GCF_016455085.1 - 9 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP066713.1 (Staphylococcus pseudintermedius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NI-siderophore	655,657	688,656	High	staphyloferrin A	other:non-nrp siderophore
Region 2	CDPS,cyclic-lactone-autoinducer	810,511	839,641
Region 3	RiPP-like	879,789	890,832
Region 4	terpene-precursor	1,265,868	1,286,749
Region 5	RiPP-like	2,081,195	2,093,060
Region 6	NI-siderophore	2,166,893	2,201,345	High	staphyloferrin B	other:other
Region 7	azole-containing-RiPP	2,313,279	2,335,331
Region 8	sactipeptide	2,407,802	2,429,142	Low	subtilosin A	ribosomal:RiPP:Thiopeptide
Region 9	opine-like-metallophore	2,461,035	2,483,151	High	staphylopine	other:other

NZ_CP066713.1 - Region 1 - NI-siderophore

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Location: 655,657 - 688,656 nt. (total: 33,000 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

JGZ50_RS02910: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.5	0.79	other (non-nrp siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.3	0.56	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000939.5	0.56	other (other)	aerobactin	Grimontia hollisae
BGC0000947.5	0.54	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0002682.2	0.53	other (other)	aerobactin	Vibrio mimicus
BGC0002073.3	0.52	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002683.2	0.49	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0000943.5	0.47	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001948.3	0.43	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0002681.3	0.41	other (other)	rhizoferrin	Francisella tularensis subsp. tularensis SCHU S4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.5	0.79	other (non-nrp siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.3	0.56	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000939.5	0.56	other (other)	aerobactin	Grimontia hollisae
BGC0000947.5	0.54	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0002682.2	0.53	other (other)	aerobactin	Vibrio mimicus
BGC0002073.3	0.52	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002683.2	0.49	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0000943.5	0.47	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001948.3	0.43	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0002681.3	0.41	other (other)	rhizoferrin	Francisella tularensis subsp. tularensis SCHU S4

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.07 out of 26.06

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.84 out of 29.38

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.17 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.41 out of 29.38

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 27.02 out of 32.74

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.40 out of 21.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.29 out of 24.78

Confidence: medium

Additional weak hits (1):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.03 out of 32.74

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
FuR variant 2	Ferric Uptake Regulator
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP066713.1 - Region 2 - CDPS,cyclic-lactone-autoinducer

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Location: 810,511 - 839,641 nt. (total: 29,131 nt) Show pHMM detection rules used

CDPS: CDPS
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

JGZ50_RS03670: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: kinase

JGZ50_RS03690: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Hydrolases: protease

JGZ50_RS03755: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase

JGZ50_RS03720: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002103.2	0.63	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0002667.2	0.29	ribosomal	estericin A	Clostridium estertheticum
BGC0001291.3	0.28	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0000540.5	0.26	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0002579.2	0.23	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.21	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000193.3	0.20	PKS	aclacinomycin	Streptomyces galilaeus
BGC0000346.5	0.19	NRPS, PKS	epoxomicin	Goodfellowiella coeruleoviolacea
BGC0000876.5	0.19	other (other)	neopolyoxin C	Streptomyces tendae
BGC0000651.5	0.17	terpene	KS-505a	Streptomyces argenteolus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002103.2	0.69	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0002667.2	0.47	ribosomal	estericin A	Clostridium estertheticum
BGC0001291.3	0.45	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0000540.5	0.43	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0001171.5	0.41	ribosomal	listeriolysin S	Listeria monocytogenes serotype 4b str. F2365
BGC0002579.2	0.39	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0001687.3	0.39	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0000521.3	0.38	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000624.3	0.38	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002663.2	0.38	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.70 out of 20.97

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.15 out of 18.16

Confidence: strong

Additional weak hits (2):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.06 out of 31.73

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.13 out of 29.72

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A

NZ_CP066713.1 - Region 3 - RiPP-like

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Location: 879,789 - 890,832 nt. (total: 11,044 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.39	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0000497.3	0.36	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0001929.2	0.36	ribosomal	WGK	Streptococcus ferus
BGC0002583.2	0.36	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0002713.2	0.24	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000019.5	0.24	PKS	angolamycin	Streptomyces eurythermus
BGC0002122.2	0.23	NRPS	gramicidin S	Aneurinibacillus migulanus
BGC0001214.5	0.21	NRPS	marformycin A, marformycin B, marformycin C, marformycin D, marformycin E, marformycin F	Streptomyces drozdowiczii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.39	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0000497.3	0.36	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0001929.2	0.36	ribosomal	WGK	Streptococcus ferus
BGC0002583.2	0.36	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0002713.2	0.24	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000019.5	0.24	PKS	angolamycin	Streptomyces eurythermus
BGC0002122.2	0.23	NRPS	gramicidin S	Aneurinibacillus migulanus
BGC0001214.5	0.21	NRPS	marformycin A, marformycin B, marformycin C, marformycin D, marformycin E, marformycin F	Streptomyces drozdowiczii

