LOCUS       NZ_CP065858            22598 bp    DNA     circular CON 16-FEB-2024
DEFINITION  Bacillus halotolerans strain P1 chromosome.
ACCESSION   NZ_CP065858
VERSION     NZ_CP065858.1
KEYWORDS    RefSeq.
SOURCE      Bacillus halotolerans
  ORGANISM  Bacillus halotolerans
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4087194)
  AUTHORS   Cullings,K., Stott,M.B., Bhardwaj,S.R. and Spector,M.
  TITLE     Phylum-level Variation in the Microbiomes of the Basidiomycete Fungi
            Scleroderma citrinum (Pers.) and Pisolithus arhizus (Pers.): a tale
            of two saprotrophs
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4087194)
  AUTHORS   Spector,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-DEC-2020) JQ, NASA-Ames, 5215 Wavecrest Way, Oxnard,
            CA 93035, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2018
            Assembly Method                   :: Velvet v. 1.2
            Assembly Name                     :: NASA.Piso.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/16/2024 03:00:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,218
            CDSs (total)                      :: 4,134
            Genes (coding)                    :: 3,973
            CDSs (with protein)               :: 3,973
            Genes (RNA)                       :: 84
            rRNAs                             :: 7, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 88 of 161
            Pseudo Genes (incomplete)         :: 96 of 161
            Pseudo Genes (internal stop)      :: 27 of 161
            Pseudo Genes (multiple problems)  :: 40 of 161
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:53:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3725506
            Orig. end                         :: 3748104
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP065858.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from 5215 Wavecrest Way, Oxnard
            California 93035.
FEATURES             Location/Qualifiers
     region          1..22598
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="10"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22598
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22598
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12598](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12598)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(12..701)
                     /locus_tag="I7X10_RS18955"
                     /old_locus_tag="I7X10_18955"
     CDS             complement(12..701)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388686.1"
                     /locus_tag="I7X10_RS18955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_18955"
                     /product="hypothetical protein"
                     /protein_id="WP_095714615.1"
                     /transl_table=11
                     /translation="MKRMVFGFLAIAVCGSGFYIYHFLFGDPFSKNAAEQKLTSYVKQT
                     YPQKEIKITNGVYNAKISEYVFQANTQSQSYQMCAMGFLHPKVTCDGIEEAYTESVAKH
                     LNQEASKEIETDLKKAVPQLIKAEADISVENAQFTLETSWSKQLAERAPLSLTIQLDAS
                     GKTKTDAAAIAETVRKTLNQKGYTYFRGTIDCMQKDGDGGFGYVKYSIDFTPEIAIQKN
                     DAEALGS"
     gene            complement(731..1183)
                     /locus_tag="I7X10_RS18960"
                     /old_locus_tag="I7X10_18960"
     CDS             complement(731..1183)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388685.1"
                     /locus_tag="I7X10_RS18960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_18960"
                     /product="DUF6884 domain-containing protein"
                     /protein_id="WP_095714616.1"
                     /transl_table=11
                     /translation="MKRLCIIPCGAKKIWDIQPDAGPTRAEDTYLSPFHQACERYAKAF
                     FDEWVILSAKHGFLRPDDIVPENYDVAFGSGHPEIMTEEKLSRQYREKGFLEKEELVML
                     GGKKYRKVLSTVVGDHQHISWPLAPYKGIGYMLQALNRAVEEKQEL"
     gene            complement(1180..1935)
                     /locus_tag="I7X10_RS18965"
                     /old_locus_tag="I7X10_18965"
     CDS             complement(1180..1935)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="I7X10_RS18965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="I7X10_18965"
                     /product="hypothetical protein"
                     /protein_id="WP_095714617.1"
                     /transl_table=11
                     /translation="MKRMHFCTGIGLLLIVISAYPIFVLLRENIIDHNVTNRYDIHYAY
                     QDKQGYEPAIDTQNINIFNHHIRIIEAKTGKHAPLTSWDKDENVPAGEIVNIQYQLDGR
                     DLSSPSEVWLSNRERGGRYFSWLEILTVKDRKTDQNLVYIVQRITDDQISLEKSKWKII
                     RIHQDGTVKEKLLSYSDRSKDPLSVKLLNFSYVGGNSMGYHSDMYEVIPNVIFPLLYPL
                     ITFAVGCAIMIGILIFVIVQKTKGVRKSI"
     gene            complement(2043..3299)
                     /locus_tag="I7X10_RS18970"
                     /old_locus_tag="I7X10_18970"
     CDS             complement(2043..3299)
                     /GO_function="GO:0004180 - carboxypeptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244: amidohydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003239809.1"
                     /locus_tag="I7X10_RS18970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_18970"
                     /product="amidohydrolase"
                     /protein_id="WP_095714618.1"
                     /transl_table=11
                     /translation="MDMIQIRRDFHRHPELGFTEFRTAGKVVETLQTLGYHVTYGKDAM
                     DGEARRGVPSEKELKRAFDRAIENGADPDIIAPMKGGYTAVIGRLEGNTPGPVVALRFD
                     MDALPITESADADHGPHAKGFRSAFEGNMHACAHDGHTAIGLGVAEALAHRNFAGTLKL
                     IFQPAEEGVRGAYAVTEKGMLDDVDYLLCHHLGTNVPLGEVYGGAEGFLATTKMAVHFR
                     GVSSHAGAAPEHGRNALLGAATALLNIHAIPRFSSGDTRINVGVLEGGTAANIIPQHAK
                     MIIETRSDSEEVNRDLEERVRKIIAHSAAMHELEHEVEIIGGAIPIKCDEEMVSTVLEA
                     AGEVGGFSSLQGIQTGSRGSEDASYMIKRVQERGGKGTYMIIGTDIAAPHHHEKFDIQE
                     DILPRSVQLLKQAALKLLK"
     gene            complement(3323..4858)
                     /locus_tag="I7X10_RS18975"
                     /old_locus_tag="I7X10_18975"
     CDS             complement(3323..4858)
                     /GO_function="GO:0015558 - secondary active
                     p-aminobenzoyl-glutamate transmembrane transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:1902604 - p-aminobenzoyl-glutamate
                     transmembrane transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010333409.1"
                     /locus_tag="I7X10_RS18975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_18975"
                     /product="AbgT family transporter"
                     /protein_id="WP_198097874.1"
                     /transl_table=11
                     /translation="MTKHLPEVMTADSLQKIEHKGILKWIEKAGNKLPDPFMLFIYLSV
                     IIIAMSVLLAGNAVTHPGDGKEVAVKSLLSTEGIHWMLTEAVNNFVQFPPLGLVLTMVL
                     GIGLAERVGLIEAVLQKMMAHVPKAIISYSVVFVGILGNLASDAAWVIIPPVGALIFMA
                     AGRHPLAGFAAAAAGVGSGFTANLMIAGTDALLSGITTQVAQTVDKNAQVSAVDNWFFM
                     AASVFVLAFIGAWVTDKIVEPRLGSYRGEYKPEMAALTGKEIKALKAAGAAALLYAGVI
                     ALLVVPEGALLRDPENGSILSSPFLKGIIPIILLFFITVSVVYGIVAGRIKDQTDVPRL
