LOCUS       NZ_CP066300            23903 bp    DNA     circular CON 30-JAN-2024
DEFINITION  Lactococcus lactis strain WiKim0098 chromosome.
ACCESSION   NZ_CP066300
VERSION     NZ_CP066300.1
KEYWORDS    RefSeq.
SOURCE      Lactococcus lactis
  ORGANISM  Lactococcus lactis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Lactococcus.
REFERENCE   1  (bases 1 to 2424276)
  AUTHORS   Kim,T.W.
  TITLE     Genomic analysis of Lactococcus lactis WiKim0098
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2424276)
  AUTHORS   Kim,T.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-NOV-2020) Microbiology and Functionality Research
            Group, World Institute of Kimchi, 86, Kimchi-ro, Nam-gu, Gwangju,
            Gwangju, Gwangju 61755, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FLYE v. 2.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 342.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 08:40:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,477
            CDSs (total)                      :: 2,390
            Genes (coding)                    :: 2,331
            CDSs (with protein)               :: 2,331
            Genes (RNA)                       :: 87
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 36 of 59
            Pseudo Genes (incomplete)         :: 22 of 59
            Pseudo Genes (internal stop)      :: 12 of 59
            Pseudo Genes (multiple problems)  :: 10 of 59
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:11:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2286055
            Orig. end                         :: 2309958
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP066300.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23903
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RaS-RiPP"
                     /region_number="6"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     cand_cluster    1..23903
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23903
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13903](-)"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13903)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     misc_feature    16..29
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.74"
                     /tool="antismash"
     gene            complement(44..535)
                     /locus_tag="LacL0098_RS11165"
                     /old_locus_tag="LacL0098_11165"
     CDS             complement(44..535)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017865170.1"
                     /locus_tag="LacL0098_RS11165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11165"
                     /product="hypothetical protein"
                     /protein_id="WP_038602405.1"
                     /transl_table=11
                     /translation="MTYYLEEEGFENLFSEMKPIVMKLMKQIRIRTWKIEDYLQEGMII
                     LHLLLEEQSDGQKLHTKFKVKYHQRLIDELRRSYAKKRSHDHFIGLDVYECSDWINSGD
                     TSPDNEVVFNHLLAEVYEGLSAHYQDLLLRQMRGEELTRMERYRLREKIKAILFSEDEE
                     "
     misc_feature    588..597
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            complement(794..2524)
                     /gene="ezrA"
                     /locus_tag="LacL0098_RS11170"
                     /old_locus_tag="LacL0098_11170"
     CDS             complement(794..2524)
                     /codon_start=1
                     /gene="ezrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003132670.1"
                     /locus_tag="LacL0098_RS11170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11170"
                     /product="septation ring formation regulator EzrA"
                     /protein_id="WP_021723359.1"
                     /transl_table=11
                     /translation="MSSTVIILIVVLLVILVAFYAFAILMRKKTEDRILALEERKESLF
                     DLPVQEEIDSVKKMHLVGQSQTIFREWNQKWLDLSSNSFADLEEHIFEAEQLNDSFHFF
                     RARESVADSEAQIELMEGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIADNA
                     DLYGTVITELEKHLANIETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQIPS
                     FIKTIEKDVPKRLDELQEASDKFVAEEYILPDNVNIKERMDDLHDHLVESSSLLEQFEL
                     DRVEAELGLIQEKVEELYAIFEREYSARRNVEKRSSVLKEYIEHIRANNKNLLLEIDHV
                     TQAYILSGNEKGYVRGYQEHLESLDSDVDEILGNIQAKTMPYSILSRRVNSVVNALEDI
                     EKNQIKISDTLTGLRDEERAAQEIAERFDSELRTIKRYVEKCNLPGLPKDYLDLFFTTG
                     DRVQNLFKELGRVRINIDTINHLVDVSTEDMHVLKEATTNLTDHAVLAEQLIQYANRYK
                     AANEQVAQGISRALQLFENSRDYDGSFDEISKTLELVEPGAASRISGVYFKNKPTPDYL
                     "
     gene            complement(2729..3757)
                     /gene="tsf"
                     /locus_tag="LacL0098_RS11175"
                     /old_locus_tag="LacL0098_11175"
     CDS             complement(2729..3757)
                     /GO_function="GO:0003746 - translation elongation factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="tsf"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010906339.1"
                     /locus_tag="LacL0098_RS11175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11175"
                     /product="translation elongation factor Ts"
                     /protein_id="WP_010906339.1"
                     /transl_table=11
                     /translation="MAVTAAQVKELREKTGAGIMDAKRALVETDGNMEAAAELLREKGI
                     AKAAKKADRVAAEGLTGIAVNGNVAAIVELNSETDFVAKNDQFVALVKETAELIASKKP
                     ATNEEALALETASGITLEAELVQATATIGEKITFRRFAVIEKTDAQHFGAYQHNGGKIG
                     VVSVVEGADETLAKQVSMHIAAMNPTVLSADELDSEFVKAELAQMNHKIDEDNASRVLV
                     NKPELPHHEFGSKSQLTEEVLAAAKASFEEELKAEGKPEKIWDKILPGKMAKFIVDNTK
                     VDQQFALLAQLYIMDDSKTVEAFLESKGAKAIAFTRFEVGEGIEKAETDFAAEVEAAKA
                     GL"
     misc_feature    complement(3803..3816)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.97"
                     /tool="antismash"
     gene            complement(3879..4646)
                     /gene="rpsB"
                     /locus_tag="LacL0098_RS11180"
                     /old_locus_tag="LacL0098_11180"
     CDS             complement(3879..4646)
                     /GO_component="GO:0000314 - organellar small ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010906340.1"
                     /locus_tag="LacL0098_RS11180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11180"
                     /product="30S ribosomal protein S2"
                     /protein_id="WP_038602408.1"
                     /transl_table=11
                     /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKPYIFTERNGIHVIDLQK
                     TVKLVDDAYNYVKNASQEGAVVLFVGTKKQAAEAVKEEALRAGQYYVNHRWLGGMLTNW
                     NTIQTRVTRLKEINKMEEEGTFEVLPKKEVVLLNKERERLEKFIGGIADMPRIPDVIYI
                     VDPHAEQIAVKEAKTLGIPVVAMVDTNADPEPIDVVIPANDDAIRAVKLITAKMADAII
                     EGRQGEDAAEDFVAEEAASEESLEELAEIVEGK"
     gene            5005..6030
                     /locus_tag="LacL0098_RS11185"
                     /old_locus_tag="LacL0098_11185"
     CDS             5005..6030
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017865172.1"
