LOCUS       NZ_CP048882            21155 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces bathyalis strain ASO4wet chromosome, complete genome.
ACCESSION   NZ_CP048882
VERSION     NZ_CP048882.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces bathyalis
  ORGANISM  Streptomyces bathyalis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Rohde,M., Schumann,P., Hahnke,R.L.,
            Sproer,C., Bunk,B., Kampfer,P., Schupp,P.J. and Wink,J.
  TITLE     Streptomyces bathyalis sp. nov., an actinobacterium isolated from
            the sponge in a deep sea
  JOURNAL   Antonie Van Leeuwenhoek 114 (4), 425-435 (2021)
   PUBMED   33595745
REFERENCE   2  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Schupp,P. and Wink,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2020) Microbial Strain Collection, Helmholtz
            Centre for Infection Research, Inhoffenstrasse 7, Braunschweig,
            Niedersachsen 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-FEB-2019
            Assembly Method                   :: HGAP v. v3
            Assembly Name :: Streptomyces_DSM106605_HGAP3_1SC_10M
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 117.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015910445.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 04:35:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,467
            CDSs (total)                      :: 6,387
            Genes (coding)                    :: 6,276
            CDSs (with protein)               :: 6,276
            Genes (RNA)                       :: 80
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 111
            CDSs (without protein)            :: 111
            Pseudo Genes (ambiguous residues) :: 0 of 111
            Pseudo Genes (frameshifted)       :: 37 of 111
            Pseudo Genes (incomplete)         :: 90 of 111
            Pseudo Genes (internal stop)      :: 12 of 111
            Pseudo Genes (multiple problems)  :: 25 of 111
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7166715
            Orig. end                         :: 7187870
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048882.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from MISG, Helmholtz Centre for
            Infection Research, Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21155
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="25"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21155
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21155
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11155](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11155
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    535..552
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.88"
                     /tool="antismash"
     misc_feature    complement(656..670)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.84"
                     /tool="antismash"
     gene            1099..1899
                     /locus_tag="G4Z16_RS31195"
                     /old_locus_tag="G4Z16_31160"
     CDS             1099..1899
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016162.4"
                     /locus_tag="G4Z16_RS31195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31160"
                     /product="DUF427 domain-containing protein"
                     /protein_id="WP_197353903.1"
                     /transl_table=11
                     /translation="MTLTLGGGPLASRSPQTVNYTIDGPAHRLLWQHFPRRVRALLGSS
                     TLLDSTDAKLLHESNLLPQLYVPFADLREEVLEESSHSTHCPFKGDARYWSVRVGDRFV
                     ENAVWSYPEPLDGAEWLKGHAAVYWSAMDAWFDEDEEVSGHVRDPYHRIDVRPTSRHVV
                     VRAGGTDVAESRRAFLLSETGLPNRFYLPQQDVRAELLSPSATHTHCPYKGQASYRTLR
                     TADGVIEDAAWCYEQPLDEATRIAGYLCFLADGVETVVDGTPLS"
     gene            2044..2631
                     /locus_tag="G4Z16_RS31200"
                     /old_locus_tag="G4Z16_31165"
     CDS             2044..2631
                     /EC_number="1.-.-.-"
                     /EC_number="1.4.3.5"
                     /GO_function="GO:0004733 - pyridoxamine phosphate oxidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017945496.1"
                     /locus_tag="G4Z16_RS31200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31165"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_197353904.1"
                     /transl_table=11
                     /translation="MGKIYERIDERLRAFIEEQHIFFTATAPLAADGHVNVSPKGLAGS
                     FAVLDDVTVGYLDLGGSGAETIAHLRENGRVTLMWCAFDGPPRIVRIHGTGVPVFRDDP
                     RWQELLPHFDVSMQSRTDLRAVITVRAERISDTCGFAVPFMDHKGDRQLHTQRFARETD
                     ESFSRYCEKKEHVGVSLDGLPALPLPLPRRIR"
     gene            2728..4170
                     /gene="gndA"
                     /locus_tag="G4Z16_RS31205"
                     /old_locus_tag="G4Z16_31170"
     CDS             2728..4170
                     /EC_number="1.1.1.44"
                     /GO_function="GO:0004616 - phosphogluconate dehydrogenase
                     (decarboxylating) activity [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="gndA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018848256.1"
                     /locus_tag="G4Z16_RS31205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31170"
                     /product="NADP-dependent phosphogluconate dehydrogenase"
                     /protein_id="WP_197353905.1"
                     /transl_table=11
                     /translation="MSSSAHIGVTGLAVMGRNLARNFARNGYTVALHNRTVSRTRDLVR
                     DFSDEGSFIAAETAEEFVAALERPRRLVIMVKAGAPTDAVIDEFAALLEPGDVIIDGGN
                     AHYADTRRREKAMRERGLHFVGTGISGGEEGALHGPSIMPGGSAEAYDSLRPMLESIAA
                     KAPDGTPCTTHVGPDGAGHFVKMVHNGIEYADMQLIGEAYHLLRDVAGYSPDRIAETFR
                     EWNTGRLDSYLIEITAEVLSHSDGATGQPFVDVVADEAEQKGTGRWTVQTALDLGVPVS
                     GIAEAVFARSLSGHADLRSASSHLAGPAAAALSPDDAERFAGQVEQALYASKITSYAQG
                     WNMISSGSQEYGWEIDPGAVAAIWRAGCIIRAVFLDRIRAAFAGRPDLPTLLADEHFSK
                     EIGDAQGDWRTVVATAVQHGIPVPGFSAALASYDSLRSARLPASLTQGQRDFFGAHTYR
                     RTDRDGSFHTLWGGDRSELSAD"
     gene            complement(4735..4965)
                     /locus_tag="G4Z16_RS31210"
                     /old_locus_tag="G4Z16_31175"