                     MGDSIKGMSGFIVLVFVISQFIAFFTWSNMGIFMAVKGADFLESVHLTGFPVLIGFSLL
                     TCVVSLFITSGSALWALLAPVFIPMLMLLDFHPAFIQIAYRIADSATNTITPMNPYLPM
                     LMAYYKRYKSDAGFGTVISTMIPYTVLFFLAWLLMMFIWYAFGWPIGPGVYAK"
     gene            complement(4880..6064)
                     /locus_tag="I7X10_RS18980"
                     /old_locus_tag="I7X10_18980"
     CDS             complement(4880..6064)
                     /GO_function="GO:0004180 - carboxypeptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244: amidohydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010333408.1"
                     /locus_tag="I7X10_RS18980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_18980"
                     /product="amidohydrolase"
                     /protein_id="WP_198097875.1"
                     /transl_table=11
                     /translation="MMNEYASIYKNVFEWRRHLHQYPELSFQEEKTAQFVYDTLSSFEN
                     LEISRPTRTSVVARLSGARPGKRIGLRADMDALPIQEEHDSHFRSRHPGVMHACGHDGH
                     TAMLLGAAEILSQKKDELSGEVYFIFQHAEEVHPGGAQEMVKAGVADHLDLCIAIHLFS
                     AMPLGKIGLASGPVTANSDRFDITIKGKGGHASQPEQCIDPLVIASQVITHLQSIASRH
                     TDPAERLVLSVTMCHAGSAYNVIPDTVTLGGTVRTFRKEVRANTEALMETIIKGVTEAH
                     GASYDFDYRHGYKSVVNDPNVTELVRQAAENLWGKDQVFPLAPMMGGEDFSAFSERVPS
                     CYIALGAGTGEMIYPHHHPKFTFDEKALSAGVELFVNSVYFILHSRESISMKIN"
     misc_feature    6292..6303
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 20.32"
                     /tool="antismash"
     gene            complement(6300..7283)
                     /locus_tag="I7X10_RS18985"
                     /old_locus_tag="I7X10_18985"
     CDS             complement(6300..7283)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007408522.1"
                     /locus_tag="I7X10_RS18985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_18985"
                     /product="tRNA-dihydrouridine synthase"
                     /protein_id="WP_198097876.1"
                     /transl_table=11
                     /translation="MTDNFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEFT
                     NSESYCHPDGKDSVRGRLTFTEDEQPMVAHIWGDKPENFRQMSIGMAELGFKGLDINMG
                     CPVPNVAGNGKGSGLICRPEVAAELIQAAKAGGLPVSVKTRLGYTDIDEWRGWLTHVLK
                     QDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGLKLAE
                     QYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDKYSALEARPYKPLPR
                     FFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFESKYLDGAEQQ"
     misc_feature    7408..7424
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.73"
                     /tool="antismash"
     gene            complement(8040..8324)
                     /locus_tag="I7X10_RS18990"
                     /old_locus_tag="I7X10_18990"
     CDS             complement(8040..8324)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097694.1"
                     /locus_tag="I7X10_RS18990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_18990"
                     /product="YfzA family protein"
                     /protein_id="WP_021481197.1"
                     /transl_table=11
                     /translation="MDKVYKKRPLYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMN
                     GFPANIVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN"
     gene            complement(8784..8915)
                     /locus_tag="I7X10_RS19000"
                     /old_locus_tag="I7X10_19000"
     CDS             complement(8784..8915)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014469912.1"
                     /locus_tag="I7X10_RS19000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19000"
                     /product="class III lanthipeptide"
                     /protein_id="WP_188323623.1"
                     /transl_table=11
                     /translation="MKDVLELQQLNEGSDVEASKGKGGLLTLITTIVGTSTISNNCG"
     CDS_motif       complement(8844..8915)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKDVLELQQLNEGSDVEASKGKGG"
                     /locus_tag="I7X10_RS19000_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8784..8843)
                     /prepeptide="core"
                     /locus_tag="I7X10_RS19000_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="0.70"
                     /molecular_weight="1795.1"
                     /monoisotopic_mass="1794.0"
                     /core_sequence="LLTLITTIVGTSTISNNCG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKDVLELQQLNEGSDVEASKGKGG"
                     /leader_location="[8843:8915](-)"
                     /alternative_weights="1813.1"
                     /alternative_weights="1831.1"
                     /alternative_weights="1849.1"
                     /alternative_weights="1867.2"
                     /alternative_weights="1885.2"
                     /alternative_weights="1903.2"
     gene            complement(9057..9188)
                     /locus_tag="I7X10_RS19005"
                     /old_locus_tag="I7X10_19005"
     CDS             complement(9057..9188)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014469912.1"
                     /locus_tag="I7X10_RS19005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19005"
                     /product="class III lanthipeptide"
                     /protein_id="WP_188323621.1"
                     /transl_table=11
                     /translation="MKDVLELQQLNEGSDVEASKGKGGLLTLITTVVGTSTISNNCG"
     CDS_motif       complement(9117..9188)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKDVLELQQLNEGSDVEASKGKGG"
                     /locus_tag="I7X10_RS19005_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9057..9116)
                     /prepeptide="core"
                     /locus_tag="I7X10_RS19005_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="0.70"
                     /molecular_weight="1781.1"
                     /monoisotopic_mass="1780.0"
                     /core_sequence="LLTLITTVVGTSTISNNCG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKDVLELQQLNEGSDVEASKGKGG"
                     /leader_location="[9116:9188](-)"
                     /alternative_weights="1799.1"
                     /alternative_weights="1817.1"
                     /alternative_weights="1835.1"
                     /alternative_weights="1853.1"
                     /alternative_weights="1871.2"
                     /alternative_weights="1889.2"
     gene            complement(9332..9463)
                     /locus_tag="I7X10_RS19010"
                     /old_locus_tag="I7X10_19010"
     CDS             complement(9332..9463)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014469912.1"
                     /locus_tag="I7X10_RS19010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19010"
                     /product="class III lanthipeptide"
                     /protein_id="WP_188323621.1"
                     /transl_table=11
                     /translation="MKDVLELQQLNEGSDVEASKGKGGLLTLITTVVGTSTISNNCG"
     CDS_motif       complement(9392..9463)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKDVLELQQLNEGSDVEASKGKGG"
                     /locus_tag="I7X10_RS19010_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9332..9391)
