LOCUS       NZ_CP066300            26032 bp    DNA     circular CON 30-JAN-2024
DEFINITION  Lactococcus lactis strain WiKim0098 chromosome.
ACCESSION   NZ_CP066300
VERSION     NZ_CP066300.1
KEYWORDS    RefSeq.
SOURCE      Lactococcus lactis
  ORGANISM  Lactococcus lactis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Lactococcus.
REFERENCE   1  (bases 1 to 2424276)
  AUTHORS   Kim,T.W.
  TITLE     Genomic analysis of Lactococcus lactis WiKim0098
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2424276)
  AUTHORS   Kim,T.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-NOV-2020) Microbiology and Functionality Research
            Group, World Institute of Kimchi, 86, Kimchi-ro, Nam-gu, Gwangju,
            Gwangju, Gwangju 61755, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FLYE v. 2.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 342.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 08:40:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,477
            CDSs (total)                      :: 2,390
            Genes (coding)                    :: 2,331
            CDSs (with protein)               :: 2,331
            Genes (RNA)                       :: 87
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 36 of 59
            Pseudo Genes (incomplete)         :: 22 of 59
            Pseudo Genes (internal stop)      :: 12 of 59
            Pseudo Genes (multiple problems)  :: 10 of 59
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:11:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 626980
            Orig. end                         :: 653012
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP066300.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26032
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26032
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26032
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16032](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16032
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(422..436)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.19"
                     /tool="antismash"
     misc_feature    complement(757..774)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            949..2169
                     /locus_tag="LacL0098_RS03155"
                     /old_locus_tag="LacL0098_03155"
     CDS             949..2169
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864227.1"
                     /locus_tag="LacL0098_RS03155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03155"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_104143412.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 5.3e-30,
                     bitscore: 101.6, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIISTMVDVYVVYYPIILSFIWASGAFLSRWKERDKKAIDETKEF
                     EKISIVISAYNEEETIEEVLLSLRNLNYPSLEIFIVDDKSSDRTLEKIYEVKKSFDDWE
                     ALTILEQKENKGKATALNVALQQVNSKYMLVIDADSYLSKDALSYLLAELTSSSDIGAV
                     TGRPIVRNRTTLLGKLQTLEYLSVIDAIKRAQSLFLGAIMTVSGVIVMYRVEALKEIGG
                     FNTEVMTEDIDVTWRLHRNQWKVKYVPKALSYILVPENLKSLLKQRKRWAVGGVEVLIS
                     NLSWVFKRGEFKYRFLLIEMICSHIWSWFFLIESYQYFLQMLLNQEFKVSGQIIVIFVL
                     ISFFVFFLGLDNDKGESRLSLTDKLIFPAYLVAYWFLNLISALSAELVVLTNRTNKGKW
                     ESPDRGV"
     gene            2442..3335
                     /locus_tag="LacL0098_RS03160"
                     /old_locus_tag="LacL0098_03160"
     CDS             2442..3335
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864229.1"
                     /locus_tag="LacL0098_RS03160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03160"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_181022882.1"
                     /transl_table=11
                     /translation="MKFSKKNIFLILMFGLIAILVFMSTRETKKYVQDGKKEQPDFAYE
                     SLLKDNDGIIVLCYHRVLKDTVVTNFAYSISHNSQLHEYNVFLQDFEQQMTFLKKNHIK
                     VLTSSELIEKLNKKEVIGKAVVVTFDDIDKSLPENAYPIMKKLDLPFTQFIITGKVGQI
                     IDGSQMSTWKEIKKMNENPLVTSGLHTNDLHYQENFEPILSTNISKKVVQKDYQKSQKA
                     FDEKLDQKGKVFAYPYGAQNKDLEDYMLQDGIQGIFTLSPGVVTNETLYSNIPRLIVTK
                     DNWKTIKHWLLSEGAQ"
     misc_feature    3364..3373
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.78"
                     /tool="antismash"
     gene            3418..3657
                     /locus_tag="LacL0098_RS03165"
                     /old_locus_tag="LacL0098_03165"
     CDS             3418..3657
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LacL0098_RS03165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LacL0098_03165"
                     /product="hypothetical protein"
                     /protein_id="WP_236253327.1"
                     /transl_table=11
                     /translation="MVGINLFTTSNVFAADYGNKFITGHELTDDLGNPKTDFGIYDDVQ
                     AHWDFDIPVGSVTQGYTMSINVPNLLTLSKDVTF"
     gene            3715..4248
                     /locus_tag="LacL0098_RS03170"
                     /old_locus_tag="LacL0098_03170"
     CDS             3715..4248
                     /GO_function="GO:0005518 - collagen binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017547.4"
                     /locus_tag="LacL0098_RS03170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03170"
                     /product="collagen binding domain-containing protein"
                     /protein_id="WP_181022881.1"
                     /transl_table=11
                     /translation="MVTFTFSKLVENATSNIKGLFSVWVNWDEQKVEEDTKVVVDCKDG
                     GTTEVNIGPAIGPDKDEVLYKWEWVDENDSTLIHWRVRINYAKENIQKAVYTDIIGGNQ
                     NLVSGSISVANVTYSSDGENYNIDSYYPQASILENGVNGFTVNLGDISNTIIVDYSTRA
                     TDGGFLNSIKIEED"
     gene            4320..4558
                     /locus_tag="LacL0098_RS12565"
                     /old_locus_tag="LacL0098_03175"
                     /pseudo=""
     CDS             4320..4558
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017548.4"
                     /locus_tag="LacL0098_RS12565"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03175"
                     /product="Cna B-type domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKLSISGEKTWIDDNNARGLRPSFIGIELYRNVEKVYSRDVTAKK
                     IGNIRLPIWISMMKVGNFTIMM"
     gene            4562..4783
                     /locus_tag="LacL0098_RS12345"
     CDS             4562..4783
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LacL0098_RS12345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_236253328.1"
                     /transl_table=11
                     /translation="MHNFINTIISVKVETPEKTDQSITAPSSSSQVMSTSSSSMESETS
                     EELPKTGDSPKDFVKELGILQLISGGLE"
     gene            complement(4890..6260)
                     /gene="brnQ"
                     /locus_tag="LacL0098_RS03185"
                     /old_locus_tag="LacL0098_03185"
     CDS             complement(4890..6260)
                     /GO_function="GO:0015658 - branched-chain amino acid
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0015803 - branched-chain amino acid
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="brnQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003129615.1"
                     /locus_tag="LacL0098_RS03185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03185"