                     /locus_tag="LacL0098_RS11185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11185"
                     /product="lactonase family protein"
                     /protein_id="WP_038602411.1"
                     /transl_table=11
                     /translation="MKEKILLGGYTKRVSKGVYSVLLDTKAAELSSLNEVAAVQNPTYI
                     TLDEKGHLYTCAADSNGGGIAAFDFDGETATHLGNVTTTGAPLCYVAVDEARQLVYGAN
                     YHLGEVRVYKIQANGSLRLMDTVKHTGSGPRPEQASSHVHYSDLTPDGRLVTCDLGTDE
                     VTVYDVIGEGKLNIATIYRAEKGMGARHITFHPNGKIAYLVGELNSTIEVLSYNEEKGR
                     FARLQTISTLPEGYHGANGVAAIRISSDGKFLYTSNRGHDSLTTYKVSPLGTKLETIGW
                     TNTEGRIPRDFNFNKTENYIIVAHQESDNLSLFLRDKKTGTLTLEQKDFYAPEITCVLP
                     L"
     misc_feature    6073..6091
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.9"
                     /tool="antismash"
     misc_feature    6162..6177
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     misc_feature    complement(6229..6244)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            6262..8973
                     /gene="adhE"
                     /gene_synonym="adhC"
                     /locus_tag="LacL0098_RS11190"
                     /old_locus_tag="LacL0098_11190"
     CDS             6262..8973
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /GO_function="GO:0004022 - alcohol dehydrogenase (NAD+)
                     activity [Evidence IEA]"
                     /GO_function="GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006066 - alcohol metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0015976 - carbon utilization [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="adhE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="adhC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003132664.1"
                     /locus_tag="LacL0098_RS11190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11190"
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="WP_200984786.1"
                     /sec_met_domain="Aldedh (E-value: 5.6e-18, bitscore: 61.8,
                     seeds: 89, tool: rule-based-clusters)"
                     /sec_met_domain="Fe-ADH (E-value: 1.1e-106, bitscore:
                     353.8, seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKKAAPAAKKVLSAEEKAAKFQEAVAYTDKLVKKAQAAVLKFE
                     GYTQTQVDTIVAAMALAASKHSLELAHEAVNETGRGVVEDKDTKNHFASESVYNAIKND
                     KTVGVISENKVAGSVEIASPLGVLAGIVPTTNPTSTAIFKSLLTAKTRNAIVFAFHPQA
                     QKCSSHAAKIVYDAAIEAGAPEDFIQWIEVPSLDMTTALIQNRGLATILATGGPGMVNA
                     ALKSGNPSLGVGAGNGAVYVDATANIERAVEDLLLSKRFDNGMICATENSAVIDASVYD
                     EFIAKMQEQGAYMVPKKDYKAIESFVFVERAGEGFGVTGPVAGRSGQWIAEQAGVKVPK
                     DKDVLLFELDKKNIGEALSSEKLSPLLSIYKAETREEGIEIVRSLLAYQGAGHNAAIQI
                     GAMDDPFVKEYGEKVEASRILVNQPDSIGGVGDIYTDAMRPSLTLGTGSWGKNSLSHNL
                     STYDLLNVKTVAKRRNRPQWVRLPKEIYYEKNAISYLQELPHVHKAFIVADPGMVKFGF
                     VDKVLEQLAIRPTQVETSIYGSVQPDPTLSEAIAIARQMKQFEPDTVICLGGGSALDAG
                     KIGRLIYEYDARGEADLSDDASLKELFQELAQKFVDIRKRIIKFYHPHKAQMVAIPTTS
                     GTGSEVTPFAVITDDETHVKYPLADYQLTPQVAIVDPEFVMTVPKRTVSWSGIDAMSHA
                     LESYVSVMSSDYTKPISLQAIKLIFENLTESYHYDPAHPTKEGQKARENMHNAATLAGM
                     AFANAFLGINHSLAHKIGGEFGLPHGLAIAIAMPHVIKFNAVTGNVKRTPYPRYETYRA
                     QKDYAEISRFMGFAGKDDSDEKAVQALVAELKKLTDSIDINITLSGNGVDKAHLERELD
                     KLADLVYDDQCTPANPRQPRIDEIKQLLLDQY"
     gene            complement(9311..9808)
                     /locus_tag="LacL0098_RS11195"
                     /old_locus_tag="LacL0098_11195"
     CDS             complement(9311..9808)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898640.1"
                     /locus_tag="LacL0098_RS11195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11195"
                     /product="nitroreductase family protein"
                     /protein_id="WP_038602414.1"
                     /sec_met_domain="PF00881 (E-value: 1.9e-08, bitscore: 31.6,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLEELIQLRKSNKFHNIGVNVESVIEVVKKSYYNFEKHSVPSA
                     GAIYGLKVLLFYKNNKKIFNSKGEISTEKFEINQIKKTCFYDDKYFSSSSILIAVTYDY
                     DKYFGKYGNCGIRYASIECGAFLQNFQLLLSEKEIYGCPLGFVDNDALLGIEEPLIYFI
                     IN"
     gene            complement(9795..10004)
                     /locus_tag="LacL0098_RS11200"
                     /old_locus_tag="LacL0098_11200"
     CDS             complement(9795..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011677212.1"
                     /locus_tag="LacL0098_RS11200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11200"
                     /product="hypothetical protein"
                     /protein_id="WP_003132661.1"
                     /transl_table=11
                     /translation="MKYKLNPLFTLRKTDKAVFNFSRAELTQFNDTGFDILLAVLEQES
                     DREWTDDEDEFLKELIKEKIVEES"
     gene            complement(10001..10828)
                     /locus_tag="LacL0098_RS11205"
                     /old_locus_tag="LacL0098_11205"
     CDS             complement(10001..10828)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015427187.1"
                     /locus_tag="LacL0098_RS11205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11205"
                     /product="radical SAM protein"
                     /protein_id="WP_026138971.1"
                     /sec_met_domain="Fer4_12 (E-value: 1.8e-10, bitscore: 38.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.5e-16, bitscore: 57.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 7.2e-08, bitscore: 29.2,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRDDELFLPIKVYIYLTNHCHYECDYCFLKEMKMLNTKEISKED
                     LEKIAYYLEKYKVPLVAICGGDPILHPKLIDFVQLLSEHKNYPTIATNAVDVSYEYLYQ
                     LKSAGIRYLQIGIDSLRYSKLDNYKENGHLRKVEKTVKYLKELGILYGFATCVTRKNIG
                     ELSKIASYAKETGAELLKLSTYDGENQVYKLTEIQKEELKIFVRQYNTDGIYVRYSPVQ
                     ETLNYVSEYPSLTIYANGDLAIEETGDVIGNISTSEPAVEYKKYILEKWRTNK"
     gene            complement(10821..12020)
                     /locus_tag="LacL0098_RS12475"
     CDS             complement(10821..12020)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LacL0098_RS12475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_229049654.1"
                     /transl_table=11
                     /translation="MTQFFNGQKILFINRILFDDAFITVVEVIFFSVYLKLSFSDFSSI
                     MGLCLLISLLVQIPTGYLSDKFDRKLMLVLGNGAEIVCLITLLFLPSLIKGSLFIPVLI
                     IEIIRTGMLALASGNFEVLIFNMFKREGKTEKDFMEKSASYFSIGAIIAAISGFVSTVL
                     FSYLVILPLILDLSIKIIKLLSAIFMCSEAIHKEMTKIKMKVKSLNHKLLFLLFSLALL
                     FCISRGTFSLYQPVMTSLGIPLYYYGLLIMIVNLSIFVLLRVLKKKVSLFKLSTLLLVS
                     FAVLTFQGVLVIEHFIPGNLFRFLIVAIIFSSMQIIRLFSEGLSSYFINTAIKDRDDKT
                     TIFSLYSTMAQLLLSASFFLMGVVQGGVDNYLMTYLYISAIFVLIIMALVIFGKGKKYV
                     "
     gene            complement(12017..12943)
                     /locus_tag="LacL0098_RS12480"