                     /prepeptide="core"
                     /locus_tag="I7X10_RS19010_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="0.70"
                     /molecular_weight="1781.1"
                     /monoisotopic_mass="1780.0"
                     /core_sequence="LLTLITTVVGTSTISNNCG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKDVLELQQLNEGSDVEASKGKGG"
                     /leader_location="[9391:9463](-)"
                     /alternative_weights="1799.1"
                     /alternative_weights="1817.1"
                     /alternative_weights="1835.1"
                     /alternative_weights="1853.1"
                     /alternative_weights="1871.2"
                     /alternative_weights="1889.2"
     gene            complement(9484..9603)
                     /locus_tag="I7X10_RS19015"
                     /old_locus_tag="I7X10_19015"
     CDS             complement(9484..9603)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="I7X10_RS19015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19015"
                     /product="class III lanthipeptide"
                     /protein_id="WP_187265387.1"
                     /transl_table=11
                     /translation="MNEVLELQQLSKGSEVETAGWTLLTTLIGTSTISNSCNK"
     CDS_motif       complement(9553..9603)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNEVLELQQLSKGSEVE"
                     /locus_tag="I7X10_RS19015_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9484..9552)
                     /prepeptide="core"
                     /locus_tag="I7X10_RS19015_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-1.30"
                     /molecular_weight="2120.4"
                     /monoisotopic_mass="2119.2"
                     /core_sequence="TAGWTLLTTLIGTSTISNSCNK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNEVLELQQLSKGSEVE"
                     /leader_location="[9552:9603](-)"
                     /alternative_weights="2138.4"
                     /alternative_weights="2156.4"
                     /alternative_weights="2174.4"
                     /alternative_weights="2192.5"
                     /alternative_weights="2210.5"
                     /alternative_weights="2228.5"
                     /alternative_weights="2246.5"
                     /alternative_weights="2264.5"
     gene            complement(9631..9759)
                     /locus_tag="I7X10_RS19020"
                     /old_locus_tag="I7X10_19020"
     CDS             complement(9631..9759)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014469909.1"
                     /locus_tag="I7X10_RS19020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19020"
                     /product="class III lanthipeptide"
                     /protein_id="WP_188323620.1"
                     /transl_table=11
                     /translation="MKDVLELQQLSEGSDVEASKGKGGLLTLITTIVGTSTISNNC"
     CDS_motif       complement(9688..9759)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKDVLELQQLSEGSDVEASKGKGG"
                     /locus_tag="I7X10_RS19020_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9631..9687)
                     /prepeptide="core"
                     /locus_tag="I7X10_RS19020_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="0.50"
                     /molecular_weight="1738.0"
                     /monoisotopic_mass="1737.0"
                     /core_sequence="LLTLITTIVGTSTISNNC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKDVLELQQLSEGSDVEASKGKGG"
                     /leader_location="[9687:9759](-)"
                     /alternative_weights="1756.0"
                     /alternative_weights="1774.1"
                     /alternative_weights="1792.1"
                     /alternative_weights="1810.1"
                     /alternative_weights="1828.1"
                     /alternative_weights="1846.1"
     gene            complement(9792..9911)
                     /locus_tag="I7X10_RS19025"
                     /old_locus_tag="I7X10_19025"
     CDS             complement(9792..9911)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="I7X10_RS19025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19025"
                     /product="class III lanthipeptide"
                     /protein_id="WP_188323619.1"
                     /transl_table=11
                     /translation="MKEVLELQQFNEKSEVEPAAWTVTLTTISVTLSTISNHC"
     gene            complement(10001..12598)
                     /gene="lanKC"
                     /locus_tag="I7X10_RS19030"
                     /old_locus_tag="I7X10_19030"
     CDS             complement(10001..12598)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013351405.1"
                     /locus_tag="I7X10_RS19030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19030"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_198097877.1"
                     /sec_met_domain="micKC (E-value: 5.5e-140, bitscore: 465.8,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.3e-16, bitscore: 57.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.7e-17, bitscore:
                     59.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLVYFQHMSEDSKYYIEKSPNAETDPYEVHNMPNYYTVSTEY
                     KSPWKFYNNPNHTLKEQGWKIHISATMNNAQDILKVVSQIIFKHQIPFKHIKDKQSLFN
                     MNSKHGNRTSSGKFIAIYPSSDNMFFGLLNELYEELKHYENGPYILNDKSWKDSNIYYR
                     YGAFKNIYNERGELCIKDENGNLIPDNRQPYYKIPEFVSDFDQYLDTKNNLLDTQDVSN
                     FNDYEFQGVLRFNNGGGIYTGIRKSDGKKVVIKEGRPKVGLDGQLNDAIDRLNIEYEAL
                     NTLTEVEGVVNVLDYFKAWKHVFLVEEFVEGVTLQSWCAINYPFNIENDKNEYISKVKK
                     IINSLIETIKLVHSKDVGMGDLQPQNIMITPESNVKIIDFEAASALSEENGALQTIGYT
                     NKKNKNHKERDWYALKKVLRFCILPIGPVTDIEESIKKKHDMWIENEFGKDVYQYVVNT
                     ENLCDRYLSDTKEKIFKNNYDSEIKKEMDMSKVINGLRNSIESNMLPNSSLIHGDVRQF
                     VMPSGKLNVLTGGTGAALALYRSGNVNKQVRDWIENVLLKKLHVLNDDIGLFTGRAGIA
                     ATLYELGYIEEAMNLFNNLSYEDMKDISLRSGLSGIGLSLISLYLEEDNDDFLVTSEKI
                     ADQIENRIIEDDKLSATDFAAVPIGLIDGWSGISLFYAALYSVTKKEKYYVKSKEYIEW
                     DLKHCKVDEETNTLQTYDDQNPRLLPYLSGGSIGIGVAIWYLNYVGNNNLFREELEQII
                     NLNKVRIAYSGGLFDGVGSFLLIPSMTKENNEISQQIELALKKLELFLIRKDDQVLFPG
                     NFSFRLADDYYSGSAGIILGINSIQFSNPLYWLPIIKIDSFLNKTKKELLLNN"
     gene            complement(12628..14397)
                     /locus_tag="I7X10_RS19035"
                     /old_locus_tag="I7X10_19035"
     CDS             complement(12628..14397)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014469908.1"
                     /locus_tag="I7X10_RS19035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19035"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_232350990.1"
                     /transl_table=11
                     /translation="MTNPNFNSKEFFFLLRKTRPNIRLFILAIFLSGLSAIASTLVPHY
                     LKSLIDYYNILEKINLWDLLGLLAIFLISGVIGAVGSYMLSVVGYNVVANLRNLLWEKI
                     VILPIEFYDKNRSADIASRFVNDTTVIYNLVSNSFSQFINAILIVLFCGVWLFYYDWQL
                     TLVIIVAIPVYLLIFIPLGRILSKLSKMTQSLTGELNVRAVETISSIRLIKSSTAEKLQ
                     VERGKEDIEALRNIGLKQTKWMVILNPIINLMMMLIIISIIGFGGVKLANGSLSPGTFI
                     AFLTLMFYIIGPLNNFGLFFTQIQKTIGATERISQLIYEQGEDQHKGKELAETYKDLVI