     CDS             complement(4735..4965)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004019.1"
                     /locus_tag="G4Z16_RS31210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31175"
                     /product="DUF6480 family protein"
                     /protein_id="WP_197353906.1"
                     /transl_table=11
                     /translation="MDEKYPDPEDPRHTPGLEPGGQVPPGETPPGEDSTAGAGPDERHN
                     PAKGWAKTPVIILALLVAVFFIYFLAWAIEL"
     gene            complement(5037..5696)
                     /locus_tag="G4Z16_RS31215"
                     /old_locus_tag="G4Z16_31180"
     CDS             complement(5037..5696)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719759.1"
                     /locus_tag="G4Z16_RS31215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31180"
                     /product="alpha-ketoglutarate-dependent dioxygenase AlkB"
                     /protein_id="WP_197353907.1"
                     /transl_table=11
                     /translation="MDALIPAPPSRPAPGAVHLPGWLGLQEQRDLVSACRAWAAGPVPL
                     RHTKLPRGGVMSVQTVCLGWHWQPYRYTRTADDVNGLRVAGFPEWLARLGQRALADAYG
                     DDAAAREYEPDTALINFYDGSARMGMHQDKDERSAAPVVSLSIGDTCVFRFGNTESRSR
                     PYTDLHLSSGDLFVFGGPSRFAYHGVTKVFPGTGDPATGMASGRLNLTLRVTGLTD"
     gene            5920..6186
                     /locus_tag="G4Z16_RS31220"
                     /old_locus_tag="G4Z16_31185"
     CDS             5920..6186
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569422.1"
                     /locus_tag="G4Z16_RS31220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31185"
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="WP_197353908.1"
                     /transl_table=11
                     /translation="MEISGIISAIVIGTIIGVLGRLIVPGRQRVGIFLTIGVGIVAALI
                     GSAIATYFGVGDTNGVDWIEWLIQLVLAALGVSALDRSKRRRR"
     gene            6374..7426
                     /locus_tag="G4Z16_RS31225"
                     /old_locus_tag="G4Z16_31190"
     CDS             6374..7426
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008081 - phosphoric diester hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542938.1"
                     /locus_tag="G4Z16_RS31225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31190"
                     /product="phosphatidylinositol-specific phospholipase C
                     domain-containing protein"
                     /protein_id="WP_197353909.1"
                     /transl_table=11
                     /translation="MSRSRLAVAISTAALVTAATALAIPVTAQAGPEKAAAPTYGDTTS
                     VGVHNAYEQDKYEYFADALDSGASLLELDVWTNVIGKGWRVSHSNPTGNDNNCENAASA
                     DELRTKERDQSLDGCLADMRAWHDAHPGHPPVLIKVEMKDGFYDKADRGPDELDSLLSE
                     KLGDALFRPSDVTGSHANLDEAVGSTGWPDRDAMAGKFLFELIPGTVEEDNPADDLWTD
                     EEYATHLKDLSAKGALGEAGAFPAVHGAEKGDPRTERYDEALRPWFVVFDGDAATFAGG
                     GIDTAWYQKHGYLTIMTDAHKVDPEIDNTEPSEQEARDRVTQLAASHASITTSDWYPLP
                     KVLSMVVPRG"
     gene            complement(7521..9056)
                     /locus_tag="G4Z16_RS31230"
                     /old_locus_tag="G4Z16_31195"
     CDS             complement(7521..9056)
                     /EC_number="6.5.1.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003910 - DNA ligase (ATP) activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0071897 - DNA biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470951.1"
                     /locus_tag="G4Z16_RS31230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31195"
                     /product="ATP-dependent DNA ligase"
                     /protein_id="WP_197353910.1"
                     /transl_table=11
                     /translation="MLLADIARTSREITTVSSRKEKVALLAELFRAASPDEVPVVVTYL
                     AGSLPQRRTGVGFRTLSERHVPSSEAHLTIADVDAALEEIAGVRGKGAQTERKRLLAAL
                     MSAATEEEQHFLFRLLTGELRQGALDAFAVEGLAEAVSVPAGQVRRAVMFGGSLGAVAS
                     ALLAEGPSALEAFRLETGRPVQPMLAQSAKNVLEAVDKLGPCAVEEKLDGIRVQVHKDG
                     TSVGIYTRTLDDITARLPELSEVVGGLAAQQAVLDGEVIALDEQGRPRPFQEVSQRVGS
                     HVDVPTARVTLPVTPRFFDVLSVDGRDLVDLDAAQRHDALAQVVPESLRVRRMVVQDPQ
                     ADEERRAAEEFAQRVLEEGHEGVMVKALDSAYSAGRRGASWLKVKPVFTLDLVVLAAEW
                     GHGRRTGRLSNLHLGARWPDGSFAMLGKTFKGLTDDLLAWQTEHLRGIAEREHSWGVTV
                     RPELVVEIAVDGLQRSTRYPAGVTLRFARVVRYRPDKPASEADTVDDVLALQR"
     misc_feature    complement(9016..9029)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            complement(9160..9504)
                     /locus_tag="G4Z16_RS31235"
                     /old_locus_tag="G4Z16_31200"
     CDS             complement(9160..9504)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986619.1"
                     /locus_tag="G4Z16_RS31235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31200"
                     /product="DUF3140 domain-containing protein"
                     /protein_id="WP_246531165.1"
                     /transl_table=11
                     /translation="MSDMKQQDQHDALFADFAKAVNLPAGQLERWLETERSRNVGRHKG
                     QRESHGHAAGRRIVKLLRTPRADFTADDLVHMRKAIHHIDRQLKRRPRGDISETDWRFA
                     LMNWGHDPQR"
     misc_feature    complement(9531..9542)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    9752..9766
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.18"
                     /tool="antismash"
     gene            10001..11155
                     /locus_tag="G4Z16_RS31240"
                     /old_locus_tag="G4Z16_31205"
     CDS             10001..11155
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.4"
                     /locus_tag="G4Z16_RS31240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31205"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_197353911.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.1e-47, bitscore:
                     160.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRRPSAHVREGNQDVRDVRTLGIDPDQDTAAVIEALLSRHIAVR
                     REEAARSSDRFAEDVIDLLADVVLRGGRRTRPAFVWWGWRGAGGAPRGAGAEAVLKVAT
                     ALELIQGCALIHDDLMDGSLLRRGAPAAHVAFANQHRAAGLRGNPDAFGVSAAILAGDL
                     ALVWADDLYETSGLDSRARRAVGPAWQAMRTETIAGQYLDLYGQGTGVDSPEESLRVAY
                     LKSGLYTVERPLHLGAAMAGADPDLIAALRRAGRSAGVAFQLRDDLLGVFGGPARTGKP
