |  | 0.44 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000553.3 |  | 0.42 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000518.3 |  | 0.40 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0002701.2 |  | 0.38 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0001209.3 |  | 0.36 | ribosomal | streptide | Streptococcus thermophilus LMD-9
BGC0000546.3 |  | 0.33 | ribosomal | SAL-2242 | Streptomyces albidoflavus
BGC0000472.4 |  | 0.28 | ribosomal | anacyclamide A10 | Anabaena sp. 90
BGC0000565.5 |  | 0.28 | ribosomal | goadsporin | Streptomyces sp. TP-A0584

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002700.2 |  | 0.50 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0002111.3 |  | 0.47 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000519.4 |  | 0.44 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000553.3 |  | 0.42 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000518.3 |  | 0.40 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0002701.2 |  | 0.38 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0001209.3 |  | 0.36 | ribosomal | streptide | Streptococcus thermophilus LMD-9
BGC0000546.3 |  | 0.33 | ribosomal | SAL-2242 | Streptomyces albidoflavus
BGC0000472.4 |  | 0.28 | ribosomal | anacyclamide A10 | Anabaena sp. 90
BGC0000565.5 |  | 0.28 | ribosomal | goadsporin | Streptomyces sp. TP-A0584

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for JGZ56_RS07820

JGZ56_RS07825
Leader:
MNKILDLQKIENETLTQRE
Core:
K G G R G L S T L L S F L G G S T I S N H C
Core with dehydrations:
K G G R G L Dha Dhb L L Dha F L G G Dha Dhb I Dha N H Cys

#### antiSMASH-DB 4.0 matches for JGZ56_RS07825

100.0%
NZ_CP066711.1:
Lanthipeptides: JGZ56_RS07825_lanthipeptide
1
K G G R G L S T L L S F L G G S T I S N H C
22
K G G R G L S T L L S F L G G S T I S N H C
1
K G G R G L S T L L S F L G G S T I S N H C
22
50.0%
NZ_GL545262.1:
Lanthipeptides: HMPREF0798_RS11830_lanthipeptide
5
G L S T L L S F L G G S T I S N H C
22
+S T L++F L S T I S H C
1
S I S T L V A F L--S T I S Q H C
16
40.9%
NC_014551.1 and 13 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide
Lanthipeptides: BAMF_RS41660_lanthipeptide
5
G L S T L L S F L G G S T I S N H C
22
G + L + +G S T I S N C
3
G W T L L T T L I G T S T I S N S C
20
with 24 more sequence matches
Only the first 10 are displayed here.
36.4%
NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide
Lanthipeptides: BAMF_RS41655_lanthipeptide
6
L S T L L S F L G G S T I S N H C
22
L+ + + +G S T I S N+C
2
L T L I T T I V G S S T I S N N C
18
36.4%
NC_014551.1 and 27 others:
NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptide NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptide NZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide
Lanthipeptides: BAMF_RS41670_lanthipeptide
6
L S T L L S F L G G S T I S N H C
22
L+ + + +G S T I S N+C
2
L T L I T T V V G T S T I S N N C
18
36.4%
NZ_CP026010.1 and 18 others:
NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide
Lanthipeptides: BS11774_RS22075_lanthipeptide
6
L S T L L S F L G G S T I S N H C
22
L+ + + +G S T I S N+C
2
L T L I T T I V G T S T I S N N C
18
36.4%
NZ_JAFFJY010000011.1:
Lanthipeptides: JVX89_RS12320_lanthipeptide
8
T L L S F L G G S T I S N H C
22
T ++ +G S T I S N C
6
T T V T T V G L S T I S N G C
20
36.4%
NZ_LN868937.1:
Lanthipeptides: BN2144_RS19915_lanthipeptide
2
G G R G L S T L L S F L G G S T I S N H C
22
G +++ + S T I S N H C
2
A G W W F T S V T L L V T T S T I S N H C
22
31.8%
NC_016109.1 and 2 others:
NC_016109.1 Lanthipeptides: KSE_RS43695_lanthipeptide NZ_CP068437.1 Lanthipeptides: JK628_RS03405_lanthipeptide
Lanthipeptides: KSE_RS43700_lanthipeptide
16
S T I S N H C
22
S T I S N H C
2
S T I S N H C
8
31.8%
NZ_CP068437.1 and 2 others:
NZ_CP068437.1 Lanthipeptides: JK628_RS03400_lanthipeptide NZ_CP068437.1 Lanthipeptides: JK628_RS03395_lanthipeptide
Lanthipeptides: allorf_0778008_0778106_lanthipeptide
12
F L G G S T I S N H C
22
+ S T I S N H C
1
L M E W S T I S N H C
11
31.8%
NZ_JANBBG010000004.1 and 1 other:
NZ_JANBBG010000004.1 Lanthipeptides: allorf_1567737_1567829_lanthipeptide
Lanthipeptides: allorf_1567890_1567982_lanthipeptide
13
L G G S T I S N H C
22
L G S T+S N+C
1
L P G S T V S N N C
10
31.8%
NZ_LN868937.1 and 1 other:
NZ_LN868937.1 Lanthipeptides: BN2144_RS20095_lanthipeptide
Lanthipeptides: BN2144_RS20100_lanthipeptide
3
G R G L S T L L S F L G G S T I S N H C
22
+ + + +G S T I S N+C
2
A K W Y T I F T T L I G T S T I S N N C
21
30.4%
NZ_CP014806.1 and 3 others:
NZ_CP014806.1 Lanthipeptides: ATY39_RS17975_lanthipeptide NZ_CP014806.1 Lanthipeptides: ATY39_RS17970_lanthipeptide NZ_CP014806.1 Lanthipeptides: ATY39_RS17965_lanthipeptide
Lanthipeptides: ATY39_RS17980_lanthipeptide
15
G S T I S N H C
22
S T I S N H C
16
A S T I S N H C
23