                     ENLSFCYGKEDKAFSLNNINLIIKGGSVNALVGPSGSGKTTIISILERYYNPNSGNIYF
                     GEENIELFSLKSWRSQIGYVAQNHDLISGTIRDNLIFGLENPPDEKKIVEACKKAYAWQ
                     FISELPNELETNIGEKGLNLSGGQRQRIAIARMFLKDPNIIFLDEATASLDSHSEQIVN
                     EAMKKLMKDRTAIIIAHRLSTIINADNIIFMENGEVTGQGNHWELKRSHKLYRQFCEQQ
                     FKEDSTDPLVLTN"
     misc_feature    14391..14405
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.9"
                     /tool="antismash"
     gene            14817..16214
                     /locus_tag="I7X10_RS19040"
                     /old_locus_tag="I7X10_19040"
     CDS             14817..16214
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014469907.1"
                     /locus_tag="I7X10_RS19040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19040"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_198097878.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 6.4e-43, bitscore:
                     145.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLRRISMVFIFVIVSSLQPISSHAEESNYDESIIINLDSKVSE
                     STINKVQEKYSNIETNYIKELDLLVIDNIKPSQFSAIKDIAKEKLDAKEIIEDKEISLP
                     DKSKQIPAKVAFSSQFTEDNDTLYDSWLWNIKQVTNDYRSYHINKGSHNTKVGVIDSGI
                     DFNHPDLKNNIVDTGESFVPVEDNTQDFYGHGTSVAGIIAANGGVKGVGPNLGLVPYKV
                     FDKNGKSKTSWVISAIVKATKDDMDVINLSLSTFLSKKDKEDRETIKLFEKAFKFARKH
                     NTLIVAAAGNHGYDISNSKKLAQQLGKPKDNILHLPGGDKDVITVSATTAQNTKASYSN
                     YGKNISIAAPGGDLDPSFLDTNKIDLYSLVWTTSPVNIPQTPLSKSLGFQEGYEPTLGT
                     SVAAPIVTATAALLKTEYYEKYGEEMPIRKVEEILYQNTDHVENLDKNEVGSGIVNAYE
                     SLLNIER"
     misc_feature    14857..14875
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 28.13"
                     /tool="antismash"
     gene            complement(17150..18550)
                     /gene="rlmD"
                     /locus_tag="I7X10_RS19045"
                     /old_locus_tag="I7X10_19045"
     CDS             complement(17150..18550)
                     /EC_number="2.1.1.190"
                     /GO_function="GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="rlmD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388683.1"
                     /locus_tag="I7X10_RS19045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19045"
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="WP_198097879.1"
                     /transl_table=11
                     /translation="MNQQNKKAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPGA
                     LPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQLRE
                     KRDIVIQSLERHTKFKVENMDIRETVGMDNPWNYRNKSQFQIGRSQSGSIIAGLYGLDS
                     HDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFETGEVQ
                     VVLVTAKETLPHKEEIVKAIQNRLPEVKSIIQNVNGAKTSVIFGEKSKPLAGHTVIQEV
                     LGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMWVADGAK
                     EVRGMDVIKESIDDAKKNAKKHGMTNATYVTGTAEHWLPKWTKEGFRPDVVIVDPPRTG
                     CDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQALSKDYRVEYIQPVDMFPQTAHVEAVA
                     QLVLKSSN"
     gene            complement(18664..19527)
                     /locus_tag="I7X10_RS19050"
                     /old_locus_tag="I7X10_19050"
     CDS             complement(18664..19527)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388682.1"
                     /locus_tag="I7X10_RS19050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19050"
                     /product="DNA-3-methyladenine glycosylase"
                     /protein_id="WP_101863609.1"
                     /transl_table=11
                     /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDLKARDIRVPIRNKAG
                     DVCIVKVQALGHADEPEFLVSGETEQEDMMKEIKRIFQWEHDLQHVLDHFSKTNLSAIF
                     EEHAGTPLVLDYSVYNCIMKCIVHQQLNLSFAYTLTERFVHTFGEQKDGVWCYPKPETI
                     AALDYQDLRELQFSMRKAEYAIDTSRMIAEGSLDLSELPQLTDEDIMKKLIKIRGIGPW
                     TVQNVLMFGLGRPNLFPLADIGLQNAIKRHFNLDDKPAKDVMLAMSKEWEPYLSYASLY
                     LWRSIE"
     misc_feature    complement(19597..19611)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.07"
                     /tool="antismash"
     gene            19646..20605
                     /gene="corA"
                     /locus_tag="I7X10_RS19055"
                     /old_locus_tag="I7X10_19055"
     CDS             19646..20605
                     /GO_function="GO:0015087 - cobalt ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0015095 - magnesium ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006824 - cobalt ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0015693 - magnesium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="corA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388681.1"
                     /locus_tag="I7X10_RS19055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19055"
                     /product="magnesium/cobalt transporter CorA"
                     /protein_id="WP_198097880.1"
                     /transl_table=11
                     /translation="MINITAITTQHQLLKNIPIERVEQPDIAWYWVDFYGPEETETALL
                     RDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVLHALNQETLETEEVDIFHGEKFVVTF
                     HLHETPGIAKVRERLYASPDMLKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIEDSR
                     SHKTYGTLMSEVFELRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDIYDHL
                     LKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYGMNFDN
                     MPELHWKYGYFAVLGLMAALVAGMLIWFVHKGWFNIFK"
     misc_feature    complement(20676..20691)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.93"
                     /tool="antismash"
     gene            20705..21568
                     /locus_tag="I7X10_RS19060"
                     /old_locus_tag="I7X10_19060"
     CDS             20705..21568
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010333403.1"
                     /locus_tag="I7X10_RS19060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19060"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_198097881.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 4.1e-08, bitscore:
                     30.7, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIAVIGLGNMGQPIARNVLQAGYRLTVYNRTKEKTEEFASQGAQ
                     VAETPRQAAETADIVVTMLSDDNSVSNVTFGKDGLIEGLSENGIHISMSTISVEFSEKL
                     AAAHAEKGQSFLAAPVLGRPDAAAKAALRIIAAGPAEAKKTAKPLLESLSQQVFDVGEE
                     SKTANAAKISINFLLVSMLEALSESFLLMEKYGLEQKQFLEIANALFGSPVYQNYGTIM
                     AEQTFEPAGFKMSLGLKDTNLALAAAEQVSANLPLAELAKGHFESGIEKGLGNLDWAAL
                     IKCIEK"
     gene            complement(21603..22394)
                     /gene="pdaA"
                     /locus_tag="I7X10_RS19065"
                     /old_locus_tag="I7X10_19065"
     CDS             complement(21603..22394)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pdaA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388679.1"
                     /locus_tag="I7X10_RS19065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="I7X10_19065"
                     /product="delta-lactam-biosynthetic de-N-acetylase"