     CDS             complement(12017..12943)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="LacL0098_RS12480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="radical SAM protein"
                     /protein_id="WP_236253314.1"
                     /sec_met_domain="PTHR43273 (E-value: 1.6e-35, bitscore:
                     119.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.7e-08, bitscore: 32.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1e-20, bitscore: 71.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 6.3e-06, bitscore: 22.9,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINYLKNPLFLTWMLTNKCNLRCKFCYLEDYQGKELELDEINQVL
                     DIIQDKEFTHVSLLGGEPTECEYFEYIIIQLEKLRISYSFSTNGQKLFRNEELIRILSK
                     SKYLKEVQISLESPQKLINDAVRGKGTFESAIKSVALLVKENVPTRLAMVVTKENNSTI
                     QQMIDMCATLGCRELRLMPFMPMGTGLLEKERLFMDYEGLVRACSDLKIPDNLIVTTYL
                     KEENTAETLGCGAGTAACVINSDLTLSDCPVVSQTQKSIEKLGNDGSSFDYIWGTSSIF
                     NIWRAGKYRKSTSCNLCPLFEECGGYQ"
     gene            complement(13046..13903)
                     /locus_tag="LacL0098_RS11215"
                     /old_locus_tag="LacL0098_11215"
     CDS             complement(13046..13903)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017865177.1"
                     /locus_tag="LacL0098_RS11215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11215"
                     /product="transcriptional regulator"
                     /protein_id="WP_104143776.1"
                     /sec_met_domain="TIGR01716 (E-value: 4.5e-30, bitscore:
                     102.0, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKNLKTGKIIAFIKETKHLKLKEMTGGSFSESQLAKFEKGETEI
                     TVGKLFTVLENSNVYLDEFQNLYNDYEQSDEYTFRHKLAVAYAQKNIEKIIEIHNFWKE
                     KSQQNPENKYYKINETVVKTNLVMVQNAEDIKKDTDLLMNYLESVSEWGRYELWVFGNC
                     LRHFDDNALKYYGMQILGKSNYYHSIHLNQQIVIRTFLNLIDTWLRRENLMQAFKYINH
                     LKEIGIGINFFYEKILFEYHKAHYKVLQKQNGAIEEMKKHAQTLADYGFPLEAKVLFEE
                     IEKL"
     gene            complement(14024..15052)
                     /locus_tag="LacL0098_RS11220"
                     /old_locus_tag="LacL0098_11220"
     CDS             complement(14024..15052)
                     /EC_number="3.4.21.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015427190.1"
                     /locus_tag="LacL0098_RS11220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11220"
                     /product="SepM family pheromone-processing serine protease"
                     /protein_id="WP_058206118.1"
                     /transl_table=11
                     /translation="MKKNKKINPKLKWGISIGLIVVALLALFYPTSYYVEMPGTTEPLG
                     KMVKVEGKKDEHKGDFFLTTVQIARANLATMIYSHFNSFTSIYSEQEMTGGLNDAQFNR
                     VNQFYMETAQNTAIYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELADTITAVNGQ
                     QFTSSADMIAYVSKQKVGDSVTIEYTRIDGTKHKSTGKYIKIANGKTGIGISLVDHTEV
                     VTNPKVTVNAGSIGGPSAGMMFTLEIYSQLTGKDLRNGREIAGTGTIEHDGSIGQIGGV
                     DKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAKKLKTKMKIVPVKTIQDALDYL
                     EK"
     gene            complement(15039..15536)
                     /gene="coaD"
                     /locus_tag="LacL0098_RS11225"
                     /old_locus_tag="LacL0098_11225"
     CDS             complement(15039..15536)
                     /EC_number="2.7.7.3"
                     /GO_function="GO:0004595 - pantetheine-phosphate
                     adenylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="coaD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010906348.1"
                     /locus_tag="LacL0098_RS11225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11225"
                     /product="pantetheine-phosphate adenylyltransferase"
                     /protein_id="WP_058206117.1"
                     /sec_met_domain="CTP_transf_like (E-value: 1.7e-19,
                     bitscore: 67.5, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKIGLFTGTFDPLTNGHLDVIKRASQHFDQLYVGIFKNDQKNP
                     LFPTDKRVEMLEEALTSLSVTHKVKVIKHERDLTVNIAKKLGVTALVRSLRNSQDLEYE
                     KNMFYFNMEMTGVETIFFLAKPELEPLNSTRMRELHAFGQDVSAWVPENVSRELRKLDE
                     KK"
     gene            complement(15584..16123)
                     /gene="rsmD"
                     /locus_tag="LacL0098_RS11230"
                     /old_locus_tag="LacL0098_11230"
     CDS             complement(15584..16123)
                     /EC_number="2.1.1.171"
                     /GO_function="GO:0052913 - 16S rRNA
                     (guanine(966)-N(2))-methyltransferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0031167 - rRNA methylation [Evidence IEA]"
                     /codon_start=1
                     /gene="rsmD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015427191.1"
                     /locus_tag="LacL0098_RS11230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11230"
                     /product="16S rRNA (guanine(966)-N(2))-methyltransferase
                     RsmD"
                     /protein_id="WP_181022894.1"
                     /transl_table=11
                     /translation="MRVVSGNYGGRPLKTLAGKTTRPTTDKVKGAIFNMIGPYFEGGRV
                     LDLFAGSGSLAIEAISRGMDHAILVEKDRAAQQVILENIKMTKEPEKFQLLKMSAERVL
                     SNLSETFDLVLLDPPYAKEQIVENLELLQEKKRLTENVIVVCETDKEVELPNQIGKLEL
                     TRQKTYGISKISIYEF"
     misc_feature    complement(16123..16136)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 24.19"
                     /tool="antismash"
     gene            complement(16292..17512)
                     /locus_tag="LacL0098_RS11235"
                     /old_locus_tag="LacL0098_11235"
     CDS             complement(16292..17512)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015427192.1"
                     /locus_tag="LacL0098_RS11235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11235"
                     /product="MFS transporter"
                     /protein_id="WP_104143767.1"
                     /transl_table=11
                     /translation="MKDFFGLHPTLKIRLIMNFFGTLCFSTVGGSMTIYYNKYMGAGIT
                     GLLLVISSVMVFLVGLYAGHLSDVQGRRPVMIFSTAITGFGGALATFANSSFYFNPWVT
                     FLGFLIINFGFGFFNTASQAMIVDLTTSENRRVVYSIQYWIINFAIMIGSGLSGWFFRD
                     YLVWLLLAITIEEIVSCLVVIFWIDESFNPDTQQHKQESNIIKAYFTVAKDRIFMYYLF
                     ASVFIAMIFNQIDYYLPVHLSDSFRTARIFGIEVYGQRMLTIFLMVNTLVIVLFMGKVN
                     KLTKNWSRSSGISIGIILQGLGFMIAFLGRDLTWELVAALVATIGEMILVPFSQALRAD
                     LMDGDQVGTYTGAFSVTQPIASVLSGILVSLSSLYGNIGMTIIMFFIIVLGVLPSLRAI
                     RMHESHS"
     misc_feature    complement(17483..17497)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 16.24"
                     /tool="antismash"
     misc_feature    17529..17542
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.11"
                     /tool="antismash"
     gene            complement(17596..18822)
                     /gene="lmrP"
                     /locus_tag="LacL0098_RS11240"
                     /old_locus_tag="LacL0098_11240"
     CDS             complement(17596..18822)
