LOCUS       NZ_CP048882            20621 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces bathyalis strain ASO4wet chromosome, complete genome.
ACCESSION   NZ_CP048882
VERSION     NZ_CP048882.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces bathyalis
  ORGANISM  Streptomyces bathyalis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Rohde,M., Schumann,P., Hahnke,R.L.,
            Sproer,C., Bunk,B., Kampfer,P., Schupp,P.J. and Wink,J.
  TITLE     Streptomyces bathyalis sp. nov., an actinobacterium isolated from
            the sponge in a deep sea
  JOURNAL   Antonie Van Leeuwenhoek 114 (4), 425-435 (2021)
   PUBMED   33595745
REFERENCE   2  (bases 1 to 7377472)
  AUTHORS   Risdian,C., Landwehr,W., Schupp,P. and Wink,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-FEB-2020) Microbial Strain Collection, Helmholtz
            Centre for Infection Research, Inhoffenstrasse 7, Braunschweig,
            Niedersachsen 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-FEB-2019
            Assembly Method                   :: HGAP v. v3
            Assembly Name :: Streptomyces_DSM106605_HGAP3_1SC_10M
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 117.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_015910445.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 04:35:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,467
            CDSs (total)                      :: 6,387
            Genes (coding)                    :: 6,276
            CDSs (with protein)               :: 6,276
            Genes (RNA)                       :: 80
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 111
            CDSs (without protein)            :: 111
            Pseudo Genes (ambiguous residues) :: 0 of 111
            Pseudo Genes (frameshifted)       :: 37 of 111
            Pseudo Genes (incomplete)         :: 90 of 111
            Pseudo Genes (internal stop)      :: 12 of 111
            Pseudo Genes (multiple problems)  :: 25 of 111
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5851518
            Orig. end                         :: 5872139
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048882.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from MISG, Helmholtz Centre for
            Infection Research, Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20621
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="linaridin"
                     /region_number="22"
                     /rules="(cypemycin or cypI)"
                     /tool="antismash"
     cand_cluster    1..20621
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cypemycin or cypI)"
                     /kind="single"
                     /product="linaridin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20621
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10621](+)"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10621
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
     misc_feature    194..207
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.28"
                     /tool="antismash"
     gene            complement(744..1436)
                     /locus_tag="G4Z16_RS25330"
                     /old_locus_tag="G4Z16_25310"
     CDS             complement(744..1436)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955593.1"
                     /locus_tag="G4Z16_RS25330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_25310"
                     /product="hypothetical protein"
                     /protein_id="WP_197352955.1"
                     /transl_table=11
                     /translation="MFKHGLRRRVALLASATALLLPLGVAQAGAVTPATARTASAEAPI
                     PGAYISPWGSADVEISPETQQGLQREGVTLEAISPFTMHSDGKGFSMPIGSTAGDGLDS
                     KGRIYYPGGLRLHHAESGQTATLKPTWIRVMPQPAYSAGVEVDGQTVSEETQLGYSNYY
                     EVMKGARPSPTGFRLEKMPFYFSQEAEDLIEANSDIDAPDGGTPFGTLTPHFDYIPGQQ
                     PTLPGLPG"
     gene            1941..3422
                     /locus_tag="G4Z16_RS25335"
                     /old_locus_tag="G4Z16_25315"
     CDS             1941..3422
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007456311.1"
                     /locus_tag="G4Z16_RS25335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_25315"
                     /product="DUF4331 domain-containing protein"
                     /protein_id="WP_197352956.1"
                     /transl_table=11
                     /translation="MPLFRRPWATGPSRRRIALITGATVVAGAAMSGPLLSVSQAGGHV
                     DAPSSLADAAADITDVYAFTSPDDHDMVTLIANVRPFQLPGNATSSVADHPFANGARYE
                     INTDADGDGTPDTTYRWTFANDDRRPLKAGPKVGPGQVTSLDDRSLRVRQTYTLERVRK
                     GAKPETLIGKGVAAPTHAGRALMPDYGKLREEAVRQLPGGGRTLAGQSAEAFKADSEVF
                     GLYTVGTAGPVRGWLPDAQPLSALNVNSLIVQVPKKAIALRKDPQANPVVGVWASVSRP
                     GADLSRGLSGQDPVFRQVSRHGNPHLAFSIFGSTVGMARPGGPEDRFQQRDPEDDHLER
                     DFLAAVNDPKPPHRIERAHHVKAPATPRKDIEALFLRGIGEDNGAKFGYDLNTPAMNAD
                     ADPSKIVPAEELRLNLTTPVTRNPKPNGLIDGDRQGFPNGRRLNDTIDGPLIRMLMGEP
                     GGPSAEHLLPTPDFKLQPADAQYTFPYLNPPHAAL"
     gene            3604..4761
                     /locus_tag="G4Z16_RS25340"
                     /old_locus_tag="G4Z16_25320"
     CDS             3604..4761
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955595.1"
                     /locus_tag="G4Z16_RS25340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_25320"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_246531060.1"
                     /transl_table=11
                     /translation="MDTAPRDPGVWSELAHAEIEKARTTLDAGRLDAAGKALRRSLTLK
                     RTGNYPATTGMGQLANARHEFTTGRRWGLRSTRMAPDRAEGYGVLADAEIQLGHYRGAR
                     VAVQRMLDLKPTTAAYSRAAYDLETHGRDQDAAFALQRAAESAQTPDEMAFAESRLGEL