                     /protein_id="WP_024120592.1"
                     /transl_table=11
                     /translation="MKWMCAICCAAVLLAAGAKQADAVPNEPINWGFKRSVNHQPPDAG
                     KQLNSLIKKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHHVTGTFFVTGHFV
                     KDQPELIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNLYLR
                     PPRGVFSEYVLKETKRMGYQTVFWSVAFVDWKINHQKGKKYAYGHMIKQAHPGAIYLLH
                     TVSKDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMKLPSL"
ORIGIN
        1 cggaaatctt atcaacttcc taatgcctct gcatcgtttt tctgaatggc gatttcagga
       61 gtaaaatcaa ttgaatattt tacataacca aagccgccgt ccccatcctt ctgcatgcag
      121 tctatcgtgc ctctgaaata tgtataccct ttttgattaa gcgtttttct gacggtttcc
      181 gctatcgccg cggcatctgt ttttgttttt ccgcttgcat ctaactgtat cgtcaaactt
      241 agcggcgctc tttcagccaa ttgcttgctc cagcttgtct ctaatgtgaa ctgggcgttt
      301 tcaacgctga tatctgcttc ggcttttata agttgcggaa cggctttttt caaatctgtt
      361 tcgatttcct ttgatgcttc ttgatttaga tgttttgcaa cagactcggt ataggcttct
      421 tcaattccat cgcaggttac cttaggatgg agaaacccca tcgcgcacat ttggtagctt
      481 tgagattggg tgtttgcttg aaacacatat tccgagattt tcgcgttata aactccattc
      541 gtgatcttga tttctttttg aggataggtc tgtttcacat atgatgtgag cttttgctct
      601 gcggcatttt tggaaaatgg atcaccgaat aaaaaatgat agatataaaa gccgcttcca
      661 cataccgcaa tggcaaggaa gccaaacacc attcttttca ttttcacacc cttttcgggt
      721 tatgtacgta ttacagttct tgtttttctt caaccgccct gttcagtgcc tgaagcatgt
      781 aaccaatgcc tttgtacggt gccagcggcc agctgatatg ctgatgatct ccgacgaccg
      841 tgctcaggac tttacgatat tttttcccgc cgagcatgac gagctcttct ttttcaagaa
      901 aacccttttc acgatattga cggcttaact tctcctctgt cataatctct ggatgaccgc
      961 tcccgaatgc cacatcgtag ttttccggca cgatgtcatc aggacgcagg aacccgtgct
     1021 tcgccgacaa aatgacccac tcgtcaaaaa aagcttttgc ataccgctcg cacgcctgat
     1081 gaaacgggct caggtaagtg tcttccgccc tcgtcggccc cgcatcaggc tgaatatccc
     1141 agattttttt cgcgccgcag gggatgatgc atagtcgttt catattgatt ttcgaactcc
     1201 ttttgtcttc tggactatca caaagattaa aatcccgatc atgatcgcac aaccaacagc
     1261 gaacgtaatc aacggataca aaagaggaaa tatgacattg ggaatcactt catacatatc
     1321 agaatgatac cccattgaat ttcctccaac gtatgaaaaa ttgagcagtt ttacactcaa
     1381 tggatccttg cttctatcag aatagcttag aagcttctcc tttacagtcc catcctgatg
     1441 aatcctgatt attttccatt tgcttttttc aagacttatt tgatcgtcag ttattctctg
     1501 aacaatgtaa accagatttt gatcagtctt tcgatccttt accgttaata tttcaagcca
     1561 tgaaaagtat cttcctcctc tttctcgatt agaaagccat acttcagaag gtgatgagag
     1621 atctcggccg tctaattgat actgtatgtt aacaatctct ccggcaggga cgttttcgtc
     1681 tttatcccag cttgtcaggg gcgcatgttt tcctgttttg gcctcaataa tcctaatatg
     1741 atgattaaat atgttgatat tttgagtatc tatcgcaggt tcataacctt gcttgtcttg
     1801 atatgcataa tgaatgtcat aacgatttgt tacgttgtga tctattatat tttctctcaa
     1861 tagtacaaag ataggatagg ctgaaatcac gatcagcagc aggcctatac ctgtacaaaa
     1921 atgcattctc ttcatttgat tctcctcttt ttttcatacc tattaatgta ccataaatcc
     1981 aacaaatcgt ctcctttatt tggaaagcgt ttcgaatgac ataaaaaaga ggggatcccc
     2041 ctctacttca acagcttcaa tgccgcttgc ttcagcagct gtacgcttcg cggaagaata
     2101 tcttcctgga tatcgaactt ttcatgatga tgcggggcag cgatgtcggt gccaatgatc
     2161 atatatgtcc cttttcctcc ccgctcctga actcttttga tcatatagct tgcgtcttca
     2221 cttcctcttg agccggtctg gatgccttgc agtgaggaaa atccgccaac ctctccagca
     2281 gcttctagca cggtcgaaac catttcctcg tcacatttga tcggaatcgc tccgccgatg
     2341 atttcgacct catgttcaag ctcatgcatg gctgcgctgt gggcgatgat ctttctcacc
     2401 cgctcttcca gatcgcggtt gacctcttct gaatctgacc gcgtttcaat gatcattttc
     2461 gcgtgctgcg ggatgatatt ggccgctgtt ccgccttcaa gcacgccgac attgatccgg
     2521 gtatcgcccg agctgaaacg cggaatggca tgtatattta aaagcgccgt cgccgcccct
     2581 agcaaagcat ttctgccatg ctcaggagcc gctcctgcat gtgaggagac gccccggaaa
     2641 tgaacagcca ttttcgtagt ggccaggaat ccttctgcac cgccgtatac ttccccaagc
     2701 ggcacattgg tccccagatg atggcagagg agataatcaa catcgtccag catgcctttc
     2761 tcagtaacgg catacgctcc gcggacaccc tcctcagcgg gctggaaaat cagcttcaga
     2821 gtacctgcaa agtttcgatg tgccagcgct tcagcaacgc ctagcccgat cgcggtatgt
     2881 ccgtcatggg cgcatgcgtg catatttcct tcaaatgcag aacggaagcc cttggcgtga
     2941 ggaccatggt cagcatctgc gctttctgta atcggaagtg catccatatc aaaacgaagc
     3001 gcaacgacgg gtcccggcgt attcccttca agtcttccga tgacagcggt atacccgcct
     3061 ttcatcggcg caatgatatc aggatcggct ccattttcaa ttgcacggtc aaaagcgcgc
     3121 ttcagttctt tttctgaagg aacgcctctg cgggcctcgc catccattgc gtccttgcca
     3181 tatgtcacgt gatatcccag ggtttgaagg gtttccacaa cctttccggc tgtgcgaaat
     3241 tctgtgaagc ccagttcggg atgccggtga aaatctcgtc ttatttgaat catatccata
     3301 tgtctcccac cctttgccgt ttttattttg cataaacgcc cggtccgatc ggccagccga
     3361 aagcgtacca aatgaacatc atgagaagcc acgccaagaa gaacagaacc gtatacggaa
     3421 tcatggttga tatcacagtt ccgaagcccg catctgattt gtagcgctta tagtaagcca
     3481 tcagcatcgg caaatacgga ttcatcggcg taatggtgtt tgttgcggaa tccgcaatcc
     3541 gataggcaat ttgaataaac gcgggatgaa aatccagcag catcagcatc gggataaaca
     3601 cgggggccag cagcgcccat aaagcagagc cgctcgtaat aaacagactg acgacacaag
     3661 tcagcaacga aaatccgatt aatacaggaa acccggttaa atggacggat tccagaaagt
     3721 ccgctccttt tacagccata aaaattccca tattgctcca cgtgaaaaaa gcgataaact
     3781 gtgaaatgac aaagacgagc acaataaagc ctgacatgcc tttaatggaa tctcccatca
     3841 gcctcgggac gtctgtctga tccttaatgc gtccggccac gatgccatag acaaccgata
     3901 cagtaataaa gaacagcaga atgatgggga tgatgccttt cagaaaaggc gaggaaagaa
     3961 ttgatccgtt ttcaggatca cgcaggagcg ctccctctgg aacgactaat aacgcaatga
     4021 ctccagcata taaaagagcc gctgccccgg ccgccttcag tgctttgatc tcttttcccg
     4081 ttaacgccgc catttcaggc ttgtattctc cgcggtagct gccaagccgg ggttcaacga
     4141 ttttatcagt aacccatgca ccgataaaag ctaaaacaaa tacggaggcc gccatgaaaa
     4201 accagttatc gacagccgat acctgagcat ttttatcgac ggtttgtgcg acctgtgtgg
     4261 taatgccgga aagaagcgcg tctgtcccgg cgatcatcag attggccgta aatcctgacc
     4321 ctacacctgc cgcagcggcc gcaaagccgg caagcggatg acgcccggct gccatgaaga
     4381 tcagggcgcc aaccggcggg ataatgaccc atgccgcatc agacgccaga ttccctaaaa
     4441 tcccgacaaa tacgacggaa tagctgatga tcgctttcgg aacatgcgcc atcatctttt
     4501 gcagcacagc ctcgatcaaa ccgacgcgtt ccgccagccc gatgccgagc accatcgtga
     4561 gcacaagtcc gagaggcgga aattgaacaa agttgttcac cgcttccgtc agcatccagt
     4621 gaatgccctc ggtgctgagc aaactcttaa cggctacctc tttcccgtct cccggatgtg
     4681 tcactgcgtt tcctgccagc aaaacagaca tggcaatgat gatcaccgat aagtagataa
     4741 ataacataaa aggatcaggc aatttgtttc cggccttttc gatccacttt aatattcctt
     4801 tatgctcgat tttttgtaaa gaatcagcgg tcatgacttc cggcagatgt ttagtcatag
     4861 cgccctccta taatcggttt tagttgatct tcattgaaat cgattcacgg gaatgcagaa
     4921 taaaatagac tgaatttaca aataattcaa cacctgctga taacgctttt tcatcgaacg
     4981 tgaatttagg atggtgatgc ggatagatca tctccccggt tcccgctccc aaagcgatat
     5041 aacagctagg cactcgttca gaaaacgcgg agaaatcctc tccgcccatc attggcgcta
     5101 acggaaatac ctgatccttc ccccacagat tctctgctgc ttgtctgacc agttcggtta
     5161 cgttcggatc gtttaccaca gacttgtatc catggcggta atcaaaatca tacgacgcgc
     5221 catgggcttc agttacgcct tttataatgg tttccatgag cgcttccgta tttgcccgaa
     5281 cttcctttcg aaacgtcctt accgtccctc caagcgtcac agtatcgggg atcacattgt
