LOCUS       NZ_CP065920            21544 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Staphylococcus pseudintermedius strain SP_11306-1A chromosome,
            complete genome.
ACCESSION   NZ_CP065920
VERSION     NZ_CP065920.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus pseudintermedius
  ORGANISM  Staphylococcus pseudintermedius
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus; Staphylococcus intermedius group.
REFERENCE   1  (bases 1 to 2605463)
  AUTHORS   Byukusenge,M., Banovich,F., Li,L., Kuchipudi,S.V., Jayarao,B.M. and
            Naikare,H.K.
  TITLE     Complete genome sequences of Staphylococcus pseudintermedius strains
            isolated from canine superficial pyoderma lesions in Georgia, USA
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2605463)
  AUTHORS   Byukusenge,M., Banovich,F., Li,L., Kuchipudi,S.V., Jayarao,B.M. and
            Naikare,H.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2020) Veterinary and Biomedical Sciences,
            Pennsylvania State University, Wiley Ln, University Park, PA 16802,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.12
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 233x
            Sequencing Technology             :: Illumina & Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016126755.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 13:13:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,469
            CDSs (total)                      :: 2,387
            Genes (coding)                    :: 2,345
            CDSs (with protein)               :: 2,345
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 42
            CDSs (without protein)            :: 42
            Pseudo Genes (ambiguous residues) :: 0 of 42
            Pseudo Genes (frameshifted)       :: 13 of 42
            Pseudo Genes (incomplete)         :: 29 of 42
            Pseudo Genes (internal stop)      :: 14 of 42
            Pseudo Genes (multiple problems)  :: 12 of 42
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:44:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2432259
            Orig. end                         :: 2453803
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP065920.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21544
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /region_number="10"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     cand_cluster    1..21544
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21544
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11544](+)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11544
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     misc_feature    complement(359..374)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.51"
                     /tool="antismash"
     misc_feature    938..957
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 23.74"
                     /tool="antismash"
     misc_feature    941..955
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 22.46"
                     /tool="antismash"
     misc_feature    1001..1016
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.22"
                     /tool="antismash"
     misc_feature    complement(1251..1265)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 19.72"
                     /tool="antismash"
     misc_feature    complement(1879..1893)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.25"
                     /tool="antismash"
     misc_feature    2118..2132
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 19.43"
                     /tool="antismash"
     misc_feature    2159..2172
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.06"
                     /tool="antismash"
     misc_feature    complement(2297..2310)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.72"
                     /tool="antismash"
     gene            2709..3587
                     /locus_tag="JC281_RS11545"
                     /old_locus_tag="JC281_11545"
     CDS             2709..3587
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614835.1"
                     /locus_tag="JC281_RS11545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11545"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_014614835.1"
                     /transl_table=11
                     /translation="MELKQLKYFVEVAKREHISEAALELNVAQSAISRHIHNLENELET
                     SLFYRRGRNVFLTAEGKQLLEYAQQILEQVDLTLSQFQTQVQQQQSVFTIGYVDGSIGQ
                     ILPQVLQTIENELSLSLIPTLLDEQETLQALRAQEIDFALTTVTTTDPTFEIVPLVEET
                     YVLYGDLHAPMMNVPNPPLSHILKQPLYLLEPIPTDFKTYLITHADKPVRVLNQEQFAR
                     FILRNQKGFVLAPTYVNLYSQNQQWKKISLSHTDFKKTLRLIYRRDLQKPLRDEVIQII
                     MTHIQQRSVYH"
     gene            3600..4709
                     /locus_tag="JC281_RS11550"
                     /old_locus_tag="JC281_11550"
     CDS             3600..4709
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614836.1"
                     /locus_tag="JC281_RS11550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11550"
                     /product="YibE/F family protein"
                     /protein_id="WP_140223701.1"
                     /transl_table=11
                     /translation="MKQLSKKINTIVIVVSIIVAICAIVFTRLNSSFYHIPLGEVTKIE
                     SHHQEKSVDEQHNQDVKYKDVLQVKLLNTKQQGDTLHVEHRYNASKTEEQAYQPGDKVL
                     LHKGKNQKDTYIIEKKRDTVLVTVISAFFIALLIVGQRIGLQSILSLVINAFAILLAIS
                     LYHAYPQLNLFLLMSLAVMIATILTLWLVIGWSMRTIVTIVSTLLGTFICIFIAWSVIG
                     LTHGQGIKYETMSFLTIQPRTVFLTSVMVGTLGAVMDVAITISSGMYEVLQRSPHISMQ
                     RWVLAGRNIGRDIMGTMTNILLFSYLAGSLPMLLLYLKNGNTLTYSISMNWSLEISRAI
                     TGGIGIVLTIPLTIFLMRLWLSLRGGATR"
     gene            4706..5479
                     /locus_tag="JC281_RS11555"
                     /old_locus_tag="JC281_11555"
     CDS             4706..5479
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020220087.1"
                     /locus_tag="JC281_RS11555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11555"
                     /product="YibE/F family protein"
                     /protein_id="WP_014614837.1"
                     /transl_table=11
                     /translation="MNAIVILGLILFILMLIFGGKTGLVSFLTLFLNFIILFITVLAIV