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="WP_195927986.1"
                     /transl_table=11
                     /translation="MEEKLVGKDYLFIGSMLFGLFFGAGNLIFPIHMGQEAGAAISQAN
                     FGFLITAVSFPFLGIIALGISQSNGVFELTSRVNRIYAYIFTILLYLVIGPFFALPRLA
                     TTSFEIGISPFLSHELQAPLLALFSILFFGTAWFLSRKPTKLLDYIGKFLNPLFLVLLG
                     IILVTAFTHPLGKVSQAEIGKAYQASPILTGFTQGYNTLDALAALAFGIIIITTIRQRG
                     VKNPKIIAKETIKAGLISVGLMAIIYTCLSYLGAMSLGQFAISENGGIALAQISNHYLG
                     NFGMIILALIVIIACLKTAVGLMSAFSETFVELFPKKEYRFYLIIVSILPCIFANIGLT
                     KIIELSVPVLMFLYPLAIILILLTLLSPLFKHSRLVYQITTAFTLLAAIIDGLNALPAN
                     LHTITFISVIINFAKDFLPFFSLGMGWILPAVLGFIIGCLCQITITVYKNKKSSTLS"
     gene            complement(6497..6769)
                     /locus_tag="LacL0098_RS03190"
                     /old_locus_tag="LacL0098_03190"
     CDS             complement(6497..6769)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257361.1"
                     /locus_tag="LacL0098_RS03190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03190"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_021214922.1"
                     /transl_table=11
                     /translation="MNIIERENLFELLSDKGEVIGEMAYMPMNNSIIITHTGVSLDYRG
                     QGLAEKLVLAGIQKARREQLKLGATCPYAVKYFREHKEELTDVLK"
     gene            complement(6769..7041)
                     /locus_tag="LacL0098_RS03195"
                     /old_locus_tag="LacL0098_03195"
     CDS             complement(6769..7041)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864233.1"
                     /locus_tag="LacL0098_RS03195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03195"
                     /product="(4Fe-4S)-binding protein"
                     /protein_id="WP_104143394.1"
                     /transl_table=11
                     /translation="MSNSKLFGNDVTEEELLKKNYRKYHGGKMDIYYNVAICEHAGECV
                     RGNPLVFEVGRKPWIIPDNGDVASNQSVINRCPSGALKYLAKEKN"
     misc_feature    complement(7054..7069)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 26.21"
                     /tool="antismash"
     misc_feature    7302..7318
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.28"
                     /tool="antismash"
     gene            complement(7576..8723)
                     /locus_tag="LacL0098_RS03200"
                     /old_locus_tag="LacL0098_03200"
     CDS             complement(join(7576..8471,8471..8723))
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558257.1"
                     /locus_tag="LacL0098_RS03200"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="LacL0098_03200"
                     /product="IS3 family transposase"
                     /protein_id="WP_200984848.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MARRKFDKQFKNSAVKLILEEGYSVKEVSQELEVHANSLYRWVQE
                     VEEYGESAFPGNGTALADAQHKIKLLEKENRYLQEELELPKKVPGLLEAKQVKRFEFLL
                     KHHGKIKIKHAVKVLKVSRSGFYEYMHRRPSKQQVEREILSEKIKAVFHEHKGRYGAVR
                     ITKVLHNTGIMTNTKRVGKLMHLMGLYAKGSRYKYKHYNRKGASLSRPNLINQIFKATA
                     PNKVWLGDMTYIPTKEGTLYLAVNIDVFSRKIVGWSMSSRMQDKLVRNCFLQACGKEHP
                     QPGLIVHTDQGSQYTSSRYQSTLRQVGAQSSMSRKGNPYDNAMMESFYKTLKRELINDA
                     HFETRAEATQEIFKYIETYYNTKRMHSGLDYKSPKDFEKYNS"
     misc_feature    complement(9032..9052)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.64"
                     /tool="antismash"
     gene            9720..9893
                     /locus_tag="LacL0098_RS03205"
                     /old_locus_tag="LacL0098_03205"
     CDS             9720..9893
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570405.1"
                     /locus_tag="LacL0098_RS03205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03205"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_015425978.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.9e-22, bitscore:
                     75.5, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 1.4e-05, bitscore:
                     21.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTKDFNLDLVSVSKKDSGASPRITSISLCTPGCKTGALMGCNMK
                     TATCNCSIHVSK"
     CDS_motif       9720..9788
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSTKDFNLDLVSVSKKDSGASPR"
                     /locus_tag="LacL0098_RS03205_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9789..9893
                     /prepeptide="core"
                     /locus_tag="LacL0098_RS03205_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="26.70"
                     /molecular_weight="3313.0"
                     /monoisotopic_mass="3310.6"
                     /core_sequence="ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSTKDFNLDLVSVSKKDSGASPR"
                     /leader_location="[9719:9788](+)"
                     /alternative_weights="3331.0"
                     /alternative_weights="3349.0"
                     /alternative_weights="3367.0"
                     /alternative_weights="3385.1"
     gene            10001..12982
                     /locus_tag="LacL0098_RS03210"
                     /old_locus_tag="LacL0098_03210"
     CDS             10001..12982
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864234.1"
                     /locus_tag="LacL0098_RS03210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03210"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_029344966.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4e-85, bitscore:
                     283.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.1e-07,
                     bitscore: 28.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.8e-16, bitscore:
                     56.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKSSFKAQPFLVRNTILSPNDKRSFTEYTQVIETVSKNKVFLEQ
                     LLLANPKLYDVMQKYNAGLLKKKRVKKLFESIYKYYKRSYLRSTPFGLFSETSIGVFSK
                     SSQYKLMGKTTKGIRLDTQWLIRLVHKMEVDFSKKLSFTRNNANYKFGDRVFQVYTINS
                     SELEEVNIKYTNVYQIISEFCENDYQKYEDICETVTLCYGDEYRELSEQYLGSLIVNHY
                     LISNLQKDLLSDFSWNTFLTKVEAIDEDKKYIIPLKKVQKFIQEYSEIEIGEGIEKLKE
                     IYQEMSQILENDNYIQIDLISDSEINFDVKQKQQLEHLAEFLGNTTKSVRRTYLDDYKD
                     KFIEKYGVDQEVQITELFDSTFGIGAPYNYNHPRNDFYESEPSTLYYSEEEREKYLSMY
                     VEAVKNHNVINLDDLESHYQKMDLEKKSELQGLELFLNLAKEYEKDIFILGDIVGNNNL
                     GGASGRFSALSPELTSYHRTIVDSVERENENKEITSCEIVFLPENIRHANVMHTSIMRR
                     KVLPFFTSTSHNEVLLTNIYIGIDEKEKFYARDISTQEVLKFYITSMYNKTLFSNELRF
                     LYEISLDDKFGNLPWELIYRDFDYIPRLVFDEIVISPAKWKIWGRDVNSKMTIRELIQS
                     KEIPKEFYIVNGDNKVYLSQENPLDMEILESAIKKSSKRKDFIELQEYFEDENIINKGQ
                     KGRVADVVVPFIRTRALGNEGRAFIREKRVSVERREKLPFNEWLYLKLYISINRQNEFL
                     LSYLPDIQKIVANLGGNLFFLRYTDPKPHIRLRIKCSDLFLAYGSILEILKRSRKNRIM
                     STFDISIYDQEVERYGGFDTLELSEAIFCADSKIIPNLLTLIKDTNNDWKVDDVSILVN
                     YLYLKCFFQNDNKKILNFLNLVSPKKVKENVNEKIEHYLKLLKVNNLGDQIFYDKNFKE
                     LKHAIKNLFLKMIAQDFELQKVYSIIDSIIHVHNNRLIGIERDKEKLIYYTLQRLFVSE
                     EYMK"
     aSDomain        10424..10687
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LacL0098_RS03210_Lanthipeptide_LanB_R
                     RE.1"