     5341 aggcggagcc cgcatgacac atggtaacag agagcaccag tctttcggca ggatctgtat
     5401 gtcttgaggc aatgctttgc aaatgagtaa tgacttgtga ggcaatcaca agcgggtcaa
     5461 tacactgttc aggctgagag gcatgcccgc cttttccttt aatcgtgata tcaaagcggt
     5521 cagagttagc ggtgaccggg cctgatgcca gtccgatttt tcctaaaggc atggcagaaa
     5581 acagatggat ggctatgcat agatcaagat ggtccgcaac accagccttc accatttcct
     5641 gcgctccgcc aggatgaacc tcctctgcat gctgaaaaat aaagtagact tcgccgctaa
     5701 gctcatcctt tttctgagac aaaatctcag ccgccccaag cagcatggcg gtatgcccat
     5761 catgcccgca cgcatgcatc acacctggat ggcgggagcg aaaatgactg tcatgctcct
     5821 cttgaatcgg cagcgcatcc atatcagcgc gcagcccaat tcgtttgccc ggccgagcac
     5881 cgctcagccg ggcaacgaca cttgtccttg tcgggcggct gatctcaaga ttttcaaaag
     5941 aagagagcgt atcatataca aattgagctg ttttttcttc ttgaaaggac agctccgggt
     6001 attgatgaag atgtctcctc cattcaaaca cgttcttata tatactggcg tattcattca
     6061 tcatgcttcc agcccccatt ctgttttaga aactcttgca tttactttat tgattatatg
     6121 gggctggttc aattggaatg tcagacaatc tgacttattg aatcaaaaaa gaagaggaaa
     6181 tctgacagat tcctcttcgt ctgttgtatt tttgcacagt gaaaataaac ttttcctaaa
     6241 taactaactt ataaagcaaa aagagcgtcc cgcttcgctt ttaccgaatt agaaaacgtt
     6301 tactgttgct ccgccccatc aagatactta ctctcaaagt catcgagcaa tgcacgcact
     6361 tcatctgttg acttagtgtt catgcactgg tttcttaatt cacttgctcc gcggaatccg
     6421 cggaggtaaa ttttgaaaaa gcgaggaaga ggcttgtatg gacgcgcttc taatgctgaa
     6481 tatttatcat gaagatccag atgcagccgt aagagatcaa gcaattcctt actgctatgc
     6541 tctttcggct ccttttcaaa ggcaaatgga tttgtaaaaa taccgcgccc tatcataatt
     6601 ccatcgacac cgtattgttc agcaagtttt aatccagttt ggcggtcagg aatatctcca
     6661 ttgatcgtca acagtgtatc tggcgctacc tcatcacgaa gtttcttaat ctccgggatg
     6721 agttcccaat gcgcatccac tttgctcatt tccgctcttg tgcgcaaatg aatggaaaga
     6781 ttagcaatgt cctgtttcaa tacgtgtgtc agccagccgc gccattcatc tatatccgtg
     6841 taaccaagtc tagttttcac gcttactggc aatccgcctg cttttgctgc ttgtattagt
     6901 tctgctgcaa cctctggacg acaaataagg ccgcttccct ttccatttcc cgcaacatta
     6961 ggtacaggac agcccatatt gatatctaga cccttaaacc ctagttccgc cataccaata
     7021 ctcatttggc gaaagttctc aggcttgtct ccccatatat gagctaccat tggctgttca
     7081 tcctccgtga aggtcaaacg gccgcgcaca ctatccttcc catcggggtg acaatagctc
     7141 tccgagtttg taaactctgt aaaaaacaca tccggcctgc ctgcttcact tactacatga
     7201 cggaaaacaa catctgtcac atcttccatt ggtgccagta caaaaaatgg ccgtggtaat
     7261 tcacgccaga aattatctgt cataacaaaa atcaaatcct ttcattaggg gatacggcta
     7321 tacctttatc tcaatatcaa aaaactgacc atgctttttt tacactatcg catgcgaaag
     7381 catttcttat caatctatag taaattttga acatttcacg tgggatgatt atctacacct
     7441 attttttata ttgtggctaa cactggcgcc gaccttcgtc tttcttagtg gccttacttt
     7501 tgaacttttt ggataaatag tattccaacc taaatagaat atcatatgag ttctccatat
     7561 taccaacgca aaataattgt cctgttattg aagataagat atttaacgct acaccatatc
     7621 cgtatctcaa tatcatattt gcggaaaaac taatttcaag agatatactt tgattaagca
     7681 aattgagttg ggggtggtat aactgagtac tcaagagaat gaaaaaacct ctacttaagc
     7741 ttgctaccac ttatgaatca catggagtaa agaggatgag aagagaaaat aaactcctac
     7801 ttaaaaaaat gcaagaactt taatctgaac catttgggat ttgctcatga tttagaaaat
     7861 aataaccaac gcagcaagtg gcaacctact atatatttgt atagggttat aattcggtaa
     7921 tcctgatcca gaaccaataa aatagactgc tgactaagtg tcgcagtctt cactcataag
     7981 ataattaaga aagtgttcat tttctttcat cattaaataa ggcatcagaa gttattgctt
     8041 taatttcgaa tatcctttgt tatccctgta attatttgta taatagtgaa aactcccaag
     8101 aaaacagtaa taatattaaa ccatggatta tcatagaatg aaagatatgt ttgaaagaaa
     8161 tctagttcaa ctatgtttgc tgggaatcca ttcatttctc tatacttagg accccatccc
     8221 gttaattcta caaaattaaa ataaagctga gatactaaaa atgccaaaaa tgtttgaaac
     8281 caacttcttt tatataacgg tcgtttttta tatactttat ccatttagtt atccatttcc
     8341 ttctctgcaa tactttttag ccaagtgtca atctaaaatc attatattat gaagcatgat
     8401 tgtcgcaata attacttatt aaggatataa ccattgtagg tattactgta atagttgtta
     8461 tggttggtcc cacttgcggt tccacctcgg cactattatt taattgttgt aatgctaaaa
     8521 cattattcat taatattcct ccattcttca ttttataaat ttagcatttt tgattttagt
     8581 tctacatata aatgaagaac taagtccctt cattcatttt ccattgacaa taaaaaagaa
     8641 gtatgggata gtaaaaagaa tttatacgaa agctaaattt gttccttttt ttggaaacag
     8701 gaaaaggatt ggggtccttt tcctgttcag gctttcatat aatgtataac gaccaagcat
     8761 acttttttag tgtgtttggt cttttatcca cagttgttgc taatagtaga tgtgcctact
     8821 atcgttgtga ttagtgtaag caagccacct ttgccttttg aagcttctac gtcagatcct
     8881 tcattgagtt gttgaagttc caatacatct ttcatttggt ttgacctcct ttttatcatt
     8941 tattacaact ttgctaatag taaatgtacg atgagtgtta ttagaagtga gcacccattg
     9001 ttcctacttc agcacttgat gtacgtaaga aaatcttttt tgttatgtgt ggccttttat
     9061 ccacagttat tgctaatagt agacgtgcca actaccgttg tgattagtgt aagcaagcca
     9121 cctttgcctt ttgaagcttc tacgtcagat ccttcattga gttgttgaag ttccaataca
     9181 tctttcattt ggtttcatct cctttttatc atttattaca actttgctaa tagtaaatgt
     9241 acgatgagtg ttattagaag tgagcaccca ttgttcctct acttcagcac ttgatgtacg
     9301 taagaaaatc ttttttgtta tgtgtggcct tttatccaca gttattgcta atagtagacg
     9361 tgccaactac cgttgtgatt agtgtaagca agccaccttt gccttttgaa gcttctacgt
     9421 cagatccttc attgagttgt tgaagttcca atacatcttt catttggttt catctccttt
     9481 ttatcattta ttacaactat tgctaatagt agatgtaccg atgagtgttg tcagaagtgt
     9541 ccacccagct gtttctactt cagaaccttt actcaattgt tgtaactcta gtacttcatt
     9601 catttgttca tccacccctc ttaattaccc ttaacagtta ttgctaatag tagatgtgcc
     9661 aactatcgtt gtgattagcg taagcaagcc acctttgcct tttgaagctt ctacgtcaga
     9721 tccttcactg agttgttgaa gttccaatac atctttcatt tggtttcacc tcctttcaag
     9781 tactctttct tttagcaatg attgctaatg gtagataatg taacagaaat agttgttaga
     9841 gtaacagtcc atgccgcagg ctctacttca gatttttcat tgaattgttg aagttctaac
     9901 acctctttca ttttcttttc tcacctcctt cgtaagttct gtatattaac tgctttaatt
     9961 ccaatcttca atgattatca tcaactataa gtgttagagt ttaattgttt aacaacaatt
    10021 cttttttagt cttatttaag aaactatcaa tttttattat tggcaaccaa tataacggat
    10081 ttgagaactg gatagagttt atgcccaata ttatgccagc acttccggag tagtaatcat
    10141 ctgctaaacg aaaactgaag tttccaggga ataatacttg atcatctttg cggataagaa
    10201 acaattctag ttttttcaat gccagctcaa tctgctgact gatttcatta ttttccttag
    10261 tcattgacgg gattaacaag aaactaccga ccccatcaaa caatccaccg ctatatgcaa
    10321 ttcttacttt atttaaattg attatttgct ctaattcttc tctaaataaa ttattatttc
    10381 ctacataatt taaataccaa atagcaaccc ctattccgat tgatcctcct gataaatagg
    10441 gtagtaatcg agggttttga tcatcatacg tttgcaaagt attcgtctct tcatctacct
    10501 tacaatgttt taaatcccac tcaatgtatt cttttgactt tacataatat ttttctttct
    10561 tagtaactga atataatgcc gcatagaata aagatattcc tgaccaacca tcaatcaaac
    10621 ctatagggac tgctgcaaaa tcagttgctg ataatttatc atcttcaata atcctatttt
    10681 ctatctgatc agcaattttt tcagaagtaa ccaaaaagtc atcattatct tcctccaagt
    10741 ataagctaat taatgaaaga cctattcccg acaatcctga ccttaatgaa atatctttca
    10801 tatcttcata tgacagatta ttgaataagt tcatagcttc ctctatgtac cccaattcat
    10861 acaatgttgc tgcgatacca gctcgtcctg taaataaccc aatatcatca ttaagtacat
    10921 gcaatttttt cagtaaaaca ttttcaatcc aatcccgaac ttgcttgttg acgtttccag
    10981 atctgtacaa tgccaatgca gctccagttc ctccagttag tacatttaac tttccagatg
    11041 gcattacaaa ttgccgcaca tcgccatgaa ttagcgagct gttgggcaac atattactct