                     FGAPIYVVTFIFCIIVSMVNLFLLNRFNTKTLAAFIASTVTTLLMIVAVYLSVHWGHLQ
                     GFTQEEQDETYIFSLNIGIDMEQFMIFTVLLAVIAAVIDLAITISSPVFELHETNPSLS
                     ERELFHSGMRVGREILATSANTIYLALIGGSMTIVFWFFNLHYSFGHMLNAKLFTQEVI
                     TIALGGVAIAVCIPITAMITAWLVKHRHQLPFHLD"
     gene            5528..7789
                     /locus_tag="JC281_RS11560"
                     /old_locus_tag="JC281_11560"
     CDS             5528..7789
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019166373.1"
                     /locus_tag="JC281_RS11560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11560"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_131112596.1"
                     /transl_table=11
                     /translation="MTAIHIHGARQNNLKNIDVSIPKHQLTVVTGRSGSGKSSLVFNTI
                     AAESERLLNETYSSYIQHQLTQYEKPDVDHIENLPVAMVINQKRLGGNSRSTVGTISDI
                     YASVRLLWSRIGTPFVGYSDVFSFNNPNGMCEHCQGLGYVEDIDLNELLDFDKSLNEGA
                     IRFPSFKPDSWRGKRYRYSGLFDNDKKLKDYTKEELDTFLYTEPTRLKNPPSEWPKTAK
                     FEGLIHRFRRSFLINDNFEKKRFLKDVERVVTKQTCPVCHGQRLNQKVLSCKIHGLNIA
                     DFTALTIEETLPFLEQIDSDKATYIIEPLKAQLQALNDIGLNYLTLARETTTLSGGESQ
                     RIKLIRHLNSPLTDLVYIIDEPSVGLHPADIEKINEIMLNIRDKGNTVIIVEHDPDVIK
                     IADHVIDIGPGAGKHGGHITFEGSYAQLKQSDTDTARALTRQHHLKQSAIRDNQAWLHL
                     EHLQHNNLQDVSVAIPKNAQTVVTGVAGSGKSSLIKGGFAKHEDAILIDQKGVHTSNRS
                     NLLTYTGIFDDIREFFSKATGLKKSMFSYNSDGACPNCNGKGVLKTELAFMPDFSQVCE
                     VCGGTRYRPEVLETKVDGYSIADVLALTVEEGLSLFQTHDAIAQTLSALQSTGLGYMTL
                     GQSLDTLSGGEIQRLKLTRYMIEPVTEKIFIFDEPTTGLHEDDIPILQARFDQLIEEGH
                     TVILIEHNITMMTRADWLIDVGPGAGNQGGRILYSGPPAGLKNVAESRTAPHLFGSLSE
                     "
     gene            complement(7856..8176)
                     /locus_tag="JC281_RS11565"
                     /old_locus_tag="JC281_11565"
     CDS             complement(7856..8176)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025126.4"
                     /locus_tag="JC281_RS11565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11565"
                     /product="transposase"
                     /protein_id="WP_070407722.1"
                     /transl_table=11
                     /translation="MKQSTKSNTNKSLFKNLTWDYFKAFINKQLSDPKTKHIYQKRKID
                     VESTFVNLKANLGFQRLSVRTQSKVECELGIALMAVNIRKLAKISARFRSLIRKKPSNS
                     KN"
     gene            complement(8180..8779)
                     /locus_tag="JC281_RS11570"
                     /old_locus_tag="JC281_11570"
     CDS             complement(8180..8779)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013752.4"
                     /locus_tag="JC281_RS11570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11570"
                     /product="transposase"
                     /protein_id="WP_015728580.1"
                     /transl_table=11
                     /translation="MRQSKKAIQDFKDRKLKYDKQMEIYGDRKSYSKTDHDATFMRMKD
                     DHMRNGELKPGYNLQIATNNQFVLAFGVYSYPGDTRTLKPFLKSIHKLYGDIPEYIVAD
                     AGYGSEYNYTVILDEFEKTPLITYSMYLKEKQRKYKNNPFITANWEYNVIEDYYICPNK
                     KTLHFQSYRKRRDGYGIQRDFKLYACEACVGCSLRS"
     gene            complement(9237..9875)
                     /locus_tag="JC281_RS11575"
                     /old_locus_tag="JC281_11575"
     CDS             complement(9237..9875)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0030552 - cAMP binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024934.4"
                     /locus_tag="JC281_RS11575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11575"
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="WP_015728579.1"
                     /transl_table=11
                     /translation="MVELLGIKEIIKEKGINNKLCKGEYFQETFEKYIYLVDKGILYVH
                     QDNIDGTTLIYKIIGPDSLFICDNSKYFCGKTEVVFYKMLISSIINDEKTCREYIKLLI
                     NENVKKDMFIRDMLTKDKVCRLLSILVRLANTFGEEEGRMIVIKIKITQEELAQYCGTT
                     RENIARIMKQLKDRKIVDTSSRFIKILSLEEIKQMIPCEGCNSFVCKTF"
     gene            10001..10132
                     /locus_tag="JC281_RS11580"
                     /old_locus_tag="JC281_11580"
     CDS             10001..10132
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: Subtilosin_A"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020361779.1"
                     /locus_tag="JC281_RS11580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11580"
                     /product="subtilosin A family bacteriocin"
                     /protein_id="WP_037544023.1"
                     /sec_met_domain="Subtilosin_A (E-value: 6.6e-22, bitscore:
                     74.7, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKGIMVSNKGCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS"
     CDS_motif       10001..10030
                     /prepeptide="leader"
                     /note="peptide class: sactipeptide"
                     /note="predicted sequence: MEKGIMVSNK"
                     /locus_tag="JC281_RS11580_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       10031..10132
                     /prepeptide="core"
                     /locus_tag="JC281_RS11580_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="31.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="GCSTCSIGAACLIDGPLPDFEVMGITGIFGLTS"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKGIMVSNK"
                     /leader_location="[10000:10030](+)"
     gene            10204..11544
                     /locus_tag="JC281_RS11585"
                     /old_locus_tag="JC281_11585"
     CDS             10204..11544
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014115546.1"
                     /locus_tag="JC281_RS11585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11585"
                     /product="radical SAM protein"
                     /protein_id="WP_338091842.1"
                     /sec_met_domain="subtilosin (E-value: 1.1e-174, bitscore:
                     578.1, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 3.9e-21,
                     bitscore: 72.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 7.9e-41, bitscore:
                     137.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 9.1e-06, bitscore: 22.4,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.2e-21, bitscore: 73.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.8e-05, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6.5e-11, bitscore:
                     39.6, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1e-08, bitscore: 32.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEMNQYIFFNDNARLHQLPHGGVIEVKNGMFKDEVFDFEYLDLNS
                     TAFEACTYFDGSMTIIDILKDMCQKYKCDINDHIEWYTNLVNDLYKKNLINLVSNPVKK
                     NLNISGSTEYITPLHAVFEITHKCNLKCAHCYLESSPQVQDTLSLDEFIMIANNMYENG
                     ILTCEITGGEVFVHPNAKEILEFALKKFKKVGILTNGTLLKPDILDLLIKYKKKIVIGI
                     SLDSVNPEKHDNFRGKKNSFNQTCKTIKKLSENGLFVRVGMSIYEDNMWEINDMANLVR
                     KLGASAFSYNWIDDFGRGKKMNQLKLNKLNNLSFAEFEVDVVKNNRDIIPLVPLTKNKA
                     NNCGAGWRSIVMDPNGNIRPCALFPKEFVIGNLKEQSYKDVFSSEIVNRLYSLQSPQKS
                     KFCSDECSFKDYCAGCYLKGLNSNKNHRTNYCGWVKNQKLENLVEQI"
     aSDomain        10282..10491
                     /aSDomain="Subtilosin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a subtilosin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JC281_RS11585_Subtilosin_rSAM_RRE.1"
                     /evalue="4.60E-23"
                     /identifier="RREFam018.1"
                     /label="JC281_RS11585"
                     /locus_tag="JC281_RS11585"
                     /protein_end="96"
                     /protein_start="26"
                     /score="72.4"
                     /tool="antismash"
                     /translation="KNGMFKDEVFDFEYLDLNSTAFEACTYFDGSMTIIDILKDMCQKY
                     KCDINDHIEWYTNLVNDLYKKNLIN"
     gene            11709..12407
                     /locus_tag="JC281_RS11595"
                     /old_locus_tag="JC281_11595"
     CDS             11709..12407
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="JC281_RS11595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11595"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_015728576.1"
                     /transl_table=11
                     /translation="MMSIHLNNLCIWYEPENLIIKNANLYLQKGKIYGLLGKNGSGKTT
                     LINTICGVIPSFSGDIIINNLNISKFNYQARLERFYVPDSPPVISQMTSKQYISFVLNM
                     YQQTLSQEHLLRISKKYNFERYLDIRMNELSFGNKKKAALICSILLDVPIKIFDEPLNG
                     LDIESIDLFVQDLFKMTKEDKCVILSSHLLDIVKKLTPNIIYINNKHCFQFTLNDESDI
                     RKVLSDYDKE"
     misc_feature    complement(12877..12889)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            12877..13668
                     /locus_tag="JC281_RS11600"
                     /old_locus_tag="JC281_11600"
     CDS             12877..13668
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JC281_RS11600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JC281_11600"
                     /product="hypothetical protein"
                     /protein_id="WP_129821147.1"
                     /transl_table=11
                     /translation="MTISLLLALFLSPFFNKFISLVVLILVLLGVSIFTNFIKFNVKKR
                     KKPTKATVNEISILKWEFKKFFIEKTNVIGIISMFLFLNILNYNIESIDGMTVEFGLKY
                     FLILLIISSISPLNLMFSSDKELRKIATYMPVKKRSIFMAKILVSTLISQFFLSIVVFI
                     NEMLFQEKLGLLYFKVSILLFFLTFLRLKLDMIKPILDYEDKMELWRNPKKYLSLMIVI
                     PPLFVAVALNFYISLVIILSGCLVLELYSQLYGKEDFFGYK"
     gene            13655..14752
                     /locus_tag="JC281_RS11605"
                     /old_locus_tag="JC281_11605"
     CDS             13655..14752
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JC281_RS11605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JC281_11605"
                     /product="insulinase family protein"
                     /protein_id="WP_063284955.1"
                     /transl_table=11
                     /translation="MDINNAINIYNYHVYINKISGVENFTINQLISEILNEKFKALNDY
                     SIIPYTTTSVLGKDFYNIFYLKTLRNRYVDLDYNYWLNSFYNNFQMSDNECYLALEKLI
                     NKIKKYQLNPMNINKLLVKDKLYPNSLLGSKRLGTIETLNMNQISQELVLQRIPESIYA
                     YNLCISKIKGELNIHKLQNIKYASPFFIPHIVSQKVPPLINGQSINTICYYFESNDEYS
                     KTIYGPMLQGYLTQYGHSILFKKLRIEKFQLYHFEAHFDQETNILFIQYIVDENWKIKV
                     WNLIISEVMDLNINKEEFQTMKIFLSNEYRFKFDKSFGELNHILSLGNKFLQSNNIFKA
                     IQDIKIQDFIKFLDNKKMINIVYEG"
     gene            14755..15711
                     /locus_tag="JC281_RS11610"
                     /old_locus_tag="JC281_11610"
     CDS             14755..15711
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012879.4"
                     /locus_tag="JC281_RS11610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11610"
                     /product="insulinase family protein"
                     /protein_id="WP_157929458.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 7e-08, bitscore:
                     29.7, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVTKLFYADLDQNLYNLFQNEIKVTYFNKSDSYINQIKAVVNIG
                     GYQYQTGAAHFIEHLKFWKENNNLYDLMNYFGTIMNANTTEYETNFLLYCSKENTVSTL
                     TNFTSYLLNHSYTIEEFNKEKKIILNEVKGYHSILVDENEKLEYVKKIIGDENQINDIS
                     KRYLENLSSICYQKRNIHYYLIGDFSEYIHKSREISMEKIELVVNSDLIIHDYDNTELF
                     LKTLYFHINKFVNYYFQNKSLVVNFNKLYYTKKIHDIQLDDFRSYIISYIVNVYEDSDL
                     LIEFLENWKFTRGDFTKIGNLLEDQEKLSILLNEAFM"
     gene            15708..16316
                     /locus_tag="JC281_RS11615"
                     /old_locus_tag="JC281_11615"
     CDS             15708..16316
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JC281_RS11615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JC281_11615"
                     /product="hypothetical protein"
                     /protein_id="WP_037544039.1"
                     /transl_table=11
                     /translation="MKKTPIVLLFTFAIVLELSPLKSHLVKLLIKSQLLNPYSWSSFLF
                     ITLLFSIILTPIQGVFYSFNNKMQIVNSVYIKNKFKMTEEVIEISKKIKLPTKKQVFLI
                     LLINVITYDVFISILSGFKLNTPLVAFIPIGIIFMISTYFLVYRFCKQRINHKILIFLM
                     SITFSCVILSYVKEEIVIFIVIEIIVFYLYNMFLKIIKR"
     gene            complement(16778..17293)
                     /locus_tag="JC281_RS11620"
                     /old_locus_tag="JC281_11620"
     CDS             complement(16778..17293)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019166374.1"