                     AGDDIRDGASTYLVAIALQRARAHGRHDAEQQLRAALGNRELHADELQRIRELLTGLGA
                     VAAVEARIGRLTASALTALDQANLAPPADQRLSSLVRSVSAPPA"
     gene            11378..11914
                     /locus_tag="G4Z16_RS31245"
                     /old_locus_tag="G4Z16_31210"
     CDS             11378..11914
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019354686.1"
                     /locus_tag="G4Z16_RS31245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31210"
                     /product="DNA starvation/stationary phase protection
                     protein"
                     /protein_id="WP_197355044.1"
                     /transl_table=11
                     /translation="MSQQEGGDVIRLLTMRLHALNDLALTLKHIHWNVVGPHFIAVHEM
                     LDPQVDSVRKMTDTTAERISTLGGSPHGTPGALVAERQWEDYAIGRAEAIEHLGALDLV
                     YTGVIEDHREAVRATEETDLITQDMLIEQLRDLELFQWFVRAHLESAGGVLSTSSARSE
                     RDAASKAGKQARKQP"
     gene            11961..12407
                     /locus_tag="G4Z16_RS31250"
                     /old_locus_tag="G4Z16_31215"
     CDS             11961..12407
                     /NRPS_PKS="Domain: Polyketide_cyc2 (3-146). E-value:
                     1.6e-13. Score: 43.2. Matches aSDomain:
                     nrpspksdomains_G4Z16_RS31250_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073573.1"
                     /locus_tag="G4Z16_RS31250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31215"
                     /product="SRPBCC family protein"
                     /protein_id="WP_197353912.1"
                     /transl_table=11
                     /translation="MAGQFEVTTEIDRPIEEVFAFLADGENDPKFSPRVLEMAKVTEGP
                     TGVGTVYRSTVKDAGVRTRREFRITEFEVPTRIRWTETSENLVTAEEGGYDLERSGDST
                     TRVRLFNSLTGHGVGKMIAGVALNAARKDADDFGRRIKQAAESA"
     aSDomain        11970..12398
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G4Z16_RS31250_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.60E-13"
                     /label="G4Z16_RS31250_Polyketide_cyc2.1"
                     /locus_tag="G4Z16_RS31250"
                     /protein_end="146"
                     /protein_start="3"
                     /score="43.2"
                     /tool="antismash"
                     /translation="QFEVTTEIDRPIEEVFAFLADGENDPKFSPRVLEMAKVTEGPTGV
                     GTVYRSTVKDAGVRTRREFRITEFEVPTRIRWTETSENLVTAEEGGYDLERSGDSTTRV
                     RLFNSLTGHGVGKMIAGVALNAARKDADDFGRRIKQAAE"
     misc_feature    complement(12423..12438)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.34"
                     /tool="antismash"
     misc_feature    12459..12477
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.86"
                     /tool="antismash"
     misc_feature    complement(12480..12494)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     gene            12493..13632
                     /locus_tag="G4Z16_RS31255"
                     /old_locus_tag="G4Z16_31220"
     CDS             12493..13632
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024770.4"
                     /locus_tag="G4Z16_RS31255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31220"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_197353913.1"
                     /transl_table=11
                     /translation="MGGRAVGAKDSRGRRATLQTVADEVGVSRTTVSNAYGRPDQLNKD
                     LRERIFDAARRLGYSGPDATARSLRRGRAGAIGLLFTETLSYAFADPYSVGFLRGVAEV
                     AEASGTGLLLIPMPPRAYGPAGDKDAPVPPGNDDPETAVRNAVVDGFCLYCVPVGHPAK
                     ALIRARGLPMVTTDERDDPSIPYVGIDERASARLAAEHIVRLGHRRVAVMVDQVVAPGT
                     SGPATVEEQLASDCGDLQGRLGGYRDALEEVGVDWRSVRVVAAGRNSRSAAASAAAHFL
                     DVADRPTAVLAIGDVLALGVLDACEQRGLVVGRDISVAGFDDVPEAERARLTTVRQPMG
                     EKGRIAGRLLLEPPEEQKVPRIKLPTELVVRATTGPAPH"
     gene            13776..13985
                     /locus_tag="G4Z16_RS31260"
                     /old_locus_tag="G4Z16_31225"
     CDS             13776..13985
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS31260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G4Z16_31225"
                     /product="hypothetical protein"
                     /protein_id="WP_197353914.1"
                     /transl_table=11
                     /translation="MFPIEGPIVADATRHLAHSALPDAPVVPDPEKPPKVHRSRQTLAR
                     TLRTLADRLEPPRCVDPAFQPRTQ"
     gene            complement(14086..15711)
                     /locus_tag="G4Z16_RS31265"
                     /old_locus_tag="G4Z16_31230"
     CDS             complement(14086..15711)
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019581.4"
                     /locus_tag="G4Z16_RS31265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31230"
                     /product="amidohydrolase"
                     /protein_id="WP_197353915.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.3e-08, bitscore:
                     33.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQNLHELRPVIYRAARILSQQARGGPEPEAIAVAGGRIAATGTA
                     SQLRERFPGAEEVDFGDAALVPGLNDAHIHLAIAAEDLLHLDLSAGAVSSIEDLLGQVR
                     AEAAHAEPGEWIRGSRYDDTKTGPLTRWDLDRAAPGHPVLVVQVAGHWGVANSAALRAL
                     HIDEDSSPPDGGDFGRDADGRLDGRLVERALMNVVYPATARGGASPLPASSPQEKLRGL
                     ARAQRQWHAAGLTSVCDALIAPEDISLLRQARARDELTLRVGMLLSIDHYAAAQALGVG
                     SGFGDDMLRLVGVKAFVDGAIGGRTCLLAEPYADSDGHGLQTTPTEELFSQVRAVHGDG
                     NRIGVHANGDAAIRLVLDAFEAAQREVPRPGLRHRIEHCSIVDAGILKRMRELGAVAVP
                     FAGYVAYHGGALNRWYGPDRAERMFAHRSFLDAGVAVAGSSDYPCGPYQPLLGIQSMVT
                     REGMDDGVPVGATQRISAEEALAVFTLGSAEAEGTGHVKGRLEPGWLADFTVLGEDILT
                     IDPGGIASVPVRATYVGGECVHEA"
     gene            complement(15708..17234)
                     /locus_tag="G4Z16_RS31270"
                     /old_locus_tag="G4Z16_31235"
     CDS             complement(15708..17234)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009070936.1"
                     /locus_tag="G4Z16_RS31270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31235"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_197353916.1"
                     /transl_table=11
                     /translation="MSSSAAIATTIFGLAMVATLAVGLLSARGRDKGLAEWSVSSRGLG