    11101 ctatgctgtt tctcaatcca tttataactt ttgacatgtc catttctttt ttgatttcac
    11161 tgtcataatt attcttgaat atcttttctt tggtgtcaga taagtatctg tcacatagat
    11221 tttctgtatt tacaacatat tgataaacat ctttaccaaa ttcattctct atccacatat
    11281 catgtttctt tttaatgctt tcttctatat cagtaactgg acctattggc agaatacaaa
    11341 atcttaaaac tttctttagt gcataccaat ctcgctcctt atgattctta tttttcttat
    11401 ttgtatatcc aattgtttgc aacgctccat tttcttcaga aagagcacta gcagcctcaa
    11461 aatcaataat cttaacattt gattcggggg taatcattat attttggggt tgcaaatctc
    11521 ccataccaac atctttacta tgtactagtt taattgtttc tatcaagcta ttaattattt
    11581 ttttcacctt actaatgtat tcatttttat cattctcaat gttgaaagga taattgattg
    11641 cacaccatga ttgaagggtt acaccttcta caaattcttc aactaaaaat acatgtttcc
    11701 atgctttaaa gtaatcgagc acattaacaa caccttcaac ttctgtaagt gtatttaatg
    11761 cttcgtattc tatattcaat ctatcaatcg catcatttaa ttgaccatct aatcctactt
    11821 taggtctccc ttctttgatc accactttct ttccatctga ttttcttatt cctgtatata
    11881 taccgccacc attgttaaac ctaaggactc cttggaactc ataatcatta aaattactta
    11941 catcttgagt atctaataag ttattcttgg tatctaaata ttgatcaaaa tcacttacga
    12001 attcaggtat tttataatat ggctgcctat tgtctgggat taaatttcca ttttcgtctt
    12061 taatgcaaag ttctcctctt tcattgtaaa tattcttaaa tgcaccgtat cggtaatata
    12121 tattgctatc cttccatgat ttgtcattta gtatatatgg tccattctcg tagtgtttta
    12181 attcttcata aagttcattt aataacccga agaacatgtt atcagaagaa ggatagatag
    12241 cgataaattt tccagatgaa gttcgattac catgctttga attcatatta aaaagagatt
    12301 gtttatcttt aatatgctta aatggtatct gatgtttaaa tataatttga ctcacaactt
    12361 ttaatatatc ctgagcatta ttcattgtcg cacttatgtg tattttccag ccttgttctt
    12421 tgagggtatg attgggatta ttataaaact tccacggtga tttatattct gtactaacag
    12481 tatagtaatt tggcatatta tgtacttcgt atggatcagt ctctgcattt gggcttttct
    12541 ctatatagta ctttgaatct tcactcatgt gttggaaata aactaatttt ttgtccattt
    12601 tgttctcgcc tctcttaagc gctcttttta attggttaat actaatggat cggtactatc
    12661 ttctttaaac tgctgctcac agaattgacg atacaattta tgactacgct ttaactccca
    12721 atgattccct tgacctgtca cctcaccatt ttccataaaa atgatattgt cagcgtttat
    12781 aatggtggat aacctatgtg ctattataat agcggttcta tccttcatga gcttcttcat
    12841 tgcttcgttc acaatttgtt cagaatgact gtcaagactt gcagttgctt catccaaaaa
    12901 gattatattt ggatccttca gaaacattct cgcaatagca attctttgtc gttgtcctcc
    12961 tgataagttt agaccttttt ctccaatatt agtttctaac tcgttaggca attcacttat
    13021 aaattgccat gcatatgcct tcttacatgc ttctactatt tttttttcat ctgggggatt
    13081 ttctaaacca aagatgagat tgtctctaat agtaccgctt attaaatcgt gattctgtgc
    13141 tacatatcct atttggctac gccatgattt taatgaaaat aactcaatat tctcttcacc
    13201 aaaataaata tttccgctat taggattata atatctttcc agaatagaga tgattgtggt
    13261 tttaccacta ccactaggac ctactaaggc atttacactt ccccctttta ttattaaatt
    13321 aatattattc aaggaaaatg ccttatcctc tttaccatag caaaatgata aattttcaat
    13381 cactaaatct ttataggttt ccgctaattc tttcccttta tgctgatctt ctccttgctc
    13441 atatatcaat tgagaaattc tttctgttgc acctatcgtc ttttgtattt gagtaaagaa
    13501 taacccaaag ttattaagtg gacctatgat atagaacata agtgtcagaa atgcaataaa
    13561 ggttcctggc gataaacttc cattggctaa tttaacccct ccgaatccaa ttatgctaat
    13621 aatgataagc atcatcatta aattaatgat agggtttaaa ataaccatcc attttgtttg
    13681 ctttaggcct atatttctta aagcttcaat atcttctttt cctctttcta cttgtaattt
    13741 ttctgcagtt gaagatttaa ttagtcttat tgaggatatt gtttcaacag ctcttacatt
    13801 taattctcct gttaagcttt gtgtcatttt agataatttt gataaaattc ttcctaaagg
    13861 tataaaaatc aacaaataaa ctggaattgc tacgataatc accaatgtca attgccaatc
    13921 atagtaaaac aaccaaactc cacaaaaaag cactattaat atagcattaa taaattgcga
    13981 aaaagagtta cttactaagt tgtaaatcac cgtagtatca ttaacaaatc tacttgctat
    14041 atctgcagaa cgattcttat cgtaaaattc tataggtagt attactatct tttcccataa
    14101 taaatttctg agatttgcaa caacgttata tcctactaca cttaacatat aactaccaac
    14161 tgccccgatt actccgctga ttaaaaatat tgccagaaga cctaaaagat cccataaatt
    14221 gatcttttca agaatattat aatagtctat tagacttttt aaataatgag gcactaaagt
    14281 agaagctatt gcgcttaatc cacttaaaaa tattgccaat ataaataatc ttatattcgg
    14341 tctggttttt ctcagtaaga agaaaaactc tttcgagtta aaattggggt tggtcatcat
    14401 tttcacctct tccatttatt ccaatgtttc gactttttaa atcgaatgac tcatgatacc
    14461 tttcctaata ttcctataaa caatatttca cacataataa ctgcaagtca atatataatt
    14521 ttacaaatta tgaaaaaaca ggtctttggt tttgcattat tctactcatg tatatttacc
    14581 catagtaatt ttgacccgca aaaccacagg tgtagtaaaa gaataaaaag aagtttaatt
    14641 taatcatact aaaggtgaat ttctcgggat aattactgat aattagaaaa atatgtattg
    14701 actgatttac ttatatttta taaacttgaa tttaatatac ttatttttgg aaagggggta
    14761 aattatatac aatcttatta tttaatgaaa tgtattaagg gaaaggagta taaaaaatga
    14821 agaatttaag aagaatttcg atggttttca tatttgtaat tgtatccagt ttacagccta
    14881 taagctctca tgctgaagaa tcaaattatg atgaatctat cataattaac ctcgactcaa
    14941 aagtaagtga atcgacaata aacaaggttc aggaaaagta ttcaaatata gaaacaaatt
    15001 atattaaaga actagattta ttggtaatag ataatataaa accaagccaa ttttcagcaa
    15061 tcaaagatat tgctaaagaa aaattagacg caaaagaaat tattgaggat aaagagattt
    15121 ctcttcctga taaaagtaaa cagattcctg ctaaagtggc attttcatca caattcacgg
    15181 aagataatga cactctttat gacagttggt tatggaatat caagcaagtt acaaatgatt
    15241 atcgaagtta tcatataaat aaaggatctc ataatacaaa agtaggagta atcgattcag
    15301 gcatagattt caatcatcca gacctcaaaa ataatattgt agatactgga gagtcttttg
    15361 ttccagttga agataataca caagactttt atgggcatgg aacttctgtg gctgggataa
    15421 ttgctgctaa tgggggtgta aaaggagttg gaccaaatct tggtttagtg ccgtataaag
    15481 tatttgataa aaacggtaaa tctaaaacaa gttgggttat aagcgcaatt gttaaagcta
    15541 cgaaagatga tatggacgta attaatttaa gtttatctac tttcttatca aaaaaagata
    15601 aagaagatag agagactata aaactttttg aaaaagcttt taaattcgct agaaaacaca
    15661 atactttaat tgttgcagca gctggaaacc atggatatga tatctcaaat tcaaaaaaac
    15721 ttgcacaaca attaggtaaa ccaaaggaca atatcctaca tcttcctggt ggtgataagg
    15781 atgtaattac tgtatctgcc accacagcgc aaaatacaaa agcttcttac tcaaattatg
    15841 gaaaaaacat ctcaattgca gctccaggtg gtgatcttga cccaagtttt ctggatacaa
    15901 ataagattga tctatatagc ttggtatgga ctacttcccc tgttaatatc ccgcaaactc
    15961 cgctaagtaa gtcactaggc tttcaagagg gatatgaacc tactttaggg acaagtgtag
    16021 cagctccaat agtaactgct acagcagccc tattaaagac agaatactac gaaaaatacg
    16081 gagaggagat gccaattcgt aaggttgaag aaatcttata tcagaacaca gaccacgttg
    16141 aaaacttaga taagaatgaa gttggtagcg gtatcgtaaa tgcttacgaa tcattgctta
    16201 atattgagag atagaagata ttaagcagtt atcgaacttt cactaaaaat actttgataa
    16261 ataaaaaaag attactagac gataatgatg atgaagctag agatgaaata aaccgtattt
    16321 atgagatatt tcacaagcaa cttactatta ctaagttgct tgtgtcatat tttattacag
    16381 cctgagtatt caattcttta gctacaagct tgttgatttc tttatccgca ctaaacccag
    16441 catgtaacag cacctaagcc ggtattcaaa gattagccaa ccaaataata aaaatgggaa
    16501 ataaaaaact tataacccac tccccttcag aacctatcat tagaaagtaa gtcgtctttg
    16561 tataccttgg ttaacgttta agtagttcat ttttcctata acatttgaat taatgactgt
    16621 agaaagctag aatttactaa gaaatagctg ttatttgacc aaagaatata ctctcttagt
    16681 tgtgttctag attctttatt attttttaaa aaatacgtta agtaatgcag ctttcatcaa
    16741 ttccactcaa aaggacagac atgaactctc ttctcttaca tctccaattg taaatttatg
    16801 ttttaaatat tacagaagaa acaaatctct tccctcttac tatgtacaaa aataatatac