                     /locus_tag="JC281_RS11620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11620"
                     /product="hypothetical protein"
                     /protein_id="WP_127505288.1"
                     /transl_table=11
                     /translation="MNQVTKIAVATTLSLGTLLGATAGASAIHTDAHAATEQQTPYYTY
                     NGLFNFKGNKALEDKNFYRALQHDNFKYEGLKVGQSTFADVKKAVGNDVKKYYEEKGVT
                     YYEKNDVIFGIDSEGKLVNMTLLIEKINHSDKSVRDHVKQGEIYDTKTTHVAFYSGNSI
                     VIKAKESR"
     misc_feature    complement(17428..17439)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     misc_feature    17465..17481
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 24.15"
                     /tool="antismash"
     gene            17598..17873
                     /locus_tag="JC281_RS11625"
                     /old_locus_tag="JC281_11625"
     CDS             17598..17873
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015728571.1"
                     /locus_tag="JC281_RS11625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11625"
                     /product="hypothetical protein"
                     /protein_id="WP_015728571.1"
                     /transl_table=11
                     /translation="MAKKSKKSLSVLSTALTGATLVVDFYNSYIYRSKNRKLSYISVGL
                     GLVDVVLSFYLSLGAKSKFTKAWSFFSASRQVWSGIQKIQAIRTRG"
     gene            complement(18254..19261)
                     /locus_tag="JC281_RS11630"
                     /old_locus_tag="JC281_11630"
     CDS             complement(18254..19261)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002498204.1"
                     /locus_tag="JC281_RS11630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11630"
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="WP_014614841.1"
                     /transl_table=11
                     /translation="MRKKFIAAVIGTTAAATALSAHADASTTYRVQPGDSLWAIATKYN
                     ITIAQLKQYNGLNSNLIFPNQVLKVSGGSSTSRTTTHHSSHSTTSSTVYTVRYGDTLSG
                     IAARYGTTYQNIMKWNGLNNFLILPGQKLNVSGPSTTPSRSTAKKPAPKTSSRNASYYT
                     VQPGDSLSLIASKYGTTYQHIMELNGLTSFLIFPGQQLKVSGSAPSRQTTPTPSPSYQS
                     PTFNHQNLYDWGQCTWYVFNKRKEMGRPISTYWWNANAWDDNAARDGYTINNQPAVGSI
                     LQSDLGYYGHVSYVERINADGSILVSEMNFTAAPGILTYRTVPAHRVSAFKYIH"
     gene            complement(19599..19880)
                     /locus_tag="JC281_RS11635"
                     /old_locus_tag="JC281_11635"
     CDS             complement(19599..19880)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019166378.1"
                     /locus_tag="JC281_RS11635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11635"
                     /product="hypothetical protein"
                     /protein_id="WP_201800462.1"
                     /transl_table=11
                     /translation="MNRIRVVYIVNVLNYLFLIVGGLICVQLMLAFGDLLLYFEATSLA
                     AGIFSLWHLNADDAKLQKVGLIWFIINLLNIFVLTPLIILVLFFGISF"
     gene            complement(20401..21543)
                     /locus_tag="JC281_RS11640"
                     /old_locus_tag="JC281_11640"
     CDS             complement(20401..21543)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1168: O-succinylhomoserine sulfhydrylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036666.1"
                     /locus_tag="JC281_RS11640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JC281_11640"
                     /product="bifunctional cystathionine
                     gamma-lyase/homocysteine desulfhydrase"
                     /protein_id="WP_130921205.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3.9e-05,
                     bitscore: 20.2, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 4.2e-07, bitscore:
                     26.4, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.2e-10, bitscore:
                     36.2, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKTLLIHCGNTTDDYTGAVTTPIYQTSTYEQDAIGELRQGFEY
                     SRTANPTRSSLESVIADLEHGNYGFAFGSGMAAISAVIMLLDQGDHIIVGSDVYGGSYR
                     AMTRVFTRFGIEFDFVNTTDVQNIEDKIKDNTKMLFIETPSNPLLRITDIQAVSEIGKQ
                     HELMTVVDNTFMTPYYQTPLSLGADIVVHSATKYLGGHSDVVAGLVAVKDETLAERIAF
                     IQNSTGGVLGPQDSYLLIRGMKTLALRMEQIERNALAVVEMLNQHDKVTKVYHPSQPSH
                     LNYDVHQAQADGTTGIISFEVADVEKAKFLVRQTKYFTLAESLGAVESLISVPSLMTHA
                     SIPADIRAKEGIADGLIRLSLGIEDTDDLVEDLKQALDQL"
ORIGIN
        1 tgaaattgac ccataactca tcgctcctgt tttaaagcgt ttcacaattt cctcaaccgg
       61 ttcgacttgt gcaatatcga tggcctgttg tgatttgaaa gcaaataagt ctcgaatatg
      121 gctgctcgtt tgatcgttcg ccactttaga aaatgcttta aactgcgcat aatcattgtc
      181 gcgacacgca tgttgaagta atcgtatcgt tgttggattg aatgtatgat gttgaccttg
      241 ttgacgccat tggaatgtgc ttcctgggtc taacgtgtca cctttaatcg tttggcgcgc
      301 cttgttttca gcgtctaatg tttcaatgga gatgcccgat aatttagaag ttgtgcccgt
      361 aaaataatcg ttaatcactg cttctgataa ccctaccgct tcaaagattt gcgccccttg
      421 ataactttga accgtagaga tacccatttt cgccattact ttaatcagac cctctgataa
      481 aatggcgttg taacgcgcga cgttatcggc tactacaccg tctaatctac cgtgctctgt
      541 caattgcgca atcgtttgtt gtgcaagata cggaacgact gcattcgcac cgtaaccgac
      601 taaacaagca aggtgatgca cttcacgtgt ttcaccagaa cttgcgacaa tgctcgtttg
      661 catccgtaaa ttttcacgaa ttaataattg atgaatatga ctcaccgcta ataaaatcgg
      721 catcgcatac tggtctactt cggtgacgtc actatcattc aacacgatga tttctgcccc
      781 ttgacgtacc gctttgatga ccacttcccc taagttgtct agcgcttctt ttaatccacc
      841 tatgtaacct gtcgaaaact ctgctaccgt aaagccttct tgtccgatga cgtctaattg
      901 tgctggtgtc aacacgggat gtttcagttg tacccgcttg aggacatccg gccctggttc
      961 cagcaagttg ccttctttac ctaaataact caattcactc gttacaattt tttcacgata
     1021 tgcatcaatc ggtgggttcg ttacttgtgc aaagagttgt ttgaaataat taaacagtga
     1081 ttcaggtcgt tcgctgagta cggcaagtgg tgcgtcgtaa cccattgccc caataggatc
     1141 tttgccacct gtcacgagtt cagttaaata cttgtccaac tcttctttcg tatagccaaa
     1201 gcgttgttgc attttaagaa catggtctac agcgacaggt ccacccgcat atgagaccgc
     1261 ttctaaatcg agcttgtgtt gatacgtttc caaccattcc aaatagggtt gctgctctgc
     1321 aatcgcggtt tttaattcat ggttttcgat aaccttatgt tgattaaaat cgacaagcaa
     1381 tagcttacct ggattcagtt gccctttaaa tacaacatct gcttcgtcta catccacgac
     1441 gccgacttct gatgaaaaga cgatttcatt ttgtttcgta attgtataac ggcctggtct