                     VLFIWLLMAGETYTSFSFLGTAGWSFSMGVPILYLVAYLTTGFAVAYVVGPALWTYASR
                     HQLISIADMAEHRFRSRPLGILVAVVATVFIVPYIQVQIQGMGVVVNAMTYGSIDLRVA
                     AVISFVVAEVFILVSGLRGSAWVSALKDVLVIAVVVFLAVYVPVHFVDGLGDLMHRMVT
                     EKPEWLTFPGHESGGLDGTWFVTTLLLNAVTITIFPTTVAGYLSASSPNALRRNAVLLP
                     WYQLLLFIPMMVGATALFVVPNLKNPDLALFSLVTDALPAPLVAVIGVAGALSAIVPMS
                     VFMLAIGTLWGRTLLGGGNGADPRGRRSGTEPADDMRTKRLSQLVCLLAGLLALAGSLF
                     FPNTLVQLSVLSYEGLAQLVPAVLLALYWRRMPASAAAAGMLVGLTVMTLLWATGNDPL
                     NGINGGVIALAANLAVTGAVTALRPATGGPPAPTERAGAASPAPAAGEAP"
     gene            complement(17231..17617)
                     /locus_tag="G4Z16_RS31275"
                     /old_locus_tag="G4Z16_31240"
     CDS             complement(17231..17617)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023183.4"
                     /locus_tag="G4Z16_RS31275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31240"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_197353917.1"
                     /transl_table=11
                     /translation="MSDSLSDAEQVGAGRPARLPFRALPAANRRRRSLWLLLVPGVLYC
                     AAPVVANSIEPRILGVPFLLAWIIMASVVSPPIIWVAARLDPAYRSDALEPIPADDVPG
                     AVADGADGDGPAAGGLRGTAGGAA"
     gene            complement(17687..18487)
                     /locus_tag="G4Z16_RS31280"
                     /old_locus_tag="G4Z16_31245"
     CDS             complement(17687..18487)
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (14-183). E-value: 2.8e-09.
                     Score: 29.1. Matches aSDomain:
                     nrpspksdomains_G4Z16_RS31280_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982341.1"
                     /locus_tag="G4Z16_RS31280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31245"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_197353918.1"
                     /sec_met_domain="adh_short_C2 (E-value: 3.8e-33, bitscore:
                     114.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYADLFRLDGRRVAVVGGASGIGRESVRALAAQGAEVLVADKDV
                     RGAEETARLAATEPPAPGSRTGPVSVHFLDVLDDDAVREAVAGWGVLDGLVVTVGANVR
                     KRIADYTLADFERVVALNLRAYLSLVQSVAPAMAERGRGSVVGLTSMRAFQVEAGQSVY
                     AASKAGLVQFLRTAAAEWGPRGVRFNAVAPGVVRTPLTDQIAADPQWYDAYAQASALGR
                     WAGAEEIAGAVTYLVSDASTFVTGSVLSVDGGWTAVDGRYEPSV"
     aSDomain        complement(17939..18445)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G4Z16_RS31280_PKS_KR.1"
                     /evalue="2.80E-09"
                     /label="G4Z16_RS31280_PKS_KR.1"
                     /locus_tag="G4Z16_RS31280"
                     /protein_end="183"
                     /protein_start="14"
                     /score="29.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="AVVGGASGIGRESVRALAAQGAEVLVADKDVRGAEETARLAATEP
                     PAPGSRTGPVSVHFLDVLDDDAVREAVAGWGVLDGLVVTVGANVRKRIADYTLADFERV
                     VALNLRAYLSLVQSVAPAMAERGRGSVVGLTSMRAFQVEAGQSVYAASKAGLVQFLRTA
                     AAEWGP"
     CDS_motif       complement(18368..18442)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_G4Z16_RS31280_0001"
                     /evalue="4.10E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="G4Z16_RS31280"
                     /protein_end="40"
                     /protein_start="15"
                     /score="19.4"
                     /tool="antismash"
                     /translation="VVGGASGIGRESVRALAAQGAEVLV"
     gene            complement(18520..20004)
                     /locus_tag="G4Z16_RS31285"
                     /old_locus_tag="G4Z16_31250"
     CDS             complement(18520..20004)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020663516.1"
                     /locus_tag="G4Z16_RS31285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_31250"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_246531166.1"
                     /sec_met_domain="Aldedh (E-value: 7.9e-129, bitscore:
                     428.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNASPAPGPPAPVVSLPEGLTDSLPVGEEWVPAALSEPVRFPYDG
                     SEVAPAPVGDEALARRAAEHAAGLRRRIAKMPTRVRRQVLAGVAAALEEVAGGMEDLLV
                     LETGKPRADCRTEVVRAIATWEAAAGEVFHVHGETVPLDGLPSGDGMTGYWTRRPVGVV
                     VGVAGFNYPMMLASHKIAPALAAGCPVIVKPAPATPLATLWLVRLVREQLVAAGAPAGA
                     VQLVTGDAAVGEALTTHPEVAAVSFTGSAGIGHRIARQAAPRKVVLELGSNAALVVAAD
                     ADLDAAADAVVRGGLYASGQACISVQRVIAVEKVAGELERRIAERLPHIVVGDPREEET
                     RVSALIDEAATERVCSWIKRARAAGARVVHGGTRSGRCITPTLLTGVPDGEPAWDEEIF
                     GPVICLRAVPDLEAAYATVNASRYGLHAAVFTRDLGSAFDAVEELEAGGVVINEVPGYR
                     CDIAPYGGVKDSGTGREGPRFAIEEMTVTRMAVFRR"
     misc_feature    complement(20432..20446)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.9"
                     /tool="antismash"
ORIGIN
        1 cccggcacgc ccggcctctc ccagggccag aagttcaaga agcacggcat ccgcgcctcc
       61 cacaccgccg aggtcgtcct cgaggacgta cgcctccccg gcagctgcct gctgggcggg
      121 aaggagaagc tggacgagcg cctcgcccgg gcgcgcgagc gcgccaagaa gggcggcgag
      181 cgcgtgaaga acgcggccat ggcgaccttc gaagcgtccc ggccgtcggt tggtgcgcag
      241 gccgtgggca tcgcccgcgc cgcgtacgag gtcgcgctcg actacgcgaa ggaacgcgtc
      301 cagttcgggc gccccatcat cgacaaccag ggcgtcgcct tccagctggc cgacatgcgc
      361 acccgcatcg acgctgcccg cctgctggtg tggcgcgcct cgtggatggc ggcggcgggc
      421 aagccgttcg actccgccga gggctccatg tcgaagctct acgccggcga gacggcgaag
      481 acggtcaccg cccaggccat gcagatcctc ggcggcaacg gttacacacg cgaatacccc
      541 gtcgagcgga tgcacaggga cgcggccatc tacaccatct tcgagggcac cagcgagatc
      601 cagcgcctgg tcatcgcccg tacgctctcg ggcgttccca tccgctgagg gtcgaagggc
      661 cggacggcac cggccggctg tcgtgagagg cctttccggg cgagcccgga gaggcctctt
      721 cgtcacgagc gccacagcac gacgagcggg cccggcggac cgcgcgccgg atgcccgggg
      781 ttcgccggtg cttccggtca ggacgcgtcg cccggcggga tcgacggcat gtcgccgctc
      841 cggaggtccg gtcgccggtc gacctgcccg atgcctttcc agtacgtgac cgcggggcac
      901 gtgggagccg ggcgcggcgg agtggccggt caccgctttg cgaaggccgt gacgtccaca
      961 ccgggacgac ttcaggctgc ctgaatccgc gtcggccagg actccgcgga cgcataccgg
     1021 gtcgcgcgcc tgtgggtccc cggcggtgcg agagtgggga acggaccgca ttgccacatc
     1081 gatccggagg ccggacccat gaccctcacg ctcggcggcg gaccgctcgc atcgcggtcc