                     /evalue="2.60E-09"
                     /identifier="RREFam001.1"
                     /label="LacL0098_RS03210"
                     /locus_tag="LacL0098_RS03210"
                     /protein_end="229"
                     /protein_start="141"
                     /score="28.7"
                     /tool="antismash"
                     /translation="FTRNNANYKFGDRVFQVYTINSSELEEVNIKYTNVYQIISEFCEN
                     DYQKYEDICETVTLCYGDEYRELSEQYLGSLIVNHYLISNLQK"
     gene            12993..14795
                     /locus_tag="LacL0098_RS03215"
                     /old_locus_tag="LacL0098_03215"
     CDS             12993..14795
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015425980.1"
                     /locus_tag="LacL0098_RS03215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03215"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_095586746.1"
                     /transl_table=11
                     /translation="MDEVKEFTSKQFFNTLLTLPSTLKLIFQLEKRYAIYLIVLNAITA
                     FVPLASLFIYQDLINSVLGSGRHLINIIIIYFIVQVITTVLGQLESYVSGKFDMRLSYS
                     INMRLMRTTSSLELSDYEQADMYNIIEKVTQDSTYKPFQLFNAIIVVLSSFISLLSSLF
                     FIGTWNIGVAILLLIVPVLSLVLFLRVGQLEFLIQWQRASSERETWYIVYLLTHDFSFK
                     EIKLNNISNYFIHKFGKLKKGFINQDLAIARKKTYFNIFLDFILNLINILTIFAMILSV
                     RAGKLLIGNLVSLIQAISKINTYSQTMIQNIYIIYNTSLFMEQLFEFLKRESVVHKKIE
                     DTEICNQHIGAVKVINLSYVYPNSNAFALKNINLSFEKGELTAIVGKNGSGKSTLVKII
                     SGLYQPTMGIIQYDKMRSSLMPEEFYQKNISVLFQDFVKYELTIRENIGLSDLSSQWED
                     EKIIKVLDNLGLDFLKTNNQYVLDTQLGNWFQEGRQLSGGQWQKIALARTFFKKASIYI
                     LDEPSAALDPVAEKEIFDYFVALSENNISIFISHSLNAARKANKIVVMKDGQVEDVGSH
                     DVLLRRCQYYQELYYSEQYEDNDE"
     misc_feature    complement(13001..13016)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            14788..16032
                     /locus_tag="LacL0098_RS03220"
                     /old_locus_tag="LacL0098_03220"
     CDS             14788..16032
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864236.1"
                     /locus_tag="LacL0098_RS03220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03220"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_015425981.1"
                     /sec_met_domain="LANC_like (E-value: 1.7e-73, bitscore:
                     244.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKNIKRNVEKIIAQWDERTRKNKENFDFGELTLSTGLPGIILM
                     LAELKNKDNSKIYQKKIDNYIEYIVSKLSTYGLLTGSLYSGAAGIALSILHLREDDEKY
                     KNLLDSLNRYIEYFVREKIEGFNLENITPPDYDVIEGLSGILSYLLLINDEQYDDLKIL
                     IINFLSNLTKENKGLISLYIKSENQMSQSESEMYPLGCLNMGLAHGLAGVGCILAYAHI
                     KGYSNEASLSALQKIIFIYEKFELERKKQFLWKDGLVADELKKEKVIREASFIRDAWCY
                     GGPGISLLYLYGGLALDNDYFVDKAEKILESAMQRKLGIDSYMICHGYSGLIEICSLFK
                     RLLNTKKFDSYMEEFNVNSEQILEEYGDESGTGFLEGISGCILVLSKFEYSINFTYWRQ
                     ALLLFDDFLKGGKRK"
     gene            16029..16766
                     /locus_tag="LacL0098_RS03225"
                     /old_locus_tag="LacL0098_03225"
     CDS             16029..16766
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570409.1"
                     /locus_tag="LacL0098_RS03225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03225"
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_200984849.1"
                     /transl_table=11
                     /translation="MRRYLILIVALIGITGLSGCYQTSHKKVRFDEGSYTNFIYDNTSY
                     FVTDKEIPQENANNSKVKFYKLLIVDMKSEKLLSSSNKNSVTLVLNNIYEASDKSLCMG
                     INDRYYKILPESDKGAVKALRLQNFDVTSDISDDNFVIDKNDSRKIDYMGNIYSISDTT
                     VSDEELGEYQDVLAEVRVFDSVSGKSIPRSEWGRIDKDGSNSKQSRTEWDYGEIHSIRG
                     KSLTEAFAVEINYDFKLATKVGN"
     gene            16768..18816
                     /locus_tag="LacL0098_RS03230"
                     /old_locus_tag="LacL0098_03230"
     CDS             16768..18816
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570410.1"
                     /locus_tag="LacL0098_RS03230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03230"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_029344968.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5e-48, bitscore:
                     161.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKILGFLFIVCSLGLSATVHGETTNSQQLLSNNINTELINHNSN
                     AILSSTEGSTTDSINLGAQSPAVKSTTRTELDVTGAAKTLLQTSAVQKEMKVSLQETQV
                     SSEFSKRDSVTNKEAVPVSKDELLEQSEVVVSTSSIQKNKILDNKKNRANFVTSSQLIK
                     EKPSNSKDASGVIDNSASPLSYRKAKEVVSLRQPLKNQKVEAQPLLISNSSEKKASVYT
                     NSHDFWDYQWDMKYVTNNGESYALYQPSKKISVGIIDSGIMEEHPDLSNSLGNYFKNLV
                     PKGGFDNEEPDETGNPSDIVDKMGHGTEVAGQITANGNILGVAPGITVNIYRVFGENLS
                     KSEWVARAIRRAADDGNKVINISAGQYLMISGSYDDGTNDYQEYLNYKSAINYATAKGS
                     IVVAALGNDSLNIQDNQTMINFLKRFRSIKVPGKVVDAPSVFEDVIAVGGIDGYGNISD
                     FSNIGADAIYAPAGTTANFKKYGQDKFVSQGYYLKDWLFTTTNTGWYQYVYGNSFATPK
                     VSGALALVVDKYGIKNPNQLKRFLLMNSPEVNGNRVLNIVDLLNGKNKAFSLDTDKGQD
                     DAINHKSMENLKESRDTMKQEQDKEIQRNTNNNFSIKNDFHNISKEVISVDYNINQKMA
                     NNRNSRGTVSVRSQEILPVTGDGEDFLPALGIVCISILGILKRKTKN"
     gene            18885..19571
                     /locus_tag="LacL0098_RS03235"
                     /old_locus_tag="LacL0098_03235"
     CDS             18885..19571
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014734918.1"
                     /locus_tag="LacL0098_RS03235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03235"
                     /product="response regulator transcription factor"
                     /protein_id="WP_058219594.1"
                     /transl_table=11
                     /translation="MYKILIVDDDQEILKLMKTALEMRNYEVATHQNISLPLDITDFQG
                     FDLILLDIMMSNIEGTEICKRIRREISIPIIFVSAKDTEEDIINGLGIGGDDYITKPFS
                     LKQLVAKVEANIKREERNKHAVHVFSEIRRDLGPITFYLEERRVCVNGQTIPLTCREYD
                     ILELLSQRTSKVYTREDIYDDVYDEYSNALFRSISEYIYQIRSKFAPYDINPIKTVRGL
                     GYQWHG"
     gene            19564..20907
                     /locus_tag="LacL0098_RS03240"
                     /old_locus_tag="LacL0098_03240"
     CDS             19564..20907
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864239.1"
                     /locus_tag="LacL0098_RS03240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03240"
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="WP_012897846.1"
                     /transl_table=11
                     /translation="MGKKYSMRRRIWQAVIEIIIGTCLLILLLLGLTFFLRQIGQISGS
                     ETIRLSLDSDNLTISDIERDMKHYPYDYIIFDNDTSKILGGHYVKSDVPSFVASKQSSH
                     NITEGEITYTYSSNKHFSVVLRQNSMPEFTNHTLRSISYNQFTYLFFFLGEIILIIFSV
                     YHLIREFSKNFQAVQKIALKMGEITTFPEQEESKIIEFDQVLNNLYSKSKELAFLIEAE
                     RHEKHDLSFQVAALSHDVKTPLTVLKGNIELLEMTEVNEQQADFIESMKNSLTVFDKYF
                     NTMISYTKLLNDENDYKARISLEDFLIDLSVELEELSTTYQVDYQLVKKTDLTTFYGNT
                     LALSRALINIFVNACQYAKEGEKIVSLSIYDDEKYLYFEIWNNGHPFSEQAKKNAGKLF
                     FTEDTGRSGKHYGIGLSFAQGVALKHQGNLILSNPQKGGAEVILKIKK"
     gene            21006..21683
                     /locus_tag="LacL0098_RS03245"
                     /old_locus_tag="LacL0098_03245"