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.38 out of 27.78

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.25 out of 20.97

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.36 out of 29.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.13 out of 27.78

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 26.19 out of 30.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.65 out of 28.19

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.21 out of 32.93

Confidence: medium

Additional weak hits (1):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.45 out of 30.97

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
LexA variant 3	Repressor of DNA damage response
SypG	Regulator of biofilm formation and host colonization
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP066713.1 - Region 4 - terpene-precursor

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Location: 1,265,868 - 1,286,749 nt. (total: 20,882 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

JGZ50_RS06100: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: carboxylase

JGZ50_RS06045: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase

JGZ50_RS06030: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthase synthetase

JGZ50_RS06070: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

JGZ50_RS06075: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000234.5	0.42	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002591.2	0.41	PKS, terpene	aurachin C, aurachin D, aurachin SS	Streptomyces sp.
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001605.3	0.40	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000905.5	0.40	other (other)	heme D1	Heliobacillus mobilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000234.5	0.42	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002591.2	0.41	PKS, terpene	aurachin C, aurachin D, aurachin SS	Streptomyces sp.
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001605.3	0.40	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000905.5	0.40	other (other)	heme D1	Heliobacillus mobilis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

JGZ50_RS06070: PT_FPPS_like

Domain 1 (29 - 292): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.46 out of 24.78

Confidence: strong

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.58 out of 23.05

Confidence: strong

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
LexA variant 2	Repressor of DNA damage response
PerR	Peroxide regulator

NZ_CP066713.1 - Region 5 - RiPP-like

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Location: 2,081,195 - 2,093,060 nt. (total: 11,866 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002674.2	0.51	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001864.3	0.48	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540
BGC0001862.4	0.48	ribosomal	pallidocin	Aeribacillus pallidus
BGC0001863.4	0.47	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0001861.4	0.46	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0001555.4	0.46	ribosomal	colicin V	Escherichia coli chi7122
BGC0000617.5	0.46	ribosomal	coagulin	Bacillus coagulans
BGC0002586.2	0.46	ribosomal	ASM1	Lactiplantibacillus plantarum
BGC0000484.5	0.46	ribosomal	glycocin F	Lactobacillus plantarum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002674.2	0.51	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001864.3	0.48	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540
BGC0001862.4	0.48	ribosomal	pallidocin	Aeribacillus pallidus
BGC0001863.4	0.47	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0001861.4	0.46	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0001555.4	0.46	ribosomal	colicin V	Escherichia coli chi7122
BGC0000617.5	0.46	ribosomal	coagulin	Bacillus coagulans
BGC0002586.2	0.46	ribosomal	ASM1	Lactiplantibacillus plantarum
BGC0000484.5	0.46	ribosomal	glycocin F	Lactobacillus plantarum

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.85 out of 25.31

Confidence: strong

Additional weak hits (2):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.05 out of 30.97

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor

NZ_CP066713.1 - Region 6 - NI-siderophore

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Location: 2,166,893 - 2,201,345 nt. (total: 34,453 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase

JGZ50_RS10425: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

Hydrolases: deaminase

JGZ50_RS10470: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Ligases: synthase

JGZ50_RS10475: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000943.5	0.77	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.3	0.57	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0002471.3	0.56	other (other)	baumannoferrin A, baumannoferrin B	Acinetobacter baumannii AYE
BGC0002469.2	0.53	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001572.3	0.52	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0001499.5	0.50	other (other)	aerobactin	Pantoea ananatis
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0001713.5	0.50	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0000939.5	0.50	other (other)	aerobactin	Grimontia hollisae
BGC0002682.2	0.50	other (other)	aerobactin	Vibrio mimicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000943.5	0.77	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.3	0.57	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0002471.3	0.56	other (other)	baumannoferrin A, baumannoferrin B	Acinetobacter baumannii AYE
BGC0002469.2	0.53	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001572.3	0.52	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0001499.5	0.50	other (other)	aerobactin	Pantoea ananatis
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0001713.5	0.50	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0000939.5	0.50	other (other)	aerobactin	Grimontia hollisae
BGC0002682.2	0.50	other (other)	aerobactin	Vibrio mimicus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.40 out of 27.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.13 out of 26.06

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.07 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.84 out of 29.38

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.87 out of 21.55

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.38 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.17 out of 29.38

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.57 out of 24.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

Additional weak hits (5):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.92 out of 31.73

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.74 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.83 out of 30.11

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.09 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.03 out of 32.74

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
FuR variant 1	Ferric Uptake Regulator
GnfM	Regulator of nitrogen-fixation genes
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP066713.1 - Region 7 - azole-containing-RiPP