     1141 ccgcagaccg tcaactacac gatcgacggc cctgcacacc ggctgctgtg gcagcacttc
     1201 ccgcgccgag tacgtgcgct gctgggcagc agcacgctgc tggactccac cgacgccaag
     1261 ctcctgcacg agagcaacct gctgccgcag ctctacgtcc ccttcgccga tctgcgcgag
     1321 gaggtgctgg aggagagctc ccacagcacc cactgcccct tcaaggggga cgcccgctac
     1381 tggagcgtgc gcgtggggga ccgcttcgtc gagaacgccg tgtggagcta ccccgagccg
     1441 ctggacggcg cggagtggct gaagggccac gcggccgtgt actggtcggc catggacgcc
     1501 tggttcgacg aggacgagga ggtcagcggc catgtgcgcg acccgtacca ccgcatcgac
     1561 gtacgtccca ccagccgcca cgtcgtggtc agggccggcg gcaccgacgt cgccgagagc
     1621 cgccgcgcgt tcctgctctc cgagacgggt ttgcccaacc gcttctacct gccgcagcag
     1681 gacgtgcgcg cggagctgct cagcccgagt gccacccaca cgcactgtcc ctacaagggc
     1741 caggcctcct accggacgct ccgcaccgcc gacggcgtca tcgaggacgc ggcctggtgc
     1801 tacgagcagc ccttggacga ggccacgcgc atcgcggggt atttgtgctt cctcgcggac
     1861 ggcgtcgaga ccgtcgtgga cggcacgccc ctgagctaag gcccggcgcg tcaggctcac
     1921 aaccccggtg gacgcagggc gcggggggag atatcgggtc cgtgacgcgc ccggtgtgcg
     1981 caggtgcggc gtgctttcac ggatacccgc gcgccaggcc gccgccgggc ccacaatgcc
     2041 gggatgggga agatctacga acgcatcgac gagcggctcc gtgccttcat cgaggagcag
     2101 cacatcttct tcaccgcgac cgccccgctg gcggccgacg ggcatgtcaa cgtctcgccg
     2161 aaggggctcg ccgggtcgtt cgccgtcctt gacgacgtca ccgtcggata tctggatctc
     2221 ggcggcagcg gagccgagac catcgcccat ctgcgtgaga acggccgcgt caccctgatg
     2281 tggtgcgcct tcgacgggcc gccccgcatc gtgcgcatcc acggcaccgg cgtgcccgtc
     2341 ttccgcgacg acccgcgctg gcaggaactg ctcccgcact tcgacgtcag catgcagagc
     2401 cgcacggacc tgcgtgccgt catcaccgtg cgcgcggagc gcatcagcga cacatgcggt
     2461 ttcgcggtgc cgttcatgga tcacaaagga gaccggcagc tgcacacgca gcgcttcgcg
     2521 cgcgagaccg acgagtcctt ctccagatac tgcgagaaga aggagcacgt cggtgtcagc
     2581 ctcgacggtc tgcccgccct gcccctgcct cttcccagac gcatccgctg acatctcccg
     2641 ccgcacgacc cgcggaaaca cccgcactcc gtcaaccccg agccgagcgg accggcccgt
     2701 cggtctgctc accccaggag catcagcatg agcagcagtg cacacatcgg cgtcaccggc
     2761 ctcgccgtca tgggccgcaa cctcgcccgg aacttcgccc gcaacggata caccgtggcc
     2821 ctgcacaaca ggaccgtctc caggacgcgt gacctcgtgc gcgacttctc cgacgaggga
     2881 agcttcatcg ccgcggagac cgcggaggag ttcgtcgccg ccctggagcg gccgcggagg
     2941 ctggtgatca tggtgaaggc gggagccccg accgacgccg tgatcgacga gttcgccgcg
     3001 ctgctcgaac ccggcgacgt catcatcgac ggcggcaacg cccactacgc cgatacgcgg
     3061 cgtcgcgaga aggcgatgcg cgaacgcgga ctccacttcg tcggtacggg catctcgggc
     3121 ggcgaggaag gcgccctgca cgggccgagc atcatgcccg gcggctccgc cgaggcctac
     3181 gactcgctcc gcccgatgct ggagagcatc gccgccaagg ctcccgacgg cacgccctgc
     3241 accacccacg tgggcccgga cggtgcgggc cacttcgtga agatggtgca caacggcatc
     3301 gagtacgccg acatgcagct gatcggcgag gcttaccacc tgctgcgcga cgtcgccgga
     3361 tacagccccg accgcatcgc cgagaccttc cgcgagtgga acaccggccg cctggactcc
     3421 tacctcatcg agatcaccgc ggaggtcctc tcgcactccg acggcgccac cgggcagccc
     3481 ttcgtcgacg tcgtcgccga cgaggccgag cagaagggga ccggccgctg gaccgtgcag
     3541 accgcgctcg atctgggagt gcccgtctcc ggcatcgccg aggccgtctt cgcccgctcc
     3601 ctctccggcc atgccgacct gcgctcggcc agctcccatc tggcgggtcc cgctgccgct
     3661 gcgctctccc cggacgacgc cgagcggttc gcggggcagg tcgaacaggc cctgtacgcc
     3721 tcgaagatca cgtcgtacgc acagggctgg aacatgatca gcagcggcag ccaggagtac
     3781 ggctgggaga tcgacccggg tgccgtcgcc gccatctggc gtgcgggctg catcatccgt
     3841 gccgtgttcc tggaccgcat ccgtgccgcg ttcgccggcc ggcccgatct gccgacgctg
     3901 ctggcggacg agcacttctc caaggagatc ggcgatgcgc agggcgactg gcgcacggtc
     3961 gtggccaccg cggtgcagca cggcatcccc gtgcccggtt tctccgccgc gctcgcctcg
     4021 tacgacagcc tgcgcagtgc acgcctgccc gcctctctca cccaggggca gcgcgacttc
     4081 ttcggagcgc acacctaccg gcgcaccgac cgggacgggt ccttccacac gctctggggt
     4141 ggggaccgca gcgagttgtc cgcggactga ccacacgtgg cacagccagg tttgcgcagg
     4201 ccggagacgg gtgtgcgtcc cggtacggac ggagagcggg gaggggagtg gtggccgcgc
     4261 gagcgggcac ccggtccttg acggatatgc cgctacgtaa atccggagtt gtgatgccac
     4321 agcagtcagg cacgaggttc ccggtctgca ggcggccaga cccggttcct cccaacccca
     4381 ctccgccgcc cgggcccggt gggccggggc ccggaccggc accggatccg gtgccggcgc
     4441 cgacgcccgc ccctccgccg ggacccgcac cggatccgat tccgccgtct cccacgccgg
     4501 agccggtccc gccggagccg gaaccgcagc ctgcgccgcc ggcgccgtga cgcccacgcc
     4561 gcaggcagag aacgggcccg cgtaggcggg cacggcacaa ggccgtgggc agacaggtga
     4621 aaccccttcc cacctgccgg cccacggcct caggtgtgcc cggggcggca tgggtccgca
     4681 gacacgccgc cgcacctgca ccggaaccct agtgacaggc gcggcggact ccgctcagag
     4741 ctcgatcgcc caggccagga agtagatgaa gaagacggcg acgagcagcg ccaggatgat
     4801 caccggcgtc ttcgcccagc ccttggccgg gttgtggcgc tcgtccggac ctgcgcccgc
     4861 cgtgctgtcc tcgccgggag gcgtctcccc gggcggcacc tgcccgcccg gttccagacc
     4921 gggcgtgtgg cgagggtcct cggggtcggg gtacttctcg tccatgccgc ccgggtgggc
     4981 agcgagccgc gacctatacc tgccgggcgg cgattttcgc cgccaccgcc gtggtctcag
     5041 tccgtcaggc ctgtcacgcg tagcgtgagg ttgagcctcc cggacgccat ccccgtggcc
     5101 ggatcgcccg tgccggggaa gaccttcgtc acgccgtggt acgcgaaacg ggacgggccc
     5161 ccgaagacga acaggtcgcc ggaggagaga tgcaggtccg tgtagggcct gctccgcgat
     5221 tcggtgttcc cgaagcggaa gacgcaggtg tcgccgatgc tcagcgagac gaccggcgcc
     5281 gccgacctct cgtccttgtc ctggtgcatg cccattcgtg cgctgccgtc gtagaagttg
     5341 atcagggccg tgtcgggctc gtactcgcgg gcggccgcgt cgtccccgta cgcgtcggcg
     5401 agcgcccgct ggccgagccg ggccagccac tcggggaatc cggccacgcg gagcccgttc
     5461 acgtcgtcgg cggtgcgcgt gtagcgatag ggctgccagt gccatcccag gcagaccgtc
     5521 tgcaccgaca tcacgccgcc gcgcgggagt ttcgtgtgcc gcagcggcac ggggccggcc
     5581 gcccatgccc ggcaggcgga gacgaggtcg cgctgctcct ggaggccgag ccatccgggc
     5641 aggtgcaccg ccccgggcgc cgggcgcgac gggggagcgg ggatgagtgc gtccactcgc
     5701 gacctcctgt gacgacggcg ccgtacggac ctaccgccgg ccacgctgcc acgggtgcgt
     5761 gccgaccggc accggcaagt gtcccagccc ctgccgacac cgcccggcgg ccaccggaca
     5821 cgaagctgcg gtgcccacgg gtgcccacgg ggaaagccct gcgtacgggc ccgggatgcg
     5881 ggcagaagga ggggacacga cgaccgacaa ggggagatca tggagatctc aggcatcatc
     5941 agcgccatcg tgatcgggac catcatcggt gtgctggggc ggctcatcgt gcccggacgt
     6001 cagcgggtcg gcattttcct gacgatcggg gtcggcatcg tggccgcact cataggctcg
     6061 gccatcgcca cgtacttcgg ggtgggtgac accaacggag tcgactggat cgagtggctc