                     /codon_start=1
                     /gene="lmrP"
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836081.1"
                     /locus_tag="LacL0098_RS11240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11240"
                     /product="multidrug efflux MFS transporter LmrP"
                     /protein_id="WP_104143764.1"
                     /transl_table=11
                     /translation="MKEFWNLDKNLQLRLGIVFLGAFSYGTVFSSMTIYYNQHLGSAIT
                     GILLALSAVATFVAGILAGFFADRNGRKPVMVFGTVIQLLGALLAIGSNLPGHVNPWST
                     FIAFLLISFGYNLVITAGNAMIIDASNAENRKVVFMLDYWAQNLSVILGAALGAWLFRP
                     AFEALLVILLLTVLVSFFLTTFVMTETFRPIVKAKEEAENIFQAYKTVLQDKTYMIFMG
                     ANIATTFIIMQFDNFLPVHLSNSFKTITFFGFEIYGQRMLTIYLILACVLVVLLMTTLN
                     RLTKDWSHQKGFIWGSLFMAIGMIFSFLTTTFTPIFIAGIVYTLGEIVYTPSVQTLGAD
                     LMNPEKIGSYNGVAAIKMPIASILAGLLVSISPMIKATGVSLVLALTEVLAIILVLIAV
                     NRHQKTKIN"
     gene            19010..19504
                     /locus_tag="LacL0098_RS11245"
                     /old_locus_tag="LacL0098_11245"
     CDS             19010..19504
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010906351.1"
                     /locus_tag="LacL0098_RS11245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11245"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_058206114.1"
                     /transl_table=11
                     /translation="MVNLKEYENDVNDYAIEITKYLISRGSQLVDAEDAVQDTLVKILS
                     LDIFIEPDKLRAFMYRTSIRTYINSYNRSKHYQKIIKNLEKELETAAFLVESSPLPKII
                     EQLSPYYKELLNAYYYENCSTKQLAEYFECSLSKIKIDLYRARKKLKKQLEKAGYDQWL
                     L"
     gene            19528..20634
                     /locus_tag="LacL0098_RS11250"
                     /old_locus_tag="LacL0098_11250"
     CDS             19528..20634
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836082.1"
                     /locus_tag="LacL0098_RS11250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11250"
                     /product="anti-sigma factor C-terminal domain-containing
                     protein"
                     /protein_id="WP_058206113.1"
                     /transl_table=11
                     /translation="MRTLLIFPYFVLALTLFFGLIRLFIFAINKTRHKLQTTESISNLN
                     KDFHNFALKTKIKRWGLTTWIALTVFSAFIVVGWRVNSAIMEKNFFKTFDYSTAIFTAS
                     APNVAYNNQIIDDYGVFSSNLHSDTYKDIDGYHVPWESYNFSFNVSNVGGLSLNTLSPS
                     VNSNAYFTQTTNQKIASFFSTNANYKSKDYNGILPTHDADKISQLSNHVAEVAVTFDKA
                     YSYNEIQKMIPENLLINWYWIGYNDSKSLDAAGQTNWFGLMSNSNYAENGNNSQLTGKL
                     DNTTYQDFKKSVAAIAKKNQITINDFSPSKDALKQVKKYPTLKSAKFSGVILTGQTKNF
                     VNFDKNSWVYASNVGLTVELRPDIKPLK"
     gene            complement(20730..22076)
                     /locus_tag="LacL0098_RS11255"
                     /old_locus_tag="LacL0098_11255"
     CDS             complement(20730..22076)
                     /EC_number="5.3.1.9"
                     /GO_function="GO:0004347 - glucose-6-phosphate isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648691.1"
                     /locus_tag="LacL0098_RS11255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11255"
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="WP_010906353.1"
                     /transl_table=11
                     /translation="MAHIKFDYSKLTPFVAENELDEIQWQIDGAAKLLHEGKGAGSDYI
                     GWLDLPEDYDKEEFARIQKAAKKIQSDSEVLIVIGIGGSYLGARAAIDFLSNSFVNLQT
                     AEERKAPRILYAGNSISSSYLADLVDYVADKDFSVNVISKSGTTTEPAIAFRVFEEMLV
                     KKYGREEANKRIYATTDKEKGAVKVNADANNWETFVVPDSVGGRFSVLTAVGLLPIAAS
                     GADITALMEGANAARKEYTSTNVHENDAYAYAALRNILYRKGKFSEILINYEPSLQYFS
                     EWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQWIQEGTRTVFETAIRIEKPRKNINI
                     PELDADLDGLGYLQGKDVDFVNKKAADGVLLAHTDGNVPNMIVTLPEQDEFTLGYAIYF
                     FELAIGVSGYLNGINPFNQPGVEAYKKNMFALLGKPGFEELSKELNDRL"
     gene            22420..22926
                     /locus_tag="LacL0098_RS11260"
                     /old_locus_tag="LacL0098_11260"
     CDS             22420..22926
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015427194.1"
                     /locus_tag="LacL0098_RS11260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11260"
                     /product="YkgJ family cysteine cluster protein"
                     /protein_id="WP_021467077.1"
                     /transl_table=11
                     /translation="MMKYTFEIDLDRYKNLAQQKQKTHKKFLAGLAKKPPKQLDKIVKE
                     VHEEVFLEIDCTKCANCCKTLGPLWTEADIERVAKHLKMKVSDFEAAYLRTDEDGDKVF
                     QTMPCPFLGSDNLCSIYEVRPKACREFPHTDRKKIYQINNLTIKNTLYCPAAYEFVEKL
                     SYRLK"
     gene            complement(22960..23805)
                     /locus_tag="LacL0098_RS11265"
                     /old_locus_tag="LacL0098_11265"
     CDS             complement(22960..23805)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003132644.1"
                     /locus_tag="LacL0098_RS11265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_11265"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_058206112.1"
                     /transl_table=11
                     /translation="MKYLVTGATGGYGTYALGFLKELVPISDIVVLARTEEKAAPLKAA
                     GFDVRLADYSDLTALEQAFTGIDRLLFVSGAPGNRQAEHQNVVDAAKSAGISYIAYTSF
                     PQAERATSDLAADHIYTEKAIEKSGIAHTFLRNNWYFENEMPIIAAALSTGKFVYNAPT
                     GKVGWALKREYAEVGAKALAGADFPEVLELSGKILTYAELAQALKAVSDKEFEVVAADD
                     KAFVSHLVETGLPDFVAELFLGFQKDIEAKDLDVESKDFEKALGHSLTDTKEALKELLA
                     "
ORIGIN
        1 atcaaaaaat tccctatttt taataaaaat agggaactct ccttcattct tcatcttctg
       61 aaaataagat ggcttttatt ttttcacgaa ggcgatatcg ttccatacga gttaattctt
      121 ctcctcgcat ttgtcgaagt agtaagtctt gataatgtgc gctcaaacct tcatatactt
      181 ctgccagcaa atgattgaag accacttcat tatctggact agtatcacct gaatttatcc
      241 agtctgagca ttcataaaca tctaaaccta taaaatggtc atggcttcgt ttctttgcat
      301 aactccgtct tagctcatca attaatcttt gatgatactt taccttaaat tttgtatgca
      361 gcttttgacc atcgctctgc tcttctaata gaagatgtaa aataatcatc ccctcttgaa
      421 gataatcctc tattttccat gttctaatac gaatttgttt cattaatttc ataactatag
      481 gtttcatttc tgaaaacaga ttttcaaaac cctcttcttc caagtaatat gtcattggaa
      541 agttctcctt ttatattatc tttatttgat taattagtaa gatgatagaa ggcggcgagt
      601 gtatgtctaa taaacagtca gggagcatct tattataatg agctattttc atatctatcc
      661 tttcaagaca tttttatggc ttttatttca ttataataat ttttaagtgt tttacctaac
      721 gatattatgc gaatattcag aatttataaa ccaataaata aaagcaaggc tattaacctt
      781 gcttttactt attttataag taatcaggag taggtttatt tttaaaataa actcctgaaa
      841 ttctagaagc tgcacctggt tctacaagtt ctagcgtttt tgaaatttca tcaaatgaac
      901 catcatagtc acggctgttt tcaaataatt gaagcgctct tgagatccct tgtgctactt
      961 gttcatttgc agctttataa cgattagcat attgaatcaa ttgttcagct aatactgcat
     1021 ggtcagtcaa attagtcgtt gcttctttta aaacgtgcat atcttcagtg cttacgtcaa
     1081 caagatgatt aattgtatca atgttgattc taactcgtcc taattctttg aaaagatttt