     CDS             21006..21683
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012897845.1"
                     /locus_tag="LacL0098_RS03245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03245"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_015425986.1"
                     /transl_table=11
                     /translation="MQVKIQNLSKTYKEKQVLQDISFDIKSGTVCGLLGVNGAGKSTLM
                     KILFGLISADTGKIFFDGQEKTNNQLGALIEAPAIYMNLSAFDNLKTKALLFGISDKRI
                     HETLEVIGLAETGKKRAGKFSLGMKQRLGIGMAILTEPQFLILDEPTNGLDPDGIAELL
                     NLILKLKAKGVTILISSHQLHEISKVASQIIILNKGKIRYNHANNKEDDIEQLFFKIVH
                     GGM"
     gene            21685..22413
                     /locus_tag="LacL0098_RS03250"
                     /old_locus_tag="LacL0098_03250"
     CDS             21685..22413
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864241.1"
                     /locus_tag="LacL0098_RS03250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03250"
                     /product="lantibiotic ABC transporter permease"
                     /protein_id="WP_014570414.1"
                     /transl_table=11
                     /translation="MKRIIASEAIKLKKSGTLRLVLIIPFVTLFIAFLMGGIQIFSVFS
                     IYWWETGFLFLLMSLLFLYDIKSEEQAGNFQNVKWKKLSWKIHLAKMLLIWLRGILASI
                     VLIILLYLVAFVFQGIVVVDFMKVSVALIAILLAASWNLPFIYLIFKWINTYVLLAANT
                     LICLIVAPFVAQTPVWFLLPYTYHYKVTESLLNIKPSGDLLTGKINFSIWEVLLPFGLS
                     IVVTIGVSYLLKGVIEHDKK"
     gene            22400..23044
                     /locus_tag="LacL0098_RS03255"
                     /old_locus_tag="LacL0098_03255"
     CDS             22400..23044
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570415.1"
                     /locus_tag="LacL0098_RS03255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03255"
                     /product="histidine kinase"
                     /protein_id="WP_015425987.1"
                     /transl_table=11
                     /translation="MIRSECLKLKNSLGFYLVFLFTLLELLTVPIYLAFGRSHVSMTDL
                     SLMIFLFFPLLVTILSILIFEQESLANRFQEINVNKKSSRIWLSKLIVVDFLLFFPSAM
                     IWIITGVSQAVGQQGMMIATASWLMAIFLNHFHLLLTFIINRGGSMIIAIIEILLIIFA
                     SNKVLLAAYWCPIALPVNFMINGRCAYLIAAVGWIVLSTIILVALSKKKIR"
     gene            complement(23558..24651)
                     /locus_tag="LacL0098_RS03260"
                     /old_locus_tag="LacL0098_03260"
                     /pseudo=""
     CDS             complement(23558..24651)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086896442.1"
                     /locus_tag="LacL0098_RS03260"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03260"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQKRYSQEFKDTLLDFYHSGQSVTQLSKEYGVAPATIYKWIDLYS
                     KSNESSVSKDDFLELKRQLAKVKEERDILKKY"
     gene            complement(24741..25712)
                     /locus_tag="LacL0098_RS03265"
                     /old_locus_tag="LacL0098_03265"
     CDS             complement(24741..25712)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017371276.1"
                     /locus_tag="LacL0098_RS03265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LacL0098_03265"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_017864246.1"
                     /transl_table=11
                     /translation="MGAKKVIKLEDVANKAGVSVTTVSRVINRKGYLSDATISKVEKAM
                     QDLHYIPNAAARSLQGKSLKLIGLVFPTIKNIFYAELIEKIEQALFKRGYKAMLATTEH
                     DEQKERDYLALLLSNQVDGIIYGSHNLKAHDYIAIEAPIVAFDRLLTPETTVVSSDNFE
                     GGILATKALINSGSKKIAIFTGNDNTNSPTYLRRDGYLLELERNQLKPHIIKIPSQWTL
                     LRKKVEIKKILENNDFDGVFCTDDLTAILVKDLASNLKKSLNVVGFDGTEFIENYYPNL
                     TTIKQPINDLAELLVDLIIRKIDGDNIDITYQLPVQLHYGID"
ORIGIN
        1 atgatatgac aattcattcc actttaggaa ttttttggat tgggataaga acgattttaa
       61 ttacttgtgt gcccttgttt ttagtagcaa ctggattttt aatgaatcga aaagagttaa
      121 atgctcaata tgttctggga atagttcctg tcatcatttc ttatataggt atatctttat
      181 tagtatgggg agttctatct cttgttggaa aaggaagcga cttctctaca gcgataaatg
      241 gaatttttga ttattcaacc gattcttact cttggtatgt tgaaatgtat ttaggacttt
      301 atctttttat ccctttatta aatattatct ggaattataa aaaagaaatc aaaaattatc
      361 atttatatat tgtcttcatc gcaagtttgc taacattctt accctcttta ttaaatagtt
      421 ttggaaaagt tattccagac tattggcaaa tttgttatcc cgttagttat tattttatcg
      481 gagcttgcct ttatacttat caaaatgaaa taaagaaaat ttcaatagga aaacttgtta
      541 cagcattctt aagtgcactt acaattttta ctttgacgga cacttttgta agttggaatc
      601 aagaattcca gtggctagac cacaatgatt attttggtta tcaaacagcc ataatgacag
      661 tattagttat agcaatcttg tggagaattc ccattccaaa atggagcgtt agggtgctaa
      721 aggctctgtc taccgccact ttgactatct atcttatatc cgatttaacg gatcagtttg
      781 tctatggatt ttttaagcat gaaatttcaa acttaagtca acgagtgata gcaggaccga
      841 ttattattcc agtagccttt actagtgcgg ctttactagg gatttttgtg ggaaaaattt
      901 taaattttcc ttttaagaga aaaaaagaaa gaaaggaaaa ttaaaactat gataatctca
      961 acaatggtag atgtttatgt tgtttattat ccgattatct tgtctttcat ttgggcaagt
     1021 ggtgcttttt tatctcggtg gaaagaaaga gataagaaag caattgatga aacaaaagaa
     1081 tttgaaaaaa ttagtattgt tatttctgcg tacaatgaag aagaaacgat tgaggaagtt
     1141 ttattatcac tacgtaatct aaattaccct tccctagaaa tctttattgt tgatgataag
     1201 agtagtgacc gcactttgga gaaaatttat gaagtaaaaa aatctttcga cgattgggaa
     1261 gcattaacta ttcttgaaca aaaggaaaat aagggaaaag ccacggcttt aaatgttgct
     1321 ttgcaacaag ttaacagcaa gtatatgctt gttattgatg cggattcata tctttctaaa
     1381 gatgctctat cttatttatt ggccgaatta acttctagtt cagatattgg ggctgtgact
     1441 ggacgaccta ttgttagaaa cagaacaact ctattgggga aattacaaac cttagagtat
     1501 ttaagtgtga ttgatgctat taagagagca caaagtcttt ttctaggtgc aataatgacc
     1561 gtatcaggtg tgattgttat gtatcgtgta gaggctttga aagaaattgg gggctttaat
     1621 accgaagtga tgacggaaga cattgatgtt acttggcgac ttcatcgtaa tcaatggaaa
     1681 gtcaaatatg tacctaaagc cttaagctat attctcgttc ctgaaaattt aaaatctctt
     1741 ttaaagcaac ggaaaagatg ggcagttggt ggagtagaag tattaatttc aaatttatca
     1801 tgggttttta aaagaggaga atttaaatat cggtttcttt tgattgaaat gatttgtagt
     1861 catatttgga gttggttttt cttaatagaa tcttatcagt attttctcca aatgctgtta
     1921 aatcaagaat tcaaagtatc gggtcaaatt atcgtgattt ttgttcttat ttcatttttt
     1981 gtattctttt taggacttga taatgataaa ggtgagagtc gcttatcttt gactgataaa
     2041 ttaatatttc cagcttatct tgttgcttat tggtttctaa atttgattag tgctctttct
     2101 gctgaacttg ttgttttaac taatcgtaca aataaaggaa aatgggaaag tcctgataga
     2161 ggggtgtaat aatggaatta gtaatacgta aaaagatgaa aaaacgacat tttttagaat
     2221 ttttggctgt ttcactatgt tggctgttta tattaactgt tttcattctt ttgttaatct
     2281 ctttgctggg gatatatagt gatggaatta tctctgtttt tgtaatcatt gggtttccaa
     2341 taacaaattg ggaagatata atttatgatt tgttttgtct tctttcaata ttaacgattc
     2401 ctagtcttta tattttaacg aaggaggctt agatttataa tatgaaattt agtaaaaaga
     2461 atattttttt gatattgatg tttggtctta ttgctatatt ggtgtttatg tccacacgtg
     2521 aaacaaaaaa atatgtacaa gatggaaaaa aggagcagcc agattttgct tatgagagtt
     2581 tgcttaaaga caatgatgga attattgttc tttgttatca ccgtgtgtta aaagatacgg
     2641 tggttacaaa tttcgcttat tcaatttcgc ataattctca actccatgaa tataatgtat
     2701 tcttgcaaga ttttgaacag caaatgacat ttttaaagaa aaatcatatt aaagttttga