     6121 atacagctgg ttctggcagc actcggtgta tcggccctgg accgctcgaa gcgccgccgc
     6181 cgctgagcgg caccgtcaac tcgcccgatc ccggggcccc ttgccgggcc aggcatcccg
     6241 gcgaggggcc ctcatgctcg acgtcctgaa ctctcccgct ctccgcactt tcgccgcgca
     6301 ccgtacccgc ggcacgcgaa tcgctctacg ctgatgctca cttggacccc ccacaccacc
     6361 aaggactcag cccatgagca gatcccgcct agccgtcgcc atatcgacgg ccgctctggt
     6421 caccgctgcc acggcgctcg ccattcccgt caccgcccag gcgggccccg agaaggccgc
     6481 cgcccccacc tacggcgaca ccacgagcgt cggtgtgcac aacgcctacg agcaggacaa
     6541 gtacgagtac ttcgcggacg cgctcgactc gggcgcctcc ctcctcgaac tcgacgtgtg
     6601 gaccaacgtc atcggcaagg gctggcgcgt ctcccacagc aacccgaccg gcaacgacaa
     6661 caactgcgag aacgcggcgt cggcggacga actgcgcacc aaggaacgcg accagagcct
     6721 cgacggctgc ctcgcagaca tgcgcgcctg gcacgacgcg caccccggcc acccgcccgt
     6781 cctcatcaag gtcgagatga aggacggctt ctacgacaag gcggaccgcg gcccggacga
     6841 actcgactca ctgctcagcg agaagctggg cgacgcgctc tttcgtcctt ccgacgtcac
     6901 cggatcgcac gccaacctcg acgaggcggt gggcagcacg ggctggcccg accgggacgc
     6961 catggcgggc aagttcctct tcgaactcat cccgggcacc gtcgaggagg acaacccagc
     7021 cgacgacctg tggacggacg aggagtacgc cacccacctc aaggatctct ccgccaaggg
     7081 cgcactgggc gaggccggcg ccttcccggc ggtccacggt gccgagaagg gcgatccccg
     7141 gaccgagcgc tacgacgagg ccctgcggcc ctggttcgtc gtcttcgacg gcgacgccgc
     7201 cacgttcgcg gggggcggga tcgacaccgc ctggtatcag aagcacggct atctcacgat
     7261 catgaccgac gcacacaagg tcgacccgga gatcgacaac accgagccga gcgagcagga
     7321 ggcccgggac cgcgtcactc aactcgccgc ctcgcacgcc agcatcacga cctccgactg
     7381 gtacccgctg ccgaaggtcc tctcgatggt ggtcccgcgc ggctgaacgg cgcctgccgc
     7441 ggccgctgtt cgtcgccgcg ccccggtcat ccgcgccgcc gatgcggtgc ggatgtaccg
     7501 ccgtcctcgc gcttcgcccg ctaacgctgg agcgcgagga cgtcgtcgac cgtgtcggcc
     7561 tccgacgccg gcttgtcggg ccggtagcgc accacgcggg cgaagcgcag cgtcacaccg
     7621 gccggatacc gcgtggagcg ctgcagcccg tcgacggcga tctccaccac cagttccggc
     7681 cgcaccgtca cgccccagga atgctcgcgc tccgcgatgc cgcgaaggtg ctcggtctgc
     7741 caggccagca ggtcgtccgt gagccccttg aaggtctttc cgagcatcgc gaacgatccg
     7801 tccggccatc gcgcgcccag atgcaggttc gacagccgtc ccgtgcggcg cccgtggccc
     7861 cactccgcgg caagcaccac cagatcgagg gtgaagacgg gcttcacctt cagccacgag
     7921 gcacccctgc gtcccgcgct gtaggcggaa tcgagcgctt tgaccatgac gccctcatgc
     7981 ccctcctcca ggacccgctg cgcgaactcc tcggccgcgc ggcgctcttc gtccgcctgc
     8041 ggatcctgga ccaccatgcg ccgcacccgc agggactccg gtacgacctg cgcgagagcg
     8101 tcgtggcgct gtgccgcgtc caggtccaca aggtcgcgtc cgtcgacgga gagcacgtcg
     8161 aagaagcgcg gcgtgaccgg cagcgtcacc cgcgccgtcg gcacgtccac gtgcgagccc
     8221 acacgctggg agacctcctg gaacggacgg ggccggccct gctcgtccag ggcgatcacc
     8281 tcgccgtcca gcaccgcctg ctgagcggcc aacccgccca cgacttccga gagttcgggg
     8341 agccgggcgg tgatgtcgtc cagggtgcgc gtgtagatgc ccacgctggt gccgtccttg
     8401 tgcacctgca cccggattcc gtcgagcttc tcctccaccg cgcacgggcc gagcttgtcg
     8461 acggcctcca gcacgttctt cgcgctctgc gccagcatcg gctgcacggg gcgtcccgtc
     8521 tccagacgga acgcctccag cgccgacggt ccttcggcca gcagagcgct cgcgaccgcg
     8581 ccgagcgagc ccccgaacat caccgcacgt cgcacctgac ccgcagggac cgagaccgcc
     8641 tccgcgaggc cctccacggc gaaggcgtcg agcgctccct gccgcaactc acccgtgagc
     8701 agccggaaga ggaagtgctg ctcctcctcg gtcgccgcgg acatcagcgc cgccagcagc
     8761 cgcttccgct cggtctgggc gcccttgccg cgcacaccgg cgatctcctc cagcgcggcg
     8821 tccacgtccg cgatcgtcaa gtgcgcctcg gacgagggca catggcgctc ggagagggtg
     8881 cggaagccaa cacccgtccg gcgctgcggc aggctgcccg ccaagtacgt gacgaccacc
     8941 ggcacttcgt cgggcgaggc cgcgcggaac agctccgcca gcagcgccac cttctccttg
     9001 cgcgaggaga cggtcgtgat ctccctcgag gtccgggcga tgtcggcgag cagcatgact
     9061 ccatcctcgc tccgccgccc ccgcctcgca gcaccacgga cgagggggtt ccggcttccg
     9121 ggccgttccc ggcatcccgg gcgggcccgt cgactgccgt cagcgctgcg ggtcgtgccc
     9181 ccagttcatg agggcgaagc gccagtccgt ctcgctgatg tcgccccgcg ggcggcgctt
     9241 gagctgccgg tctatgtggt ggatcgcctt gcgcatgtgg acgaggtcgt ccgcggtgaa
     9301 gtccgccctg ggggtccgca gaagcttcac gatgcgacgt cccgccgcgt gcccgtgact
     9361 ctcgcgctgc cccttgtggc ggcccacgtt gcgcgaccgc tccgtctcca gccaccgttc
     9421 gagctggccc gcgggcagat tcacggcctt cgcgaagtcg gcgaagagcg cgtcgtgttg
     9481 gtcctgctgc ttcatgtcgc tcatgagtcg caccccccac tggcgccggg gcgttcctgt
     9541 ccgcctgtcg tcccggagga acccgtcggc tttctgccga cccggtcggc agtggcggga
     9601 acgaccgcaa cagcggcgtc cgtacgggcc accgtgcgcg tgccttcggc gatcttgcga
     9661 cggaccctgc cgagtaccgc gtttccctga gtcctccagt gcggccggtc gcgccctggg
     9721 atcgttctgc ccctcgacat ggatgtacga cgcctttcag atgattcatg gctttcgtcc
     9781 tacgagtgcc ctcccagctg cggtgaatgc ctgtgcttcc cgtgcccggc atcggaccgc
     9841 gcggcgttgc acaccccgta cggccgtgcg gcaggcgcac ggcgcggagg tgcagccggg
     9901 agccatggct gaaaaactcg tcgtacatct tccttcaccg tccgtgagcg cgaatgctcc
     9961 tgcctgcgct gccgggccga actctcggga aggagccgcc atgcagcgcc ggccgagcgc
    10021 ccatgtacgc gaggggaacc aggacgtccg ggacgtccgc acgctcggca tcgaccccga
    10081 ccaggacacg gcggccgtca tcgaggcgct gctgtcccgg cacatcgcgg tccgccgcga
    10141 ggaggccgcc cgcagcagcg accggttcgc cgaggacgtc atcgacctgc tcgccgacgt
    10201 ggtcctgcgc ggcggcaggc gcacccggcc cgccttcgtg tggtggggat ggcggggcgc
    10261 cgggggtgcg ccgcgcggag ccggcgccga ggccgtcctc aaggtcgcca ccgccctgga
    10321 gctgatccag ggctgcgcgc tcatccacga cgacctgatg gacgggtcgt tgctgcgcag
    10381 gggcgcgccc gccgcgcacg tcgccttcgc caaccagcac cgggccgcgg gcctgcgcgg
    10441 caaccccgac gcgttcggcg tctccgccgc catcctcgcg ggcgacctcg cgctggtgtg
    10501 ggcggacgac ctgtacgaga cctccggact cgacagcagg gcgagacggg cggtcggacc
    10561 cgcctggcag gccatgcgaa ccgagacgat cgccggacag tacttggacc tgtacgggca
    10621 gggcaccggc gtggactcgc ccgaggagtc actgcgggtg gcctatctca agagcggcct
    10681 ctacacggtc gagcggccac tccacctggg cgcggccatg gcgggcgccg accccgacct
    10741 catcgccgcc ctccgccggg ccggccgcag cgccggcgtg gccttccagc tccgcgacga
    10801 tctcctcggc gtcttcggtg ggcccgcccg cacgggcaaa cccgcgggcg acgacatcag
    10861 ggacggcgcc tccacttatc tggtggccat cgcgctgcag cgggcccgcg cacacggcag
    10921 gcacgacgcc gagcagcagc tgcgtgccgc gctcgggaac cgggaactgc acgcggacga
    10981 actccagcgg atccgggaac tgctcaccgg cctgggcgcc gtcgccgccg tcgaggcccg
    11041 catcggccgc ctcaccgcgt ccgcgctcac cgccctggac caggcgaacc tcgcgccgcc
    11101 ggcggaccag cggctcagct cgctcgtacg gagcgtctcg gcgccgcccg cctgatcgcg