    16861 atttcctaaa tcagaccctt ccaacccgca ttccaccgtt cgagttaaaa taaacttttc
    16921 ctaccgaatc cccattttca tactttttct attcaaaatg ggttgttttt cacccgcttt
    16981 tcaacacgct ttttcaactc ttttcgtcag ttaaaataaa gatctcctag aaatgaagga
    17041 agataaaatt cagaaaagac agtcaaggcg aggtttgcgc atgaaaaaga cccagaaatc
    17101 ggcaatgttc attctaccga aatccagatc tgattaggaa ttgattattt tagttagacg
    17161 atttcaatac aagctgcgcc actgcttcaa cgtgagccgt ctgcggaaac atatcgacag
    17221 gctgaatata ttccacgcga tagtctttcg acagcgcctg taaatccttc gcaagtgtgg
    17281 atggattgca ggaaacgtag acaaagcgtt tcggtttgac ttttttgatc gtatccagga
    17341 acgtgctgtc acagccggtt cttggcggat caacgatgac gacgtccggg cggaagcctt
    17401 ctttcgtcca tttcgggagc cagtgctcgg ctgttcctgt tacgtacgtg gcgtttgtca
    17461 tgccgtgttt tttggcattt ttcttggcat cgtcaatcga ttctttgatg acgtccatgc
    17521 cgcggacttc cttcgctccg tcggccaccc acatgccgat ggtgccgacg ccgcaatacg
    17581 cgtcaacgac tttttctttc ccggtcagct gcgccgcttt tttcacttca tcatacagct
    17641 tgacggtttg ctccggattg agctggaaga aggcgcgggc gctcaattca aaagatacgt
    17701 cgccaagcac ctcttgaatc acggtatgtc cggcgagagg ttttgatttc tcaccgaaaa
    17761 taacagaggt tttcgctccg tttacatttt gaataatgga tttcacctca ggcaggcgat
    17821 tttggatcgc tttgacgatt tcttccttgt gcggaagcgt ttcttttgct gttacaagca
    17881 cgacctgcac ttcgcctgtt tcaaagccga ctctcgtcac tatcgtgcga acgtcgcctt
    17941 ttcgttttct ttcattataa acagacacat tgaagtcctc taaaatgcgg cggacgatgc
    18001 ctgttgtttt gttggttgcc ggatgctgaa cgatgcagtc tttgatcggt acgatatcat
    18061 gagaatcaag gccgtataag ccggcaatga tgctgccgct ttgtgagcgt ccgatctgga
    18121 attggctttt gttgcggtaa ttccatgggt tgtccatgcc gaccgtttct ctaatatcca
    18181 tgttttcgac tttgaacttc gtatggcgct ccagagactg gatgacgatg tcgcgctttt
    18241 cccgaagctg ctggctgtat gcaagatgct gaagctggca gccgccgcac tgctcgtaga
    18301 cagggcaagg cggtgccacc cgatgctccg aagccttgcg aatcttcttg atccgtccct
    18361 ccgaaaactt cggctgcact ttcgtcgctt ggacgacaac ctcttcacca ggaagcgcgc
    18421 cgggcacgaa cacgactttt ttcttgaaat agccgacgcc ttccccatta attccgagac
    18481 gtttaatcgt cagcggaaag gtctgtccga ctttcagttc gacgggcgcc tttttgtttt
    18541 gttggttcac gttgttctct ccgtttctat atgaagcttt ctgcagatag cagaaagtga
    18601 aatgtttttt tcacatcttt ctagtataac acgtttgcac gatttccttc actgtcagac
    18661 gaattattct atactcctcc acaaatataa cgacgcatag ctcaaataag gctcccactc
    18721 cttgctcatc gcgagcataa catcctttgc cggtttgtcg tccaaattga agtggcgttt
    18781 gatcgcgttt tgcagtccga tatcggccag cgggaataaa ttgggccgtc cgagcccaaa
    18841 catcagcacg ttttgtaccg tccatgggcc gatgcctctg attttgatca gtttcttcat
    18901 gatgtcttca tccgtcagtt ggggcagctc tgacaagtcg agcgaacctt cggcgatcat
    18961 tcgcgacgta tcaatggcgt attccgcttt tctcatgctg aattggagct cgcggagatc
    19021 ttgataatcc agcgccgcaa tcgtttccgg cttcggatag caccacacgc cgtccttctg
    19081 ctcgccgaac gtatggacaa accgttctgt caaggtgtac gcaaaagata gattcagctg
    19141 ctggtgcaca atgcatttca tgatacagtt gtacacgctg tagtctaata ccagcggcgt
    19201 gcctgcatgc tcttcaaaaa tcgcggaaag attcgttttt gagaaatgat caaggacatg
    19261 ctgcaaatca tgttcccatt gaaaaatccg tttgatttcc ttcatcatgt cttcctgctc
    19321 tgtttccccg ctgacgagaa actcgggctc gtccgcatgg cctaacgcct gcaccttcac
    19381 aatacatacg tcaccggcct tatttctgat cggcactctt atgtcccgcg ctttcaaatc
    19441 aactgcatta agaggatcta acgacagcct gtcgagcaca cggtcaaaat ggtacggcgg
    19501 tgtgaccgat actttttctt tccacatatg atcagccctt tttccgtttt ttgttcagta
    19561 taccacgccg ctggaaatcg gtagaaaaca ctgtatactt ttctgaaaaa ggctgcatga
    19621 tataatggca ggtggagggt tgtttatgat caacattacc gctatcacaa cacagcatca
    19681 gcttttgaaa aatataccga tcgaacgggt tgaacagccg gatattgcgt ggtactgggt
    19741 tgatttttac ggcccggagg aaacggaaac cgcgttattg agagattttt ttcattttca
    19801 tccgcttgcg attgaagatt gctttcagca tatgcagcgt ccgaagcttg accattacga
    19861 cggctatcgc ttttacgtgc ttcatgcgct gaatcaggaa acacttgaaa ccgaggaagt
    19921 cgatatcttt cacggcgaaa aatttgtcgt cacctttcat ttacacgaaa cgcccggtat
    19981 cgccaaagtc cgggagcgtt tatatgcttc accggacatg ttaaaaaaag ggccggggca
    20041 tatttcttac atgatcatgg atcagcttgt tgatgaatat tttcctctgg tgtacaaaat
    20101 agaagaccgg ctgaatgaga ttgaagacag ccgcagccac aaaacatacg ggacgctgat
    20161 gagcgaggtg tttgagctca gaactgacct attgcatctc aggcggacca ttattccgat
    20221 gcgtgatttg ctgtatcgga ttttaagcct tgaccatgtg aaggagcagc gggaaacaaa
    20281 ggcatacttc agcgatattt acgatcattt attaaagctt tcagaaattg tggaatctaa
    20341 ccgcgacatg acgtccgatt tgcgtgacag ctacgtgaca ctgaattcga acaggatgaa
    20401 tgcgattatg atgacattga ccatcgtgtc tacgattttt atcccgctca cgtttatcgc
    20461 cggcgtttac ggcatgaact tcgacaacat gccggagctt cactggaaat acggatattt
    20521 cgccgtgctt ggcctgatgg ccgctcttgt ggccggcatg ctgatatggt ttgtacataa
    20581 aggatggttc aacatcttta aatgaggaca gcgtgaagct gttcttttta ttttggtaag
    20641 ccgctttcca gcatatcctg ttcattttgt atataatgaa aaaaatgttc agggagtgat
    20701 catattgaaa atcgctgtga tcggactcgg caatatggga cagcccattg cccggaacgt
    20761 gcttcaagca ggctatcgtt tgacagtata caatcggacg aaagaaaaga cggaagaatt
    20821 cgcatcccag ggcgcccaag tggcagaaac gccgcgccag gcggccgaga ccgctgatat
    20881 tgtcgtgaca atgctttccg atgacaattc tgtcagcaac gtgacgttcg gcaaagacgg
    20941 attgattgaa gggttatcag agaatggcat tcacatttcg atgagcacga tcagtgtgga
    21001 gttctcagaa aaacttgcgg ccgcccatgc agaaaaagga caatccttcc ttgcggctcc
    21061 tgtgctggga agaccggatg ccgccgcaaa agccgcgctt cgcattatag cggcaggacc
    21121 cgcggaagca aaaaaaacag caaaacctct gctcgaaagc ttgagtcagc aagtgtttga
    21181 cgtcggcgaa gaaagcaaaa cagcaaacgc agcgaaaatc agcatcaatt tcctgctcgt
    21241 atccatgctg gaggcgttat ctgaatcatt cctgttgatg gagaaatacg gattagagca
    21301 aaaacaattt ttagagatcg ccaacgcgct tttcggctcc cccgtatatc aaaattacgg
    21361 aacgatcatg gctgagcaaa catttgagcc ggcgggcttt aaaatgtcat tagggttgaa
    21421 ggacaccaat ctggcgctcg ccgccgcgga gcaggtttct gcaaacctcc ctcttgccga
    21481 gctggcgaaa ggccattttg aaagcggtat tgaaaaaggg cttggaaacc tagattgggc
    21541 cgctttaata aaatgcatag aaaaatagta aaagcctctc tattgcggag aggctttcat
    21601 gtttacaaag acggcagctt catttctttc tcaaacatca agtcatcaat gcttttaaag
    21661 gtatagcctt gttttttcag gtcggtaatc gcatcgtcca gcgcctcggc attgtccttg
    21721 gagacagtgt gaagcaggta aatcgcaccc ggatgcgcct gtttgatcat gtggccgtag
    21781 gcgtattttt tccctttttg atgattgatt ttccagtcga caaaagcgac ggaccagaaa
    21841 acggtttgat agcccatgcg ttttgtttct ttcagcacat attcactgaa cacgccgcgc
    21901 ggcggccgta agtataggtt gtcctgcttt cccgtgatct tataaacttc ctcgttgact
    21961 gaatcaagct cgtcctgaat ttggtctgct gtttttgtcg tcagatccgg atggtgaaag
    22021 gagtggttgc cgatgatatg cccttcatcc gacatccgtt tgatcagctc gggctgatcc
    22081 ttcacgaaat gcccggtgac aaaaaacgtt cctgtcacgt gatgtttttt taagacatca
    22141 agcacttttg gcgtatagcc attttcgtag ccgttatcaa atgttaaata aattgttttt
    22201 tcttttgtat tgcctaaata aaacgcgtca tattttttga tcaggctgtt cagctgtttt
    22261 cccgcatctg gcggctgatg attaacgctt cgcttaaagc cccaattaat cggctcattc
    22321 ggtaccgcat ctgcctgttt tgctcctgct gcaagcagga cggcggcgca gcatattgca
    22381 cacatccact tcatggccag cgctccttct gcattttttc ttattttaca gaaaggcgcc
    22441 ctgttttata ctgacgcttt atgccaatat aaaaaaccgc ggcatgcgcg gttttattcc
    22501 cagtcttttt taaatcgttc atatttggct tccaggtcat ccagcatgcc gatgagcctg
    22561 tctatatctt caacgtctgt tgcttcaggg tctaatga
//