     1141 gtactcgatc tcctgttgtg aagaacaagt cgaggtaatc tttaggaaga ccagggagat
     1201 tacatttttc aacataacgt tttattgtac ggagttcaga atcaaagcgt tccgcaattt
     1261 cttgagctgc tctttcttca tctctgagtc ctgtgagggt atcactaatc ttaatttggt
     1321 tcttctcaat atcttcaagg gcattgacta ctgaatttac tctacgtgaa agaattgagt
     1381 aaggcattgt tttagcttga atatttccta gaatttcatc aacatctgag tcaagagatt
     1441 ctaaatgttc ttgataacct ctaacatatc ctttttcgtt tccagaaagg atataggctt
     1501 gtgtaacatg gtcaatttca aggagaagat ttttattatt tgctctgata tgttcaatat
     1561 attctttgag aactgatgaa cgtttttcaa catttcgacg tgcgctatat tctctttcaa
     1621 aaatagcata aagttcttca actttttctt gaattaaacc aagttcagct tctactcgat
     1681 ctagttcaaa ttgttctaat aatgaactac tttcaacgag atgatcatgt aaatcatcca
     1741 ttctttcttt aatgttgaca ttatcaggaa gaatgtactc ttctgcaacg aatttatcac
     1801 tcgcttcttg taattcgtca agtcgtttag gaacatcttt ttcaattgtt ttaataaatg
     1861 atggaatttg ctctgtaatt gcacgtaaag caatcgtatg ttcttcagca gtctccaaaa
     1921 cttcagccgc ttcaatcgga tctcccgttg agtttagcgt tacaaactga gaaaattctg
     1981 tttcgatatt ggctaaatgt ttttcaagtt cagtaataac cgttccatac aaatctgcat
     2041 tgtcagcaat atcgctacgt aagttatcat ataaatcaag ggattcttga attttatttg
     2101 aattacgctt ttcttgttca acaagttgag caacaccttg acgaattcct tcgacatcac
     2161 cttccattaa ttcaatttgt gcctcactat ccgctacaga ttcacgagca cggaaaaaat
     2221 ggaatgaatc gtttaattgt tcagcttcaa aaatatgttc ttccaaatca gcaaaagaat
     2281 ttgatgataa gtcaagccat ttttggttcc attcacggaa aatcgtttgc gattgtccga
     2341 caagatgcat ttttttaaca gaatcaattt cttcttgaac aggcaaatcg aaaagcgatt
     2401 cctttcgctc ttctaaggct agtatacggt cttctgtttt ctttcgcatt aatattgcaa
     2461 aagcataaaa ggctacgaga ataactaata agacaacaat gaggataatg acagtacttg
     2521 acatgcttta ctccataaaa tgatttaatt acttaaaaat agtttaatta cttaggttag
     2581 atagatttta aatagataga aaatctcaaa tataattata gcatattgcg tcaaagaaat
     2641 acactatttt cttagttttc taaccgaaaa gccgtttttt attttcaaaa taaaaaaagc
     2701 aacctccaga ggctgctttt taattaaatt aaaggcctgc ttttgccgct tcaacttctg
     2761 ctgcaaagtc tgtttcagct ttttcaattc cttcaccaac ttcaaaacgt gtgaatgcaa
     2821 ttgctttagc tccttttgat tcaaggaaag cttcgactgt tttgctgtca tccatgatgt
     2881 aaagttgtgc aagaagagca aattgttggt caacttttgt attgtcaacg atgaatttag
     2941 ccattttacc tggaagaatt ttgtcccaga ttttttctgg ttttccttca gctttaagtt
     3001 cttcttcaaa tgaagctttc gctgctgcaa gaacttcttc tgtcaattgg ctcttagaac
     3061 caaattcatg gtgtggaagt tctggtttgt taacaagtac acggctagcg ttgtcttcat
     3121 caatcttgtg gttcatttgt gctaattcag ctttaacaaa ttctgaatca agttcatcag
     3181 ctgaaagaac agtagggttc attgcagcga tatgcattga tacttgttta gcaagtgttt
     3241 catctgcacc ttcaacgaca gaaacaaccc caattttacc accgttatgt tggtaagctc
     3301 caaagtgttg agcatcagtt ttttcaatta ctgcaaaacg acggaaagtg attttttctc
     3361 cgattgtagc agtcgcttga acaagttctg cttcaagagt aatccctgaa gctgtttcaa
     3421 gtgccaatgc ttcttcgtta gttgctggtt ttttagacgc aataagttct gctgtttctt
     3481 taaccaaggc aacaaattga tcatttttag ctacgaagtc tgtttctgag ttcaattcaa
     3541 caatcgctgc aacatttccg tttacggcaa ttcctgtaag tccttcagcg gctacacgat
     3601 cagctttttt agctgctttc gcaatccctt tttcacgaag aagttctgct gctgcttcca
     3661 tatttccgtc agtttcaaca agagcgcgtt tagcgtccat gattcctgca ccagtttttt
     3721 cacgtaattc ttttacttga gctgctgtta ctgccatttt gtaaatctcc tatgtgtttt
     3781 tttctgtcag tattgacagt agttttattt aaaaaaacag gtgaggcgta aggcctcgcc
     3841 tgttgtagtt acttaattag tataagttga agttaaaatt atttaccttc aacgatttca
     3901 gcaagttctt caagtgattc ttctgaagct gcttcttctg ctacgaaatc ttccgctgca
     3961 tcttcacctt gacgtccttc aatgatagcg tctgccattt tagctgtaat caatttaaca
     4021 gcacggatag catcatcatt tgcagggata actacgtcga ttggttctgg atctgcgttt
     4081 gtgtcaacca ttgctacaac tgggattccc aaagttttag cttctttaac tgcgatttgt
     4141 tcagcatgtg ggtcaacgat gtagataaca tctggaatac gaggcatatc agcgatacca
     4201 ccgatgaatt tttcaaggcg ttcgcgttct ttgttaagaa gaactacttc tttcttaggt
     4261 aaaacttcga aagttccttc ttcttccatt ttgttgattt ctttaaggcg tgtcacacgt
     4321 gtttggatag tgttccagtt agtgagcata ccacccaacc aacggtggtt tacgtagtat
     4381 tgaccagcgc ggagagcttc ttctttaact gcttctgcag cttgtttttt agtaccaaca
     4441 aaaagaacta ctgcaccttc ttgtgaagcg ttttttacat agttgtaagc atcgtcaaca
     4501 agttttacag ttttttgaag gtcgataacg tggataccat tacgttctgt gaagatgtat
     4561 ggtttcattt tcgggttcca acgacgagtt tggtgaccga agtgaacacc agcttcaaga
     4621 agttgtttca ttgaaataac tgacatgtta atgtctcctt ttaaaatagt ttttcctctt
     4681 tcatctgtca tccgcagccg caatacttgc gtacactacg actttgtcga gacgaaatgc
     4741 gagatggttg catagcaact ctatcattat acattgtttg acctattttt gcaagtatct
     4801 attcatgctt ctattgttca gtaaatctat ttttctagcc actcctattg tctgacaaat
     4861 ctaattgtta atttagactc tataatcact aaaagagtaa gttttcaaac ttttttctaa
     4921 gaaaaaaatt aatatttttg ctgaaaccgc tttttttgtg ataaaataat tatagtaaat
     4981 aaattagttt gtgaggagag aaatatgaaa gaaaaaatcc ttttaggcgg ctatacaaaa
     5041 cgtgtatcta aaggcgttta tagtgttctt ttggacacta aagctgctga attatcatca
     5101 ttaaatgaag tcgctgcggt tcaaaacccc acttatatca ctctcgatga aaagggacat
     5161 ctctatactt gcgcagcaga tagtaatggt ggaggaatcg ccgcctttga ttttgatggc
     5221 gaaactgcca ctcatctcgg aaatgtcaca accacgggag ctccactctg ctatgttgcc
     5281 gtggacgaag cgcgccaatt agtttacgga gcgaactatc atcttggaga agttcgtgtt
     5341 tataagattc aagctaatgg ctcactccga ttaatggata cagttaaaca tactggttct
     5401 ggaccacgtc ctgaacaagc tagctcacac gttcattatt ctgatttaac tcctgacgga
     5461 cgccttgtca cctgtgattt gggaacagat gaggtcactg tttatgatgt cattggtgaa
     5521 ggtaagctca atatcgctac aatttatcgt gcagaaaaag gaatgggtgc tcgtcatatt
     5581 actttccatc caaatggtaa aatcgcttat ttagttggag agttaaattc aacaatcgaa
     5641 gttttaagtt ataatgaaga aaaaggacgt tttgctcgtc ttcaaacaat tagcacccta
     5701 cctgaaggtt atcatggagc aaatggtgtt gctgccatcc gtatttcatc tgacggtaaa
     5761 ttcctctata cttctaatcg cggacatgat tctttgacaa cttacaaagt aagtcctctc
     5821 ggtacaaaac ttgaaacgat tggctggaca aatactgaag gtcgtatccc tcgtgatttt
     5881 aatttcaaca aaactgaaaa ttatatcatt gtcgctcatc aagaatctga taatctatct
     5941 cttttcttac gagataaaaa aaccggtact ttaactttgg aacaaaaaga tttttacgct
     6001 cctgaaatca cttgcgtttt accactataa aaatttattt tttcacaaag ttcgactgat
     6061 aaactagaaa agattgctaa ttcctctcaa agaattggca atcttttttt cttcaataaa
     6121 gcttgttata aaccgttttc taaactttcg atgagcattt ttgtaaaaat tatcacaata
     6181 tcgcttgaca tctataaaaa actttgttaa actattcacg taaaagaaag tgaatgaaat
     6241 cacaaaggag aacctacaaa tatggcaact aaaaaagccg ctccagctgc aaagaaagtg
     6301 ttaagcgctg aagaaaaagc cgcaaaattc caagaagctg ttgcttatac tgacaaatta
     6361 gtcaaaaaag cacaagctgc tgttcttaaa tttgaaggat atacacaaac tcaagtcgat
     6421 actattgtcg ctgcaatggc tcttgcagca agcaaacatt ctctagaact cgctcatgaa
     6481 gccgttaatg aaactggtcg tggtgttgtc gaagacaaag ataccaaaaa ccactttgct
     6541 tctgaatctg tttataacgc aattaaaaat gacaaaaccg ttggtgtcat ttctgaaaac
     6601 aaggtggctg gatctgttga aatcgcaagc cctctcggtg tacttgctgg tatcgttcca
     6661 acaactaatc caacatcaac agcaatcttt aaatctttat tgactgcaaa aacacgtaat
     6721 gctattgttt tcgctttcca cccacaagct caaaaatgtt caagccatgc agcaaaaatt
     6781 gtttacgatg ctgcaattga agctggtgca ccggaagact tcattcaatg gattgaagta