#### MIBiG 4.0 matches for JGZ56_RS07825

26.1%
BGC0002111.3 (EVG22_32245):
Lanthipeptide: andalusicin A or andalusicin B
15
G S T I S N H C
22
S T I S N+C
16
A S T I S N N C
23
26.1%
BGC0002111.3 (multiple genes):
Lanthipeptide: andalusicin A or andalusicin B
13
L G G S T I S N H C
22
+ S T I S N+C
14
V W A S T I S N N C
23
allorf_1652598_1652744
Leader:
MKNVLNLQKFESNENMVR
Core:
Q I T P I K A T V E I T M T V Y G L S T I S N K C N K D T R
Core with dehydrations:
Q I Dhb P I K A Dhb V E I Dhb M Dhb V Y G L Dha Dhb I Dha N K Cys N K D Dhb R

#### antiSMASH-DB 4.0 matches for allorf_1652598_1652744

100.0%
NZ_CP066711.1:
Lanthipeptides: allorf_1652598_1652744_lanthipeptide
1
Q I T P I K A T V E I T M T V Y G L S T I S N K C N K D T R
30
Q I T P I K A T V E I T M T V Y G L S T I S N K C N K D T R
1
Q I T P I K A T V E I T M T V Y G L S T I S N K C N K D T R
30
36.7%
NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
7
A T V E I T M T V Y G L S T I S N K C
25
A T+ T T V G S T S N C
8
A T I T T T R T V I G W S T A S N S C
26
36.7%
NZ_JAFFJY010000011.1:
Lanthipeptides: JVX89_RS12320_lanthipeptide
6
K A T V E I T M T V Y G L S T I S N K C
25
K T+T G L S T I S N C
1
K G Y T P T T V T T V G L S T I S N G C
20
with 16 more sequence matches
Only the first 10 are displayed here.
33.3%
NC_014551.1 and 13 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide
Lanthipeptides: BAMF_RS41660_lanthipeptide
14
T V Y G L S T I S N K C N K
27
T+ G S T I S N C N K
9
T L I G T S T I S N S C N K
22
33.3%
NZ_FOHE01000012.1:
Lanthipeptides: BMX40_RS20340_lanthipeptide
1
Q I T P I K A T V E I T M T V Y G L S T I S N K C N K
27
Q+ P T V +T + S T+S N C++
2
Q V G P T I T T V S A I L T T F-W S T V S N N C D R
27
33.3%
NZ_LN868937.1:
Lanthipeptides: BN2144_RS20095_lanthipeptide
11
I T M T V Y G L S T I S N K C N K
27
I T+ G S T I S N C K
7
I F T T L I G T S T I S N N C G K
23
30.0%
NC_014551.1 and 27 others:
NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptide NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptide NZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide
Lanthipeptides: BAMF_RS41670_lanthipeptide
14
T V Y G L S T I S N K C
25
T V G S T I S N C
7
T V V G T S T I S N N C
18
30.0%
NZ_CP086141.1 and 3 others:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
2
I T P I K A T V E I T M T V Y G L S T I S N K C N K D
28
++ I A T V V L T+++ C K
1
V S A I S A T V A S A T A V S A L F T V T S A C T K S
27
30.0%
NZ_LN868937.1:
Lanthipeptides: BN2144_RS20100_lanthipeptide
11
I T M T V Y G L S T I S N K C
25
I T+ G S T I S N C
7
I F T T L I G T S T I S N N C
21
26.7%
NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide
Lanthipeptides: BAMF_RS41655_lanthipeptide
14
T V Y G L S T I S N K C
25
T+ G S T I S N C
7
T I V G S S T I S N N C
18
26.7%
NZ_CP026010.1 and 18 others:
NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide
Lanthipeptides: BS11774_RS22075_lanthipeptide
14
T V Y G L S T I S N K C
25
T+ G S T I S N C
7
T I V G T S T I S N N C
18
26.7%
NZ_FOHE01000012.1 and 1 other:
NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20540_lanthipeptide
Lanthipeptides: BMX40_RS20545_lanthipeptide
12
T M T V Y G L S T I S N K C
25