                     AWSQGELRRAERHFERATATVPDHPYSAAGLARLQAARGHPAEALRMYDRLVERTPLPQ
                     FLLEATELRLARPGRRDRGALAGLKAQARMLRATGGPVDPHLALYEADHGDSATAVALL
                     RREWKRSRSVIVADALSWALHRSGRDAEALTYARAAARTGWKNALFRYHRGVIEYRLGQ
                     DTAGDHHLRQALQLNPHFSPYHAPRAARLLHRRDCATAEEHGDRR"
     gene            4758..6290
                     /locus_tag="G4Z16_RS25345"
                     /old_locus_tag="G4Z16_25325"
     CDS             4758..6290
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611530.1"
                     /locus_tag="G4Z16_RS25345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_25325"
                     /product="nickel transporter"
                     /protein_id="WP_246531061.1"
                     /transl_table=11
                     /translation="MIQRSRTPLRVLVTMVLVLLISVGAAPGTHAHPLGDFSLNHHDGL
                     RLSSGHIEDTAVVDSAEIPTAQDREKTDTDNDGDVSRSEATNRARQRCSRLAEASRVTV
                     NSRRKEWRVRASRLTYGKGTAGLPIARLTCRLRTDADLSRAAAITFASGADRRRTGWKE
                     ITATGGNRVRLTASSAPERSASAGLRRYPSGAADEPPNQTTASLRTRPGDDRPSTGTDD
                     AAPGAGPSAAAGTSLFPSLERELTALTTSRDLTLPVGLLGVMLTVLLGAGHAALPGHAK
                     LAVAACLARRTGGVRAALTVGVTVTATHTTGVLIVGLALTLSGSLLGDQLLGWLGTISG
                     LLIATIGAWLVITAVRALNTGRPPTSWQHRHHHHHRSHDHAHEYSHSHSHEHPRARDEE
                     HRTDLRLPSLLGVGLAGGLVPSPSALVVLLGAVSLSRTFFGVLLVLGYGLGMAATLTAA
                     GLLLSGGGNRLTTLAERRLPAWSRYTRFGTLLTALAVLTVGLALTLRSLPPL"
     gene            <6370..6597
                     /locus_tag="G4Z16_RS32735"
                     /pseudo=""
     CDS             <6370..6597
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003887303.1"
                     /locus_tag="G4Z16_RS32735"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS630 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="TASS"
     gene            complement(6594..7256)
                     /locus_tag="G4Z16_RS25350"
                     /old_locus_tag="G4Z16_25330"
     CDS             complement(6594..7256)
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017530.4"
                     /locus_tag="G4Z16_RS25350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_25330"
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_197352957.1"
                     /transl_table=11
                     /translation="MTLDEQVVLLSIDARGRFPEPWRTDCAAAGAVLLELALAGRLDVD
                     DHKVVVADRTPVGSAVLDDVLAVLAAREKRATAQSWVRELRKSVRGKALDRLRERGTVG
                     EEVSRTLGLFTTRRYPTLDSSVEVALRDRLDGVVLRGETPDERTVGLAVVLSAAGLYEC
                     AFPGVPARDVERRTAKLARDNWAAPAVRRALEAMQYELVAVVGAATVGAATVGAGTS"
     gene            7514..7705
                     /locus_tag="G4Z16_RS25355"
                     /old_locus_tag="G4Z16_25335"
     CDS             7514..7705
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS25355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G4Z16_25335"
                     /product="hypothetical protein"
                     /protein_id="WP_197352958.1"
                     /transl_table=11
                     /translation="MLLEKVNNSHLLDTVLTDAANVEDMSPAEPVLSTPAAVAGGALVT
                     AGAFGAGVGLGVTQAQAG"
     gene            7760..7972
                     /locus_tag="G4Z16_RS25360"
                     /old_locus_tag="G4Z16_25340"
     CDS             7760..7972
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS25360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G4Z16_25340"
                     /product="hypothetical protein"
                     /protein_id="WP_197352959.1"
                     /transl_table=11
                     /translation="MTAISTKVNASQELNGVSIHAGENEWNGRMSPVLATPAAVGAGLA
                     GAAAIAGAAAGGIAVGNAAGQAAGG"
     gene            8077..8949
                     /locus_tag="G4Z16_RS25365"
                     /old_locus_tag="G4Z16_25345"
     CDS             8077..8949
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS25365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G4Z16_25345"
                     /product="hypothetical protein"
                     /protein_id="WP_197352960.1"
                     /transl_table=11
                     /translation="MNISSAARRSLSSPVIGRERALTTAEQLSATAYLMSSLEILAAER
                     DRQKGGLNNWDLARDNYTWAPPKVRASLDFLARPDVTRWIHGARALASASLLVPGTSRR
                     HRAAANGFLALTSVATYPRHHYGTDGSDQLSFLVQSAAMIARLGQRQPALVDSCLWYVA
                     LQATLSYATSGYVKIASPIWRSGEALPGIMRTETYGDGKVYDLMKRYPKASRKLAHAVL
                     AMECAFPAVFLAKGRLTPAMLAGLGSFHVVNARVMGLSRFVWAFLATYPAILYVTQSRE
                     STKPGGGSR"
     gene            8946..10001
                     /locus_tag="G4Z16_RS25370"
                     /old_locus_tag="G4Z16_25350"
     CDS             8946..10001
                     /NRPS_PKS="Domain: Abhydrolase_1 (74-194). E-value:
                     5.4e-14. Score: 44.3. Matches aSDomain:
                     nrpspksdomains_G4Z16_RS25370_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="G4Z16_RS25370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_25350"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_197352961.1"
                     /sec_met_domain="PF00561 (E-value: 2.4e-09, bitscore: 35.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.3e-19, bitscore:
                     69.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTRITMHPVRNDALPRIAGGLLSAVVATGLTVQQLRHRRVLR
                     GQGDESFFETSTGNVLAYQLTEAEGPDSSPVLVCETGLCSTVEHWIRLRRMLGCDHPVL
                     AYNRAGYGRSEYRLREPFSLAAAVADLSDLVRAVCPSRPVVLVGHSLGGHLTLRAIEPL
                     RDLVTGVVLLDPSHPAELLRSRVQADGANVLTSALALMPESARLGLGSLLTSPPWLRWL
                     PEDMRPLILDQFRDWKLWKATVREWHATHTEFLDHDGVLPKVGVPLRLVAAATTHARDP