     6841 ccaagccttg acatgactac cgccttgatt caaaaccgtg gacttgcaac aatccttgca
     6901 actggtggcc caggaatggt aaacgccgca ctcaaatctg gtaacccttc actcggtgtt
     6961 ggagctggta atggtgctgt ttatgtagat gctactgcaa atattgaacg tgccgttgaa
     7021 gaccttttgc tttcaaaacg ttttgataat gggatgattt gtgccactga aaattcagct
     7081 gttattgatg cttcagttta tgatgaattt attgctaaaa tgcaagaaca aggcgcttat
     7141 atggttccta aaaaagacta caaagctatt gaaagtttcg tttttgttga acgtgctggt
     7201 gaaggttttg gagtaactgg tcctgttgcc ggtcgttctg gtcaatggat tgctgaacaa
     7261 gctggtgtca aagttcctaa agataaagat gtccttcttt ttgaacttga taagaaaaat
     7321 attggtgaag cactttcttc tgaaaaactt tctcctttgc tttcaatcta caaagctgaa
     7381 acacgtgaag aaggaattga gattgtacgt agcttacttg cttatcaagg cgctggacat
     7441 aatgctgcaa ttcaaatcgg tgcaatggat gatccattcg ttaaagaata tggcgaaaaa
     7501 gttgaagctt ctcgtatcct cgttaaccaa ccagattcta ttggtggggt cggagatatc
     7561 tatactgatg caatgcgtcc atcacttaca cttggaactg gttcatgggg gaaaaattca
     7621 ctttcacaca atttgagtac atacgatcta ttgaatgtta aaacagtggc taaacgtcgt
     7681 aatcgcccac aatgggttcg tttgccaaaa gaaatttact acgaaaaaaa tgcaatttct
     7741 tacttacaag aattgccaca cgttcacaaa gctttcatcg ttgctgaccc tggtatggtt
     7801 aaatttggtt tcgttgataa agttttggaa caacttgcta tccgcccaac tcaagttgaa
     7861 acaagcattt atggctctgt tcaacctgac ccaactttga gcgaagcaat tgcaatcgct
     7921 cgtcaaatga aacaatttga acctgacact gtcatctgtc ttggtggtgg ttctgctctc
     7981 gatgctggta agattggtcg tttgatttat gaatatgatg ctcgtggtga agctgacctt
     8041 tctgatgatg caagtttgaa agaacttttc caagaattag ctcaaaaatt tgtcgatatt
     8101 cgtaaacgta ttattaaatt ctaccatcca cataaagcac aaatggttgc aattcctact
     8161 acttctggta ctggttctga agtgactcca tttgcagtta tcactgatga tgaaactcat
     8221 gttaagtacc cacttgctga ctaccaatta acaccacaag ttgccattgt tgaccctgag
     8281 tttgttatga ctgtaccaaa acgtactgtt tcttggtctg gtattgatgc gatgtcacac
     8341 gcgcttgaat cttacgtttc tgttatgtct tctgactata caaaaccaat ttcacttcaa
     8401 gcgatcaaac tcatctttga aaacttgact gagtcttatc attatgaccc agcgcatcca
     8461 actaaagaag gacaaaaagc ccgcgaaaac atgcacaatg ctgcaacact cgctggtatg
     8521 gccttcgcta atgctttcct tggaattaac cactcacttg ctcataaaat tggtggtgaa
     8581 tttggacttc ctcatggtct tgccatcgcc attgctatgc cacatgtcat taaatttaac
     8641 gctgtaacag gaaacgttaa acgcacccct tacccacgtt atgaaacata tcgtgctcaa
     8701 aaggactatg ctgaaatttc acgctttatg ggatttgctg gtaaagatga ttcagatgaa
     8761 aaagctgtgc aagctctggt tgctgaactt aaaaaattga ctgatagcat tgatattaat
     8821 atcacccttt caggaaatgg tgtcgataaa gctcaccttg aacgtgaact tgataaattg
     8881 gctgaccttg tttatgatga tcaatgtact cctgctaatc ctcgtcaacc aagaattgat
     8941 gagattaaac agttgttgtt agatcaatac taataatctg ttgataaaaa taataaaaac
     9001 gctctgatga attcgtcaga gcatttttta ttatagctta tacaactatc aaaaggtata
     9061 aatcaatttc gatataggct cttttcactc cattgattta tatttctata aaaatcaata
     9121 attaattagc gatagaagtc gagttcatgc atgctaataa tgaaattgtt ttaaattctg
     9181 gtttttcttt atgttctttg cgaacatctt tcacagtttc tttgttcatg aaaattcctc
     9241 cttattatgg tactattttg agcccaaata gttatataag aatcctaaac ttcggatatc
     9301 ttatcaaaga ttaattaata ataaaataaa ttaggggttc ttctattccc aacagagcat
     9361 cattatctac gaagcctaat ggacaaccgt atatctcttt ttctgaaagt agtagttgaa
     9421 aattttgcag aaaagcacca cattcgattg aagcatacct tatcccacaa ttaccatatt
     9481 taccaaaata tttatcgtaa tcatatgtca cagcaataag aattgaactt gaagaaaaat
     9541 atttatcatc ataaaaacaa gtttttttaa tttgatttat ctcgaatttc tctgtactta
     9601 tctccccttt agagttaaat atttttttat tgttcttata aaaaagtaaa actttcaaac
     9661 catatatagc tccggcagaa ggaacgctat gtttctcaaa attatagtag gattttttta
     9721 ctacttctat tacactttca acatttacac caatattatg aaatttattt gattttctta
     9781 gttgaataag ctcttcaaga ttcttcaaca attttctcct tgattaactc tttcagaaat
     9841 tcatcttcat catctgtcca ctctctatca ctttcttgtt caagaactgc caataaaata
     9901 tcaaaacctg tatcgttgaa ttgtgttaat tccgcccttg agaaattgaa gactgcttta
     9961 tctgtttttc tgagcgtaaa taatgggttt aatttatact tcatttattt gttctccatt
    10021 tttctaatat atatttttta tattctacag ctggttcaga agtggaaata tttccaataa
    10081 catctcctgt ttcttcaatt gctaaatccc cgtttgcata tattgtcagg gagggatatt
    10141 ccgatacata atttaatgtt tcttgaacag gcgagtagcg tacataaatc ccatcagtat
    10201 tatattgtct tacaaagatt tttaactctt ctttttgaat ttctgttaat ttatatactt
    10261 gattttctcc atcataagtt gaaagtttca acagttcggc tcctgtttct ttagcataac
    10321 tcgcaatttt actaagctct ccaatatttt ttcgagtgac acaagttgca aaaccatata
    10381 atatccccaa ttcttttaaa tatttcacag ttttttcaac ttttctaaga tgcccgtttt
    10441 ctttgtaatt atccaatttt gaatatcgca aactatcaat gcctatctgt aaatatcgaa
    10501 ttcctgctga ttttaactga tataaatact cataggatac gtcaactgca ttagtcgcta
    10561 tagttggata attcttatgt tctgatagta attggacaaa atcaataagt tttgggtgga
    10621 gaattggatc tcccccacaa atagcaacta atggtacttt atatttttct aaataataag
    10681 ctattttttc taaatcttct tttgagatct cttttgtatt taacatcttc atttctttaa
    10741 ggaagcagta atcacattcg taatgacaat gattagttaa atatatatac accttaattg
    10801 gtaaaaaaag ttcgtcatct ctaaacatat tttttcccct ttccaaagat aactaaagcc
    10861 ataataatta ggacaaaaat tgcactaata tataaatagg tcatcaaata gttatcaact
    10921 cccccttgaa caacacccat caggaagaaa gaagcagata gtaaaagctg ggccattgta
    10981 gaataaagag aaaaaatagt tgttttatcg tctctatcct taatcgcggt gttgataaaa
    11041 taagaggaga gtccttctga aaatagtctg ataatctgca tacttgaaaa tattatcgct
    11101 acaatcaaaa aacgaaaaag atttcctggt ataaaatgtt caattaccaa tactccttga
    11161 aaagtaagaa ccgcaaaaga aacaaggagt aatgttgaaa gtttgaacag cgatactttc
    11221 tttttcaaaa ctctcaaaag aacgaatatc gacaggttca ctatcataat aagtaggcca
    11281 taataataaa gaggaatacc taatgaagtc ataactggtt ggtataaaga aaatgtcccc
    11341 cttgaaatac aaaataaaag ggcaagcgag aacaagagaa ataacaattt atgatttaag
    11401 gactttactt tcatttttat ttttgtcatt tctttatgta tcgcttcaga acacatgaaa
    11461 atagcagata ataatttgat gatttttatc gataaatcca atataagtgg caaaatcact
    11521 agataggaaa atagaaccgt ggaaacaaat ccagaaattg ctgctataat cgctcctatg
    11581 gaaaaatatg aggctgattt ctccataaaa tctttttcag tttttccttc tctcttaaac
    11641 atattaaata ttaacacttc aaaattacca ctcgctaaag ccaacatgcc tgttcttata
    11701 atttctataa ttaaaactgg aataaataaa gagcctttta tcaaactagg aagaaaaagt
    11761 aaagttataa gacacacaat ttccgcacca tttcctaata ctaacattaa tttcctatcg
    11821 aacttatcgg ataagtaacc tgttggaatc tgaactaaca acgaaattaa caaacataag
    11881 cccataatac ttgaaaaatc tgaaaaagaa agctttaaat acacactgaa aaatataacc
    11941 tctacaaccg ttataaatgc atcatcaaaa agtattctat ttatgaataa aattttctga
    12001 ccattgaaaa attgagtcat tggtaccccc cacattcctc aaatagcgga cataagttac
    12061 acgaggttga ttttcgatat tttcccgctc tccatatatt aaaaatcgaa cttgttcccc
    12121 atatgtaatc aaaacttgaa ccatcgttac ctaatttttc gatagatttt tgggtttgag
    12181 atactacagg acagtctgaa agtgtcaagt cactatttat aacgcaggca gctgttccag
    12241 caccacaacc taaagtttca gcggtattct cttcttttag gtaagttgtg acaattagat
    12301 tatctggtat ttttaaatct gagcatgctc gaactaaacc ttcataatcc atgaatagtc
    12361 gttctttttc taataatccc gttcccatgg gcataaatgg cattaatcgc aattctctac
    12421 accctaatgt ggcacacata tcaatcattt gttgaatggt agaattattt tcttttgtca
    12481 cgaccatagc aagccgtgta ggaacattct cttttactaa tagtgctaca ctttttattg