T+T++ L S T+S N C
6
T V T I F-L S T V S N H C
18
26.7%
NZ_GL545262.1:
Lanthipeptides: HMPREF0798_RS11835_lanthipeptide
15
V Y G L S T I S N K C
25
V+G L S T I S C
10
V F G L S T I S R Y C
20

#### MIBiG 4.0 matches for allorf_1652598_1652744

20.0%
BGC0002111.3 (EVG22_32245)and 1 other:
BGC0002111.3 (multiple genes) Lanthipeptide: andalusicin A or andalusicin B
Lanthipeptide: andalusicin A or andalusicin B
19
S T I S N K C
25
S T I S N C
17
S T I S N N C
23

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.87 out of 32.93
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.87 out of 32.93
Confidence: medium
Additional weak hits (2):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.68 out of 31.73
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.31 out of 25.88
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

JGZ56_RS07825 - Class III
  Cleavage pHMM score: -0.20
  RODEO score: 0
  Monoisotopic mass: 2096.1 Da
  Molecular weight: 2097.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2115.4 Da N = 1
    2133.4 Da N = 2
    2151.4 Da N = 3
    2169.5 Da N = 4
    2187.5 Da N = 5
allorf_1652598_1652744 - Class III
  Cleavage pHMM score: -1.40
  RODEO score: 0
  Monoisotopic mass: 3180.7 Da
  Molecular weight: 3182.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3200.7 Da N = 1
    3218.7 Da N = 2
    3236.7 Da N = 3
    3254.8 Da N = 4
    3272.8 Da N = 5
    3290.8 Da N = 6
    3308.8 Da N = 7

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 3 | Repressor of DNA damage response

NZ_CP066711.1 - Region 6 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,145,244 - 2,157,394 nt. (total: 12,151 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002674.2 |  | 0.50 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001864.3 |  | 0.50 | ribosomal | listeriocytocin | Listeria monocytogenes SLCC2540
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000623.3 |  | 0.48 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001862.4 |  | 0.47 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0001863.4 |  | 0.47 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0001555.4 |  | 0.47 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002586.2 |  | 0.47 | ribosomal | ASM1 | Lactiplantibacillus plantarum
BGC0001861.4 |  | 0.47 | ribosomal | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000590.5 |  | 0.46 | ribosomal | microcin N | Escherichia coli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002674.2 |  | 0.50 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001864.3 |  | 0.50 | ribosomal | listeriocytocin | Listeria monocytogenes SLCC2540
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000623.3 |  | 0.48 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001862.4 |  | 0.47 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0001863.4 |  | 0.47 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0001555.4 |  | 0.47 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002586.2 |  | 0.47 | ribosomal | ASM1 | Lactiplantibacillus plantarum
BGC0001861.4 |  | 0.47 | ribosomal | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000590.5 |  | 0.46 | ribosomal | microcin N | Escherichia coli