     2761 ctagttcaga actgatagag aagcttaata aaaaagaggt gattggcaag gcagtagtgg
     2821 ttacttttga tgatattgat aaatctttgc cagagaacgc ttatccaata atgaaaaaat
     2881 tagacttacc ttttacgcaa ttcattatca cgggaaaagt tggacaaatc attgatggtt
     2941 cacaaatgtc gacttggaaa gaaataaaga aaatgaatga aaatcctttg gttacttcag
     3001 gactacatac gaatgacttg cattatcaag aaaactttga accgatttta tctactaata
     3061 tttcaaaaaa agtagtgcaa aaagattacc aaaaaagtca gaaagcattt gatgagaagt
     3121 tagatcaaaa aggaaaagtt tttgcttatc cttatggagc acaaaataaa gacttagaag
     3181 attatatgct acaagatgga attcaaggaa tattcacact gtctccaggt gtagtgacta
     3241 atgaaacact atatagtaat atccctaggt tgattgttac gaaggataat tggaaaacta
     3301 tcaaacattg gctcttaagt gaaggggcac aatagtaaga gaaaataaga aggagatatt
     3361 catgaaggcg aagaataagt catttaaatt gttaatggtt tgagtttatt gatgtgcttg
     3421 gttggaatta atttatttac aacttcaaat gtatttgctg ctgactatgg aaataaattt
     3481 ataacgggac atgaactgac tgatgatttg ggaaatccga aaacagattt tggtatttat
     3541 gatgatgttc aggctcattg ggattttgat attccagtgg gaagcgttac tcaggggtat
     3601 acaatgagta tcaatgttcc taatttatta accttatcaa aagatgttac tttttaaata
     3661 aaagatgaag ctggaaatat tatcggaacg gcggttgcta atcatcttac gggggtggta
     3721 acttttactt tttcaaaact tgttgaaaat gcaacttcaa atattaaagg tttattttcc
     3781 gtttgggtta attgggatga acaaaaagta gaggaagaca caaaggtagt agttgattgt
     3841 aaagatggag gaacaacaga ggttaacatt ggtccggcaa taggaccgga taaagatgag
     3901 gtactttata aatgggaatg ggttgacgag aatgattcaa ccttaattca ttggcgggtt
     3961 cggatcaatt atgctaaaga aaatattcag aaagctgttt atactgatat tattggtggg
     4021 aatcagaatt tagtttctgg ttcgatttcg gtagctaatg tgacatatag tagtgatgga
     4081 gagaattata atattgatag ctattatcct caggctagta ttttagaaaa tggggtgaac
     4141 ggatttaccg taaatttagg tgatatttca aatacaatta ttgtcgatta ttcaacgagg
     4201 gcaacggatg gcggctttct caacagtata aaaatagagg aggattgacg ggaaaaaata
     4261 ttgaaaaaca ggtagtggaa gttcatacta ctaacaatgg tggaaatgga aatgcaagta
     4321 tgaaactttc tatttctgga gagaaaactt ggattgatga taataatgca cgtggtttaa
     4381 gaccaagttt tattggtatt gagttatatc ggaatgtaga gaaagtttat tcacgagatg
     4441 tgacggctaa aaaaattgga aatattcgtt taccaatttg gataagtatg atgaaagtgg
     4501 gaaactttac gattatgatg taaaagaggt gcctattagt aattatacga gtcaatagga
     4561 ggtgcataat tttataaata caatcatctc tgttaaagta gaaactcctg aaaaaaccga
     4621 ccaatcgatt actgctccta gttcatcctc acaagtaatg tcgacttcct cttcttcaat
     4681 ggaatcagaa acttctgaag agttgcctaa aacgggggat agcccaaagg attttgtcaa
     4741 agagctggga atacttcaat tgatttctgg gggcttggaa tgatttatat taggagaaaa
     4801 tcaaaaattt aattatctga gatgatgtaa aagaaaagga gttatctatt atttgaaact
     4861 cctttttaca tattgtaggc tctcaacttt tatgaaagtg ttgaagactt tttattttta
     4921 tatacagtaa tcgtgatttg acataaacat ccgatgataa agcctaaaac cgccggaaga
     4981 atccaaccca ttcctaggga gaaaaagggg agaaagtctt tagcaaagtt aattattact
     5041 gatatgaaag taattgtgtg aagattggct ggaagagcat tgagtccgtc gataatagcc
     5101 gctaaaagtg taaaagcagt tgtaatctga tagacgagtc tagagtgttt aaaaagcgga
     5161 cttaataagg ttaataaaat aaggataatg gctaagggat ataaaaacat gagtactgga
     5221 actgaaagtt ctataatttt tgtcaaacca atatttgcaa agatgcaagg aagaatactt
     5281 acgatgatta gataaaaacg gtattctttt ttaggaaata attcgacaaa ggtttcagaa
     5341 aaggcagaca ttaaaccaac ggctgttttc aagcaagcga tgatgacaat aagtgctaag
     5401 ataatcatgc cgaaatttcc taagtagtgg ttggaaattt gagcgagagc aattccacca
     5461 ttttcactaa tagcaaattg cccaagactc atagcaccta ggtaagaaag gcaggtgtaa
     5521 atgatagcca ttagtcctac actgataagg ccagctttta tggtttcttt tgcaataatt
     5581 ttaggatttt tcacgccacg ttggcgaata gttgtgatga taatgattcc aaaagctaag
     5641 gcagccaagg catcaagagt attgtaacct tgtgtgaaac ctgtcaaaat aggagatgct
     5701 tgataggctt tgccaatttc tgcttggcta acttttccta atggatgagt gaaagcagtg
     5761 accaaaataa tacctaacaa aaccaaaaag aggggattta aaaattttcc gatataatct
     5821 aagagttttg ttggctttct agacagaaac caggcggttc caaagaaaag gatactaaaa
     5881 agagccaata gtggagcttg gagttcatga cttaaaaaag gtgaaattcc aatttcaaaa
     5941 gaagtggttg ctaagcgagg aagagcgaaa aaggggccaa taacgagata aagtaaaatt
     6001 gtaaaaatat aagcataaat acgattgact cgggaagtta actcaaaaac cccgttactt
     6061 tgagagattc ccagggcgat aattcctaaa aaggggaagc tgactgctgt aattaaaaaa
     6121 ccaaaatttg cttgagaaat agcggctcca gcttcttgac ccatatgtat tggaaaaatt
     6181 aaatttccag caccaaagaa aagtccgaat aacattgacc ctataaagag ataatcttta
     6241 ccaactaatt tttcctccat aaatactcct tataattgat ttgtttgata aataaaataa
     6301 tgaattatta tagcaaaaaa attgtgaatt tacaacacaa ttttatagaa aacatgacga
     6361 ttgattttat taatcctttt aaattatcaa gtaaattcag tgttaaagta aagtttgaag
     6421 aaaatttttt cttttgctta atttagaata aataaaaaag accccgctaa aagatctttt
     6481 atatttaaag attagcttat ttcaaaacat cagttaattc ttctttgtgt tctctgaaat
     6541 atttgacggc ataggggcaa gtggctccta attttaattg ttcgcgtctt gctttttgga
     6601 ttccagcaag aactaatttt tcggctaggc cttgaccgcg atagtcaagt gaaacgccag
     6661 tatgagtgat tattattgaa ttattcatag gcatataggc catttcgcca atgacttctc
     6721 ctttatctga cagaagttca aatagatttt ctctttcaat aatgttcatt agtttttctc
     6781 cttcgccaaa tattttagtg ctccagaagg gcatctattg attactgatt gattggaggc
     6841 gacatcgcca ttatcgggga taatccatgg cttacggcca acttcaaata ctaaaggatt
     6901 tcctctaaca cattcacctg catgttcaca aattgctaca ttgtagtaaa tatccatttt
     6961 tccgccatga tatttacgat aatttttttt taataactct tcttcggtta catcatttcc
     7021 aaatagtttt gaattactca tttacttcct cctgtttaca attgtagttt ttaaaatgaa
     7081 atttgtcaag gtaattagta aaggtagtat acaaattttt gaattatatg aaggaactaa
     7141 gaagggatga aagagatcta cagattataa aaaaggaaat ataatttatg gtggattaat
     7201 caattataaa ttaataaaaa gccctaataa taactaaaag tctttattga cttataaaaa
     7261 atttcagcca aggattttca aagagaaatg gaaatttttg atacacatat aaagtgcgtt
     7321 ttaacctagt tttaaaagat ttactgttaa taaaaataaa atgaaccaaa gaactaacca
     7381 aagcaaaact atacagcatt tactttatcc aaaacctact gtaaaattta tagtaggttt
     7441 tgtagtttaa aatattaaag taaatttaca aataactctt aagtgagata gtctaaataa
     7501 atgaattgat gtgcacccca aaagttagac ttttttggaa agtcaacgaa aaactagaca
     7561 cggagttaag agaatttaag aattatattt ttcaaagtct tttggagact tgtaatcaag
     7621 acctgaatgc atcctttttg tattgtaata ggtctcaatg tatttaaata tttcttgagt
     7681 agcctcagct cttgtctcaa aatgagcatc attaataagc tccctcttta gcgtcttata
     7741 aaaagactcc atcattgcat tgtcataggg atttccttta cgactcatgc tagattgagc
     7801 accgacttga cgaagagtag attgataacg agagcttgta tattgactcc cttgatcagt
     7861 atggacaatc aagccaggct gaggatgttc tttcccacaa gcttgtaaga agcaattcct
     7921 caccagttta tcttgcatcc gtgaagacat tgaccagcct acaatcttac gtgaaaaaac
     7981 gtcgatattc acggctaagt ataaggtgcc ttctttggta gggatatagg tcatgtctcc
     8041 cagccatact ttattaggag ctgttgcttt aaagatctga ttaattaaat tgggtcttga
     8101 aagcgaagct ccttttctgt tgtaatgttt atatttatat cggcttccct tggcataaag
     8161 tcccatcaag tgcatcagtt tcccaacacg tttcgtgttg gtcataatac cagtattatg
     8221 aagtaccttg gtaattctaa ccgcaccata gcgtccctta tgctcatgaa agacagcttt
     8281 tatcttctct gagagaattt ctctctccac ttgttgtttt gaaggacgac gatgcatgta
     8341 ttcatagaaa cctgagcgag aaaccttaag aacttttact gcatgcttaa tttttatctt
     8401 cccatgatgt ttcaagagaa attcaaaacg ttttacttgc ttcgcttcaa gaagacccgg
     8461 aactttttta gaagttcaag ttcctcctga agataacgat tttctttctc taacaattta
     8521 atcttatgtt gagcatcagc tagggctgtc ccattgcctg gaaaagcact ttctccatat