     1501 caagccattc cgatcggtta aagcccctaa cttgtcacca tcacagaatg aaatcatggt
     1561 cggtccatcc cacggctcca ttaaatagct ataaaattcg taaaatgcgc gtactttcgg
     1621 atcattactt tcgttataca accacggttc tggaatgagt aacatcgctg cttgttcagg
     1681 cgacatcgct aaacttaaaa actctagtgc gttatccaca atagccgagt cactgcccga
     1741 ttcatccaat atttgatgga ctttatgttg cgcctcgccg aaaatcgttt caattaagcg
     1801 acgttgacgg gcacgcatcc agttcacatt accttgaatc gtattaatct caccgttatg
     1861 catgagcaag cgatttggat gtgcacgctc ccaactcgga aatgtattcg tactaaaacg
     1921 cgagtgtacc gaaccaaatt tcgatacgta tgacggctgt tgtaaatcga catataatga
     1981 tttaatttgg tctgaacgca accatccttt ataaacaatg gtacgtgtcg ataaactcgt
     2041 aaaatataaa tctaactgtg cactttcacc atatttttcg atttgcttac gcgcaaggta
     2101 caatgcacgc ttaaagtcct gagcgctctc atttacgacg aagacttgtt gaatgacagg
     2161 catcgtttct gctacatgcg gcgcgagaca cgtcacgtcg accggtactt gacgatcacc
     2221 gatgatacgc aacccttctc cttcaaaaat tgatgccatt accgctgcat gttttgtgtc
     2281 agaaatcatg acgttggcaa acaacatacc taccgcatag tcaccttcag tcggcaaatc
     2341 aaaatcagtg acttctgaga aatattgata aggcacttct gtcataatgc ctgccccatc
     2401 acctgtaata ccatctgcac cgatacctcc acggtgatcg agacggcgta acatttctaa
     2461 agacttttcg acaatctcat gagaacgttc attattcata ttcgcataaa agccaatccc
     2521 acaagcgtca tgttcttcac gactgtcata aagtccgatt ttggaattta aataattgtt
     2581 agacatttct gacacctccc tttagtaata tttcaactat ataggaaagc gatttatcac
     2641 atcaatatat acttgagatg aaatctatct aattttgaga taatataaat tgtaagaggt
     2701 ggaatggtat ggaattgaaa caactcaaat actttgtcga agtcgcaaaa cgtgaacata
     2761 tttctgaagc agcactcgaa ttgaacgtcg cacaatctgc aattagccgt catattcata
     2821 atttagaaaa tgaactcgaa acatcattgt tttatcgtcg cgggcgtaac gtatttttaa
     2881 ccgcagaagg caaacagttg cttgaatatg cgcaacaaat tcttgagcaa gtcgatctca
     2941 ctttgtcgca gtttcaaacg caagtacaac aacagcaaag cgtcttcaca atcggttatg
     3001 tggacggctc aatcggccaa attttaccgc aagtgttaca gacaattgaa aacgagctgt
     3061 ccttgtcact cattcctaca ttgttagatg aacaagagac attacaagcg ttgcgagcac
     3121 aagaaattga ttttgcactg acaactgtca caacgacgga tccaacattt gaaatagtgc
     3181 cattagtaga agaaacgtac gtcttatatg gggacttaca cgcaccaatg atgaacgtgc
     3241 cgaatccacc gttatcacac atattgaaac aaccgttata cttgcttgaa ccgattccta
     3301 cagacttcaa aacatatttg ataacacatg ccgacaaacc cgtccgtgtc ttgaatcaag
     3361 aacaattcgc acgctttatt ttacgcaatc aaaaaggctt cgtacttgca ccaacgtacg
     3421 tcaacttata tagtcaaaat caacaatgga aaaagatttc attgtcacat acagatttca
     3481 aaaaaacgtt acgcctcatt tatcgacgcg atttacaaaa acctttacgt gatgaagtca
     3541 tccaaatcat catgacacat atacaacaac gttcggttta tcattaagga gaatgattta
     3601 tgaagcaact ttcgaaaaaa ataaacacca ttgtcatcgt ggtgagtatc atcgtagcga
     3661 tttgtgcgat agtattcaca cgtttgaata gttcgtttta tcatatcccg ctcggtgaag
     3721 tgacgaaaat tgaaagtcat caccaagaaa agtcagtaga tgaacaacat aatcaagatg
     3781 tgaaatataa agacgtgtta caagtcaaat tgttaaatac aaaacaacaa ggcgacaccc
     3841 ttcacgtcga acaccggtat aacgcctcga aaactgaaga acaagcgtat caaccgggtg
     3901 ataaagtgct actgcacaaa ggaaaaaatc aaaaagatac atatattatt gagaaaaaac
     3961 gcgataccgt actcgtgaca gtcatcagcg cgttctttat tgcattactc attgtcgggc
     4021 aacggatcgg acttcaatcc atcctatcac tcgttattaa cgcgtttgcc atcttgttag
     4081 ccattagttt gtatcacgcg tatccgcaac tgaatctctt tttattaatg agtctcgcag
     4141 tcatgattgc gacgattttg acactttggc tcgtcattgg ttggtcaatg cgtacgattg
     4201 tgaccattgt cagcacttta ctcggcacgt tcatttgtat ttttatcgca tggagtgtca
     4261 tcggtttaac acacgggcaa gggattaaat atgaaacgat gagctttctc acgattcaac
     4321 ctagaaccgt cttccttact tccgtcatgg ttggaacgct tggagcagtg atggatgtcg
     4381 ccattacgat ttcaagcggg atgtatgaag tgctacagcg gtcgccacac atttcaatgc
     4441 aacggtgggt gctcgcaggc cgtaacatcg gtcgtgacat tatgggaacg atgacgaaca
     4501 ttttattatt ctcatatctt gcaggaagtt taccgatgct cttactttat ttaaaaaatg
     4561 gcaacacgct cacttacagc attagcatga attggtcctt agaaatttcc cgggcaatta
     4621 caggcgggat tggcatcgtc ttaactatcc cattgaccat ttttctcatg cgtttatggt
     4681 taagcctacg aggaggtgca acacgatgaa tgccattgtc atcttaggtt tgattctttt
     4741 catactcatg ctcatatttg gcggtaaaac aggactcgtt tcatttttaa cgctattttt
     4801 aaactttatc attttattca ttactgtact cgccatcgtt tttggcgcac cgatttatgt
     4861 tgttactttc attttttgta ttattgtctc gatggttaac ttgtttttac tcaaccgctt
     4921 taatacaaaa actttagctg catttatcgc gagtacggtc acgacattat taatgattgt
     4981 cgccgtttac ttgtccgtac attggggtca tctacaaggt ttcacccaag aagaacaaga
     5041 cgaaacttat atcttctcct taaatattgg gattgatatg gaacagttta tgatttttac
     5101 tgtgctactt gctgtcattg cagcagtgat tgacttggcg attacgatta gctcacctgt
     5161 atttgagtta cacgagacga acccttcatt atccgaacgc gaactgtttc attcaggcat
     5221 gcgcgtcggc cgagaaattt tagcgacgtc tgcgaacacg atttatctcg cattgattgg
     5281 aggttcaatg acaattgttt tttggttttt caacttgcat tacagtttcg gccatatgct
     5341 caatgccaaa ttatttacac aagaagtcat tacaattgct ttaggagggg tcgccattgc
     5401 agtctgtatt ccgattacgg ctatgataac tgcttggctt gtaaaacatc gtcatcaact
     5461 tccttttcat ctagactgag cttcaagccg agtgaaaacg ggtacaatgt gaacgaggtg
     5521 aatttatatg acagcgattc atattcatgg cgcacgtcaa aacaacttaa aaaatattga
     5581 cgtctccatt ccgaaacatc agttaacggt cgtgactggg cgttcaggat ctggcaagtc
     5641 ttccctcgtt tttaatacga ttgccgctga atccgaacga ctattgaacg aaacctattc
     5701 gagttatatt cagcaccaat taacgcaata tgaaaaaccg gatgttgacc atattgaaaa
     5761 cttgcccgtc gcgatggtca tcaatcaaaa aagactcggt ggcaattcgc gctcaacggt
     5821 cggtaccatt tcagacattt atgcgtccgt ccggctattg tggtcgcgta ttggcacacc
     5881 tttcgtcggt tattcagacg tcttttcgtt caataatccg aatggaatgt gtgaacattg
     5941 tcaagggctt ggttatgttg aagatatcga cttgaatgaa ctgctcgatt tcgacaaatc
     6001 tttaaatgaa ggtgcgattc gctttccgtc atttaagccg gatagttggc gcgggaaacg
     6061 ttatcgctat tcgggtttgt ttgataatga taaaaagctc aaagactata caaaagaaga
     6121 gctcgatacg tttctttata ccgagccaac acgcttgaaa aatccaccct cagaatggcc
     6181 taaaactgca aaatttgaag ggttaatcca ccgtttccga cgctcatttt taattaatga
     6241 taactttgaa aagaaacgct ttttaaagga cgttgaacgc gtagtcacca aacaaacatg
     6301 tcctgtctgt cacggacaac gcttaaatca aaaagtgctc agctgcaaaa ttcatggact
     6361 gaacattgcc gattttacag cactgacgat tgaagaaacg ctcccatttt tagagcaaat
     6421 cgacagcgac aaagcgactt atattatcga accattgaaa gcccaactcc aagctttgaa
     6481 tgatattggg ctgaactatt taacgctcgc acgtgaaaca acgacccttt ctggcggaga