    11161 tcccccgaag ccgcccgcac acgccggcag gtgtgggcag gggcagcggg gagtcacccc
    11221 taccgaatgg aggactcggc gggctcccgg cgcgcgtgag ggagtgagcg gtgttggcat
    11281 ggggagaagc cgccgacccg gggcgggccg tccatgccga gagggagaga gagccgtgcc
    11341 caggagcgca cccgaaccga agtacacggt ccccggcatg tcccagcagg agggcggcga
    11401 cgtcatccgg ctgctgacca tgcgtctgca cgctctcaac gacctcgccc tgacgctcaa
    11461 gcacatccac tggaacgtcg tcggcccgca cttcatcgcg gtgcacgaaa tgctggatcc
    11521 ccaggtcgac tccgtacgta agatgaccga cacgacggcg gagcgcatct ccaccctcgg
    11581 cggctcgccg cacggcaccc cgggtgctct cgtggccgag cggcagtggg aggactacgc
    11641 catcggccgt gccgaagcca tcgaacacct cggcgctctg gacctcgtct acacgggggt
    11701 catcgaggac caccgggagg cggtgcgtgc caccgaagag accgacctga tcacgcagga
    11761 catgctcatc gagcagctgc gcgacctcga actcttccag tggttcgtcc gcgcgcacct
    11821 ggagagcgct ggcggtgtgc tgagcacatc gagcgccagg tccgaacggg acgccgcgag
    11881 caaggccggc aagcaggccc ggaagcagcc ctgagcggct ttgccgccgc gagggagcga
    11941 tcagaggcag gggagagacg atggccggac agttcgaggt gaccacggag atcgatcgcc
    12001 ccatcgagga ggtcttcgcc ttcctcgccg acggtgagaa cgaccccaag ttcagcccca
    12061 gggtgcttga gatggccaag gtgaccgagg ggccgaccgg agtcggcacg gtctacagga
    12121 gcacggtcaa ggacgccggg gtgcgcaccc gccgggagtt ccgcatcacg gagttcgagg
    12181 tgcccaccag gatccgctgg acggagacct cggagaatct cgtgaccgcg gaggagggcg
    12241 gctacgacct ggagcggtcc ggcgactcca ccacgcgtgt gcggctcttc aactcgctga
    12301 ccggtcacgg cgtcgggaag atgatcgcgg gcgtcgccct gaacgccgcg cgcaaggatg
    12361 cggacgactt cggccggcgc atcaagcagg ccgccgaatc ggcctgaaca agcccctgtc
    12421 gcgaaaaaaa gaagtggaca gccgctgccg cgcccggcta ctgtatcgat acagacttaa
    12481 tcgatacaga agatgggtgg gcgagcggtg ggggccaagg actcgcgcgg taggcgggcg
    12541 acgctgcaga ccgtcgcgga cgaggtcggg gtgtcgcgta cgaccgtctc caacgcatac
    12601 ggccgccccg accagctcaa caaggacctg cgcgagcgga tcttcgacgc cgcgcggcgc
    12661 ctgggctact ccgggcccga cgcgacggcg cgttcactgc ggcgggggag ggcaggagcg
    12721 atcggcctgc tcttcaccga gaccctctcg tacgccttcg ccgacccgta ctccgtgggc
    12781 tttctgcgcg gagtcgccga ggtcgccgaa gcctccggca ccggcctgct cctcatcccc
    12841 atgccgcccc gtgcctacgg cccggcgggc gacaaggatg ctccggtgcc gcccggcaac
    12901 gacgatccgg aaacggccgt acgtaacgcg gtggtcgacg gtttctgcct ctactgcgtc
    12961 cccgtgggcc atcccgccaa ggcgctgatc cgggcacggg gcctgccgat ggtgaccacc
    13021 gacgagaggg acgatccctc gatcccgtac gtcggcatcg acgaacgggc ctcggcgcgg
    13081 ctcgccgcgg agcacatcgt ccggctcggt caccggcggg tcgcggtgat ggtcgatcag
    13141 gtcgtcgcgc cgggcacctc gggccccgcg accgtggagg agcaactcgc ctccgactgc
    13201 ggggacttgc agggccgcct cgggggctac cgggacgcgc tggaggaggt gggagtcgac
    13261 tggcggagtg tccgcgtcgt cgccgcgggc cgcaactccc gctccgcggc ggcctccgcg
    13321 gccgctcact tcctcgatgt cgccgaccgg cccaccgccg tgcttgcgat cggtgacgtg
    13381 ctcgcgctcg gggtgctcga cgcctgcgag cagcggggcc tcgtcgtggg ccgggacatc
    13441 tccgtcgccg ggttcgacga cgtccccgag gcggagcggg cccgcctgac caccgtgcgc
    13501 cagcccatgg gggagaaggg acgcatcgcc ggccgcctgc tcctcgaacc gccggaggag
    13561 cagaaggtgc cccgcatcaa gctccccacc gaactggtcg tacgggccac caccggtccc
    13621 gcaccccact gacccggccg gcacagatcg ccgtcaactc cgattcccag cccaccaccg
    13681 attccggccg atccggtcct gccggcctgt ccggccgcac tcacctcacg ggccgcaccg
    13741 gcccgtgccg caccgctcat cagtcaggag aggaaatgtt cccgatagaa ggccccatcg
    13801 tcgcggacgc caccaggcac ctggcccact ccgcgctgcc cgacgcaccc gtcgtcccgg
    13861 acccggagaa gccgccgaag gttcaccggt cgcggcagac gctggcccgg acgctgcgta
    13921 ccctcgccga ccgtctggag cccccgcgct gcgtggaccc ggcgttccag ccgcgcaccc
    13981 agtgagggcg ggcaggcggg ggaagcagca gggccggacg gacccccgtg gtccgtccgg
    14041 ccctgcccga tcggcctcgt cctgccgccg gttccgcgtc ggcgttcacg cctcgtggac
    14101 gcactcaccg cccacgtagg tcgcccgtac aggcactgag gcgatgccgc cggggtcgat
    14161 ggtgaggatg tcctcgccca ggacggtgaa gtcggcgagc cagcccggct ccagacgccc
    14221 cttcacatgg ccggtgcctt ccgcctcggc cgacccgagc gtgaagaccg ccagcgcttc
    14281 ctccgcgctg attcgctgcg tcgctccgac cggcacaccg tcgtccatgc cctcgcgggt
    14341 gaccatcgac tggattccga gcagcggctg gtaggggccg cacggatagt cggacgaacc
    14401 cgccaccgcg acaccggcgt ccaggaagga gcggtgcgcg aacatccgct cggcgcggtc
    14461 cgggccgtac cagcggttga gcgcaccgcc gtgataggcc acgtaacccg cgaacggcac
    14521 cgcgaccgcg cccagttcac gcatccgctt caggatgccc gcgtcgacga tgctgcagtg
    14581 ctcgatgcgg tgacgcagtc ccggtcgcgg cacctcccgc tgcgccgcct cgaaggcgtc
    14641 gaggacgaga cggatcgcgg cgtccccgtt cgcgtgcaca ccgatgcggt tgccgtcgcc
    14701 gtgcacggcg cggacctggg agaacagttc ctcggtgggc gtcgtctgca gtccgtggcc
    14761 gtccgagtcc gcgtagggct cggccagcag gcaggttcgc ccgccgatcg caccgtccac
    14821 gaacgccttc acgccgacga gccgcagcat gtcgtcgccg aagccgctgc cgacacccag
    14881 cgcctgcgcg gcggcatagt gatcgatcga gagcaacatg ccgacgcgca gggtcagttc
    14941 gtcgcgtgcc cgtgcctgcc gcagcagaga gatgtcctcg ggagcgatca gggcgtcgca
    15001 cacggaggtc agtcctgccg cgtgccactg ccgctgggcg cgagccaggc cgcgcagctt
    15061 ctcctgcggt gagctggccg gcaggggtga agcgccgccg cgggccgtgg cgggatagac
    15121 gacgttcatc agcgcccgct cgacgagccg cccgtcgagg cgtccgtccg cgtcccgccc
    15181 gaagtcgccg ccgtcgggag gggaggaatc ctcatcgatg tgcagggcgc gcagcgccgc
    15241 ggagttggcg actccccagt ggcccgcgac ctgcacgacg agcacgggat gcccgggagc
    15301 cgcccggtcc aggtcccagc gggtgagcgg gccggtcttg gtgtcgtcgt agcggctgcc
    15361 gcgaatccac tccccgggct cggcgtgcgc cgcctcggcc cgtacctgtc ccaggaggtc
    15421 ctcgatgctg gagacggccc cggccgacag gtccagatgc agcaagtcct cggcggcgat
    15481 ggcgagatgg atgtgcgcgt cgttgagacc cggcacgagc gccgcgtcgc cgaagtcgac
    15541 ctcctcggcg ccggggaagc gctcccgcag ctgcgatgcc gtgccggtgg cggcgatccg
    15601 tccgccggcg acggcgatcg cctccggttc cgggccgccg cgcgcctgct ggctgaggat
    15661 gcgggcggcg cggtagatca ccgggcgcag ttcgtggaga ttctgggtca cggggcctcc
    15721 ccggcagcgg gtgcgggact cgccgctcct gcccgctcgg ttggagcggg cggtccgccg
    15781 gtggcgggac gcagcgcggt gacggcgccg gtcacggcga ggttcgccgc cagcgcgatg
    15841 acgccgccgt tgatgccgtt gagtgggtcg tttccggttg cccacagcag cgtcatcacc
    15901 gtcagcccca ccagcattcc ggcggcggcc gcggaggcgg gcatgcggcg ccagtacagc
    15961 gccagcagta cggcgggaac cagttgcgcc agcccctcgt aggacagaac ggacagctgg
    16021 accagggtgt tggggaagaa caggctcccg gccagcgcca gcagccccgc caggaggcac
    16081 accagctggg agagccgctt ggtgcgcatg tcgtcggccg gttccgttcc gctgcggcgg