                     IHAELHRELVGTSPDGDLCLIEDARHDELVMNERPAAQVAELIREFTIGLRTSGLCTSG
                     LRPTLDAPEVR"
     aSDomain        9168..9527
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G4Z16_RS25370_Abhydrolase_1.1"
                     /evalue="5.40E-14"
                     /label="G4Z16_RS25370_Abhydrolase_1.1"
                     /locus_tag="G4Z16_RS25370"
                     /protein_end="194"
                     /protein_start="74"
                     /score="44.3"
                     /tool="antismash"
                     /translation="PVLVCETGLCSTVEHWIRLRRMLGCDHPVLAYNRAGYGRSEYRLR
                     EPFSLAAAVADLSDLVRAVCPSRPVVLVGHSLGGHLTLRAIEPLRDLVTGVVLLDPSHP
                     AELLRSRVQADGANVL"
     CDS_motif       9363..9410
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_G4Z16_RS25370_0001"
                     /evalue="7.40E-06"
                     /label="NRPS-te1"
                     /locus_tag="G4Z16_RS25370"
                     /protein_end="155"
                     /protein_start="139"
                     /score="18.5"
                     /tool="antismash"
                     /translation="PSRPVVLVGHSLGGHL"
     gene            10001..10621
                     /locus_tag="G4Z16_RS25375"
                     /old_locus_tag="G4Z16_25355"
     CDS             10001..10621
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G4Z16_RS25375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="G4Z16_25355"
                     /product="hypothetical protein"
                     /protein_id="WP_197352962.1"
                     /sec_met_domain="cypI (E-value: 2.6e-32, bitscore: 110.5,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLPRPKSEAIRRAVELGFASWLTITILSQHPNTAFDRLRTADKV
                     GLLIPNWRFFAPTPAQHDYHLLYRTLDTDGEQSAWQSASQINKRKWAHAVWFPGRRQEK
                     AIFDVCGELGRLIVRKDVKVADSAAYRLLRDFVIRHLDESDPRRVSLTGFQFLVVLYSG
                     HDDSEDPQYSFISPFIRLSEPDPTDHAGDADHTGAADQLEHAA"
     gene            10618..11388
                     /locus_tag="G4Z16_RS25380"
                     /old_locus_tag="G4Z16_25360"
     CDS             10618..11388
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604053.1"
                     /locus_tag="G4Z16_RS25380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_25360"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_197352963.1"
                     /transl_table=11
                     /translation="MTKSEAAPQVDDPGYGRRFADFYDKLFPKNAGADAIAEALASMAD
                     GGPALELGVGTGRIAIPLAERIGAVIGVDSSPEMLEELRRDVERAGAPVQAVHGDLRTY
                     EDECSYPLVYLVCGTLSMVLEPQQQRQAVARAAHRVAPGGRLVIENFNTPGILAMSQEG
                     GHFTSFAPYPDPNTGLLTSWLVEKDTGLWQSSHVWFEDNSFRIASDVNRLIPPEEVDRY
                     ASACGLELVHRWSDWQGTAYDERGAMYIAVYEVP"
     gene            11495..13501
                     /locus_tag="G4Z16_RS25385"
                     /old_locus_tag="G4Z16_25365"
     CDS             11495..13501
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991974.1"
                     /locus_tag="G4Z16_RS25385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_25365"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_246531062.1"
                     /transl_table=11
                     /translation="MTATRYTDRRRGRGRHSRKTDRTTWEGTCGKPDSVWTVSLQHRAL
                     LITGMLLGLLGVVASLAQPYAIGKLIETAELDQSLAGPIALLVVLFCADAAFSSLQAYA
                     IGRTGENIVFDVRRNLIERLVRAELTSVNKQPQGDILTRTVTDTSLVKIALSQSLAQLF
                     INGATIIGGVALMFAIDIWLMLITLACLGVASLVSIGLARKLRQVAVQNREDTGAFGTE
                     VQRVLSALPTVKASRAEDRELLRIGQQAHLARTSGIRVNAFNALLMPSMNVGTQAALAI
                     VVGVGMTRVAGGAMSIADLTAFVMYLFHLVSPLVLFFMAIGQFVQGRAAVQRVDGLAAL
                     PQEGQEERVQQPALVGSLIQDRGAIEFHNVRFGYDGQSADANALAGVSFHVPTRGLTAI
                     VGPSGAGKTTLFQLIERFYRLDGGRILLGGQNIEALPLDTVRGLVGYVQQDSATMRGTI
                     RENLTYANPEAAEADIREAVEMAGLSDVIQGLPQGLDTDLGDQGSGLSGGQRQRLCIAR
                     TLLQKPAITLLDEATSHLDSDSERDFRQVLQRISRHCAVVAIAHRISTVIDADQIVVLE
                     NGRVRATGVHDDLMERDDLYRRLAGSQLHAESGLVGEPVIPRLEQQHPAYEAFEYPPQQ
                     LRPDADAFQPQSAEGTSDVQAGQQFPEPVGGTI"
     gene            13498..14976
                     /locus_tag="G4Z16_RS25390"
                     /old_locus_tag="G4Z16_25370"
     CDS             13498..14976
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135440.1"
                     /locus_tag="G4Z16_RS25390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_25370"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_197352964.1"
                     /transl_table=11
                     /translation="MTSADVAVVGTGPNGLAAGVTLARAGLKVELYEAADTIGGGLRTQ
                     PLFEQDVAHDICAAVHPMAAASRFFREFDLATRGVELLHPEISYAHPLEGGRAGLAHHD
                     LAATCTELGPDGERWRTLMQPLLNHSQGVVDLILSGQRTLPRDPSAALALATRIPVHAS
                     RLGAARFATEEAAALLTGVAAHAMGKLPSLASAAVTMLLGHLAHGTGWPLPRGGSARIA
                     RAMAADITAHGGSFHTNCPITSLDQLTSAHTILLDTSVKGLLTLAEDQLPPRYTRRLKR
                     YRYGPAAAKVDFLVTEPIPWANPAVGRAGTVHLGGTHAQMIHQETLTARGIPTQEPFVL
                     LVDPAVTDPGRARPGKRPVWAYAHVPNGDSREPAELVRSRIEHYAPGFTDTILAHRCVT
                     GAGYETYNPNYVGGDIGCGAMTLTQSLARPTLSIDPYRTPLPGLFLCSAATPPGPSVHG
                     MSGYLAAQSALRTRFGITTTPSLAPEPTVAEGMG"
     gene            complement(14984..15958)
                     /locus_tag="G4Z16_RS25395"
                     /old_locus_tag="G4Z16_25375"
     CDS             complement(14984..15958)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018890434.1"
                     /locus_tag="G4Z16_RS25395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_25375"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_197352965.1"
                     /transl_table=11