     8581 tcttcaactt cttgaaccca gcgataaaga ctattggcat gaacctcaag ctcttggctg
     8641 acttctttaa cagagtaacc ctcttcaaga atgagtttta ctgcagaatt tttaaattgt
     8701 ttatcgaatt ttcttcttgc cataataaac ctttccacga tttctcttaa ctttgtgtct
     8761 agtttattat aacctttcca ttatgcttgg attttttatt gtttaattcc cttttttgta
     8821 tacaagctcg tattcttaac aaataattgg catatcggct ttaaaaatac tatgtgtttt
     8881 aaagaatctc tcatgagttt gacgccaata acttagatta aaatcaccgt caccttattt
     8941 ttaggcacgt tcggcagtaa ccttatcaaa ggtatctcag tcattaagtt tcatgatagt
     9001 atttactatt ttgatggttt ttgttattat ccaatcgtta aaatgacaaa aacaaataga
     9061 taaatagata aatagataaa tagataaata gataaataga taaatagata aatagataaa
     9121 tagataaata gataatagat aaatagataa atagataaat agataaatag ataaatagat
     9181 aaatagataa atagataaat agataaatag ataaatagat aaatatttat ggggaggaca
     9241 agtgaactta tcatgattaa ttgtaaacga ttgagttctg aatgtttcaa attatgagga
     9301 acaacaggag ttggactatt ctttaaacgc ctcgacgata ccatcactct tcattagcct
     9361 aaaattaaca agttaaaatc attagaataa tctcttttac aaaaaatatt tatttaagtt
     9421 atagttgacg aatatttaat aattttatta atatcttgat tttctagttc ctgaataata
     9481 tagagatagg tttattgagt cttagacata cttgaatgac ctagtcttat aactatactg
     9541 acaatagaaa cattaacaaa tctaaaacag tcttaattct atcttgagaa agtattggta
     9601 ataatattat tgtcgataac gcgagcataa taaacggctc tgattaaatt ctgaagtttg
     9661 ttagatacaa tgatttcgtt cgaaggaact acaaaataaa ttataaggag gcactcaaaa
     9721 tgagtacaaa agattttaac ttggatttgg tatctgtttc gaagaaagat tcaggtgcat
     9781 caccacgcat tacaagtatt tcgctatgta cacccggttg taaaacagga gctctgatgg
     9841 gttgtaacat gaaaacagca acttgtaatt gtagtattca cgtaagcaaa taaccaaatc
     9901 aaaggatagt attttgttag ttcagacatg gatactatcc tatttttata agttatttag
     9961 ggttgctaaa tagcttataa aaataaagag aggaaaaaac atgataaaaa gttcatttaa
    10021 agctcaaccg tttttagtaa gaaatacaat tttatctcca aacgataaac ggagttttac
    10081 tgaatatact caagtcattg agactgtaag taaaaataaa gtttttttgg aacagttact
    10141 actagctaat cctaaactct atgatgttat gcagaaatat aatgctggtc tgttaaagaa
    10201 gaaaagggtt aaaaaattat ttgaatctat ttacaagtat tataagagaa gttatttacg
    10261 atcaactcca tttggattat ttagtgaaac ttcaattggt gttttttcga aaagttcaca
    10321 gtacaagtta atgggaaaga ctacaaaggg tataagattg gatactcagt ggttgattcg
    10381 cctagttcat aaaatggaag tagatttctc aaaaaagtta tcatttacta gaaataatgc
    10441 aaattataag tttggagatc gagtttttca agtttatacc ataaatagta gtgagcttga
    10501 agaagtaaat attaaatata cgaatgttta tcaaattatt tctgaatttt gtgagaatga
    10561 ctatcaaaaa tatgaagata tttgtgaaac tgtaacgctt tgctatggag acgaatatag
    10621 agaactatcg gaacaatatc ttggcagtct gatagttaat cattatttga tctctaattt
    10681 acaaaaagat ttgttgtcag atttttcttg gaacactttt ttgactaaag ttgaagcaat
    10741 agatgaagat aaaaaatata taattcctct gaaaaaagtt caaaagttta ttcaagaata
    10801 ctcagaaata gaaattggtg aaggtattga gaaactgaaa gaaatatatc aggaaatgtc
    10861 acaaattctt gagaatgata attatattca aattgattta attagtgata gtgaaataaa
    10921 ttttgatgtt aaacaaaagc aacaattaga acatttagct gagtttttag gaaatacgac
    10981 aaaatctgta agaagaacat atttggatga ctataaggat aaatttatcg aaaaatatgg
    11041 tgtagatcaa gaagtacaaa taacagaatt atttgattct acatttggca taggagctcc
    11101 atataattat aatcatcctc gaaatgactt ttatgagtcc gaaccgagta ctctatacta
    11161 ttcagaagag gagagagaaa agtacctcag catgtatgta gaagccgtta aaaatcataa
    11221 tgtaattaat cttgacgact tagagtctca ttatcaaaaa atggacttag aaaagaaaag
    11281 tgaacttcaa gggttagaat tatttttgaa tttggcaaag gagtatgaaa aagatatttt
    11341 tattttaggg gatatcgttg gaaataataa tttgggaggg gcatcaggta gattttctgc
    11401 actctctccg gagttaacaa gttatcatag aacgatagta gattctgtcg aaagagaaaa
    11461 tgagaataaa gaaattacat cgtgtgaaat agtatttctt ccagaaaata tcagacatgc
    11521 taacgttatg catacatcaa ttatgaggag gaaagtactt ccatttttta caagtacaag
    11581 tcacaatgaa gttctgttaa ctaatatcta tattggaata gacgaaaaag aaaaatttta
    11641 tgcacgagac atttcaactc aagaggtatt gaaattctac attacaagca tgtacaataa
    11701 aacgttattc agtaatgagc taagatttct ttacgaaatt tcattagatg acaagtttgg
    11761 taatttacct tgggaactta tttacagaga ctttgattat attccacgtt tagtatttga
    11821 cgaaatagta atatctcctg ctaaatggaa aatttgggga agggatgtaa atagtaagat
    11881 gacaataaga gaacttattc aaagcaaaga aattcccaaa gagttttata ttgtcaatgg
    11941 agataataaa gtttatttat cacaggaaaa cccattggat atggaaattt tagagtcggc
    12001 gataaagaag agctcaaaaa gaaaagattt tatagagcta caagaatatt ttgaagatga
    12061 aaatatcata aataaaggac aaaaggggag agttgccgat gttgtagtgc cttttattag
    12121 aacgagagca ttaggtaatg aaggaagagc atttataaga gagaaaagag tttcggttga
    12181 acggcgtgaa aaattgccct ttaacgagtg gctttatctc aagttgtaca tttctataaa
    12241 tcgtcaaaat gaatttttac tgtcgtatct tccagatatt cagaaaatag tagcaaacct
    12301 gggtggaaat ctattcttcc taagatatac tgatcctaaa ccacatatta gattgcgtat
    12361 aaaatgttca gatttatttt tagcttacgg atctattctt gaaatcttaa aaaggagtcg
    12421 gaaaaatagg ataatgtcaa cttttgatat ttctatttat gatcaagaag tagaaagata
    12481 tggtggattt gatactttag agttatccga agcaatattt tgtgccgatt ctaaaattat
    12541 tccaaatttg cttacattga taaaagatac taataatgat tggaaagtcg atgatgtatc
    12601 aatcttggtg aattatttat atctgaaatg cttctttcag aatgataaca aaaagattct
    12661 taattttttg aatttagtta gtcctaaaaa ggttaaagaa aatgtcaatg aaaagattga
    12721 acattatctt aagcttctga aagttaataa tctaggtgac caaatttttt atgacaagaa
    12781 ttttaaagaa ttaaagcatg ccataaaaaa tttattttta aaaatgatag ctcaagattt
    12841 tgaacttcag aaagtttatt caattattga cagtatcatt catgtccata ataaccgact
    12901 aattggtatt gaacgagata aagagaaatt aatttattac acacttcaaa ggttgtttgt
    12961 ttcggaagaa tacatgaaat gaggactaat agatggatga agtgaaagaa ttcacatcaa
    13021 aacaattttt taatacttta cttactcttc caagcacctt gaagttaatt tttcagttgg
    13081 aaaaacgtta tgcaatttat ttaattgtgc taaatgctat cacagctttt gttccgttgg
    13141 ctagtctttt tatttatcaa gatttaataa actctgtgct aggttcaggg agacatctta
    13201 tcaatattat tatcatctat tttattgttc aagtgataac aacagttctg ggacagctgg
    13261 aaagttatgt tagtggaaaa tttgatatgc gactttctta cagtatcaat atgcgcctca
    13321 tgaggactac ctcatctctt gaattaagtg attatgagca ggctgatatg tataatatca
    13381 tagaaaaagt tactcaagac agcacttaca agccttttca gctatttaat gctatcattg
    13441 ttgtgctttc atcgtttatc tcattgttat ctagtctatt ttttattgga acatggaaca
    13501 ttggggtagc aattttactc cttattgttc cagtattatc tttggtactt tttctcagag
    13561 tgggacaatt agagttttta atccagtggc agagagcaag ttctgaaaga gaaacatggt
    13621 atattgtata tttattgact catgattttt catttaaaga aatcaagtta aataatatta
    13681 gcaattactt cattcataaa tttggaaaat taaagaaagg atttatcaac caagatttag
    13741 ctattgctcg taagaagaca tatttcaata tttttcttga tttcattttg aatttgataa
    13801 atattcttac gatatttgct atgatccttt cggtaagagc aggaaaactt cttataggta
    13861 atttggtaag tctcatacaa gctatttcta aaatcaatac ttattctcaa acaatgattc
    13921 aaaatattta catcatttat aatactagtt tgtttatgga acaacttttt gagtttttaa
    13981 agagagaaag tgtagttcac aaaaaaatag aagatactga aatatgcaat caacatatag
    14041 gagctgttaa agtaattaat ttatcatatg tttaccctaa ttcgaatgcc tttgcactaa
    14101 agaatatcaa tttatccttt gaaaaaggag aattaactgc tattgtagga aaaaatggtt
    14161 cagggaaaag tacactagta aagataattt caggattata tcaaccaact atgggaataa
    14221 tccaatacga caaaatgaga agtagtttga tgcctgagga gttttatcag aaaaacatat
    14281 cggtgctgtt ccaagatttt gtgaagtatg agttaacgat aagagagaat ataggattga
    14341 gtgatttgtc ttctcaatgg gaagatgaga aaattattaa agtactagat aatttaggac