     6541 gtcacaacgg attaagctta ttcgtcattt gaacagtccg ttaaccgatc tcgtgtacat
     6601 tatcgacgaa ccgagtgtcg gtttacatcc agcagatatt gaaaaaatca acgaaatcat
     6661 gctcaatatc cgtgacaaag gtaataccgt catcatcgtt gaacacgatc ccgacgtcat
     6721 caaaattgcg gatcacgtga ttgacatcgg acctggcgca gggaaacatg gcggccatat
     6781 tacatttgaa ggcagttatg cacaacttaa acagtccgat accgatacag cgcgcgcatt
     6841 gacacgtcaa catcacttga aacagtcagc gattcgtgac aaccaagcat ggttacactt
     6901 agaacatttg caacacaaca acttacaaga tgtgtctgtt gcgatcccga aaaatgcgca
     6961 aacggttgta acaggtgtcg ctggttcagg aaagagctcc ttaattaaag gcggttttgc
     7021 gaaacatgaa gatgcgatac tcattgatca aaaaggcgta cacacttcca accgatcgaa
     7081 tttattaacg tacacgggta ttttcgatga tattcgtgag tttttcagta aagcaacagg
     7141 attgaaaaaa agtatgttca gttataactc agatggcgcg tgtccaaatt gtaacgggaa
     7201 aggcgtgctc aaaaccgaac tcgccttcat gccagacttc tcgcaagtat gcgaggtgtg
     7261 cggagggacc cgctatcgtc cagaagtgtt ggaaacgaaa gtcgacggtt attctatcgc
     7321 ggacgtgtta gcactcaccg ttgaagaagg cttgtcactt ttccaaacac atgacgccat
     7381 tgctcaaacg ttaagcgcct tgcaatcgac agggctcggc tatatgacac tcggccaatc
     7441 actcgacacc ttatctggcg gggaaattca acgactcaaa ctgacgcgct acatgattga
     7501 gcctgttaca gaaaaaatat ttattttcga tgaaccgaca acaggtttac atgaagatga
     7561 tatcccaatt ttacaggcac gcttcgatca acttattgaa gaaggccata ccgtcatctt
     7621 aattgaacac aatatcacga tgatgacacg agcagactgg ctcattgacg ttggacctgg
     7681 tgcgggaaat caagggggac gcattcttta tagtggacca cctgcaggcc taaaaaacgt
     7741 cgccgaatct cgtaccgctc cccatttatt tggtagttta tcggaataag tggtacattg
     7801 agtatggggc taggacatag accttcagct cctttaagaa aaaaaacgtc aaaattcaat
     7861 ttttagaatt tgatggcttt tttcttatga gcgaacgaaa acgagcactg attttggcca
     7921 gttttcgtat atttactgcc atgagtgcga tgccaagttc acactcaact tttgattggg
     7981 tgcgaaccga taatctttgg aaacccaaat tagctttcag atttacaaaa gttgattcca
     8041 catctatctt tctcttttga taaatgtgct tcgtttttgg atctgaaagc tgcttattta
     8101 tgaaggcttt aaaataatcc caagttagat ttttaaataa acttttattt gtgttagact
     8161 ttgtactttg cttcatacat taacttcgta atgaacagcc cacacacgct tcacatgcat
     8221 ataatttaaa atctctttga ataccgtatc catctcttct ctttctgtaa ctctggaaat
     8281 gtaatgtctt cttattcgga catatgtaat aatcttctat cacgttgtat tcccagtttg
     8341 cagtaataaa tggattgttt ttatatttac gctgcttctc tttgaggtac atactataag
     8401 tgattaaagg tgttttctca aattcatcga gtatcacggt atagttgtat tcacttccgt
     8461 aacctgcatc tgccacgata tactctggaa tgtcaccata taatttgtga attgatttta
     8521 aaaatggttt gagcgttctt gtatcacctg gataactata aacaccaaaa gctaaaacga
     8581 attgattatt ggtagctatc tgtagattgt aacccggttt caactcaccg tttctcatat
     8641 ggtcatcttt cattctcatg aaagtcgcat catgatcagt cttagaataa ctttttctgt
     8701 cgccataaat ttccatttgc ttgtcatatt ttaatttacg gtccttaaaa tcttggatag
     8761 ccttcttact ttgtctcacg ttacttcttt cttttctaag gttttttctt gtctctacat
     8821 cttgagttgt ttcaatttca gacgtgagcg catcattttt atgacctaaa tgcgtctcta
     8881 tttgattcag ttcttcactt gttaattcat gtccagattc acgcttgatt tcaggaataa
     8941 tctcttcaga aacgagttgt tcatataatg ccgttgattt ttcaatgaca gactgactaa
     9001 aacgcttcgt attagccagc cactgaaatg tatacttatt cgcattggct tctatttttg
     9061 tgccatcaat ataaatgaca tcctctgtaa tgagttgttc ttctaataac tgtgctctta
     9121 aaccgaatat tattacactt caattattaa cctcttcctt aaataattta ttattcacat
     9181 ctcacaactt tagcttttaa attcttcctt tcaggctata gtttatcaaa aaagaatcaa
     9241 aaagttttgc aaacgaagct attacatcct tcacatggga tcatttgttt tatctcttct
     9301 aaagataata tttttataaa gcgagaagac gtatctacaa tttttctatc ttttaattgc
     9361 ttcataattc tagcgatatt ctctctcgta gttccacaat attgagctaa ttcttcttga
     9421 gtgattttaa tttttatcac aatcattctc ccttcttctt ctccaaatgt attagctaat
     9481 ctaactagaa tagatagtaa tctacacact ttgtctttag ttaacatatc tctaataaac
     9541 atatcttttt tcacattttc atttatgagt aattttatgt attctctaca agttttctca
     9601 tcatttatta tgctgcttat aagcatttta taaaatacaa cttctgtttt cccacaaaag
     9661 tatttactat tatcacaaat gaacaaacta tctggcccta tgattttata aatcaaagta
     9721 gtaccatcta tgttatcttg atgtacatat aatataccct tatctactag atatatatat
     9781 ttttcaaaag tctcttgaaa atactccccc ttacacaact tattatttat ccctttttct
     9841 ttgataatct ctttaatccc tagcaactct accataacaa tccccccttt ataaaaaatt
     9901 ataccattta aattactttt agtaacatgc gttacaaaac ttttgaataa tttatattaa
     9961 aatgtgtttg tagttaaata aaataaaggg ggataccaaa atggaaaaag gcattatggt
    10021 aagtaacaag ggttgttcga cttgttcaat tggagctgct tgtcttattg atgggccatt
    10081 acctgacttc gaagtcatgg gaattactgg aatttttgga ctaacttctt agcactgttt
    10141 gtatgccggc aaaatgatag gatttatcat agtttgtcgg cgtacttttt attaaggggg
    10201 gggatagaaa tgaatcaata tatatttttt aatgacaatg ctaggttgca tcaattacct
    10261 catggtggag taattgaggt gaaaaatggc atgtttaaag atgaagtgtt cgactttgaa
    10321 tatttagatt taaattctac tgctttcgag gcatgtacgt attttgatgg ttccatgaca
    10381 ataatagata ttttaaaaga tatgtgccaa aaatataaat gtgatattaa cgatcacata
    10441 gaatggtata caaatctagt taacgatttg tataagaaaa atcttattaa tctcgttagt
    10501 aatcctgtta aaaaaaacct taatattagc ggatcaactg aatatattac accactacat
    10561 gcggtgtttg aaattacaca taaatgtaat ttaaaatgcg cacattgtta tctagagtct
    10621 tcacctcaag ttcaagatac gctttcatta gatgaattta taatgattgc aaataatatg
    10681 tatgaaaatg gaattctaac atgtgagatc actggtggag aagtgtttgt acatccaaac
    10741 gcaaaagaaa tattagaatt tgcactcaaa aagttcaaaa aagtcggtat cttaacaaac
    10801 ggaacactgt taaaaccaga tattctcgat ttattaatta aatataagaa aaaaattgtt
    10861 atagggattt cattagatag tgttaaccct gaaaagcacg ataattttcg tggcaaaaaa
    10921 aattcattta atcagacttg taaaaccatt aaaaaacttt ctgaaaatgg gctttttgta
    10981 agggtcggaa tgtctattta tgaggataat atgtgggaaa tcaatgatat ggcgaattta
    11041 gtaagaaaac taggagcttc agccttttct tataactgga tagatgactt tggtagaggt
    11101 aaaaaaatga atcagttgaa attgaataaa ctaaacaact tgtcttttgc tgaatttgaa
    11161 gtggacgttg ttaaaaataa tagggacatt ataccattag ttcctctaac taaaaacaaa
    11221 gccaataatt gtggggctgg ctggcgttca atagtcatgg atcctaatgg aaatattcgg
    11281 ccgtgtgcac tatttccaaa agaatttgta atcggtaact taaaagaaca gtcatataaa
    11341 gacgttttct cctcagaaat agtaaatcga ttatactctc tgcagtctcc acaaaaaagt
    11401 aaattttgca gtgatgaatg cagcttcaaa gactactgcg ctggctgtta cttaaaaggt
    11461 cttaatagta acaaaaacca tcggacgaat tactgcggtt gggttaaaaa ccaaaaatta