                     /translation="MAVLGVSAAEEKVYRYFLRNPNTSVEEIHAELNLDKESVPDCVDR
                     LLDLGMLRIIGGCRMIPTDPHTAIARLADQRLGALHSELQQVTGCRQIADSLRTEQSSR
                     TTASCDVEQLTDLAEMRNRIDDLSFFAREEVLSVEPYEELQPESIEYARRLDLRCLRRG
                     IRLHMIVLRAALDHPPTAAYLRELAGQGARIRVVDETTERILAYDRNVAVVPVDPVETS
                     RGALIAHESGLVSSIVALFWRIWEQAEELPARDEESADEALSAATKREVLVAMCSGDKD
                     EAAARSIGVSVRTFRRKVAAVMKHLGADNRAQAALLARERGWI"
     misc_feature    16450..16465
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.2"
                     /tool="antismash"
     gene            17007..19517
                     /locus_tag="G4Z16_RS25400"
                     /old_locus_tag="G4Z16_25380"
     CDS             17007..19517
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="G4Z16_RS25400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4Z16_25380"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_197352966.1"
                     /transl_table=11
                     /translation="MARARQRGASWRQLAVTLDMPAMTLHRQFNSGHGVFAIGQHRGGP
                     APTETNTETGDRQANAAGQPTFADAPATSPGAPPRQQDGDPPAVLDQLVGRERELADLR
                     PLLAKNRLITLTGPGGVGKTRLALECLAKIRASYGGGVRWVNLAPLSDGSLVAPTVASA
                     VLGGSMPNGSVEDAVADGCGSRSALIVLDNCEHVIESCAELVEPLLERCPRLSVLATSR
                     EALQITGETVFPVTPLPVPGSGRGTVARSGAAVQLFVHRARSVQPSFTLTDTMAETVAT
                     VCMRLDGIPLAIELAARQTAFLSPTRLLEDADRRLDLLVGGLRTAPHRHQSLRSAISWS
                     YDLLDAEQQQVFRRMSVLPGGFEEPLATALCAGLGLSGHRMWTLLTALADKSLLVSDQV
                     ATGRFRMLESLRVFGRECLEAADESEEVHERLLAWMADFSERLLLWTSNPAVDLAGQLD
                     RERHNLHYAVTTAERLGDPRTPLLGAALTSCWNRRGVPRQAERLAERLLAAHASPSVGR
                     ACLSTTLSDALCRRGHHADAVAPAEEALGIAQTREHPTLIVRALGALSRVRSCLGEHDV
                     ALEIYQRQVELLRTLEQPTLLAMILNRLAWKLLMIGRADEATGHIEEALSLLDSDNALE
                     ALSATLHTAAGVSITRQRFEEAAQYFTMALTMQSVDAEGKLYNLEGLALVAMTDGQPER
                     GLRLLSTAKTIREKSHLVADAWWNDMVQTAAERARQDLPPARAAAALADGAELSHDEVI
                     RYALHNAWPPGRCDHPDSVLTSRQWQVAELVAQGLTNQQIAARLHISPRTAASHLEAVK
                     IRLNLQTRAHVVTWVAATEHTRKE"
     misc_feature    17628..17630
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18885..18887
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(<19654..>19923)
                     /locus_tag="G4Z16_RS32740"
                     /pseudo=""
     CDS             complement(<19654..19923)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143638.1"
                     /locus_tag="G4Z16_RS32740"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="mobilization protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDGAIAAGIAAGGEVLDALATTSAAHTGRELREAAWPFERASRTH
                     VRAVRGHDRALRQAARGIVHRGRAQPPAAVRTGATTAMVIDMLFF"
ORIGIN
        1 cagcgcgggc cgccaccaaa gcagcagcga aggtccgagc ggtgccaccg tcggcacttc
       61 gctttccact cccgacgctc aggcgggcac gctgcacgag gttgcccagg cgctgccggc
      121 cctggtcacg ggaaccgtcg tcccgcaagg aggcgaagcc ctcgccaacg cacttacctc
      181 actgctgagt tgatcaaccc agatcaattc cggcgagtgg gggcagcgct gaatctggat
      241 gggccggggt tggtgcacag gacatcgaga ggtcggccgg atgctggcgg cgcagggtcg
      301 acgtgagatg cccgcgctgt gcacccgatg tgcaccgacc caccgaacgt cctgcttctg
      361 tgcaggtcag ggctccttcg cagcggtact tcgacatcta aaggcggagg cctgtcatcc
      421 gccttcgacg gcgcgttgct tcggtggccc gcggaaacgc cttccggcgt cttccggcgg
      481 gccaccgcct ttgccgcgct cactgaatcg ttcggctgcg gaccccgggc cgcggccgcc
      541 tgatacaggc acatcaccgg cggcatgttg ccgacgaggt gagaggcggc gggcggacgc
      601 tgcctgaccg accggacggt gcgtcgactg cactgcactg ctaaagatcg tcggatgaag
      661 agcgatactc atgtgtgcac ccgccgccgg tgtgcccgtc ggcgggtgcc gctacatcga
      721 gcctgttgcg gaacaggtac gcctcagccg ggcaggccgg ggagggtcgg ctgctgtccg
      781 gggatgtagt cgaagtgcgg cgtgagtgtg ccgaacggtg tgcctccgtc gggagcgtcg
      841 atgtcgctgt ttgcctcgat caggtcttcg gcctcttgtg agaagtagaa gggcatcttc
      901 tccagacgga agccggtcgg gctggggcgg gcgcccttca tcacctcgta gtagttgctg
      961 tagccgagtt gtgtctcctc ggagaccgtc tggccgtcca cctccacgcc cgcggagtac
     1021 gccggctggg gcatgacgcg aatccaggtc ggcttgaggg tggctgtctg gccggactcg
     1081 gcgtggtgca gccgcaggcc gccggggtag tagatgcggc ccttggaatc gaggccgtcg
     1141 ccggccgtcg atccgatggg catgctgaag cccttgccgt cggagtgcat tgtgaacggg
     1201 ctgatggcct ccagagtgac gccctccctc tgcaacccct gctgggtctc cggcgagatt
     1261 tcgacgtcgg cgctgcccca aggtgagatg taggcgccgg gaatcggtgc ctcggcggac
     1321 gcggtccttg ccgtagccgg cgtgacggcg ccagcttggg cgaccccgag cggcagcagc
     1381 agtgccgtcg cggaggccag cagggcaacg cggcgacgga gtccgtgctt gaacatgaac
     1441 agtgaaccct tccgaaatcg ggacaggtga agcccgtgat ggacggcggc agggccacgg
     1501 catgacggga accgtgaagc cgcctgaaca ggccttcgtg gagctggcgt tggagcactg
     1561 agtcgcaacc accttggccg caaagcggtc cactcgccgg tctgcacagt ccatgagtaa
     1621 gcccccgatg accgcaaagc catagttggt ggggaaacca gctatttcgt gtattgctct
     1681 cgtcttcccg gcctgccgca agggacagcg agcccatcga aaccgctgca cagaggcact
     1741 ttcggcgagg gcatccccga aggcctccgc acacccgtgc ttgacggtcc gtcaatgcgt
     1801 tgcgagccgg gtcagtcctc gcggtgcagt aggtacctca cacgtgtggt gcccggcaga
     1861 gaacagcccg gcaagatccg gcagcgcgac acgctgtggc tccggatggc gtcctcaaca
     1921 cctcaacacc tggagcactc atgcccttgt tccgcaggcc ctgggccacc ggcccgagcc
     1981 gtcgccggat cgctctcatc acaggtgcga ccgtcgtggc cggcgccgcc atgtcaggtc
     2041 cgctcctgtc cgtcagccag gccggcggtc atgtcgacgc cccctcgtcg ctggccgacg
     2101 cggcggccga catcaccgat gtctacgcct tcaccagccc cgacgaccac gacatggtca
     2161 ccttgatcgc caacgtccgt ccgttccagc tgccgggcaa cgcgaccagc tcggtcgccg
     2221 accatccgtt cgccaacggg gcccggtacg agatcaacac ggacgccgat ggcgacggaa
     2281 ctccggacac cacctaccgc tggaccttcg cgaatgacga ccgcaggccc ctcaaggcag