    12541 cactttcaaa tgttcctttc cctctgactg cgtcattgat taacttttgg ggagactcta
    12601 aagaaatttg aacctctttt aaatatttgg atttagaaag tattctaatt aactcttcat
    12661 ttctaaatag tttttgacca ttagttgaaa atgagtatga aattctcaat ttttctagtt
    12721 gaataataat atattcaaag tactcacatt ctgtcggttc accgcccaat agagaaacat
    12781 gggtaaattc tttatcttgt ataatatcta ggacctgatt tatttcatca agctccaact
    12841 cttttccttg ataatcttcc aaataacaaa atttacacct taaattacat ttgttggtaa
    12901 gcatccaagt caggaacagt ggatttttta ggtaattaat catcttactt ctccaatcta
    12961 taaaaaaata cagataattt ttattatctg tatcttaaca tataaaattg ggtggaaatt
    13021 ttcttttgga atatatgcca aagccctata atttttcaat ttcttcaaaa aggacctttg
    13081 cttctagtgg gaaaccataa tctgcaagag tttgcgcgtg ttttttcatt tcttctatcg
    13141 ctccgttttg tttttgcaat accttataat gagctttgtg atattcaaag aggatttttt
    13201 catagaaaaa attgatacct attcctattt cttttaaatg gttaatgtat ttaaaagctt
    13261 gcattaagtt ttctctccgt aaccaagtat caatgagatt taaaaatgtt cttattacga
    13321 tctgttgatt gagatgaatg gaatgataat aatttgattt tcctaaaatt tgcattccgt
    13381 aatactttag tgcattatca tcaaaatgtc gaagacaatt gccaaaaacc cacagttcat
    13441 agcgtcccca ttcgctgaca gattcaaggt agttcatcaa aaggtcagta tcttttttga
    13501 tatcctctgc attttgaacc attactaagt tggttttaac tactgtttca ttaattttat
    13561 agtatttatt ttcaggattt tgttgagatt tttctttcca aaaattatga atttctatga
    13621 ttttctcgat gtttttttgc gcataagcaa ccgctaactt gtgacgaaag gtgtattcat
    13681 ctgattgttc atagtcgtta taaagatttt gaaattcgtc taaatagaca tttgaatttt
    13741 ctaggacggt aaatagttta cccaccgtaa tctctgtttc tcctttttca aattttgcga
    13801 gctgagattc tgaaaaagaa ccaccagtca tttcttttaa ttttagatgc ttcgtttctt
    13861 tgataaaagc aatgattttt ccggttttta aatttttttc catttcattt tccctttgtc
    13921 atatattcca aattcattaa attatttgaa attattatac aactttgctt ttagcttgta
    13981 aactagatga aaaaactact gacagaaaag ctgtcagtag tttttatttt tctaaataat
    14041 ctaaagcgtc ctgaatagtt ttgacgggaa cgattttcat cttcgttttt agttttttag
    14101 ctgcggcttt ggctccaagg taattgttgc tactttcctt tttggtgcct gagtcaggca
    14161 ctaagaagac ctttgcccct tctttgctcg ctgtggctac ttttttatca acaccgccga
    14221 tttgaccaat gcttccgtcg tgttcaatcg ttccagttcc agcaatttcg cgaccgtttc
    14281 gcaaatcttt tcctgtcaac tgactgtaaa tttctagtgt aaacatcatc cccgcagagg
    14341 gaccaccgat tgaacccgcg ttgacagtaa ctttcggatt cgtcacgact tcagtatggt
    14401 caactaggct aatcccaatt cctgttttac cattagcaat tttgatgtat ttgccagttg
    14461 acttgtgctt tgtgccgtca attctcgtgt attcaatcgt tactgaatca ccgacttttt
    14521 gtttggaaac ataagcaatc atgtcggcac ttgatgtaaa ctgttgacca ttgactgctg
    14581 taatcgtatc tgcaagttct agcttatttt taaaggtcga atttttggca atatcaagga
    14641 cataaacgcc ttcatattta agttcataag gtttattagc taatttaaaa gcttgataaa
    14701 tcgctgtatt ctgtgccgtt tccatgtaaa actggttgac acggttgaac tgtgcgtcgt
    14761 taagtccacc agtcatttct tgctcactat aaatgcttgt aaaactatta aaatggctgt
    14821 aaatcattgt agcaagattt gctcgtgcaa tttggacagt cgtcaggaaa aaatcacctt
    14881 tatgttcatc ttttttgcct tcaactttga ccattttccc taaaggctcg gttgttccgg
    14941 gcatttccac atagtaactc gttggataaa ataaagctaa aagggcaaca acaattagac
    15001 caatcgagat tccccatttt aatttgggat taattttttt attttttttc atctaatttc
    15061 cttaattcac gactcacatt ttctggaacc caagcactga catcttgacc aaaggcatgt
    15121 aattctcgca tccgtgttga atttaatggt tcaagttctg gttttgctaa gaaaaagatg
    15181 gtttcaacgc ctgtcatctc catattaaaa tagaacatat ttttttcata ttctaaatct
    15241 tggctattac gcaaagaacg aaccagagct gtcacgccaa gtttttttgc gatattcact
    15301 gtcaaatcac gttcatgttt gatgactttg actttatgag tgactgacag acttgtcagt
    15361 gcttcttcta gcatttccac tcgtttatca gttggaaaaa gtggattttt ttggtcattt
    15421 ttaaaaatcc caacataaag ttgatcaaaa tgttgactgg cacgtttgat aacgtctaaa
    15481 tgaccatttg tcagtgggtc aaaagttcct gtaaagagtc caattttttc tgtcattact
    15541 tttttctttc ttaatttact gacagaattt ctgtcagtaa aagtcaaaat tcataaattg
    15601 aaattttaga aattccgtaa gttttttgtc tggtcagctc taatttccca atttggttag
    15661 ggagttcaac ttccttgtct gtttcacaga cgacaattac attttctgtc agtcgttttt
    15721 tctcttgcaa aagttctaag ttttcaacaa tttgttcttt agcataaggt gggtctaaga
    15781 ggactaaatc aaaagtctct gacaagtttg ataagactcg ttctgctgac atttttaata
    15841 attgaaattt ttcaggctct ttggtcatct tgatattttc caaaatgact tgttgagctg
    15901 ctctgtcttt ttcgacaaga atggcgtgat ccattcctct tgaaatggct tcaattgcca
    15961 aactgcctga gcctgcaaat aaatcaagaa cacgtccccc ttcaaaataa gggccaatca
    16021 tattaaaaat ggctccttta actttatcgg tggttggtct tgttgttttt cctgccaatg
    16081 ttttcagcgg tcttccgcca taatttcctg aaactactct catgaaaata attatatcac
    16141 aaaatttcaa atggagagcc gaatctccct gtaagccttg gtctaaaggt tctgtcagta
    16201 aaaattttct tattatttta ctgacaaaaa taagtttctc aaatcagaat ttcattctaa
    16261 cttttgaaac ttatttttgc ctatatttaa ctcatgaatg actttcatgc atccgaattg
    16321 ctcgtagtga gggcagcaca cctaatacaa taatgaaaaa catgatgatg gtcattccaa
    16381 tatttccata aagacttgag agggacacaa ggattcctga caagaccgaa gcgataggct
    16441 gagtcactga aaaagctcct gtataagttc ccacttggtc tccatccatt aaatcggccc
    16501 gcagagcctg tgaaaatgga accaaaatca tttcaccgat tgttgctacc aatgctgcaa
    16561 ccagttccca agttaaatca cgaccaagaa atgcaatcat gaagcccaaa ccttgcaaaa
    16621 taattccaat ggatattcca ctacttcgtg accaattttt ggttagtttg ttgactttcc
    16681 ccataaataa tacgatgact aaggtattga ccattaggaa aattgtcagc atccgttgtc
    16741 cataaacttc aattccaaaa atccttgctg ttctaaaact atcactcaaa tggactggaa
    16801 gataataatc aatttgatta aaaatcatcg caataaagac cgaagcaaat aaataataca
    16861 tgaaaatacg gtctttagca actgtgaaat aggctttaat aatgtttgat tcttgcttat
    16921 gctgctgagt atctggattg aaggattcat caatccaaaa aattacaacc aaacaactaa
    16981 cgatttcttc aattgtgata gccaaaagta accaaaccaa ataatctcgg aaaaaccagc
    17041 ctgaaagtcc tgaaccaatc atgattgcaa agttgataat ccagtattga atactataaa
    17101 cgactcgccg attttcactt gttgtcaaat ctacaatcat cgcttgactt gcggtgttaa
    17161 aaaagccaaa accaaaatta ataataagaa atcctaaaaa agtaacccaa ggattgaagt
    17221 aaaaagatga gtttgcaaat gttgctaaag ctccaccaaa accagtaatg gcagttgaga
    17281 aaatcatcac aggtcttctt ccctgaacgt cggacaaatg accagcataa agtccaacca
    17341 agaaaaccat aactgaacta atgactaaaa gtaatcccgt gattcctgca cccatatatt
    17401 tattgtagta gattgtcatt gagccaccca ctgtactaaa gcaaagcgtc ccaaaaaaat
    17461 tcatgattaa acgaatttta agtgtcggat gtaatccaaa aaaatctttc attttatttc
    17521 tttctgtttt ttttcaataa aaaatctatc ttgactcctt ttcaagataa attcctgttt
    17581 ttagaagtca tttttttaat taatttttgt tttctggtgt ctatttacag caataagcac
    17641 taaaataatc gctagaactt cagtcaatgc taagactaaa gaaactcctg ttgctttaat
    17701 cattggtgaa atcgaaacaa gtaaaccggc aagaatggag gcaatcggca tcttaattgc
    17761 ggcaacgcca ttgtaagaac caattttttc tggattcatc aaatctgcac ctaaagtttg
    17821 aacacttggt gtataaacaa tttcacctaa agtataaaca ataccggcaa tgaaaatagg
    17881 cgtaaacgtc gttgtcaaaa atgaaaaaat catcccaatt gccataaata aacttcccca
    17941 aataaatcct ttttggtgtg accagtcctt ggtcaatcga tttagggtgg tcattaatag
    18001 gaccactaat acacaagcta aaatcaaata aatcgtaagc atccgttgtc catagatttc
    18061 aaaaccaaaa aaagtgattg ttttaaaact atttgataaa tgaacaggca aaaaattatc
    18121 aaattgcatg ataataaaag tggtcgcaat attagcaccc ataaaaatca tgtaagtttt
    18181 atcttgtagc actgtcttat aggcctgaaa aatattttct gcttcttctt tggcctttac