    11521 gaaaacttag tagaacaaat ataaaaggag ataaaacatg aaaagagact taattacaat
    11581 aaccattgct ataatttttt taatatctag tgtaatattc gccattaagc aagaatgggt
    11641 tttcgcagta atcttcatat tgatagggat tatctatata ttaaaaacat ttaaaagagg
    11701 taaatctaat gatgagcatt catctaaata acttatgtat ttggtatgag ccagaaaatt
    11761 taataattaa aaatgcaaat ctatacttac aaaaaggaaa aatttatgga ttgcttggaa
    11821 agaatggatc tggtaaaaca acgctaataa atactatatg cggggttata ccaagttttt
    11881 caggagatat aatcattaac aatttgaata tatcaaaatt taattatcaa gctaggttag
    11941 aaagatttta tgtaccagat agtccccctg ttatttctca aatgacaagt aaacaatata
    12001 taagttttgt tttaaatatg tatcaacaaa ctttaagcca ggagcattta ttgagaattt
    12061 ctaaaaaata taattttgaa aggtatttag atataagaat gaatgagctc tcttttggaa
    12121 ataaaaaaaa ggctgcttta atttgttcaa tcttattaga tgtacctatc aaaatattcg
    12181 acgaaccatt aaatggatta gatatagagt caatagattt gtttgttcaa gatcttttca
    12241 aaatgacaaa agaagataaa tgcgtcatcc tatcttctca tttattagat attgtaaaaa
    12301 agctgacacc taatattata tatattaata ataaacattg ttttcaattc acgcttaacg
    12361 atgaaagcga tataagaaag gttctatctg attatgataa agaataatgg atatttaatt
    12421 ctactctatt gctattacta caataaactt aatctaagag ccataattag aaattcacta
    12481 ggaatagcaa ttcttttaat atttgaatac aaattgattg aaagtcattt ggataatgtc
    12541 aatttgttat attccaatta tctaagatta tctatcatat tctcctcaat tatattgact
    12601 aatatttact ggaactcttt ccgcgaaagc gagttatata gactcttagg gtacatgcct
    12661 attaataatg taaaggtttt aataattcta aatgtatata ttttcgttga gataaccggg
    12721 agaagacttg tttttttact tgtactacca ttttatgttt tgctaatcgg caaattcagt
    12781 atttacggga gcattttgac attttcatta ttcatactac tgattgtatc ttctcaactt
    12841 atttgcattc ttttgcatga atgtgaaaag agacatgtga caatttcatt acttctagca
    12901 ctttttttaa gcccattttt taataaattt ataagtttgg tggttttaat tcttgtatta
    12961 ttaggtgtat ccatctttac taattttata aaatttaatg taaaaaagag aaaaaaacct
    13021 acaaaagcta cagtaaacga aatatcgatt ttaaaatggg agtttaaaaa gtttttcata
    13081 gaaaaaacaa atgtcattgg aataataagt atgttccttt tcctcaatat tttaaactac
    13141 aatattgaaa gtatagatgg aatgacggta gagtttggac taaagtattt tttgatatta
    13201 ctaattattt cttcaataag tccattaaat ttaatgtttt catctgataa agaattaaga
    13261 aaaattgcta cttatatgcc tgttaaaaag cgaagtatct ttatggctaa aattttagtt
    13321 tcaacattaa tatcacagtt ttttctttct attgtagtgt tcataaacga aatgctattc
    13381 caagaaaagt taggcttact atacttcaaa gtatctattt tgttgttttt tttaactttt
    13441 ttgagattaa aacttgatat gataaagccc attttagatt atgaagataa aatggaattg
    13501 tggagaaatc cgaaaaaata cttatcattg atgatagtga tccctcccct ttttgtggct
    13561 gtagcactaa atttttatat ttctctagtt attatattat caggttgttt agtattagaa
    13621 ctatatagtc aactttatgg aaaggaagat ttttttggat ataaataacg ctataaatat
    13681 ttataactat cacgtctata tcaataaaat aagtggcgtt gaaaatttca ctattaatca
    13741 attgatttct gaaatattaa atgagaaatt caaagcatta aatgattatt caattattcc
    13801 ttatactaca acaagtgttt tgggaaaaga cttttataat attttttatc taaaaacttt
    13861 aagaaaccgg tatgtagacc tagattataa ctattggctc aatagttttt ataataattt
    13921 tcaaatgtct gacaatgagt gttacttagc cttggaaaaa cttattaata aaattaaaaa
    13981 atatcagtta aatccaatga atatcaataa attattagta aaagacaaac tttacccaaa
    14041 ttcattatta ggaagtaaac gtttagggac tattgaaaca ttaaatatga atcaaataag
    14101 tcaagagtta gtactacaaa gaatacccga atctatatat gcatataatt tatgcatctc
    14161 aaaaattaaa ggagagctaa atatacataa attacagaat attaaatatg catctccttt
    14221 ttttatacca catatagtaa gccaaaaagt tccaccatta ataaatggac aaagtattaa
    14281 cacaatttgt tattattttg aaagtaatga tgaatattca aaaacaattt atggtcctat
    14341 gttacaaggc tacttgacgc aatatggcca ttcaatattg tttaaaaagc taaggataga
    14401 aaaatttcaa ttatatcatt ttgaagctca ttttgatcaa gaaactaata tcctattcat
    14461 ccaatacata gtggatgaaa attggaaaat aaaagtttgg aatttaatta tatctgaagt
    14521 tatggattta aatattaata aagaagagtt ccagactatg aaaatcttcc tatcaaatga
    14581 atacagattt aaattcgata aatcatttgg agaattgaat cacattctta gtttaggaaa
    14641 taaattttta caatcaaata atatatttaa agctatccaa gatataaaaa ttcaagattt
    14701 catcaaattt ctagataata aaaaaatgat aaatattgta tatgagggat gaaaatgaaa
    14761 gttacaaaac tattttatgc agatttagat caaaatcttt acaatctatt tcaaaacgaa
    14821 ataaaagtaa catactttaa taagagtgac tcatatataa atcaaattaa agcagtcgta
    14881 aatatcgggg gatatcaata tcaaaccgga gctgctcatt ttatagagca cctaaaattt
    14941 tggaaagaaa acaataactt atatgattta atgaattact ttggcactat aatgaacgca
    15001 aatactacag aatatgaaac taatttttta ctgtactgta gtaaggaaaa tacggtttct
    15061 actttgacta attttacatc atacttatta aatcacagct acactattga agaatttaat
    15121 aaagagaaga aaataatatt aaatgaggtt aaaggatacc attcaatttt agtggatgaa
    15181 aatgaaaaat tagaatatgt aaaaaagata ataggcgatg aaaatcaaat taatgacatt
    15241 tctaagagat atctagaaaa cctatcttca atatgctatc aaaaaagaaa tattcactat
    15301 tatttaatag gtgatttttc tgaatatatc cataaaagca gagaaataag catggaaaag
    15361 atagagctag tagtaaacag cgatcttatt atacatgatt atgataatac tgaattgttt
    15421 ttgaaaaccc tttatttcca tataaataaa ttcgtaaatt attatttcca gaacaaaagt
    15481 cttgtggtta atttcaataa attatattat accaaaaaaa ttcatgatat tcagttagat
    15541 gattttagaa gttatataat ttcttatata gtaaatgttt atgaagattc tgatttgtta
    15601 attgagtttt tggaaaactg gaaattcaca aggggagatt ttacaaaaat cggtaattta
    15661 cttgaagatc aagaaaagtt atctatatta ttaaatgagg cattcatgtg aaaaaaacac
    15721 ctattgtatt attattcact ttcgcgatag tattagaatt atctcccctt aaaagtcatt
    15781 tagtgaaatt attgataaag tcccaattat taaatccgta ttcttggtct agttttcttt
    15841 ttattacact gcttttttca attattttaa ccccaattca gggtgttttt tatagtttta
    15901 ataataaaat gcaaatagtt aatagtgtat atataaaaaa taagtttaag atgaccgagg
    15961 aagtaataga aattagtaaa aaaataaaat tacctaccaa gaaacaagtg tttttaattc
    16021 tcctaataaa tgtaataacg tatgatgtct ttattagtat cctctcagga tttaaattaa
    16081 acacacctct cgttgcattt attcctatcg gtattatttt tatgatttct acttattttt
    16141 tagtgtatag attttgtaaa caaagaataa atcataaaat cctgattttt ttaatgtcaa
    16201 tcaccttttc ttgcgttatt ctatcatatg tgaaagaaga gattgtgata tttatagtaa
    16261 tagagattat tgttttttat ctttataata tgtttttaaa aattattaaa agataattac
    16321 aaagaactac tctgtatata acttttcagt aaaactaatt acattgactg taggcaacgt
    16381 tacaatgata ctgttaataa ttttacaaat acatttaaac tgaatcttac agacgttata
    16441 gttgtcccta aaatccttac tcatcattta taaatagcga ttttcattaa actttaataa
    16501 gataattctt gtaaaaactc cctttatagg ggggttgttg cacaattgtt ttgattatta