     2341 gtcccaaggt cgggcccggc caggtgactt cgctggacga ccgttccctg agagtccggc
     2401 agacctacac gctggagcgc gtccggaaag gagcgaagcc cgagacgctc atcggcaagg
     2461 gcgtcgccgc ccccacgcac gccggccggg cactcatgcc cgactacggc aagctgcgcg
     2521 aggaggccgt ccggcaactg cccggcggcg gacgcacctt ggccgggcaa tcggctgagg
     2581 cattcaaggc ggattccgaa gtgttcgggc tctacaccgt cggcacggcc gggccggtac
     2641 gcggctggct gcccgacgcc cagcccctgt cggctctgaa cgtcaacagc ctgatcgtcc
     2701 aggtgcccaa gaaagcgatc gcgttgcgca aggatccgca ggcaaatccg gtcgtgggtg
     2761 tatgggcctc ggtctcccgt ccgggcgcgg acttgagtag gggcctgtca ggacaggatc
     2821 cggtgttccg tcaggtctca cggcacggca acccgcacct ggcgttcagc atcttcggtt
     2881 cgaccgtggg gatggcccgc cccggtggcc ccgaggaccg cttccagcag cgtgaccccg
     2941 aggacgacca cctggagcgg gacttcctcg ccgcggtgaa cgacccgaag ccgccgcacc
     3001 gcatcgaacg ggcccaccac gtcaaggctc ccgccacacc gcgcaaggac atcgaggctc
     3061 tgttcctgcg cggcatcgga gaggacaacg gggcgaagtt cggctacgac ctcaacacgc
     3121 ccgccatgaa cgccgacgcc gacccgtcga agatcgtccc ggcggaggaa ctgcggctga
     3181 acctcaccac ccctgtgacg aggaatccga agcccaacgg cctcatcgac ggcgacaggc
     3241 agggcttccc caacgggcgc cggctcaacg acaccatcga cgggcccctg atccgcatgc
     3301 tgatgggcga gcccggaggc ccatccgccg aacacctgct gccgaccccg gacttcaagc
     3361 tccagcccgc cgacgcgcaa tacaccttcc cctacctcaa tccgccgcac gcggcactgt
     3421 gagggccgtg tgaagagctg gggcgcggcc gtcggcgtga cctgcgccat cggagcctgt
     3481 gtcgcgggac tgctggccat ggggccggcc ggattcaacg acgacgttcc gtctccgagt
     3541 ccgcgcaccg cgcaccgggc gggcgctggg gcagacgatc ctctctctgc ggcgcgccgg
     3601 gcggtggaca cggcaccgag agacccgggc gtctggtcgg aattggcgca cgcggagatc
     3661 gaaaaagccc gcaccaccct ggacgccggg cgtctggatg cggccgggaa ggcgctgcgc
     3721 cgctcgctca ccctgaagcg cacgggaaac tacccggcga ccacgggcat ggggcaactc
     3781 gccaatgcgc ggcacgagtt caccacaggg cgcaggtggg gtctgcgcag cacacggatg
     3841 gcacccgacc gggccgaagg ttatggggta ctcgccgacg ccgagatcca gctcgggcac
     3901 taccgcggtg cccgggtggc cgttcagcgc atgctcgatc tgaagccgac gactgccgca
     3961 tacagtcgcg ccgcctacga ccttgagacc catggccgcg accaggacgc cgctttcgct
     4021 ctccaacgag ccgccgagag tgcccagaca cccgacgaga tggccttcgc cgagtcccgg
     4081 ctcggcgaac tggcctggtc acaaggtgaa ctgcggcgtg ccgaacggca cttcgagcgc
     4141 gccacggcca cggtgccgga tcatccctac tctgcggccg ggctcgcccg gcttcaggcg
     4201 gcacgcgggc acccggcgga ggcgctcagg atgtacgacc ggctggtcga acggacgcca
     4261 ctgccgcagt tcctgctgga ggcgacggaa ctgcggctgg cacggcccgg tcgacgggac
     4321 aggggcgcac tcgcggggct gaaggcgcag gcgcggatgc tgcgtgctac gggcggcccc
     4381 gtcgatcccc accttgcgct gtacgaggcc gaccacgggg actcagcaac cgcggtcgca
     4441 ctgctgcgac gcgagtggaa gcgttcgcgc agcgtcatcg tcgctgacgc gctcagctgg
     4501 gcgctgcacc gctccggacg tgacgccgag gcactgacct acgccagggc cgcggcccgc
     4561 accgggtgga agaatgcgct cttccgttac caccgagggg tgatcgagta ccggctcggg
     4621 caggacaccg caggcgatca ccacctacgg caggcgctcc agctcaaccc gcacttctcg
     4681 ccgtaccacg ctccccgcgc cgccaggctg ctccaccgac gcgactgcgc gaccgccgaa
     4741 gagcacggtg accgccggtg atccagcgtt cccgtacccc gctccgcgtc ctcgtgacga
     4801 tggtcctcgt gctgctgatc agcgtcgggg cggcgcccgg cacgcacgcc catcctttgg
     4861 gcgacttcag cctcaaccac cacgacggac tgcggctgtc ctcggggcac atcgaggaca
     4921 ccgccgtcgt cgacagcgcg gagatcccaa ccgcccagga tcgcgagaag accgatacgg
     4981 acaacgacgg cgacgtctcc cggtccgagg ccaccaaccg cgcccggcaa cgctgctccc
     5041 gactcgccga agcctcccgg gtgacggtca acagccgtcg caaggaatgg cgcgtgcgcg
     5101 ccagccgcct cacatacggc aaaggaacag ccggtctgcc gatcgcccgg ctcacctgcc
     5161 gcctccgcac cgacgccgat ctctcacggg cggcagccat cacgttcgcc tcgggtgcgg
     5221 accgacgtcg taccggctgg aaggagatca ccgccacagg cggaaaccgg gtgcggctga
     5281 cggcatcgtc cgctccggaa cggagcgcga gcgcgggact gcgccgctat ccctccggcg
     5341 ccgccgacga gccgccgaac cagaccacgg caagcctgcg cacgcggccc ggcgacgacc
     5401 ggccctccac cggcacggac gacgccgcac ccggcgcggg cccctccgcc gcagcgggta
     5461 cctccctctt cccctctctg gagcgggagt tgaccgcact caccacaagc cgcgacctca
     5521 cccttccggt aggacttctc ggtgtcatgc tcaccgtcct cctgggcgca ggtcacgccg
     5581 ccctgcccgg acacgcgaaa ctcgccgtcg cagcatgcct cgcccgccgt acgggcggcg
     5641 tccgagccgc cttgactgtc ggcgtgaccg taacggccac acacaccacg ggcgtgctga
     5701 tcgtgggcct cgcgctgacc ctctccggca gcctgctggg agatcaactg ctgggctggc
     5761 tgggcacgat cagcggcctg ctcatcgcga ccatcggtgc atggctggtc atcacggccg
     5821 tacgcgccct caacaccggc aggccgccga cgagttggca gcaccggcac caccaccacc
     5881 accgttcgca cgatcatgcc catgagtaca gccacagcca cagccatgag catcctcgcg
     5941 cccgagatga agagcaccgc acggacctcc gcctgccctc cctactcggc gtcggactcg
     6001 ccggaggact cgtgccgagc ccttcagccc tggtcgtact gctcggtgcc gtctccctca
     6061 gccgcacctt cttcggcgtc ctgctcgtcc tcggctacgg actcggcatg gcggccaccc
     6121 tcaccgcagc cggtctgctg ctctccggcg gcggcaaccg cctcaccaca ctcgctgagc
     6181 gacgccttcc cgcatggtcc cgctacaccc gattcggcac actcctcacc gcactcgccg
     6241 tcctcaccgt cggactcgcc ctcaccctgc gcagcttgcc gccgctgtga catcgagcgc
     6301 ggcaacagga agccgcccag gatcgacaag ctcgcccgcg ccggcgcacg ttcttcgcgt
     6361 tccgacggaa cggcatcgtc gtagctgaac atggtggagc ggtggttcgc cgagctgacg
     6421 cagaagaagc tgaaacgtgg cgtgcaccgc tccgtccagg cccttgagcg cgatatccga
     6481 acgtggctcg ccgactggaa cgacagcccc agaccgttcc tctggacgaa aaccgccgac
     6541 gagatcctcg aaagagtcgc cgcatactgc caacgaatct ccgactcagg tcactagctg
     6601 gtgccggcgc ccacggtcgc ggcgcccacg gtcgcggcgc ccacgacggc gacgagttcg
     6661 tactgcattg cctccagggc cctacgtact gcgggagcgg cccagttgtc acgtgccagc
     6721 tttgccgtgc gccgttcgac gtcccgggcc ggcaccccgg ggaaggcgca ctcgtacaaa
     6781 ccagcagcac tcagcacaac cgccaagccg acggtgcgtt catccggtgt ctcaccccgt
     6841 agcaccacac cgtccaaccg atcgcggagc gcgacctcta cggagctgtc gagcgtgggg