    14401 tcgatttttt gaaaactaat aatcaatatg tacttgatac gcagttaggg aattggtttc
    14461 aagaagggcg tcaactttca ggaggtcagt ggcaaaaaat tgcattagca aggacattct
    14521 ttaagaaagc ttcaatttat attttagatg aaccaagtgc tgcactcgat cctgtagctg
    14581 aaaaagaaat atttgattat tttgttgctc tttcggaaaa taatatttca attttcattt
    14641 ctcatagttt gaatgctgcc agaaaagcaa ataaaatcgt ggttatgaaa gatggacagg
    14701 tcgaagatgt tggaagtcat gatgtccttc tgagaagatg tcaatactat caagaacttt
    14761 attattcaga gcaatatgag gataatgatg aataaaaaaa atataaaaag aaatgttgaa
    14821 aaaattattg ctcaatggga tgagagaact agaaaaaata aagaaaactt cgatttcgga
    14881 gagttgactc tctctacagg attgcctggt ataattttaa tgttagcgga gttaaaaaat
    14941 aaagataact caaagatata tcagaaaaag atagacaatt atattgaata tattgttagc
    15001 aaactttcaa catatgggct tttaacagga tcactttatt cgggagcagc tggcattgca
    15061 ttaagtatcc tacatttacg agaagatgac gaaaaatata agaatcttct tgatagccta
    15121 aatagatata tcgaatattt cgtcagagaa aaaattgaag gatttaattt ggaaaacatt
    15181 actcctcctg attatgacgt gattgaaggt ttatctggga tactttccta tctattatta
    15241 atcaacgacg agcaatatga tgatttgaaa atactcatta tcaatttttt atcaaatctg
    15301 actaaagaaa acaaaggact aatatcgctt tacatcaaat cggagaatca gatgtctcaa
    15361 tcagaaagtg agatgtatcc actaggctgt ttgaatatgg gattagcaca tggacttgct
    15421 ggagtgggct gtatcttagc ttatgcccac ataaaaggat atagtaatga agcctcgttg
    15481 tcagctttgc aaaaaattat ttttatttat gaaaagtttg aacttgaaag gaaaaaacag
    15541 tttctatgga aagatggact tgtagcagat gaattaaaaa aagagaaagt aattagggaa
    15601 gcaagtttca ttagagatgc atggtgctat ggaggtccag gtattagtct gctatactta
    15661 tacggaggat tagcactgga taatgactat tttgtagata aagcagaaaa aatattagag
    15721 tcagctatgc aaaggaaact tggtattgat tcatatatga tttgccatgg ctattctggt
    15781 ttaatagaaa tttgttcttt atttaagcgg ctattaaata caaaaaagtt tgattcatac
    15841 atggaagaat ttaatgttaa tagtgagcaa attcttgaag aatacggaga tgaaagtggc
    15901 acgggttttc ttgaaggaat aagtggctgt atactggtat tatcgaaatt tgaatattca
    15961 atcaatttta cttattggag acaagcactg ttactttttg acgatttttt gaaaggaggg
    16021 aagaggaaat gagaagatat ttaatactta ttgtggcctt aatagggata acaggtttat
    16081 cagggtgtta tcaaacaagt cataaaaagg tgaggtttga cgaaggaagt tatactaatt
    16141 ttatttatga taatacatcg tatttcgtaa ctgataagga gattcctcag gagaacgcta
    16201 acaattccaa agtaaaattt tataagctgt tgattgttga catgaaaagt gagaaacttt
    16261 tatcaagtag caacaaaaat agtgtgactt tggtcttaaa taatatttat gaggcttctg
    16321 acaagtcgct atgtatgggt attaacgaca gatactataa gatacttcca gaaagtgata
    16381 agggggcggt caaagctttg agattacaaa actttgatgt gacaagcgat atttctgatg
    16441 ataattttgt tattgataaa aatgattcac gaaaaattga ctatatggga aatatttaca
    16501 gtatatcgga caccaccgta tctgatgaag aattgggaga atatcaggat gttttagctg
    16561 aagtacgtgt gtttgattca gttagtggca aaagtatccc gaggtctgaa tgggggagaa
    16621 ttgataagga tggttcaaat tccaaacaga gtaggacgga atgggattat ggcgaaatcc
    16681 attctattag aggaaaatct cttactgaag catttgccgt tgagataaat tatgatttta
    16741 agcttgcaac gaaggtagga aactagagtg aaaaaaatac taggtttcct ttttatcgtt
    16801 tgttcgttgg gtttatcagc aactgtgcat ggggagacaa caaattcaca acagttactc
    16861 tcaaataata ttaatacgga attaattaat cataattcta atgcaatttt atcttcaaca
    16921 gagggatcaa cgactgattc gattaatcta ggggcgcagt cacctgcagt aaaatcgaca
    16981 acaaggactg aattggatgt aactggtgct gctaaaactt tattacagac atcagctgtt
    17041 caaaaagaaa tgaaagtttc gttgcaagaa actcaagtta gttctgaatt cagtaagaga
    17101 gatagcgtta caaataaaga agcagttcca gtatctaagg atgagctact tgagcaaagt
    17161 gaagtagtcg tttcaacatc atcgattcaa aaaaataaaa tcctcgataa taagaagaat
    17221 agagctaact tcgttacttc ctctcagctt attaaggaaa aaccatcaaa ttctaaagat
    17281 gcatctggtg taattgataa ttctgcttct cctctatctt atcgtaaagc taaggaagtg
    17341 gtatctctta gacaaccttt aaaaaatcaa aaagtagagg cacaacctct attgataagt
    17401 aattcttctg aaaagaaagc aagtgtttat acaaattcac atgatttttg ggattatcag
    17461 tgggatatga aatatgtgac aaataatgga gaaagctatg cgctctacca gccctcaaag
    17521 aaaatttctg ttggaattat tgattcagga atcatggaag aacatcctga tttgtcaaat
    17581 agtttaggaa attattttaa aaatcttgtt cctaagggag ggtttgataa tgaagaacct
    17641 gatgaaactg gaaatccaag tgatattgtc gacaaaatgg gacacgggac ggaagtcgca
    17701 ggtcagatta cagcaaatgg taatatttta ggagtagcac cagggattac tgtaaatata
    17761 tacagagtat ttggtgaaaa tctttcgaaa tcggaatggg tagctagagc aataagaaga
    17821 gctgcggatg atgggaacaa ggtcatcaat ataagtgctg gacagtatct tatgatttca
    17881 ggatcatatg atgatggaac aaatgattat caagagtatc ttaattataa gtcagcaata
    17941 aattatgcaa cagcaaaagg aagtattgtt gtcgcagctc ttggtaatga tagtttaaac
    18001 atacaagata accaaacaat gataaacttt cttaagcgtt tcagaagtat aaaggttcct
    18061 ggaaaagttg tagatgcacc gagtgtattt gaggatgtaa tagccgtagg tggaatagat
    18121 ggttatggta atatttctga ttttagtaat attggagcgg atgcaattta tgctcctgct
    18181 ggcacaacgg ccaattttaa aaaatatggg caagataaat ttgtcagtca gggttattat
    18241 ttgaaagatt ggctttttac aactactaat actggctggt accaatatgt ttatggcaac
    18301 tcatttgcta ctcctaaagt atctggggca ctggcattag tagttgataa atatggaata
    18361 aagaatccta accaactaaa aaggtttctt ctaatgaatt ctccagaagt taatgggaat
    18421 agagtattga atattgttga tttattgaat gggaaaaata aagcttttag cttagataca
    18481 gataaaggtc aggatgatgc tattaaccat aaatcgatgg agaatcttaa agagtctagg
    18541 gatacaatga aacaggaaca agataaagaa attcaaagaa atacaaataa caatttttct
    18601 atcaaaaatg attttcataa catttcaaaa gaagtaattt cagttgatta taatattaat
    18661 caaaaaatgg ctaataatcg aaattcgaga ggtactgttt ctgtacgaag tcaagaaatt
    18721 ttacctgtta ctggagatgg agaagatttt ttaccggctt taggtatagt gtgtatctca
    18781 atccttggta tattgaaaag aaagactaaa aattgataga ttatatttct tcagaatgaa
    18841 tggtataatg aagtaatgag tactaaacaa tcggaggtaa agtggtgtat aaaattttaa
    18901 tagttgatga tgatcaggaa attttaaaat taatgaagac agcattagaa atgagaaact
    18961 atgaagttgc gacgcatcaa aacatttcac ttcccttgga tattactgat tttcagggat
    19021 ttgatttgat tttgttagat atcatgatgt caaatattga agggacagaa atttgtaaaa
    19081 ggattcgcag agaaatatca attccaatta tctttgttag tgcgaaagat acagaagagg
    19141 atattataaa cggcttaggt attggtgggg atgactatat tactaagcct tttagcctta
    19201 aacagttggt tgcaaaagtg gaagcaaata taaagcgaga ggaacgcaat aaacatgcag
    19261 ttcatgtttt ttcagagatt cgtagagatt taggaccaat tacattttat ttagaagaaa
    19321 ggcgagtctg tgtcaatggt caaacaattc cactgacttg tcgtgaatac gatattcttg
    19381 aattactatc acaacgaact tctaaagttt atacgagaga ggatatttat gatgacgtat
    19441 atgatgaata ttctaatgca ctttttcggt caatctcgga gtatatttat cagattagga
    19501 gtaagtttgc accatacgat attaatccga taaaaacggt tcggggactt gggtatcagt
    19561 ggcatgggta aaaaatattc aatgcgtcga cggatatggc aagctgtcat tgaaattatc
    19621 ataggtactt gtctacttat cctgttgtta ctgggcttga ctttctttct acgacaaatt
    19681 ggacaaatca gtggttcaga aactattcgt ttatctttag attcagataa tttaactatt
    19741 tctgatatcg aacgtgatat gaaacactac ccatatgatt atattatttt tgacaatgat
    19801 acaagtaaaa ttttgggagg acattatgtc aagtcggatg tacctagttt tgtagcttca
    19861 aaacagtctt cacataatat tacagaagga gaaattactt atacttattc aagcaataag
    19921 catttttcag ttgttttaag acaaaacagt atgcctgaat ttacaaatca tacgcttcgt
    19981 tcaatttctt ataatcaatt tacttacctt ttcttttttc ttggtgaaat aatactcatt
    20041 attttttctg tctatcatct cattagagaa ttttctaaga attttcaagc cgttcaaaag
    20101 attgcattga agatggggga aataactact tttcctgaac aagaggaatc aaaaattatt
    20161 gaatttgatc aggttctgaa taacttatat tcgaaaagta aggagttagc tttccttatt