    16561 atatagaaac actgtatttc ttacactctc ctgcaaatac acaacgtctg gctaagtcta
    16621 ttgcagaagc tgaacaaagc cacacgattg cattaaattg aaatacttaa acaagctctc
    16681 atcaactcaa aaactccgag acttatcgtc tactattcac gaaaagtctc ggagtttttt
    16741 taactatgac gttgtatggg caaagtacgc ctcaatctta acggctctct tttgctttaa
    16801 tcacaattga gttgcctgag taaaatgcga catgtgttgt ttttgtatca taaatttcgc
    16861 cttgtttcac atgatcacgc acagatttat cactgtgatt aattttttca attaataatg
    16921 tcatgttgac caatttacct tcgctatcaa taccgaaaat gacatcattt ttctcgtagt
    16981 aagtgacacc tttttcttca taatattttt tcacgtcgtt ccctaccgct tttttaacat
    17041 cagcgaatgt agactggccg acttttaaac cttcatattt aaagttatcg tgttgtaatg
    17101 cgcggtaaaa gtttttgtcc tctaaagctt tattcccttt aaagttaaat aagccgttat
    17161 atgtgtaata aggtgtttgc tgttccgttg cggcatgtgc gtctgtatgg attgcacttg
    17221 ccccagctgt tgcccctaat aatgtgccta atgataaagt tgttgcgact gcaatttttg
    17281 taacttgatt catgtgtacc actcctcttt ctctcgatac tgttctaaaa attaggaatt
    17341 tatgttattt gtaattgtcg aattaaattt ccaatttata ataacttata tatcaaattg
    17401 ttccttactc gaatgataac aaattaagat aacattttca tccaaaagtt tttcggtcat
    17461 tggactgaaa tttttctaca acgctgtatc taaaagacgt gttaacaatc atttaaggaa
    17521 agtgcatatg ttgggttttg acctatcagt aatgttataa tgaatgacat catactatat
    17581 tcattggggg aagtataatg gctaaaaaat ctaaaaaatc attaagtgtg ctttcaactg
    17641 ctttaacagg cgcaacatta gttgtagact tttacaattc ttacatttat cgctcaaaaa
    17701 atcgcaagct aagctatatt tcagttgggc ttggcttagt agatgtcgta ttaagcttct
    17761 atttatcact tggtgcaaaa agcaaattca caaaagcatg gtctttcttc tcagcaagtc
    17821 gccaagtatg gagtggtatc caaaaaatcc aagcgattcg cacacgtggg tagggtaacg
    17881 acttgattca ttttcaaatc attaaatata ggcgtgaaca tgaaacatta tgatttctgt
    17941 tcacgccttt tttatgtagt agtcattgcc cagatgctca agtcgttata tcttcgcttc
    18001 atccaatttt ttaaagctaa tcattaaagc atccgtttct gtgaatatga cgatacaaat
    18061 ggattgactc aacggcttta tccttaccta agaatcatcg acaagatgtt tgttaccatt
    18121 ttgttaatag aatatgacat gcatttcaaa ctttttgggg attttttcaa atgacgaaaa
    18181 ttttctcatt cgacccttgt cttaaaaaat aaaaacgtga gcaccatgta aaaggtatac
    18241 tcacgttttt tgattaatgg atatatttga aggcacttac acgatgcgct ggtacagtac
    18301 ggtaagtgag aatgcctggt gctgcagtga aattcatttc tgatacgagt atactaccat
    18361 cagcattaat tcgctctaca tacgaaacat gaccatagta acctaagtca gattgtaaga
    18421 ttgatcccac tgcgggttgg ttattaattg tataaccatc acgtgcagcg ttatcatccc
    18481 aagcatttgc attccaccag tatgtactga ttgggcgccc catctcttta cgcttattaa
    18541 atacgtacca tgtgcattga ccccaatcgt ataagttttg atggttgaat gtaggagatt
    18601 gataacttgg acttggtgtc ggtgttgttt gacgtgacgg tgccgatcca ctcactttta
    18661 attgttgacc tgggaaaatt aagaaggatg ttaatccatt taactccata atatgttgat
    18721 atgttgtacc atatttagac gcaatcaacg acagtgaatc acctggttgt actgtataat
    18781 aactcgcatt tcttgaagac gttttaggtg ccggcttctt cgctgtggaa cgacttggtg
    18841 ttgtagacgg accacttaca tttaactttt gacctggtaa aatcaagaag ttgttcaaac
    18901 cgttccattt cataatgttt tggtacgttg ttccatatcg cgctgcaatg cctgataaag
    18961 tgtctccgta acgtaccgta tagactgttg atgacgtagt gctatggctt gaatgatgag
    19021 ttgttgtgcg tgatgtactg ctaccaccag aaaccttcaa cacttgattc ggaaagatta
    19081 agttagagtt taatccatta tattgtttaa gttgtgctat tgtgatgtta tactttgttg
    19141 caatagccca aagtgaatca cctggttgta cacgatacgt tgttgaagcg tctgcatgtg
    19201 ctgataatgc tgtggcagct gctgttgttc ctattacggc tgcgataaac tttttacgca
    19261 ttcgtttccc tccttataaa atagaagata ttattcttat acagttttat attatacacc
    19321 gattatcatg tagaaatatg tctgttatat aacattatga ttacaaaaac catcatggcg
    19381 gtcttcagaa agtaaatata tttacacatg cttatttgag aattaaaata atagctatca
    19441 tattattcat aaagacattt ttctcggata tttcttttat ttatctttcg taattgtaaa
    19501 atatttgacc acttcatcat tgtttatgga agtaaactta tgcatcacta taaagcttga
    19561 tacgaccttt ttaacattac aaggtgcgat ttcggtcgtt aaaaacttat gccaaaaaat
    19621 aataccaaga tgattaaagg tgtcaaaaca aatatattaa gtaaattgat gataaaccaa
    19681 attaagccta ctttttgtaa cttcgcatcg tctgcgttta ggtgccacaa tgaaaatatg
    19741 cccgcagcta atgacgttgc ctcaaaatat aataataaat caccaaacgc taacatcaat
    19801 tgcacacaaa tcagtccacc tactattaaa aataagtaat tcaaaacatt cacgatatac
    19861 acgactctga tcctattcat ttatcacgac tcctgttgaa agtccttaat atggtttttc
    19921 atcatactat aaacctagga aacaattctg taacttatca aaattataac attttcatat
    19981 gattgtgatt atatatatta gtttcatact tataaaaaag tgcgtgcatg aagataggac
    20041 ataaaacttt ttggcgctac tgataccgca ttggtttaac ttgtacgctt ccaggacttg
    20101 tcttaactaa atccagtgtc cacgagggcc attttcattt gttgcgtata tcaaaaaagt
    20161 catgccatgt tcaaaacgag acatggcatg acgctgtcga atgtgattga ttttataaac
    20221 gaaattcata aggatttgag gaagacttta actttggtac tagctactgt ttaacgcagt
    20281 agctgtctga cttctcaatg cttgtacttg tgagaagccg agtcagcctt gcgcaggcat
    20341 ttacgacgaa atttttgttg cacaagaggt ttctgtacga ctccctcaac cccatgtcac
    20401 ttacaattga tcaagtgctt gttttaaatc ttctacaaga tcatctgtat cttcaatacc
    20461 caatgataat ctgattaaac catctgcaat gccttctttt gcacgaatat cagctggaat
    20521 cgatgcatgt gtcattaagc ttggtacaga aattaaactt tcgactgcac ctaaactttc
    20581 tgcgagtgtg aaatattttg tttgtcttac taggaatttc gctttttcta catctgctac
    20641 ttcaaatgag atgatgcctg ttgtgccatc tgcttgcgct tgatgcacgt cgtagtttaa
    20701 atgtgacggt tggcttgggt gatacacttt cgtcactttg tcatgttgat tcaacatttc
    20761 gacgaccgct aatgcgttac gttcgatttg ttccatacgt aaagctaatg ttttcatccc
    20821 gcgaataagc aagtagctat cttgaggccc taatacgccc cctgttgagt tttggatgaa
    20881 agcaatgcgc tctgcgagtg tttcgtcttt aactgcgaca agtccggcta caacgtcact
    20941 atgcccacct aaatatttcg tcgctgaatg tacaacaata tctgcgccaa gagacaacgg
    21001 tgtttgataa tatggcgtca taaatgtgtt atccacgaca gtcatgagtt cgtgttgctt
    21061 gccgatttca ctcaccgctt ggatatctgt aatgcgcagc aatggattag atggcgtttc
    21121 gataaataac attttcgtat tatctttaat cttatcttca atattttgaa catctgtcgt
    21181 gttaacaaag tcaaattcaa taccaaaacg tgtgaagaca cgtgtcattg cacgataaga
    21241 gccgccatac acatcagagc caacaataat gtggtcgcct tggtctaata acatgataac
    21301 tgcgctgatg gccgccatgc ctgaaccgaa tgcgaaaccg tagttcccat gctctaaatc
    21361 agcaatgaca gactcgagcg atgaacgtgt ggggttcgct gtacgtgagt attcaaaccc
    21421 ttgtcttaac tccccaatcg catcttgttc atacgtactc gtttgataaa tcggcgtcgt
    21481 cactgcacct gtataatcat ctgtagtatt accgcaatga attaataatg tttttttatt
    21541 catt
//