     6901 tagcgacgtg tggtgaacag ccccagcgtc ctgctcacct cctcgcccac tgtccccctc
     6961 tcccgaagcc ggtccagtgc cttaccgcga acgctcttac ggagctcacg cacccagctc
     7021 tgcgcggtgg cccgcttctc gcgtgcggcc agcaccgcaa gcacgtcgtc cagtacggca
     7081 gagcccacag gtgtccggtc ggctacgacg accttgtggt cgtccacgtc gagccgccct
     7141 gccaaggcca gttcaaggag gacagctcca gcggcggcgc aatctgtccg ccacggctcc
     7201 ggaaagcgcc cccgagcgtc aatggagagc agaaccacct gctcatcgag cgtcatttgc
     7261 atacccacaa cactcccaca cggctggcgg cctaatggag gcccgatgct gccgcatgcg
     7321 aggcagcaag atgacaccga aaccccttcg ttcggagatt gacgcatgcc atcgtatgtg
     7381 atgtcggaag cgagcagtcg aggaatccaa tcaccattct gatggcggga ttccgtgatt
     7441 tccgcgcact cggctcctga gtccggtgcc acacgagaaa ccacgaaagc acgagaaaga
     7501 aggagacacg ctcatgctgc ttgagaaggt caacaacagt cacctgctgg acaccgtact
     7561 gacggatgcc gcgaacgtgg aggacatgtc gccggccgag cccgtcctgt ccaccccggc
     7621 cgccgttgcc ggcggagccc tggtcaccgc gggtgcgttc ggagccggcg tcgggctcgg
     7681 ggtcacccag gcccaggccg gctgacaacc gccacatcgg cgccctaagc agaatcaaac
     7741 cgtcgctcaa ggagtaaacg tgactgcaat ctccaccaag gtcaacgcaa gccaggaact
     7801 caacggcgtc tcgatacacg ccggtgagaa cgagtggaac ggccggatgt ctccggtcct
     7861 cgccacccct gccgcggtcg gcgccgggct tgccggcgca gccgccatcg ccggtgcggc
     7921 agccggcggc attgcggtcg gaaacgccgc cgggcaggcc gcgggcggct gactcacgtc
     7981 gcaccaatgc cgcctctcga taaccacctg ccacccacgc cggtgagagg cggcacataa
     8041 ttcctatggc cggggaaggg aaagggaaga gcaaaaatga acatctcctc tgcggcacgg
     8101 agatcactct cctccccggt cataggccgg gagcgtgcac tgaccaccgc ggaacagctc
     8161 agcgcgaccg catatctcat gagcagcctg gaaatactgg cagccgaacg cgaccgccag
     8221 aaaggcggat tgaacaactg ggatctggcc cgggacaatt acacatgggc accgccgaag
     8281 gtgcgcgcgt cgctcgactt cctcgccagg ccggacgtca cccggtggat ccacggggcc
     8341 cgcgcacttg ccagcgcctc gctgctcgta ccgggcacca gtcggcgcca ccgcgctgcc
     8401 gcgaacggct tcctcgccct cacctcggtc gccacctacc cgaggcacca ctacggcacc
     8461 gacggatcgg atcagctctc cttcctcgtg cagtccgcgg ccatgatcgc ccgactcggc
     8521 cagcggcagc ccgcactcgt cgacagctgc ctgtggtacg tggcgctcca ggccacgctc
     8581 tcgtacgcca catcgggcta tgtgaagatc gccagcccca tctggcgctc cggcgaggcc
     8641 ctgccgggca tcatgcgcac cgagacctac ggtgacggca aggtctacga cctgatgaag
     8701 cgctatccca aggcatcccg gaagctggcg cacgcggtac tcgccatgga gtgcgccttc
     8761 cccgccgtat tcctcgccaa gggacggctc accccagcga tgctcgccgg actcggctcg
     8821 ttccacgtcg tcaatgcccg ggtgatgggt ctgagccgat tcgtgtgggc cttcctggcg
     8881 acctaccccg cgatcctcta cgtcacccag agccgcgagt ccacgaagcc cggcggaggc
     8941 agccgatgac cgcaaccacg aggatcacga tgcatcccgt gcgcaacgac gcgctccctc
     9001 gcatcgccgg cggcctgctg agcgccgtcg tcgcgaccgg gctgaccgtc cagcagcttc
     9061 gccaccgcag ggtgctgcgc ggccagggcg acgagtcgtt cttcgagacg tccacgggca
     9121 acgtgctcgc ctatcagctc accgaggccg aaggaccgga ttcgtcgccg gtcctggtct
     9181 gcgagaccgg cctgtgctcc accgtggagc actggatccg gctacgccgc atgctcggct
     9241 gcgaccaccc ggtcctggcg tacaaccggg ccgggtacgg acgaagtgag taccggctgc
     9301 gggagccctt ctcccttgcc gcggccgtcg ccgacctaag cgacctggtc cgtgcggtct
     9361 gcccctccag gccggtggta ctcgtcggac actcgctcgg cggccatctc acgctacggg
     9421 cgatcgagcc gctgcgcgac ctggtgaccg gcgttgtgct gctggacccc agccaccccg
     9481 ccgagctgct gcggtcgcgc gtgcaggccg acggcgccaa cgtgttgacc tccgctctgg
     9541 cgctcatgcc ggagtccgcc cggctcggtc tcggcagcct gctcacctct cctccctggc
     9601 tgcggtggct gcctgaggac atgcggccgc tgattctgga ccagttccgc gactggaagc
     9661 tgtggaaggc caccgttcgt gaatggcacg cgacccacac cgagttcctc gaccacgacg
     9721 gcgtgctgcc gaaggtcggc gtaccgctcc gcctggtggc cgcggccacc acgcacgcca
     9781 gggacccgat ccacgccgag ctgcaccggg aactcgttgg cacgtcgccc gatggcgacc
     9841 tgtgcctgat cgaggacgca aggcacgacg agctcgtgat gaacgaacgg cccgcggccc
     9901 aggtagcaga gctgatccgg gagttcacca tcggactccg cacgagcggg ctctgcacga
     9961 gcgggctccg cccgacactc gacgcgccgg aggtgcgctg atgttgctgc ccaggcccaa
    10021 gagcgaagcg ataaggcggg cggtggagct cggcttcgcg agctggctga cgatcacgat
    10081 actgagccag cacccgaaca cagccttcga tcggcttcgg acagccgaca aggtcgggct
    10141 gctcataccc aactggcggt tcttcgcccc gactccggcc cagcacgact accacttgct
    10201 gtaccggacg ctggataccg acggcgagca gtccgcctgg cagtcggcat cacagatcaa
    10261 caaacggaaa tgggcccacg ccgtctggtt tcccggacgc cgtcaggaga aggccatctt
    10321 cgacgtgtgc ggcgaactgg gccggttgat cgtccgtaag gatgtgaagg tcgccgacag
    10381 tgcggcgtac cggctgcttc gcgacttcgt catccggcac ctcgacgagt ccgacccgcg
    10441 acgcgtctcg ctcacgggct tccagttcct ggtggtgctc tacagcggac acgacgactc
    10501 cgaggacccg cagtactcct tcatctctcc cttcatccgg ctgtccgagc cagatcccac
    10561 ggaccacgcc ggcgacgccg atcacactgg tgccgcagat caattggagc acgcggcatg
    10621 acgaagagcg aggccgcgcc gcaggtcgac gaccccggct acggccgcag gttcgccgac
    10681 ttctacgaca agctcttccc caagaacgcc ggtgcggatg cgatagccga ggctctcgca
    10741 tccatggccg atggcggtcc cgccctggaa ctgggcgtgg gcaccgggcg gatcgccata
    10801 ccgctcgccg aacgcatcgg cgctgtcatc ggcgtcgact cctccccgga gatgctcgag
    10861 gaactgcgcc gcgacgtgga acgcgccgga gctccggtcc aggccgtcca cggtgacctg
    10921 cgcacatacg aggacgagtg cagctatccc ctcgtctacc tggtgtgcgg gaccctctcg
    10981 atggtgctcg agccccagca gcagcggcag gcggtcgcca gggccgcaca ccgcgtcgca
    11041 ccgggcggcc gcctggtgat cgagaacttc aacaccccgg gaatcctcgc catgagccag
    11101 gaaggcgggc acttcacctc cttcgctcct tacccggacc ccaacaccgg gctgctcacc
    11161 tcctggttgg tcgagaagga cacgggtctg tggcagtcgt cccacgtctg gttcgaggac
    11221 aacagcttcc gcatcgcctc cgacgtcaac cggctcatcc cgccggagga ggtcgaccgt
    11281 tacgcctccg cgtgcgggct ggaactggtt caccgctggt cggactggca gggcacggca
    11341 tacgacgagc gcggcgcgat gtacatcgcc gtctacgagg tcccctgacg ggatggtgag
    11401 acgggccggc gagcccggcg cggatcccag cagccaccga agcacgaccc accaactccg