    18241 aatcggtcta aaagtctcag tcattacaaa agtggttaag aaaaatgaga ctaagacagt
    18301 taaaagtaat atcactaaaa gtgcttcaaa tgctggtcta aaaagccaag cacctaatgc
    18361 tgctcctaaa ataactgaca agttttgcgc ccaataatcc aacataaaaa caactttacg
    18421 attttcagca tttgatgcat caataatcat ggcatttcct gcagtaatca caagattata
    18481 accaaaacta atcagcaaaa aagcaataaa agttgaccaa ggattcacgt gaccaggtaa
    18541 gtttgagcca atagctaaaa gagctcccaa aagttgaatc actgtcccaa aaaccatcac
    18601 tggttttcga ccatttcggt cagcaaaaaa acctgcaaga attcctgcga caaaagtggc
    18661 tactgcagat aaggcaagca aaatccctgt aattgcactt cccaaatgtt gattataata
    18721 aatggtcatt gaagaaaaaa cggtgccata tgaaaaggca cctaaaaaaa caattcctaa
    18781 acggagttgc aaatttttgt ctaaattcca aaactctttc atattattcc ttaaattctt
    18841 ttaaattttc taaatttatt aatttatcta taattgtagc atatttatac ttctaaaact
    18901 agatgaatta cagctttatc aaaataattc ttctacttat atcaattttt gttaaaataa
    18961 actgtaacca aacttaattt gatttgttat atatataaga ggggaggaaa tggtgaattt
    19021 aaaagaatat gaaaatgacg tcaatgatta tgcgatagaa atcactaaat accttatctc
    19081 tcgtggaagt cagttggtcg atgccgaaga tgccgtacag gatactctgg ttaaaatttt
    19141 aagtctggat attttcattg aacctgacaa attacgggct tttatgtatc gaacatctat
    19201 ccgaacttat attaatagtt ataatcggag taaacattat caaaaaatta ttaaaaattt
    19261 ggaaaaagaa ttggaaacag cagctttttt agttgagtct agcccacttc caaaaatcat
    19321 tgaacaactt tccccttatt ataaagaact tttaaatgca tactattatg aaaattgttc
    19381 aactaaacag cttgcagaat attttgaatg tagtttaagt aaaatcaaaa tcgaccttta
    19441 tcgagctcga aaaaagctta aaaaacaact tgaaaaagct ggttatgacc agtggctcct
    19501 ctaatcgtct catgaaagga tttaaaaatg cgtactctct taattttccc ttactttgtc
    19561 ttagctctca ctttattttt cggactgatt cgtctgttta tttttgcgat caataaaaca
    19621 cggcacaaac ttcaaacaac tgaatctatt tctaatctca acaaagattt tcataatttt
    19681 gccctaaaaa caaaaataaa acgttggggg ttaactactt ggattgcttt gactgtattt
    19741 tcagcattta tagttgttgg ttggcgagtg aactctgcta tcatggaaaa aaatttcttt
    19801 aaaacttttg attactctac cgctattttc accgcttccg ccccaaatgt tgcttataat
    19861 aatcagatta tcgatgatta tggcgtgttt agttctaatc ttcattcaga tacttataaa
    19921 gatattgatg gttatcatgt gccctgggaa tcttataatt tttcctttaa tgtttcgaat
    19981 gttgggggct taagtcttaa taccttgagt ccgtcagtaa attcaaatgc ctattttacc
    20041 caaacaacta atcaaaaaat tgctagtttt ttctctacaa atgccaacta caaatctaaa
    20101 gattataatg gaattctgcc tacccatgat gcagacaaaa tttcacaact ttcaaaccac
    20161 gtggcggaag ttgctgtcac ctttgataaa gcttatagtt acaacgaaat ccaaaaaatg
    20221 attcccgaaa atcttttaat taattggtat tggattggtt acaatgattc gaaatctctt
    20281 gatgctgctg gacaaacaaa ctggtttggc ttgatgagta atagcaatta tgctgaaaat
    20341 ggtaataatt cacagctcac tggaaaatta gacaatacta cttatcaaga ttttaaaaag
    20401 tcagtagctg ctattgcgaa aaagaaccaa atcacaatta acgactttag cccaagtaaa
    20461 gatgcactta aacaagttaa aaaatatcct actcttaaat cagctaaatt ttcgggggtc
    20521 attttaacag gacaaactaa gaattttgtg aattttgata aaaattcttg ggtttatgca
    20581 agtaatgttg ggcttacagt agaacttcgc cctgatatta agccacttaa ataataattt
    20641 tactgacagg atttgtcagt aagaaatgga tacaaaaaat cactgacaga aatcttgtca
    20701 gtgattttta tgacactttt aatcaaagat taaaggcggt cattcaattc tttgctgagt
    20761 tcttcaaatc ctggtttacc aagaagagcg aacatatttt tcttgtaagc ttcaacacct
    20821 ggttggttga atgggttaat tccgttcaag taaccagaaa caccgatagc aagttcaaag
    20881 aagtaaattg catatccaag tgtgaattcg tcttgttcag gcaatgtcac gatcatgttt
    20941 ggaacatttc cgtcagtgtg agcaagaagc acgccgtcag ctgctttttt gttaacgaag
    21001 tcaacatctt taccttgcaa gtatccaagt ccatcaaggt cagcgtcaag ttctggaatg
    21061 ttgatgtttt tacgtggttt ttcaatacgg attgctgttt caaaaacagt acgtgttcct
    21121 tcttgaatcc attgtcctaa tgagtgaagg tctgttgaga agttagctga agttgggtaa
    21181 attccttttt ggtctttccc ttctgattca ccagccaatt gtttccacca ttctgagaaa
    21241 tattgaaggc ttggttcgta attgatcaag atttctgaga acttaccttt acggtaaagg
    21301 atattgcgaa gtgcagcata ggcgtaagca tcattttcat gaacatttgt agaagtgtat
    21361 tctttacgcg cagcgttagc accttccatc aaagctgtaa tatcagcacc tgaagctgca
    21421 attggcaaaa gtccaacagc tgtcaatact gagaagcgtc caccaactga atctggaaca
    21481 acgaaagttt cccagttgtt tgcgtcagca ttaactttta cagcaccttt ttctttatca
    21541 gtggttgcgt aaatacgttt gtttgcttct tcacgaccgt attttttaac taacatttct
    21601 tcgaagacac ggaaagcaat cgctggttct gttgttgtac ctgatttaga gattacattt
    21661 acagagaaat ctttgtcagc aacgtaatct acaaggtcag ccaagtatga tgaagaaatt
    21721 gagttaccag cataaagaat acgtggtgct ttacgttctt cggcagtttg caagttaaca
    21781 aagctgttgc tcaaaaagtc aattgctgca cgtgcaccga ggtatgaacc accgataccg
    21841 ataacaataa gaacttctga atcagattga atttttttag ctgctttttg aatacgagca
    21901 aattcttctt tgtcgtaatc ttcaggaagg tcaagccatc cgatataatc gctcccagca
    21961 ccttttcctt cgtggagcaa tttagctgcc ccgtcgattt gccattggat ttcgtctaat
    22021 tcattttcag ctacaaatgg agtgagtttt gaatagtcaa atttaatatg agccatttta
    22081 attcctttca atttctcgtt ttttacgaga atttagctat tgaagaacga caacttttgc
    22141 attgttttat cttcgaattt tctagttcat tttatcactt tttcggcttt ttaacaatac
    22201 taaaggttat gtaagcgctt atttgtttag ctttctatct ctgaaacttt tccagctttg
    22261 agacagcttt ttttatcaaa acttagttta agatttcaat gaatatttat tgtcatcaaa
    22321 aaatttactg ataagataag tcctaacact tttgagggtg tcaaatctct ttgacgactg
    22381 acaaatcagt ctttcatgta aatttttgct aaaatattaa tgatgaaata tacatttgaa
    22441 attgaccttg accgttataa aaatctggcc caacaaaaac aaaagacaca taagaaattt
    22501 ttagctggcc ttgccaaaaa accaccaaag caattagata aaatcgttaa agaagttcat
    22561 gaagaggttt ttttagaaat tgattgcacc aaatgtgcta attgttgcaa aaccttaggt
    22621 cctctttgga cagaggccga tattgaacgc gtcgccaaac atttaaaaat gaaagtgagt
    22681 gactttgaag ccgcatatct ccgaactgac gaagatggtg acaaagtttt tcaaaccatg
    22741 ccttgtccgt ttcttggttc tgacaatctc tgtagcattt acgaagttcg tcctaaagct
    22801 tgtcgcgaat ttccccatac tgaccgtaaa aagatttatc aaatcaataa tttaacgata
    22861 aaaaatacac tttattgtcc agctgcttat gaatttgttg agaaattatc ttatagactc
    22921 aaataaaaat tactgacagg tctgtcagta atttttttat tatgccaaaa gttctttcaa
    22981 agcttctttt gtatctgtca gtgaatgtcc caaggctttt tcaaaatctt tagattccac
    23041 atctaaatct tttgcttcaa tatctttttg gaagccgagg aaaagttccg ctacaaaatc
    23101 tggaagtcca gtttcaacta aatgactgac aaaagctttg tcatcagcag cgactacttc
    23161 aaattcctta tcagaaactg cttttagtgc ttgagcaagt tcggcgtaag tcaatatttt
    23221 tcctgaaagc tccaaaactt ctggaaaatc tgctccagca agtgcttttg ctccaacttc
    23281 tgcatattca cgtttcaaag cccagcccac tttacctgtt ggtgcattgt aaacaaattt
    23341 tccagttgaa agtgcagcag caataattgg catttcattt tcaaagtacc agttattacg
    23401 taaaaatgtg tgggcaattc ctgatttttc aatcgccttt tcagtataga tgtggtcagc
    23461 agctaagtca cttgttgccc tttctgcttg aggaaaactt gtataagcaa tataagaaat
    23521 tccagcactt ttggctgcat caaccacatt ttgatgctca gcttgacgat ttcccggcgc
    23581 tcctgaaaca aaaagcaaac ggtcaattcc tgtaaatgct tgttctaaag cagttaaatc
    23641 cgaataatct gccaaacgta catcgaaccc tgccgctttg agtggagctg ctttttcttc
    23701 tgtgcgagcc aaaaccacaa tatcagaaat tggaaccaat tctttcaaaa atccgagtgc
    23761 ataagtaccg tatccacctg ttgcacctgt tactaaatat ttcatgttaa atcctccatt
    23821 tatttattat tttttatatt ttaaagtagc ttgctttttt gactacctaa gtgtataata
    23881 tcattgtact accactatgt aaa
//