Download region GenBank file

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Location: 2,313,279 - 2,335,331 nt. (total: 22,053 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.42	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001171.5	0.41	ribosomal	listeriolysin S	Listeria monocytogenes serotype 4b str. F2365
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000564.5	0.40	ribosomal	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0001170.5	0.40	ribosomal	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0000566.5	0.39	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS
BGC0001887.3	0.39	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001391.3	0.37	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000552.3	0.36	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001210.5	0.36	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.42	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001171.5	0.41	ribosomal	listeriolysin S	Listeria monocytogenes serotype 4b str. F2365
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000564.5	0.40	ribosomal	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0001170.5	0.40	ribosomal	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0000566.5	0.39	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS
BGC0001887.3	0.39	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001391.3	0.37	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000552.3	0.36	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001210.5	0.36	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.42 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.69 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.45 out of 33.14

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.93 out of 32.93

Confidence: medium

Additional weak hits (3):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 28.31 out of 39.62

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.12 out of 30.98

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.54 out of 35.63

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 2	Zinc-responsive repressor

Core peptide predictions

No core peptides found.

NZ_CP066713.1 - Region 8 - sactipeptide

Download region GenBank file

Download region SVG

Location: 2,407,802 - 2,429,142 nt. (total: 21,341 nt) Show pHMM detection rules used

sactipeptide: (subtilosin or thuricin or TIGR04404 or Subtilosin_A or skfc)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Sactipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: sulfhydrylase

JGZ50_RS11680: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000602.5	0.55	ribosomal	subtilosin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000600.3	0.45	ribosomal	thurincin H	Bacillus thuringiensis
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001540.5	0.36	other (other)	CC-1065	Streptomyces zelensis
BGC0000783.3	0.35	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0001607.5	0.34	other (other)	gilvusmycin	Streptomyces sp. NRRL B-1347
BGC0000815.4	0.34	other (other)	loline, N-acetylnorloline, N-formylloline	Epichloe uncinata
BGC0001637.3	0.31	NRPS	kleboxymycin	Klebsiella oxytoca
BGC0001170.5	0.31	ribosomal	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0001312.5	0.30	NRPS	viscosin	Pseudomonas fluorescens SBW25

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000602.5	0.55	ribosomal	subtilosin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000600.3	0.45	ribosomal	thurincin H	Bacillus thuringiensis
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001540.5	0.36	other (other)	CC-1065	Streptomyces zelensis
BGC0000783.3	0.35	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0001607.5	0.34	other (other)	gilvusmycin	Streptomyces sp. NRRL B-1347
BGC0000815.4	0.34	other (other)	loline, N-acetylnorloline, N-formylloline	Epichloe uncinata
BGC0001637.3	0.31	NRPS	kleboxymycin	Klebsiella oxytoca
BGC0001170.5	0.31	ribosomal	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0001312.5	0.30	NRPS	viscosin	Pseudomonas fluorescens SBW25

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Sactipeptide predictions

Sactipeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.74 out of 29.51

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.22 out of 30.25

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.06 out of 18.46

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97

Confidence: medium

Additional weak hits (7):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.51 out of 30.25

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 22.46 out of 30.12

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.72 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.25 out of 30.11

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.70 out of 25.75

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.15 out of 31.73

Confidence: weak

RREFinder

Sactipeptides

TFBS Finder

RRE predictions

: RRE type: Subtilosin_rSAM_RRE; Location: 26 - 96; Score: 71.1

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
DosR	Hypoxia stress response regulator
RpoN	Regulator of nitrogen assimilation and virulence

NZ_CP066713.1 - Region 9 - opine-like-metallophore

Download region GenBank file

Download region SVG

Location: 2,461,035 - 2,483,151 nt. (total: 22,117 nt) Show pHMM detection rules used

opine-like-metallophore: (CntL and CntM)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Translocases: permease

JGZ50_RS11895: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002487.3	0.81	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3	0.79	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002489.2	0.63	other (other)	pseudopaline	Pseudomonas aeruginosa PAO1
BGC0002490.2	0.59	other (other)	yersinopine	Yersinia pestis CO92
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000616.4	0.39	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0002656.2	0.39	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0000488.4	0.39	ribosomal	circularin A	Clostridium beijerinckii
BGC0002115.3	0.38	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0002568.2	0.38	other (other)	Ethylenediaminesuccinic acid hydroxyarginine	Streptomyces scabiei 87.22

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002487.3	0.81	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3	0.79	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002489.2	0.63	other (other)	pseudopaline	Pseudomonas aeruginosa PAO1
BGC0002490.2	0.59	other (other)	yersinopine	Yersinia pestis CO92
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000616.4	0.39	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0002656.2	0.39	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0000488.4	0.39	ribosomal	circularin A	Clostridium beijerinckii
BGC0002115.3	0.38	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0002568.2	0.38	other (other)	Ethylenediaminesuccinic acid hydroxyarginine	Streptomyces scabiei 87.22

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.23 out of 29.38

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.99 out of 27.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

Additional weak hits (3):

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.07 out of 32.93

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.20 out of 25.88

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.17 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
GnfM	Regulator of nitrogen-fixation genes
ZuR variant 1	Zinc-responsive repressor