    11461 ggacacgacc caccaactcc gggaggagcc cgcaatgacc gccacgcggt acaccgatcg
    11521 tcggcggggc cgcggacggc acagccgcaa gaccgaccgc actacctggg aggggacctg
    11581 cggcaagccg gattcagtct ggaccgtctc tctccagcac cgggcgctgc tgatcacggg
    11641 catgctgctg ggactactcg gtgtcgtcgc ctcgctcgcc cagccctacg ccatcggcaa
    11701 gctgatcgag actgccgagc tggaccagtc gctcgccggg ccgatcgctc tgctcgtcgt
    11761 actcttctgc gcggacgcgg ccttctcctc actccaggcc tacgccatcg gacgaaccgg
    11821 ggagaacatc gtcttcgacg tccgccggaa cctgatcgaa cggctggtgc gggccgaact
    11881 gacgtcggtg aacaagcagc cacagggcga catcctcacc cggacggtga ccgacacctc
    11941 cctcgtgaag atcgcacttt cgcagagcct ggcgcagctc ttcatcaacg gggcgacgat
    12001 catcggcggt gtcgccctga tgttcgccat cgacatctgg ctcatgctga tcacgctggc
    12061 ctgtctggga gtggccagcc tggtgtccat cggcctcgcc cgcaaactcc ggcaggtagc
    12121 cgtgcagaac cgtgaggaca ccggtgcgtt cggcaccgag gtgcagcggg tgctctcggc
    12181 gctgcccacg gtcaaggcct cccgtgcgga ggaccgggag ttgctgcgta tcggccaaca
    12241 ggcccacctc gcacgtacgt cgggaatccg ggtcaacgcg ttcaacgcgc tgctgatgcc
    12301 gtccatgaac gtcggtaccc aggcggcgct ggccatcgtg gtgggcgtcg ggatgacccg
    12361 cgtggccggc ggagcgatgt cgatcgccga cctgaccgcc tttgtgatgt acctcttcca
    12421 tctggtgtcg ccgctggtgc tgttcttcat ggccatcggc cagttcgtac aggggcgcgc
    12481 cgcggtacag cgggtggacg ggctggccgc actgccccag gaggggcagg aggaacgggt
    12541 ccagcagccc gccctcgtcg gatcgctgat ccaggaccgg ggcgcgatcg agttccacaa
    12601 cgtccggttc gggtatgacg ggcagagtgc ggacgcgaac gcgctggcgg gcgtgtcctt
    12661 ccacgtaccg acgcgcgggc tgaccgcgat cgtcggcccg tccggagcgg gcaagacgac
    12721 cctgttccag ctcatcgagc gcttctaccg gctggacggc ggcaggatcc ttctcggcgg
    12781 ccagaacatc gaagcactgc ccctggacac cgtccgcggg ctggtgggct acgtacagca
    12841 ggacagcgcg acgatgcgcg gcaccatccg ggagaacctc acctacgcca acccggaggc
    12901 cgcagaggcc gacatccgcg aggccgtgga gatggccggt ctctcggacg tcatccaagg
    12961 tctgccacaa ggactcgaca ccgatctggg cgatcagggc agcgggctct ccggcggtca
    13021 gcggcagcgg ctgtgcatcg cccgcacgct gctgcagaag cccgcgatca cacttctgga
    13081 cgaggccacc tctcatctgg actccgactc ggagcgggat ttccggcaag tgctccagcg
    13141 gatctcccgg cactgcgcgg tcgtcgcgat cgcgcaccgc atctccacgg tgatcgacgc
    13201 ggaccagatc gtcgtgctgg agaacggcag ggtccgtgcc accggagtcc acgacgatct
    13261 gatggagcgg gacgacctct accgccgtct cgccggctcc cagctccacg ccgagtcagg
    13321 gctcgtgggc gagccggtca ttccgcgact ggagcaacag cacccggcct acgaggcgtt
    13381 cgagtacccg ccgcagcaac tcaggccgga tgcggacgcg ttccagccgc agagcgcgga
    13441 gggcacctcg gacgtccagg ccggtcagca gttcccggaa ccggtgggcg gcaccatatg
    13501 acctccgccg acgtggcggt tgtgggtacc gggcccaatg ggttggcggc gggggtgact
    13561 ctggcccggg cgggcttgaa ggtggagctg tacgaggcgg ccgacaccat cggcggcgga
    13621 ctgcgcaccc agccgctctt cgagcaggac gtggcccacg acatctgcgc cgccgtccat
    13681 cccatggccg ccgcctcccg cttcttccgc gaattcgacc ttgccacccg cggcgtggaa
    13741 ctcctgcacc cggaaatctc ctacgcccac ccgctggaag gcggccgggc cggactcgcc
    13801 caccacgacc tggccgccac ctgcacggaa ctcggcccgg acggcgaacg ctggcggaca
    13861 ctgatgcagc cactgctgaa ccacagccag ggcgtggtgg acctgatcct ctccggccag
    13921 cgcaccctgc cccgcgaccc gtccgccgca ctggcactgg ccacccggat accggtacac
    13981 gccagccgtc tcggcgccgc ccgcttcgcc accgaagaag cagccgccct gctcaccggc
    14041 gtcgccgcac acgccatggg caaactcccc agcctcgcct ccgcagccgt cacgatgctg
    14101 ctgggtcacc tcgcccacgg aaccggctgg ccattgccac gcggcggcag cgcccgcatc
    14161 gcccgggcca tggccgccga catcaccgca cacggcggca gcttccacac caactgcccc
    14221 atcaccagcc tggaccagct cacgagcgcc cacacgatcc tgctggacac cagcgtcaaa
    14281 ggactactga ccctcgcaga ggaccaactg ccaccgcgct acacccgccg cctcaagcga
    14341 taccgctacg gcccagctgc cgccaaggtc gacttcctgg tcaccgaacc catcccctgg
    14401 gccaaccccg ccgtcgggag agccggaacc gtgcacctcg gcggcaccca cgcccagatg
    14461 atccaccagg agaccctgac cgcccgcggc atacccaccc aggaaccctt cgtgctgctg
    14521 gtcgacccag ccgtcaccga cccgggccgc gcccgccccg gcaaacgccc ggtatgggcc
    14581 tacgcccacg tccccaacgg cgactccaga gaacccgcag aactcgtgcg ctcccgcatc
    14641 gagcactacg cccccggctt caccgacacc atcctcgccc accgctgcgt caccggcgcc
    14701 ggctacgaga cctacaaccc caactacgtc ggcggcgaca tcggctgcgg cgccatgacc
    14761 ctgacccagt ccctcgcccg ccccaccctc agcatcgatc cctaccgcac cccactaccc
    14821 ggcctcttcc tgtgctccgc cgcaacccca ccaggaccca gcgtccacgg catgtccggc
    14881 tacctggccg cacaatccgc actgcgcaca cgcttcggca tcaccaccac accctcgctg
    14941 gcacccgagc cgactgtggc ggagggcatg ggctgacccg ggttcagatc cagccccgct
    15001 cgcgggccaa cagtgccgcc tgtgccctgt tgtcagcccc caggtgcttc atcacggctg
    15061 cgactttgcg ccggaacgta cgcaccgata cgccgatgct ccgtgcggcg gcctcgtcct
    15121 tgtcgcccga acacatggcc acgagcacct cccgcttggt cgcggcgctc agcgcttcgt
    15181 cggctgactc ctcgtctctg gccgggagtt cctcggcctg ttcccagatc cgccagaaga
    15241 gggcgacgat gctggagacc aacccgctct cgtgcgctat caacgctccg cgtgacgttt
    15301 ccacgggatc cacgggcacc acggcgacgt tccggtcgta ggccagaatg cgttccgtgg
    15361 tctcgtcgac gacccggatc cgtgctcctt ggcccgccag ttcgcgcaga taggcggctg
    15421 ttgggggatg atcgagcgcg gcgcgcagca cgatcatgtg cagccggatt cccctgcgca
    15481 gacagcgcag gtccaggcgg cgggcgtact cgatgctctc cggctgcaat tcctcgtagg
    15541 gttcgacgga gagcacttcc tcccgcgcga agaaggagag gtcgtctatc cggttgcgca
    15601 tctccgccag atccgtgagc tgctcgacat cacacgaggc ggtagtccgt gaactctgct
    15661 cggtacgcag cgaatcggcg atctgccgac acccggtgac ctgctggagt tcgctgtgca
    15721 gcgctcccag tcgctggtcc gcgagccgcg cgatggcggt gtgcggatcg gtagggatca
    15781 tgcggcaccc gccgatgatg cgcagcatgc ccaggtccag caacctgtca acacagtccg
    15841 gtactgactc cttgtcgagg ttcagctccg cgtggatctc ctcaacggag gtgttcgggt
    15901 tgcgtaggaa gtaccggtag accttttctt cggccgcgct cacaccgagc actgccatcg
    15961 cattggtatc caacccgcgc ccacgttgct cttgggtcgg ctggggctga cgacctgctc
    16021 tgatgcgcga cggacgacgc ggtggcgtgg gagcagggac gctgagaagc acatcacgca