    20221 gaagcggagc gtcatgaaaa acatgattta tccttccagg ttgctgcact ttcacatgat
    20281 gttaagacac ctttaacagt attaaaagga aatattgaac tgctagagat gactgaagta
    20341 aatgaacaac aagctgattt tattgagtca atgaaaaata gtttgactgt ttttgacaag
    20401 tattttaaca caatgattag ttatacaaaa cttttgaatg atgaaaatga ttacaaagcg
    20461 agaatctccc tggaggattt tttgatagat ttatcagttg agttggaaga gttgtcaaca
    20521 acttatcaag tggattatca gctagttaaa aaaacagatt taaccacttt ttacggaaat
    20581 acattagctt taagtcgagc acttatcaat atctttgtta atgcctgtca gtatgctaaa
    20641 gagggtgaaa aaatagtcag tttgagtatt tatgatgatg aaaaatatct ctattttgaa
    20701 atctggaata atggtcatcc tttttctgaa caagcaaaaa aaaatgctgg aaaactattt
    20761 ttcacagaag atactggacg tagtgggaaa cactatggga ttggactatc ttttgctcaa
    20821 ggtgtagctt taaaacatca aggaaactta attctcagta atcctcaaaa aggtggggca
    20881 gaagttatcc taaaaataaa aaagtaattt agtaatctct aaggattact ttttttgttt
    20941 ctgaatagat tctgaaaatt gttttatata ctttttttaa acataaaata aagtgaggaa
    21001 atataatgca ggtaaaaatt caaaatcttt ctaaaacata taaagaaaag caggtgctac
    21061 aagatatcag ttttgatatt aaatctggaa cagtctgtgg tttattagga gttaacggtg
    21121 caggaaaatc aactttgatg aaaattttgt ttggtttaat ttctgcagat actggaaaaa
    21181 ttttttttga tggacaagaa aagacaaata atcaacttgg agccttaatc gaggctccag
    21241 caatatatat gaatttatct gctttcgata atcttaaaac taaggctttg ctttttggaa
    21301 tttcagataa gagaattcat gaaactctag aagtgattgg tttggcagaa acaggaaaga
    21361 aaagagcagg aaaattctct ttagggatga aacaacgttt gggaattggt atggctattc
    21421 ttacagaacc tcaattttta attcttgatg aacctactaa tggtttggat cctgatggta
    21481 ttgcggagtt gttaaactta atcttaaaac ttaaagctaa aggtgtgaca atcttgattt
    21541 ctagtcatca gttgcacgaa ataagtaaag tagctagtca aattattatt ttgaacaaag
    21601 gtaagattcg ttataatcat gcgaacaata aagaagacga cattgaacag ttattcttta
    21661 agattgtgca tggaggaatg tgatatgaaa agaataatag catcagaagc aataaaatta
    21721 aaaaaatcag gaactcttag attggtatta attatccctt ttgtgactct atttatagca
    21781 tttcttatgg gtggaataca gatttttagt gttttttcaa tttattggtg ggaaactggt
    21841 tttttattcc ttttgatgag tttgcttttt ctttatgata taaaatcaga ggagcaagct
    21901 ggaaattttc aaaatgtgaa atggaaaaag ctgagttgga aaattcattt ggccaaaatg
    21961 ttgttgattt ggctaagagg tatactagcg agcatagtct tgattatttt gctttatttg
    22021 gttgcttttg tgtttcaagg tattgtagtg gtggatttta tgaaagtaag tgtggcattg
    22081 attgctatat tactagcagc ttcttggaat ttacccttta tatacttgat tttcaagtgg
    22141 attaatactt acgtattgtt agctgcgaat accttgattt gtttaattgt tgcccctttt
    22201 gttgcacaaa ctccagtatg gttcttgcta ccatacactt atcactataa agttacagaa
    22261 agtttgttaa atatcaaacc atcaggagat ttgttaacag ggaagataaa tttcagtatt
    22321 tgggaagttt tattaccatt tggactttcc atagttgtaa cgataggagt ttcgtattta
    22381 cttaaaggag tgatagaaca tgataagaag tgaatgtctc aaattaaaaa atagcttagg
    22441 gttttattta gtttttctct ttactttatt agagctttta acggttccta tttatttagc
    22501 ttttggaaga agtcatgttt caatgactga tttgtcgctc atgatttttt tgttttttcc
    22561 gttactggtt acaattttgt ctattctaat ctttgaacag gagagtctgg ccaatcgttt
    22621 ccaagaaata aatgtaaata aaaaaagtag cagaatttgg ttatcaaagc taatagtagt
    22681 ggatttcctt ttgttctttc catcagcaat gatctggata attacgggag tttcacaggc
    22741 agtagggcaa caaggaatga tgatcgcaac agctagctgg ttgatggcaa tttttcttaa
    22801 tcattttcat cttttattga cctttataat caatcgagga gggagcatga ttatcgcgat
    22861 tattgaaata ttactcatta tttttgccag taataaagtt ttattagcag cttattggtg
    22921 tcctattgct ttacctgtta attttatgat aaatgggcgg tgtgcttatc tgatagctgc
    22981 cgtagggtgg attgttttat ccacaataat tcttgtagca ttatctaaaa aaaagattag
    23041 ataaagtatt ttttcttatg gtaattcgac ctaatatgtt tttgctattt atctcttatt
    23101 tctgtctata gtaatttatt caaagtacct ttagactcat aagtttgaat aaaatttcta
    23161 tcaatatgtg acagttctta ctctaagaat aatgtttccg tcgttagttt tcttttctca
    23221 gtaatttttt ataaagtggt ttcctatcga cttacacttt ttcttttgga gttattggtg
    23281 tcaagctcat gagagattct ttaaagcata taacattttt aaactgatat gccagttatt
    23341 tgtgaagaat atgagtttct atataaaaga gaaaattaaa caatgaaaaa tccaagtata
    23401 aatacttgga tttttcatta tttttgatag acatataaag tgcattttaa cctagaatta
    23461 aaagatgtat cgttgataat aataaaatga accaaagcaa aactgacgtt aagtcaattt
    23521 attagagtca aaaacgtata attttaatgt atttatttta agtgatttct ttttcaaatt
    23581 gattaggcgt aagataccct aaactttgat ggattcgttt tgaattataa aaggcttcaa
    23641 tataccagaa aatactctga taggcttctt caaagttctt atatttaaat tgatagaccc
    23701 actctctttt taaatgtcca tgccaagatt caagactggc attatgataa ggatagccct
    23761 tacgactgaa ggagtgagtc attccagagt tttttattgt ctcttcatac tcatgactcg
    23821 tatactgact tccttggtca gaatgaagca tcacagcttc tggataattt tgtgattcca
    23881 ttgccttatt caaagtcctt tgcactaatt ctacagtcat tcgctttcct aaatcccaag
    23941 caatgacttt tttagtataa cgatccataa tggttgagag ataaacccag ccttgttgag
    24001 taggaatata agtaatatca gttgcccaaa ccttatttat ctttttaggc ttattttgtt
    24061 aataccatca cttacggagt gtccgggttt aaatttttta aggacgacgg acttgagctg
    24121 aagttgtttc ataatttttt gtacgagctt atccctactt tttccccttg attgagtaag
    24181 aggtgatgaa tcttaggtgc cccatagatt ccccgattcg ccttgaaaag ttggtcaatc
    24241 ttcagtgcca agtgctgtct tcttaattga gttttggatg gccgtcgatt gattctctca
    24301 taataacttg cttcaggaac accaagcagt tggcaactga gtctgacatt gagtgctaaa
    24361 gttttaatcg tttgagacat atccgcagca ctcacatctt tttctcggcg aatatggtca
    24421 atactttttt aagatgtctc gttcttcctt aactttagcc agctgtcttt ttaattctag
    24481 aaaatcatct ttagagactg agctttcatt agacttagaa tagaggtcga tccatttata
    24541 aatcgttgca ggagccacgc cgtattcttt agaaagctgt gtgacggatt gcccagaatg
    24601 atagaagtcg agaagggtgt ctttaaattc ttgtgagtag cgtttttgca tgtttttatc
    24661 ctttgtctaa attatacaat agtgactcta agaattaagg atagcatcac agtgtctttt
    24721 tgaagaagta aaatatattt ttaatctata ccataatgta gctgaacagg aagttgatat
    24781 gtaatgtcaa tgttatctcc atcaattttt cgtatgatta aatcaactaa gagttccgct
    24841 aaatcattta ttggttgctt tatcgttgtt aggttaggat agtagttttc tataaattca
    24901 gttccatcaa aacctaccac attaagtgat ttttttaaat ttgaggcgag atcttttact
    24961 aatatagctg ttaaatcatc tgtacaaaat acaccatcaa aatcgttgtt ttctagtatt
    25021 tttttgatct caactttttt gcgaagaaga gtccattgag aaggaatttt tattatatga
    25081 ggctttaatt gatttctttc tagctcaagc agatatccat cacgccttaa atatgtagga
    25141 gaattggtat tatcgttccc agtaaatatg gcgatttttt tacttccaga gttaatcaaa
    25201 gctttagtag ctaggattcc tccctcaaaa ttatcagagc taacaacagt cgtttcaggg
    25261 gttaataaac ggtcaaaagc aacaataggt gcttcaattg ctatataatc atgtgctttt
    25321 aaattatgac tcccataaat aattccatca acttggttag aaagtaataa ggcaagatag
    25381 tctcgctctt tttgttcatc atgttctgtt gttgctaaca tagctttgta acctcgtttg
    25441 aaaagagctt gctcaatttt ttcaatcaat tctgcataaa aaatattttt tatagttgga
    25501 aatactagcc caattaattt taaagacttt ccttgcaaag aacgtgcggc tgcgtttgga
    25561 atataatgca agtcttgcat tgctttttct acttttgata ttgttgcgtc actcaaatat
    25621 cctttacgat ttataacacg cgaaactgtc gttacactaa ccccagcttt atttgcaaca
    25681 tcttcaagtt taatcacttt tttagctccc ataattttat ttttatcgga ttttgacttc
    25741 taatcgaata ctgattctta tttggaaata cacgacctga taatactttt tcaccatcat
    25801 taataaaaat ttcaaaaatt gattgatcaa taaatacatt cattttttct attttaacat
    25861 gtgccaaacg tttttcataa tttcttataa gtgtaatagt attattttct ttatctatct
    25921 caactttaag tgcactatcc cctttttcat ttgtcattaa agatagaagt gtagaggttt
    25981 gctgacgaaa atcgacctca agttcataag agttagatgt aataatgtta tt
//