    16141 cctcgcgggt cggcgccgtt tccgccgccc agcagggtgc ggccccacag cgtgccgatg
    16201 gccagcatga acacgctcat cggcacgatc gccgagagag cgcccgccac accgatcacc
    16261 gccaccagcg gagccggcag agcgtcggtg acgagtgaga acagagccag gtccgggttc
    16321 ttgaggttcg gcacgacgaa cagtgccgtc gcgccgacca tcatcgggat gaacagcagc
    16381 agttggtacc agggcagcag aacggcgttg cgccgcaggg cgttcgggga gctggcactc
    16441 agatagccgg cgaccgtcgt cgggaagatc gtgatggtga cggcgttcag caggagggtc
    16501 gtgacgaacc acgtgccgtc gaggccgccc gactcatggc cggggaaggt gagccactcc
    16561 ggcttctccg tcaccatccg gtgcatcaag tcgcccagtc cgtcgacgaa atggacgggc
    16621 acgtacacgg cgaggaagac caccaccgcg atcaccagga cgtccttgag ggcactgacc
    16681 cacgccgagc cgcgcagacc ggacaccagg atgaacacct cggcgacgac gaaggagatc
    16741 accgcggcca cgcgcagatc gatgctcccg tacgtcatgg cgttgaccac cacgcccatg
    16801 ccctgaatct gcacctggat gtaggggacg atgaagaccg tggccaccac ggcgacgagt
    16861 atccccaatg gccgggaacg gaagcggtgt tcggccatgt cggcgatcga gatcagctgg
    16921 tgccggctcg cgtacgtcca cagggcgggc cccaccacgt acgcgacggc gaagcccgtc
    16981 gtcagatacg ccaccagata caggatcgga acacccatgg agaacgacca gccggccgtg
    17041 cccaggaacg agaagctggt gtaggtctca ccggccatca gcagccagat gaacagcacg
    17101 cccagtcccc ggctggagac cgaccactcc gccaggccct tgtcccggcc gcgcgcgctg
    17161 agcaggccca cggcgagggt cgccaccatc gccagcccga agatcgttgt cgctatcgcg
    17221 gctgacgaac tcatgccgca ccacccgccg ttccgcgcag tccgccggcg gcgggcccgt
    17281 ccccgtcggc gccgtcggca accgcgccgg gaacgtcgtc cgcgggtatg ggttccagcg
    17341 cgtccgaccg gtacgccgga tcgagccggg ccgcgaccca gatgatcgga gggctgacga
    17401 cggacgccat gatgatccac gccagcagga acggaacccc gaggatgcgc ggctcgatgc
    17461 tgttggccac gacgggtgcc gcgcagtaca gcacaccggg caccagcagc agccacagcg
    17521 aacggcggcg ccggttcgcc gcgggcagtg cacggaaggg cagccgggcc ggccggcccg
    17581 cgcccacctg ctccgcgtct gagaggctgt cggacatatc tctccttctg tgcgctgcct
    17641 gtgctgctgt tcgctcactc gggtcccggg ccgccgccgg aaccggtcat acggacggtt
    17701 cgtagcgtcc gtccaccgct gtccagccgc cgtccacgga cagcacgctg ccggtgacga
    17761 acgtcgaggc atcggagacg agatacgtca cggcacccgc gatttcctcc gcgcctgccc
    17821 agcgtcctag ggccgacgcc tgggcgtagg cgtcgtacca ctggggatcg gcggcgatct
    17881 ggtccgtcag cggggtacgc accacacccg gcgcgacggc gttgaagcgc accccgcgcg
    17941 gtccccactc cgcggcagcg gtacgcagga actgcaccag gcccgccttc gaggccgcgt
    18001 acacgctctg ccccgcctcg acctggaagg cccgcatcga tgtcaggccc accacgctgc
    18061 cgcggccgcg ctctgccatc gcgggtgcca ccgactgcac gagcgacaga tacgcgcgga
    18121 ggttcagcgc gacgacccgc tcgaagtcgg cgagcgtgta atcggcgatc ctcttgcgca
    18181 cgttggcgcc gacggtgacg acgagtccgt ccagcacgcc ccacccggcc acggcttccc
    18241 gcacggcgtc gtcgtccagc acatcgagga aatgcacgct gacggggccc gtgcgggatc
    18301 cgggcgcggg cggctcagtg gcggccagcc gcgccgtctc ctccgcgccc cgcacgtcct
    18361 tgtcggccac gagcacctcg gcgccctgcg ctgccagcgc ccgcaccgac tccctgccga
    18421 tgccgctggc gccgccgacc accgccaccc gcctgccgtc gagacggaac aggtccgcat
    18481 accgcaccct ggcctcctct gccgtcccgc gtgcggcggt caccggcgga acaccgccat
    18541 ccgcgtcacc gtcatctcct cgatggcgaa ccgcggcccc tcgcggcccg tgccggagtc
    18601 cttcacgccg ccgtacggtg cgatgtcgca gcggtagccg ggcacttcgt tgatcaccac
    18661 accgccggcc tccagctcct cgacggcatc gaaagccgag cccaggtccc gggtgaagac
    18721 cgccgcgtgc agcccgtagc ggctggcgtt gaccgtcgcg tacgcggcct ccagatccgg
    18781 cacggcccgc agacagatca ccgggccgaa gatctcctcg tcccacgcgg gctcgccgtc
    18841 gggcacgccg gtcagcagcg tcggcgtgat gcaccggccg ctgcgcgtac cgccgtgcac
    18901 gacccgtgcg cccgccgcgc gggcacgctt gatccaggag cacacgcgct ccgtggccgc
    18961 ctcgtcgatg agcgcggaga cgcgcgtttc ctcctcgcgc ggatcaccga cgacgatgtg
    19021 cggcagccgc tccgcgatcc tccgctccag ctccccggcg accttctcca cggcgatcac
    19081 ccgctgcacg gagatgcacg cctggcccga ggcgtagaga ccgccgcgca cgacggcgtc
    19141 ggccgccgcg tcgagatcgg cgtccgcggc cacgaccagc gccgcgttgg agcccagctc
    19201 cagaacgacc ttgcgcggcg ccgcctggcg cgcgatgcgg tgcccgatcc cggcggaccc
    19261 ggtgaaggag accgcggcga cctccgggtg cgtcgtgagc gcctcgccca ccgcggcgtc
    19321 accggtgacc agctgcaccg caccggccgg tgcgcccgcg gccaccagct gttcccgtac
    19381 gagacggacc agccacagcg tggccagcgg cgtcgccgga gcgggcttga cgatgaccgg
    19441 acagcccgcc gcgagcgccg gggcgatctt gtgcgaggcc agcatcatcg ggtagttgaa
    19501 cccggcgacg cccacgacga cgccgacggg acggcgcgtc cagtaccccg tcatgccgtc
    19561 tccggagggg agcccgtcca gcggaaccgt ctcaccgtgc acatggaaga cctcgccggc
    19621 cgcggcctcc cacgtggcga tcgcccgcac cacctcggtg cggcagtccg cgcggggctt
    19681 gcccgtctcc agtacgagca ggtcctccat gccgccggcg acctcctcca gcgcggcggc
    19741 gacaccggcg aggacctgcc tgcgcacccg cgtcggcatc ttggcgatcc gcctgcgcag
    19801 ccccgcggca tgctctgccg cccgccgcgc gagggcctcg tcgccgaccg gggccggagc
    19861 gacctcgctg ccgtcgtacg ggaagcgcac cggctcgctg agggcggccg gcacccattc
    19921 ctcgccgacg ggaagcgaat cggtcagacc ctccgggagc gagaccaccg gcgcgggagg
    19981 gcccggagcg ggggaggcgt tcaccgcggg ccccccttcg ttccggccgt caggaagtgc
    20041 cgggccgctg ccgcgtagac cctcgcgtac tcgccgatct ccgccacctc gacgtactcg
    20101 tccttctggt gcgcgatcca cttgccgccc ggcccgtaga ccaccgtcgg caggcctgcg
    20161 tcacgcgtga ggatggtgcc gtccgtggtg ccggggaccg cgccgatggc gggctccgag
    20221 ccgtgctcgt cgcggtgccc ggccatcagc gccgtgacca cgggatggtc ctcgtcgatc
    20281 tcgacggcgg gccggtcgtc gacgacggtc agttcgacgg tcacacccac ggtgccggcg
    20341 acgtcggcgg ccgcctgtcg caccctggtg atcagctcgt cgtggtcggt ccccgggacc
    20401 gtacgcacat cgacgccgac catgccgtgc gcgggaatga cgttcagctg gcccgggtct
    20461 cccgcgtgca gcacggtcgg agtgaccgtc acggagccgg cgtgccggtg cttgccgaag
    20521 cgccgcaccg cccacgcctc cacaccggcc agcgcctcga tgatccgcgc cccggcgacc
    20581 aggggagacc gtgcctcctg cggcatcgcg ccgtgtgcca tcacccccgt gagatcgagg
    20641 cggatgcgga tgccgccgcg ggccgaggtg cacacctcgt agccttcggg ctcgcacacg
    20701 atgacgccgt ccacctcggc cgcggccggt gacgcggcga acgccttggc gccgagcatc
    20761 atctcttcct cgtcgcacag cacgcccagc acgatccggc cggggaacgg acccgccagc
    20821 tgcagccccc gcacgccgtg gatcatcgcc gccagacccg atttcatgtc ggccgagccg
    20881 cgcccccaca gcctgccgtc gcggatctcc ccgccgtacg gatcgacgct ccagtcctcc
    20941 gtgcgcccct ccgtcacgac gtcggtgtgg ccctcgaaca tcagcgtcgg cccgtcgccg
    21001 ccgcctccct cgacgacggc cacgaggttc gtgcggcccg gcgcgacctc gatcacctcg
    21061 tgctcccagc cgaactccgt gaacaggccc gcgagaaggc ggacggccgg accttcgacg
    21121 tcctgcgccc ccgcgtcgct caccgtgcgc agccg
//