    16081 tgggagttgg actcagagct cctcattcag gggcaggttc acgtggacag gccacaccgc
    16141 tcaccggtgt cggctgtacg tggactctct tggcagttgg taagcgaccc cggtggtctt
    16201 tgtggaaggc gcgctgctcg cactgctcgt gggcccgtgc gcccgtgcgt cgggtactgc
    16261 ccgacgcgac cagcccggtc gatatcgagg ttcacagaat ctgtggcagc gtttcaggtg
    16321 ggctgtcttc ggtaactgga ggtccgcccc cagtccggcg acgccgaacg ccttcgaccc
    16381 gcttgccgcg cttgtgtggc ctctgtgccg tggatctgaa tggtctggct catcgcagtc
    16441 atctctggga tctagagtca ttttcttcgg cccgaagtgt gtggactacg cgccaaagtg
    16501 atctgcccca tcacctgtct ttcgatcctc accggctgct gactgagtgt gcatcggcag
    16561 atcgtgcagc gatgaggggc ggtgcgaatc cgcacccgca cgacctggcc ggccgctacc
    16621 ggacgtcggg ggcgacaggg gccaccgggg gtgaccgcag gacgcccggg gcgtaccgat
    16681 ctggttcagc cgcatgacgg atagcacctc cacacaagcg aagaggaacg caagagatcg
    16741 gaatcaaaac cactcgactt ctcacacaga tcccgtcctg gttcttgtca cgcaagcacc
    16801 atgaactccg cccacttcgc ggccagatgc acgatgaggt ggtgagtcat gagcaggatg
    16861 cttccgcttc cctccgcact cttgtgcgca gcctggtgcg cctggaggca attgcgcgga
    16921 catctccgaa tggcgaaagc gggaaggatc aggcctcggt actggccgaa ctgcagagga
    16981 ccagtggctg ggccctgcga gccgctgtgg cacgtgcccg gcagcgggga gcgagctggc
    17041 gtcagctcgc cgtcacactc gacatgccgg cgatgacgct gcaccggcag ttcaactccg
    17101 gacacggcgt cttcgcgatc ggacagcacc gcggcggccc ggcgcccacg gagacgaaca
    17161 cggagacggg agaccgacag gcgaacgcgg ccggacagcc cacgttcgcc gacgccccgg
    17221 ccacctcccc aggagcgccg ccacgccagc aggacggcga tcccccggcc gtgctggacc
    17281 agctagtcgg gcgggaacgc gaactcgcgg acctgcgtcc gctactcgcc aagaaccgcc
    17341 tgatcaccct gaccggtccg ggtggcgtgg gcaagacgcg gctggcgctg gaatgcctcg
    17401 cgaagatccg cgcttcctac ggtggtggtg tgcggtgggt gaacctcgcg cccctgtcgg
    17461 atggctcgct ggtcgcgccc acggtcgcat cggccgtcct tggcggatcc atgccgaacg
    17521 gttccgtcga ggatgccgtc gcggacggct gcggctcccg gtccgccctc atcgtgctgg
    17581 acaactgcga gcatgtgatc gagagctgcg cggaactcgt cgaaccgtta ctggagcgat
    17641 gtccccggct cagtgtgctg gcgaccagcc gcgaagctct gcagatcacc ggtgagaccg
    17701 tcttccctgt cacacccctg cccgtacccg gatctggcag gggcaccgtg gcccgctccg
    17761 gcgccgccgt ccaactgttc gtacaccggg cgcgctcggt gcaaccatcc ttcaccctca
    17821 cggacacgat ggccgaaacc gtcgcgacgg tgtgcatgcg tctcgacggc atcccactcg
    17881 ccatcgaact ggccgcgcgg cagaccgcgt tcctctctcc cacccgtctg ctggaggacg
    17941 ccgaccggcg gctcgacctg ctggtgggag gtctgcgcac cgcgccgcac cgccaccaga
    18001 gcctgcggtc cgccatcagc tggagctacg acctgctcga cgcggagcag cagcaggtgt
    18061 tccgtcggat gtcagtgctc ccaggcggct tcgaggagcc attggcgacg gctctgtgcg
    18121 ccggtctcgg actgtccgga caccgtatgt ggacactgct gaccgccctg gccgacaagt
    18181 ccctgctggt gagcgaccag gtagccacgg gtcgattccg catgctcgag tcactgcggg
    18241 tcttcggccg ggaatgcctc gaagcggcag acgagtccga agaagtgcac gagcggctgc
    18301 tggcctggat ggcggatttc tcggagaggc tgttgctgtg gaccagcaac cccgccgtcg
    18361 acctcgccgg acaactcgat cgggaacgcc acaacctgca ctacgccgtc accaccgctg
    18421 aacgtctcgg cgatccgcga acaccgctcc tcggcgccgc gctcacgtcc tgctggaaca
    18481 ggcgcggcgt tccccgccag gccgagaggc tcgcggagag gctgctcgca gcccacgcgt
    18541 ccccttcggt aggacgtgcc tgcctgtcca ccacgctgtc ggacgcactc tgccgacgag
    18601 ggcaccacgc ggacgccgtc gcccccgcgg aggaagctct tggcatcgcc cagacccgag
    18661 agcatcccac gctcatcgtc cgcgcgctcg gtgcgctcag cagagtacgc agctgcctgg
    18721 gtgagcacga cgtggcgctt gagatatatc agcggcaggt ggagctgctc cgcacactgg
    18781 agcagcccac actcctcgcg atgatcctga accgcctcgc ctggaagctg ctgatgatcg
    18841 gccgggccga cgaggcgacc gggcacatcg aagaggcgct gtcgttactt gacagcgaca
    18901 acgcgctgga ggcgctcagc gccaccctgc acaccgcggc tggcgtctcc atcacccggc
    18961 agcggttcga agaggccgcc cagtacttca cgatggcgct caccatgcag tccgttgacg
    19021 ccgagggcaa gctgtacaac ctcgaaggcc tggcgctcgt cgccatgacc gacggccagc
    19081 ccgaacgcgg actgcgcctg ctctccaccg cgaaaacgat ccgggagaaa tcacatctgg
    19141 tcgctgacgc atggtggaac gacatggtgc agacggccgc ggagcgagcc cgccaggacc
    19201 tgcccccagc ccgtgccgcc gccgcgctgg cggacggggc ggagctcagc catgacgagg
    19261 tcatccgcta cgccctgcac aacgcctggc cgccgggccg ctgcgaccac cccgattcgg
    19321 ttctcacctc ccgccagtgg caggtggccg aactcgtcgc acagggcctg accaaccagc
    19381 agatcgccgc gcgtctgcac atctcgccac gtaccgccgc gagccatctg gaagccgtga
    19441 agatcagact gaatctgcag acccgagcac acgtggtcac ctgggtagcc gctaccgaac
    19501 acactcgcaa ggaatagcca ccacacaggc ggcgaagacc tcaccgacgc gctcggcacg
    19561 agaccgtcga gctgatcgtc cggctccgca gcagccgacg gaacagggcc tggacgccgg
    19621 ccccgacgcc ctcgtcccgg gcgtctcgcg agcgaagaag agcatgtcga tgaccatggc
    19681 ggtggtggcc ccggtccgca ccgcggccgg gggctgggcc cggcccctgt ggacgatgcc
    19741 gcgggcggct tggcgcagtg cgcggtcgtg gccgcggacg gcacggacgt gggttctgga
    19801 ggcacgctcg aacggccagg cggcttcgcg tagttcgcgt ccggtgtggg cggcggaggt
    19861 cgtggctagg gcgtcgagga cttcaccgcc ggcggcgatc cccgcggcga tggcgccgtc
    19921 gtcctgcagt ctctgatgct ggttcacgtg gcgcggttgg gggacgatgt ctcttcgccc
    19981 tgtaggaagt gagacggatg ctgagtctgg ccgactttct gtactcctcg gcggacagcc
    20041 tctgttacta cccggggatc catacattgc ggcgggaatc cgccgtggtc gagcgcgtgg
    20101 tgatcacgga tacggactgg cggctgagcg aggcggagcc gggcaaggcg gcgctggctg
    20161 tcatacctgc cgagggcgca gacatcgacg ccgccaccat cccgcaggcc atggcccgcc
    20221 tggtgcagca gggagtcacg gccatagctc tcacggcggc tgacggtgtg acattcccgg
    20281 acggcatcga gcgggaggcc gcccgctgcg gaatccccgt tcttgttcct gcgcgggcgg
    20341 ggagcgccac cgcggagcgt atccgcggtg acctggtgga cctccaggtg gccgtgcagg
    20401 aggcgcacag ggagcagatc gcgtacgggg cgcggctggc gacggagctg gagcatcgcg
    20461 acccggagaa tgccccggcc cgtctgaccc ggtggctggc aggcgaactg gcccgcgagg
    20521 aggccacggc acgacgggta ccgccgagcg agcggcctcc cgacatcatc accggcaacg
    20581 aggtcgccga ggaggcgtac cggcaggtgc gtgacgggaa g
//