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (1):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP066711.1 - Region 7 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,230,939 - 2,265,383 nt. (total: 34,445 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deaminase
JGZ56_RS10610: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

Lyases: decarboxylase
JGZ56_RS10580: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Ligases: synthase
JGZ56_RS10615: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000943.5 |  | 0.82 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0002471.3 |  | 0.56 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0002469.2 |  | 0.53 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0000947.5 |  | 0.53 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0001572.3 |  | 0.52 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002682.2 |  | 0.52 | other (other) | aerobactin | Vibrio mimicus
BGC0001499.5 |  | 0.50 | other (other) | aerobactin | Pantoea ananatis
BGC0001870.3 |  | 0.50 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001713.5 |  | 0.50 | other (other) | ochrobactin | Ochrobactrum anthropi

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000943.5 |  | 0.82 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.5 |  | 0.59 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0002471.3 |  | 0.56 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0002469.2 |  | 0.53 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0000947.5 |  | 0.53 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0001572.3 |  | 0.52 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002682.2 |  | 0.52 | other (other) | aerobactin | Vibrio mimicus
BGC0001499.5 |  | 0.50 | other (other) | aerobactin | Pantoea ananatis
BGC0001870.3 |  | 0.50 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001713.5 |  | 0.50 | other (other) | ochrobactin | Ochrobactrum anthropi

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.40 out of 27.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.13 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.07 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.84 out of 29.38
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.87 out of 21.55
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.38 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.17 out of 29.38
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.57 out of 24.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
Additional weak hits (5):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.92 out of 31.73
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.74 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.83 out of 30.11
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.09 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.03 out of 32.74
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
FuR variant 1 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_CP066711.1 - Region 8 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,373,619 - 2,395,671 nt. (total: 22,053 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.42 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0001171.5 |  | 0.41 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000564.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001170.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000566.5 |  | 0.39 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001391.3 |  | 0.37 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000552.3 |  | 0.36 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001210.5 |  | 0.36 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.42 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0001171.5 |  | 0.41 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000564.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001170.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000566.5 |  | 0.39 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001391.3 |  | 0.37 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000552.3 |  | 0.36 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001210.5 |  | 0.36 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.42 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.69 out of 26.06
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.45 out of 33.14
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.93 out of 32.93
Confidence: medium
Additional weak hits (3):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 28.31 out of 39.62
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.12 out of 30.98
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.54 out of 35.63
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
TFBS Finder
Azole RiPPs
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 2 | Zinc-responsive repressor

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CP066711.1 - Region 9 - opine-like-metallophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,519,566 - 2,541,682 nt. (total: 22,117 nt) Show pHMM detection rules used
opine-like-metallophore: (CntL and CntM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Translocases: permease
JGZ56_RS11995: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | opine-like-metallophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002487.3 |  | 0.81 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3 |  | 0.79 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002489.2 |  | 0.63 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0002490.2 |  | 0.59 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000504.5 |  | 0.40 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0002656.2 |  | 0.39 | PKS | oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B | Streptacidiphilus oryzae TH49
BGC0000488.4 |  | 0.39 | ribosomal | circularin A | Clostridium beijerinckii
BGC0002115.3 |  | 0.38 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002568.2 |  | 0.38 | other (other) | Ethylenediaminesuccinic acid hydroxyarginine | Streptomyces scabiei 87.22

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002487.3 |  | 0.81 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3 |  | 0.79 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002489.2 |  | 0.63 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0002490.2 |  | 0.59 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000504.5 |  | 0.40 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0002656.2 |  | 0.39 | PKS | oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B | Streptacidiphilus oryzae TH49
BGC0000488.4 |  | 0.39 | ribosomal | circularin A | Clostridium beijerinckii
BGC0002115.3 |  | 0.38 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002568.2 |  | 0.38 | other (other) | Ethylenediaminesuccinic acid hydroxyarginine | Streptomyces scabiei 87.22

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.23 out of 29.38
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.99 out of 27.55
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (3):
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.07 out of 32.93
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.20 out of 25.88
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.17 out of 30.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
ZuR variant 1 | Zinc-responsive repressor